1999
- Perinatal listeriosis: a population-based multicenter study in Barcelona, Spain (1990-1996).
- Am J Perinatol. 1998 Aug;15(8):461-7. Unique Identifier : AIDSLINE MED/99002693
- Nolla-Salas J; Bosch J; Gasser I; Vinas L; de Simon M; Almela M; Latorre C; Coll P; Ferrer MD; Intensive Care Unit, Hospital del Mar, Autonomous University of; Barcelona, Spain.
- The aim off this study was to describe the incidence, epidemiology, clinical presentation, and outcome of perinatal listeriosis for a 7-year period (1990-1996) based on data of an active population-based surveillance project implemented in the city of Barcelona, Spain . There were 30
- Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity.
- Farmaco. 1998 Jul 30;53(7):455-61. Unique Identifier : AIDSLINE MED/99053177
- Sanna P; Carta A; Loriga M; Zanetti S; Sechi L; Istituto di Chimica Farmaceutica e Tossicologica, Sassari, Italy.
- A series of variously substituted quinoxalin-3-ones bearing an ethoxycarbonyl or carboxy group in the C-2 position has been prepared and their structures proved by 1H NMR spectroscopy. The obtained compounds were investigated in vitro for antimicrobial and anticancer activities. Preliminary results showed a moderate a
- Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives.
- Farmaco. 1998 Jul 30;53(7):462-7. Unique Identifier : AIDSLINE MED/99053178
- Dogan HN; Rollas S; Erdeniz H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Marmara; University, Istanbul, Turkey.
- In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, 1H NMR, a
- Evaluation of anti-HIV activity of 5-(2-phenyl-3'-indolal)-2-thiohydantoin.
- Farmaco. 1998 Jul 30;53(7):525-7. Unique Identifier : AIDSLINE MED/99053185
- Suzen S; Buyukbingol E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy; (ECZACILIK), Ankara University, Turkey.
- The anti-HIV activity of the previously synthesized 5-(2-phenyl-3 -indolal)-2-thiohydantoin I was evaluated. The compound, containing two structural moieties found in highly active anti-HIV agents, exhibited poor activity and rather high cytotoxicity.
- Quarterly Communicable Disease Review January to March 1998. From the PHLS Communicable Disease Surveillance Centre.
- J Public Health Med. 1998 Sep;20(3):359-64. Unique Identifier : AIDSLINE MED/99010318
- PHS recommendations for the management of health-care worker exposures to HIV--Part 2.
- Oncology (Huntingt). 1998 Oct;12(10):1447-9, 1453-4, 1457 passim. Unique Identifier : AIDSLINE MED/99014933
- Major surgery seems not to influence HIV disease progression in haemophilia patients.
- Br J Haematol. 1998 Oct;103(1):10-4. Unique Identifier : AIDSLINE MED/99006768
- Astermark J; Lofqvist T; Schulman S; Stigendal L; Lethagen S; Nilsson IM; Berntorp E; Department of Coagulation Disorders, University of Lund,; University Hospital, Malmo, Sweden.
- The influence of major surgery on HIV disease progression and decline in CD4+ cell count was evaluated in 23 seropositive haemophilia patients. 24 HIV-infected patients served as non-operated controls. In addition, 32 age-matched seronegative subjects were included. The follow-up time was up to 5 years. During the cou
- Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma.
- Br J Haematol. 1998 Oct;103(1):143-9. Unique Identifier : AIDSLINE MED/99006787
- Pastore C; Gaidano G; Ghia P; Fassone L; Cilia AM; Gloghini A; Capello D; Buonaiuto D; Gonella S; Roncella S; Carbone A; Saglio G; Dipartimento di Scienze Cliniche e Biologiche, Ospedale San; Luigi, Universita di Torino, Orbassano-Torino, Italy.
- The pathogenesis of AIDS-related non-Hodgkin s lymphomas (AIDS-NHL) involves accumulation of genetic lesions, stimulation and selection by antigen, as well as infection by viruses. Deregulation of cytokine loops has also been proposed to contribute to AIDS-NHL development, although data are available only for a limite
- B-cell chronic lymphocytic leukaemia with CD8 expression: report of 10 cases and immunochemical analysis of the CD8 antigen.
- Br J Haematol. 1998 Oct;103(1):157-62. Unique Identifier : AIDSLINE MED/99006789
- Mulligan SP; Dao LP; Francis SE; Thomas ME; Gibson J; Cole-Sinclair MF; Wolf M; Department of Haematology, Concord Hospital, Sydney, Australia.
- We report 10 cases of B-cell chronic lymphocytic leukaemia (B-CLL) with expression of the T-cell antigen CD8. The majority of patients had typical B-cell CLL with stable and non-progressive stage A(O) disease except for more common expression of lambda light chain and CD25. Two patients had progressive disease and req
- Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma.
- Br J Haematol. 1998 Nov;103(2):308-10. Unique Identifier : AIDSLINE MED/99043599
- Fujisao S; Tsuda H; Division of Clinical Haematology and Immunology, Kumamoto City; Hospital, Kumamoto, Japan.
- Peripheral T helper subsets in a patient with acquired pure red cell aplasia (PRCA) and thymoma were analysed by flow cytometry. Thymectomy resulted in a transient but definite improvement in anaemia. A continuous remission was attained by cyclosporin A (CsA) therapy. The changes in Th1/Th2 ratios corresponded with th
- IFN-gamma-secreting Th cells regulate both the frequency and avidity of epitope-specific CD8+ T lymphocytes induced by peptide immunization: an ex vivo analysis.
- Int Immunol. 1998 Sep;10(9):1273-9. Unique Identifier : AIDSLINE MED/99000392
- Romieu R; Baratin M; Kayibanda M; Guillet JG; Viguier M; INSERM U445, Institut Cochin de Genetique Moleculaire,; Universite Rene Descartes, Paris, France.
- CD8+ T lymphocytes are involved in protective immune responses to infected or tumor cells. In this report, we examined the regulation of antigen-specific CD8+ T cell frequency and avidity by distinct Th cell subsets. Peptide-specific CD8+ T cells were induced by immunization of mice with a MHC class I-restricted epito
- Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets.
- Int Immunol. 1998 Sep;10(9):1281-8. Unique Identifier : AIDSLINE MED/99000393
- Wack A; Cossarizza A; Heltai S; Barbieri D; D'Addato S; Fransceschi C; Dellabona P; Casorati G; Unita d'Immunochimica, DIBIT, Istituto Scientifico H. San; Raffaele, Milano, Italy.
- We have studied the effects of a life-long antigen stimulation on the clonal heterogeneity of human peripheral T cell subsets, as defined by their CD45 isoform expression. CD4+ or CD8+ T cells were obtained from healthy donors ranging in age from 20 to 100 years, and sorted into CD45RA+ and CD45RO+ populations. A modi
- Differential localization of Th1 and Th2 cells in autoimmune gastritis.
- Unique Identifier : AIDSLINE MED/99000398
- Katakai T; Mori KJ; Masuda T; Shimizu A
- The vast majority of CD4+ T cells infiltrating into gastric mucosa (GM) and in the draining (gastric) lymph node (GLN) shows an activated/memory phenotype, CD45RB(low) L-selectin(low) CD44(high), in neonataly thymectomized BALB/c mice bearing autoimmune gastritis (AIG), indicating that these cells are actively involve
- In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line.
- Int Immunol. 1998 Sep;10(9):1335-46. Unique Identifier : AIDSLINE MED/99000399
- Nelson AJ; Clegg CH; Farr AG; Department of Biological Structure, University of Washington,; Seattle, USA.
- Thymic epithelial cell lines isolated from hyperplastic thymi of transgenic mice over-expressing human papilloma viral oncogenes E6 and E7 constitutively displayed a phenotype consistent with a cortical origin. Exposure to IFN-gamma induced class II MHC and ICAM-1 expression, and up-regulated expression of VCAM-1 and
- The human immunodeficiency virus (HIV)-type 1 coreceptor CXCR-4 (fusin) is preferentially expressed on the more immature CD34+ hematopoietic stem cells.
- Ann Hematol. 1998 Nov;77(5):193-7. Unique Identifier : AIDSLINE MED/99073854
- Viardot A; Kronenwett R; Deichmann M; Haas R; Department of Internal Medicine V, University of Heidelberg,; Germany.
- In synergy with the CD4 antigen, the chemokine receptor CXCR-4 functions as a coreceptor for T-cell-tropic HIV-1 strains. Using two- and three-color immunofluorescence analysis, we examined the expression of CXCR-4 on CD34+ cells in 21 samples obtained from leukapheresis (LP) products of cancer patients who underwent
- Antiviral therapy in a child with pediatric human immunodeficiency virus (HIV): case study of audiologic findings.
- J Am Acad Audiol. 1998 Aug;9(4):292-8. Unique Identifier : AIDSLINE MED/98402075
- Christensen LA; Morehouse CR; Powell TW; Alchediak T; Silio M; Department of Communication Disorders, Louisiana State University; Medical Center, New Orleans 70112, USA.
- Over the past decade, much research has been conducted to determine the auditory consequences of human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). This research, primarily using adult patients, has focused on the involvement of the central auditory nervous system (CANS). Meas
- The ethics of placebo-controlled trials for perinatal transmission of HIV in developing countries [see comments]
- J Clin Ethics. 1998 Summer;9(2):156-66. Unique Identifier : AIDSLINE MED/98423561
- Clark PA; Department of Theology, St. Joseph's University, Philadelphia,; PA, USA.
- The "best proven therapeutic method" standard in clinical trials in technologically developing countries [see comments]
- J Clin Ethics. 1998 Summer;9(2):167-72. Unique Identifier : AIDSLINE MED/98423562
- Levine RJ; Yale University School of Medicine, New Haven, CT, USA.
- Deconstructing equity, autonomy, and ethical analysis [comment]
- J Clin Ethics. 1998 Summer;9(2):99-107. Unique Identifier : AIDSLINE MED/98423555
- Howe EG; Uniformed Services University of the Health Sciences, Bethesda,; MD, USA.
- HIV infection linked to substance use among hospitalized patients with severe mental illness.
- Psychiatr Serv. 1998 Oct;49(10):1269. Unique Identifier : AIDSLINE MED/98451173
- McKinnon K; Cournos F; Department of Psychiatry, Columbia University College of; Physicians and Surgeons and New York State Psychiatric Institute,; USA. kmm49@columbia.edu
- Endogenous retroviruses and multiple sclerosis. II. HERV-7q.
- C R Acad Sci III. 1998 Oct;321(10):857-63. Unique Identifier : AIDSLINE GENBANK/A60201
- Alliel PM; Perin JP; Pierig R; Nussbaum JL; Menard A; Rieger F; Inserm, Paris, France.
- The search for new endogenous retroviral sequences, on the basis of sequence homologies with the pol gene of the recently reported multiple sclerosis associated retrovirus (MSRV), allowed us to identify a full length endogenous retrovirus sequence located on the long arm of human chromosome 7. This retrovirus, HERV-7q
- The risk of serious odontogenic infections in HIV-positive patients: a pilot study.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Oct;86(4):406-9. Unique Identifier : AIDSLINE MED/99014956
- Miller EJ Jr; Dodson TB; Department of Oral/Maxillofacial Surgery, Boston, MA 02114, USA.; tdodson@partners.org
- OBJECTIVE: The purpose of this study was to perform a preliminary test of the hypothesis that patients infected with the human immunodeficiency virus (HIV) have an increased risk for serious odontogenic infections in comparison with HIV-negative patients. STUDY DESIGN: To address the research purpose, we used a case-c
- Reduced chlamydial infection and gonorrhea among commercial sex workers in Fukuoka City, Japan.
- Int J Urol. 1998 Sep;5(5):471-5. Unique Identifier : AIDSLINE MED/98452697
- Tanaka M; Nakayama H; Sakumoto M; Takahashi K; Nagafuji T; Akazawa K; Kumazawa J; Department of Urology, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.
- BACKGROUND: Until recently, epidemiologic studies of sexually transmitted diseases (STDs), including human immunodeficiency virus type-1 (HIV-1) infection, among Japanese female commercial sex workers and their patterns of condom use have been rare. We investigated trends in STDs among female commercial sex workers an
- Immunological analysis of rat renal transplant recipients exhibiting long-term survival following treatment with 15-deoxyspergualin in the early postoperative phase.
- Int J Urol. 1998 Sep;5(5):476-81. Unique Identifier : AIDSLINE MED/98452698
- Takeuchi I; Chikaraishi T; Seki T; Kanagawa K; Koyanagi T; Department of Urology, Hokkaido University School of Medicine,; Sapporo, Japan.
- BACKGROUND: We previously reported that short-term administration of 15-deoxyspergualin (DSG), 5 mg/kg/day on postoperative days 4 through 7, prolonged survival of rat renal allografts indefinitely. We now report the immunologic environment of DSG-treated recipients in the early postoperative phase. METHODS: TO (RT1u)
- Social network ties, self-efficacy, and condom use among women who use crack cocaine: a pilot study.
- Subst Use Misuse. 1998 Aug;33(10):2049-73. Unique Identifier : AIDSLINE MED/98416091
- Montoya ID; Affiliated Systems Corporation, Our Lady of the Lake University,; Houston, Texas 77027-6022, USA. ASC@Phoenix.Net
- So far, attempts to change the sexual risk behavior of women who use crack cocaine have been less successful than efforts to change the needle risk behavior of injection drug users. Two theoretical areas that have shown some success in predicting behavior change among of out-of-treatment drug users are Bandura s socia
- Performance of antenatal HIV screening strategies in the United Kingdom.
- J Med Screen. 1998;5(3):133-6. Unique Identifier : AIDSLINE MED/99011965
- Tookey PA; Gibb DM; Ades AE; Duong T; Masters J; Sherr L; Peckham CS; Hudson CN; Department of Epidemiology and Public Health, Institute of Child; Health, London, United Kingdom.
- BACKGROUND: In 1996 only 13.5% of previously undiagnosed HIV infected women were detected in pregnancy. In this study, all 265 maternity units in the United Kingdom were surveyed to determine the relation between screening strategy, uptake of testing, and detection rate. METHODS: Data
- Neomycin B inhibits splicing of the td intron indirectly by interfering with translation and enhances missplicing in vivo.
- RNA. 1998 Dec;4(12):1653-63. Unique Identifier : AIDSLINE MED/99063406
- Waldsich C; Semrad K; Schroeder R; Institute of Microbiology and Genetics, University of Vienna,; Austria.
- The aminoglycoside antibiotic neomycin B inhibits translation in prokaryotes and interferes with RNA-protein interactions in HIV both in vivo and in vitro. Hitherto, inhibition of ribozyme catalysis has only been observed in vitro. We therefore monitored the activity of neomycin B and several other aminoglycoside anti
- Summer-type hypersensitivity pneumonitis. T-cell receptor V gene usage in BALF T-cells from 3 cases in one family.
- Sarcoidosis Vasc Diffuse Lung Dis. 1998 Sep;15(2):173-7. Unique Identifier : AIDSLINE MED/99006325
- Shigematsu M; Nagai S; Nishimura K; Izumi T; Eklund AG; Grunewald J; Department of Pulmonary Medicine, Kyoto University, Japan.
- BACKGROUND AND AIM OF THE WORK: Hypersensitivity pneumonitis (HP) is a granulomatous lung disease characterized by a T lymphocyte bronchiolalveolitis and in several recent studies the preferential use of V beta regions of T-cell receptor (TCR) has been demonstrated. In Japan , summer
- A case of sarcoidosis with increased response of peripheral blood mononuclear cells to purified protein derivative antigen after depletion of CD8+ T-cells in vitro [letter]
- Sarcoidosis Vasc Diffuse Lung Dis. 1998 Sep;15(2):194-5. Unique Identifier : AIDSLINE MED/99006332
- Ishioka S; Hiyama K; Hozawa S; Maeda A; Maeda H; Yamakido M
- Reliability of the timeline follow-back sexual behavior interview.
- Ann Behav Med. 1998 Winter;20(1):25-30. Unique Identifier : AIDSLINE MED/98427923
- Weinhardt LS; Carey MP; Maisto SA; Carey KB; Cohen MM; Wickramasinghe SM; Department of Psychology, Syracuse University, NY 13244-2340,; USA.
- The reliability of self-reported sexual behavior is a question of utmost importance to human immunodeficiency virus (HIV) prevention research. The Timeline Follow-Back (TLFB) interview, which was developed to assess alcohol consumption on the event level, incorporates recall-enhancing techniques that result in reliabl
- Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: lack of association with Bcl-2 and p53 protein expression.
- Unique Identifier : AIDSLINE MED/99067325
- Kennedy MM; O'Leary JJ; Oates JL; Lucas SB
- HHV-8 is not associated with follicular dendritic cell tumours.
- Unique Identifier : AIDSLINE MED/99067328
- Nayler SJ; Taylor L; Cooper K
- Follicular dendritic cell tumours are rare malignancies derived from the follicular dendritic cells of lymphoid follicles. These tumours have been associated with Epstein-Barr virus infections and with the hyaline vascular subtype of Castleman s disease. Because many examples of Castleman s disease have been associate
- [Study of the reasons for spread of communicable diseases]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Apr;18(2):102-5. Unique Identifier : AIDSLINE MED/99029053
- Wei CY
- [Communicable disease control in China]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Apr;18(2):106-8. Unique Identifier : AIDSLINE MED/99029054
- Zeng G; Zhang JK; Zhang Y; Xu C; Rou KM; Cheng YK
- [Challenges for the prevention of communicable diseases (editorial)]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Apr;18(2):67-9. Unique Identifier : AIDSLINE MED/99029042
- Zeng G; Wei CY
- [The influence to the function of cellular immunity after being infected by HBV in the PBMC in chronic hepatitis B]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Apr;18(2):80-2. Unique Identifier : AIDSLINE MED/99029046
- Xuan SY; Sun Y; Zhang J; Department of Infections Disease, Qingdao Municipal Hospital.
- In this study, HBV DNA was detected by PCR from PBMC of chronic hepatitis B. A total number of 54 cases were positive and 71 cases were negative. When detecting the competence of NK cells, the subgroup of T cells the ratio of CD4/CD8, the concentration of sIL-2R in three groups, and between the two CHB groups and a no
- [A cohort study of HIV infection among intravenous drug users in Ruili and other two counties in Yunnan Province, China, 1992-1995]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Oct;18(5):259-62. Unique Identifier : AIDSLINE MED/99029027
- Zheng X; Zhang JP; Qu SQ; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing.
- Since 1992, cohort study of prevaience of HIV infection and incidence rate among drug users has been conducted annually at the study spots along southwestern border areas of Ruili, Longchuan and Luxi counties, Yunnan province of China . From 1992 to 1995, 859, 437, 343 and 540 drug u
- [New infectious diseases: occurrence and preventive strategies]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Oct;18(5):306-8. Unique Identifier : AIDSLINE MED/99029040
- Zhang XT
- [Molecular epidemiology of HIV infection]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Oct;18(5):309-11. Unique Identifier : AIDSLINE MED/99029041
- Yin TM
- Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.
- Unique Identifier : AIDSLINE MED/99059495
- Kinoshita S; Chen BK; Kaneshima H; Nolan GP; Department of Molecular Pharmacology, Stanford University School; of Medicine, California 94305, USA.
- Post HIV-1 entry, productive HIV-1 infection of primary T cells requires overcoming several cellular blocks to provirus establishment and replication. Activation of unknown host intracellular events overcomes such inhibitory steps and is concomitant with HIV-1 replication. We show that the transcription factor NFATc w
- Treatment of human immunodeficiency virus-positive patients with complementary and alternative medicine: a survey of practitioners.
- Unique Identifier : AIDSLINE MED/98435796
- Calabrese C; Wenner CA; Reeves C; Turet P; Standish LJ
- OBJECTIVE: To investigate complementary and alternative medicine (CAM) practices provided to human immunodeficiency virus (HIV)-infected individuals, provider experience in HIV disease,
- Expression of mouse mammary tumor virus-like env gene sequences in human breast cancer.
- Clin Cancer Res. 1998 Oct;4(10):2565-8. Unique Identifier : AIDSLINE MED/99011016
- Wang Y; Go V; Holland JF; Melana SM; Pogo BG; Department of Pathology, Mount Sinai School of Medicine, New; York, New York 10029, USA.
- We have reported previously (Wang et al, Cancer Res., 55: 5173-5179, 1995) the presence of a 660-bp sequence that is 90-98% homologous to the env gene of mouse mammary tumor virus in 38% of 314 unselected breast cancer samples, in some breast cancer cell lines, and in 1.8% of the 107 normal breast specimens from reduc
- Correspondence re: S. M. Melana et al., Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine. Clin. Cancer Res., 4: 693-696, 1998 [letter]
- Clin Cancer Res. 1998 Oct;4(10):2569-70. Unique Identifier : AIDSLINE MED/99011017
- Olivero OA; Gomez DE
- Non-Hodgkin's lymphoma risk derived from exposure to organic solvents: a review of epidemiologic studies.
- Cad Saude Publica. 1998;14 Suppl 3:41-66. Unique Identifier : AIDSLINE MED/99051486
- Rego MA; Centro de Estudos da Saude do Trabalhador--CESAT, Rua Pedro; Lessa 123, Canela, 40.110-050, Salvador, Bahia, Brasil.; mrego@lognet.com.br
- The rate of non-Hodgkin s lymphomas (NHL) has increased around the world during the last decades. Apart from the role of the human immunodeficiency virus (HIV) infection in the development of NHL, exposure to chemical agents like phenoxyacetic pesticides, hair dyes, metal fumes and organic solvents are suspected to be
- The role of neuroendocrine immune interactions in the initiation of humoral immunity in chickens.
- Domest Anim Endocrinol. 1998 Sep;15(5):409-22. Unique Identifier : AIDSLINE MED/99001224
- Mashaly MM; Trout JM; Hendricks G 3rd; al-Dokhi LM; Gehad A; Department of Poultry Science, Pennsylvania State University,; University Park 16802, USA.
- The presence of neuroendocrine immune interaction in mammalian species has been studied extensively and has been established. However, such an interaction is not as well established in avian species. Furthermore, the role of such an interaction in the initiation of humoral immunity is not well understood. Therefore, t
- Farmed deer: a large animal model for stress.
- Domest Anim Endocrinol. 1998 Sep;15(5):445-56. Unique Identifier : AIDSLINE MED/99001228
- Griffin JF; Thomson AJ; Department of Microbiology, University of Otago, Dunedin, New; Zealand.
- In the early classic period it was suggested by Heracleitus that a static unchanged state was not the natural condition, but rather that the capacity to undergo constant change was intrinsic to all living things. After that, Empedoeles, circa 500 BC, proposed that for living organisms to survive they require a harmoni
- [Polyneuropathies of pregnancy. Clinical neurophysiological, and anatomo-pathological study apropos of 38 cases collected at the Neurology Clinic of the the Fann University Hospital Center]
- Dakar Med. 1996;41(1):47-54. Unique Identifier : AIDSLINE MED/99044331
- Thiam A; Abd-Ali G; Ndiaye MM; Diagne M; Ndiaye IP; Clinique Neurologique de Fann, Dakar.
- Authors are studying the clinical, electrophysiological, and anatomical aspects of polyneuropathies of 28 observations in Clinic Neurologic of Fann, the onset occurred in pregnancy. Relations with Tropical Neuro-myelopathies (TNM) are emphasized. 28 observations concerning young women between 17 and 35 years old, the
- [Progressive noma: apropos of 27 cases seen at the National Hospital Center of Ouagadougou]
- Dakar Med. 1998;43(1):45-8. Unique Identifier : AIDSLINE MED/99044396
- Ouoba K; Sanou I; Dao M; Kam L; Ouedraogo A; Ouedraogo R; Sawadogo A; Service ORL, CHN Yalgado Ouedraogo, Ouagadougou, Burkina Faso.
- This retrospective study objects to report epidemiological profile, clinical display and take care of progressive noma at the National Hospital Center of Ouagadougou. We assign the term noma to the gangrenous gingivo-stomatitis occurring in a prone environment, leading in a few days into a sharp ulcer in the soft part
- [New HIV-1 variant discovered in Cameroon (news)]
- Dtsch Med Wochenschr. 1998 Nov 20;123(47):A7. Unique Identifier : AIDSLINE MED/99073340
- Kowalski A
- [HIV infection as an occupational disease in a hospital physician. Decision of the Federal Social Court 18 November 1997]
- Dtsch Med Wochenschr. 1998 Nov 27;123(48):1461. Unique Identifier : AIDSLINE MED/99076052
- Rieger HJ
- Rosai-Dorfman disease (extranodal sinus histiocytosis) in a patient with HIV.
- Ear Nose Throat J. 1998 Oct;77(10):855-8. Unique Identifier : AIDSLINE MED/99035944
- Perry BP; Gregg CM; Myers S; Lilly S; Mann KP; Prieto V; Division of Otolaryngology-Head and Neck Surgery, Duke University; Medical Center, Durham, North Carolina, USA.
- Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytosis of unknown etiology that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases, most often in the head and neck. Characteristic histologic findings include emperiopolese
- De novo status epilepticus as the presenting sign of neurosyphilis.
- Epilepsia. 1998 Dec;39(12):1367-9. Unique Identifier : AIDSLINE MED/99075419
- Primavera A; Solaro C; Cocito L; Department of Neurological Sciences, University of Genova, Italy.
- Although the incidence of seizures in neurosyphilis ranges from 14 to 60%, status epilepticus (SE) as a presenting complaint of neurosyphilis is definitely rare. A 44-year-old human immunodeficiency virus (HIV)-negative man with no history of epilepsy suddenly presented with acute mental confusion and was diagnosed ase
- Long-term effects of HIV counseling and testing for women: behavioral and psychological consequences are limited at 18 months posttest.
- Health Psychol. 1998 Sep;17(5):395-402. Unique Identifier : AIDSLINE MED/98446892
- Ickovics JR; Druley JA; Grigorenko EL; Morrill AC; Beren SE; Rodin J; Department of Epidemiology and Public Health, Yale University,; New Haven, Connecticut 06520-8034, USA.; jeannette.ickovics@yale.edu
- Behavioral and psychological consequences of HIV counseling and testing (HIV C&T) for women were examined in a longitudinal, prospective study. Women who received HIV C&T at community health clinics (n = 106) and a comparison group of never-tested women (n = 54) were interviewed five times over 18 months. There
- HIV sexual risk behavior following bereavement in gay men.
- Health Psychol. 1998 Sep;17(5):403-11. Unique Identifier : AIDSLINE MED/98446893
- Mayne TJ; Acree M; Chesney MA; Folkman S; Department of Psychology, New York University, New York; 10003-6634, USA. mayne@psych.nyu.edu
- The present study followed a group of 100 gay men up to 1 year before and 1 year after losing a partner to AIDS (University of California, San Francisco Coping Project). Following bereavement, participants were at increased risk for engaging in unprotected anal intercourse: at 4 to 6 months for HIV-negative men and at
- Number of pregnancies, outcome expectancies, and social norms among HIV-infected young women.
- Health Psychol. 1998 Sep;17(5):470-5. Unique Identifier : AIDSLINE MED/98446901
- Murphy DA; Mann T; O'Keefe Z; Rotheram-Borus MJ; Department of Psychiatry, Neuropsychiatric Institute, University; of California, Los Angeles, 90024, USA. dmurphy@mednet.ucla.edu
- In this descriptive study, researchers examined pregnancies, sexually transmitted diseases (STDs), and sexual behaviors among 67 HIV-infected young women, as well as the women s outcome expectancies and peer and partner norms regarding pregnancy. Many of the women (69%) had been pregnant; 42% had been pregnant at leas
- Lipophosphoglycan of Leishmania donovani inhibits lipid vesicle fusion induced by the N-terminal extremity of viral fusogenic simian immunodeficiency virus protein.
- Eur J Biochem. 1998 Nov 15;258(1):150-6. Unique Identifier : AIDSLINE MED/99067029
- Martin I; Turco SJ; Epand RM; Ruysschaert JM; Laboratoire de Chimie-Physique des Macromolecules aux Interfaces; (LCPMI) CP206/2, Universite Libre de Bruxelles, Brussels,; Belgium. imartin@ulb.ac.be
- Lipophosphoglycan (LPG), the major glycoconjugate of Leishmania parasites, was recently shown to be a potent inhibitor of viral infection. The mechanism by which this natural membrane amphiphile compound inhibits membrane fusion was investigated in this study using a simple model membrane system and a synthetic peptid
- Rapid analysis of epitope-paratope interactions between HIV-1 and a 17-amino-acid neutralizing microantibody by electrospray ionization mass spectrometry.
- Eur J Biochem. 1998 Nov 15;258(1):164-9. Unique Identifier : AIDSLINE MED/99067031
- Millar AL; Jackson NA; Dalton H; Jennings KR; Levi M; Wahren B; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry, UK.
- Progress in therapeutic or prophylactic immune intervention in HIV-1 infections may only come about with a detailed understanding at the molecular/atomic level of how antibodies neutralize (inactivate) virus infectivity. Currently information on the molecular aspects of antibody-virus interaction comes predominantly f
- Anthropometric indicators of human immunodeficiency virus infection in infants with early and late symptoms in the first months of life.
- Eur J Pediatr. 1998 Oct;157(10):811-3. Unique Identifier : AIDSLINE MED/99025691
- Agostoni C; Riva E; Gianni ML; Silano M; Giovannini M; Zuccotti GV; Department of Paediatrics, San Paolo Hospital, Milano, Italy.; agostoc@tin.it
- Standardised growth indices (Z-scores of weight-for-age, WA, length-for-age, LA, weight-for-length, WL, according to the reference data of the World Health Organization ) have been compared for the first 4 months of life among 119 infants born to mothers affected by the type-1 human imm
- Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1.
- Eur Respir J. 1998 Sep;12(3):619-26. Unique Identifier : AIDSLINE MED/98433754
- Bianco A; Sethi SK; Allen JT; Knight RA; Spiteri MA; Dept of Respiratory Medicine, North Staffordshire Hospital Trust,; UK.
- Intercellular adhesion molecule (ICAM)-1 is a cell receptor important in both human rhinovirus (HRV) attachment and immune effector cell mobilization. The level of expression of ICAM-1 by epithelial cells (EC) therefore plays a crucial role in the intricate biological phenomena underlying viral binding, host infection
- Infectious Th1 and Th2 autoimmunity in diabetes-prone mice.
- Immunol Rev. 1998 Aug;164:119-27. Unique Identifier : AIDSLINE MED/99011862
- Tian J; Olcott AP; Hanssen LR; Zekzer D; Middleton B; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles 90095-1735, USA.
- In the non-obese diabetic (NOD) mouse, a Th1-biased autoimmune response arises spontaneously against glutamic acid decarboxylase, concurrent with the onset of insulitis. Subsequently, Th1-type autoreactivity spreads intra- and intermolecularly to other beta-cell autoantigens (beta CAAs), suggesting that a spontaneous
- Immune focusing vs diversification and their connection to immune regulation.
- Immunol Rev. 1998 Aug;164:5-10. Unique Identifier : AIDSLINE MED/99011850
- Sercarz EE; Division of Immune Regulation, La Jolla Institute for Allergy &; Immunology, San Diego, CA 92121, USA. eli@liai.org
- Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51.
- Infect Immun. 1998 Dec;66(12):5684-91. Unique Identifier : AIDSLINE GENBANK/AF085217
- Vemulapalli R; Duncan AJ; Boyle SM; Sriranganathan N; Toth TE; Schurig GG; Center for Molecular Medicine and Infectious Diseases, Department; of Biomedical Sciences and Pathobiology, VA-MD Regional College; of Veterinary Medicine, Virginia Polytechnic Institute and State; University, Blacksburg, Virginia 24061-0342, USA.
- To identify Brucella antigens that are potentially involved in stimulating a protective cell-mediated immune response, a gene library of Brucella abortus 2308 was screened for the expression of antigens reacting with immunoglobulin G2a antibodies from BALB/c mice vaccinated with B. abortus RB51. One selected positive
- Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by the intravenous, subcutaneous, or intradermal route.
- Infect Immun. 1998 Dec;66(12):5743-50. Unique Identifier : AIDSLINE MED/99043899
- Power CA; Wei G; Bretscher PA; Department of Microbiology, University of Saskatchewan,; Saskatoon, Saskatchewan S7N 5E5 Canada.
- It is believed that cell-mediated immunity alone can contain Mycobacterium tuberculosis, the pathogen responsible for tuberculosis. The induction of antibody, or of a mixed cell-mediated/humoral response, is associated with tuberculous disease. It is therefore important to determine the conditions of immunization with
- Role of NK cells in early host response to chlamydial genital infection.
- Infect Immun. 1998 Dec;66(12):5867-75. Unique Identifier : AIDSLINE MED/99043917
- Tseng CT; Rank RG; Department of Microbiology and Immunology, University of Arkansas; for Medical Sciences, Little Rock, Arkansas 72205, USA.
- The cell-mediated immune response has been documented to be the major protective immune mechanism in mice infected genitally with the agent of mouse pneumonitis (MoPn), a biovar of Chlamydia trachomatis. Moreover, there is strong evidence to indicate that gamma interferon (IFN-gamma) is a major effector mechanism of t
- Specific-antibody-secreting cells in the rectums and genital tracts of nonhuman primates following vaccination.
- Infect Immun. 1998 Dec;66(12):5889-96. Unique Identifier : AIDSLINE MED/99043920
- Eriksson K; Quiding-Jarbrink M; Osek J; Moller A; Bjork S; Holmgren J; Czerkinsky C; Department of Medical Microbiology and Immunology, University of; G oteborg, Goteborg, Sweden. Kristina.Eriksson@microbio.gu.se
- To determine optimal strategies to induce specific-antibody-secreting cells (specific ASC) in the rectal and vaginal mucosae, we immunized monkeys with a prototype mucosal immunogen, cholera toxin (CT), given locally or via gastric or parenteral administration. Repeated rectal or vaginal CT immunizations induced stron
- Reciprocal regulation of Th1- and Th2-cytokine-producing T cells during clearance of parasitemia in Plasmodium falciparum malaria.
- Infect Immun. 1998 Dec;66(12):6040-4. Unique Identifier : AIDSLINE MED/99043944
- Winkler S; Willheim M; Baier K; Schmid D; Aichelburg A; Graninger W; Kremsner PG; Department of Internal Medicine, Division of Infectious Diseases,; University of Vienna, Vienna, Austria.; stefan.winkler@akh-wien.ac.at
- Flow cytometry for the intracellular detection of T-cell cytokines was performed for 15 Gabonese patients during acute uncomplicated Plasmodium falciparum malaria. A striking expansion of CD4(+) and CD8(+) T cells producing gamma interferon (IFN-gamma) was found during drug-induced clearance of parasitemia, paralleled
- Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells.
- Infect Immun. 1998 Dec;66(12):6058-62. Unique Identifier : AIDSLINE MED/99043948
- Miettinen M; Matikainen S; Vuopio-Varkila J; Pirhonen J; Varkila K; Kurimoto M; Julkunen I; Department of Virology, National Public Health Institute, 00300; Helsinki, Finland. minja.miettinen@ktl.fi
- Human peripheral blood mononuclear cells (PBMC) were stimulated with three nonpathogenic Lactobacillus strains and with one pathogenic Streptococcus pyogenes strain, and cytokine gene expression and protein production were analyzed. All bacteria strongly induced interleukin-1beta (IL-1beta), IL-6, and tumor necrosis f
- Drug monitoring during the treatment of AIDS-associated Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole.
- Unique Identifier : AIDSLINE MED/99000041
- Klinker H; Langmann P; Zilly M; Richter E
- OBJECTIVE: To monitor trimethoprim and sulfamethoxazole plasma levels in patients with AIDS-associated Pneumocystis carinii pneumonia. METHOD: Trimethoprim-sulfamethoxazole steady-state plasma concentrations were measured by high-pressure liquid chromatography during 37 episodes of Pneumocystis carinii pneumonia in pa
- Critical level and detection limit: performance measures for PCR-based assays.
- J Virol Methods. 1998 Oct;74(2):139-48. Unique Identifier : AIDSLINE MED/98450893
- Markert-Hahn C; Berding C; Kuhn C; Boehringer Mannheim GmbH, Department of New Technologies LP-DNS,; Penzberg, Germany.; christine_markert-hahn@bmg.boehringer-mannheim.com
- In clinical diagnostic work, sensitivity and specificity are key assay features. In this note we introduce two clinically relevant statistical assay performance measures, the critical level (CL), and the detection limit (DL) for the PCR-based assay. To allow for easy access to these characteristics a Windows-based pro
- Clinical evaluation and applications of the Amplicor HBV Monitor test, a quantitative HBV DNA PCR assay.
- Unique Identifier : AIDSLINE MED/98450895
- Gerken G; Gomes J; Lampertico P; Colombo M; Rothaar T; Trippler M; Colucci G
- Viral load has emerged recently as a reliable marker of disease progression and therapeutic efficacy in chronic infections, including AIDS and hepatitis C. The clinical management of type B hepatitis could also be improved by monitoring viremia levels in patients with chronic liver disease undergoing anti-viral treatm
- Female injecting drug users: human immunodeficiency virus risk behavior and intervention needs.
- J Prof Nurs. 1998 Nov-Dec;14(6):361-9. Unique Identifier : AIDSLINE MED/99056139
- Brown EJ; Center for Urban Health Research, School of Nursing, University; of Pennsylvania, Philadelphia 19104, USA.
- Injecting drug use and heterosexual contact are the major exposure categories for women acquiring human immunodeficiency virus (HIV). The purpose of this study was to explore the relationship of acquired immunodeficiency syndrome (AIDS) risk perception, perceived seriousness of HIV, drug use self-efficacy, sexual self
- Single amino acid change in DNA polymerase is associated with foscarnet resistance in a varicella-zoster virus strain recovered from a patient with AIDS.
- J Infect Dis. 1998 Nov;178 Suppl 1:S55-7. Unique Identifier : AIDSLINE MED/99070077
- Visse B; Dumont B; Huraux JM; Fillet AM; Laboratoire de Virologie, CERVI, Hopital Pitie-Salpetriere,; Paris, France.
- The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The
- Cytokine production in varicella-zoster virus-stimulated cultures of human blood lymphocytes.
- J Infect Dis. 1998 Nov;178 Suppl 1:S95-8. Unique Identifier : AIDSLINE MED/99070086
- Hayward AR; Cosyns M; Jones M; Levin MJ; Villanueba E; Weinberg A; Chan CY; Department of Pediatrics, University of Colorado School of; Medicine, Denver 80262, USA. anthony.hayward@uchsc.edu
- Estimates of responder cell frequency (RCF) based on limiting dilution analyses are laborious, and alternative means to quantitate cell-mediated immunity to immunogens are desirable. It was shown that levels of interleukin (IL)-2 in the supernatant of varicella-zoster virus-stimulated blood lymphocytes from immune adu
- [Etiology and therapy of secondary chronic glomerulonephritis]
- Nippon Naika Gakkai Zasshi. 1998 Jul 10;87(7):1277-86. Unique Identifier : AIDSLINE MED/98417797
- Sugisaki T
- Bragdon vs. Abbott [editorial]
- J Mich Dent Assoc. 1998 Sep;80(7):12. Unique Identifier : AIDSLINE MED/99080801
- Chase WR
- HAART and host: balancing the response to HIV-1. Highly active antiretroviral therapy [news]
- Lancet. 1998 Nov 21;352(9141):1686. Unique Identifier : AIDSLINE MED/99068342
- Morris K
- Ghost of AIDS musical returns to haunt South Africa's health minister [news]
- Lancet. 1998 Nov 21;352(9141):1688. Unique Identifier : AIDSLINE MED/99068344
- Baleta A
- Popular drama prompts interest in HIV in Japan [news]
- Lancet. 1998 Dec 5;352(9143):1840. Unique Identifier : AIDSLINE MED/99066724
- Watts J
- Treating HIV/AIDS information overload.
- Lancet. 1998 Dec 5;352(9143):1866. Unique Identifier : AIDSLINE MED/99066750
- Morris K; The Lancet, London, UK.
- Three new drugs for HIV infection.
- Med Lett Drugs Ther. 1998 Dec 4;40(1041):114-6. Unique Identifier : AIDSLINE MED/99071731
- Oral manifestations of HIV disease.
- Mt Sinai J Med. 1998 Oct-Nov;65(5-6):322-32. Unique Identifier : AIDSLINE MED/99060349
- Sirois DA; Department of Oral Pathology, Biology, and Diagnostic Sciences,; New Jersey Dental School, University of Medicine and Dentistry of; New Jersey, Newark 07103, USA.
- Oral disease is frequently associated with HIV. While nearly all oral disorders associated with HIV infection also occur in other conditions characterized by immunosuppression, no other condition is associated with as wide and significant a spectrum of oral disease as is HIV infection. Many HIV-associated oral disorde
- Transmission of infectious disease in the dental setting.
- Mt Sinai J Med. 1998 Oct-Nov;65(5-6):378-82. Unique Identifier : AIDSLINE MED/99060356
- Heir J; Ziccardi VB; Department of Oral and Maxillofacial Surgery, New Jersey Dental; School, University of Medicine and Dentistry of New Jersey,; Newark 07103-2400, USA.
- Patients in the industrialized world are at low risk of acquiring nosocomial infections; nevertheless, several aspects of care in the hospital or clinic can place patients at risk from infectious disease transmission. Paramount to the prevention of disease is the strict adherence to universal precautions for all patie
- Value of assessing cryptococcal antigen in bronchoalveolar lavage and sputum specimens from patients with AIDS.
- Mt Sinai J Med. 1998 Oct-Nov;65(5-6):422-5. Unique Identifier : AIDSLINE MED/99060364
- Bottone EJ; Sindone M; Caraballo V; Department of Medicine, Mount Sinai School of Medicine, New York,; NY 10029, USA.
- Cryptococcus neoformans has become a significant opportunistic pathogen, accounting for 8-10% of infectious complications in patients with AIDS. When encapsulated yeast cells are observed in Giemsa-stained smears of bronchoalveolar washings (BAL), or induced sputum specimens, confirmation as C. neoformans is germane t
- Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both. Community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group.
- N Engl J Med. 1998 Dec 24;339(26):1889-95. Unique Identifier : AIDSLINE MED/99067153
- El-Sadr WM; Murphy RL; Yurik TM; Luskin-Hawk R; Cheung TW; Balfour HH Jr; Eng R; Hooton TM; Kerkering TM; Schutz M; van der Horst C; Hafner R; Harlem Hospital Center and Columbia University College of; Physicians and Surgeons, New York, NY 10037, USA.
