Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma.

Br J Haematol. 1998 Nov;103(2):308-10. Unique Identifier : AIDSLINE MED/99043599
Fujisao S; Tsuda H; Division of Clinical Haematology and Immunology, Kumamoto City; Hospital, Kumamoto, Japan.

Abstract: Peripheral T helper subsets in a patient with acquired pure red cell aplasia (PRCA) and thymoma were analysed by flow cytometry. Thymectomy resulted in a transient but definite improvement in anaemia. A continuous remission was attained by cyclosporin A (CsA) therapy. The changes in Th1/Th2 ratios corresponded with the haematological changes. Specifically, Th2 type lymphocytes were dominant during a haemopoietic suppression and elevation of the Th1/Th2 ratio was concomitant with haematological improvement. These observations suggest that polarization of Th subsets to Th2, induced by clonally expanded (gammadelta-type) T cells in thymoma, are involved in the pathogenesis of PRCA.
Keywords: JOURNAL ARTICLE Aged Case Report Female Human Paraneoplastic Syndromes/IMMUNOLOGY Red-Cell Aplasia, Pure/*IMMUNOLOGY Thymoma/*IMMUNOLOGY/THERAPY Thymus Neoplasms/*IMMUNOLOGY/THERAPY Th1 Cells/*PATHOLOGY Th2 Cells/*PATHOLOGYKWDjournalarticleagedcasereportfemalehumanparaneoplasticsyndromes/immunologyred-cellaplasia,pure/KWDimmunologythymoma/KWDimmunology/therapythymusneoplasms/KWDimmunology/therapyth1cells/KWDpathologyth2cells/KWDpathology
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A9931118

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