A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.

Neurology. 1998 Dec;51(6):1682-8. Unique Identifier : AIDSLINE MED/99071165
Kieburtz K; Simpson D; Yiannoutsos C; Max MB; Hall CD; Ellis RJ; Marra CM; McKendall R; Singer E; Dal Pan GJ; Clifford DB; Tucker T; Cohen B; University of Rochester Medical Center, NY 14620, USA.

Abstract: BACKGROUND: Painful sensory neuropathy is a common complication of HIV infection. Based on prior uncontrolled observations, we hypothesized that amitriptyline or mexiletine would improve the pain symptoms. METHOD: A randomized, double-blind, 10-week trial of 145 patients assigned equally to amitriptyline, mexiletine, or matching placebo. The primary outcome measure was the change in pain intensity between baseline and the final visit. RESULTS: The improvement in amitriptyline group (0.31+/-0.31 units [mean+/-SD]) and mexiletine group (0.23+/-0.41) was not significantly different from placebo (0.20+/-0.30). Both interventions were generally well tolerated. CONCLUSIONS: Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy.
Keywords: CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL Adrenergic Uptake Inhibitors/*ADMINISTRATION & DOSAGE Adult Amitriptyline/*ADMINISTRATION & DOSAGE Anti-Arrhythmia Agents/*ADMINISTRATION & DOSAGE Double-Blind Method Drug Therapy, Combination Female Follow-Up Studies Human HIV Infections/*COMPLICATIONS Male Mexiletine/*ADMINISTRATION & DOSAGE Neuritis/COMPLICATIONS/VIROLOGY Pain/*DRUG THERAPY/VIROLOGY Peripheral Nerves/VIROLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.KWDclinicaltrialjournalarticlerandomizedcontrolledtrialadrenergicuptakeinhibitors/KWDadministration&dosageadultamitriptyline/KWDadministration&dosageanti-arrhythmiaagents/KWDadministration&dosagedouble-blindmethoddrugtherapy,combinationfemalefollow-upstudieshumanhivinfections/KWDcomplicationsmalemexiletine/KWDadministration&dosageneuritis/complications/virologypain/KWDdrugtherapy/virologyperipheralnerves/virologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
990330
A9931040

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