- BACKGROUND: Although trimethoprim-sulfamethoxazole is the drug of choice for the prevention of Pneumocystis carinii pneumonia, many patients cannot tolerate it and must switch to an alternative agent. METHODS: We conducted a multicenter, open-label, randomized trial comparing daily atovaquone (1500-mg suspension) with
- The care of HIV-infected adults in the United States. HIV Cost and Services Utilization Study Consortium [see comments]
- N Engl J Med. 1998 Dec 24;339(26):1897-904. Unique Identifier : AIDSLINE MED/99067155
- Bozzette SA; Berry SH; Duan N; Frankel MR; Leibowitz AA; Lefkowitz D; Emmons CA; Senterfitt JW; Berk ML; Morton SC; Shapiro MF; RAND Health, Santa Monica, CA, USA.
- BACKGROUND AND METHODS: In order to elucidate the medical care of patients with human immunodeficiency virus (HIV) infection in the United States , we randomly sampled HIV-infected adults receiving medical care in the contiguous United States at a facility other than military, prison, o
- Caring for people with human immunodeficiency virus infection [editorial; comment]
- N Engl J Med. 1998 Dec 24;339(26):1926-8. Unique Identifier : AIDSLINE MED/99067159
- Steinbrook R
- Screening for distal sensory peripheral neuropathy in HIV-infected persons in research and clinical settings.
- Neurology. 1998 Dec;51(6):1678-81. Unique Identifier : AIDSLINE MED/99071164
- Marra CM; Boutin P; Collier AC; Department of Neurology, University of Washington, Seattle, USA.
- OBJECTIVE: To determine the accuracy of a screening examination for distal sensory peripheral neuropathy (DSPN) performed by nonphysician clinicians and to explore the associations between DSPN and clinical features in HIV-infected persons. METHODS: A case-control stu
- A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
- Neurology. 1998 Dec;51(6):1682-8. Unique Identifier : AIDSLINE MED/99071165
- Kieburtz K; Simpson D; Yiannoutsos C; Max MB; Hall CD; Ellis RJ; Marra CM; McKendall R; Singer E; Dal Pan GJ; Clifford DB; Tucker T; Cohen B; University of Rochester Medical Center, NY 14620, USA.
- BACKGROUND: Painful sensory neuropathy is a common complication of HIV infection. Based on prior uncontrolled observations, we hypothesized that amitriptyline or mexiletine would improve the pain symptoms. METHOD: A randomized, double-blind, 10-week trial of 145 patients assigned equally to amitriptyline, mexiletine,
- AIDS-associated nephropathy: 5-year retrospective morphologic analysis of 87 cases.
- Pathol Res Pract. 1998;194(8):567-70. Unique Identifier : AIDSLINE MED/98452527
- Soriano-Rosas J; Avila-Casado MC; Carrera-Gonzalez E; Chavez-Mercado L; Cruz-Ortiz H; Rojo J; Department of Pathology, Mexico City General Hospital, National; University of Mexico, Mexico.
- Morphologic findings in the kidneys of 138 consecutive acquired immunodeficiency syndrome (AIDS) autopsies performed at the Mexico City General Hospital between 1986 and 1991 were studied. A total of 87 cases (63%) had renal disease, 62 cases presented glomerular alterations, and 80 cases showed tubulointerstitial dam
- [Nephrotoxicity of ritonavir]
- Presse Med. 1998 Nov 14;27(35):1801-3. Unique Identifier : AIDSLINE MED/99067686
- Deray G; Bochet M; Katlama C; Bricaire F; Service de Nephrologie, Groupe hospitalier Pitie-Salpetriere,; Paris.
- A RECOGNIZED COMPLICATION: Ritonavir is an antiprotease used in the treatment of HIV-positive patients. Among the known side effects, nephrotoxicity can be severe. We have observed acute renal failure in 8 patients. CIRCUMSTANCES: Renal failure occurs
- [Observing in HIV infections]
- Presse Med. 1998 Nov 14;27(35):1818-9. Unique Identifier : AIDSLINE MED/99067689
- Vittecocq D
- [Aspergillus fumigatus muscle abscess revealing invasive aspergillosis in a patient with AIDS (letter)]
- Presse Med. 1998 Nov 21;27(36):1844. Unique Identifier : AIDSLINE MED/99073362
- Vandenbos F; Roger PM; Mondain-Miton V; Burel F; Battaglione-Hofman V; Dellamonica P
- Transgenic cattle produced by reverse-transcribed gene transfer in oocytes.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14028-33. Unique Identifier : AIDSLINE MED/99045631
- Chan AW; Homan EJ; Ballou LU; Burns JC; Bremel RD; Endocrinology-Reproductive Physiology Program, University of; Wisconsin, 1675 Observatory Drive, Madison, WI 53706, USA.
- A critical requirement for integration of retroviruses, other than HIV and possibly related lentiviruses, is the breakdown of the nuclear envelope during mitosis. Nuclear envelope breakdown occurs during mitotic M-phase, the envelope reforming immediately after cell division, thereby permitting the translocation of th
- Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14045-50. Unique Identifier : AIDSLINE PDB/5TMP
- Lavie A; Ostermann N; Brundiers R; Goody RS; Reinstein J; Konrad M; Schlichting I; Department of Physical Biochemistry, Max Planck Institute for; Molecular Physiology, Rheinlanddamm 201, 44139 Dortmund, Germany.
- The crystal structures of Escherichia coli thymidylate kinase (TmpK) in complex with P1-(5 -adenosyl)-P5-(5 -thymidyl)pentaphosphate and P1-(5 -adenosyl)P5-[5 -(3 -azido-3 -deoxythymidine)] pentaphosphate have been solved to 2.0-A and 2.2-A resolution, respectively. The overall structure of the bacterial TmpK is very
- A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14088-93. Unique Identifier : AIDSLINE MED/99045642
- Zheng ZM; Huynen M; Baker CC; Basic Research Laboratory, Division of Basic Sciences, National; Cancer Institute, National Institutes of Health, Building 41,; Room D305, Bethesda, MD 20892-5055, USA. zheng@dce41.nci.nih.gov
- The bovine papillomavirus type 1 (BPV-1) exonic splicing suppressor (ESS) is juxtaposed immediately downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3 splice site at nucleotide 3225. The present study demonstrates that this pyrimidine-rich ESS inhibits utilization of upstream
- Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14314-9. Unique Identifier : AIDSLINE MED/99045681
- Tangri S; Brossay L; Burdin N; Lee DJ; Corr M; Kronenberg M; Division of Developmental Immunology, La Jolla Institute for; Allergy and Immunology, San Diego, CA 92121, USA.
- Mouse CD1(mCD1) molecules have been reported to present two types of antigens: peptides or proteins and the glycolipid alpha-galactosylceramide. Here, we demonstrate that a protein antigen, chicken ovalbumin (Ova), must be processed to generate peptides presented by mCD1 to CD8(+) T cells. The processing and mCD1-medi
- Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14349-54. Unique Identifier : AIDSLINE MED/99045687
- Levelt CN; Mizoguchi E; Huang X; Zacks R; Bhan AK; Tonegawa S; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge, MA 02139, USA. clevelt@wccf.mit.edu
- The mature T cell receptor (TCR) repertoire is shaped by positive- and negative-selection events taking place during T cell development. These events are regulated by interactions between the TCR and major histocompatibility complex molecules presenting self-peptides. It has been shown that many antagonist peptides ar
- HIV type-1 infection of the cotton rat (Sigmodon fulviventer and S. hispidus).
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14355-60. Unique Identifier : AIDSLINE MED/99045688
- Langley RJ; Prince GA; Ginsberg HS; Virion Systems, Inc., 9610 Medical Center Drive, Rockville, MD; 20850, USA.
- Cotton rats (Sigmodon hispidus and S. fulviventer) are susceptible to many viruses that infect humans (e.g., poliovirus, respiratory syncytial virus, influenza virus, adenovirus, and parainfluenza virus) and have been influential in developing therapeutic clinical intervention strategies for many viral infections of m
- The neutral glycosphingolipid globotriaosylceramide promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14435-40. Unique Identifier : AIDSLINE MED/99045702
- Puri A; Hug P; Jernigan K; Barchi J; Kim HY; Hamilton J; Wiels J; Murray GJ; Brady RO; Blumenthal R; Section of Membrane Structure and Function, Laboratory of; Experimental and Computational Biology, Division of Basic; Sciences, National Cancer Institute, National Institutes of; Health, Frederick, MD 21702, USA.
- Previously, we showed that the addition of human erythrocyte glycosphingolipids (GSLs) to nonhuman CD4(+) or GSL-depleted human CD4(+) cells rendered those cells susceptible to HIV-1 envelope glycoprotein-mediated cell fusion. Individual components in the GSL mixture were isolated by fractionation on a silica-gel colu
- Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14441-6. Unique Identifier : AIDSLINE +
- Nijhuis M; Boucher CA; Schipper P; Leitner T; Schuurman R; Albert J; Eijkman-Winkler Institute, Department of Virology, University; Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The; Netherlands.
- It has long been assumed that HIV-1 evolution is best described by deterministic evolutionary models because of the large population size. Recently, however, it was suggested that the effective population size (Ne) may be rather small, thereby allowing chance to influence evolution, a situation best described by a sto
- Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14500-5. Unique Identifier : AIDSLINE MED/99045713
- Meucci O; Fatatis A; Simen AA; Bushell TJ; Gray PW; Miller RJ; Department of Pharmacological and Physiological Sciences,; University of Chicago, 947 E. 58th Street (MC 0926), Chicago, IL; 60637, USA.
- The HIV-1 envelope protein gp120 induces apoptosis in hippocampal neurons. Because chemokine receptors act as cellular receptors for HIV-1, we examined rat hippocampal neurons for the presence of functional chemokine receptors. Fura-2-based Ca imaging showed that numerous chemokines, including SDF-1alpha, RANTES, and
- The olfactory loss that accompanies an HIV infection.
- Physiol Behav. 1998 Jun 15;64(4):549-56. Unique Identifier : AIDSLINE MED/98432375
- Hornung DE; Kurtz DB; Bradshaw CB; Seipel DM; Kent PF; Blair DC; Emko P; Smell and Taste Disorders Clinic, SUNY HSC, Syracuse, NY 13210,; USA. hornung@vm.stlawu.edu
- A number of studies have shown that HIV infection is associated with decreased olfactory ability. Additionally, it has been hypothesized that a reduced odorant identification may precede the advent of AIDS Dementia Complex (ADC). However, it is not known whether changes in olfactory ability are a manifestation of neur
- [Coping--status of knowledge in the 90's]
- Psychother Psychosom Med Psychol. 1998 Sep-Oct;48(9-10):321-37. Unique Identifier : AIDSLINE MED/99002142
- Heim E
- After a brief historical introduction the literature that has appeared on coping since the middle eighties is reviewed. Theoretically Lazarus concept of transactional coping has been developed with focus on emotions. Antonovsky s salutogenesis is considered to be innovative. Methodology is discussed in view of instru
- Tuberculosis among foreign-born residents of southern Florida, 1995.
- Public Health Rep. 1998 Nov-Dec;113(6):552-6. Unique Identifier : AIDSLINE MED/99064394
- Granich RM; Zuber PL; McMillan M; Cobb JD; Burr J; Sfakianaki ED; Fussell M; Binkin NJ; School of Public Health, UC Berkeley, CA 94720, USA. rhg6@cdc.gov
- OBJECTIVE: To examine the characteristics of foreign-born people with tuberculosis (TB) in Southern Florida, their contribution to the total number of TB cases, and available data on their HIV status as well as to determine the number of cases detected by the overseas medical screening of immigrants and refugees. METH
- [Pseudomonas aeruginosa as a pathogen in patients with human immunodeficiency virus infection]
- Rev Clin Esp. 1998 Sep;198 Suppl 2:37-43. Unique Identifier : AIDSLINE MED/99060467
- Vidal Marsal F; Mensa Pueyo J; Hospital Universitario de Tarragona Joan XXIII, Departamento de; Medicina y Cirugia, Universidad Rovira i Virgili.
- Transplacental transmission of hepatitis C virus in HIV-negative mothers.
- Res Virol. 1998 Jul-Aug;149(4):229-34. Unique Identifier : AIDSLINE MED/98456677
- Agha S; Sherif LS; Allam MA; Fawzy M; Clinical Pathology Department, Mansoura Faculty of Medicine,; Mansoura University, Egypt.
- The aim of this work was to evaluate transplacental transmission of hepatitis C virus (HCV) in HIV-negative pregnant women who were HCV-PCR-positive, and also to determine the serotypes of the virus in these cases. Therefore, 767 pregnant women were screened for anti-HCV antibodies, hepatitis B surface antigen (HBsAg)
- [Strategies for the use of anti-retroviral agents in HIV infection (1997). Extracts from the 4th Dormont Report]
- Rev Pneumol Clin. 1998 Feb;54(1):9-16. Unique Identifier : AIDSLINE MED/98442115
- [Lung diseases in HIV-infected children]
- Schweiz Med Wochenschr. 1998 Sep 12;128(37):1375-84. Unique Identifier : AIDSLINE MED/98456700
- Nadal D; Universitats-Kinderklinik Zurich.
- Pulmonary diseases, including opportunistic and bacterial infections, lymphoproliferative disorders, and neoplasia, substantially contribute to morbidity and mortality in HIV-infected children. Current treatment modalities are largely successful and thus justify invasive aetiological diagnostic procedures.
- On World AIDS Day, a shadow looms over southern Africa [news]
- Science. 1998 Dec 4;282(5395):1790-1. Unique Identifier : AIDSLINE MED/99084272
- Balter M
- Kick-starting the AIDS vaccine effort [news]
- Science. 1998 Dec 4;282(5395):1791. Unique Identifier : AIDSLINE MED/99084273
- Balter M
- AIDS research. New czar aims to sharpen France's effort [news]
- Science. 1998 Dec 4;282(5395):1799. Unique Identifier : AIDSLINE MED/99084277
- Balter M
- The enigmas of Kaposi's sarcoma.
- Science. 1998 Dec 4;282(5395):1837-9. Unique Identifier : AIDSLINE MED/99084284
- Gallo RC; Institute of Human Virology, University of Maryland, Baltimore,; MD 21201, USA. coleman@umbi.umd.edu
- Genetic acceleration of AIDS progression by a promoter variant of CCR5.
- Science. 1998 Dec 4;282(5395):1907-11. Unique Identifier : AIDSLINE MED/99055403
- Martin MP; Dean M; Smith MW; Winkler C; Gerrard B; Michael NL; Lee B; Doms RW; Margolick J; Buchbinder S; Goedert JJ; O'Brien TR; Hilgartner MW; Vlahov D; O'Brien SJ; Carrington M; Science Applications International Corporation (SAIC), National; Cancer Institute, Frederick MD 21702, USA.
- The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency virus-type 1 (HIV-1). Genetic association analysis of five cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infe
- Defective T cell differentiation in the absence of Jnk1.
- Science. 1998 Dec 11;282(5396):2092-5. Unique Identifier : AIDSLINE MED/99069629
- Dong C; Yang DD; Wysk M; Whitmarsh AJ; Davis RJ; Flavell RA; Section of Immunobiology, Howard Hughes Medical Institute, Yale; University School of Medicine, New Haven, CT 06520, USA.
- The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. JNK activity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice. T
- Psychological distress in blood donors notified of HTLV-I/II infection. Retrovirus Epidemiology Donor Study.
- Transfusion. 1998 Nov-Dec;38(11-12):1056-62. Unique Identifier : AIDSLINE MED/99056317
- Guiltinan AM; Murphy EL; Horton JA; Nass CC; McEntire RL; Watanabe K; Blood Centers of the Pacific, San Francisco, California.
- BACKGROUND: Blood donations in the United States have been screened for antibody to human T-cell lymphotropic virus types I and II (HTLV-I/II) since November 1988. Although clinically diagnosed illness associated with HTLV-I/II remains relatively uncommon, blood donors notified of HTLV
- Low prevalence of human T-cell lymphotropic virus type I infection among volunteer blood donors in Taiwan [letter]
- Transfusion. 1998 Nov-Dec;38(11-12):1118-9. Unique Identifier : AIDSLINE MED/99056325
- Chang CS; Wu YW; Pan YC; Chen ZY; Hsu A; Wang CS
- Effect of major histocompatibility complex expression on murine intestinal graft survival.
- Transplantation. 1998 Nov 27;66(10):1369-74. Unique Identifier : AIDSLINE MED/99060958
- Cagiannos C; Zhong R; Zang Z; Jiang J; Garcia BM; Chakrabarti S; Jevnikar AM; Sinclair NR; Grant DR; Department of Surgery, London Health Sciences Centre, Ontario,; Canada.
- BACKGROUND: Clinical intestinal transplantation has been plagued by frequent and severe graft rejection. It has been proposed that the major histocompatibility complex (MHC) antigens might play a critical role in this process owing to their extensive expression on enterocytes and mucosa-associated immune cells. METHOD
- Long-term nonprogressive human immunodeficiency virus-1 infection in a kidney allograft recipient.
- Transplantation. 1998 Nov 27;66(10):1384-6. Unique Identifier : AIDSLINE MED/99060960
- Purgus R; Tamalet C; Poignard P; Spire B; George F; Robert A; Olmer M; Department of Nephrology, Hopital Conception, Marseille, France.
- We report a unique case of a renal transplant patient with a long-term nonprogressive human immunodeficiency virus type-1 (HIV-1) infection and who is asymptomatic despite sustained immunosuppression. Renal function is normal, and HIV infection was probably acquired through blood transfusion before the transplant. Non
- CD8+ T lymphocytes account for acute accelerated allograft rejection in the rag mouse model.
- Transplant Proc. 1998 Nov;30(7):2952. Unique Identifier : AIDSLINE MED/99055680
- Yoshimura R; Wada S; Nakatani T; Tsujino T; Yamamoto K; Kishimoto T; Ohyama A; Chargui J; Touraine JL; Department of Urology, Osaka City University Hospital, Japan.
- Correlation between biopsies and noninvasive assessment of acute graft dysfunction.
- Transplant Proc. 1998 Nov;30(7):3069. Unique Identifier : AIDSLINE MED/99055731
- Akhtar F; Rana TA; Kazi J; Zafar N; Hashmi A; Bhatti S; Naqvi R; Mohsin R; Naqvi A; Rizvi A; Sindh Institute of Urology and Transplantation (SIUT), Dow; Medical College, Karachi, Pakistan.
- Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 and Epstein-Barr virus in immunosuppressed renal transplant recipients.
- Transplant Proc. 1998 Nov;30(7):3166-7. Unique Identifier : AIDSLINE MED/99055779
- Demirag A; Hizel N; Karakayali H; Moray G; Akkoc H; Bilgin N; Haberal M; Department of General Surgery, Faculty of Medicine, Baskent; University, Ankara, Turkey.
- Long-term results in human T-cell leukemia virus type 1-positive renal transplant recipients.
- Transplant Proc. 1998 Nov;30(7):3168-70. Unique Identifier : AIDSLINE MED/99055780
- Tanabe K; Kitani R; Takahashi K; Tokumoto T; Ishikawa N; Oshima T; Kanematsu A; Fuchinoue S; Yagisawa T; Ota K; Toma H; Department of Urology, Kidney Center, Tokyo Women's Medical; College, Japan.
- Differences in cellular mechanisms between heart and skin graft rejection by in vitro and in vivo analyses.
- Transplant Proc. 1998 Nov;30(7):3854. Unique Identifier : AIDSLINE MED/99056065
- Yamamoto T; Yamaguchi J; Gu W; Ishii T; Hashimoto T; Usui K; Mizoe A; Azuma T; Fujioka H; Furui J; Kanematsu T; Department of Surgery II, Nagasaki University School of Medicine,; Japan.
- Second-set rejection of skin allografts mediated by a T-cell subset in a chimeric mouse model.
- Transplant Proc. 1998 Nov;30(7):3858-9. Unique Identifier : AIDSLINE MED/99056067
- Yoshimura R; Wada S; Nakatani T; Tsujino T; Yamamoto K; Kishimoto T; Ohyama A; Chargui J; Touraine JL; Department of Urology, Osaka City University Hospital, Japan.
- Anti-alpha beta-T cell receptor monoclonal antibody induces tolerance without dominant infiltration by Th2 cells into grafts.
- Transplant Proc. 1998 Nov;30(7):3892. Unique Identifier : AIDSLINE MED/99056082
- Hamano K; Ito H; Shirasawa B; Bashuda H; Gohra H; Katoh T; Fujimura Y; Esato K; First Department of Surgery, Yamaguchi University School of; Medicine, Japan.
- The Warthin-Finkeldey-type giant cell in HIV infection, what is it?
- Ultrastruct Pathol. 1998 Jul-Aug;22(4):293-303. Unique Identifier : AIDSLINE MED/99022170
- Orenstein JM; Department of Pathology, George Washington University,; Washington, DC, USA. patjmo@gwumc.edu
- A study was conducted to ascertain the origin of the Warthin-Finkeldey-type giant cell that is common to lymphoid tissues of HIV-infected individuals. Light microscopy (LM) and transmission electron microscopy (TEM), in situ hybridization (ISH) (HIV-specific RNA), and immunohistochemistry (HIV p24, OPD4, CD3, CD45 UCH
- HIV infection and signal transduction.
- J Biol Regul Homeost Agents. 1998 Jul-Sep;12(3):63-6. Unique Identifier : AIDSLINE MED/99011925
- Bovolenta C; Camorali L; Lorini AL; Poli G; AIDS Immunophatogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milano, Italy. bovolenta.chiara@hsr.it
- Patient acceptance and shortened cycles paint optimistic future for therapeutic vaccine manufacturers [news]
- Allergol Immunopathol (Madr). 1998 Jul-Aug;26(4):201. Unique Identifier : AIDSLINE MED/99033198
- Detecting disseminated Mycobacterium avium complex infections in HIV-positive patients. The usefulness of bone marrow trephine biopsy specimens, aspirate cultures, and blood cultures.
- Am J Clin Pathol. 1998 Dec;110(6):806-9. Unique Identifier : AIDSLINE MED/99060584
- Hussong J; Peterson LR; Warren JR; Peterson LC; Department of Pathology, Northwestern University Medical School,; Chicago, Illinois, USA.
- Disseminated Mycobacterium avium complex (MAC) infections are common in patients with acquired immunodeficiency syndrome (AIDS). These patients frequently seek care with fever accompanied by generalized systemic symptoms and undergo bone marrow biopsy. It is our practice to stain all bone marrow trephine biopsy specim
- Correlates of HIV seropositivity and HIV testing among out-of-treatment drug users.
- Am J Drug Alcohol Abuse. 1998 Aug;24(3):377-93. Unique Identifier : AIDSLINE MED/98412972
- Collier K; Kotranski L; Semaan S; Lauby J; Halbert J; Feighan K; Philadelphia Health Management Corporation, Pennsylvania, USA.
- This study: 1) examined the rate and correlates of human immunodeficiency virus (HIV) seropositivity; and 2) assessed whether self-selection in HIV testing influenced the rate and correlates of HIV seropositivity in a group of out-of-treatment drug users. Data were collected from 856 out-of-treatment drug users in Phi
- Drug abuse treatment and risky sex: evidence for a cumulative treatment effect?
- Am J Drug Alcohol Abuse. 1998 Aug;24(3):439-51. Unique Identifier : AIDSLINE MED/98412976
- Longshore D; Hsieh S; UCLA Drug Abuse Research Center, Los Angeles, California 90024,; USA.
- This paper presents evidence regarding the possibility of a cumulative effect of drug-abuse treatment on reducing risky sexual behavior among individuals entering drug-abuse treatment in the United States from 1991-1993 and participating in the Drug Abuse Treatment Outcome Study (DATOS
- Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy.
- Am J Ophthalmol. 1998 Dec;126(6):817-22. Unique Identifier : AIDSLINE MED/99075349
- Jabs DA; Bolton SG; Dunn JP; Palestine AG; Department of Ophthalmology, The Johns Hopkins University School; of Medicine, Baltimore, Maryland, USA.; dajabs@welchlink.welch.jhu.edu
- PURPOSE: To describe our experience with discontinuation of anticytomegalovirus maintenance therapy in patients who have had immune reconstitution after initiation of highly active antiretroviral therapy. METHODS: Fifteen patients with treated cytomegalovirus retinitis, who had immune reconstitution after initiation o
- Epibulbar allergic granulomatous nodules in a human immunodeficiency virus-positive patient.
- Am J Ophthalmol. 1998 Dec;126(6):844-6. Unique Identifier : AIDSLINE MED/99075361
- Godfrey DG; Carr JD; Grossniklaus HE; Department of Ophthalmology, Emory University School of Medicine,; Atlanta, Georgia, USA.
- PURPOSE: To report an unusual epibulbar inflammatory process in a patient with human immunodeficiency virus (HIV). METHODS: Case report. A 32-year-old man developed fleshy epibulbar nodules on his right conjunctiva and cornea after being treated for conjunctivitis. A biopsy of the lesions was done, and the specimen wa
- T-cell-rich large-B-cell lymphomas contain non-activated CD8+ cytolytic T cells, show increased tumor cell apoptosis, and have lower Bcl-2 expression than diffuse large-B-cell lymphomas.
- Am J Pathol. 1998 Dec;153(6):1707-15. Unique Identifier : AIDSLINE MED/99061418
- Felgar RE; Steward KR; Cousar JB; Macon WR; Department of Pathology, Vanderbilt University Medical Center,; Nashville, Tennessee, USA. raymond.felgar@gte.net
- The factor(s) responsible for the reduced B cell number and increased T cell infiltrate in T-cell-rich large-B-cell lymphomas (TCRBCLs) have not been well characterized. We studied 18 TCRBCLs and 12 diffuse large-B-cell lymphomas (DLBCLs) to compare the 1) predominant T cell subpopulation(s), 2) expression of cytotoxi
- T cell apoptosis in human heart allografts: association with lack of co-stimulation?
- Am J Pathol. 1998 Dec;153(6):1813-24. Unique Identifier : AIDSLINE MED/99061429
- Van Hoffen E; Van Wichen DF; Leemans JC; Broekhuizen RA; Bruggink AH; De Boer M; De Jonge N; Kirkels H; Slootweg PJ; Gmelig-Meyling FH; De Weger RA; Department of Pathology, University Hospital, Utrecht, The; Netherlands.
- It is unclear whether the intracardial immune reactivity after heart transplantation influences the peripheral immunological status (activation or nonresponsiveness) of the patient. Co-stimulation and activation-induced cell death (AICD) or apoptosis play an important role in determining the balance between lymphocyte
- Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and hepatitis C virus: a case report and review of the literature.
- Am J Surg Pathol. 1998 Dec;22(12):1528-37. Unique Identifier : AIDSLINE MED/99065431
- Ichinohasama R; Miura I; Kobayashi N; Saitoh Y; DeCoteau JF; Saiki Y; Mori S; Kadin ME; Ooya K; Department of Oral Pathology, Tohoku University School of; Dentistry, Sendai, Japan. ryo@mail.cc.tohoku.ac.jp
- At present, there is no case report of HHV8- primary effusion lymphoma (PEL) with t(9;14)(p13;q32) involving both PAX-5 and immunoglobulin heavy chain gene rearrangement, which is a rare translocation in B-cell non-Hodgkin s lymphoma , in an HIV- patient. We examined an HIV-seronega
- In situ RT-PCR detection of Epstein-Barr virus immediate-early transcripts in CD4+ and CD8+ T lymphocytes.
- Anticancer Res. 1998 Sep-Oct;18(5A):3171-80. Unique Identifier : AIDSLINE MED/99075977
- Guan M; Romano G; Henderson EE; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, Pennsylvania 19140, USA.
- AIDS-related Epstein-Barr virus (EBV)-associated T cell lymphomas are emerging as a new, distinct histopathological entity. The pathway whereby EBV infects T cells as well as the initial EBV transcriptional program in T cells has not been established. In order to shed light on the early events of the EBV infection of
- Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107.
- Biochem Biophys Res Commun. 1998 Nov 18;252(2):524-8. Unique Identifier : AIDSLINE MED/99045440
- Shen B; Arese M; Gualandris A; Rifkin DB; Department of Cell Biology, Kaplan Cancer Center, and the Raymond; and Beverly Sackler Foundation Laboratory, New York University; Medical Center, New York, New York, 10016, USA.; shenb01@mcrcr6.med.nyu.edu
- By using the yeast two-hybrid system, we identified the ribosomal protein L6/TAXREB107 as an intracellular partner for FGF-2. L6/TAXREB107 also mediates the DNA binding of the HTLV-1 transactivator Tax. In vitro binding experiments indicated that both the high-molecular-weight forms (HMW) and the 18-kDa form of FGF-2
- Neurovirulent simian immunodeficiency virus induces calbindin-D-28K in astrocytes.
- Mol Chem Neuropathol. 1998 May;34(1):25-38. Unique Identifier : AIDSLINE MED/98451666
- Berman NE; Yong C; Raghavan R; Raymond LA; Joag SV; Narayan O; Cheney PD; Department of Anatomy and Cell Biology, University of Kansas; Medical Center, Kansas City 66160-7400, USA.
- Astrocyte activation has been postulated to be a major contributor to functional changes in the brain of AIDS patients. We assessed astrocyte activation in the simian immunodeficiency virus (SIV) model. Four groups of macaque brains were examined: uninoculated controls, animals inoculated with virus that did not cause
- Magnetoliposomes may be useful for elimination of HIV from infected individuals.
- Z Naturforsch [C]. 1998 Sep-Oct;53(9-10):935-6. Unique Identifier : AIDSLINE MED/99042988
- Babincova M; Machova E; Department of Biophysics and Chemical Physics, Comenius; University, Bratislava, Slovakia. babincova@fmph.uniba.sk
- A simple method is proposed for the treatment of the acquired immunodeficiency syndrome (AIDS) by introducing into the blood stream magnetoliposomes with coupled human immunodeficiency virus (HIV) receptor proteins. After some time lag, needed for binding of HIV and HIV-infected cells to magnetoliposomes, the arterio-
- [FDA approval of the first HIV anti-retroviral from DuPont-Pharma: SUSTIVA (efavirenz). SUSTIVA should be associated with other anti-retrovirals and could be considered a new alternative first line treatment]
- Allerg Immunol (Paris). 1998 Oct;30(8):268-70. Unique Identifier : AIDSLINE MED/99062627
- Increase in plasma viral load after oral cholera immunization of HIV-infected subjects.
- AIDS. 1998 Oct 1;12(14):F145-50. Unique Identifier : AIDSLINE MED/99006856
- Ortigao-de-Sampaio MB; Shattock RJ; Hayes P; Griffin GE; Linhares-de-Carvalho MI; Ponce de Leon A; Lewis DJ; Castello-Branco LR; Departamento de Imunologia, IOC, FIOCRUZ, Rio de Janeiro, Brazil.
- OBJECTIVE: Constant antigenic stimulation of the large immune cell population contained within gut-associated lymphoid tissue during HIV infection may contribute to patients total viral load. The aim of this investigation was to evaluate the effect of a mucosal antigenic challenge on HIV replication. DESIGN: Prospect
- A randomized double-blind trial of the addition of lamivudine or matching placebo to current nucleoside analogue reverse transcriptase inhibitor therapy in HIV-infected children: the PENTA-4 trial. Paediatric European Network for Treatment of AIDS.
- AIDS. 1998 Oct 1;12(14):F151-60. Unique Identifier : AIDSLINE MED/99006857
- OBJECTIVES: To evaluate the toxicity, tolerability and effect on laboratory markers of adding lamivudine ( 3TC ) to nucleoside analogue reverse transcriptase inhibitors (NRTI) in children with HIV-1 infection. DESIGN: Randomized double-blind trial. METH
- Stable rearrangements of the beta3-beta4 hairpin loop of HIV-1
- Unique Identifier : AIDSLINE MED/99006858
- Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway [editorial]
- AIDS. 1998 Oct 1;12(14):1735-44. Unique Identifier : AIDSLINE MED/99006859
- Brinkman K; ter Hofstede HJ; Burger DM; Smeitink JA; Koopmans PP; Department of General Internal Medicine, University Hospital; Nijmegen, The Netherlands.
- Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS.
- AIDS. 1998 Oct 1;12(14):1745-51. Unique Identifier : AIDSLINE MED/99006860
- Roos MT; Prins M; Koot M; de Wolf F; Bakker M; Coutinho RA; Miedema F; Schellekens PT; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Academic Medical; Centre, University of Amsterdam.
- OBJECTIVE: Decreased T-cell reactivity in vitro is strongly associated with progression to AIDS and low CD4+ T-cell numbers. Low T-cell responses in vitro induced by CD3 monoclonal antibody (mAb) are predictive for progression to AIDS independent of low CD4+ T-cell counts and high HIV-1 RNA levels. We developed a whol
- Purified Tat induces inflammatory response genes in Kaposi's sarcoma cells.
- AIDS. 1998 Oct 1;12(14):1753-61. Unique Identifier : AIDSLINE MED/99006861
- Kelly GD; Ensoli B; Gunthel CJ; Offermann MK; Winship Cancer Center, Department of Medicine, Emory University,; Atlanta, Georgia 30322, USA.
- OBJECTIVE: Kaposi s sarcoma (KS) is a neoplasm strongly associated with HIV-1 infection and marked by leukocytic infiltration. The infiltrating leukocytes are a possible source of inflammatory cytokines, human herpesvirus 8 (HHV8) and the HIV-1 transactivator protein Tat. This study examines whether Tat directly induc
- Persistent T cell and B cell activities in the duodenal mucosa of AIDS patients.
- AIDS. 1998 Oct 1;12(14):1763-9. Unique Identifier : AIDSLINE MED/99006862
- Carol M; Lambrechts A; Urbain D; van Vooren JP; Clumeck N; Goldman M; Mascart-Lemone F; Department of Immunology, Hopital Erasme, Bruxelles, Belgium.
- OBJECTIVE: As HIV infection most commonly occurs via a mucosal surface, and as gastrointestinal symptoms are very frequent among HIV-infected patients, we investigated the functional properties of residual lymphocytes in the duodenal mucosa from HIV-infected individuals. DESIGN: Duodenal biopsies and blood samples wer
- Persistence of Pseudomonas aeruginosa strains in respiratory infection in AIDS patients.
- AIDS. 1998 Oct 1;12(14):1771-5. Unique Identifier : AIDSLINE MED/99006863
- Asboe D; Gant V; Aucken HM; Moore DA; Umasankar S; Bingham JS; Kaufmann ME; Pitt TL; Department of Genitourinary/HIV Medicine, St Thomas' Hospital,; London, UK.
- OBJECTIVES: To establish the clinical pattern of Pseudomonas aeruginosa respiratory infections in HIV-seropositive patients and to determine whether repeated isolation of the organism represents reinfection or recurrence and to assess whether common source, nosocomial infection occurred. DESIGN AND METHODS: Evaluation
- Effect of indinavir on HIV-related wasting.
- AIDS. 1998 Oct 1;12(14):1777-84. Unique Identifier : AIDSLINE MED/99006864
- Carbonnel F; Maslo C; Beaugerie L; Carrat F; Wirbel E; Aussel C; Gobert JG; Girard PM; Gendre JP; Cosnes J; Rozenbaum W; Service de Gastroenterologie et de Nutrition, Hopital; Rothschild, Paris, France.
- OBJECTIVE: To study the effect of the protease inhibitor indinavir on body weight and body composition of subjects with HIV-related wasting. DESIGN: Prospective measurement of body weight in patients who had wasting and were treated with indinavir. A subgroup of 16 representative patients also underwent a metabolic st
- Serum immunoreactive erythropoietin levels and associated factors amongst HIV-infected children.
- AIDS. 1998 Oct 1;12(14):1785-91. Unique Identifier : AIDSLINE MED/99006865
- Allen UD; King SM; Gomez MP; Lapointe N; Forbes JC; Thorne A; Kirby MA; Bowker J; Raboud J; Singer J; Mukwaya G; Tobin J; Read SE; Canadian Pediatric AIDS Research Group.
- OBJECTIVES: To determine the spectrum of serum immunoreactive erythropoietin (SIE) levels amongst HIV-infected children aged
- Bacillary angiomatosis in immunocompromised patients.
- AIDS. 1998 Oct 1;12(14):1793-803. Unique Identifier : AIDSLINE MED/99006866
- Gasquet S; Maurin M; Brouqui P; Lepidi H; Raoult D; Unite des Rickettsies, CNRS UPRES A 6020, Universite de la; Mediterranee, Marseille, France.
- OBJECTIVES: To report seven cases of bacillary angiomatosis ; to evaluate the most useful diagnostic tools; to analyse the clinical and epidemiological features associated with Bartonella quintana or Bartonella henselae infections. DESIGN: Clinical, diagnostic and epidemiologi
- Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study.
- AIDS. 1998 Oct 1;12(14):1805-13. Unique Identifier : AIDSLINE MED/99006867
- Sperling RS; Shapiro DE; McSherry GD; Britto P; Cunningham BE; Culnane M; Coombs RW; Scott G; Van Dyke RB; Shearer WT; Jimenez E; Diaz C; Harrison DD; Delfraissy JF; Department of Obstetrics, Gynecology and Reproductive Science,; Mount Sinai School of Medicine, New York, New York, USA.
- OBJECTIVE: To determine the safety of the zidovudine (ZDV) regimen utilized in the Pediatric AIDS Clinical Trial Group (ACTG) 076 study. DESIGN: ACTG 076 was a randomized, double-blind, placebo-controlled trial which demonstrated that a ZDV regimen could prevent mother-to-child HIV-1 transmission. Infants were followe
- Opportunistic infections occurring during highly active antiretroviral treatment.
- AIDS. 1998 Oct 1;12(14):1815-22. Unique Identifier : AIDSLINE MED/99006868
- Michelet C; Arvieux C; Francois C; Besnier JM; Rogez JP; Breux JP; Souala F; Allavena C; Raffi F; Garre M; Cartier F; Infectious Disease Unit, Hopital Pontchaillou, University; hospital, Rennes, France.
- OBJECTIVE: To analyse the characteristics of opportunistic infections in patients receiving highly active antiretroviral treatment (HAART). DESIGN AND METHODS: A retrospective study performed in seven hospitals, included all patients starting treatment by
- CD4 cell count as a surrogate endpoint in HIV clinical trials: a meta-analysis of studies of the AIDS Clinical Trials Group.
- AIDS. 1998 Oct 1;12(14):1823-32. Unique Identifier : AIDSLINE MED/99006869
- Hughes MD; Daniels MJ; Fischl MA; Kim S; Schooley RT; Department of Biostatistics, and Center for Biostatistics in AIDS; Research, Harvard School of Public Health, Boston, Massachusetts; 02115, USA.
- OBJECTIVE: To evaluate initial changes in CD4 cell count as a surrogate endpoint for clinical outcome in HIV-infected patients. DESIGN: Meta-analysis of all relevant Phase II and III randomized clinical trials undertaken by the Adult AIDS Clinical Trials Group. METHODS: Individual patient data were obtained from each
- Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection.
- AIDS. 1998 Oct 1;12(14):1833-44. Unique Identifier : AIDSLINE MED/99006870
- Giorgi JV; Majchrowicz MA; Johnson TD; Hultin P; Matud J; Detels R; Multicenter AIDS Cohort Study and University of California Los; Angeles School of Medicine, 90095-1745, USA.
- OBJECTIVE: To evaluate the efficacy of combination protease and reverse transcriptase inhibitor therapy in correcting HIV-1-induced lymphocyte subset abnormalities in previously treated adults. DESIGN: A 48-week observational study of lymphocyte subsets in 12 participants in the Multicenter AIDS Cohort Study who were
- Involvement of hormonal circadian secretion in the growth of HIV-infected children.
- AIDS. 1998 Oct 1;12(14):1845-50. Unique Identifier : AIDSLINE MED/99006871
- Rondanelli M; Caselli D; Maccabruni A; Maghnie M; Bacchella L; DeStefano A; Solerte SB; Minoli L; Ferrari E; Department of Internal Medicine and Medical Therapy, IRCCS San; Matteo Hospital, Pavia, Italy.
- OBJECTIVE: To evaluate the circadian secretion of hormones involved in the regulation of growth in childhood, namely growth hormone, insulin-like growth factor (IGF)-I, cortisol, adrenocorticotropin hormone (ACTH), and thyroid-stimulating hormone (TSH) in HIV-infected children. DESIGN: The circadian secretory pattern
- Protection against sexually transmitted diseases by granting sex workers in Thailand the choice of using the male or female condom: results from a randomized controlled trial.
- AIDS. 1998 Oct 1;12(14):1851-9. Unique Identifier : AIDSLINE MED/99006872
- Fontanet AL; Saba J; Chandelying V; Sakondhavat C; Bhiraleus P; Rugpao S; Chongsomchai C; Kiriwat O; Tovanabutra S; Dally L; Lange JM; Rojanapithayakorn W; Joint United Nations Programme on HIV/AIDS (UNAIDS), Geneva,; Switzerland.
- BACKGROUND: The male condom is the most effective barrier method available for protection against sexually transmitted diseases (STDs), including HIV infection. There is an urgent need to develop and evaluate other prevention methods, such as the female condom. This study estimated the additional protection against ST
- The relationship of HIV prevalence in pregnant women to that in women of reproductive age: a validated method for adjustment.
- AIDS. 1998 Oct 1;12(14):1861-7. Unique Identifier : AIDSLINE MED/99006873
- Nicoll A; Stephenson J; Griffioen A; Cliffe S; Rogers P; Boisson E; HIV and STD Division, Public Health Laboratory Service; Communicable Disease Surveillance Centre, London, UK.
- OBJECTIVE: To devise and validate a method for adjusting HIV seroprevalences in pregnant women to estimate population prevalences among all women in their child-bearing years. DESIGN: Birth and termination rates from women with known HIV infection in the United Kingdom were calculated
- HIV testing and counseling among men attending sexually transmitted disease clinics in Pune, India: changes in condom use and sexual behavior over time.
- AIDS. 1998 Oct 1;12(14):1869-77. Unique Identifier : AIDSLINE MED/99006874
- Bentley ME; Spratt K; Shepherd ME; Gangakhedkar RR; Thilikavathi S; Bollinger RC; Mehendale SM; Department of International Health, School of Hygiene and Public; Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.
- OBJECTIVES: To describe changes in sexual behavior and condom use among male heterosexual clients at two public sexually transmitted disease (STD) clinics in Pune, after exposure to HIV testing, counseling, and condom promotion. DESIGN: From 13 May 1993 to 11 April 1997, 6819 heterosexual men were screened for HIV inf
- Migration, ethnicity and environment: HIV risk factors for women on the sugar cane plantations of the Dominican Republic.
- AIDS. 1998 Oct 1;12(14):1879-87. Unique Identifier : AIDSLINE MED/99006875
- Brewer TH; Hasbun J; Ryan CA; Hawes SE; Martinez S; Sanchez J; Butler de Lister M; Constanzo J; Lopez J; Holmes KK; AIDSCAP, Santo Domingo, Dominican Republic.
