[The influence to the function of cellular immunity after being infected by HBV in the PBMC in chronic hepatitis B] NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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[The influence to the function of cellular immunity after being infected by HBV in the PBMC in chronic hepatitis B]

Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Apr;18(2):80-2. Unique Identifier : AIDSLINE MED/99029046
Xuan SY; Sun Y; Zhang J; Department of Infections Disease, Qingdao Municipal Hospital.

Abstract: In this study, HBV DNA was detected by PCR from PBMC of chronic hepatitis B. A total number of 54 cases were positive and 71 cases were negative. When detecting the competence of NK cells, the subgroup of T cells the ratio of CD4/CD8, the concentration of sIL-2R in three groups, and between the two CHB groups and a normal control group, the differences between HBV DNA positive group and HBV DNA negative group and between HBVDNA positive group and the normal control group were all dramatically significant (P < 0.01). We also found that a lineal correlation of the competence of NK cells, the ratio of CD4/CD8 and the concentration of sIL-2R(P < 0.01) in the positive group, whereas in the negative group only the ratio of CD4/CD8 was consistent with the concentration of sIL-2R(P < 0.01), and the competence of NK cells did not decrease obviously. The results indicated that it was the infection of HBV in PBMC which caused the disorder of the function of cellular immunity. This finding helped us to explain the pathogenesis of hepatitis B. It could also lay a theoretical ground for the prevention and the treatment of hepatitis B.
Keywords: JOURNAL ARTICLE Adolescence Adult CD4-CD8 Ratio DNA, Viral/ANALYSIS English Abstract Female Hepatitis B Virus/*ISOLATION & PURIF Hepatitis B, Chronic/*IMMUNOLOGY Human Immunity, Cellular/PHYSIOLOGY Killer Cells, Natural/*IMMUNOLOGY Leukocytes, Mononuclear/*VIROLOGY Male Middle Age Receptors, Interleukin-2/BLOODKWDjournalarticleadolescenceadultcd4-cd8ratiodna,viral/analysisenglishabstractfemalehepatitisbvirus/KWDisolation&purifhepatitisb,chronic/KWDimmunologyhumanimmunity,cellular/physiologykillercells,natural/KWDimmunologyleukocytes,mononuclear/KWDvirologymalemiddleagereceptors,interleukin-2/blood
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