Summer-type hypersensitivity pneumonitis. T-cell receptor V gene usage in BALF T-cells from 3 cases in one family.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Summer-type hypersensitivity pneumonitis. T-cell receptor V gene usage in BALF T-cells from 3 cases in one family.

Sarcoidosis Vasc Diffuse Lung Dis. 1998 Sep;15(2):173-7. Unique Identifier : AIDSLINE MED/99006325
Shigematsu M; Nagai S; Nishimura K; Izumi T; Eklund AG; Grunewald J; Department of Pulmonary Medicine, Kyoto University, Japan.

Abstract: BACKGROUND AND AIM OF THE WORK: Hypersensitivity pneumonitis (HP) is a granulomatous lung disease characterized by a T lymphocyte bronchiolalveolitis and in several recent studies the preferential use of V beta regions of T-cell receptor (TCR) has been demonstrated. In Japan, summer-type HP, caused by Trichosporon cutaneum, is the most prevalent type of HP, and it is known by the familial occurrence. To clarify whether TCR expression could be restricted on lung T-cell and associate with the HLA type in an organic antigen-driven hyperimmune status, we examined three cases of summer-type HP in one Japanese family. METHODS: TCR expression on bronchoalveolar lavage (BAL) fluid T-cells was analyzed with 13 TCR V gene specific monoclonal antibodies. In addition, HLA types were analyzed using the microlymphocyte toxicity method. RESULTS: The changes in TCR expression were most frequently found in the BAL fluid CD8+ subset, but we found no preferential TCR V gene usage common to the three cases or correlation between the HLA type and the V gene usage. In two of the three cases who underwent a second lavage three months after the first one, some of the TCR expansions were preserved. CONCLUSION: Preferential usage of several TCR V genes was observed in three cases with summer-type HP in one family, but we could find neither a common T cell expansion nor any correlation between the HLA type and the TCR V gene usage.

Keywords: JOURNAL ARTICLE Adult Alveolitis, Extrinsic Allergic/*IMMUNOLOGY Biopsy Bronchoalveolar Lavage Fluid/CYTOLOGY Case Report CD4-CD8 Ratio CD4-Positive T-Lymphocytes/*IMMUNOLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY Follow-Up Studies Genes, T-Cell Receptor beta/*IMMUNOLOGY Histocompatibility Antigens Class I/IMMUNOLOGY Histocompatibility Antigens Class II/IMMUNOLOGY Histocompatibility Testing Human Male Receptors, Antigen, T-Cell, alpha-beta/IMMUNOLOGY Seasons
990330
A9931100

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