- OBJECTIVE: To determine risk factors for HIV infection among women living in the sugar cane plantation communities (bateyes) of a large private sugar cane company in the Dominican Republic . DESIGN: Cross-sectional study of sexually
- HIV-1 seroconversion in a prospective study of female sex workers in northern Thailand: continued high incidence among brothel-based women.
- AIDS. 1998 Oct 1;12(14):1889-98. Unique Identifier : AIDSLINE MED/99006876
- Kilmarx PH; Limpakarnjanarat K; Mastro TD; Saisorn S; Kaewkungwal J; Korattana S; Uthaivoravit W; Young NL; Weniger BG; St Louis ME; The HIV/AIDS Collaboration, Nonthaburi, Thailand.
- OBJECTIVES: To determine the incidence of HIV-1 infection, temporal trends in incidence, and risk factors for seroconversion in a cohort of female commercial sex workers (CSW) in upper northern Thailand , the region of Thailand with the highest rates of HIV-1 infection. METHODS: C
- Decline in sexually transmitted disease prevalence in female Bolivian sex workers: impact of an HIV prevention project.
- Unique Identifier : AIDSLINE MED/99006877
- Levine WC; Revollo R; Kaune V; Vega J; Tinajeros F; Garnica M; Estenssoro M; Lewis JS; Higueras G; Zurita R; Wright-De Aguero L; Pareja R; Miranda P
- HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in Kaliningrad.
- AIDS. 1998 Oct 1;12(14):1907-19. Unique Identifier : AIDSLINE MED/99006878
- Liitsola K; Tashkinova I; Laukkanen T; Korovina G; Smolskaja T; Momot O; Mashkilleyson N; Chaplinskas S; Brummer-Korvenkontio H; Vanhatalo J; Leinikki P; Salminen MO; Department of Infectious Disease Epidemiology, National Public; Health Institute, Helsinki, Finland.
- OBJECTIVES: To investigate the molecular epidemiology and genetic structure of the virus strain(s) causing an outbreak of HIV-1 infection in the Kaliningrad province of the Russian Federation and to investigate the relationship of this outbreak to some other emerging HIV-1 epidemics in the countries of the former Sovi
- Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985.
- AIDS. 1998 Oct 1;12(14):1921-5. Unique Identifier : AIDSLINE MED/99006879
- Olsen SJ; Chang Y; Moore PS; Biggar RJ; Melbye M; Division of Epidemiology, Columbia University, New York, New York; 10032, USA.
- BACKGROUND: Kaposi s sarcoma (KS)-associated herpesvirus (KSHV) is a newly discovered virus found in all forms of KS. In the United States , KSHV infection appears to be most common amongst individuals at high-risk for KS. Preliminary data from Africa suggest that KSHV infection may be
- HTLV-I infection in Spain. HTLV Spanish Study Group [letter]
- AIDS. 1998 Oct 1;12(14):1927-8. Unique Identifier : AIDSLINE MED/99006880
- Machuca A; Gutierrez M; Soriano V
- Molecular analysis of HIV-1 relatedness in a case of viral transmission during a bloody fight between two adults [letter]
- AIDS. 1998 Oct 1;12(14):1928-30. Unique Identifier : AIDSLINE GENBANK/AF023512
- Brambilla A; Salvatori F; Pristera R; Alfano M; Vicenzi E
- HIV suppression and risk of drug resistance mutations [letter]
- AIDS. 1998 Oct 1;12(14):1930. Unique Identifier : AIDSLINE MED/99006882
- Phillips AN; Loveday C; Johnson MA
- Transient foscarnet-induced hypercalcaemia [letter]
- AIDS. 1998 Oct 1;12(14):1930-1. Unique Identifier : AIDSLINE MED/99006883
- Barba R; Gomez-Rodrigo J; Marco J; Espejo M; Mena D
- Decline in the rate of specific opportunistic infections at San Francisco General Hospital, 1994-1997 [letter]
- AIDS. 1998 Oct 1;12(14):1931-3. Unique Identifier : AIDSLINE MED/99006884
- Holtzer CD; Jacobson MA; Hadley WK; Huang L; Stanley HD; Montanti R; Wong MK; Stansell JD
- Poverty and prognosis of HIV infection in Switzerland. Swiss HIV Cohort Study [letter]
- AIDS. 1998 Oct 1;12(14):1933-4. Unique Identifier : AIDSLINE MED/99006885
- Ledergerber B; Egger M; Rickenbach M; Weber R
- Delayed HIV-1 seroconversion after antiretroviral therapy [letter]
- AIDS. 1998 Oct 1;12(14):1935-6. Unique Identifier : AIDSLINE MED/99006886
- Apetrei C; Tamalet C; Edlinger C; Damond F; Descamps D; Saimot AG; Brun-Vezinet F; Simon F
- Acute non-lymphoblastic leukemia with an unusual chromosomal abnormality in a patient with advanced AIDS [letter]
- AIDS. 1998 Oct 1;12(14):1936-7. Unique Identifier : AIDSLINE MED/99006887
- Mangialardi WJ; Raffanti SP
- Disease progression and poor survival of AIDS-associated progressive multifocal leukoencephalopathy despite highly active antiretroviral therapy [letter]
- AIDS. 1998 Oct 1;12(14):1937-8. Unique Identifier : AIDSLINE MED/99006888
- De Luca A; Ammassari A; Cingolani A; Giancola ML; Antinori A
- Acute clinical hepatitis in an HIV-seropositive hepatitis B carrier receiving protease inhibitor therapy [letter]
- AIDS. 1998 Oct 1;12(14):1939-40. Unique Identifier : AIDSLINE MED/99006889
- Mastroianni CM; Trinchieri V; Santopadre P; Lichtner M; Forcina G; D'Agostino C; Corpolongo A; Vullo V
- Tribute to Jonathan Mann.
- AIDS. 1998 Oct 22;12(15):ii-v. Unique Identifier : AIDSLINE MED/99030022
- Ryder RW; Paul JR; Yale University School of Public Health, New Haven, Connecticut,; USA.
- Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients.
- AIDS. 1998 Oct 22;12(15):F167-73. Unique Identifier : AIDSLINE MED/99030023
- Walli R; Herfort O; Michl GM; Demant T; Jager H; Dieterle C; Bogner JR; Landgraf R; Goebel FD; Infektionsambulanz, Medizinische Poliklinik, Ludwig-Maximilians; Universitat Munchen, Germany.
- BACKGROUND: The use of protease inhibitors in the treatment of HIV-1 infection is associated with the new onset of diabetes mellitus, hyperlipidaemia and lipodystrophy. It is unclear whether these findings are coincidental or whether they reflect a causative effect
- Do viral load and CD8 cell count at initiation of tritherapy influence the increase of CD4 T-cell count?
- AIDS. 1998 Oct 22;12(15):F175-9. Unique Identifier : AIDSLINE MED/99030024
- Keita-Perse O; Roger PM; Pradier C; Pugliese P; Cottalorda J; Dellamonica P; Service des Maladies Infectieuses et Tropicales, Hopital; l'Archet 1, Nice, France.
- BACKGROUND: Tritherapies including protease inhibitors improve clinical status and usually increase CD4 T cell count. However, the dissociation between the marked decreases in viral load and the incomplete restoration of CD4 cell counts with a three-drug combination
- Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: implications for transmission.
- AIDS. 1998 Oct 22;12(15):F181-9. Unique Identifier : AIDSLINE +
- Eron JJ; Vernazza PL; Johnston DM; Seillier-Moiseiwitsch F; Alcorn TM; Fiscus SA; Cohen MS; Department of Medicine, University of North Carolina at Chapel; Hill, 27599-7030, USA.
- OBJECTIVES: To evaluate blood and genital secretions from HIV-infected men for HIV-1 resistant to antiretroviral agents. DESIGN: A longitudinal study of 11 men with HIV infection and persistent detectable HIV RNA levels in blood and semen on antiretroviral therapy. METHODS: HIV-1 from the blood and seminal plasma, obt
- Individual prognoses of long-term responses to antiretroviral treatment based on virological, immunological and pharmacological parameters measured during the first week under therapy.
- AIDS. 1998 Oct 22;12(15):F191-6. Unique Identifier : AIDSLINE MED/99030026
- Mueller BU; Zeichner SL; Kuznetsov VA; Heath-Chiozzi M; Pizzo PA; Dimitrov DS; HIV and AIDS Malignancy Branch, National Cancer Institute, NIH,; Bethesda, MD 20892, USA.
- OBJECTIVE: To predict long-term (12 weeks or longer) virological responses to antiretroviral treatment from measurements made during the first few days on therapy. METHODS: Forty-one HIV-1-infected children were treated with ritonavir for 12 weeks fol
- Antiretroviral drugs and the central nervous system [editorial]
- AIDS. 1998 Oct 22;12(15):1941-55. Unique Identifier : AIDSLINE MED/99030027
- Enting RH; Hoetelmans RM; Lange JM; Burger DM; Beijnen JH; Portegies P
- Recruitment of the TATA-binding protein to the HIV-1 promoter is a limiting step for Tat transactivation.
- AIDS. 1998 Oct 22;12(15):1957-64. Unique Identifier : AIDSLINE MED/99030028
- Majello B; Napolitano G; Lania L; Department of Genetics, Molecular and General Biology, University; of Naples Federico II, Italy.
- OBJECTIVES: To examine the functional interaction between HIV-1 Tat protein and the TATA-binding protein (TBP). DESIGN: HIV long terminal repeat reporter plasmids were cotransfected into mammalian and Drosophila insect cells with expression vectors encoding Tat and vectors encoding TBP either alone or linked to an het
- Effect of malabsorption on nutritional status and resting energy expenditure in HIV-infected patients.
- AIDS. 1998 Oct 22;12(15):1965-72. Unique Identifier : AIDSLINE MED/99030029
- Jimenez-Exposito MJ; Garcia-Lorda P; Alonso-Villaverde C; de Virgala CM; Sola R; Masana L; Arija V; Izquierdo V; Salas-Salvado J; Human Nutrition Unit, Faculty of Medicine and Health Sciences,; Rovira i Virgili University, Reus, Spain.
- OBJECTIVE: To assess the influence of malabsorption on nutritional status and energy expenditure in patients at different stages of HIV infection. DESIGN AND METHODS: Fifty HIV patients were classified into three groups: Group 1, HIV asymptomatic patients (n=17); Group 2, AIDS without opportunistic infection (n=16); G
- Coexisting members of HIV-1 p17 gene quasispecies represent proteins with distinct antigenicity and immunogenicity.
- AIDS. 1998 Oct 22;12(15):1973-81. Unique Identifier : AIDSLINE MED/99030030
- Birk M; Flock JI; Sonnerborg A; Sallberg M; Division of Clinical Virology, Karolinska Institute, Huddinge; University Hospital, Sweden.
- BACKGROUND: Despite the comparatively conserved nature of the HIV-1 gag gene, countless quasispecies of the p17 gene coexist in HIV-1-infected patients. It is not known if the minor genetic differences in quasispecies will affect immune recognition. OBJECTIVE: To characterize the antigenicity and immunogenicity of thr
- Experience with a cross-study endpoint review committee for AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS.
- AIDS. 1998 Oct 22;12(15):1983-90. Unique Identifier : AIDSLINE MED/99030031
- Green LA; Rhame FS; Price RW; Perlman DC; Capps LG; Sampson JH; Deyton LR; Schnittman SM; Fisher EJ; Bartsch GE; Krum EA; Neaton JD; CPCRA Statistical Center, University of Minnesota, Minneapolis; 55414, USA.
- OBJECTIVES: To describe the methods and results of a standardized system for clinical endpoint determination for defining and reviewing endpoints in clinical trials for HIV-infected individuals. DESIGN: A system was developed utilizing standard definitions for the 24 diagnoses or clinical events that serve as trial en
- HIV-1 RNA, CD4 cell count and the risk of progression to AIDS and death during treatment with HIV-1 reverse transcriptase inhibitors.
- AIDS. 1998 Oct 22;12(15):1991-7. Unique Identifier : AIDSLINE MED/99030032
- Staszewski S; DeMasi R; Hill AM; Dawson D; Klinikikum der Johann Wolfgang - Goethe Universitat, Frankfurt,; Germany.
- CONTEXT: There is little information available on the correlation between HIV-1 RNA level, CD4 cell count and the risk of progression to AIDS or death during treatment with reverse transcriptase inhibitors. OBJECTIVES: To define the correlation between HIV-1 RNA level, CD4 cell count and the 1 year risk of progression
- Efficacy and safety of stavudine and didanosine combination therapy in antiretroviral-experienced patients.
- AIDS. 1998 Oct 22;12(15):1999-2005. Unique Identifier : AIDSLINE MED/99030033
- Raffi F; Reliquet V; Auger S; Besnier JM; Chennebault JM; Billaud E; Michelet C; Perre P; Lafeuillade A; May T; Billaudel S; Department of Infectious Diseases, University Hospital, Nantes,; France.
- OBJECTIVES: To assess the efficacy, tolerance, and safety of combination antiretroviral therapy with didanosine and stavudine in HIV-infected patients with CD4+ cell counts > 100 x 10(6)/l and HIV plasma RNA > 10(4) copies/ml previously treated with o
- Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries.
- AIDS. 1998 Oct 22;12(15):2007-15. Unique Identifier : AIDSLINE MED/99030034
- Schmit JC; Van Laethem K; Ruiz L; Hermans P; Sprecher S; Sonnerborg A; Leal M; Harrer T; Clotet B; Arendt V; Lissen E; Witvrouw M; Desmyter J; De Clercq E; Vandamme AM; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
- OBJECTIVE: To study the prevalence of multiple dideoxynucleoside (ddN)-resistant (MddNR) HIV-1 in European patients under treatment with multiple ddN analogues, and to characterize MddNR strains genotypically and phenotypically. DESIGN AND METHODS: Blood samples from patients after > or = 6 months of treatment with mu
- Purified protein derivative testing and tuberculosis preventive therapy for HIV-infected patients in New York City.
- AIDS. 1998 Oct 22;12(15):2017-23. Unique Identifier : AIDSLINE MED/99030035
- Sackoff JE; Torian LV; Frieden TR; Brudney KF; Menzies IB; New York City Department of Health, Office of AIDS Research, New; York 10013, USA.
- OBJECTIVE: To determine whether Centers for Disease Control and Prevention recommendations for purified protein derivative (PPD) testing and tuberculosis (TB) preventive therapy for PPD-positive patients are implemented in HIV clinics. DESIGN: Retrospective medical chart review. SETTING: Ten hospital-based HIV clinics
- Detection of high nerve growth factor serum levels in AIDS-related and -unrelated Kaposi's sarcoma patients.
- AIDS. 1998 Oct 22;12(15):2025-9. Unique Identifier : AIDSLINE MED/99030036
- Pica F; Volpi A; Barillari G; Fraschetti M; Franzese O; Vullo V; Garaci E; Department of Experimental Medicine and Biochemical Sciences,; University Tor Vergata, Rome, Italy.
- OBJECTIVE: Nerve growth factor (NGF) is an autocrine survival factor for memory B lymphocytes. As functional B-cell deregulation is present during HIV infection, NGF serum levels were measured in HIV-infected patients and compared with the patients clinical features. DESIGN: Sera from 48 consecutive HIV-infected pati
- Changes in use of antiretroviral therapy in regions of Europe over time. EuroSIDA Study Group.
- AIDS. 1998 Oct 22;12(15):2031-9. Unique Identifier : AIDSLINE MED/99030037
- Kirk O; Mocroft A; Katzenstein TL; Lazzarin A; Antunes F; Francioli P; Brettle RP; Parkin JM; Gonzales-Lahoz J; Lundgren JD; Coordinating Centre for EuroSIDA, Hvidovre Hospital, Copenhagen,; Denmark.
- OBJECTIVES: To analyse use of antiretroviral therapy within Europe between 1994 and 1997. DESIGN: From September 1994, the EuroSIDA study (cohorts I-III) has prospectively followed unselected HIV-infected patients from 50 clinical centres in 17 European countries (total, 7230). METHODS: Patients under follow-up at hal
- Incidence of HIV and sexually transmitted diseases (STD) in a cohort of HIV-negative men who have sex with men (MSM).
- AIDS. 1998 Oct 22;12(15):2041-8. Unique Identifier : AIDSLINE MED/99030038
- Tabet SR; Krone MR; Paradise MA; Corey L; Stamm WE; Celum CL; Department of Medicine, School of Medicine, University of; Washington, Seattle, USA.
- OBJECTIVE: To determine the prevalence of sexually transmitted diseases (STD) and incidence of and risk factors for STD, including HIV-1, among a cohort of HIV-negative men who have sex with men (MSM). SETTING: Seattle, Washington, United States . PARTICIPANTS: Prospective cohort of 578
- Estimating HIV incidence from age-specific prevalence data: comparison with concurrent cohort estimates in a study of male factory workers, Harare, Zimbabwe.
- AIDS. 1998 Oct 22;12(15):2049-58. Unique Identifier : AIDSLINE MED/99030039
- Gregson S; Machekano R; Donnelly CA; Mbizvo MT; Anderson RM; Katzenstein DA; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Zoology Department, Oxford University, UK.
- OBJECTIVE: To compare HIV incidence estimates from cross-sectional age-specific prevalence data with concurrent cohort estimates and to examine the sensitivity of the estimates to changes in age-categorization and survivorship assumptions. METHODS: Two previously described methods of estimating HIV incidence from cros
- Prevalence and incidence rate of HIV, hepatitis B and C among drug users on methadone maintenance treatment in Geneva between 1988 and 1995.
- AIDS. 1998 Oct 22;12(15):2059-66. Unique Identifier : AIDSLINE MED/99030040
- Broers B; Junet C; Bourquin M; Deglon JJ; Perrin L; Hirschel B; Division of Infectious Diseases, University Hospital, Geneva,; Switzerland.
- OBJECTIVES: To evaluate the prevalence and incidence rates of infection with HIV, hepatitis B (HBV) and hepatitis C (HCV), in a cohort of drug users (DU) in Geneva, Switzerland . DESIGN: Prospective open cohort study. SETTING: Private methadone maintenance treatment (MMT) progr
- Classic Kaposi's sarcoma in Jews living in Israel, 1961-1989: a population-based incidence study.
- AIDS. 1998 Oct 22;12(15):2067-72. Unique Identifier : AIDSLINE MED/99030041
- Iscovich J; Boffetta P; Winkelmann R; Brennan P; Azizi E; Israel Cancer Registry, Ministry of Health, Jerusalem.
- BACKGROUND: The incidence of classic Kaposi s sarcoma (CKS) has been reported to be high in Jewish populations, mostly born in Eastern Europe. OBJECTIVE: To describe the incidence on CKS in Israeli Jews and to determine differences in incidence according to their geography origin. DESIGN: We analysed data on 1098 inci
- Identification of a novel HLA-A24-restricted cytotoxic T-lymphocyte epitope derived from HIV-1 Gag protein [letter]
- AIDS. 1998 Oct 22;12(15):2073-4. Unique Identifier : AIDSLINE MED/99030042
- Ikeda-Moore Y; Tomiyama H; Ibe M; Oka S; Miwa K; Kaneko Y; Takiguchi M
- Predictors of undetectable HIV plasma viral load in 250 HIV-positive women receiving care [letter]
- AIDS. 1998 Oct 22;12(15):2075-6. Unique Identifier : AIDSLINE MED/99030043
- Dickinson BP; Mitty JA; Mylonakis E; Rich JD; Merriman NA; Tashima KT; Carpenter CC; Flanigan TP
- False positives for HIV using commercial viral load quantification assays [letter]
- AIDS. 1998 Oct 22;12(15):2076-7. Unique Identifier : AIDSLINE MED/99030044
- de Mendoza C; Holguin A; Soriano V
- Protease inhibitor-associated hyperinsulinaemia [letter]
- AIDS. 1998 Oct 22;12(15):2077-9. Unique Identifier : AIDSLINE MED/99030045
- Martinez E; Casamitjana R; Conget I; Gatell JM
- Is treatment with ritonavir a risk factor for myocardial infarction in HIV-infected patients? [letter]
- AIDS. 1998 Oct 22;12(15):2079-80. Unique Identifier : AIDSLINE MED/99030046
- Eriksson U; Opravil M; Amann FW; Schaffner A
- Pharmacokinetic interaction between the proton pump inhibitor omeprazole and the HIV protease inhibitor indinavir [letter]
- AIDS. 1998 Oct 22;12(15):2080-2. Unique Identifier : AIDSLINE MED/99030047
- Burger DM; Hugen PW; Kroon FP; Groeneveld P; Brinkman K; Foudraine NA; Sprenger H; Koopmans PP; Hekster YA
- High incidence of nevirapine-associated rash in HIV-infected Chinese [letter]
- AIDS. 1998 Oct 22;12(15):2082-3. Unique Identifier : AIDSLINE MED/99030048
- Ho TT; Wong KH; Chan KC; Lee SS
- Reversal of abnormalities of neutrophil adhesion molecule expression in HIV infection following protease inhibitor therapy [letter]
- AIDS. 1998 Oct 22;12(15):2083-4. Unique Identifier : AIDSLINE MED/99030049
- Moore DA; Henderson D; Gotch F; Gazzard B
- Genotypic changes in DNA fingerprinting patterns of Mycobacterium tuberculosis strains from HIV-positive persons in Sardinia.
- AIDS. 1998 Oct 22;12(15):2084-6. Unique Identifier : AIDSLINE MED/99030050
- Sechi LA; Zanetti S; Dupre I; Aceti A; Sanguinetti M; Fadda G
- Secondary prophylaxis for Leishmania infection in an HIV-positive patient [letter]
- AIDS. 1998 Oct 22;12(15):2086-7. Unique Identifier : AIDSLINE MED/99030051
- Orlando G; Del Sorbo F; Corbellino M; Schiavini M; Cargnel A
- Participatory action research for sustaining individual and community change: a model of HIV prevention education.
- AIDS Educ Prev. 1998 Oct;10(5):387-402. Unique Identifier : AIDSLINE MED/99016318
- Stevens PE; Hall JM; University of Wisconsin-Milwaukee School of Nursing, Health; Maintenance Department 53201, USA.
- The authors describe the implementation, results, and evaluations of a participatory action research project in which they used qualitative methods to do HIV prevention education with lesbians and bisexual women. This grassroots project combined collective consciousness-raising, qualitative field interviewing, and ind
- Relationship of HIV testing and high-risk behaviors among clients in methadone maintenance treatment.
- AIDS Educ Prev. 1998 Oct;10(5):403-16. Unique Identifier : AIDSLINE MED/99016319
- Grella CE; Campos M; Anglin MD; UCLA Drug Abuse Research Center 90024, USA.
- This article reports on the association between frequency of HIV testing and high-risk behaviors among 339 individuals in the Los Angeles Enhanced Methadone Maintenance Project. Individuals who reported taking three or more HIV tests prior to entering treatment (45% of the sample) were more likely to know someone who
- Continuing medical education versus clinic-based STD and HIV education interventions for primary care service providers: replication and extension.
- AIDS Educ Prev. 1998 Oct;10(5):417-32. Unique Identifier : AIDSLINE MED/99016320
- Neff JA; Gaskill SP; Prihoda TJ; Weiner RV; Rydel KB; University of Tennessee College of Social Work, Nashville 37203,; USA. jneff1@utk.edu
- An evaluation of a 2-day sexually transmitted disease (STD) and HIV and AIDS curriculum for primary care providers is presented which compares large scale continuing medical education (CME) conferences with smaller clinic workshop (CW) models with regard to short-term (2-month) and long-term (10-month) program effects
- Effectiveness of a specialized vs. traditional AIDS education program attended by homeless and drug-addicted women alone or with supportive persons.
- AIDS Educ Prev. 1998 Oct;10(5):433-46. Unique Identifier : AIDSLINE MED/99016321
- Nyamathi A; Flaskerud J; Keenan C; Leake B; University of California at Los Angeles School of Nursing; 90095-6918, USA.
- This research examined the impact of including a supportive person on the outcomes of two culturally sensitive AIDS education programs, an education-only (traditional) program and a program combining education with self-esteem and coping enhancement (specialized). Research participants in this quasi-experimental study
- Perceived AIDS risk among adult arrestee injection drug users in Los Angeles county.
- AIDS Educ Prev. 1998 Oct;10(5):447-64. Unique Identifier : AIDSLINE MED/99016322
- Henson KD; Longshore D; Kowalewski MR; Anglin MD; Annon K; Department of Sociology and Anthropology, Loyola University,; Chicago, IL 60626, USA. khenson@luc.edu
- In this paper we examine the determinants of perceived risk for getting HIV and AIDS among adult Los Angeles arrestees reporting any lifetime injection drug use (N = 958). Our sample, drawn from the Drug Use Forecasting program, is 60% male and 40% female. Higher rates of reported risky drug and sexual behaviors than
- Acceptability of the female condom among STD clinic patients.
- AIDS Educ Prev. 1998 Oct;10(5):465-80. Unique Identifier : AIDSLINE MED/99016323
- el-Bassel N; Krishnan SP; Schilling RF; Witte S; Gilbert L; Social Intervention Group, Columbia University School of Social; Work, New York, NY 10025, USA. ne5@Columbia.edu
- This study examines the acceptability of the female condom among African American and Latino patients from two inner-city sexually transmitted disease (STD) clinics through focus group discussions. Prior to the initial focus group sessions, 90% (n = 90) had heard about the female condom, 8% (n = 8) had seen it, and 2%
- [Mycobacterium tuberculosis drug resistance in patients with HIV and pulmonary tuberculosis infections in Rome: 1987-1996]
- Ann Ital Med Int. 1998 Jul-Sep;13(3):139-45. Unique Identifier : AIDSLINE MED/99076666
- Palmieri F; Pellicelli AM; Girardi E; Rianda A; Bordi E; Festa A; Catania S; D'Amato C; II Divisione, IRCCS L. Spallanzani di Roma.
- A retrospective chart review was performed on 118 HIV infected patients with pulmonary tuberculosis hospitalized between 1987 and 1996 in a tertiary care center for Infectious Diseases in Rome. The aims of this study were: a) to evaluate global prevalence of and risk factors for drug-resistant Mycobacterium tuberculos
- Lactobacillus casei pneumonia and sepsis in a patient with AIDS. Case report and review of the literature.
- Ann Ital Med Int. 1998 Jul-Sep;13(3):180-2. Unique Identifier : AIDSLINE MED/99076674
- Rogasi PG; Vigano S; Pecile P; Leoncini F; U.O. Malattie Infettive, Azienda Ospedaliera Careggi di Firenze.
- Lactobacilli are ubiquitous gram-positive anaerobic rods present in the normal bacterial flora of the mouth, vagina and gastrointestinal tract. Although they are usually non pathogenic, serious infections have occasionally been described in transplant recipients or severely ill patients. Only 4 cases have been reporte
- Studies on the effects of truncating alpha-helix E' of p66 human immunodeficiency virus type 1 reverse transcriptase on template-primer binding and fidelity of DNA synthesis.
- Biochemistry. 1998 Nov 24;37(47):16636-44. Unique Identifier : AIDSLINE PDB/2HMI
- Menendez-Arias L; Centro de Biologia Molecular "Severo Ochoa", CSIC-Universidad; Autonoma de Madrid, Spain. lmenedez@cbm.uam.es
- The role of alpha-helix E of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) in template-primer binding and fidelity of DNA synthesis was investigated by using a series of mutant enzymes with deletions of 4, 8, 12, 16, and 20 amino acids at the C-terminal end of the 66 kDa s
- Genetic vaccination-induced immune responses to the human immunodeficiency virus protein Rev: emergence of the interleukin 2-producing helper T lymphocyte.
- Hum Gene Ther. 1998 Oct 10;9(15):2187-96. Unique Identifier : AIDSLINE MED/99008305
- Chan SY; Louie MC; Piccotti JR; Iyer G; Ling X; Yang ZY; Nabel GJ; Bishop DK; Department of Surgery, University of Michigan Medical Center, Ann; Arbor 48109, USA.
- Rev M10 is a trans-dominant negative inhibitor of HIV replication. Hence, stable transduction of CD4+ T cells with Rev M10 represents a novel gene therapy aimed at inhibiting HIV replication within these cells, thereby slowing the progression of AIDS. However, the immune system may recognize Rev M10 as foreign and tar
- Nonviral interferon alpha gene therapy inhibits growth of established tumors by eliciting a systemic immune response.
- Hum Gene Ther. 1998 Oct 10;9(15):2223-30. Unique Identifier : AIDSLINE MED/99008308
- Coleman M; Muller S; Quezada A; Mendiratta SK; Wang J; Thull NM; Bishop J; Matar M; Mester J; Pericle F; GeneMedicine, Inc., The Woodlands, TX 77381-4248, USA.
- A plasmid expression system encoding murine IFN-alpha4 and complexed with a protective interactive noncondensing polymeric (PINC) delivery system was used for in vivo immunotherapy treatment of an immunogenic murine renal cell carcinoma, Renca, and a nonimmunogenic mammary adenocarcinoma, TS/A. Mice bearing establishe
- Retroviral-mediated expression of an MHC class I-restricted T cell receptor in the CD8 T cell compartment of bone marrow-reconstituted mice.
- Unique Identifier : AIDSLINE MED/99008314
- Pogulis RJ; Hansen MJ; Pease LR
- The introduction of cloned T cell receptor (TCR) genes into bone marrow cells could provide a way to increase the frequency of tumor- or pathogen-specific cytotoxic T lymphocyte (CTL) precursors. We demonstrate here the ability of a retroviral vector to direct expression of a Valpha15/Vbeta13 MHC class I-restricted TC
- Expression and regulation of the thrombopoietin receptor variants MPLP and MPLK in PBMC.
- Cytokine. 1998 Oct;10(10):795-802. Unique Identifier : AIDSLINE MED/99030145
- Rollinger-Holzinger I; Griesser U; Pollak V; Zwierzina H; Centre Hospitalier de Luxembourg, Department of Hematology and; Oncology, L-1210 Luxembourg, Austria.
- The human c-mpl proto-oncogene encodes the receptor for thrombopoietin (TPO), which plays a central role in magakaryopoiesis and platelet production. Recent results showed that c-mpl mRNA expression is restricted to CD34(+) cells, megakaryocytes, and platelets. The authors analysed mRNA expression by reverse transcrip
- The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant.
- Blood. 1998 Dec 1;92(11):4036-9. Unique Identifier : AIDSLINE MED/99055520
- Sozzani S; Luini W; Bianchi G; Allavena P; Wells TN; Napolitano M; Bernardini G; Vecchi A; D'Ambrosio D; Mazzeo D; Sinigaglia F; Santoni A; Maggi E; Romagnani S; Mantovani A; Istituto di Ricerche Farmacologiche 'Mario Negri,' Milan, Italy.
- Kaposi s sarcoma (KS) lesions are characterized by a prominent leukocyte infiltrate composed of mononuclear phagocytes and T cells. KS-associated CD4(+) and CD8(+) cells showed predominantly a type II cytokine profile. The CC chemokine viral macrophage inflammatory protein-II (vMIP-II) encoded by the KS-associated her
- Immunophenotypic analysis of peripheral blood mononuclear cells undergoing in vitro apoptosis after isolation from human immunodeficiency virus-infected children.
- Blood. 1998 Dec 1;92(11):4230-7. Unique Identifier : AIDSLINE MED/99055542
- McCloskey TW; Bakshi S; Than S; Arman P; Pahwa S; North Shore University Hospital-New York University School of; Medicine, the Department of Pediatrics, the Division of; Allergy/Immunology, Manhasset, NY, USA.
- Lymphocytes of human immunodeficiency virus (HIV)-infected individuals undergo accelerated apoptosis in vitro, but the subsets of cells affected have not been clearly defined. This study examined the relationship between lymphocyte phenotype and apoptotic cell death in HIV-infected children by flow cytometry. Direct e
- Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor.
- Blood. 1998 Dec 1;92(11):4238-47. Unique Identifier : AIDSLINE MED/99055543
- Brossart P; Grunebach F; Stuhler G; Reichardt VL; Mohle R; Kanz L; Brugger W; University of Tubingen, Department of Hematology, Oncology and; Immunology, Tubingen, Germany.
- Recently it has been shown that dendritic cells (DC) can develop from peripheral blood monocytes when grown in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). However, it is unclear whether DC can also develop from monocytes in absence of these cytokines. We therefor
- [Intravitreal injection of cidofovir in cytomegalovirus retinitis]
- Ophthalmologe. 1998 Sep;95(9):602-6. Unique Identifier : AIDSLINE MED/99009776
- Kersten A; Althaus C; Hudde T; Pascha G; Schweykart N; Sundmacher R; Augenklinik, Heinrich-Heine-Universitat Dusseldof.
- BACKGROUND: CMV retinitis is the most common opportunistic ocular infection and the main cause of blindness in AIDS patients with a T-helper cell count
- Bacteremia and fungemia in patients with advanced human immunodeficiency virus (HIV) infection in Taiwan.
- J Formos Med Assoc. 1998 Oct;97(10):690-7. Unique Identifier : AIDSLINE MED/99047971
- Hung CC; Hsueh PR; Hsieh SM; Liu CJ; Chen MY; Luh KT; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, Taiwan.
- To understand the etiology and clinical outcome of bacterial and fungal sepsis in patients with advanced human immunodeficiency virus (HIV) infection in Taiwan , we conducted a prospective study of nonmycobacterial bacteremia and fun
- Conjunctival squamous cell carcinoma and intraepithelial neoplasia in AIDS patients in Congo Kinshasa.
- Bull Soc Belge Ophtalmol. 1998;268:135-41. Unique Identifier : AIDSLINE MED/99027790
- Kaimbo Wa Kaimbo D; Parys-Van Ginderdeuren R; Missotten L; Department of Ophthalmology, University of Kinshasa, D R Congo.
- PURPOSE: To determine the clinical characteristics of conjunctival squamous cell carcinoma and conjunctival intraepithelial neoplasia in AIDS patients. METHODS: A review of AIDS patients with biopsy-confirmed conjunctival squamous cell carcinoma and conjunctival intraepithelial neoplasia seen between 1994 and 1997. RE
- Combination therapy of resistant warts in a patient with AIDS.
- Dermatol Surg. 1998 Dec;24(12):1387-9. Unique Identifier : AIDSLINE MED/99082728
- Roark TR; Pandya AG; Department of Dermatology, University of Texas Southwestern; Medical Center, Dallas 75235-9069, USA.
- BACKGROUND: An AIDS patient on anti-HIV therapy consisting of two reverse transcriptase inhibitors had a low CD4+ lymphocyte count, a high HIV viral RNA load, and facial warts that were resistant to ablative therapy. OBJECTIVE: To find a regimen to treat resistant warts in an AIDS patient with a depressed CD4 count an
- A new candidate region for the positional cloning of the XLP gene.
- Eur J Hum Genet. 1998 Sep-Oct;6(5):509-17. Unique Identifier : AIDSLINE MED/99018684
- Bolino A; Yin L; Seri M; Cusano R; Cinti R; Coffey A; Brooksbank R; Howell G; Bentley D; Davis JR; Lanyi A; Huang D; Stark M; Creaven M; Bjorkhaug L; Heitzmann F; Lamartine J; Gaudi S; Sylla BS; Lenoir GM; Castagnola E; Giacchino R; Porta G; Franco B; Romeo G; et al; International XLP Consortium, Laboratorio di Genetica Molecolare,; Istituto Gaslini, Genova, Quarto, Italy.
- X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterised by selective susceptibility to Epstein-Barr virus and frequent association with malignant lymphomas chiefly located in the ileocecal region, liver, kidney and CNS. Taking advantage of a large bacterial clone contig, we obtained a
- Implications of the kinetics of zidovudine in the pregnant baboon following oral administration.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):433-40. Unique Identifier : AIDSLINE MED/99075299
- Garland M; Szeto HH; Daniel SS; Tropper PJ; Myers MM; Stark RI; Department of Pediatrics, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; mg71@columbia.edu
- Zidovudine (ZDV) therapy in pregnancy reduces mother-to-child transmission of HIV. The action of ZDV in the fetus is thought to be an important contributor to efficacy. Previous research in primates has demonstrated that continuous infusion of ZDV to the mother leads to sustained plasma concentrations in the fetus; ho
- Prechallenge high neutralizing antibodies and long-lasting immune reactivity to gp41 correlate with protection of rhesus monkeys against productive simian immunodeficiency virus infection or disease development.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):441-50. Unique Identifier : AIDSLINE MED/99075300
- Petry H; Dittmer U; Jones D; Farrar G; Wachter H; Fuchs D; Nisslein T; Jurkiewicz E; Hunsmann G; Stahl-Hennig C; Luke W; Department of Virology and Immunology, German Primate Center,; Gottingen.
- To investigate the protective efficacy of various gp130 vaccine preparations, rhesus monkeys were immunized with gp130 oligomers (O-gp130) or two different gp130-monomer preparations (M1-gp130; M2-gp130) and challenged with 50 MID50 of simian immunodeficiency virus (SIV)mac32H. Following challenge the control animals
- Safety and immunogenicity of HIV recombinant envelope vaccines in HIV-infected infants and children. National Institutes of Health-sponsored Pediatric AIDS Clinical Trials Group (ACTG-218).
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):451-61. Unique Identifier : AIDSLINE MED/99075301
- Lambert JS; McNamara J; Katz SL; Fenton T; Kang M; VanCott TC; Livingston R; Hawkins E; Moye J Jr; Borkowsky W; Johnson D; Yogev R; Duliege AM; Francis D; Gershon A; Wara D; Martin N; Levin M; McSherry G; Smith G; The Johns Hopkins University, Baltimore, Maryland, USA.; lambert@umbi.umd.edu
- Study objectives were to evaluate the safety and immunogenicity of three HIV recombinant glycoproteins in HIV-infected infants and children between 1 month and 18 years of age with asymptomatic (P-1) infection. Using Chiron rgp 120 (SF-2) 15 or 50 microg; MicroGeneSys rgp 160 (IIIB) 40 or 320 microg;
- Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P2C2 HIV study: the role of EBV shedding. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV-1 Infection (P2C2 HIV) Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):462-70. Unique Identifier : AIDSLINE MED/99075302
- Pitt J; Schluchter M; Jenson H; Kovacs A; LaRussa P; McIntosh K; Boyer P; Cooper E; Goldfarb J; Hammill H; Hodes D; Peavy H; Sperling R; Tuomala R; Shearer W; Department of Pediatrics, Columbia University College of; Physicians and Surgeons, New York, New York 10032, USA.
- The association of maternal and perinatal factors with mother-infant transmission of HIV-1 was examined in a prospective multicenter cohort of singleton live births to 508 HIV-1-infected women with children of known HIV-1 infection status (91 [18%] HIV-1-infected, 417 [82%] uninfected). From multivariate logistic regr
- Time course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):471-7. Unique Identifier : AIDSLINE MED/99075303
- Talesnik E; Vial PA; Labarca J; Mendez C; Soza X; Department of Pediatrics, Facultad de Medicina, Pontificia; Universidad Catolica de Chile, Santiago. reumatomed.puc.cl.
- The temporal course of the humoral immune response to T-cell-dependent and T-cell-independent type 2 antigens was evaluated in HIV-infected patients. In all, 26 seropositive patients were vaccinated with tetanus toxoid and 23-valent pneumococcal vaccines; total IgG and IgG1 antibodies to tetanus toxoid (Ttox) and tota
- Decay of HIV-1 DNA in patients receiving suppressive antiretroviral therapy.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):478-83. Unique Identifier : AIDSLINE +
- Izopet J; Salama G; Pasquier C; Sandres K; Marchou B; Massip P; Puel J; Laboratoire de Virologie, Hopital Purpan, Toulouse, France.; izopet@cict.fr
- We have examined the effect of potent antiretroviral regimens on the latent reservoirs of HIV-1. The HIV-1 DNA in the peripheral blood mononuclear cells (PBMC) of 10 patients with undetectable plasma HIV-1 RNA (
- A prospective study of community-acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):484-9. Unique Identifier : AIDSLINE MED/99075305
- Ssali FN; Kamya MR; Wabwire-Mangen F; Kasasa S; Joloba M; Williams D; Mugerwa RD; Ellner JJ; Johnson JL; Department of Medicine, Mulago Hospital and Makerere University,; Kampala, Uganda.
- Septicemia is a frequent cause of death in HIV-infected adults in developing countries. Additional prospective studies are needed to determine the etiology of bloodstream infections (BSI) in febrile HIV-infected adults and guide initial evaluation and treatment in this setting. We assessed the prevalence and etiology
- Nosocomial bloodstream infections in HIV-infected patients: attributable mortality and extension of hospital stay.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):490-7. Unique Identifier : AIDSLINE MED/99075306
- Tumbarello M; Tacconelli E; Donati KG; Leone F; Morace G; Cauda R; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy.
- A 3-year prospective matched case-control study was performed to investigate the potential risk factors, prognostic indicators, extension of hospital stay, and attributable mortality of nosocomial bloodstream infections in HIV-infected patients. Matching variables were: age, gender, number of circulating CD4+ T lympho
- A randomized trial of N-acetylcysteine for prevention of trimethoprim-sulfamethoxazole hypersensitivity reactions in Pneumocystis carinii pneumonia prophylaxis (CTN 057). Canadian HIV Trials Network 057 Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):498-505. Unique Identifier : AIDSLINE MED/99075307
- Walmsley SL; Khorasheh S; Singer J; Djurdjev O; Department of Medicine, University of Toronto, Ontario, Canada.; swalmsley@torhosp.toronto.on.ca
- Hydroxylamine derivatives of sulfamethoxazole may be the reactive metabolites that cause adverse reactions to trimethoprim-sulfamethoxazole (TMP-SMX). The increased frequency of reactions observed in HIV-positive individuals is hypothesized to be due to systemic glutathione deficiency and a decreased ability to scaven
- HIV seroincidence and risk factors among patients repeatedly tested for HIV attending sexually transmitted disease clinics in the United States, 1991 to 1996. STD Clinic HIV Seroincidence Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):506-12. Unique Identifier : AIDSLINE MED/99075308
- Weinstock H; Sweeney S; Satten GA; Gwinn M; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; hsw2@cdc.gov
- To assess the incidence of HIV infection and risk factors associated with HIV seroconversion among patients attending clinics for sexually transmitted diseases (STD), medical record reviews were conducted in 12 clinics in 7 U.S. cities. The records of all patients who initially tested negative for HIV from 1991 throug
- Seroprevalence of HTLV-I and HTLV-II among a cohort of HIV-infected women and women at risk for HIV infection. Women's Interagency HIV Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):513-8. Unique Identifier : AIDSLINE MED/99075309
- Telzak EE; Hershow R; Kalish LA; Hardy WD Jr; Zuckerman E; Levine A; Delapenha R; DeHovitz J; Greenblatt RM; Anastos K; Bronx-Lebanon Hospital Center, Albert Einstein College of; Medicine, Bronx, New York 10457, USA.
