Reciprocal regulation of Th1- and Th2-cytokine-producing T cells during clearance of parasitemia in Plasmodium falciparum malaria. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Reciprocal regulation of Th1- and Th2-cytokine-producing T cells during clearance of parasitemia in Plasmodium falciparum malaria.

Infect Immun. 1998 Dec;66(12):6040-4. Unique Identifier : AIDSLINE MED/99043944
Winkler S; Willheim M; Baier K; Schmid D; Aichelburg A; Graninger W; Kremsner PG; Department of Internal Medicine, Division of Infectious Diseases,; University of Vienna, Vienna, Austria.; stefan.winkler@akh-wien.ac.at

Abstract: Flow cytometry for the intracellular detection of T-cell cytokines was performed for 15 Gabonese patients during acute uncomplicated Plasmodium falciparum malaria. A striking expansion of CD4(+) and CD8(+) T cells producing gamma interferon (IFN-gamma) was found during drug-induced clearance of parasitemia, paralleled by a decrease of interleukin-2 (IL-2) production. The frequency of IL-4- and IL-13-producing CD4(+) cells gradually decreased, whereas the frequency of T cells producing IL-2(+)-IFN-gamma+, IL-4(-)-IL-5(+), and IL-4(+)-IL-5(+) cytokines as well as IL-4(+)-IFN-gamma+ and IL-13(+)-IFN-gamma+ cytokines was not significantly altered. The capacity for IL-10 production within the CD4(+) subset increased due to an expansion of both IL-10(+)-IFN-gamma- and IL-10(+)-IFN-gamma+ cytokine-expressing cells. Thus, a more pronounced Th2-driven immune response during acute untreated P. falciparum infection with a shift towards Th1 responsiveness induced by parasite clearance is suggested.
Keywords: JOURNAL ARTICLE Acute Disease Adolescence Adult Cells, Cultured Child Child, Preschool Cytokines/*BIOSYNTHESIS CD8-Positive T-Lymphocytes Female Flow Cytometry Gabon Human Lymphocyte Transformation Malaria, Falciparum/*IMMUNOLOGY Male Parasitemia/*IMMUNOLOGY Support, Non-U.S. Gov't Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGYKWDjournalarticleacutediseaseadolescenceadultcells,culturedchildchild,preschoolcytokines/KWDbiosynthesiscd8-positivet-lymphocytesfemaleflowcytometrygabonhumanlymphocytetransformationmalaria,falciparum/KWDimmunologymaleparasitemia/KWDimmunologysupport,non-uKWDsKWDgov'tth1cells/KWDimmunologyth2cells/KWDimmunology
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