AIDS-associated nephropathy: 5-year retrospective morphologic analysis of 87 cases. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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AIDS-associated nephropathy: 5-year retrospective morphologic analysis of 87 cases.

Pathol Res Pract. 1998;194(8):567-70. Unique Identifier : AIDSLINE MED/98452527
Soriano-Rosas J; Avila-Casado MC; Carrera-Gonzalez E; Chavez-Mercado L; Cruz-Ortiz H; Rojo J; Department of Pathology, Mexico City General Hospital, National; University of Mexico, Mexico.

Abstract: Morphologic findings in the kidneys of 138 consecutive acquired immunodeficiency syndrome (AIDS) autopsies performed at the Mexico City General Hospital between 1986 and 1991 were studied. A total of 87 cases (63%) had renal disease, 62 cases presented glomerular alterations, and 80 cases showed tubulointerstitial damage. Glomerular collapse was seen in 30 cases (48%), mesangial expansion in 22 cases (35%), focal and segmental glomerulosclerosis in 20 cases (32%) and glomerular proliferation in only eight cases (11%). Nephrocalcinosis was seen in 25 cases (31%). Thirty-six cases (45%) presented tubulointerstitial infections: Mycobacterium tuberculosis in 19 cases (23%), Cryptococcus in 10 cases (12.5%), Cytomegalovirus CMV in eight cases (10%), Gram-negative bacteria in 3 cases (3.7%), and one case with histoplasmosis. In six cases the pathogens were multiple. Two cases showed infiltration of large-cell non-Hodgkin lymphoma. Based on the results obtained by autopsies, we conclude that in our country there is a high frequency of renal affection in AIDS patients. Clinically, this disease is infrequently diagnosed and not always related to the cause of death.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY Adolescence Adult Autopsy AIDS-Related Opportunistic Infections/*PATHOLOGY Child Child, Preschool Female Human Infant Kidney Diseases/*ETIOLOGY/*PATHOLOGY Male Middle Age Proteinuria/ETIOLOGY/PATHOLOGY Retrospective StudiesKWDjournalarticleacquiredimmunodeficiencysyndrome/KWDcomplications/pathologyadolescenceadultautopsyaids-relatedopportunisticinfections/KWDpathologychildchild,preschoolfemalehumaninfantkidneydiseases/KWDetiology/KWDpathologymalemiddleageproteinuria/etiology/pathologyretrospectivestudies
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