- OBJECTIVES: To determine the seroprevalence of, and risk factors for, HTLV-I and HTLV-II infection among HIV-infected women and women at high risk for HIV infection. DESIGN: Cross-sectional analysis of baseline data for women enrolled in the prospective Women s Interagency HIV Study (WIHS). METHODS: From October 1994
- Preventing discrimination against volunteers in prophylactic HIV vaccine trials: lessons from a phase II trial.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):519-26. Unique Identifier : AIDSLINE MED/99075310
- Sheon AR; Wagner L; McElrath MJ; Keefer MC; Zimmerman E; Israel H; Berger D; Fast P; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Rockville, Maryland,; USA. ASheon@umich.edu
- CONTEXT: Preventive HIV vaccines can temporarily cause uninfected individuals to have positive results on HIV testing. As preparations are underway to mount larger efficacy trials, the social risks of trial participation should be studied. OBJECTIVE: To describe frequency of HIV testing and discrimination among partic
- Epidemiologic evidence for time variation in HIV infectivity.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):527-35. Unique Identifier : AIDSLINE MED/99075311
- Shiboski SC; Padian NS; Department of Epidemiology and Biostatistics, University of; California-San Francisco, 94143-0560, USA. steve@biostat.ucsf.edu
- Data from three epidemiologic studies of heterosexual transmission of HIV among monogamous couples are used to assess evidence for time variation in HIV infectivity, possibly related to varying levels of infectiousness following infection in the primary infected partner. Analyses are based on statistical techniques th
- HTLV-I-associated myelopathy/tropical spastic paraparesis in Brazil: a nationwide survey. HAM/TSP Brazilian Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):536-41. Unique Identifier : AIDSLINE MED/99075312
- Araujo AQ; Andrade-Filho AS; Castro-Costa CM; Menna-Barreto M; Almeida SM; Hospital Evandro Chagas, IOC/Fiocruz, Rio de Janeiro, Brazil.; hechtlv@fiocruz.br
- To study the epidemiology of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Brazil , we conducted a nationwide survey between March 1994 and April 1995. Five centers from three regions of the country participated, enrolling 163 patients. Most patients came fr
- Simian T-lymphotropic virus type I infection among wild-caught Indonesian pig-tailed macaques (Macaca nemestrina).
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):542-5. Unique Identifier : AIDSLINE MED/99075313
- Richards AL; Giri A; Iskandriati D; Pamungkas J; Sie A; Rosen L; Anthony RL; Franchini G; Department of Immunology, U.S. Naval Medical Research Unit No. 2,; Jakarta, Indonesia. arichards@nsh10.med.navy.mil
- Evidence for the presence of simian T-lymphotropic viruses (STLV-I) was identified in live-caught pig-tailed macaques from two locations in southern Sumatra, Indonesia . Of 60 animals tested, 13.3% of the animals showed seroreactivity to HTLV-I/II enzyme-linked immunosorbent assa
- Effect of coinfection with hepatitis G virus on HIV disease progression in hemophilic men [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):546-8. Unique Identifier : AIDSLINE MED/99075314
- Sabin CA; Devereux H; Kinson Z; Griffioen A; Brown D; Dusheiko G; Lee CA
- HTLV-I/II antibodies among three different Indian groups from Paraguay [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15;19(5):548-9. Unique Identifier : AIDSLINE MED/99075315
- de Cabral MB; Vera ME; Samudio M; Arias AR; Cabello A; Moreno R; Zapiola I; Bouzas MB; Muchinik G
- Protocol for initial evaluation of occupational exposure to HIV and initiation of antiretroviral prophylaxis.
- Am J Health Syst Pharm. 1998 Sep 15;55(18):1921-4. Unique Identifier : AIDSLINE MED/99000951
- Shinohara YT; Edwards K; Thompson-Bowers J; Department of Pharmacy, Naval Medical Center San Diego, CA; 92134-5000, USA.
- Interleukin 4 and interferon-gamma secretion by antigen and mitogen-stimulated mononuclear cells in the hyper-IgE syndrome: no TH-2 cytokine pattern.
- Ann Allergy Asthma Immunol. 1998 Nov;81(5 Pt 1):443-7. Unique Identifier : AIDSLINE MED/99075381
- Rodriguez MF; Patino PJ; Montoya F; Montoya CJ; Sorensen RU; Garcia de Olarte D; Immunology Laboratory, School of Medicine, University of; Antioquia, Medellin, Columbia.
- BACKGROUND: Enhanced production of TH-2 cytokines plays a key role in increased IgE production in allergic diseases. Reports about the cytokine profile secreted by peripheral blood mononuclear cells of patients with hyper-IgE syndrome, however, are controversial, suggesting alternative causes for increased IgE product
- HIV-induced immunopathogenesis.
- Immunity. 1998 Nov;9(5):587-93. Unique Identifier : AIDSLINE MED/99060914
- Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-1360,; USA. Gene_Shearer@nih.gov
- Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.
- Immunity. 1998 Nov;9(5):627-35. Unique Identifier : AIDSLINE MED/99060918
- Ranger AM; Oukka M; Rengarajan J; Glimcher LH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115-6017, USA.
- Nuclear factor of activated T cells (NFAT) is a critical regulator of early gene transcription in response to TCR-mediated signals. Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling coupled with increased resistance
- IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.
- Immunity. 1998 Nov;9(5):669-76. Unique Identifier : AIDSLINE MED/99060922
- Lodolce JP; Boone DL; Chai S; Swain RE; Dassopoulos T; Trettin S; Ma A; Department of Medicine, The University of Chicago, Illinois; 60637, USA.
- The IL-15 receptor alpha subunit (IL-15Ralpha) mediates high-affinity binding of IL-15, a pleiotropic cytokine implicated in the development of innate immune cells. We have generated IL-15Ralpha null (IL-15Ralpha-/-) mice to understand the role of IL-15Ralpha in immune development and function. IL-15Ralpha-/- mice are
- Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells.
- Immunity. 1998 Nov;9(5):711-20. Unique Identifier : AIDSLINE MED/99060926
- Bonfoco E; Stuart PM; Brunner T; Lin T; Griffith TS; Gao Y; Nakajima H; Henkart PA; Ferguson TA; Green DR; Division of Cellular Immunology, La Jolla Institute for Allergy; and Immunology, San Diego, California 92121, USA.
- Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)-induced peripheral deletion of Vbeta8+ T cells. We found that peripheral deletion was defective in radiation chimeras with non-functional tissue FasL, regardless of the FasL status of the bone marrow-derived cells. SEB induced a dr
- Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism.
- Immunity. 1998 Nov;9(5):745-55. Unique Identifier : AIDSLINE MED/99060929
- Ouyang W; Ranganath SH; Weindel K; Bhattacharya D; Murphy TL; Sha WC; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, Missouri 63110, USA.
- Recently, the transcription factor GATA-3 was shown to be selectively expressed in Th2 but not Th1 cells and to augment Th2-specific cytokines. Here, we show that loss of GATA-3 expression by developing Th1 cells requires IL-12 signaling through Stat4 and does not simply result from an absence of IL-4. Moreover, we de
- Histopathological study of the role of CD4- and CD8-positive T cells on bone resorption induced by Escherichia coli endotoxin.
- Unique Identifier : AIDSLINE MED/98297976
- Hara Y; Ukai T; Yoshimura A; Shiku H; Kato I
- The purpose of this study was to clarify the involvement of CD4+ and CD8+ T cells on bone resorption induced by Escherichia coli endotoxin. Two kinds of monoclonal antibodies, anti-CD4 and/or
- Quantitative hepatitis B virus DNA assessment by the limiting-dilution polymerase chain reaction in chronic hepatitis B patients: evidence of continuing viral suppression with longer duration and higher dose of lamivudine therapy.
- J Viral Hepat. 1998 Sep;5(5):307-12. Unique Identifier : AIDSLINE MED/99012006
- Honkoop P; de Man RA; Niesters HG; Main J; Nevens F; Thomas HC; Fevery J; Tyrrell DL; Schalm SW; Department of Hepatogastroenterology, Erasmus University Hospital; Rotterdam, The Netherlands.
- Lamivudine , a novel cytosine analogue, exhibits potent antiviral activity against hepatitis B virus (HBV) in vitro and in vivo. The standard HBV DNA hybridization assay used in phase II clinical studies has a low sensitivity, the detection limit of HB
- The continuing epidemic [letter]
- J Can Dent Assoc. 1998 Nov;64(10):678, 680. Unique Identifier : AIDSLINE MED/99071516
- Hardie J
- Private business: the uptake of confidential HIV testing in remote aboriginal communities on the Anangu Pitjantjatjara Lands.
- Aust N Z J Public Health. 1998 Oct;22(6):700-3. Unique Identifier : AIDSLINE MED/99065815
- Miller PJ; Torzillo PJ; Nganampa Health Council, South Australia, Alice Springs, Northern; Territory. pjmnhc@ozemail.com.au
- BACKGROUND AND METHODS: Despite a concentration of risk factors for HIV transmission, many remote Aboriginal communities in central Australia have a low uptake of HIV testing. We studied the uptake of HIV testing in six clinics in remote Aboriginal communities following the intr
- Malaria vs. AIDS: time to re-evaluate priorities [letter]
- Can J Public Health. 1998 Sep-Oct;89(5):314. Unique Identifier : AIDSLINE MED/99031458
- Hodgson K
- Malaria vs. AIDS: time to re-evaluate priorities [letter]
- Can J Public Health. 1998 Sep-Oct;89(5):314. Unique Identifier : AIDSLINE MED/99031459
- Rudolph R
- Pneumatosis intestinalis in AIDS-associated chronic intestinal cryptosporidiosis: a benign course in a severe-looking disease [letter]
- Eur Radiol. 1998;8(8):1499. Unique Identifier : AIDSLINE MED/99070356
- Herneth AM; Pokieser P; Kettenbach J; Rappersberger K; Mostbeck G
- Gene therapy: different strategies for different applications. American Society of Gene Therapy: First Annual Meeting, Seattle, Washington, USA, 28-31 May 1998.
- Mol Med Today. 1998 Sep;4(9):374-5. Unique Identifier : AIDSLINE MED/99092686
- Caplen NJ; Clinical Gene Therapy Branch, NHGRI, NIH, Bethesda, MD 20892,; USA. ncaplen@nhgri.nih.gov
- Generation of CD8+ and CD4+ T-cell response to dendritic cells genetically engineered to express the MART-1/Melan-A gene.
- Cancer Res. 1998 Dec 1;58(23):5305-9. Unique Identifier : AIDSLINE MED/99065306
- Perez-Diez A; Butterfield LH; Li L; Chakraborty NG; Economou JS; Mukherji B; Department of Medicine, University of Connecticut Health Center,; Farmington 06030, USA.
- Both CD8+ and CD4+ T cells have demonstrated roles in antitumor immune response in many animal tumor systems. In many human tumor systems, although abundant literature exists on the evidence of tumor antigen-specific CD8+ CTL response, only limited information is available on tumor antigen-specific CD4+ T-cell respons
- EblacZ tumor dormancy in bone marrow and lymph nodes: active control of proliferating tumor cells by CD8+ immune T cells.
- Cancer Res. 1998 Dec 1;58(23):5439-46. Unique Identifier : AIDSLINE MED/99065329
- Muller M; Gounari F; Prifti S; Hacker HJ; Schirrmacher V; Khazaie K; Tumor Immunology Program, German Cancer Research Center; (Deutsches Krebsforschungzentrum), Heidelberg.
- A well-defined lacZ gene tagged DBA/2 lymphoma (EblacZ) was used to examine the role of host immune responses in controlling tumor dissemination and persistence, as well as metastasis. In s.c. and intra-ear pinna-inoculated mice, low numbers of EblacZ cells homed to the bone marrow and lymph nodes. The frequency of bo
- Synthesis of sulfonated amino-polysaccharides having anti-HIV and blood anticoagulant activities.
- Carbohydr Res. 1998 Nov;312(1-2):1-8. Unique Identifier : AIDSLINE MED/99053169
- Hattori K; Yoshida T; Nakashima H; Premanathan M; Aragaki R; Mimura T; Kaneko Y; Yamamoto N; Uryu T; Polymer Science Department, Graduate School of Science, Hokkaido; University, Sapporo, Japan.
- Sulfonated 3-amino-3-deoxy-(1-->6)-alpha-D-allopyranans were synthesized to elucidate the relationship between structure and such specific biological activities as anti-HIV and blood anticoagulant activities. Ring-opening copolymerization of 1,6-anhydro-3-azido-2,4-di-O-benzyl-3-deoxy-beta-D-allopyranose 1 with 1,6-an
- Priming or tolerization of the B- and Th2-dependent immune response by the oral administration of OVA-DNP is determined by the antigen dosage.
- Cell Immunol. 1998 Nov 25;190(1):1-11. Unique Identifier : AIDSLINE MED/99045505
- Franco L; Benedetti R; Ferek GA; Massouh E; Flo J; Faculty of Exact and Natural Sciences, University of Buenos; Aires, Buenos Aires, Argentina.
- In the present report we established antigen dosages that induce oral tolerance of Th1 and Th2 lymphocytes or instead prime B- and Th2-dependent immune response and induce the tolerance of Th1 lymphocytes. Using different hapten-carrier systems, we found that low doses of OVA-DNP administered orally primed B and Th2 c
- Long-term analysis of allergen-specific T cell clones from patients with asthma treated with allergen rush immunotherapy.
- Cell Immunol. 1998 Nov 25;190(1):43-50. Unique Identifier : AIDSLINE MED/99045509
- Oda N; Yamashita N; Minoguchi K; Takeno M; Kaneko S; Sakane T; Adachi M; First Department of Internal Medicine, Showa University, Tokyo,; Japan.
- Rush immunotherapy (RI), a modified allergen-specific immunotherapeutic procedure, is an effective treatment for extrinsic (atopic) asthma, although the precise mechanism of its action is unclear. We have thus investigated the effect of RI on T cell response in seven mite-allergen-sensitive asthmatic patients who were
- Pattern of immune response to GP43 from Paracoccidioides brasiliensis in susceptible and resistant mice is influenced by antigen-presenting cells.
- Cell Immunol. 1998 Nov 25;190(1):68-76. Unique Identifier : AIDSLINE MED/99045512
- de Almeida SR; de Moraes JZ; de Camargo ZP; Gesztesi JL; Mariano M; Lopes JD; Departamento de Microbiologia, Imunologia e Parasitologia, Sao; Paulo, Brazil.
- Paracoccidioidomycosis (PCM), endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve to different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. In the murine model, A/Sn and B10.A isogenic strains of
- Immunostimulatory DNA is a potent mucosal adjuvant.
- Unique Identifier : AIDSLINE MED/99045513
- Horner AA; Ronaghy A; Cheng PM; Nguyen MD; Cho HJ
- Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice.
- Cell Immunol. 1998 Nov 25;190(1):83-9. Unique Identifier : AIDSLINE MED/99045514
- Samoilova EB; Horton JL; Chen Y; Department of Molecular and Cellular Engineering, University of; Pennsylvania School of Medicine, Philadelphia, Pennsylvania,; 19104, USA.
- Intercellular adhesion molecule (ICAM)-1, or CD54, is a member of the immunoglobulin superfamily that binds to lymphocyte function-associated antigen-1 and macrophage-1 antigen. ICAM-1:LFA-1/Mac-1 interaction may be involved in both activation and extravasation of leukocytes. To determine the roles of ICAM-1 in the de
- Human papillomavirus, Epstein-Barr virus, human herpesvirus 8 and human cytomegalovirus involvement in salivary gland tumours.
- Oral Oncol. 1998 Sep;34(5):391-5. Unique Identifier : AIDSLINE MED/99078340
- Atula T; Grenman R; Klemi P; Syrjanen S; MediCity Research Laboratory, Faculty of Medicine, University of; Turku, Finland.
- Human papillomaviruses (HPV) are involved in the etiology of both benign and malignant epithelial lesions. The occurrence of HPV types 16 and 18 in gynecological squamous cell carcinomas is also well known. Of the herpesviruses, Epstein-Barr virus (EBV) is associated with, for example, undifferentiated nasopharyngeal
- Participation in clinical trials among women living with HIV in Canada. Canadian Women's HIV Study Group [see comments]
- CMAJ. 1998 Dec 1;159(11):1359-65. Unique Identifier : AIDSLINE MED/99078197
- Hankins C; Lapointe N; Walmsley S; Infectious Diseases Unit, Montreal Regional Public Health; Department, Que. md77@musica.mcgill.ca
- BACKGROUND: To describe participation in clinical trials among HIV-positive women enrolled since 1993 in the Canadian Women s HIV Study, a prospective open cohort study. METHODS: All HIV-positive women being followed at hospital-based or community-based clinics at 28 sites in 11 Canadian cities were eligible to partic
- The evolution of clinical trials: inclusion and representation [editorial; comment]
- CMAJ. 1998 Dec 1;159(11):1373-4. Unique Identifier : AIDSLINE MED/99078199
- Rochon PA; Berger PB; Gordon M
- A simplified assay for screening of drug resistance of cell-associated cytomegalovirus strains.
- J Clin Virol. 1998 Jul 24;11(1):29-37. Unique Identifier : AIDSLINE MED/98456585
- Prix L; Maierl J; Jahn G; Hamprecht K; Department of Medical Virology and Epidemiology of Viral; Diseases, University of Tubingen, Germany.
- BACKGROUND: Conventional phenotypic drug resistance determination of cell-free clinical human cytomegalovirus (HCMV) isolates is usually very laborious and may take 8-12 weeks, since serially passages of slowly growing viral isolates in tissue cultures are required to obtain a suff
- Evaluation of epidemiological and serological predictors of human immunodeficiency virus type-1 (HIV-1) infection among high risk professional blood donors with western blot indeterminate results.
- J Clin Virol. 1998 Jul 24;11(1):39-49. Unique Identifier : AIDSLINE MED/98456586
- Chattopadhya D; Aggarwal RK; Baveja UK; Doda V; Kumari S; AIDS Reference Laboratory, Division of AIDS, National Institute; of Communicable Diseases, New Delhi, India.
- BACKGROUND: Indeterminate pattern of results in Western blot (WBI) for human immunodeficiency virus type-1 (HIV-1) infection may represent early HIV-1 infection or may be non-specific in origin. This issue can be resolved by follow up testing upto at least 6 months resulting in psychological distress as well as in hig
- Use of the human cytomegalovirus (HCMV) antigenemia assay for diagnosis and monitoring of HCMV infections and detection of antiviral drug resistance in the immunocompromised.
- J Clin Virol. 1998 Jul 24;11(1):51-60. Unique Identifier : AIDSLINE MED/98456587
- Baldanti F; Revello MG; Percivalle E; Gerna G; Servizio di Virologia, IRCCS Policlinico S. Matteo, Pavia, Italy.
- BACKGROUND: Quantification of viral load in blood has proven to be helpful in the follow-up of disseminated HCMV infections in immunocompromised patients. OBJECTIVES: (i) To describe the antigenemia assay and its optimization and (ii) to analyze the use of the antigenemia assay for the diagnosis and monitoring of HCMV
- Sexually transmitted diseases and human immunodeficiency virus infection: cause, effect, or both? [editorial; comment]
- Int J Infect Dis. 1998 Jul-Sep;3(1):1-4. Unique Identifier : AIDSLINE MED/99051464
- Cohen MS; Miller WC
- The infectiousness of the index case and the susceptibility of the exposed host mediate the sexual transmission of human immunodeficiency virus (HIV). Infectiousness of the index case is determined by the inoculum of HIV and viral factors that favor transmission. Persons with primary infection, late stage disease, or
- Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals.
- Int J Infect Dis. 1998 Jul-Sep;3(1):39-47. Unique Identifier : AIDSLINE MED/99051471
- Shafran SD; Division of Infectious Diseases, Department of Medicine,; University of Alberta, Walter C. Mackenzie Health Science Centre,; Edmonton, Alberta, Canada.
- Disseminated Mycobacterium avium complex (DMAC) infection is a common complication of advanced HIV disease, and is an independent predictor of mortality. The clinical features of DMAC infection are fever, weight loss, abdominal pain, anemia, elevated serum alkaline phosphatase, and elevated serum lactate dehydrogenase
- Epidemiology and management of penicilliosis in human immunodeficiency virus-infected patients.
- Int J Infect Dis. 1998 Jul-Sep;3(1):48-53. Unique Identifier : AIDSLINE MED/99051472
- Sirisanthana T; Supparatpinyo K; Department of Medicine, Faculty of Medicine, Chiang Mai; University Hospital, Chiang Mai, Thailand.
- Penicillium marneffei is a dimorphic fungus that can cause systemic mycosis in humans. It is endemic in Southeast Asia, the Guangxi province of China , Hong Kong , and
- Herpes simplex type II and Mycoplasma genitalium as risk factors for heterosexual HIV transmission: report from the heterosexual HIV transmission study [see comments]
- Int J Infect Dis. 1998 Jul-Sep;3(1):5-11. Unique Identifier : AIDSLINE MED/99051465
- Perez G; Skurnick JH; Denny TN; Stephens R; Kennedy CA; Regivick N; Nahmias A; Lee FK; Lo SC; Wang RY; Weiss SH; Louria DB; Division of Infectious Diseases, Department of Internal Medicine,; St. Michael's Medical Center, Newark, New Jersey, USA.
- OBJECTIVES: Two hundred twenty-four human immunodeficiency virus (HIV) discordant couples (one HIV negative, one HIV positive) were compared with 78 seroconcordant heterosexually infected couples with HIV with regard to sexually transmitted diseases. METHODS: Serologic testing and cultures were used to determine expos
- [Ramsay Hunt syndrome associated with eosinophilic pneumonia]
- Nihon Kokyuki Gakkai Zasshi. 1998 Jun;36(6):531-4. Unique Identifier : AIDSLINE MED/98426612
- Kodama K; Department of Internal Medicine, Minamitane Town Hospital,; Kagoshima, Japan.
- A 66-year-old woman was admitted to the hospital because of dry coughing. Ten days before admission, the patient had suffered from facial palsy accompanying otic zoster infection (Ramsay Hunt syndrome). Acyclovir was given, and during the two weeks after admission, the facial pa
- Chronic plasma cell endometritis in hysterectomy specimens of HIV-infected women: a retrospective analysis.
- Infect Dis Obstet Gynecol. 1998;6(4):186-90. Unique Identifier : AIDSLINE MED/99028786
- Kerr-Layton JA; Stamm CA; Peterson LS; McGregor JA; Department of Obstetrics and Gynecology, University of Colorado; School of Medicine, Denver Health Medical Center, CO, USA.
- OBJECTIVE: Abnormal uterine bleeding is a common and troublesome problem in human immunodeficiency virus (HIV)-infected women. We sought to evaluate endometrial pathology among HIV-infected women requiring hysterectomy to explore if endometritis may be common among these patients. METHODS: We performed a retrospective
- In vitro release of cytarabine from swellable matrices of CnEmCn triblock copolymers.
- J Controlled Release. 1998 Dec 4;56(1-3):1-6. Unique Identifier : AIDSLINE MED/99019822
- Ameri M; Collett JH; Attwood D; Booth C; Manchester Polymer Centre, School of Pharmacy and Pharmaceutical; Sciences and Department of Chemistry, University of Manchester,; Manchester M13 9PL, UK.
- Matrices loaded with cytarabine were prepared by compression of the tailor made triblock copolymers C17E227C17 and C17E454C17 (where C=methylene and E=oxyethylene). Observations of the swelling characteristics of copolymer matrices on immersion in distilled water indicated an increase in the thickness of the gel layer
- Pleural body cavity-based lymphoma.
- Ann Diagn Pathol. 1998 Apr;2(2):127-34. Unique Identifier : AIDSLINE MED/99063888
- Perez MT; Cabello-Inchausti B; Viamonte M Jr; Nixon D; Arkadi M. Rywlin Department of Pathology and Laboratory Medicine,; Mount Sinai Medical Center, Miami, FL, USA.
- We report a case of recurrent body cavity-based non-Hodgkin s lymphoma in a patient with advanced acquired immunodeficiency syndrome who presented with bilateral pleural effusions, without evidence of an associated tumor mass. The lymphoma cells were large and pleomorphic, lacking
- Pathology of human immunodeficiency virus infection: infectious conditions.
- Ann Diagn Pathol. 1998 Jun;2(3):181-94. Unique Identifier : AIDSLINE MED/99063896
- Lewin-Smith MR; Klassen MK; Frankel SS; Nelson AM; Department of Infectious and Parasitic Disease Pathology, Armed; Forces Institute of Pathology, Washington, DC, USA.
- Infection with the human immunodeficiency virus (HIV) and the subsequent derangement of host immunity place affected patients at risk for secondary infections. Some of the secondary pathogens occur with such frequency or are so rare in the non-immunosuppressed population that they have become part of the Centers for D
- Cutaneous tuberculosis: a rare presentation in an immigrant.
- J Travel Med. 1998 Sep;5(3):131-4. Unique Identifier : AIDSLINE MED/99055457
- Gulisano G; Mariani L; Chair of Tropical Medicine, University of Catania, Italy.
- The increased incidence of tubercular diseases in industrialized countries appears to be due to several factors, including development of resistance to the most commonly used specific chemotherapeutic substances, unsuitable control programmes, HIV infection, the increased influx of immigrants, and homelessness. Differ
- Dental precautions for travelers [letter]
- J Travel Med. 1998 Sep;5(3):159-. Unique Identifier : AIDSLINE MED/99090683
- Florence E; Van Gompel A; Colebunders R
- Azidothymidine resistance of H9 human T-cell lymphoma cells is associated with decreased sensitivity to antitumor agents and inhibition of apoptosis.
- Unique Identifier : AIDSLINE MED/99067723
- Cinatl J Jr; Kotchetkov R; Groschel B; Cinatl J; Driever PH; Kabickova H
- Atopic dermatitis apparently caused by type 2 CD8+ T cells in an AIDS patient.
- Clin Exp Dermatol. 1998 May;23(3):121-2. Unique Identifier : AIDSLINE MED/99078734
- Ishii N; Takahashi K; Sugita Y; Nakajima H; Department of Dermatology, Yokohama City University School of; Medicine, Japan.
- A patient with atopic dermatitis and acquired immune deficiency syndrome (AIDS) had demonstrated blood eosinophilia, high levels of serum IgE and intracytoplasmic IL-4 in the CD8+ but not in the CD4+ cells, decreased numbers of CD4+ cells, and low levels of IL-2 in bot
- Does HIV status influence the anatomy of anal fistulas?
- Dis Colon Rectum. 1998 Dec;41(12):1529-33. Unique Identifier : AIDSLINE MED/99075677
- Manookian CM; Sokol TP; Headrick C; Fleshner PR; Division of Colon and Rectal Surgery, Cedars-Sinai Medical; Center, Los Angeles, California, USA.
- PURPOSE: Although anorectal disease is common in human immunodeficiency virus-positive patients, little is known about the type and anatomic distribution of anal fistulas in this patient group. The aim of this study was to compare anatomic characteristics of anal fistulas in human immunodeficiency virus-positive patie
- [Fulminant hepatitis in the course of antitubercular treatment (apropos of 2 cases)]
- Dakar Med. 1995;40(2):129-31. Unique Identifier : AIDSLINE MED/99044307
- Mbaye PS; Talarmin F; Sane M; Eladari D; Klotz F; Services Medicaux, Hopital Principal de Dakar, Senegal.
- We report two cases of fulminant hepatitis induced by antitubercular drugs. The mechanism is both immunoallergic and toxic. The fatal case appears in patient with acquired immunodeficiency syndrome. Liver tests must be realized during antitubercular treatment, that is difficult in sub-Saharan Africa.
- Insulin-like growth factor-I resistance.
- Endocr Rev. 1998 Oct;19(5):625-46. Unique Identifier : AIDSLINE MED/99010176
- Jain S; Golde DW; Bailey R; Geffner ME; Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
- Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis.
- Eur J Immunol. 1998 Dec;28(12):3893-903. Unique Identifier : AIDSLINE MED/99077142
- Di Rosa F; Francesconi A; Di Virgilio A; Finocchi L; Santilio I; Barnaba V; Fondazione Andrea Cesalpino, I Clinica Medica, Universita La; Sapienza, Rome, Italy. francesca_di_rosa@iol.it
- The mechanisms underlying spontaneous remission of autoimmune diseases are presently unknown, though regulatory T cells are believed to play a major role in this process. We tested the hypothesis that Th2 and/or other T cell regulatory cytokines cause the spontaneous remission of experimental allergic encephalomyeliti
- Parasite dose determines the Th1/Th2 nature of the response to Leishmania major independently of infection route and strain of host or parasite.
- Eur J Immunol. 1998 Dec;28(12):4020-8. Unique Identifier : AIDSLINE MED/99077154
- Menon JN; Bretscher PA; Department of Microbiology and Immunology, University of; Saskatchewan, Saskatoon, Canada.
- Leishmania major causes cutaneous leishmaniasis in mice and man. Infection of mice with relatively low or high numbers of parasites leads respectively to parasite containment, associated with a Th1, cell-mediated response, or progressive disease, associated with a Th2, antibody response in all circumstances studied. T
- Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages.
- Eur J Immunol. 1998 Dec;28(12):4062-70. Unique Identifier : AIDSLINE MED/99077158
- Huang FP; Niedbala W; Wei XQ; Xu D; Feng GJ; Robinson JH; Lam C; Liew FY; Department of Immunology, University of Glasgow, GB.
- We have previously reported that mice lacking inducible nitric oxide synthase (NOS2) developed enhanced Th1 cell responses. We now investigated the mechanism by which NO modulates Th1 cells differentiation. Peritoneal macrophages from NOS2-deficient mice infected with Leishmania major in vivo or stimulated with IFN-ga
- A novel dendritic cell population in human blood: one-step immunomagnetic isolation by a specific mAb (M-DC8) and in vitro priming of cytotoxic T lymphocytes.
- Eur J Immunol. 1998 Dec;28(12):4084-93. Unique Identifier : AIDSLINE MED/99077160
- Schakel K; Mayer E; Federle C; Schmitz M; Riethmuller G; Rieber EP; Institute for Immunology, Medical Faculty, Technical University; of Dresden, Germany.
- Originating from a common progenitor cell, dendritic cells (DC) appear to develop along early branched pathways into various yet ill-defined subpopulations residing at various sites throughout the body where they capture and present antigen in the most professional fashion. Here we give evidence for a unique subpopula
- Delayed kinetics of tumor necrosis factor-mediated bystander lysis by peptide-specific CD8+ cytotoxic T lymphocytes.
- Eur J Immunol. 1998 Dec;28(12):4162-9. Unique Identifier : AIDSLINE MED/99077168
- Smyth MJ; Sedgwick JD; Cellular Cytotoxicity Laboratory, The Austin Research Institute,; Heidelberg, Australia. m.smyth@ari.unimelb.edu.au
- Mouse CD8+ CTL reactive with an H-2Db presented 9-mer peptide of the human papilloma virus 16 (HPV-16) protein E749-57 (RAHYNIVTF) were generated from the splenocytes of wild-type C57BL/6 (B6), B6.perforin-deficient, B6.gld or B6.TNF-deficient mice. In short-term (4 h) assays, CTL from B6, B6.TNF-deficient and B6.gld
- Characterization of T cell-expressed chimeric receptors with antibody-type specificity for the CD4 binding site of HIV-1 gp120.
- Unique Identifier : AIDSLINE MED/99077170
- Bitton N; Verrier F; Debre P; Gorochov G
- Chimeric T cell receptors (cTCR) with an antibody specificity have been proposed in several models as a combination of antibody and cellular immunotherapy without MHC restriction. Such a tool could be of a limited use in HIV infection because of the great variability of the virus. The human single-chain antibody (ScFv
- Activation of nuclear factor-kappaB in macrophages by mycoplasmal lipopeptides.
- Eur J Immunol. 1998 Dec;28(12):4207-12. Unique Identifier : AIDSLINE MED/99077173
- Sacht G; Marten A; Deiters U; Sussmuth R; Jung G; Wingender E; Muhlradt PF; Immunobiology Research Group, Gesellschaft fur Biotechnologische; Forschung mbH, Braunschweig, Germany.
- Mycoplasmas are potent macrophage stimulators. The active principle are lipopeptides or lipoproteins with a characteristic N-terminal S-[dihydroxypropyl]-cysteinyl group bearing two ester-bound fatty acids and lacking the amide-bound one common to other bacterial lipoproteins. Using synthetic analogues of mycoplasmal
- CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection.
- Eur J Immunol. 1998 Dec;28(12):4213-20. Unique Identifier : AIDSLINE MED/99077174
- Saha B; Chattopadhyay S; Germond R; Harlan DM; Perrin PJ; Immune Cell Biology Program, Naval Medical Research Institute,; Bethesda, USA. root@nccs.ernet.in
- Since both the nature and the amplitude of an antigen-specific T cell response are dependent on co-stimulatory signals, we have investigated the role of CD28/CD152-mediated T cell co-stimulation in the regulation of experimental cutaneous leishmaniasis. CD28-deficient mice and their wild-type littermates are equally s
- T cell selection during the evolution of CD8+ T cell memory in vivo.
- Eur J Immunol. 1998 Dec;28(12):4382-90. Unique Identifier : AIDSLINE MED/99077191
- Callan MF; Annels N; Steven N; Tan L; Wilson J; McMichael AJ; Rickinson AB; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford,; GB. mcallan@molbiol.ox.ac.uk
- Memory T cell responses are frequently highly restricted in terms of receptor usage. How and when such clonotypic dominance is established remains poorly understood. Here we have investigated the evolution of the T cell responses to an epitope from Epstein-Barr virus (EBV), (FLRGRAYGL), by analyzing TCR use of clones
- Granulocyte colony-stimulating factor (G-CSF) may stimulate HIV-replication during cytostatic chemotherapy [letter]
- Eur J Haematol. 1998 Nov;61(5):354-5. Unique Identifier : AIDSLINE MED/99070894
- Weiner SM; Rump JA; Kreise W; Thimme R; Blum HE; Meyerhans A; Schneider J
- Role of T-helper type 2 cytokines in down-modulation of fas mRNA and receptor on the surface of activated CD4(+) T cells: molecular basis for the persistence of the allergic immune response.
- FASEB J. 1998 Dec;12(15):1747-53. Unique Identifier : AIDSLINE MED/99057839
- Spinozzi F; Agea E; Fizzotti M; Bassotti G; Russano A; Droetto S; Bistoni O; Grignani F; Bertotto A; Laboratory of Allergology and Clinical Immunology, Department of; Clinical and Experimental Medicine, Perugia, Italy.; spinozzi@unipg.it
- The mechanisms responsible for persistence of T lymphocytes at the sites of allergic inflammation are not completely understood. Activated T cells, usually expressing Fas on their surface, undergo activation-induced apoptotic death, thus limiting the dangerous consequences of a persistent immune reaction. We have prev
- HIV enteropathy: comparative morphometry of the jejunal mucosa of HIV infected patients resident in the United Kingdom and Uganda.
- Gut. 1998 Sep;43(3):350-5. Unique Identifier : AIDSLINE MED/99080848
- Batman PA; Kapembwa MS; Miller AR; Sedgwick PM; Lucas S; Sewankambo NK; Serwadda D; Pudney J; Moody A; Harris JR; Griffin GE; Bradford Royal Infirmary, UK.
- AIMS: To compare jejunal mucosal morphometry in HIV infected patients resident in London and Uganda . PATIENTS: Twenty HIV positive patients from London and 16 from Uganda were studied, and compared with HIV negative control subjects from both sites. METHODS: Stools and biopsy speci
- Gastric involvement in AIDS associated cryptosporidiosis.
- Gut. 1998 Oct;43(4):476-7. Unique Identifier : AIDSLINE MED/99071217
- Rossi P; Rivasi F; Codeluppi M; Catania A; Tamburrini A; Righi E; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.
- BACKGROUND: Cryptosporidiosis has been shown to be a common cause of diarrhoea in both immunocompetent and immunosuppressed individuals. There are very few data on the distribution of Cryptosporidium parvum along the gastrointestinal tract. AIMS: To evaluate the location of Cryptosporidium parasites in the digestive t
- Increased state of activation of CD4 positive T cells and elevated interferon gamma production in pouchitis.
- Gut. 1998 Oct;43(4):499-505. Unique Identifier : AIDSLINE MED/99071222
- Stallmach A; Schafer F; Hoffmann S; Weber S; Muller-Molaian I; Schneider T; Kohne G; Ecker KW; Feifel G; Zeitz M; Department of Internal Medicine II, University of Saarland,; Homburg, Germany.
- BACKGROUND: Immunoregulatory abnormalities of T cells might be of importance in the pathogenesis of pouchitis after ileoanal pouch anastomosis (IAP). AIMS: To characterise T cell subsets, their state of activation, and production of cytokines in inflamed and non-inflamed pouches in patients with ulcerative colitis (UC
- Pancreatic dysfunction and its association with fat malabsorption in HIV infected children.
- Gut. 1998 Oct;43(4):558-63. Unique Identifier : AIDSLINE MED/99071231
- Carroccio A; Fontana M; Spagnuolo MI; Zuin G; Montalto G; Canani RB; Verghi F; Di Martino D; Bastoni K; Buffardi F; Guarino A; Department of Internal Medicine, University of Palermo, Palermo,; Italy.
- BACKGROUND: Nutrient malabsorption frequently occurs in HIV infected children, but very few studies have investigated exocrine pancreatic digestive capacity in these cases. AIMS: To investigate pancreatic function in HIV infected children and to determine whether faecal fat loss, a prominent feature of intestinal dysf
- Assessment of archived paraffin-embedded cervical condyloma tissues for mycoplasma-conserved DNA using sensitive PCR-ELISA.
- Unique Identifier : AIDSLINE MED/99045532
- Kidder M; Chan PJ; Seraj IM; Patton WC; King A
- Clinically, it is important to detect mycoplasmas because these organisms have been implicated in gastric and ovarian cancer, pneumonia, postabortal fever, pelvic inflammatory disease, pyelonephritis, endometritis, urethritis, perinatal mortality, arthritis, spontaneous abortion, infertility and interference with sper
- Chronic chorioamnionitis: a clinicopathologic and immunohistochemical study.
- Hum Pathol. 1998 Dec;29(12):1457-61. Unique Identifier : AIDSLINE MED/99081431
- Jacques SM; Qureshi F; Department of Pathology, Hutzel Hospital and Wayne State; University School of Medicine, Detroit, MI 48201, USA.
- Lymphocytic inflammation of the fetal membranes is unusual and has been termed chronic chorioamnionitis. We report the clinicopathologic and immunohistochemical findings in 31 placentas with chronic chorioamnionitis. The most common histopathologic association was chronic villitis of unknown etiology, which was identi
- Maternal scleroderma: placental findings and perinatal outcome.
- Hum Pathol. 1998 Dec;29(12):1524-30. Unique Identifier : AIDSLINE MED/99081440
- Doss BJ; Jacques SM; Mayes MD; Qureshi F; Department of Pathology, Hutzel Hospital, Detroit Medical Center,; and Wayne State University School of Medicine, MI, USA.
- Pregnancy after the onset of scleroderma is uncommon; therefore, placental findings and perinatal outcome have rarely been correlated. The histopathologic features of placentas from 13 pregnancies in eight women with scleroderma were recorded and correlated with the clinical features of the mother and fetus. Adverse p
- Expression of proliferation and apoptosis-related proteins in usual ductal hyperplasia of the breast.
- Hum Pathol. 1998 Dec;29(12):1539-45. Unique Identifier : AIDSLINE MED/99081443
- Mommers EC; van Diest PJ; Leonhart AM; Meijer CJ; Baak JP; Department of Pathology, Free University Hospital, Amsterdam, The; Netherlands.
- Expression of proliferation- and apoptosis-related proteins was studied by immunohistochemistry in 130 usual ductal hyperplasias of the breast, of which 39 cases (30%) had adjacent invasive cancer. Overexpression of cyclin D1 and Ki-67 was found in 6% and 29% of the cases, respectively. Only two mild ductal hyperplasi
- Establishment of monoclonal antibody, gp21-34, against HTLV-II envelope protein (p20E).
- Hybridoma. 1998 Aug;17(4):347-54. Unique Identifier : AIDSLINE MED/99004729
- Miyagawa E; Yoshiki A; Fujii N; Honda H; Ueno E; Kurano Y; Ito S; Ube Research Laboratory, Fujirebio, Inc., Yoshiwa Ube, Yamaguchi,; Japan.
- A monoclonal antibody (MAb), gp21-34, specifically reactive with human T-lymphotropic virus type-II (HTLV-II) transmembranous envelope glycoprotein (p20E) was developed by immunization with a recombinant protein fused with thioredoxin moiety at the N-terminal portion. This MAb, which belongs to the IgG1 kappa subclass
- Four days at an AIDS hospice.
- Imprint. 1998 Nov-Dec;45(5):55-6. Unique Identifier : AIDSLINE MED/99066086
- Benoit M; Kennesaw State University School of Nursing, Kennesaw, Georgia,; USA.
- Mannose-binding lectin (MBL) in health and disease.
- Immunobiology. 1998 Aug;199(2):327-39. Unique Identifier : AIDSLINE MED/98450591
- Turner MW; Immunobiology Unit, Institute of Child Health, London, UK.; m.turner@ich.ucl.ac.uk
- Mannose-binding lectin (MBL) is the most intensively studied human collectin. It is recognized to be a versatile macro-molecule with many of the functional characteristics of IgM, IgG and Clq. In the presence of calcium the protein can bind to a wide spectrum of oligosaccharides through multiple lectin domains. Such b
- Incidence of HIV risk and prevention of infection in health care settings.
- Indian J Med Sci. 1998 Jun;52(6):239-43. Unique Identifier : AIDSLINE MED/99065882
- Ram S; Khurana S; Khurana SB; Dayanand Medical College & Hospital, Ludhiana.
- Tht HIV epidemic has created awareness about blood borne pathogens transmission in health care settings. Although, the risk of transmission of HIV and other blood borne pathogen may account for a very small proportion, yet the potential for such transmission always exists. Despite this, the use of proper and careful s
- Truck crew and risk of contraction of STDS, including HIV: encouraging the use of condoms by the method of applying theories.
- Indian J Med Sci. 1998 Jun;52(6):253-64. Unique Identifier : AIDSLINE MED/99065885
- Bansal RK; Nia AB; Department of Community Medicine, P.S. Medical College, Karamsad,; India.
