Single amino acid change in DNA polymerase is associated with foscarnet resistance in a varicella-zoster virus strain recovered from a patient with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Single amino acid change in DNA polymerase is associated with foscarnet resistance in a varicella-zoster virus strain recovered from a patient with AIDS.

J Infect Dis. 1998 Nov;178 Suppl 1:S55-7. Unique Identifier : AIDSLINE MED/99070077
Visse B; Dumont B; Huraux JM; Fillet AM; Laboratoire de Virologie, CERVI, Hopital Pitie-Salpetriere,; Paris, France.

Abstract: The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at position 512 in the DNA polymerase, suggests that this mutation is implicated in the VZV foscarnet resistance. The other mutation, which replaces serine 863 by a glycine, is also present in 2 susceptible strains--Oka and a wild-type isolate.
Keywords: JOURNAL ARTICLE Adult Amino Acid Sequence Amino Acid Substitution Antiviral Agents/*PHARMACOLOGY AIDS-Related Opportunistic Infections/VIROLOGY Base Sequence Case Report Drug Resistance, Microbial/GENETICS DNA Primers/GENETICS DNA-Directed DNA Polymerase/*GENETICS Foscarnet/*PHARMACOLOGY Herpes Zoster/COMPLICATIONS/VIROLOGY Herpesvirus 3, Human/*DRUG EFFECTS/*ENZYMOLOGY/GENETICS Human Molecular Sequence Data Point Mutation Polymerase Chain Reaction Sequence Homology, Amino Acid Support, Non-U.S. Gov'tKWDjournalarticleadultaminoacidsequenceaminoacidsubstitutionantiviralagents/KWDpharmacologyaids-relatedopportunisticinfections/virologybasesequencecasereportdrugresistance,microbial/geneticsdnaprimers/geneticsdna-directeddnapolymerase/KWDgeneticsfoscarnet/KWDpharmacologyherpeszoster/complications/virologyherpesvirus3,human/KWDdrugeffects/KWDenzymology/geneticshumanmolecularsequencedatapointmutationpolymerasechainreactionsequencehomology,aminoacidsupport,non-uKWDsKWDgov't
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