- Studies from India conclude that the long distance truck crew are at a high risk of contracting and transmitting STDs and HIV on account of their high risk sexual behaviours. These studies indicate the necessity of changing the behaviour of the truck crew in favour of safer sexual p
- AIDS: knowledge and attitudes of university students in Nagpur.
- Indian J Med Sci. 1998 Jul;52(7):302-8. Unique Identifier : AIDSLINE MED/99063940
- Deshmukh JS; Wadhva SK; Zodpey SP; Dept of Preventive and Social Medicine, Govt. Medical College and; Hospital, Nagpur.
- The present cross section-I study was conducted on university students to assess the basic level of knowledge regarding AIDS. Mean score obtained by the Science students related to various aspects of AIDS was significantly higher as compared to Arts and Commerce students 94.4% Science students and 86.7%. Arts and Comm
- Inhibitory effect of biphalin and AZT on murine Friend leukemia virus infection in vitro.
- Int J Immunopharmacol. 1998 Sep;20(9):457-66. Unique Identifier : AIDSLINE MED/99034099
- Tang JL; Lipkowski AW; Specter S; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa 33612, USA.
- Biphalin is a bivalent opioid analogue containing two tyrosine residues. We have examined the effect of biphalin s anti-retroviral potency in vitro using a murine model. Biphalin, in non-cytotoxic concentrations, suppressed in a dose-dependent fashion the replication of Friend leukemia virus (FLV) in Mus dunni cells a
- [Clinical studies on the use of protease inhibitors in HIV infection. Answers and questions]
- Internist (Berl). 1998 Sep;39(9):927-34. Unique Identifier : AIDSLINE MED/99004382
- Fatkenheuer G; Salzberger B; Franzen C; Diehl V; Klinik I fur Innere Medizin, Universitat zu Koln.
- From silencing the self to action: experiences of women living with HIV/AIDS.
- Health Care Women Int. 1998 Nov-Dec;19(6):539-52. Unique Identifier : AIDSLINE MED/99066061
- DeMarco RF; Miller KH; Patsdaughter CA; Chisholm M; Grindel CG; Northeastern University, College of Nursing, Boston, MA 02115,; USA. rdemarco@lynx.neu.edu
- Feminist literature has demonstrated that women often maintain behaviors that support silencing of their voices. The critical issue is whether the silencing experience is (a) a destructive process of burying feelings and needs, (b) a protective strategy to preserve personal and professional relationships which they va
- A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors.
- J Clin Invest. 1998 Nov 15;102(10):1769-75. Unique Identifier : AIDSLINE MED/99038179
- Winters MA; Coolley KL; Girard YA; Levee DJ; Hamdan H; Shafer RW; Katzenstein DA; Merigan TC; Center for AIDS Research at Stanford, Stanford University,; Stanford, California 94305-5107, USA. winters@stanford.edu
- While many point mutations in the HIV-1 reverse transcriptase (RT) confer resistance to antiretroviral drugs, inserts or deletions in this gene have not been previously characterized. In this report, 14 RT inhibitor-treated patients were found to have HIV-1 strains possessing a 6-basepair insert between codons 69 and
- Further confirmation of the association of human herpesvirus 8 with Kaposi's sarcoma.
- J Cutan Pathol. 1998 Sep;25(8):413-9. Unique Identifier : AIDSLINE MED/99041539
- Li N; Anderson WK; Bhawan J; Department of Dermatology, Boston University School of Medicine,; Massachusetts, USA.
- Recently, a new herpesvirus-like DNA sequence named Kaposi s sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) has been isolated from almost all cases of Kaposi s sarcoma (KS). It has not been found in most benign and malignant cutaneous hemangioproliferative disorders other than KS. To further verif
- Primary epidural non-Hodgkin's lymphoma with cervical location in an HIV-negative child: case report.
- J Child Neurol. 1998 Oct;13(10):520-2. Unique Identifier : AIDSLINE MED/99010785
- Koseoglu V; Kurekci AE; Akin R; Gunhan O; Ucoz T; Ozcan O; Gokcay E; Department of Pediatric Oncology, Gulhane Military Medical; Academy and Medical School, Ankara, Turkey.
- The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss.
- J Hepatol. 1998 Oct;29(4):669-75. Unique Identifier : AIDSLINE MED/99039884
- de Man RA; Bartholomeusz AI; Niesters HG; Zondervan PE; Locarnini SA; Department of Hepatogastroenterology, Erasmus University; Hospital, Rotterdam, The Netherlands. MAN@INW2.AZR.NL
- BACKGROUND/AIMS: The purpose of this study was to characterize the clinical, histological and virological events in an orthotopic liver transplant (OLT) recipient with recurrent hepatitis B infection who was initially managed with hepatitis B immune globulin (HBIg) and when viral recurrence occurred, with nucleoside a
- A novel method for concurrent visualization of immunostain under light and electron microscopy in pancreatic islets.
- Unique Identifier : AIDSLINE MED/99034621
- Wong FS
- Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets.
- J Invest Dermatol. 1998 Dec;111(6):1072-8. Unique Identifier : AIDSLINE MED/99072639
- Szabo SK; Hammerberg C; Yoshida Y; Bata-Csorgo Z; Cooper KD; Department of Dermatology, Case Western Reserve University,; University Hospitals of Cleveland, Ohio 44106, USA.
- Interferon-gamma (IFN-gamma) produced by lesional T cell clones is critical for the induction into G1 of the cell cycle by psoriatic keratinocyte stem cells; however, direct data demonstrating psoriatic lesional T cell subset IFN-gamma expression, and quantitation at a single cell level to calculate in vivo proportion
- Increased type 2 cytokine expression by both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis.
- J Invest Dermatol. 1998 Dec;111(6):1079-84. Unique Identifier : AIDSLINE MED/99072640
- Sato A; Tsuji K; Yamamura M; Morita Y; Kanzaki H; Tada J; Makino H; Arata J; Department of Dermatology, Okayama University Medical School,; Japan.
- Type 2 cytokines, such as interleukin-4 (IL-4) and IL-13, are associated with immunoglobulin E (IgE) production. This association has also been observed in CD8+ T cells from patients infected with leprosy and human immunodeficiency virus (HIV). Using intracellular cytokine staining and flow cytometry, the cytokine pro
- Wound fluid from venous leg ulcers degrades plasminogen and reduces plasmin generation by keratinocytes.
- J Invest Dermatol. 1998 Dec;111(6):1140-4. Unique Identifier : AIDSLINE MED/99072650
- Hoffman R; Starkey S; Coad J; European Institute of Health and Medical Sciences, University of; Surrey, Guildford, UK.
- Plasminogen, the pro-enzyme of plasmin, aids various processes essential for normal, acute wound healing, such as fibrinolysis and cell migration. We have investigated if plasminogen is available to perform these functions in chronic wounds such as venous leg ulcers. We report that plasminogen is degraded by fluid fro
- Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes.
- J Invest Dermatol. 1998 Dec;111(6):996-1002. Unique Identifier : AIDSLINE MED/99072627
- Wingens M; van Bergen BH; Hiemstra PS; Meis JF; van Vlijmen-Willems IM; Zeeuwen PL; Mulder J; Kramps HA; van Ruissen F; Schalkwijk J; Department of Dermatology, University Hospital Nijmegen, The; Netherlands.
- Secretory leukocyte protease inhibitor (SLPI) is a small, cationic protein that is known to be constitutively expressed by several glandular epithelia. SLPI inhibits leukocyte-derived proteinases, has anti-HIV-1, antibacterial, and anti-fungal properties, and interferes with the induction of synthesis of proinflammato
- Detection of human herpesvirus 8 DNA sequences in tissues and bodily fluids.
- J Infect Dis. 1998 Dec;178(6):1610-5. Unique Identifier : AIDSLINE MED/99034644
- LaDuca JR; Love JL; Abbott LZ; Dube S; Freidman-Kien AE; Poiesz BJ; Division of Hematology and Oncology, Department of Internal; Medicine, SUNY Health Science Center, Syracuse, NY 13210, USA.
- Human herpesvirus 8 (HHV-8) has been proposed as a sexually transmitted etiologic agent of Kaposi s sarcoma (KS). In this study, by use of a sensitive polymerase chain reaction assay, HHV-8 DNA was detected in the skin lesions (92%), normal skin (23%), peripheral blood mononuclear cells (PBMC) (46%), plasma (7%), sali
- Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men.
- J Infect Dis. 1998 Dec;178(6):1616-22. Unique Identifier : AIDSLINE MED/99034645
- Schacker T; Zeh J; Hu HL; Hill E; Corey L; Department of Medicine, University of Minnesota, Minneapolis, MN; 55455, USA. schac008@Linti.med.umn.edu
- Herpes simplex virus (HSV) infection is common in persons coinfected with human immunodeficiency virus (HIV). In a prospective study, daily viral cultures of the mouth, genitals, and rectum were collected from 68 HIV-positive and 13 HIV-negative men who have sex with men. Subjects completed a median of 57 days of foll
- Chemokine receptors and the molecular basis for human immunodeficiency virus type 1 entry into peripheral hematopoietic stem cells and their progeny.
- J Infect Dis. 1998 Dec;178(6):1623-34. Unique Identifier : AIDSLINE MED/99034646
- Zhao SF; Li W; Dornadula G; Dicker D; Hoxie J; Peiper SC; Pomerantz RJ; Duan LX; Dorrance H Hamilton Laboratories, Center for Human Virology,; Department of Medicine, Division of Infectious Diseases,; Philadelphia, PA 19107-6799, USA.
- There exist at least two major coreceptors for human immunodeficiency virus (HIV)-1 entry into target cells, the CXCR-4 and CCR-5 chemokine receptors for T lymphocyte-tropic and macrophage-tropic strains of HIV-1, respectively. Highly purified human CD34 cells derived from umbilical cord blood were shown not to expres
- Human submandibular saliva inhibits human immunodeficiency virus type 1 infection by displacing envelope glycoprotein gp120 from the virus.
- J Infect Dis. 1998 Dec;178(6):1635-41. Unique Identifier : AIDSLINE MED/99034647
- Nagashunmugam T; Malamud D; Davis C; Abrams WR; Friedman HM; Division of Infectious Diseases, Department of Medicine,; University of Pennsylvania, Philadelphia, PA 19104-6073, USA.; tnagi@mail.med.upenn.edu
- Human submandibular saliva reduces human immunodeficiency virus type 1 (HIV-1) infection in vitro. To define the mechanism of inhibition, virus was incubated with saliva or medium, velocity sucrose gradient centrifugation was performed, and fractions were analyzed for p24 and gp120. The results show that after incubat
- The effect of acute infectious illnesses on plasma human immunodeficiency virus (HIV) type 1 load and the expression of serologic markers of immune activation among HIV-infected adults.
- J Infect Dis. 1998 Dec;178(6):1642-8. Unique Identifier : AIDSLINE MED/99034648
- Sulkowski MS; Chaisson RE; Karp CL; Moore RD; Margolick JB; Quinn TC; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore, MD, USA.
- The effect of acute coinfections on plasma human immunodeficiency virus (HIV) load and immune activation markers was evaluated. Thirty-two HIV-infected persons were prospectively enrolled; 18 had pre-illness, acute, and follow-up specimens. Plasma HIV RNA levels were determined by reverse transcriptase-polymerase chai
- The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects.
- J Infect Dis. 1998 Dec;178(6):1688-97. Unique Identifier : AIDSLINE MED/99034654
- Palmer KL; Schnizlein-Bick CT; Orazi A; John K; Chen CY; Hood AF; Spinola SM; Departments of Medicine, Microbiology, and Immunology, Indiana; University, Indianapolis, IN 46202, USA.
- Previous work in 3 subjects infected for 2 weeks indicated that experimental infection with Haemophilus ducreyi recruits CD4 cells to the skin at the pustular stage of disease. In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H. ducreyi. Subjects
- Serial isolates of Cryptococcus neoformans from patients with AIDS differ in virulence for mice.
- J Infect Dis. 1998 Dec;178(6):1761-6. Unique Identifier : AIDSLINE MED/99034663
- Fries BC; Casadevall A; Department of Medicine, Division of Infectious Disease,; Montefiore Medical Center, Albert Einstein College of Medicine,; Bronx, NY 10461, USA.
- Serial isolates of Cryptococcus neoformans from patients with chronic infection can exhibit minor karyotype changes as a result of chromosome length polymorphism (CLP). This study investigated whether serial C. neoformans isolates with CLP from 4 patients with AIDS exhibited biologic and phenotypic differences. CLP pe
- Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS.
- J Infect Dis. 1998 Dec;178(6):1787-90. Unique Identifier : AIDSLINE MED/99034668
- He J; Bhat G; Kankasa C; Chintu C; Mitchell C; Duan W; Wood C; School of Biological Sciences, University of Nebraska, Lincoln,; Nebraska, 68588-0666
- The seroprevalence of human herpesvirus 8 (HHV-8) among a group of Zambian women of reproductive age and among mother-child pairs in which either one of them has Kaposi s sarcoma (KS) was determined. A cross-sectional group of 378 pregnant women was randomly recruited into the study, and 183 (48.4%) had HHV-8 antibodi
- Serologic and molecular evidence of human herpesvirus 8 activation in renal transplant recipients.
- J Infect Dis. 1998 Dec;178(6):1791-4. Unique Identifier : AIDSLINE MED/99034669
- Hudnall SD; Rady PL; Tyring SK; Fish JC; Departments of Pathology, Microbiology, and Surgery, University; of Texas Medical Branch, Galvaston, TX 77555-0741, USA.
- This study was designed to determine whether there is serologic or molecular evidence of human herpesvirus 8 (HHV-8) activation in renal transplant patients, an immunocompromised population at risk for development of Kaposi s sarcoma. Indirect immunofluorescence for detection of HHV-8 serum antibody and Southern blot
- Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities. The Genital Ulcer Disease Surveillance Group.
- J Infect Dis. 1998 Dec;178(6):1795-8. Unique Identifier : AIDSLINE MED/99034670
- Mertz KJ; Trees D; Levine WC; Lewis JS; Litchfield B; Pettus KS; Morse SA; St Louis ME; Weiss JB; Schwebke J; Dickes J; Kee R; Reynolds J; Hutcheson D; Green D; Dyer I; Richwald GA; Novotny J; Weisfuse I; Goldberg M; O'Donnell JA; Knaup R; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- To determine the etiology of genital ulcers and to assess the prevalence of human immunodeficiency virus (HIV) infection in ulcer patients in 10 US cities, ulcer and serum specimens were collected from approximately 50 ulcer patients at a sexually transmitted disease clinic in each city. Ulcer specimens were tested us
- Major histocompatibility complex genotype is associated with disease progression and virus load levels in a cohort of human immunodeficiency virus type 1-infected Caucasians and African Americans.
- Unique Identifier : AIDSLINE MED/99034671
- Mann DL; Garner RP; Dayhoff DE; Cao K; Fernandez-Vina MA; Davis C; Aronson N; Ruiz N; Birx DL; Michael NL; Immunogenetics Division, Department of Pathology, University of; Maryland Medical System, Baltimore, MD 21201, USA.; dmann001@umaryland.edu
- To assess the influence of HLA on AIDS-free survival, human immunodeficiency virus load, and CD4 cell counts, 91 Caucasian and 48 African-American seroprevalent men were typed for HLA classes I and II and TAP alleles. HLA associations with these markers were assessed by assigning sum integer scores based on 7 class I
- Variability in repeated consecutive measurements of plasma human immunodeficiency virus RNA in persons receiving stable nucleoside reverse transcriptase inhibitor therapy or no treatment.
- J Infect Dis. 1998 Dec;178(6):1803-5. Unique Identifier : AIDSLINE MED/99034672
- Bartlett JA; DeMasi R; Dawson D; Hill A; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA. jab5@acpub.duke.edu
- Plasma human immunodeficiency virus (HIV) RNA levels correlate closely with clinical prognosis in both treated and untreated HIV-infected persons and are widely used to guide clinical practice and as a primary end point in clinical trials. Thus, variability in these measurements may significantly affect their interpre
- Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants.
- J Infect Dis. 1998 Dec;178(6):1806-11. Unique Identifier : AIDSLINE MED/99034673
- van Rij RP; de Roda Husman AM; Brouwer M; Goudsmit J; Coutinho RA; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands, Amsterdam, The Netherlands.
- The effect of a valine to isoleucine switch in the CCR2 first transmembrane domain (CCR2 64I) on the clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed in relation to the presence or absence of syncytium-inducing (SI) HIV-1 variants. Compared with persons with a wild-type genotype fo
- Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection. The Sydney Primary HIV Infection Study Group.
- J Infect Dis. 1998 Dec;178(6):1812-5. Unique Identifier : AIDSLINE MED/99034674
- Kaufmann GR; Cunningham P; Kelleher AD; Zaunders J; Carr A; Vizzard J; Law M; Cooper DA; Centre for Immunology and HIV Medicine Unit, St Vincent's; Hospital, and National Centre in HIV Epidemiology and Clinical; Research, Sydney, Australia.
- This study used curve-fitting techniques to detail the dynamics of human immunodeficiency virus (HIV)-1 and its relationship to circulating T lymphocyte changes in a cohort of 41 male patients (mean age 36+/-7 years) infected with HIV-1. The following characteristics of viral kinetics were obtained: virus load peak, 6
- Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.
- J Infect Dis. 1998 Dec;178(6):1816-20. Unique Identifier : AIDSLINE MED/99034675
- Taoufik Y; Gasnault J; Karaterki A; Pierre Ferey M; Marchadier E; Goujard C; Lannuzel A; Delfraissy JF; Dussaix E; Department of Microbiology, Paul Brousse Hosptial, Cedex, France.; yassine.taoufik@pbr.ap-hop-paris.fr
- JC virus (JCV) load was determined by using quantitative polymerase chain reaction in cerebrospinal fluid (CSF) of 12 patients with AIDS-associated progressive multifocal leukoencephalopathy (PML) and compared with clinical outcome. JCV loads varied widely (3-7 log10 JCV equivalents/mL of CSF) and were apparently not
- Unresponsive CD4+ T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1/CTLA-4 molecular pathway.
- J Infect Dis. 1998 Dec;178(6):1847-51. Unique Identifier : AIDSLINE MED/99034682
- Gomes NA; Barreto-de-Souza V; Wilson ME; DosReis GA; Immunobiology Program, Instituto de Biofisica Carlos Chagas; Filho, Universidade Federal do Rio de Jameiro, Brazil.
- Infection of BALB/c mice with Leishmania chagasi results in progressive increase of parasite burden in spleen, in spite of extensive T cell activation in situ. Explanted splenic CD4+ T cells showed decreased proliferation to anti-CD3, compared with controls, and no response to L. chagasi recombinant antigen Lcr1. Bloc
- Interferon-gamma and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis.
- J Infect Dis. 1998 Dec;178(6):1856-9. Unique Identifier : AIDSLINE MED/99034684
- Neva FA; Filho JO; Gam AA; Thompson R; Freitas V; Melo A; Carvalho EM; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892-0425, USA.
- Possible immunologic interaction between infection with human T lymphotropic virus type 1 (HTLV-1), a retrovirus, and the intestinal parasite Strongyloides stercoralis was investigated in persons infected with one or both agents. This was done by examining the cytokine responses of peripheral blood mononuclear cells (
- Pentoxifylline in human immunodeficiency virus- positive tuberculosis: safety at 4 years [letter]
- J Infect Dis. 1998 Dec;178(6):1861. Unique Identifier : AIDSLINE MED/99034686
- Wallis RS; Johnson JL; Okwera A; Nsubuga P; Whalen CC; Mugerwa RD; Ellner JJ
- Burkitt-like lymphomas in AIDS patients: characterization within a series of 103 human immunodeficiency virus-associated non-Hodgkin's lymphomas. Burkitt's Lymphoma Study Group.
- J Clin Oncol. 1998 Dec;16(12):3788-95. Unique Identifier : AIDSLINE MED/99065275
- Davi F; Delecluse HJ; Guiet P; Gabarre J; Fayon A; Gentilhomme O; Felman P; Bayle C; Berger F; Audouin J; Bryon PA; Diebold J; Raphael M; Departement d'Hematologie and Unite Recherche Associee du; Centre National de la Recherche Scientifique 625, Hopital; Pitie-Salpetriere, Paris, France. fdavi@pasteur.fr
- PURPOSE: Burkitt-like lymphoma (BLL) is a tumor with morphologic features intermediate between Burkitt s lymphoma (BL) and large-cell lymphoma, but its relationship with these lymphomas is currently unclear. We have therefore analyzed its characteristics within a large series of human immunodeficiency virus (HIV)-asso
- Editors' introduction: HIV/AIDS interventions for out-of-treatment drug users.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):225-9. Unique Identifier : AIDSLINE MED/99013131
- Inciardi JA; Needle RH; Center for Drug and Alcohol Studies, Department of Sociology and; Criminal Justice, University of Delaware, USA.
- Theoretical models used to guide NIDA's cooperative agreement research and intervention efforts. National Institute on Drug Abuse.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):231-8. Unique Identifier : AIDSLINE MED/99013132
- Stevens SJ; Kotranski L; Williams M; Bowen AE; McCoy HV; Southwest Institute for Research on Women, University of Arizona,; Tucson 85714, USA.
- NIDA s Cooperative Agreement program to reach out-of-treatment drug users and provide HIV prevention to reduce HIV drug and sexual risks was initiated in September of 1990. By August, 1994 the program included 23 sites which used various theoretical models to guide prevention strategies, add conceptual coherence to ma
- HIV serostatus and risk behaviors in a multisite sample of drug users.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):239-45. Unique Identifier : AIDSLINE MED/99013133
- Deren S; Beardsley M; Coyle S; Singer M; Center for Drug Use and HIV Research and the Institute for AIDS; Research, National Development and Research Institutes, New York,; New York 10048, USA.
- In developing HIV prevention efforts, it is critical to determine whether interventions are effective in achieving declines in risk behavior among both HIV-positive and HIV-negative individuals. Based on a multisite intervention study of injection drug users (IDUs) and crack smokers, 488 seropositive IDUs and 364 sero
- Drug use and HIV risks among African-American, Mexican-American, and Puerto Rican drug injectors.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):247-53. Unique Identifier : AIDSLINE MED/99013134
- Estrada AL; Mexican-American Studies and Research Center, University of; Arizona, Tucson 85721-0023, USA.
- This article documents the prevalence of injection-related HIV risk behaviors among a sample of 758 Mexican-American, Puerto Rican, and African-American drug injectors derived from the National Institute on Drug Abuse Cooperative Agreement database. The results show that the two Hispanic subgroups had higher injection
- Unraveling the concept of race in Brazil: issues for the Rio de Janeiro Cooperative Agreement site.
- Unique Identifier : AIDSLINE MED/99013135
- Surratt HL; Inciardi JA
- Scholars throughout the Americas have spent much of the 20th century studying race and its meaning in Brazil . Racial identities in Brazil are dynamic concepts which can only be understood if situated and explored within the appropriate
- Efficacy and effectiveness issues in the NIDA Cooperative Agreement: interventions for out-of-treatment drug users. National Institute on Drug Abuse.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):261-8. Unique Identifier : AIDSLINE MED/99013136
- Rhodes F; Wood MM; Booth RE; Center for Behavioral Research and Services, California State; University, Long Beach 90813, USA. frhodes@csulb.edu
- This paper examines the Cooperative Agreement (CA) HIV intervention studies for active drug users, sponsored by the National Institute on Drug Abuse, in terms of the constructs of prevention efficacy and effectiveness. A rationale is presented for conservatively interpreting outcome findings of these studies as indica
- Effectiveness of HIV/AIDS interventions on drug use and needle risk behaviors for out-of-treatment injection drug users.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):269-78. Unique Identifier : AIDSLINE MED/99013137
- Booth RE; Kwiatkowski CF; Stephens RC; Department of Psychiatry, University of Colorado Health Sciences; Center, Denver, USA.
- Abstract-This study presents an evaluation of the effectiveness of the AIDS Community-Based Outreach/Intervention projects implemented as part of the National Institute on Drug Abuse (NIDA) Cooperative Agreement (CA), which began in 1990 and is currently ongoing. Participants in the CA were randomly assigned to one of
- Effectiveness of HIV risk reduction initiatives among out-of-treatment non-injection drug users.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):279-90. Unique Identifier : AIDSLINE MED/99013138
- Cottler LB; Leukefeld C; Hoffman J; Desmond D; Wechsberg W; Inciardi JA; Compton WM; Ben Abdallah A; Cunningham-Williams R; Woodson S; Department of Psychiatry, Washington University School of; Medicine, St. Louis, Missouri 63108, USA.
- While attention has been paid recently to the effectiveness of HIV/AIDS interventions among injection drug users, less focus has been given to out-of-treatment noninjecting drug users. This study examines the the NIDA Cooperative Agreement standard intervention versus an enhanced intervention for HIV/AIDS risk among n
- HIV prevention protocols: adaptation to evolving trends in drug use.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):291-8. Unique Identifier : AIDSLINE MED/99013139
- Wechsberg WM; Desmond D; Inciardi JA; Leukefeld CG; Cottler LB; Hoffman J; Substance Abuse Treatment Research Program, Health and Social; Policy Division, Research Triangle Institute, Research Triangle; Park, North Carolina 27709-2194, USA.
- Applied research in HIV prevention with out-of-treatment substance abusers takes place in a constantly changing environment. Researchers must be able to identify changes in drug use and sexual risk patterns, develop and evaluate appropriate interventions to respond to those changes, and find ways to make effective use
- Seroconversion issues among out-of-treatment injection drug users.
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):299-305. Unique Identifier : AIDSLINE MED/99013140
- Fisher DG; Fenaughty AM; Trubatch B; University of Alaska, Anchorage 99508, USA. afdgf@uaa.alaska.edu
- Many risk factors for HIV incidence among drug users have been reported in the literature. However most of these studies have been with local samples, and typically have had limited sample sizes. The National Institute on Drug Abuse (NIDA) funded a Cooperative Agreement for AIDS Community-Based Outreach/Intervention R
- Postscript: where do we go from here?
- J Psychoactive Drugs. 1998 Jul-Sep;30(3):307-14. Unique Identifier : AIDSLINE MED/99013141
- Sloboda Z; Stephens RC; Alemagno S; Division of Epidemiology and Prevention Research, National; Institute on Drug Abuse, Rockville, Maryland 20857, USA.
- Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.
- J Med Chem. 1998 Dec 3;41(25):4927-32. Unique Identifier : AIDSLINE MED/99055305
- Leydet A; Moullet C; Roque JP; Witvrouw M; Pannecouque C; Andrei G; Snoeck R; Neyts J; Schols D; De Clercq E; Laboratoire de Chimie Organique Physique, Universite Montpellier; II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
- New polyanionic compounds were obtained from radical addition of thiomalic acid and mercaptopropionic acid onto perallylated cyclodextrins (CDs) under UV irradiation with a catalytic amount of alpha,alpha -azobis(isobutyronitrile). All these polyanions, bearing 18-48 carboxylate groups, inhibited human immunodeficienc
- Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines.
- J Med Chem. 1998 Dec 3;41(25):4958-64. Unique Identifier : AIDSLINE MED/99055309
- Tutonda MG; Buckheit RW Jr; Agrawal VK; Broom AD; Department of Medicinal Chemistry, 20 South 2030 East, 295; Biomedical Polymers Research Building, University of Utah, Salt; Lake City, Utah 84112-9453, USA.
- Several amphipathic (hydrophobic base, hydrophilic backbone) polyribonucleotides have recently been shown to have potent antiviral activity against HIV and human cytomegalovirus (HCMV). The working hypothesis developed during these studies was that the ability to form an ordered, n
- Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.
- J Med Chem. 1998 Dec 3;41(25):5113-7. Unique Identifier : AIDSLINE MED/99055323
- Kaltenbach RF 3rd; Nugiel DA; Lam PYS; Klabe RM; Seitz SP; DuPont Merck Pharmaceutical Company, P.O. Box 80500, Wilmington,; Delaware 19880-0500, USA.
- We have synthesized stereoisomers of cyclic urea HIV-1 protease inhibitors to study the effect of varying configurations on binding affinities. Four different synthetic approaches were used to prepare the desired cyclic urea stereoisomers. The original cyclic urea s
- The AIDS Net: HIV/AIDS resources on the World Wide Web.
- JAMA. 1998 Dec 16;280(23):2037-8. Unique Identifier : AIDSLINE MED/99079563
- Peters R; Sikorski R; Mednav.com, Inc, Byfield, Mass, USA. mail@mednav.com
- [Successful treatment of an HB carrier developing severe hepatitis using lamivudine--case report]
- Nippon Shokakibyo Gakkai Zasshi. 1998 Oct;95(10):1136-40. Unique Identifier : AIDSLINE MED/99022774
- Handa K; Inoue K; Sekiyama K; Yoshiba M; Fujita R; Takahashi Y; Division of Gastroenterology, Showa University Fujigaoka; Hospital.
- Comparison of health status, socioeconomic characteristics, and knowledge and use of HIV-related resources between HIV-infected women and men.
- Med Care. 1998 Dec;36(12):1676-84. Unique Identifier : AIDSLINE MED/99075399
- Davidson AJ; Bertram SL; Lezotte DC; Marine WM; Rietmeijer CA; Hagglund BB; Cohn DL; Department of Public Health, Denver Health and Hospitals,; University of Colorado Health Sciences Center, USA.
- OBJECTIVES: The authors compared socioeconomic characteristics, and knowledge and use of human immunodeficiency virus (HIV)-related resources and health status measures between HIV-infected women and men registered within the Denver Health and Hospitals health care system. METHODS: Data collected through two Centers f
- Tuberculosis: a search for novel therapy starting with natural products.
- Med Res Rev. 1998 Nov;18(6):363-74. Unique Identifier : AIDSLINE MED/99043739
- Mitscher LA; Baker W; Department of Medicinal Chemistry, Kansas University, Lawrence; 66047, USA. Lmitscher@Rx.pharm.ukans.edu
- The reemergence of tuberculosis and closely related diseases as significant public health problems is briefly reviewed with particular emphasis on the exacerbating role of AIDS and multiple drug resistance. Screening methods available for discovering new chemical entities active against resistant strains are discussed
- Should research ethics change at the border? [editorial; comment]
- Med J Aust. 1998 Nov 16;169(10):509-10. Unique Identifier : AIDSLINE MED/99078897
- McNeill PM
- Clinical trials in developing countries: scientific and ethical issues [see comments]
- Med J Aust. 1998 Nov 16;169(10):545-8. Unique Identifier : AIDSLINE MED/99078906
- Studdert DM; Brennan TA; Department of Health Policy and Management, Harvard School of; Public Health, Boston, MA, USA. studdert@rand.org
- Since the 1994 finding that intensive zidovudine treatment of mothers and infants can dramatically reduce perinatal transmission of human immunodeficiency virus, this treatment has been widely adopted in developed countries. In developing countries, trials of less-intensive (and cheaper) regimens have gone ahead, many
- Back to school. Alliance takes AIDS prevention message to middle schools.
- Minn Med. 1998 Oct;81(10):24-5. Unique Identifier : AIDSLINE MED/99015123
- Thistle J
- [Candida albicans: the relationship between morphotypes and in-vitro adhesivity to the oral mucosa cells of HIV-positive and AIDS patients. I]
- Minerva Stomatol. 1998 Sep;47(9):351-9. Unique Identifier : AIDSLINE MED/99052461
- Malighetti V; Arosio M; Bellotti MG; Spadari E; Zambellini Artini M; Spadari F; Riviera L; Istituto di Microbiologia Medica, Universita degli Studi,; Milano.
- BACKGROUND: The significant frequency of oropharyngeal candidiasis due to C. albicans in HIV-infected and AIDS patients and the undoubted differences in pathogenicity among strains, lead us to study whether a possible correlation exists between the phenotypic characteristics of the fungal strain and the blastospores a
- Staphylococcus aureus infections [letter]
- N Engl J Med. 1998 Dec 31;339(27):2026-7. Unique Identifier : AIDSLINE MED/99077415
- Tacconelli E; Tumbarello M; Cauda R
- Poxvirus dilemmas [letter]
- N Engl J Med. 1998 Dec 31;339(27):2027-8. Unique Identifier : AIDSLINE MED/99077416
- Hooper C
- Appearance of human herpesvirus 8 on electron microscopy [letter]
- N Engl J Med. 1999 Jan 7;340(1):62-4. Unique Identifier : AIDSLINE MED/99090888
- Orenstein JM; Herndier B
- US scientists may boycott AIDS congress [news]
- Nature. 1998 Dec 10;396(6711):504. Unique Identifier : AIDSLINE MED/99075318
- Cherry M
- [Microglia: mechanisms of activation and significance in pathogenesis of neuropsychiatric illnesses]
- Nervenarzt. 1998 Sep;69(9):752-62. Unique Identifier : AIDSLINE MED/99005695
- Gebicke-Haerter PJ; Lieb K; Illes P; Berger M; Psychiatrische Universitatsklinik, Universitat, Freiburg.
- Microglia are the resident macrophages of the brain. They are the central cellular element to initiate defense mechanisms against destructive environmental influences and to facilitate regenerative processes. No other cell type of the brain is endowed with a comparably comprehensive, immunocompetent machinery like mic
- The Th1-Th2 paradigm in 1998: law of nature or rule with exceptions [editorial]
- Nephrol Dial Transplant. 1998 Oct;13(10):2445-8. Unique Identifier : AIDSLINE MED/99008664
- Kunzendorf U; Tran TH; Bulfone-Paus S
- The antiproliferative effect of glucocorticoids: is it related to induction of TGF-beta? [editorial]
- Nephrol Dial Transplant. 1998 Oct;13(10):2450-2. Unique Identifier : AIDSLINE MED/99008666
- Almawi WY; Irani-Hakime N
- Kaposi's sarcoma after renal transplantation.
- Nephrol Dial Transplant. 1998 Nov;13(11):2768-73. Unique Identifier : AIDSLINE MED/99044942
- Frances C; Service de Medecine Interne, Hopital de la Pitie, Paris,; France.
- Cryptosporidiosis in a haemodialysis patient with depressed CD4+ T cell count: successful treatment with azithromycin.
- Nephrol Dial Transplant. 1998 Nov;13(11):2932-3. Unique Identifier : AIDSLINE MED/99044971
- Gascon A; Zabala S; Iglesias E; Service of Internal Medicine, General Hospital Obispo Polanco,; Teruel, Spain.
- Antigen-specific T-cell receptor V beta expression in Porphyromonas gingivalis-specific T-cell lines.
- Oral Microbiol Immunol. 1998 Dec;13(6):355-61. Unique Identifier : AIDSLINE MED/99089277
- Gemmell E; Grieco DA; Cullinan MP; Westerman B; Seymour GJ; Immunopathology Laboratory, School of Dentistry, University of; Queensland, Brisbane, Australia.
- FACS analysis was used to determine the expression of 15 T-cell receptor V beta families on CD4 and CD8 cells in Porphyromonas gingivalis specific T-cell lines established from eight P. gingivalis-positive adult periodontitis and seven P. gingivalis-positive healthy or gingivitis subjects. All 15 T-cell receptor V bet
- Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group.
- Pediatr Infect Dis J. 1998 Oct;17(10):872-80. Unique Identifier : AIDSLINE MED/99017627
- Mofenson LM; Yogev R; Korelitz J; Bethel J; Krasinski K; Moye J Jr; Nugent R; Rigau-Perez JG; Pediatric, Adolescent and Maternal AIDS Branch, Center for; Research for Mothers and Children, National Institute of Child; Health and Human Development, National Institutes of Health,; Rockville, MD 20852, USA. LM65D@nih.gov
- OBJECTIVE: To describe the epidemiologic, clinical, radiologic, laboratory and treatment characteristics of acute pneumonia and its association with mortality in HIV-infected children. METHODS: Data were collected during a trial of intravenous immunoglobulin (IVIG) for infection prophylaxis (1988 to 1991); CD4+ percen
- Spontaneous bleeding associated with the use of the protease inhibitor ritonavir in a hemophiliac patient with human immunodeficiency virus infection.
- Pediatr Infect Dis J. 1998 Oct;17(10):929-30. Unique Identifier : AIDSLINE MED/99017643
- Hagerty SL; Ascher DP; Department of Pediatrics, Wilford Hall Medical Center, Lackland; Air Force Base, San Antonio, TX 78236, USA.
- Varicella and zoster in children with human immunodeficiency virus infection.
- Pediatr Infect Dis J. 1998 Oct;17(10):931-3. Unique Identifier : AIDSLINE MED/99017645
- Derryck A; LaRussa P; Steinberg S; Capasso M; Pitt J; Gershon AA; Department of Pediatrics, Columbia University College of; Physicians and Surgeons, New York, NY, USA.
- RNA bulge entropies in the unbound state correlate with peptide binding strengths for HIV-1 and BIV TAR RNA because of improved conformational access.
- Nucleic Acids Res. 1998 Nov 15;26(22):5212-7. Unique Identifier : AIDSLINE MED/99030529
- Lustig B; Bahar I; Jernigan RL; Department of Chemistry, San Jose State University, San Jose, CA; 95192, USA. lustig@batnet.com
- For the binding of peptides to wild-type HIV-1 and BIV TAR RNA and to mutants with bulges of various sizes, changes in the DeltaDelta G values of binding were determined from experimental K d values. The corresponding entropies of these bulges are estimated by enumerating all possible RNA bulge conformations on a latt
- Sir David Cuthbertson Prize Medal Lecture. Metabolic abnormalities and wasting in human immunodeficiency virus infection.
- Proc Nutr Soc. 1998 Aug;57(3):373-80. Unique Identifier : AIDSLINE MED/99010408
- Macallan DC; Division of Infectious Diseases, St George's Hospital Medical; School, London, UK. macallan@sghms.ac.uk
- Sexualization of the female foot as a response to sexually transmitted epidemics: a preliminary study.
- Psychol Rep. 1998 Oct;83(2):491-8. Unique Identifier : AIDSLINE MED/99037359
- Giannini AJ; Colapietro G; Slaby AE; Melemis SM; Bowman RK; Ohio State University, USA.
- The authors reviewed historical literature and hypothesized a relationship between epidemics of sexually transmitted diseases and foot fetishism. They tested this hypothesis by quantifying foot-fetish depictions in the mass-circulation pornographic literature during a 30-yr. interval. An exponential increase was noted
- Cytomegalovirus retinitis and the evolving AIDS epidemic [editorial]
- Retina. 1998;18(5):395-8. Unique Identifier : AIDSLINE MED/99015650
- Jabs DA
- Vitreomacular traction syndrome following highly active antiretroviral therapy in AIDS patients with cytomegalovirus retinitis.
- Retina. 1998;18(5):443-7. Unique Identifier : AIDSLINE MED/99015660
- Canzano JC; Reed JB; Morse LS; Department of Ophthalmology, University of California, Davis,; Sacramento 95816-7051, USA.
- PURPOSE: To report the development of vitreomacular traction syndrome (VMT) following highly active antiretroviral therapy (HAART) in AIDS patients with cytomegalovirus retinitis (CMV-R). METHODS: We identified two AIDS patients with evidence of CMV-R who later developed VMT follow
- [Cauda equina syndrome]
- Rev Prat. 1998 Nov 1;48(17):1959-64. Unique Identifier : AIDSLINE MED/99071565
- Bille-Turc F; Service de neurologie, fondation hopital Saint-Joseph,; Marseille.
- Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging [editorial]
- Unique Identifier : AIDSLINE MED/99070850
- Askanas V; Engel WK
- Sporadic inclusion-body myositis (s-IBM) is the most common, debilitating and progressive muscle disease beginning at the age 50 or later. The most characteristic pathologic feature is vacuolar degeneration of muscle fibers accompanied by intrafiber congophilia and clusters ( tangles ) of paired-helical filaments, con
- Low copy numbers of human T-cell lymphotropic virus type I (HTLV-I) tax-like DNA detected in the salivary gland of seronegative patients with Sjogren's syndrome in an HTLV-I endemic area.
- Scand J Rheumatol. 1998;27(6):435-40. Unique Identifier : AIDSLINE MED/99070856
- Mizokami A; Eguchi K; Moriuchi R; Futsuki Y; Terada K; Nakamura H; Miyamoto T; Katamine S; Department of Bacteriology, Nagasaki University School of; Medicine, Japan.
- To evaluate the hypothesis, proposed in previous reports from HTLV-I non-endemic areas, that HTLV-I is involved in a significant proportion, about a quarter, of Sjogren s syndrome patients who lack serum antibodies to the virus, we examined for the presence or absence of HTLV-I in DNA samples isolated from salivary gl
- [Long-term HIV infection and dialysis dependent renal failure in analgesic nephropathy]
- Ther Umsch. 1998 Sep;55(9):555-7. Unique Identifier : AIDSLINE MED/99005899
- Muller V; Opravil M; Medizinische Kliniken A, Departement Innere Medizin,; Universitatsspital Zurich.
- We report a case of advanced human immundeficiency virus infection and relapsing urinary tract infections due to analgesic nephropathy. The patient developed an urosepsis with multiorgan dysfunction syndrome and required dialysis. Inspite of this complicated course, for the first time thirteen years after diagnosis of
- [Clinical single case study (n-of-1 trial)]
- Ther Umsch. 1998 Sep;55(9):568-72. Unique Identifier : AIDSLINE MED/99005903
- Speich R; Departement Innere Medizin, Universitatsspital Zurich.
- We conducted a single case (N-of-1) randomized trial in two patients. In the first case with bronchiolitis obliterans after lung transplantation a beneficial effect of inhaled steroids could be documented. The second patient suffered from symptoms compatible with HIV-associated M. Addison improving after cortisone, bu
- [Painless, red-violet skin lesions during immunosuppression]
- Ther Umsch. 1998 Sep;55(9):583-5. Unique Identifier : AIDSLINE MED/99005907
- Pfister M; Vogt B; Departement Innere Medizin, Inselspital, Bern.
- A patient with painless, bluish-red skin lesions under immunosuppressive treatment for kidney transplantation is presented. The clinical and histological diagnosis was Kaposi s sarcoma. This is a rare but serious complication in the immunocompromised patient. Human Herpes virus 8 (HHV 8) was recently found in the lesi
- Detecting undetected HIV-1 variants in African children using degenerate polymerase chain reaction and sequence analyses.
- Trans R Soc Trop Med Hyg. 1998 May-Jun;92(3):294-5. Unique Identifier : AIDSLINE MED/99078394
- Nanteza M; Kasolo FC; Monze M; Gompels UA; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, University of London.
- Treatment outcome of an unselected cohort of tuberculosis patients in relation to human immunodeficiency virus serostatus in Zomba Hospital, Malawi.
- Unique Identifier : AIDSLINE MED/99078407
- Harries AD; Nyangulu DS; Kang'ombe C; Ndalama D; Glynn JR; Banda H; Wirima JJ; Salaniponi FM; Liomba G; Maher D; Nunn P
- There is little information about treatment outcome in patients with smear-negative pulmonary tuberculosis (PTB) or extrapulmonary tuberculosis (EPTB) treated under routine programme conditions in subsaharan Africa. A prospective study was carried out to determine treatment outcome in an unselected cohort of TB patien
- First identification of a species of Leishmania causing visceral leishmaniasis in the Sultanate of Oman, in a patient with AIDS.
- Trans R Soc Trop Med Hyg. 1998 May-Jun;92(3):356-7. Unique Identifier : AIDSLINE MED/99078412
- Scrimgeour EM; Barker DC; al-Waily A; Idris M; Lambson B; Nirmala V; Windsor JJ; Department of Medicine, Sultan Qaboos University, Al-Khod, Oman.
- Increasing frequency of tuberculosis among staff in a South African district hospital: impact of the HIV epidemic on the supply side of health care.
- Trans R Soc Trop Med Hyg. 1998 Sep-Oct;92(5):500-2. Unique Identifier : AIDSLINE MED/99078354
- Wilkinson D; Gilks CF; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Mtubatuba, South Africa. wilkinsd@mrc.ac.za
- To describe the changing frequency of tuberculosis among staff in a South African hospital, and to compare incidence in health workers with that in ancillary staff, the number and type of cases of tuberculosis among staff diagnosed between 1991 and 1996 were ascertained. The incidence rate of tuberculosis among health
- Serum procalcitonin concentrations in patients with pulmonary tuberculosis.
- Trans R Soc Trop Med Hyg. 1998 Sep-Oct;92(5):540-1. Unique Identifier : AIDSLINE MED/99078367
- Lawn SD; Obeng J; Acheampong JW; Griffin GE; Department of Medicine, School of Medical Sciences, University of; Science and Technology, Kumasi, Ghana.
- Estradiol inhibits allograft-inducible major histocompatibility complex class II antigen expression and transplant arteriosclerosis in the absence of immunosuppression.
- Unique Identifier : AIDSLINE MED/99084427
- Saito S; Foegh ML; Motomura N; Lou H; Kent K; Ramwell PW
- BACKGROUND: The etiology of transplant arteriosclerosis is unknown, but current data point to the alloimmune response. Previously, we found that estradiol-17beta (E2) with immunosuppressant cyclosporine abolishes major histocompatibility complex (MHC) class II expression in the allograft. This study determines the eff
- Apoptosis of T lymphocytes in liver and/or small bowel allografts during tolerance induction.
- Transplantation. 1998 Dec 15;66(11):1530-6. Unique Identifier : AIDSLINE MED/99084441
- Meyer D; Baumgardt S; Loeffeler S; Czub S; Otto C; Gassel HJ; Timmermann W; Thiede A; Ulrichs K; Department of Surgery, University of Wuerzburg, Germany.; 093154535-001@t-online.de
- BACKGROUND: Apoptosis of parenchymal cells has been described during allograft rejection. Immunologically privileged tissue in the mouse has been found to prevent rejection by initiating apoptosis of infiltrating lymphocytes. The aim of this study was to investigate whether apoptosis may play a role in T-cell regulati
- Renal abscesses in an AIDS patient caused by Aspergillus fumigatus.
- Urol Int. 1998 Oct;61(1):52-4. Unique Identifier : AIDSLINE MED/99011369
- Kummerle S; Wedler H; Academic Teaching Hospital of Tubingen University, Tubingen,; Germany.
- BACKGROUND: Aspergillus abscesses of the kidneys are very rare complications of AIDS which usually have fatal outcome. The 4 patients described in the literature, 2 of whom had bilateral involvement, died due to this opportunistic infection. METHODS: Case report of a 33-year-old patient with AIDS in stage C3 and asper
- Hepatozoon species infection in domestic cats: a retrospective study.
- Vet Parasitol. 1998 Oct;79(2):123-33. Unique Identifier : AIDSLINE MED/99021329
- Baneth G; Aroch I; Tal N; Harrus S; School of Veterinary Medicine, Hebrew University of Jerusalem,; Rehovot, Israel. baneth@agri.huji.ac.il
- Hepatozoon sp. is a protozoan parasite of peripheral blood neutrophils in cats. Feline hepatozoonosis has been reported infrequently and little is known about the pathogenesis of this infection. In order to further clarify clinicopathological characteristics of hepatozoonosis in domestic cats, a retrospecitve study of
- Phylogeographic patterns of feline immunodeficiency virus genetic diversity in the domestic cat.
- Virology. 1998 Nov 25;251(2):234-43. Unique Identifier : AIDSLINE GENBANK/U11820
- Carpenter MA; Brown EW; MacDonald DW; O'brien SJ; SAIC Frederick, National Cancer Institute-Frederick Cancer; Research and Development Center, Frederick, Maryland, 21702-1201,; USA.
- Feline immunodeficiency virus (FIV) has a worldwide distribution among feral and domesticated cats and in many cases induces immunodeficiency disease analogous to that of human acquired immune deficiency syndrome. FIV is genetically homologous to human immunodeficiency virus (HIV) in both genome organization and gene
- A plasma membrane localization signal in the HIV-1 envelope cytoplasmic domain prevents localization at sites of vesicular stomatitis virus budding and incorporation into VSV virions.
- Virology. 1998 Nov 25;251(2):244-52. Unique Identifier : AIDSLINE MED/99058174
- Johnson JE; Rodgers W; Rose JK; Departments of Genetics, Opthalmology and Visual Science, Yale; University, New Haven, Connecticut, 06510, USA.
- Previous studies showed that the HIV-1 envelope (Env) protein was not incorporated into vesicular stomatitis virus (VSV) virions unless its cytoplasmic tail was replaced with that of the VSV glycoprotein (G). To determine whether the G tail provided a positive incorporation signal for Env, or if sequences in the Env t
- Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.
- Virology. 1998 Nov 25;251(2):302-16. Unique Identifier : AIDSLINE MED/99058181
- Pandori M; Craig H; Moutouh L; Corbeil J; Guatelli J; Department of Medicine, Department of Pathology, Department of; Veterans Affairs Medical Center, San Diego, California, USA.
- The HIV-1 Nef protein is present within the virion and is processed there by the viral protease. Mutational analysis indicated that residues 54-60 in HIV-1 Nef were required for intravirion cleavage. When viruses were produced using T cell lines or primary lymphoblasts, these residues were also required for optimal vi
- Induction of interferon-alpha by glycoprotein D of herpes simplex virus: a possible role of chemokine receptors.
- Virology. 1998 Nov 25;251(2):317-26. Unique Identifier : AIDSLINE MED/99058182
- Ankel H; Westra DF; Welling-Wester S; Lebon P; Hopital Saint-Vincent-de-Paul, Faculte de Medecine; Cochin-Port-Royal, Universite Rene-Descartes, 82 Avenue; Denfert-Rochereau, Paris, 75014, France. hankel@infobiogen.fr
- The induction of type I interferons by most RNA viruses is initiated by virus-derived double-stranded (ds)RNA. However, retro- and DNA-viruses, which do not synthesize dsRNA, must rely on different mechanisms of induction. For human immunodeficiency virus type 1 (HIV-1), recombinant glycoproteins 120 or 160 suffice to
- Human herpesvirus-8 glycoprotein B interacts with Epstein-Barr virus (EBV) glycoprotein 110 but fails to complement the infectivity of EBV mutants.
- Virology. 1998 Nov 25;251(2):402-13. Unique Identifier : AIDSLINE GENBANK/AF092928
- Pertel PE; Spear PG; Longnecker R; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois, 60611, USA. p-pertel@nwu.edu
- To characterize human herpesvirus 8 (HHV-8) gB, the open reading frame was PCR amplified from the HHV-8-infected cell line BCBL-1 and cloned into an expression vector. To facilitate detection of expressed HHV-8 gB, the cytoplasmic tail of the glycoprotein was tagged with the influenza hemagglutinin (HA) epitope. Expre
- [HIV-1 integration and viral replication]
- Uirusu. 1998 Jun;48(1):19-25. Unique Identifier : AIDSLINE MED/98425345
- Masuda T; Department of Immunotherapeutics Medical Research, Dental; University, Tokyo, Japan.
- Sexual risk behavior changes among HIV+ and HIV-female injecting drug users over 4 years.
- Women Health. 1998;27(4):1-17. Unique Identifier : AIDSLINE MED/99012173
- Dolezal C; Ehrhardt AA; Meyer-Bahlburg HF; Liu X; Exner TM; Rabkin JG; Gorman JM; Marder K; Stern Y; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY 10032, USA.
- This paper examines the sexual risk behavior of female injecting drug users who participated in a 4 year longitudinal study. Both HIV+ and HIV- women showed increases in monogamy, decreases in the frequency of unprotected vaginal/anal sex, and decreases in a risk index score throughout the study. HIV+ women had fewer
- Women's self-reported condom use: intra and interpersonal factors.
- Women Health. 1998;27(4):19-32. Unique Identifier : AIDSLINE MED/99012174
- Soet JE; DiIorio C; Dudley WN; Rollins School of Public Health, Emory University, Atlanta, GA,; USA.
- In the past several years, the greatest proportionate increase in AIDS diagnoses has occurred among women. Yet, while the risk of HIV infection increases, female college students continue to report inconsistent HIV prevention behaviors. Past research on condom use among college women has focused on intrapersonal aspec
- Deceptive imprinting: a cosmopolitan strategy for complicating vaccination.
- Vaccine. 1998 Nov;16(19):1780-7. Unique Identifier : AIDSLINE MED/99011473
- Nara PL; Garrity R; Biological Mimetics Inc., Frederick, MD 21701, USA.
- Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120.
- Vaccine. 1998 Nov;16(19):1803-11. Unique Identifier : AIDSLINE MED/99011476
- Pinter A; Honnen WJ; Kayman SC; Trochev O; Wu Z; Laboratory of Retroviral Biology, Public Health Research; Institute, New York, NY 10016, USA. pinter@phri.nyu.edu
- Although it is known that some human immune sera possess potent neutralizing activities for primary viruses, the identity of the target epitopes mediating this neutralization is unknown, and currently available immunogens have not been able to induce such activities. Using recombinant fusion glycoproteins expressing n
- Efficient induction of protective anti-malaria immunity by recombinant adenovirus.
- Vaccine. 1998 Nov;16(19):1812-7. Unique Identifier : AIDSLINE MED/99011477
- Rodrigues EG; Zavala F; Nussenzweig RS; Wilson JM; Tsuji M; Department of Medical and Molecular Parasitology, New York; University School of Medicine, NY 10010, USA.
- The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-c
- DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans.
- Vaccine. 1998 Nov;16(19):1818-21. Unique Identifier : AIDSLINE MED/99011478
- Ugen KE; Nyland SB; Boyer JD; Vidal C; Lera L; Rasheid S; Chattergoon M; Bagarazzi ML; Ciccarelli R; Higgins T; Baine Y; Ginsberg R; Macgregor RR; Weiner DB; University of South Florida College of Medicine, Department of; Medical Microbiology and Immunology, Tampa 33612, USA.; kugen@com1.med.usf.edu
- Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition,
- Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.
- Vaccine. 1998 Nov;16(19):1828-35. Unique Identifier : AIDSLINE MED/99011480
- Kim JJ; Nottingham LK; Wilson DM; Bagarazzi ML; Tsai A; Morrison LD; Javadian A; Chalian AA; Agadjanyan MG; Weiner DB; Department of Chemical Engineering, University of Pennsylvania,; Philadelphia 19104, USA.
- DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine s ability to induce CTL response in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in
- Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees.
- Vaccine. 1998 Nov;16(19):1836-41. Unique Identifier : AIDSLINE MED/99011481
- Bagarazzi ML; Boyer JD; Ugen KE; Javadian MA; Chattergoon M; Shah A; Bennett M; Ciccarelli R; Carrano R; Coney L; Weiner DB; Allegheny University of the Health Sciences, Department of; Pediatrics, St Christopher's Hospital for Children, Philadelphia,; PA 19134, USA.
- A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We h
- Construction of attenuated HIV-1 accessory gene immunization cassettes.
- Vaccine. 1998 Nov;16(19):1872-9. Unique Identifier : AIDSLINE MED/99011487
- Ayyavoo V; Nagashunmugam T; Phung MT; Buckner C; Kudckodkar S; Le P; Reddy PJ; Santiago L; Patel M; Tea L; Weiner DB; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.
- Delivery of genetic expression cassettes into animals can effectively induce both humoral and cellular immunity to the expressed gene product. Previously, we used this strategy to immunize against HIV-1 structural and enzymatic proteins in mice, non-human primates and in humans. In contrast, the use of the accessory g
- Prediction of well-conserved HIV-1 ligands using a matrix-based algorithm, EpiMatrix.
- Vaccine. 1998 Nov;16(19):1880-4. Unique Identifier : AIDSLINE MED/99011488
- Schafer JR; Jesdale BM; George JA; Kouttab NM; De Groot AS; TB/HIV Research Laboratory, International Health Institute, Brown; University, Providence, RI 02912, USA.
- This preliminary study was undertaken to identify new human leucocyte antigens (HLA) ligands from human immunodeficiency virus type 1 (HIV-1) which are highly conserved across HIV-1 clades and which may serve to induce cross-reactive cytotoxic T lymphocytes (CTLs). EpiMatrix was used to predict putative ligands from H
- Induction of HIV-1 IIIb neutralizing antibodies in BALB/c mice by a chimaeric peptide consisting of a T-helper cell epitope of Semliki Forest virus and a B-cell epitope of HIV.
- Vaccine. 1998 Dec;16(20):1936-40. Unique Identifier : AIDSLINE MED/99012139
- Fernandez IM; Golding H; Benaissa-Trouw BJ; de Vos NM; Harmsen M; Nottet HS; Golding B; Puijk WC; Meloen RH; Snippe H; Kraaijeveld CA; Eijkman-Winkler Institute for Microbiology, Infectious Diseases; and Inflammation, University Hospital, Utrecht, The Netherlands.
- A colinearly synthesized peptide consisting of a H-2d restricted T-helper cell epitope of Semliki Forest virus (SFV) and triple repeats of sequence GPGRAF, derived from the V3 domain of HIV-1 strains, was used to immunize BALB/c (H-2d) mice. Pepscan analysis of sera from peptide-immunized mice revealed that the chimae
- Delayed progression of murine AIDS in C57BL/6 mice pre-immunized with a highly antigenic 10-mer peptide encoded by the murine AIDS defective virus gag p12 gene.
- Vaccine. 1998 Dec;16(20):2026-30. Unique Identifier : AIDSLINE MED/99012152
- Mizuochi T; Horino A; Uchida T; Department of Bacterial and Blood Products, National Institute of; Infectious Diseases, Tokyo, Japan. miz@nih.go.jp
- C57BL/6 (B6) mice were immunized with a highly antigenic 10-mer peptide (P12-10), which is encoded by the murine AIDS (MAIDS) defective virus gag p12 gene, emulsified in incomplete Freund s adjuvant (ICFA). One week later, the mice were inoculated with the MAIDS virus to see if the immunization affects progression of
- Genetic stability of oral polio vaccine prepared on primary monkey kidney cells or Vero cells--effects of passage in cell culture and the human gastrointestinal tract.
- Vaccine. 1998 Dec;16(20):2031-8. Unique Identifier : AIDSLINE MED/99012153
- Chezzi C; Dommann CJ; Blackburn NK; Maselesele E; McAnerney J; Schoub BD; National Institute for Virology, University of the Witwatersrand; Medical School, Johannesburg, South Africa. claudiac@niv.ac.za
- The genetic stability of the three Sabin oral poliovaccine (OPV) strains produced on either primary monkey kidney (VK) or Vero cell substrates was compared in vivo and in vitro by measuring the rate at which the bases most strongly associated with attenuation and reversion to neurovirulence (positions 480, 481, and 47
- Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection.
- Vaccine. 1998 Dec;16(20):2077-84. Unique Identifier : AIDSLINE MED/99012159
- Sjolander A; Baldwin TM; Curtis JM; Bengtsson KL; Handman E; CSL Limited, Parkville, Victoria, Australia. asjoland@csl.comm.au
- Vaccination with the native Parasite Surface Antigen 2 of Leishmania major with Corynebacterium parvum as adjuvant protects mice from leishmaniasis through a Th1 mediated response. Here we show that vaccination with a recombinant form of this protein, purified from Escherichia coli and administered in iscoms or with C
- Protective immunity against equine herpesvirus type-1 (EHV-1) infection in mice induced by recombinant EHV-1 gD.
- Virus Res. 1998 Jul;56(1):11-24. Unique Identifier : AIDSLINE MED/98455383
- Zhang Y; Smith PM; Tarbet EB; Osterrieder N; Jennings SR; O'Callaghan DJ; Department of Microbiology and Immunology, Louisiana State; University Medical Center, School of Medicine in Shreveport,; 71130, USA.
- The ability of recombinant preparations of equine herpesvirus type 1 (EHV-1) glycoprotein D (gD) to elicit specific antibody and T lymphocyte responses in the BALB/c mouse model of respiratory infection was investigated. Recombinant gD (rgD) expressed as a glutathione-S-transferase (GST) fusion protein in Escherichia
- A specific T-cell subset with CD4+/CD38- markers derived from HIV-1 carriers induces apoptosis in healthy donor-derived T-lymphocytes.
- Virus Res. 1998 Jul;56(1):115-22. Unique Identifier : AIDSLINE MED/98455391
- Kameoka M; Auwanit W; Suzuki S; Horikoshi H; Khlai-Khlam N; Meguro T; Yamada K; Tanaka Y; Yoshihara K; Luftig RB; Ikuta K; Section of Serology, Institute of Immunological Science, Hokkaido; University, Sapporo, Japan.
- Apoptosis is an important mechanism of human immunodeficiency virus type 1 (HIV-1)-induced T-cell depletion. Our recent findings revealed mitogenic stimulation-dependent apoptosis induction in healthy donor-derived peripheral blood T-lymphocytes after adsorption with defective HIV-1 particles through acquirement by a
- [Treatment of cytomegalovirus retinitis in AIDS with an intraocular sustained-release ganciclovir implant]
- Nippon Ganka Gakkai Zasshi. 1998 Aug;102(8):515-21. Unique Identifier : AIDSLINE MED/98426631
- Mochizuki M; Ikeda E; Yoshimura K; Hikita N; Nagata Y; Iwamoto A; Fujino Y; Eguchi S; Oka S; Kimura S; Department of Ophthalmology, Kurume University School of; Medicine, Fukuoka-ken, Japan.
- Active cytomegalovirus ( CMV ) retinitis in patients with acquired immunodeficiency syndrome (AIDS) was treated with an intraocular sustained-release ganciclovir implant. A total number of 19 implants were performed in 15 eyes
- Primary care of international adoptees [see comments]
- Am Fam Physician. 1998 Dec;58(9):2025-32, 2039-40. Unique Identifier : AIDSLINE MED/99078870
- Quarles CS; Brodie JH; USNR, Branch Medical Clinic, La Maddalena, Italy.
- International adoptees are presenting to family physicians with increasing frequency. U.S. citizens have adopted over 100,000 international children since 1979. Prospective parents may seek advice from their physician during the adoptive process. If available at all, medical information on the child is often scanty. H
- An AIDS patient's right to refuse life-sustaining treatment.
- Am Fam Physician. 1998 Dec;58(9):2161-4. Unique Identifier : AIDSLINE MED/99078876
- Majette GR; Howard University School of Law, Washington, DC 20008, USA.
- U.S. Public Health Service updates guidelines for HIV prophylaxis in health care workers.
- Am Fam Physician. 1998 Dec;58(9):2165-8. Unique Identifier : AIDSLINE MED/99078877
- Morey SS
- Significant decrease in AIDS deaths in 1997 [news]
- Am Fam Physician. 1998 Dec;58(9):2171. Unique Identifier : AIDSLINE MED/99078878
- Once-daily drug for persons with HIV [news]
- Am Fam Physician. 1998 Dec;58(9):2174-5. Unique Identifier : AIDSLINE MED/99078879
- The Th1/Th2 paradigm and allergic disorders.
- Allergy. 1998;53(46 Suppl):12-5. Unique Identifier : AIDSLINE MED/99041362
- Romagnani S; Istituto di Medicina Interna e Immunoallergologia, University of; Florence, Italy.
- The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora?
- Allergy. 1998;53(46 Suppl):20-5. Unique Identifier : AIDSLINE MED/99041364
- Wold AE; Department of Clinical Immunology, Goteborg University, Sweden.
- Multicenter study of contaminated percutaneous injuries in anesthesia personnel.
- Anesthesiology. 1998 Dec;89(6):1362-72. Unique Identifier : AIDSLINE MED/99072530
- Greene ES; Berry AJ; Jagger J; Hanley E; Arnold WP 3rd; Bailey MK; Brown M; Gramling-Babb P; Passannante AN; Seltzer JL; Southorn P; Van Clief MA; Venezia RA; Department of Anesthesiology, Albany Medical College, New York; 12208, USA. elliott_greene@ccgateway.amc.edu
- BACKGROUND: Anesthesia personnel are at risk for occupational infection with bloodborne pathogens from contaminated percutaneous injuries (CPIs). Additional information is needed to formulate methods to reduce risk. METHODS: The authors analyzed CPIs collected during a 2-yr period at 11 hospitals, assessed CPI underre
- Role of human immunodeficiency virus in primary pulmonary hypertension--case reports.
- Angiology. 1998 Dec;49(12):1005-11. Unique Identifier : AIDSLINE MED/99071017
- Pellicelli AM; Palmieri F; D'Ambrosio C; Rianda A; Boumis E; Girardi E; Antonucci G; D'Amato C; Borgia MC; II Department of Infectious Disease, IRCCS Lazzaro Spallanzani; Hospital, Rome, Italy.
- Previous cases of pulmonary hypertension (PH) in human immunodeficiency virus (HIV) infection have been reported in the literature. The role of HIV in PH is still debatable. The purpose of this report was to analyze whether HIV plays a direct or indirect role in PH pathogenesis. Between February and November 1997, 56
- [Vaccinations and systemic diseases. Vaccinations and immunosuppression]
- Ann Med Interne (Paris). 1998 Oct;149(6):351-60. Unique Identifier : AIDSLINE MED/99070157
- Bouchaud O; Mouas H; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris.
- The hypothesis of systemic disease flare up or onset triggered by vaccination cannot be confirmed by the analysis of data from the literature. In immune deficiency of any cause, immunization is of great interest to avoid preventable infectious diseases but the risk of adverse events and suboptimal immunologic response
- [Expanded program of vaccination. Results and prospects]
- Ann Med Interne (Paris). 1998 Oct;149(6):372-8. Unique Identifier : AIDSLINE MED/99070159
- Guerin N; Antona D; Centre International de l'Enfance et de la Famille, Bois de; Boulogne, Paris.
- The expanded program on immunization, jointly launched by WHO and UNICEF in 1974 aimed in the beginning at immunizing 80% of the children of the world against measles, tetanus, pertussis, poliomyelitis, diphtheria and tuberculosis. After reaching the objectives in 1990, countries have been urged towards eradication of
- The search for a potent DNA vaccine against AIDS: the enhancement of immunogenicity by chemical and genetic adjuvants.
- Unique Identifier : AIDSLINE MED/99071667
- Sasaki S; Tsuji T; Asakura Y; Fukushima J; Okuda K
- DNA vaccination is a new way to generate antigen specific immune responses by inoculating plasmid DNA encoding microbial genes. We believe that the use of immunologic adjuvants together with DNA
- Impaired production of Th1 cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients.
- Anticancer Res. 1998 Sep-Oct;18(5D):3951-5. Unique Identifier : AIDSLINE MED/99071673
- Sato M; Goto S; Kaneko R; Ito M; Sato S; Takeuchi S; Institute of Bioregulation, Kanagawa, Japan.
- BACKGROUND: A reported imbalance of Th1 and Th2 may be responsible for the occurrence and progress of certain diseases. Patients with advanced cancer may have impaired cell-mediated immunity caused by a switch from Th1 to Th2. We investigated the balance of Th1 and Th2 in cancer patients using two approaches. METHODS:
- Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions.
- Anticancer Res. 1998 Sep-Oct;18(5D):3957-64. Unique Identifier : AIDSLINE MED/99071674
- Inagawa H; Nishizawa T; Honda T; Nakamoto T; Takagi K; Soma G; Department of Molecular Medicine, Takano Hospital, Kumamoto,; Japan.
- BACKGROUND: The antitumor effect exerted by tumor necrosis factor (TNF) is characteristic in that it causes central necrosis of the tumor mass. Viable tumor cells surrounding the tumor mass remain, however, even after most of the mass is necrotized, and these cells gradually regrow and form tumors. To overcome this, w
- The association of skin diseases with human herpesvirus 8 infection in HIV carriers.
- Arch Virol. 1998;143(10):1881-92. Unique Identifier : AIDSLINE MED/99073309
- Na Ayuthaya PI; Inagi R; Auwanit W; Warachit P; Kullavanijaya P; Wessagowit V; Ungpakorn R; Loaphoomphan N; Piradhammanon P; Yamanishi K; Department of Medical Sciences, Ministry of Public Health,; Bangkok, Thailand.
- The seroprevalence to Kaposi s sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 (HHV-8) was surveyed in human immunodeficiency virus type 1 (HIV-1) carriers with or without skin diseases, and also in HIV-1 negative individuals in Thailand . Using an immunofluoresc
- Further characterization of HIV RNA synthesis early after cell-to-cell transmission infection.
- Arch Virol. 1998;143(10):1911-26. Unique Identifier : AIDSLINE MED/99073311
- Kok TW; Li P; Burrell CJ; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, Australia.
- Using a one-step model for cell-to-cell transmission of HIV infection we have identified two distinct phases of HIV RNA synthesis. The first phase (4 h-12 h p.i.) was marked by an increase in only the full-length 9 kb RNA, while the second phase (24 h p.i. onwards) comprised a significant increase in the levels of all
- Sequence comparison of the major capsid protein gene from 18 diverse iridoviruses.
- Unique Identifier : AIDSLINE MED/99073314
- Webby R; Kalmakoff J
- Insect iridoviruses (IV) have been found on all continents of the world and in a broad range of insect hosts. The host range for a single strain can cross several insect orders. This along with a paucity of molecular information on all but a few members has led to confusion in the taxonomy and classification of these
- Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives.
- Arch Virol. 1998;143(10):2003-10. Unique Identifier : AIDSLINE MED/99073318
- Fujiwara M; Okamoto M; Ijichi K; Tokuhisa K; Hanasaki Y; Katsuura K; Uemura D; Shigeta S; Konno K; Yokota T; Baba M; Rational Drug Design Laboratories, Fukushima, Japan.
- We have previously reported that ingenol derivatives are highly potent inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in acutely infected cells. In this study, however, we have found that some ingenol derivatives strongly enhance the replication of HIV-1 in chronically infected cells at nanomola
- Comparison of early events during infection of human and chimpanzee peripheral blood mononuclear cells with HIV-1.
- Arch Virol. 1998;143(11):2065-76. Unique Identifier : AIDSLINE MED/99073325
- Pischinger K; Zimmermann K; Eibl MM; Mannhalter JW; IMMUNO AG, Vienna, Austria.
- Differences in early events during entry and integration of HIV-1 into peripheral blood mononuclear cells (PBMC) might contribute to the absence of AIDS-like disease in chimpanzees as compared to humans. To address this question, we first tested the in vitro susceptibility of human and chimpanzee PBMC for infection wi
- A thermoresistant strain of feline immunodeficiency virus (FIV) with an altered cytopathic effect and a restricted cell tropism.
- Arch Virol. 1998;143(11):2093-107. Unique Identifier : AIDSLINE GENBANK/Y10614
- Alix C; Koehren F; Martin JP; Kirn A; Braunwald J; Unite INSERM U74, Faculte de Medecine, Strasbourg, France.
- A thermoresistant strain, designated m41, of feline immunodeficiency virus (FIV) was selected after 31 successive passages of chronically infected IRC4 cells at 41 degrees C. The wild-type virus (wt) which served as a control was cultivated the same number of times at 37 degrees C. In Crandell feline kidney cells (CrF
- Dissecting the mode of action of various HIV-inhibitor classes in a stable cellular system.
- Arch Virol. 1998;143(11):2109-31. Unique Identifier : AIDSLINE MED/99073328
- Klimkait T; Stauffer F; Lupo E; Sonderegger-Rubli C; Novartis Pharma, Inc., Basel, Switzerland.
- We describe a stable and sensitive HIV evaluation system, which discriminates HIV-specific membrane fusion and early transcription events and is suitable for high-throughput inhibitor screening. A human lymphocytic line, constitutively producing infectious HIV-1, serves as Env-positive donor. A second indicator cell l
- Contribution of T cells to the development of autoimmune diabetes in the NOD mouse model.
- Bioessays. 1998 Sep;20(9):750-7. Unique Identifier : AIDSLINE MED/99036999
- Toyoda H; Formby B; Department of Medicine, UCLA School of Medicine, Cedars-Sinai; Medical Center 90048, USA.
- The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that shares many immunogenetic features with human insulin-dependent diabetes mellitus (IDDM), type 1 diabetes. The mononuclear cell infiltrates in the islet, which results in the development of insulitis (a prerequisite step for the devel
- Dependencies of substitution steps number on Hamming distance are identical for one-parameter discrete models of both direct and parallel genetic diversity.
- J Biomol Struct Dyn. 1998 Aug;16(1):133-8. Unique Identifier : AIDSLINE MED/98416984
- Shchelkanov MY; Soinov LA; Zalunin VV; Starikov NS; Natan AA; Kireev VB; Karamov EV; Moscow Institute of Physics and Technology, Faculty of; Physiochemical Biology, Department of Molecular Biophysics,; Dolgoprudny, Russia.
- With the help of previously introduced enumeration procedure (M.Yu. Shchelkanov, A.N. Yudin, A.V Antonov, N.S. Starikov, A.A. Vedenov, E.V. Karamov, J. Biomol. Struct. Dyn. 15, 217-229 (1997)) and probability distribution function for the enumeration after some substitution steps (M.Yu. Shchelkanov, L.A. Soinov, V.V.
- Molecular modeling of HIV-1 coreceptor CCR5 and exploring of conformational space of its extracellular domain in molecular dynamics simulation.
- J Biomol Struct Dyn. 1998 Aug;16(1):77-90. Unique Identifier : AIDSLINE MED/98416979
- Efremov RG; Legret F; Vergoten G; Capron A; Bahr GM; Arseniev AS; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic; Chemistry, Russian Academy of Sciences, GSP, Moscow.; efremov@nmr.ru
- The chemokine receptor CCR5 functions as a major fusion coreceptor for macrophage-tropic human immunodeficiency virus entry into cell. Here we report a three-dimensional model of CCR5 built using molecular modeling approach. Because the virus binds to extracellular domain of the receptor, special attention was given t
- HIV vaccine development for the world: an idea whose time has come?
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S191-6. Unique Identifier : AIDSLINE MED/99030108
- Berkley S; The International AIDS Vaccine Initiative, New York, New York; 10013, USA.
- Lessons for AIDS vaccine development from non-AIDS vaccines.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S197-203. Unique Identifier : AIDSLINE MED/99030109
- Clements-Mann ML; Center for Immunization Research, Department of International; Health, School of Hygiene and Public Health, Johns Hopkins; University, Baltimore, Maryland 21205, USA. mclement@jhsph.edu
- Critical misconceptions about vaccine development have arisen in the context of acquired immunodeficiency syndrome (AIDS) vaccine research. These include: the goal of vaccination; the biological relevance and predictive value of animal models; the meaning of correlates of protective immunity ; the nature and duration
- HIV vaccine development and evaluation: realistic expectations.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S205-10. Unique Identifier : AIDSLINE MED/99030110
- Heyward WL; MacQueen KM; Goldenthal KL; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.
- As of January 1998, more than 85 vaccines for 24 clinical indications are currently licensed in the United States . From the time of discovery of the etiologic agent to the development of a licensed vaccine, many years have usually been required. Although many vaccines have been license
- Genetic variation of HIV type 1: relevance of interclade variation to vaccine development.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S211-21. Unique Identifier : AIDSLINE MED/99030111
- van der Groen G; Nyambi PN; Beirnaert E; Davis D; Fransen K; Heyndrickx L; Ondoa P; Van der Auwera G; Janssens W; Department of Microbiology, Institute of Tropical Medicine,; Antwerpen, Belgium. gvdgroen@itgt.be
- Accumulating data in human immunodeficiency virus (HIV)-infected individuals support the hypothesis that in primary human immunodeficiency virus type 1 (HIV-1) isolates of different clades and phenotype (syncytium inducing [SI] and nonsyncytium inducing [NSI]) common antigenic structures must exist that can stimulate
- HIV type 1 transmission probabilities: estimates from epidemiological studies.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S223-7. Unique Identifier : AIDSLINE MED/99030112
- Mastro TD; Kitayaporn D; HIV/AIDS Collaboration, Nonthaburi, Thailand.
- Virology and immunology of acute HIV type 1 infection.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S229-34. Unique Identifier : AIDSLINE MED/99030113
- Daar ES; Cedars-Sinai Burns & Allen Research Institute, Department of; Medicine, UCLA School of Medicine, Los Angeles, California 90048,; USA. Daar@cshs.org
- Primary or acute human immunodeficiency virus type 1 (HIV-1) infection is the stage of disease when virus first disseminates throughout the body of newly infected individuals. This process results in the seeding of lymphoid tissue and the central nervous system, and the induction of a specific humoral and cellular imm
- HIV type 1 infection in lymphoid tissue: natural history and model systems.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S235-9. Unique Identifier : AIDSLINE MED/99030114
- Kitchen SG; Zack JA; Department of Medicine, UCLA School of Medicine, Los Angeles,; California 90095-1678, USA.
- The pathogenesis of human immunodeficiency virus (HIV) in the lymphoid compartment has a dramatic effect on disease progression and important implications for therapeutic and vaccine strategies. Here we discuss current understanding of the pathogenesis of HIV in the lymphoid tissue. Various model systems that allow ex
- Chemokine receptors as HIV coreceptors: implications and interactions.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S241-6. Unique Identifier : AIDSLINE MED/99030115
- Rucker J; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA. doms@mail.med.upenn.edu
- Role of cellular adhesion molecules in HIV type 1 infection and their impact on virus neutralization.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S247-54. Unique Identifier : AIDSLINE MED/99030116
- Hioe CE; Bastiani L; Hildreth JE; Zolla-Pazner S; Department of Pathology, New York University Medical Center, New; York 10010, USA.
- While CD4 and several chemokine receptors are the principal receptors for human immunodeficiency virus type 1 (HIV-1) viruses, other cell membrane proteins also play a role in HIV-1 infection. A large array of host cell-derived membrane proteins, including adhesion molecules, are incorporated into the envelope of HIV-
- Maturation of immune responses to lentivirus infection: implications for AIDS vaccine development.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S255-9. Unique Identifier : AIDSLINE MED/99030117
- Montelaro RC; Cole KS; Hammond SA; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; rmont@pop.pitt,edu
- The evaluation of attenuated vaccines in the simian immunodeficiency virus and equine infectious anemia virus animal models has demonstrated the ability of this immunization strategy to elicit broad and enduring immune protection from virus exposure. The development of protective immunity by these attenuated virus vac
- Encouraging vaccine results from primate models of HIV type 1 infection.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S261-3. Unique Identifier : AIDSLINE MED/99030118
- Schultz A; Vaccine and Prevention Research Program, Division of AIDS, NIAID,; NIH, Rockville, Maryland 20892, USA.
- Challenge studies in primates have established that vaccine-induced protection against immunodeficiency viruses, even against mucosal routes of challenge, is attainable, and that sterile immunity is not required for protection. Intelligent use of such studies in primate models, coupled with in vitro measurements of
- Candidate vaccines protect macaques against primate immunodeficiency viruses.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S265-70. Unique Identifier : AIDSLINE MED/99030119
- Stott J; Hu SL; Almond N; Division of Retrovirology, National Institute for Biological; Standards and Control, Potters Bar, Herts, United Kingdom.
- The preclinical evaluation of the efficacy of potential vaccines against AIDS requires challenge models. The experimental infection of macaques with simian immunodeficiency virus, human immunodeficiency virus type 2 (HIV-2) or chimeric viruses have proven to be most valuable. The progress made using simian models to a
- Active and passive immunization against HIV type 1 infection in chimpanzees.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S271-6. Unique Identifier : AIDSLINE MED/99030120
- Murthy KK; Cobb EK; Rouse SR; McClure HM; Payne JS; Salas MT; Michalek GR; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78228-0147, USA.
- Several vaccine strategies have been developed to prevent primary infection with human immunodeficiency virus (HIV), and some of the candidate vaccines have been tested in chimpanzees to determine their safety, efficacy, and to delineate immune correlates of protection. To date, more than 25 vaccines representing acti
- Development of bivalent rgp120 vaccines to prevent HIV type 1 infection.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S277-89. Unique Identifier : AIDSLINE MED/99030121
- Berman PW; VaxGen, Inc., South San Francisco, California 94080, USA.; pwb@gene.co
- A new generation of bivalent gp120-based vaccines, effective against subtype B and subtype E viruses, has been developed. Antisera from rabbits and humans immunized with these vaccines are able to neutralize macrophage tropic and T-cell tropic viruses grown in activated peripheral blood mononuclear cells (PBMCs). Th
- Canarypox virus-based vaccines: prime-boost strategies to induce cell-mediated and humoral immunity against HIV.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S291-8. Unique Identifier : AIDSLINE MED/99030122
- Tartaglia J; Excler JL; El Habib R; Limbach K; Meignier B; Plotkin S; Klein M; Virogenetics Corporation, Troy, New York 12180, USA.
- Prime-boost immunization strategies against HIV.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S299-309. Unique Identifier : AIDSLINE MED/99030123
- Barnett SW; Klinger JM; Doe B; Walker CM; Hansen L; Duliege AM; Sinangil FM; Chiron Corporation, Emeryville, California 94608, USA.
- Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S311-9. Unique Identifier : AIDSLINE MED/99030124
- Arthur LO; Bess JW Jr; Chertova EN; Rossio JL; Esser MT; Benveniste RE; Henderson LE; Lifson JD; AIDS Vaccine Program, SAIC/Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702-1201, USA.
- Although most viral vaccines used in humans have been composed of live attenuated viruses or whole killed viral particles, the latter approach has received little attention in research on experimental primate immunodeficiency virus vaccines. Inactivation procedures involving heat or formalin appear to adversely affect
- Rationale for the testing and use of a partially effective HIV vaccine.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S321-3. Unique Identifier : AIDSLINE MED/99030125
- Vermund SH; School of Public Health, University of Alabama at Birmingham,; 35294-2170, USA. sten@uab.edu
- Advancing AIDSVAX to phase 3. Safety, immunogenicity, and plans for phase 3.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S325-31. Unique Identifier : AIDSLINE MED/99030126
- Francis DP; Gregory T; McElrath MJ; Belshe RB; Gorse GJ; Migasena S; Kitayaporn D; Pitisuttitham P; Matthews T; Schwartz DH; Berman PW; VaxGen, Inc., South San Francisco, California 94080, USA.
- AIDSVAX ( VaxGen , Inc., South San Francisco, CA), a possible vaccine to protect against human immunodeficiency virus type 1 (HIV-1) infection, is being tested for efficacy in phase 3 studies. It has been tested for potential efficacy in chimpanzees, and tested for safety and immunog
- Preventive HIV type 1 vaccine clinical trials: a regulatory perspective.
- AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S333-40. Unique Identifier : AIDSLINE MED/99030127
- Goldenthal KL; Vaillancourt JM; Geber A; Lucey DR; Division of Vaccines and Related Products Applications,Office of; Vaccines Research and Review, Center for Biologics Evaluation and; Research, Food and Drug Administration, Rockville, Maryland; 20852, USA.
- The clinical development of a human immunodeficiency virus (HIV) vaccine should be planned so that adequate safety and efficacy data can be obtained in an efficient manner to permit a risk/benefit assessment. Phase 1 and 2 studies should support the selection of an appropriate vaccine formulation, dose and schedule fo
- Global AIDS surveillance--Part I.
- Wkly Epidemiol Rec. 1998 Nov 27;73(48):373-6. Unique Identifier : AIDSLINE MED/99062546
- Global AIDS surveillance. Part II.
- Wkly Epidemiol Rec. 1998 Dec 4;73(49):381-4. Unique Identifier : AIDSLINE MED/99075145
- Treatment of depression in HIV-infected patients.
- J Psychiatry Neurosci. 1998 Nov;23(5):293-7. Unique Identifier : AIDSLINE MED/99062464
- Cazzullo CL; Bessone E; Bertrando P; Pedrazzoli L; Cusini M; University of Milan, Italy.
- BACKGROUND: Pharmacological treatment of depression in HIV-infected patients has been found to be effective. This study assessed the efficacy and feasibility of treatment with fluoxetine and the best method of administering the drug to patients with HIV infection. METHODS: Sixteen seropositive and 16 seronegative pati
- Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease?
- Biochemistry. 1998 Dec 8;37(49):17137-44. Unique Identifier : AIDSLINE MED/99080124
- Towler EM; Gulnik SV; Bhat TN; Xie D; Gustschina E; Sumpter TR; Robertson N; Jones C; Sauter M; Mueller-Lantzsch N; Debouck C; Erickson JW; Protein Chemistry Laboratory, Structural Biochemistry Program,; SAIC Frederick, Maryland 21702, USA. towlere@ncifcrf.gov
- To investigate the biochemical properties of the protease encoded by the human endogenous retrovirus, K10 (HERV-K), 213 amino acids of the 3 -end of the HERV-K protease (PR) open reading frame were expressed in Escherichia coli. Autocatalytic cleavage of the expressed polypeptide resulted in an 18.2 kDa protein which
- Substrates and inhibitors of human T-cell leukemia virus type I protease.
- Biochemistry. 1998 Dec 15;37(50):17514-8. Unique Identifier : AIDSLINE MED/99080164
- Ding YS; Rich DH; Ikeda RA; School of Chemistry and Biochemistry, Georgia Institute of; Technology, Atlanta 30332-0400, USA.
- HTLV-I is an oncogenic retrovirus that is associated with adult T-cell leukemia. HTLV-I protease and HTLV-I protease fused to a deca-histidine containing leader peptide (His-protease) have been cloned, expressed, and purified. The refolded proteases were active and exhibited nearly identical enzymatic activities. To b
- A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.
- Hum Gene Ther. 1998 Nov 1;9(16):2407-25. Unique Identifier : AIDSLINE MED/99045005
- Wong-Staal F; Poeschla EM; Looney DJ; Department of Pathology, University of California San Diego, La; Jolla 92093, USA.
- This Phase I study, Ribozyme Gene Therapy of HIV-1 Infection (UCSD HSC #971072, FDA BB-IND 6405), is a prospective, open-label trial of infusion of autologous gene-altered cells into asymptomatic HIV-1 seropositive individuals. The objectives of this trial are to test the safety, fe
- Hypothetical reasons of the HIV1-AIDS "tritherapy" failure. A challenging model [editorial] [see comments]
- Unique Identifier : AIDSLINE MED/99080866
- Mathe G
- Daily journals in France recently published a declaration of eight AIDS-assistance associations stating, because of already established resistance of most of types of HIV1 to the so called tritherapies 8,000 subjects in France will soon be in condition of treatment failure . Thi
- Combinations of three or four HIV virostatics applied in short sequences which differ from each other by drug rotation. Preliminary results of the viral loads and CD4 numbers [comment]
- Biomed Pharmacother. 1997;51(10):417-26. Unique Identifier : AIDSLINE MED/99080867
- Mathe G; Morette C; Hallard M; Blanquet D; Institut de Cancerologie et d'Immunologie & Hopital Suisse de; Paris, Issy-les-Moulineaux, France.
- This paper presents the evolution during its follow-up of a virostatic combination study of the type I-II trial conducted on ten AIDS-related complex (ARC) or acquired immunodeficiency syndrome (AIDS) patients [1, 9, respectively]. Its concept is based on the following original notions: a) it is not the number of the
- Potentialization of IL-2 effects on immune cells by oyster extract (JCOE) in normal and HIV-infected individuals.
- Biomed Pharmacother. 1997;51(10):427-9. Unique Identifier : AIDSLINE MED/99080868
- Achour A; Lachgar A; Astgen A; Chams V; Bizzini B; Tapiero H; Zagury D; Universite Pierre et Marie Curie, Laboratoire de Physiologie; Cellulaire, Paris, France.
- Peripheral blood mononuclear cells (PBMCs) are physiologically activated by interleukin (IL)-2. We found that oyster extract (JCOE) currently used as a functional nutrient enhanced in vitro the IL-2 dependent activation as measured by cell count. 3H-thymidine uptake an
- Phenylarsine oxide inhibits ex vivo HIV-1 expression.
- Biomed Pharmacother. 1997;51(10):430-8. Unique Identifier : AIDSLINE MED/99080869
- Arbault S; Edeas M; Legrand-Poels S; Sojic N; Amatore C; Piette J; Best-Belpomme M; Lindenbaum A; Vuillaume M; URA 1679 and UPR42 CNRS, Ecole Normale Superieure, Paris,; France.
- Phenylarsine oxide (PAO), which is described as an inhibitor of tyrosine phosphatase activity, inhibits H2O2 release from human peripheral blood mononuclear cells (PBMCs) as measured by electrochemistry. Since human immunodeficiency virus type 1 (HIV-1) replication is known to be favored under oxidative stress conditi
- A controlled trial of dapsone versus pyrimethamine-sulfadoxine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmosis in patients with AIDS.
- Biomed Pharmacother. 1997;51(10):439-45. Unique Identifier : AIDSLINE MED/99080870
- Payen MC; De Wit S; Sommereijns B; Clumeck N; CHU St Pierre, Division of Infectious Diseases, Brussels,; Belgium.
- Pneumocystis carinii pneumonia (PCP) is the most common opportunistic human immunodeficiency virus (HIV)-related infection, occurring in 85% of HIV infected patients without prophylaxis. Preventive treatment is required when CD4 cell count falls below 200 cells per cubic millimeter. Cotrimoxazole has been shown to be
- Cerebral infarction associated with vasculitis due to varicella zoster virus in patients infected with the human immunodeficiency virus.
- Biomed Pharmacother. 1997;51(10):449-54. Unique Identifier : AIDSLINE MED/99080872
- Picard O; Brunereau L; Pelosse B; Kerob D; Cabane J; Imbert JC; Service de Medecine Interne, Hopital Saint-Antoine, Paris,; France.
- Cases of herpes zoster ophtalmicus (HZO) with delayed contralateral hemiparesis caused by hemispheric stroke secondary to granulomatous angiitis have been reported and are a well-recognized complication of herpes zoster. Similar cases have been reported more recently during infection with human immunodeficiency virus
- Metabolic aspects of HIV: associated wasting.
- Biomed Pharmacother. 1997;51(10):455-60. Unique Identifier : AIDSLINE MED/99080873
- Melchior JC; Service de Nutrition, Groupe Hospitalier Bichat-C Bernard, Paris,; France.
- Despite recent progress in the treatment of human immunodeficiency virus (HIV) infection, wasting syndrome (WS) is now one of the major aspects of acquired immunodeficiency syndrome (AIDS). Malnutrition in HIV infected patients is characterised by a predominant loss of body cell mass (BCM), the amount of functional pr
- Two cases of cytomegalovirus infection revealed by hearing loss in HIV-infected patients.
- Biomed Pharmacother. 1997;51(10):461-3. Unique Identifier : AIDSLINE MED/99080874
- Meynard JL; el Amrani M; Meyohas MC; Fligny I; Gozlan J; Rozenbaum W; Roullet E; Frottier J; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.
- Neurological complications are particularly common during HIV infection. Among various opportunistic diseases, cytomegalovirus ( CMV ) is one of the most frequent causes of central and peripheral neurological manifestations. Pr
- Anti-HIV activity of N-1-adamantyl-4-aminophthalimide.
- Unique Identifier : AIDSLINE MED/99080875
- Van Derpoorten K; Balzarini J; De Clercq E; Poupaert JH; Ecole de Pharmacie, Faculte de Medecine, Universite Catholique; de Louvain, Bruselles, Belgium.
- The discovery of new leads acting via novel modes of action in the treatment of the human immunodeficiency virus (HIV), the causative agent of AIDS, remains a challenge. Along this line we synthesized and evaluated a series of N-substituted 4-aminophthalimides which were designed according to the models of thalidomide
- Frequencies of the CC chemokine receptor 5 delta 32 allele in various populations of defined racial background.
- Biomed Pharmacother. 1997;51(10):469-73. Unique Identifier : AIDSLINE MED/99080876
- Lucotte G; Regional Center of Molecular Neurogenetics (Service of; Neurology), Maison Blanche Hospital, Reims, France.
- The 32-nucleotide deletion (delta 32) within the chemokine co-receptor CCR5 gene was studied in 1,031 DNA samples from various racial origins. The mutation is absent in 48 Vietnamese living in Paris, and we confirm that delta 32 allele is very rare in a sample of 302 individuals originating from sub-Saharan Africa. Th
- Surgery in patients with HIV infection: indications and outcome.
- Biomed Pharmacother. 1997;51(10):474-9. Unique Identifier : AIDSLINE MED/99080877
- Eriguchi M; Takeda Y; Yoshizaki I; Akiyama N; Yanagie H; Fujii Y; Department of Surgery, University of Tokyo, Japan.
- We reviewed the records of 12 patients with HIV infection (one stage I, three stage II, two stage III, six stage IV) who received 15 surgical procedures under general or lumbar/epidural anesthesia. We discussed surgical indications, their poor wound healing and precautions for preventing the risk of transmission of HI
- B-cell epitopes in HIV-1 Tat and Rev proteins colocalize with T-cell epitopes and with functional domains.
- Biomed Pharmacother. 1997;51(10):480-7. Unique Identifier : AIDSLINE MED/99080878
- Tahtinen M; Ranki A; Valle SL; Ovod V; Krohn K; University of Tampere, Finland.
- We describe the characterization of the B-cell epitopes of HIV-1 regulatory proteins Tat and Rev. The prevalence of antibodies to these proteins among human immunodeficiency virus (HIV)-1-infected individuals was examined by enzyme-linked immunosorbent assay (ELISA) and by Western blotting. The Tat and Rev antibody-po
- [A report on 8 seronegative converted HIV/AIDS patients with traditional Chinese medicine]
- Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 May;17(5):271-3. Unique Identifier : AIDSLINE MED/99080243
- Lu WB; Wen RX; Guan CF; China Academy of Traditional Chinese Medicine, Beijing.
- OBJECTIVE: For the first time, serum anti-HIV antibody negative conversion was being reported. METHODS: Eight confirmed HIV/AIDS patients (AC1, ARC 6, AIDS 1) were treated with TCM recipes (802, 806, 809, 810, Shengmaiyin, ZY-1), recheck the serum antibody and immunological function and intranuclear HIV-DNA was invest
- [Clinical and experimental study on improving cellular immunological function of uterine myoma patients by xiaoliu tablet]
- Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 May;17(5):277-9. Unique Identifier : AIDSLINE MED/99080245
- Zhou J; Zhu M; Li YX; Yueyang Hospital affiliated to Shanghai University of TCM,; Shanghai.
- OBJECTIVE: To explore the effect of Xiaoliu Tablet (XLT) in treating uterine myoma (UM) and the relationship between effect and the cellular immunological function of the UM patients. METHODS: Seventy-one UM patients by treatment with XLT was observed. The activities of natural killer (NK) cells of 50 patients and 30
- [Clinical observation on 112 cases with non-Hodgkin's lymphoma treated by Chinese herbs combined with chemotherapy]
- Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 Jun;17(6):325-7. Unique Identifier : AIDSLINE MED/99080256
- Guo XM; Li JX; Yang XF; Henan Tumor Hospital, Zhengzhou.
- OBJECTIVE: To seek for the effective therapeutical method in treating non-Hodgkin s lymphoma (NHL). METHODS: One hundred and sixty seven patients with non-Hodgkin s lymphoma were randomly divided into two groups, the treatment group, which consisted of 112 cases using Chinese herbs
- Systemic Penicillium marneffei infection in a child with common variable immunodeficiency.
- J Formos Med Assoc. 1998 Nov;97(11):780-3. Unique Identifier : AIDSLINE MED/99089202
- Lin WC; Dai YS; Tsai MJ; Huang LM; Chiang BL; Department of Pediatrics, National Taiwan University Hospital,; Taipei.
- Penicillium marneffei is rarely pathogenic in humans. Most previously reported cases of P. marneffei infection were from Southeast Asia where patients were usually in an immunocompromised state due to human immunodeficiency virus (HIV) infection. The majority of the patients reported in Western countries were immunoco
- HIV vaccine partnerships offer hope to the developing world [news]
- BMJ. 1998 Dec 5;317(7172):1543. Unique Identifier : AIDSLINE MED/99103247
- Matthews H
- As HIV related deaths fall, increased numbers need treatment.
- Commun Dis Rep CDR Wkly. 1998 Nov 27;8(48):421. Unique Identifier : AIDSLINE MED/99062436
- AIDS and HIV infection worldwide.
- Commun Dis Rep CDR Wkly. 1998 Nov 27;8(48):429-30. Unique Identifier : AIDSLINE MED/99062437
- Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
- Bioorg Med Chem. 1998 Sep;6(9):1597-604. Unique Identifier : AIDSLINE MED/99018638
- Anizon F; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Severe D; Riou JF; Bailly C; Fabbro D; Meyer T; Aubertin AM; Universite Blaise Pascal, Synthese, Electrosynthese et Etude; de Systemes a Interet Biologique, UMR 6504, Aubiere, France.
- The indolocarbazole antibiotics staurosporine and rebeccamycin (1) are potent antitumor drugs targeting protein kinase C and topoisomerase I, respectively. To obtain staurosporine analogues from rebeccamycin, different structural modifications were performed: coupling of the sugar moiety to the second indole nitrogen,
- Brown and Tufts scientists among those to receive NIH funding for AIDS research [news]
- J Investig Med. 1998 Dec;46(9):421. Unique Identifier : AIDSLINE MED/99078769
- D'Auria J
- Acute paranoid reaction to saquinavir.
- Am J Health Syst Pharm. 1998 Oct 1;55(19):2016-7. Unique Identifier : AIDSLINE MED/99000969
- Finlayson JA; Laing RB; Infectious Diseases Unit, Aberdeen Royal Infirmary, Scotland.; j.finlayson@dial.pipex.com
- Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector.
- Gene Ther. 1998 May;5(5):635-44. Unique Identifier : AIDSLINE MED/99014602
- Richardson JH; Hofmann W; Sodroski JG; Marasco WA; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Boston, MA 02115, USA.
- A bicistronic human immunodeficiency virus type 1 (HIV-1)-based vector is described in which the expression of a selectable marker and a second gene of interest are forcibly coupled by means of an internal ribosome entry site. The vector provides high-level expression of the coselected gene in approximately 90% of tra
- MuLV-based vectors pseudotyped with truncated HIV glycoproteins mediate specific gene transfer in CD4+ peripheral blood lymphocytes.
- Unique Identifier : AIDSLINE MED/99014604
- Lodge R; Subbramanian RA; Forget J; Lemay G; Cohen EA
- Human immunodeficiency virus (HIV) infection ultimately leads to the destruction of the CD4+ lymphocyte subset and the onset of AIDS. In recent years, several gene therapy procedures making use of retroviral vectors that selectively target HIV susceptible cells have been proposed in order to interfere with HIV product
- Functional analysis of Ran/TC4 as a protein regulating T-cell costimulation.
- Cancer Gene Ther. 1998 Sep-Oct;5(5):259-73. Unique Identifier : AIDSLINE MED/99039651
- Nieland JD; Haks MC; Kremers BL; Leupers TJ; Bakker AQ; Offringa R; Kruisbeek AM; Division of Immunology, The Netherlands Cancer Institute, Antoni; van Leeuwenhoek Huis, Amsterdam.
- Antigen (Ag)-triggered activation of T cells requires engagement of both the T-cell Ag receptor and a costimulatory receptor, for which CD28 can function as a prototypical example. CD80 and CD86 represent ligands for this receptor, and although they are present on professional Ag-presenting cells, these molecules are
- Cytotoxic CD4+ T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo.
- Cancer Gene Ther. 1998 Sep-Oct;5(5):313-20. Unique Identifier : AIDSLINE MED/99039657
- Xiang J; Moyana T; Saskatoon Cancer Center, Department of Microbiology, College of; Medicine, University of Saskatchewan, Canada.
- Vaccination of mouse myeloma V(K)C(K)-gamma (I) cells secreting interferon (IFN)-gamma and expressing enhanced major histocompatibility complex (MHC) class I antigen (Ag) resulted in protective immunity that was mainly mediated by CD8+ T cells. V(K)C(K)-gamma (I/II) cells expressing both enhanced MHC class I and class
- Immunotherapy of established tumors in mice by intratumoral injection of interleukin-2 plasmid DNA: induction of CD8+ T-cell immunity.
- Cancer Gene Ther. 1998 Sep-Oct;5(5):321-30. Unique Identifier : AIDSLINE MED/99039658
- Saffran DC; Horton HM; Yankauckas MA; Anderson D; Barnhart KM; Abai AM; Hobart P; Manthorpe M; Norman JA; Parker SE; Vical Inc., San Diego, California 92121, USA.
- Intratumoral (i.t.) injection of a plasmid DNA vector encoding the murine interleukin-2 ( IL-2 ) gene was used to treat established renal cell carcinoma (Renca) tumors in BALB/c mice. Tumor regression was observed in 60-90% of mice that were injected i.t. for 4 days with
- Immunotoxin combined with chemotherapy for patients with AIDS-related non-Hodgkin's lymphoma.
- Cancer. 1998 Dec 15;83(12):2580-7. Unique Identifier : AIDSLINE MED/99089862
- Scadden DT; Schenkein DP; Bernstein Z; Luskey B; Doweiko J; Tulpule A; Levine AM; Massachusetts General Hospital, Harvard Medical School, Boston; 02129, USA.
- BACKGROUND: The objective of this study was to develop and test a combined therapeutic approach for patients with AIDS-related lymphoma (ARL), employing agents with independent mechanisms of action and nonoverlapping toxicity. This study was designed to test the feasibility and tolerance of combining low dose chemothe
- Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.
- Chem Biol. 1998 Oct;5(10):597-608. Unique Identifier : AIDSLINE MED/99035521
- Rodgers JD; Lam PY; Johnson BL; Wang H; Ko SS; Seitz SP; Trainor GL; Anderson PS; Klabe RM; Bacheler LT; Cordova B; Garber S; Reid C; Wright MR; Chang CH; Erickson-Viitanen S; DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0500,; USA. james.d.rodgers@dupontpharma.com
- BACKGROUND: Recent clinical trials have demonstrated that HIV protease inhibitors are useful in the treatment of AIDS. It is necessary, however, to use HIV protease inhibitors in combination with other antiviral agents to inhibit the development of resistance. The d
- 1H NMR conformational study on N-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure-activity relationships.
- J Pept Sci. 1998 Sep;4(6):400-10. Unique Identifier : AIDSLINE MED/99010883
- Mrestani-Klaus C; Fengler A; Brandt W; Faust J; Wrenger S; Reinhold D; Ansorge S; Neubert K; Department of Biochemistry and Biotechnology, Institute of; Biochemistry, Martin-Luther-University Halle-Wittenberg, Halle,; Germany.
- On the basis of our recent results, the N-terminal sequence of HIV-1 Tat protein as a natural competitive inhibitor of dipeptidyl peptidase IV (DP IV) is supposed to interact directly with the active site of DP IV hence mediating its immunosuppressive effects via specific DP IV interactions. Of special interest is the
- New tools for the diagnosis of tuberculosis: the perspective of developing countries [see comments]
- Int J Tuberc Lung Dis. 1998 Oct;2(10):778-83. Unique Identifier : AIDSLINE MED/98454842
- Foulds J; O'Brien R; Global Tuberculosis Programme, World Health Organization, Geneva,; Switzerland. fouldsj@who.ch
- New diagnostics for tuberculosis are urgently needed to replace or facilitate acid-fast bacilli (AFB) microscopy for the identification of smear-positive cases, and to improve the diagnosis of AFB smear-negative cases. These need to be appropriate for use in low income countries. Tests to replace or facilitate AFB mic
- Childhood human immunodeficiency virus and tuberculosis co-infections: reconciling conflicting data.
- Int J Tuberc Lung Dis. 1998 Oct;2(10):844-51. Unique Identifier : AIDSLINE MED/98454854
- Coovadia HM; Jeena P; Wilkinson D; Department of Paediatrics and Child Health, University of Natal,; Durban, South Africa.
- The impact of the human immunodeficiency virus (HIV) pandemic on childhood tuberculosis (TB) is unclear because of inconsistent and often contradictory findings in different types of studies. We review the evidence which supports or refutes the likelihood that HIV infection in children predisposes them to TB, and conc
- Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid A analog as an immunoadjuvant for synthetic vaccines.
- Chem Pharm Bull (Tokyo). 1998 Nov;46(11):1676-82. Unique Identifier : AIDSLINE MED/99062381
- Miyajima K; Nekado T; Ikeda K; Achiwa K; School of Pharmaceutical Sciences, University of Schizuoka,; Japan.
- Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity o
- Pathology of human immunodeficiency virus infection: noninfectious conditions.
- Ann Diagn Pathol. 1997 Oct;1(1):57-64. Unique Identifier : AIDSLINE MED/99086650
- Klassen MK; Lewin-Smith M; Frankel SS; Nelson AM; Department of Infectious and Parasitic Disease Pathology, Armed; Forces Institute of Pathology, Washington, DC, USA.
- Diagnostic anatomic pathologists play a crucial role in the battle against acquired immunodeficiency syndrome (AIDS). Not only are they intimately involved in the treatment of individual patients with human immunodeficiency virus (HIV) infection, but also they make important observations that result in the expansion o
- Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index.
- Bioorg Med Chem Lett. 1998 Jan 20;8(2):195-8. Unique Identifier : AIDSLINE MED/99088819
- Cushman M; Casimiro-Garcia A; Williamson K; Rice WG; Department of Medicinal Chemistry and Molecular Pharmacology,; School of Pharmacy and Pharmacal Sciences, Purdue University,; West Lafayette, Indiana 47907, USA.
- A novel alkenyldiarylmethane (ADAM) analog has been synthesized with enhanced potency as an anti-HIV agent. The new compound (ADAM II) inhibits the cytopathic effect of HIV-1RF in CEM-SS cells with an EC50 of 13 nM, while it shows cytotoxicity with a CC50 of 31.6 microM, providing a therapeutic index of 2430. ADAM II
- Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases.
- Bioorg Med Chem Lett. 1998 Mar 3;8(5):499-504. Unique Identifier : AIDSLINE MED/99088772
- Lutz MJ; Horlacher J; Benner SA; Department of Chemistry, ETH Zurich, Universitatstr,; Switzerland. michael.lutz@pharma.novartis.com
- HIV-1 reverse transcriptase (RT) incorporates 2 -deoxyisoguanosine triphosphate (d-isoGTP) opposite thymidine (T) in a DNA template and opposite uracil (U) in an RNA template about 10 times more efficiently than the eukaryotic DNA polymerase alpha, both in the absence and presence of dATP.
- Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines.
- Clin Exp Immunol. 1998 Dec;114(3):385-91. Unique Identifier : AIDSLINE MED/99062230
- Dieleman LA; Palmen MJ; Akol H; Bloemena E; Pena AS; Meuwissen SG; Van Rees EP; Departments of Gastroenterology, Faculty of Medicine, Vrije; Universiteit, Amsterdam, The Netherlands.
- Oral administration of DSS has been reported to induce an acute and chronic colitis in mice. The aim of our study was to evaluate if the chronic phase of DSS-induced colitis was characterized by a Th1/Th2 response and how this would relate to mucosal regeneration. Swiss Webster mice were fed 5% DSS in their drinking w
- Differential regulation of Th1 and Th2 cells by p91-110 and p21-40 peptides of the 16-kD alpha-crystallin antigen of Mycobacterium tuberculosis.
- Clin Exp Immunol. 1998 Dec;114(3):392-7. Unique Identifier : AIDSLINE MED/99062231
- Agrewala JN; Wilkinson RJ; Tuberculosis & Related Infections Unit, MRC Clinical Sciences; Centre, Imperial College School of Medicine, Hammersmith; Hospital, London, UK.
- Permissively recognized peptides which can activate lymphocytes from subjects with a variety of class II HLA types are interesting diagnostic and vaccine candidates. In this study we generated T helper clones reactive to the permissively recognized p21-40 and p91-110 peptides of the 16-kD heat shock protein of Mycobac
- Dynamics of serum cytokines in patients with visceral leishmaniasis and HIV-1 co-infection.
- Clin Exp Immunol. 1998 Dec;114(3):403-7. Unique Identifier : AIDSLINE MED/99062233
- Medrano FJ; Rey C; Leal M; Canavate C; Rubio A; Sanchez-Quijano A; Alvar J; Lissen E; Viral Hepatitis & AIDS Study Group, Department of Internal; Medicine, Hospital Universitario Virgen del Rocio, Seville,; Spain.
- Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con
- Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection.
- Clin Exp Immunol. 1998 Dec;114(3):414-21. Unique Identifier : AIDSLINE MED/99062235
- Kalinkovich A; Weisman Z; Greenberg Z; Nahmias J; Eitan S; Stein M; Bentwich Z; Ben-Ari Institute of Clinical Immunology, AIDS Centre, Kaplan; Medical Centre, Hebrew University Hadassah Medical School,; Rehovot, Israel.
- We have previously reported the presence of marked immune dysregulation with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in Israel heavily infected with helminths. In order to characterize better this immune dysregulation we studied by flow cytometry the e
- Motor neuron disease and HIV-1 infection in a 30-year-old HIV-positive heroin abuser: a causal relationship?
- Clin Neuropathol. 1998 May-Jun;17(3):131-5. Unique Identifier : AIDSLINE MED/98286968
- Galassi G; Gentilini M; Ferrari S; Ficarra G; Zonari P; Mongiardo N; Tommelleri G; Di Rienzo B; Department of Neurology, University of Modena, Italy.
- Although human retroviruses seem plausible agents of motor neuron diseases, there are only few reports of patients infected by the human immunodeficiency virus, with documented motor neuron disorder. That retroviral infections may cause motor neuron pathology by various mechanisms in animals and humans is known. Neuro
- A mediastinal mass in a patient with AIDS.
- Unique Identifier : AIDSLINE MED/99087219
- Eglin L; Jensen WA; Kirsch CM
- Homograft repair of a tuberculous pseudoaneurysm of the ascending aorta.
- Chest. 1998 Dec;114(6):1774-6. Unique Identifier : AIDSLINE MED/99087224
- Bojar RM; Turner MT; Valdez S; Haskal R; McGowan K; Khabbaz KR; Division of Cardiothoracic Surgery, New England Medical Center; and the Tufts University School of Medicine, Boston, MA 02111,; USA. robert.bojar@es.nemc.org
- A 34-year-old HIV-positive black man with pulmonary tuberculosis developed progressive widening of the mediastinum. Evaluation by CT and two-dimensional echocardiography demonstrated a large saccular aneurysm of the ascending aorta. This was repaired with a 26-mm aortic homograft using deep hypothermic circulatory arr
- Evaluation of a flow cytometric method for simultaneous leukocyte phenotyping and quantification by fluorescent microspheres.
- Cytometry. 1998 Nov 1;33(3):310-7. Unique Identifier : AIDSLINE MED/99038135
- Schlenke P; Frohn C; Kluter H; Saballus M; Hammers HJ; Zajac SR; Kirchner H; Institute of Immunology and Transfusion Medicine, University of; Luebeck School of Medicine, Germany. schlenke@immu.mu-luebeck.de
- We describe a flow cytometric method using a newly designed product, fluorochrome-containing microspheres (Flow Count fluorospheres), which facilitates the precise quantification of cells in whole blood samples or heterogeneous cell suspensions on a single-cell level. These microparticles are easily distinguishable fr
- [Benign symmetrical lipomatosis ("peripheral lipodystrophy") during antiretroviral therapy of HIV infection]
- Dtsch Med Wochenschr. 1998 Dec 11;123(50):1512-6. Unique Identifier : AIDSLINE MED/99095353
- Fischer T; Schworer H; Ramadori G; Abteilung Gastroenterologie und Endokrinologie, Medizinischen; Klinik der Universitat Gottingen.
- HISTORY AND ADMISSION FINDINGS: A 29-year-old hemophiliac with HIV infection for which he was receiving antiretroviral treatment (ART) with indinavir , zidovudine and zalcitabine reported increasing swelling of the neck. Physical examination noted a so
- [Metabolic changes induced by protease inhibitors. Expert Workshop of the Curatorium on Immune Deficiency, Munich, 15-17 October 1998, Weimar]
- Dtsch Med Wochenschr. 1998 Dec 11;123(50 Suppl Stoffwech):1-6. Unique Identifier : AIDSLINE MED/99099721
- Postural reflexes in patients with HIV-1 infection.
- Electroencephalogr Clin Neurophysiol. 1998 Oct;109(5):402-8. Unique Identifier : AIDSLINE MED/99066622
- Beckley DJ; Bloem BR; Martin EM; Panzer VP; Remler MP; Department of Neurology, School of Medicine, University of; California, Davis, USA.
- OBJECTIVE: We studied whether medium latency (ML) and long latency (LL) postural reflexes, which are abnormal in a number of neurological conditions including basal ganglia disorders, provide an early marker of CNS involvement in HIV-positive patients. METHODS: Leg reflexes were elicited in 9 neurologically normal HIV
- Hepatitis C in France: a national survey in the Departments of Internal Medicine and Infectious Diseases. The GERMIVIC (Joint Study Group on Hepatitis C virus of the French National Society of Internal Medicine and the French Society of Infectious Diseases).
- Eur J Epidemiol. 1998 Sep;14(6):545-8. Unique Identifier : AIDSLINE MED/99010535
- Raguin G; Rosenthal E; Cacoub P; Veyssier P; Piette JC; Micoud M; Service de Medecine Interne et Maladies Infectieuses, Hopital; de La Croix Saint Simon, Paris, France.
- Infection with Hepatitis C virus is a significant public health problem that has important clinical and financial consequences. Understanding of the epidemiology of HCV is needed to help define future therapeutic and preventive strategies. So far, the importance and characteristics of the epidemics have been best appr
- Prevalence of serologic markers of HBV, HDV, HCV and HIV in non-injection drug users compared to injection drug users in Gran Canaria, Spain.
- Eur J Epidemiol. 1998 Sep;14(6):555-61. Unique Identifier : AIDSLINE MED/99010537
- Santana Rodriguez OE; Male Gil ML; HernandezSantana JF; Liminana Canal JM; Martin Sanchez AM; Microbiology Service, Hospital Insular de Gran Canaria, Health; Sciences Center, Universidad de Las Palmas de Gran Canaria,; Spain.
- Injection drug use (IDU) is one of the most significant risk factors for viral hepatitis (B, D and C) and human immunodeficiency virus (HIV) infection. However, there is little information about the risk of infection among non-injection drug users (non-IDUs). The present study was designed to perform several objective
- Adjusting AIDS incidence for non-stationary reporting delays: a necessity for country comparisons.
- Eur J Epidemiol. 1998 Sep;14(6):595-603. Unique Identifier : AIDSLINE MED/99010542
- Gebhardt MD; Neuenschwander BE; Zwahlen M; Swiss Federal Office of Public Health, Division of Epidemiology; and Infectious Diseases, Bern, Switzerland.; Martin.Gebhardt@mbox.bag.admin.ch
- In many industrialized countries, infection with the human immunodeficiency virus (HIV) is one of the leading causes of mortality in adult persons below age 45. The incidence of the acquired immunodeficiency syndrome (AIDS) from surveillance systems is the most common indicator to compare the situation of the HIV-epid
- GBV-C RNA presence in several high-risk groups of Spain.
- Unique Identifier : AIDSLINE MED/99010545
- Quiros E; Piedrola G; Maroto MC; Department of Microbiology, Faculty of Medicine, University of; Granada, Spain.
- GB virus C subtype (GBV-C) seems to share the same routes of transmission as other parenteral transmitted viruses. We have evaluated the prevalence of GBV-C in 247 patients with potential risk for GBV-C infection and in 91 healthy blood donors. The presence of GBV-C RNA was examined by polymerase chain reaction in ser
- Fluconazole orally dispersible tablets for the treatment of patients with oropharyngeal candidiasis.
- J Int Med Res. 1998 Aug-Sep;26(4):209-18. Unique Identifier : AIDSLINE MED/99034097
- Vandercam B; Gibbs D; Valtonen M; Jager H; Armignacco O; Department of Internal Medicine, St Luc University Hospital,; Brussels, Belgium.
- The efficacy and tolerability of fluconazole orally dispersible tablets (ODT) in the treatment of oropharyngeal candidiasis was evaluated in this multicentre non-comparative study. A total of 89 adults with signs and symptoms of oropharyngeal candidiasis were enrolled; 70 of whom completed therapy with fluconazole ODT
- The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
- Genes Dev. 1998 Nov 15;12(22):3512-27. Unique Identifier : AIDSLINE GENBANK/AF087662
- Garber ME; Wei P; KewalRamani VN; Mayall TP; Herrmann CH; Rice AP; Littman DR; Jones KA; Regulatory Biology Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037-1099, USA.
- HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of the TAK/P-TEFb CTD kinase complex. Here we show that the cyclin domain of hCycT1 is necessary and sufficient to interact with Tat and promote cooperative binding to TAR RNA in vitro, as well as mediate Tat transactivation in
- Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.
- Hepatology. 1998 Dec;28(6):1669-73. Unique Identifier : AIDSLINE MED/99047514
- Xiong X; Flores C; Yang H; Toole JJ; Gibbs CS; Gilead Sciences, Foster City, CA, USA.
- To determine whether adefovir is active against lamivudine-resistant hepatitis B virus (HBV), the inhibition constants of adefovir diphosphate and lamivudine triphosphate for wild-type and mutant human HBV DNA polymerases, which contain amino acid substitutions associated with lamivudine resistance, were compared. Rec
- Better efficacy of a 12-month interferon alfa-2b retreatment in patients with chronic hepatitis C relapsing after a 6-month treatment: a multicenter, controlled, randomized trial. Le Groupe D'etude et De Traitement du Virus De L'hepatite C (Get.Vhc).
- Hepatology. 1998 Dec;28(6):1680-6. Unique Identifier : AIDSLINE MED/99047516
- Payen JL; Izopet J; Galindo-Migeot V; Lauwers-Cances V; Zarski JP; Seigneurin JM; Dussaix E; Voigt JJ; Selves J; Barange K; Puel J; Pascal JP; Service d'Hepato-Gastroenterologie, Purpan, Toulouse, France.; payen@cict.fr
- We studied the efficacy of three interferon alfa-2b (IFN-2b) regimens for the retreatment of patients with chronic hepatitis C (CHC) with prior complete response followed by relapse. Consecutive patients with CHC who had a complete biochemical response but relapse after a first course of 6 months of IFN with 3 million
- Sequential serum hepatitis C viral RNA levels longitudinally assessed by branched DNA signal amplification.
- Hepatology. 1998 Dec;28(6):1702-6. Unique Identifier : AIDSLINE MED/99047519
- Gordon SC; Dailey PJ; Silverman AL; Khan BA; Kodali VP; Wilber JC; Division of Gastroenterology-Hepatology, William Beaumont; Hospital, Royal Oak, MI, USA. sgordon@beaumont.edu
- The aim of this study was to determine the stability of viral load over an extended period in patients with chronic hepatitis C virus (HCV). Sequential serum specimens collected from fourteen non-alcoholic adult patients with chronic HCV between 1990 and 1997 were tested retrospectively for HCV RNA levels by branched
- The natural history of hepatitis C-A quandary [editorial; comment]
- Hepatology. 1998 Dec;28(6):1710-2. Unique Identifier : AIDSLINE MED/99047521
- Seeff LB
- Acute hepatitis in a patient treated with saquinavir and ritonavir: absence of cross-toxicity with indinavir [letter]
- Infection. 1998 Sep-Oct;26(5):313. Unique Identifier : AIDSLINE MED/99011886
- Vandercam B; Moreau M; Horsmans C; Gala JL
- Potential risk of enhancing survival of infected cells [letter]
- J Am Vet Med Assoc. 1998 Dec 15;213(12):1698. Unique Identifier : AIDSLINE MED/99078946
- LeGrand EK
- Images in clinical radiology. Lipoid pneumonia.
- J Belge Radiol. 1998 Oct;81(5):229. Unique Identifier : AIDSLINE MED/99097631
- Coche E; Hamoir X; Department of Radiology, Bruxelles, Belgium.
- Multifocal leukoencephalopathy.
- J Belge Radiol. 1998 Oct;81(5):241. Unique Identifier : AIDSLINE MED/99097641
- Gosselin R; De Maeseneer M; Stadnik T; Osteaux M; Department of Radiology, Academisch Ziekenhuis VUB, Brussels,; Belgium.
- Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
- J Biol Chem. 1998 Dec 4;273(49):32685-9. Unique Identifier : AIDSLINE PDB/1VSM
- Lubkowski J; Yang F; Alexandratos J; Merkel G; Katz RA; Gravuer K; Skalka AM; Wlodawer A; Macromolecular Structure Laboratory, ABL Basic Research Program,; NCI-Frederick Cancer Research and Development Center, National; Institutes of Health, Frederick, Maryland 21702, USA.
- Crystallographic studies of the catalytic core domain of avian sarcoma virus integrase (ASV IN) have provided the most detailed picture so far of the active site of this enzyme, which belongs to an important class of targets for designing drugs against AIDS. Recently, crystals of an inactive D64N mutant were obtained
- The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.
- J Biol Chem. 1998 Dec 11;273(50):33414-22. Unique Identifier : AIDSLINE MED/99057902
- Askjaer P; Jensen TH; Nilsson J; Englmeier L; Kjems J; Department of Molecular and Structural Biology, University of; Aarhus, C. F. Mollers Alle, Building 130, DK-8000 Aarhus C,; Denmark.
- Nuclear export of intron-containing human immunodeficiency virus type 1 (HIV-1) RNA is mediated by the viral Rev protein that contains both an RNA binding domain specific for the viral Rev response element (RRE) and a nuclear export signal (NES). The cellular CRM1 (Exportin1) protein functions as a nuclear export rece
- Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase.
- J Biol Chem. 1998 Dec 11;273(50):33624-34. Unique Identifier : AIDSLINE MED/99057931
- Harris D; Kaushik N; Pandey PK; Yadav PN; Pandey VN; Department of Biochemistry and Molecular Biology, University of; Medicine and Dentistry-New Jersey Medical School, Newark, New; Jersey 07103, USA.
- In order to understand the functional implication of residues constituting the dNTP-binding pocket of human immunodeficiency virus type 1 reverse transcriptase, we performed site-directed mutagenesis at positions 65, 72, 113, 115, 151, 183, 184, and 219, and the resulting mutant enzymes were examined for their biochem
- Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
- J Biol Chem. 1998 Dec 11;273(50):33781-6. Unique Identifier : AIDSLINE MED/99057951
- Lener D; Tanchou V; Roques BP; Le Grice SF; Darlix JL; LaboRetro, Unite de Virologie Humaine, INSERM 412, Ecole Normale; Superieure de Lyon, 46 Allee d'Italie, 69364 Lyon Cedex 07,; France.
- Retroviral reverse transcription takes place within the virion core, where nucleocapsid (NC) protein (NCp) molecules cover the dimeric RNA genome. NCp thus has structural roles in the virion core but is also extensively involved in viral DNA synthesis and virion assembly. To further characterize the role of human immu
- Effects of androgen administration on the growth hormone-insulin-like growth factor I axis in men with acquired immunodeficiency syndrome wasting.
- J Clin Endocrinol Metab. 1998 Dec;83(12):4251-6. Unique Identifier : AIDSLINE MED/99067084
- Grinspoon S; Corcoran C; Stanley T; Katznelson L; Klibanski A; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston 02114, USA.
- It is unknown whether hypogonadism contributes to decreased insulin-like growth factor I (IGF-I) production and/or how testosterone administration may effect the GH-IGF-I axis in human immunodeficiency virus (HIV)-infected men with the acquired immunodeficiency syndrome (AIDS) wasting syndrome (AWS). In this study, we
- Human immunodeficiency virus induction of corticotropin in lymphoid cells.
- J Clin Endocrinol Metab. 1998 Dec;83(12):4373-81. Unique Identifier : AIDSLINE MED/99067105
- Hashemi FB; Hughes TK; Smith EM; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555-0431, USA.
- Disruption of the linkage among the immune, nervous, and endocrine systems may contribute to the pathology and symptoms of acquired immunodeficiency syndrome (AIDS). We investigated the role of human immunodeficiency virus (HIV) in altering these linkages via induction of corticotropin (ACTH) by lymphocytes. Cultured
- Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.
- J Clin Invest. 1998 Dec 1;102(11):1933-41. Unique Identifier : AIDSLINE MED/99054988
- Yoneyama H; Harada A; Imai T; Baba M; Yoshie O; Zhang Y; Higashi H; Murai M; Asakura H; Matsushima K; Department of Molecular Preventive Medicine, School of Medicine,; and CREST, The University of Tokyo, Tokyo 113, Japan.
- Thymus and activation-regulated chemokine (TARC) is a recently identified lymphocyte-directed CC chemokine which specifically chemoattracts T helper type 2 CD4(+) T cells in human. To establish the pathophysiological roles of TARC in vivo, we investigated whether a monoclonal antibody (mAb) against TARC could inhibit
- Ex vivo analysis of cytotoxic T lymphocytes to measles antigens during infection and after vaccination in Gambian children.
- J Clin Invest. 1998 Dec 1;102(11):1969-77. Unique Identifier : AIDSLINE MED/99054992
- Jaye A; Magnusen AF; Sadiq AD; Corrah T; Whittle HC; Medical Research Council Laboratories, Banjul, The Gambia.; ajave@mrc.enda.sn
- The study of cytotoxic T cell responses to measles antigens during infection and after vaccination may provide insight into the immunopathology of the infection. It will also provide a knowledge of the immunity conferred by wild or attenuated virus, which will help in the design of new vaccines. Direct cytotoxic T cel
- Heat-related toxicity with the fentanyl transdermal patch [letter]
- J Pain Symptom Manage. 1998 Nov;16(5):277-8. Unique Identifier : AIDSLINE MED/99062450
- Newshan G
- Needle myringotomy: a useful technique with the increased prevalence of the human immunodeficiency virus.
- J Laryngol Otol. 1998 Sep;112(9):865-6. Unique Identifier : AIDSLINE MED/99093658
- Thorp MA; Department of Otolaryngology, University of Cape Town, Republic; of South Africa.
- Myringotomy is one of the most common procedures performed by ENT surgeons. Use of the tip of a hypodermic needle not only provides a neat and precise incision into the tympanic membrane, but is also a cheap and disposable means of doing so. Sterility is virtually guaranteed avoiding any possibility of cross contamina
- Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis.
- J Exp Med. 1998 Nov 16;188(10):1775-84. Unique Identifier : AIDSLINE MED/99034602
- Penny MJ; Boyd RA; Hall BM; Department of Medicine, Liverpool Hospital and the University of; New South Wales, Liverpool, New South Wales 2170, Australia.; pennymark@bigpond.com
- Active Heymann nephritis (HN) is a rat model of human idiopathic membranous nephropathy in which injury is thought to be mediated by membrane attack complex of complement (MAC) activated by antibody (Ab) to glomerular epithelial cells. Recent work has shown that HN develops in C6-deficient rats which cannot assemble M
- HIV-1 variation diminishes CD4 T lymphocyte recognition.
- Unique Identifier : AIDSLINE MED/99034603
- Harcourt GC; Garrard S; Davenport MP; Edwards A; Phillips RE
- Effective long-term antiviral immunity requires specific cytotoxic T lymphocytes and CD4(+) T lymphocyte help. Failure of these helper responses can be a principle cause of viral persistence. We sought evidence that variation in HIV-1 CD4(+) T helper epitopes might contribute to this phenomenon. To determine this, we
- In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.
- J Exp Med. 1998 Nov 16;188(10):1803-16. Unique Identifier : AIDSLINE MED/99034605
- Youn J; Chen J; Goenka S; Aronica MA; Mora AL; Correa V; Sheller JR; Boothby M; Department of Microbiology and Immunology, Department of; Medicine, Vanderbilt University Medical School, Nashville,; Tennessee 37232, USA.
- Strength of T cell receptor (TCR) signaling, coreceptors, costimulation, antigen-presenting cell type, and cytokines all play crucial roles in determining the efficiency with which type 2 T lymphocytes (Th2, Tc2) develop from uncommitted precursors. To investigate in vivo regulatory mechanisms that control the populat
- Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes.
- Unique Identifier : AIDSLINE MED/99034607
- Lehuen A; Lantz O; Beaudoin L; Laloux V; Carnaud C; Bendelac A; Bach JF; Monteiro RC; INSERM U 25, Hopital Necker, 75743 Paris, France.; lehuen@necer.fr
- Progression to destructive insulitis in nonobese diabetic (NOD) mice is linked to the failure of regulatory cells, possibly involving T helper type 2 (Th2) cells. Natural killer (NK) T cells might be involved in diabetes, given their deficiency in NOD mice and the prevention of diabetes by adoptive transfer of alpha/b
- c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms.
- J Exp Med. 1998 Nov 16;188(10):1859-66. Unique Identifier : AIDSLINE MED/99034610
- Ho IC; Lo D; Glimcher LH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115, USA.
- The c-maf protooncogene is a T helper cell type 2 (Th2)-specific transcription factor that activates the interleukin (IL)-4 promoter in vitro. Although it has been postulated that c-maf directs the Th2-specific expression of the IL-4 gene in vivo, direct evidence that c-maf functions during the differentiation of norm
- Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component.
- J Exp Med. 1998 Nov 16;188(10):1895-906. Unique Identifier : AIDSLINE MED/99034614
- Kopf M; Herren S; Wiles MV; Pepys MB; Kosco-Vilbois MH; Basel Institute for Immunology, CH-4005 Basel, Switzerland.
- Mice rendered deficient for interleukin (IL) 6 by gene targeting were evaluated for their response to T cell-dependent antigens. Antigen-specific immunoglobulin (Ig)M levels were unaffected whereas all IgG isotypes showed varying degrees of alteration. Germinal center reactions occurred but remained physically smaller
- A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling.
- J Exp Med. 1998 Nov 16;188(10):1917-27. Unique Identifier : AIDSLINE MED/99034616
- Burns JM; Gallo RC; DeVico AL; Lewis GK; Divisions of Basic Science and Vaccine Research, Institute of; Human Virology, University of Maryland Biotechnology Institute,; Baltimore, Maryland 21201, USA.
- The beta-chemokine RANTES (regulated on activation, normal T cell expressed and secreted) suppresses the infection of susceptible host cells by macrophage tropic strains of HIV-1. This effect is attributed to interactions of this chemokine with a 7-transmembrane domain receptor, CCR5, that is required for virus-cell f
- Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4.
- J Exp Med. 1998 Nov 16;188(10):1929-39. Unique Identifier : AIDSLINE MED/99034617
- Boirivant M; Fuss IJ; Chu A; Strober W; Mucosal Immunity Section, National Institutes of Health,; Bethesda, Maryland 20892, USA.
- In this study we describe oxazolone colitis, a new form of experimental colitis. This model is induced in SJL/J mice by the rectal instillation of the haptenating agent, oxazolone, and is characterized by a rapidly developing colitis confined to the distal half of the colon; it consists of a mixed neutrophil/lymphocyt
- Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
- J Exp Med. 1998 Nov 16;188(10):1955-65. Unique Identifier : AIDSLINE MED/99034619
- Betz UAK; Bloch W; van den Broek M; Yoshida K; Taga T; Kishimoto T; Addicks K; Rajewsky K; Muller W; Institute for Genetics, University of Cologne, D-50931 Cologne,; Germany.
- The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1 are mediated by the cytokine receptor subunit gp130 as the common signal transducer. Although mice lacking individual mem
- Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus.
- J Exp Med. 1998 Nov 16;188(10):1967-72. Unique Identifier : AIDSLINE MED/99034620
- Tebbey PW; Hagen M; Hancock GE; Department of Immunology Research, Wyeth-Lederle Vaccines and; Pediatrics, West Henrietta, New York 14586-9728, USA.
- We analyzed the immune responses evoked by a series of overlapping peptides to better understand the molecular basis for respiratory syncytial virus (RSV) G protein-induced eosinophilia in BALB/c mice. In vitro stimulation of spleen cells from natural G protein-primed mice showed dominant proliferative and cytokine (i
- HIV spread drops in some, but increases in others [news]
- Unique Identifier : AIDSLINE MED/99095305
- Number of deaths from AIDS drops in Oklahoma and United States [news]
- J Okla State Med Assoc. 1998 Dec;91(9):522. Unique Identifier : AIDSLINE MED/99105156
- Thrombopoietin levels in HIV-associated thrombocytopenia in children.
- J Pediatr. 1998 Dec;133(6):765-9. Unique Identifier : AIDSLINE MED/99059902
- Young G; Loechelt BJ; Rakusan TA; Nichol JL; Luban NL; Departments of Hematology/Oncology and Special Immunology,; Children's National Medical Center, Department of Pediatrics,; George Washington University School of Medicine, Washington, DC,; USA.
- OBJECTIVES: To determine the mechanism of human immunodeficiency virus (HIV)-associated thrombocytopenia by using thrombopoietin (TPO) levels.Study design: TPO levels were measured in 14 HIV+ children with thrombocytopenia (TCP+), 28 HIV+ children without thrombocytopenia (TCP-), and 15 matched control subjects. RESUL
- Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes.
- J Periodontol. 1998 Oct;69(10):1098-104. Unique Identifier : AIDSLINE MED/99017707
- Sigusch B; Klinger G; Glockmann E; Simon HU; Department of Periodontology, Conservative Dentistry, Friedrich; Schiller University Jena, Germany.
- There is growing evidence for an important role of the immune system in the pathogenesis of periodontitis. To further characterize the possible immunoregulatory dysfunction of peripheral blood mononuclear cells (PBMC) in periodontitis patients, we investigated functional aspects of PBMC from patients with early-onset
- Cytokine profiles of lesional and splenic T cells in Porphyromonas gingivalis infection in a murine model.
- J Periodontol. 1998 Oct;69(10):1131-8. Unique Identifier : AIDSLINE MED/99017713
- Gemmell E; Winning TA; Bird PS; Seymour GJ; Immunopathology Laboratory, Oral Biology and Pathology, School of; Dentistry, The University of Queensland, Brisbane, Australia.; e.gemmell@mailbox.uq.edu.au
- T cell cytokine profiles in the spleens and Porphyromonas gingivalis-induced lesions of P. gingivalis-immunized mice were examined. BALB/c mice were immunized with P. gingivalis outer membrane (OM) antigens/mouse weekly for 3 weeks followed by challenge with live organisms 2 weeks after the final immunization. Control
- Immediate placement of an endosseous root-form implant in an HIV-positive patient: report of a case.
- Unique Identifier : AIDSLINE MED/99017718
- Rajnay ZW; Hochstetter RL; Department of Veterans Affairs Medical Center, Canandaigua, NY; 14424, USA.
- Use of combination antiretroviral therapy regimens, including a protease inhibitor, has greatly improved the survival and systemic health of HIV-positive patients. Due to the esthetic requirements of the patient in this case report, placement of an endosseous implant into a fresh extraction site, restored with a singl
- Pharmacokinetics and tissue distribution of (+/-)-3'-azido-2',3'-dideoxy-5'-O-(2-bromomyristoyl)thymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine (AZT) in mice.
- J Pharm Pharmacol. 1998 Sep;50(9):989-96. Unique Identifier : AIDSLINE MED/99027284
- Parang K; Wiebe LI; Knaus EE; Faculty of Pharmacy and Pharmaceutical Sciences, University of; Alberta, Edmonton, Canada.
- The in-vivo biodistribution and pharmacokinetics in mice of 3 -azido-2 ,3 -dideoxythymidine (1, AZT ), 2-bromomyristic acid (2) and their common prodrug, (+/-)-3 -azido-2 ,3 -dideoxy-5 -O-(2-bromomyristoyl)thymidine (3) are reported. The objectives of
- Mycobacterium avium infection of gut mucosa in mice associated with late inflammatory response and intestinal cell necrosis.
- J Med Microbiol. 1998 Aug;47(8):725-31. Unique Identifier : AIDSLINE MED/99093021
- Kim SY; Goodman JR; Petrofsky M; Bermudez LE; Kuzell Institute for Arthritis and Infectious Diseases,; California Pacific Medical Center Research Institute, San; Francisco 94115, USA.
- Mycobacterium avium is an intracellular pathogen that is associated with disseminated infection in acquired immunodeficiency syndrome (AIDS). Patients with AIDS appear to acquire M. avium mainly through the gastrointestinal tract. Previous studies have shown that healthy mice given M. avium orally develop disseminated
- Detection of JC virus in two African cases of progressive multifocal leukoencephalopathy including identification of JCV type 3 in a Gambian AIDS patient.
- J Med Microbiol. 1998 Aug;47(8):733-42. Unique Identifier : AIDSLINE MED/99093022
- Stoner GL; Agostini HT; Ryschkewitsch CF; Mazlo M; Gullotta F; Wamukota W; Lucas S; Laboratory of Experimental Neuropathology, National Institutes of; Health, Bethesda, MD, USA.
- Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating central nervous system (CNS) infection, affecting mainly oligodendrocytes, but also occasional astrocytes. In the USA, Europe and Asia, PML is caused by the human polyomavirus JC virus (JCV) and in autopsy series occurs in about 4-7% of AIDS pat
- Pretreatment evaluation of chronic hepatitis C: risks, benefits, and costs.
- JAMA. 1998 Dec 23-30;280(24):2088-93. Unique Identifier : AIDSLINE MED/99091080
- Wong JB; Bennett WG; Koff RS; Pauker SG; Department of Medicine, New England Medical Center, Tufts; University School of Medicine, Boston, MA 02111, USA.; john.wong@es.nemc.org
- CONTEXT: Chronic hepatitis C (CHC) infection affects nearly 4 million people in the United States . Treatment with interferon alfa-2b has been limited by its cost and low likelihood of long-term response. OBJECTIVE: To examine the cost-effectiveness of alternative pretreatment managemen
- [Treatment of primary central nervous system lymphoma in AIDS patients (letter)]
- Med Clin (Barc). 1998 Oct 31;111(14):559. Unique Identifier : AIDSLINE MED/99076183
- Capote Huelva FJ; Calderon Sandubete E; Gil Garcia JL
- [Preventive work against HIV/AIDS has been successful in Sweden. But the global transmission is still unchanged]
- Lakartidningen. 1998 Nov 18;95(47):5267-9. Unique Identifier : AIDSLINE MED/99072952
- Haglind P; Goteborgs stads HIV/aids-fordelningsgrupp.
- [A new strategy in the fight against HIV/AIDS is needed. Inaccurate information is a waste of both money and energy]
- Lakartidningen. 1998 Nov 18;95(47):5300-2. Unique Identifier : AIDSLINE MED/99072959
- Christenson B; Lundbergh P; Parment PA; Sylvan S; Karolinska sjukhuset, Stockholm.
- Hepatitis. Advances in antiviral therapy for hepatitis.
- Lancet. 1998 Dec 19-26;352 Suppl 4:SIV15. Unique Identifier : AIDSLINE MED/99087167
- Berenguer M; Wright TL; Department of Veterans Affairs Medical Center, University of; California, San Francisco 94121, USA.
- HIV and AIDS. Gap between biology and reality in AIDS.
- Lancet. 1998 Dec 19-26;352 Suppl 4:SIV16. Unique Identifier : AIDSLINE MED/99087168
- Carr A; Cooper DA; St Vincent's Hospital, National Centre in HIV Epidemiology and; Clinical Research, University of New South Wales, Sydney,; Australia.
- Outbreak of primary and secondary syphilis--Guilford County, North Carolina, 1996-1997.
- MMWR Morb Mortal Wkly Rep. 1998 Dec 18;47(49):1070-3. Unique Identifier : AIDSLINE MED/99094241
- In 1996 and 1997, 153 cases of primary and secondary (P&S) syphilis were reported each year in Guilford County, North Carolina, a 147% increase from the 62 cases reported in 1994 (Figure 1). The incidence of P&S syphilis in Guilford County during 1996-1997 was 40.5 cases per 100,000 persons, substantially highe
- HIV testing among populations at risk for HIV infection--nine states, November 1995-December 1996.
- MMWR Morb Mortal Wkly Rep. 1998 Dec 25;47(50):1086-91. Unique Identifier : AIDSLINE MED/99098239
- Extending acquired immunodeficiency syndrome (AIDS) case surveillance systems to include confidential (name-based) reporting of human immunodeficiency virus (HIV) infections provides data representing recent HIV transmission patterns. These data may improve the ability of public health agencies to plan and evaluate HI
- HIV protease inhibitors influence the prevalence of oral candidosis in HIV-infected patients: a 2-year study.
- Mycoses. 1998 Sep-Oct;41(7-8):321-5. Unique Identifier : AIDSLINE MED/99078831
- Hoegl L; Thoma-Greber E; Rocken M; Korting HC; Department of Dermatology, Ludwig Maximilians University, Munich,; Germany.
- The introduction of HIV protease inhibitors was accompanied by reduction in HIV-associated opportunistic infections. Therefore, we performed a retrospective study of HIV-infected patients to evaluate the effects of therapy with an HIV protease inhibitor (PI) on oral
- Persistent oral candidosis by non-albicans Candida strains including Candida glabrata in a human immunodeficiency virus-infected patient observed over a period of 6 years.
- Mycoses. 1998 Sep-Oct;41(7-8):335-8. Unique Identifier : AIDSLINE MED/99078833
- Hoegl L; Thoma-Greber E; Rocken M; Korting HC; Department of Dermatology, Ludwig Maximilians University, Munich,; Germany.
- A 38-year-old woman infected with human immunodeficiency virus (HIV) presented with persistent oral candidosis in which non-albicans Candida strains were the predominant yeasts in most of the examinations performed over a period of 6 years. Oral treatment with fluconazole had no effect on clinical signs of oral candid
- Progressive multifocal leukoencephalopathy in the United States, 1979-1994: increased mortality associated with HIV infection.
- Neuroepidemiology. 1998;17(6):303-9. Unique Identifier : AIDSLINE MED/98453511
- Holman RC; Torok TJ; Belay ED; Janssen RS; Schonberger LB; Division of Viral and Rickettsial Diseases, National Center for; Infectious Diseases, Atlanta, Ga., USA. rch1@cdc.gov
- To examine trends in progressive multifocal leukoencephalopathy (PML) mortality in the United States , we analyzed PML death rates and deaths for 1979 through 1994, using US multiple cause-of-death data. During the 16-year study period 3,894 PML deaths were reported. The age-adjusted de
- [The use of hydrophobic PALL BB22-15MS filters in cross-infection prevention during anesthesia]
- Minerva Anestesiol. 1998 Oct;64(10):431-7. Unique Identifier : AIDSLINE MED/99074952
- Fabbri LP; Lo Nostro A; Filoni M; Merciai V; Loru G; Boncinelli S; Comodo N; Dipartimento di Fisiopatologia Clinica, Universita degli Studi,; Firenze.
- OBJECTIVE: Microbiological testing evaluations of hygienic procedure properties using PALL BB22-15MS filters to prevent contamination of single use breathing circuits during anesthesia. DESIGN: Prospective study. SETTING: Two operating rooms in a University hospital. PATIENTS: One hundred and thirty eight patients u
- Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains.
- Neurosci Lett. 1998 Sep 25;254(2):97-100. Unique Identifier : AIDSLINE MED/98451209
- Marshall DC; Wyss-Coray T; Abraham CR; Department of Biochemistry, The Arthritis Center, Boston; University School of Medicine, MA 02118-2394, USA.
- Human immunodeficiency virus (HIV)-1 can invade the brain and cause degeneration of the central nervous system, resulting in a host of cognitive and motor impairments. HIV-1 glycoprotein 120 (gp120), has been implicated in the neurodegenerative effects of HIV infection. Here, gp120 s neurotoxic potential is demonstrat
- Localized proton magnetic resonance spectroscopy of the brain in children infected with human immunodeficiency virus with and without encephalopathy.
- Unique Identifier : AIDSLINE MED/99020299
- Salvan AM; Lamoureux S; Michel G; Confort-Gouny S; Cozzone PJ; Vion-Dury J
- Twenty children older than 2 y infected with human immunodeficiency virus (HIV) were examined by in vivo proton magnetic resonance spectroscopy (1H MRS) to study their cerebral metabolism and to identify metabolic profiles in relation with different stages of the disease. Patients were rated regarding their clinical a
- [Fat distribution anomalies and other metabolic disorders in patients under antiretroviral therapy]
- Presse Med. 1998 Dec;27 Suppl 5:10-1. Unique Identifier : AIDSLINE MED/99095401
- Baril L; Service de Maladies Infectieuses et de Medecine Tropicale,; Hopital de la Pitie-Salpetriere, Paris.
- MORPHOLOGY: Certain HIV-infected patients develop fat distribution anomalies 3 to 6 months after the introduction of antiretroviral therapy. Partial or generalized lipodystrophy can be observed, in the form of central obesity with accumulation of fat in the cervicoscapular, thoracic, abdominal or hip areas. The underl
- [Observance, adherence, compliance ...different words for better therapeutic results]
- Presse Med. 1998 Dec;27 Suppl 5:13-4. Unique Identifier : AIDSLINE MED/99095402
- Baril L; Service de maladies Infectieuses et de Medecine Tropicale,; Hopital de la Pitie-Salpetriere, Paris.
- IMPROVING OBSERVANCE: For antiretroviral treatments including protease inhibitors , twice daily regimens have been tried instead of the t.i.d protocols. Available data are insufficient to determine the effect on observance. VERIFYING OBSERVANCE:
- [HHV-8 related diseases]
- Presse Med. 1998 Dec;27 Suppl 5:16. Unique Identifier : AIDSLINE MED/99095403
- Calvez V; Bossi P; Dpt de Virologie CERVI, Hopital de la Pitie-Salpetriere,; Paris.
- KAPOSI S DISEASE: HHV-8 sequences have been found in all the epidemiological forms of Kaposi s disease. There is a direct relationship between HHV-8 infection and PBMC and later development of Kaposi s disease. The HHV-8 sequences can be found in spindle cells or endothelial cells in Kaposi lesions. OTHER DISEASES: HH
- [Resistance to antiretroviral agents: mechanism and study methods]
- Presse Med. 1998 Dec;27 Suppl 5:18-9. Unique Identifier : AIDSLINE MED/99095404
- Bossi P; Calvez V; Bricaire F; Service de Maladies Infectieuses et Tropicales, Hopital; Pitie-Salpetriere, Paris.
- FREQUENT MUTATIONS: Associated with the high turnover rate of the HIV, frequent inverse transcriptase errors lead to a wide range of possible mutations. Certain mutations can modify the response to antiretroviral agents. The development of resistant strains is mediated by the selection pressure of antiretroviral agent
- [Opportunistic infections in patients under highly concentrated antiretroviral therapy]
- Presse Med. 1998 Dec;27 Suppl 5:21-2. Unique Identifier : AIDSLINE MED/99095405
- Jouan M; Service des Maladies Infectieuses et Tropicales, Groupe; Hospitalier Pitie-Salpetriere, Paris.
- VARIABLE RESULTS: The restoration of immunological competence following Highly Active AntiRetroviral Therapy (HAART) has led to promising results concerning cytomegalovirus viremia, atypical mycobacterium infections, and survival in patients treated for non-Hodgkin s lymphomas. The
- Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.
- Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14938-43. Unique Identifier : AIDSLINE GENBANK/AF104922
- Gonzalez-Cadavid NF; Taylor WE; Yarasheski K; Sinha-Hikim I; Ma K; Ezzat S; Shen R; Lalani R; Asa S; Mamita M; Nair G; Arver S; Bhasin S; Division of Endocrinology, Charles R. Drew University, Los; Angeles, CA 90059, USA. ncadavid@ucla.edu
- Myostatin, a member of the transforming growth factor-beta superfamily, is a genetic determinant of skeletal muscle growth. Mice and cattle with inactivating mutations of myostatin have marked muscle hypertrophy. However, it is not known whether myostatin regulates skeletal muscle growth in adult men and whether incre
- Early physiological abnormalities after simian immunodeficiency virus infection.
- Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15072-7. Unique Identifier : AIDSLINE MED/99061995
- Horn TF; Huitron-Resendiz S; Weed MR; Henriksen SJ; Fox HS; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA.
- Central nervous system (CNS) damage and dysfunction are devastating consequences of HIV infection. Although the CNS is one of the initial targets for HIV infection, little is known about early viral-induced abnormalities that can affect CNS function. Here we report the detection of early physiological abnormalities in
- Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.
- Pharm Acta Helv. 1998 Dec;73(4):215-8. Unique Identifier : AIDSLINE MED/99078863
- Mishra V; Pandeya SN; DeClercq E; Pannecouque C; Witvrouw M; Department of Applied Chemistry, Institute of Technology, Banaras; Hindu University, Varanasi, India.
- The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (HTLV-IIIB) and -HIV-2 (ROD) activity and cytotoxicity of the compounds were tested. The compound VII and VIII showed max
- Tuberculosis and HIV infection: a global perspective.
- Respiration. 1998;65(5):335-42. Unique Identifier : AIDSLINE MED/99000746
- Murray JF; Department of Medicine, University of California, San Francisco,; Calif., USA.
- The incidence of HIV-associated tuberculosis has been increasing worldwide since the beginning of the AIDS epidemic, and is expected to increase even further during the foreseeable future, especially in developing countries. There is no doubt now that, in the presence of HIV infection, new-onset tuberculous infection
- [Dementia and human inmmunodeficiency virus infection]
- Rev Neurol (Paris). 1998;154 Suppl 2:S91-8. Unique Identifier : AIDSLINE MED/99051614
- Gray F; Service d'Anatomie Pathologique, Medecine Legale,; Neuropathologie, Hopital Raymond Poincare-Faculte de Medecine; Paris-Ouest, Garches.
- HIV-associated neurological manifestations: dementia , myelopathy, and neuropathy, have become one of the commonest causes of neurological disorders in young people. Cognitive impairment develops in about 30 p. 100 of patients with AIDS and frank dementia in 15 to 20 p. 100 with an
- Interleukin-13's key role in asthma shown [news; comment]
- Science. 1998 Dec 18;282(5397):2168. Unique Identifier : AIDSLINE MED/99100165
- Vogel G
- AIDS vaccine trials in chimpanzees [letter]
- Science. 1998 Dec 18;282(5397):2195-6. Unique Identifier : AIDSLINE MED/99100171
- Prince AM; Andrus L
- Requirement for IL-13 independently of IL-4 in experimental asthma [see comments]
- Science. 1998 Dec 18;282(5397):2261-3. Unique Identifier : AIDSLINE MED/99074379
- Grunig G; Warnock M; Wakil AE; Venkayya R; Brombacher F; Rennick DM; Sheppard D; Mohrs M; Donaldson DD; Locksley RM; Corry DB; Department of Medicine, San Francisco General Hospital,; University of California San Francisco, San Francisco, CA 94143,; USA.
- The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phen
- Sex; death in agony: AIDS reversed [letter]
- S Afr Med J. 1998 Oct;88(10):1282-3. Unique Identifier : AIDSLINE MED/99024302
- Collins WG
- Preventing perinatal vertical HIV transmission in South Africa [letter]
- S Afr Med J. 1998 Oct;88(10):1283. Unique Identifier : AIDSLINE MED/99024303
- van de Wal BW
- The use of psychiatric rating scales--a note of caution [letter]
- S Afr Med J. 1998 Oct;88(10):1283-4. Unique Identifier : AIDSLINE MED/99024304
- van der Ryst E; Joubert G; Strydom W; Scott C; Boshoff W; Els C
- The complicated ethics of HIV vaccine trials.
- S Afr Med J. 1998 Oct;88(10):1288-9. Unique Identifier : AIDSLINE MED/99024306
- Galloway MR
- Hypertension and AIDS leading causes of SA maternal deaths.
- S Afr Med J. 1998 Oct;88(10):1289. Unique Identifier : AIDSLINE MED/99024307
- Jones JS
- Preventing transmission of HIV from mother to child--is South Africa ready and willing?
- S Afr Med J. 1998 Oct;88(10):1304-6. Unique Identifier : AIDSLINE MED/99024314
- Wilkinson D; McIntyre J
- National HIV surveillance in South Africa--1993-1995.
- S Afr Med J. 1998 Oct;88(10):1316-20. Unique Identifier : AIDSLINE MED/99024319
- Kustner HG; Swanevelder JP; van Middelkoop A; Health Systems Research, Department of Health, Pretoria.
- OBJECTIVE: To determine the point prevalence of HIV infection by serological examination which, performed consistently over several years, serves to monitor the distribution and trend of the HIV epidemic in South Africa . DESIGN: Annual cross-sectional surveys conducted nationally,
- The South African HIV epidemic, reflected by nine provincial epidemics, 1990-1996.
- S Afr Med J. 1998 Oct;88(10):1320-5. Unique Identifier : AIDSLINE MED/99024320
- Swanevelder JP; Kustner HG; van Middelkoop A; Health Systems Research, Department of Health, Pretoria.
- OBJECTIVES: To determine by serological examination the annual point prevalence rates of infection with the human immunodeficiency virus (HIV) in representative samples of subjects in the nine provinces of South Africa , 1990-1996. DESIGN: Annual cross-sectional point prevalence su
- Selective expansion of a peripheral blood CD8+ memory T cell subset expressing both granzyme B and L-selectin during primary viral infection in renal allograft recipients.
- Transplant Proc. 1998 Dec;30(8):3975-7. Unique Identifier : AIDSLINE MED/99082785
- ten Berge IJ; Wever PC; Rentenaar RJ; Spaeny LH; Surachno J; Wertheim PM; Schellekens PT; Hack CE; Academic Medical Center, Department of Clinical Immunology and; Rheumatology, University of Amsterdam, The Netherlands.
- Allospecific T-cell receptor V-beta repertoire in human mixed lymphocyte cultures is conserved and oligoclonally restricted.
- Transplant Proc. 1998 Dec;30(8):3984-5. Unique Identifier : AIDSLINE MED/99082789
- Mancia L; Camponeschi B; Parisi F; Vinciguerra G; Rossi P; Division of Immunology and Infectious Diseases, Children's; Hospital Bambino Gesu, Rome, Italy.
- Dissociation between chimerism and skin graft tolerance after neonatal injection of allogenic spleen cells.
- Transplant Proc. 1998 Dec;30(8):4018-9. Unique Identifier : AIDSLINE MED/99082800
- Donckier V; Flamand V; Abramowicz D; Goldman M; Laboratory of Experimental Immunology, Universite Libre de; Bruxelles, Belgium.
- Enhanced efficacy of repeated anti-CD8 monoclonal antibody therapy by high-dose cyclosporine treatment.
- Transplant Proc. 1998 Dec;30(8):4062-3. Unique Identifier : AIDSLINE MED/99082814
- Allan JS; Slisz JK; Vesga L; Arn JS; Yamada K; Sachs DH; Madsen JC; Division of Cardiac Surgery and Transplantation, Massachusetts; General Hospital, Harvard Medical School, Boston 02114, USA.
- Strategies for the treatment of intraocular inflammatory disease.
- Unique Identifier : AIDSLINE MED/99082838
- Nussenblatt RB; Schiffman R; Fortin E; Robinson M; Smith J; Rizzo L; Csaky K; Gery I; Waldmann T
- Bromocriptine markedly inhibits progression of murine retrovirus-induced immunodeficiency.
- Transplant Proc. 1998 Dec;30(8):4128-9. Unique Identifier : AIDSLINE MED/99082840
- Rosso di San Secondo VE; Fitch C; Aniasi A; Close FT; Sirchia G; Freeman ME; Department of Biological Science, Florida State University,; Tallahassee 32306-4340, USA.
- Successful treatment of autoimmune hemolytic anemia with intravenous immunoglobulin in a patient with AIDS.
- Transplant Proc. 1998 Dec;30(8):4151-2. Unique Identifier : AIDSLINE MED/99082849
- Gonzalez CA; Centro de Referencia Inmunohematologico, Uruguay, Buenos Aires,; Argentina.
- Variation in CD4+ T and CD8+ T lymphocyte subpopulations in bovine mammary gland secretions during lactating and non-lactating periods.
- Vet Immunol Immunopathol. 1998 Sep 16;65(1):51-61. Unique Identifier : AIDSLINE MED/99017562
- Asai K; Kai K; Rikiishi H; Sugawara S; Maruyama Y; Yamaguchi T; Ohta M; Kumagai K; T-Cell Research Institute, Sendai, Japan.
- Mammary gland secretions (MGS) of dairy cows at different stages of lactation were studied by immunofluorescence cytometry for T lymphocyte subpopulations using monoclonal antibodies. During early and late lactation, the mean ratio of CD4+/CD8+ T lymphocytes in the MGS was 0.5 and 0.8, respectively. A large proportion
- [Serological properties of HIV-1 isolates from the focus of an epidemic in the Gomel region of the Belarus Republic (1996)]
- Vopr Virusol. 1998 Sep-Oct;43(5):220-9. Unique Identifier : AIDSLINE MED/99082346
- Shchelkanov MIu; Iaroslavtseva NG; Iudin AN; Mirskov IuA; Eremin VF; Titov LP; Rytik PG; Karamov EV
- Immunoreactivity of sera obtained in 1996 from HIV-1-infected intravenous narcomaniacs from an epidemic focus in Gomel region, Belarus , is studied with a panel of 10-16-component synthetic peptides simulating apical epitope of surface glycoprotein gp120 V3 loop of HIV-1 variants.
- Utilizing an epidemiological profile for HIV prevention community planning in West Virginia.
- W V Med J. 1998 Nov-Dec;94(6):320-5. Unique Identifier : AIDSLINE MED/99085268
- Foglia G; Farr RW; Section of Infectious Diseases, Robert C. Byrd Health Sciences; Center of West Virginia University, Morgantown, USA.
- An epidemiologic profile revealed that approximately 1,000-1,600 persons in West Virginia are living with HIV, and that it is the 5th leading cause of death among persons ages 25-44. HIV is also the leading cause of death in black males ages 25-44 in WV, and blacks are disproportionately affected by HIV/AIDS (composin
- The seroprevalence of hepatitis and retroviral infection in Jamaican haemodialysis patients.
- West Indian Med J. 1998 Sep;47(3):105-7. Unique Identifier : AIDSLINE MED/99078855
- Barton EN; King SD; Douglas LL; Department of Medicine, University of the West Indies, Mona,; Jamaica.
- 63 haemodialysis (HD) patients and 63 age and gender matched controls were investigated for hepatitis B surface antigen (HbsAg) and antibodies to hepatitis B virus (anti-HBV), hepatitis C virus (anti-HCV), hepatitis D virus (anti-HDV), human immunodeficiency virus types 1 and 2 (anti-HIV-1 and 2) and human T-cell lymp
- A randomized double-blind study of the effect of distant healing in a population with advanced AIDS. Report of a small scale study.
- Unique Identifier : AIDSLINE MED/99083665
- Sicher F; Targ E; Moore D 2nd; Smith HS
- Various forms of distant healing (DH), including prayer and psychic healing, are widely practiced, but insufficient formal research has been done to indicate whether such efforts actually affect health. We report on a double-blind randomized trial of DH in 40 patients with advanced AIDS. Subjects were pair-matched f
- New tests for detecting HIV infection.
- West J Med. 1998 Dec;169(6):371-2. Unique Identifier : AIDSLINE MED/99083668
- Woehrle TA; Branson B
- Update on public health in correctional facilities.
- West J Med. 1998 Dec;169(6):374. Unique Identifier : AIDSLINE MED/99083671
- Puisis M
- [Is combination therapy of chronic hepatitis C with interferon alpha and ribavirin in primary interferon nonresponders indicated?--An analysis of personal experiences and review of the literature]
- Z Gastroenterol. 1998 Sep;36(9):819-27. Unique Identifier : AIDSLINE MED/99011503
- Wedemeyer H; Jackel E; Wedemeyer J; Frank H; Schuler A; Trautwein C; Manns MP; Abteilung fur Gastroenterologie und Hepatologie, Medizinische; Hochschule Hannover.
- Combination therapy of chronic hepatitis C with interferon alpha and ribavirin has been proven to be highly effective in naive and relapse patients with two to ten-fold increase of the response rate. However, combination therapy of primary non-responders to interferon
- Passive particle agglutination test for screening of Treponema Pallidum antibodies in blood bank routine.
- Acta Clin Belg. 1998 Oct;53(5):319-21. Unique Identifier : AIDSLINE MED/99078749
- De Bleser D; Van Renterghem L; Vandekerckhove B; Laboratorium voor bacteriologie en virologie Universitair; Ziekenhuis, De Pintelaan, Gent.
- In most laboratories and blood banks, the TP.PA test has replaced the TPHA test for the screening of Treponema pallidum antibodies. In this study we show that the 1:20 serum dilution should be used to discriminate between negative and positive samples instead of the recommended 1:40 dilution, thus increasing sensitivi
- Cellular interactions and adhesion molecules in psoriatic skin.
- Acta Derm Venereol Suppl (Stockh). 1994;186:15-8. Unique Identifier : AIDSLINE MED/99085319
- de Boer OJ; Verhagen CE; Visser A; Bos JD; Das PK; Department of Dermatology, University of Amsterdam, The; Netherlands.
- T-cell activation probably plays the most important role in hyperproliferation of keratinocytes in psoriasis. We present here our results concerning the interacting immunocompetent cells and their phenotypic and functional characteristics in relation to psoriasis pathology. Immunohistochemical analysis of skin biopsie
- Characterization of lesional psoriatic skin T lymphocyte clones.
- Acta Derm Venereol Suppl (Stockh). 1994;186:9-11. Unique Identifier : AIDSLINE MED/99085318
- Barna M; Snijdewint FG; van der Heijden FL; Bos JD; Kapsenberg ML; Department of Dermatology, University of Amsterdam, The; Netherlands.
- T cells are considered to play a role in the pathomechanism of psoriasis. Therefore we investigated the cytokine production patterns of T cell clones that were randomly prepared from chronic plaque psoriasis lesions of 2 patients. 67% of the 49 T lymphocyte clones (TLC) expressed CD4 and 33% expressed CD8 (ratio 2:1),
- Perivascular T cells are infected with HTLV-I in the spinal cord lesions with HTLV-I-associated myelopathy/tropical spastic paraparesis: double staining of immunohistochemistry and polymerase chain reaction in situ hybridization.
- Acta Neuropathol (Berl). 1998 Oct;96(4):340-6. Unique Identifier : AIDSLINE MED/99011021
- Matsuoka E; Takenouchi N; Hashimoto K; Kashio N; Moritoyo T; Higuchi I; Isashiki Y; Sato E; Osame M; Izumo S; The Division of Molecular Pathology and Genetic Epidemiology in; Center for Chronic Viral Diseases, Kagoshima University School of; Medicine, Sakuragaoka, Japan.
- HTLV-I-infected cells play an important role in pathogenesis HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Our previous studies of quantitative polymerase chain reaction (PCR) and in situ PCR suggested that T cells infiltrating in the spinal cord lesion were infected with HTLV-I. To elucidate th
- Molecular mechanisms of allergen-specific immunotherapy for atopic diseases.
- Chung Hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih. 1998 Sep-Oct;39(5):293-6. Unique Identifier : AIDSLINE MED/99041006
- Chiang BL; Graduate Institute of Immunology, Taipei, Taiwan.; gicmbor@ha.mc.ntu.edu.tw
- Increasing prevalence of atopic diseases has become a major problem in most developing and developed countries. In the past several years, most of our studies have focused on the regulatory mechanisms of immunotherapy and exploration of novel treatment for childhood asthma, including the regulation of type 1 (TH1) and
- [Latent AIDS in young children of mothers who were HIV-negative in the first trimester of pregnancy]
- Acta Med Port. 1998 Jul;11(7):691-5. Unique Identifier : AIDSLINE MED/99076615
- Cunha M; Preto L; Almeida H; Rodrigues G; Carvalho A; Correia M; Sequeira J; Servico de Pediatria, Hospital de Santa Maria, Lisboa.
- The authors describe two cases of infants admitted to our Unit with respiratory failure caused by a Pneumocystis Carinii pneumonia (PCP). Because their mothers were HIV negative in the first three months of pregnancy. HIV infection was not suspected and the diagnosis was only made after the PCP. Based on these example
- Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.
- Adv Exp Med Biol. 1998;440:415-23. Unique Identifier : AIDSLINE MED/98455629
- Liu MF; Ning Q; Pope M; Mosmann T; Leibowitz J; Ding JW; Fung LS; Rotstein O; Gorczynski R; Levy GA; Toronto Hospital, Canada.
- Murine hepatitis virus strain 3 (MHV-3) produces a host-strain-dependent spectrum of disease. The development of liver necrosis has been shown to be related to production of a unique macrophage procoagulant activity (PCA), encoded by the gene fgl-2, in susceptible mice. These studies were designed to examine the influ
- MHV-induced fatal peritonitis in mice lacking IFN-gamma.
- Adv Exp Med Biol. 1998;440:445-50. Unique Identifier : AIDSLINE MED/98455633
- Kyuwa S; Tagawa Y; Machii K; Shibata S; Doi K; Fujiwara K; Iwakura Y; Department of Animal Pathology, University of Tokyo, Japan.
- IFN-gamma gene was disrupted by homologous recombination in A3-1 embryonic stem cells. Germinally transmitted chimeric mice were successfully obtained and backcrossed with C57BL/6 (B6) mice 5 or 6 times. Deficiency of IFN-gamma in homozygous mice was confirmed by northern blot analysis of spleen cells stimulated with
- Intrahepatic alpha beta-TcRintermediate LFA-1high T cells are stimulated during mouse hepatitis viral infection.
- Adv Exp Med Biol. 1998;440:479-83. Unique Identifier : AIDSLINE MED/98455638
- Lamontagne L; Massicotte E; Page C; Departement des Sciences Biologiques, Universite du Quebec a; Montreal, Canada.
- Mouse hepatitis virus type 3 (MHV3), a coronavirus, is an excellent animal model for the study of thymic and extrathymic T cell subpopulation disorders induced during the viral hepatitis. To understand local hepatic immune responses, the phenotypes of resident hepatic lymphocytes were determined and compared that of s
- Clonal deletion of some V beta+ T cells in peripheral lymphocytes from C57BL/6 mice infected with MHV3.
- Adv Exp Med Biol. 1998;440:485-9. Unique Identifier : AIDSLINE MED/98455639
- Gagne S; Thibodeau L; Lamontagne L; Centre de Recherche en Virologie, Institut Armand-Frappier,; Laval, Quebec, Canada.
- Mouse hepatitis virus type 3 infection is generally accompanied by a severe immune dysfunction involving thymic or splenic T cell subpopulations. We postulate that the peripheral lymphoid cell depletions were caused by a selective deletion of some V beta subsets of mature T cells, as observed with superantigens. We ha
- Iatrogenically induced cortical blindness associated with leptomeningeal enhancement.
- AJNR Am J Neuroradiol. 1998 Sep;19(8):1522-4. Unique Identifier : AIDSLINE MED/98434352
- Petrus LV; Lois JF; Lo WW; Department of Radiological Sciences, Olive View-UCLA Medical; Center, Sylmar, CA 91342, USA.
- Leptomeningeal enhancement is usually infective or neoplastic in origin. We present a case in which a patient received total parenteral nutrition via a catheter unknowingly placed within the right vertebral artery. We postulate that the hyperosmolar nature of the infused solution induced temporary osmotic disruption o
- Culturally sensitive AIDS educational videos for African American audiences: effects of source, message, receiver, and context.
- Am J Community Psychol. 1998 Oct;26(5):705-43. Unique Identifier : AIDSLINE MED/99078684
- Herek GM; Gillis JR; Glunt EK; Lewis J; Welton D; Capitanio JP; Psychology Department, University of California, Davis; 95616-8775, USA.
- The importance of using culturally sensitive educational materials in HIV-related interventions with racial and ethnic minority groups is widely recognized. However, little empirical research has been conducted to assess the relative effectiveness of different techniques for creating culturally sensitive AIDS educatio
- Probable transmission of HIV from an orthopedic surgeon to a patient in France [see comments]
- Ann Intern Med. 1999 Jan 5;130(1):1-6. Unique Identifier : AIDSLINE MED/99087454
- Lot F; Seguier JC; Fegueux S; Astagneau P; Simon P; Aggoune M; van Amerongen P; Ruch M; Cheron M; Brucker G; Desenclos JC; Drucker J; Reseau National de Sante Publique, Saint-Maurice, France.; Lot@b3e.jussieu.fr
- BACKGROUND: Transmission of HIV from infected health care workers to patients has been documented in only one cluster involving 6 patients of a dentist in Florida. In October 1995, the French Ministry of Health offered HIV testing to patients who had been operated on by an orthopedic surgeon in whom AIDS was recently
- Misdiagnosis of HIV infection by HIV-1 plasma viral load testing: a case series.
- Ann Intern Med. 1999 Jan 5;130(1):37-9. Unique Identifier : AIDSLINE MED/99087459
- Rich JD; Merriman NA; Mylonakis E; Greenough TC; Flanigan TP; Mady BJ; Carpenter CC; Brown University School of Medicine, Providence, Rhode Island; 02906, USA. josiah_rich@Brown.edu
- BACKGROUND: The availability of sensitive assays for plasma HIV viral load and the trend toward earlier and more aggressive treatment of HIV infection has led to the inappropriate use of these assays as primary tools for the diagnosis of acute HIV infection. OBJECTIVE: To describe limitations in the use of plasma vira
- Occupational exposures to body fluids among medical students. A seven-year longitudinal study [see comments]
- Ann Intern Med. 1999 Jan 5;130(1):45-51. Unique Identifier : AIDSLINE MED/99087461
- Osborn EH; Papadakis MA; Gerberding JL; Palo Alto Medical Foundation, California 94301, USA.
- BACKGROUND: Medical students may be at high risk for occupational exposures to blood. OBJECTIVE: To measure the frequency of medical students exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN: Re
- Provider-to-patient HIV transmission: how to keep it exceedingly rare [editorial; comment]
- Ann Intern Med. 1999 Jan 5;130(1):64-5. Unique Identifier : AIDSLINE MED/99087464
- Gerberding J
- AIDS exceptionalism [letter]
- Ann Intern Med. 1999 Jan 5;130(1):79; discussion 80. Unique Identifier : AIDSLINE MED/99087477
- Bolan RK
- AIDS exceptionalism [letter]
- Ann Intern Med. 1999 Jan 5;130(1):79-80. Unique Identifier : AIDSLINE MED/99087478
- Bessesen M; McCollum M
- AIDS exceptionalism [letter]
- Ann Intern Med. 1999 Jan 5;130(1):80. Unique Identifier : AIDSLINE MED/99087479
- Frothingham R
- Characteristics of primary HIV infection [letter]
- Ann Intern Med. 1999 Jan 5;130(1):80-1. Unique Identifier : AIDSLINE MED/99087480
- Silvers AA
- Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac.
- Ann Neurol. 1998 Dec;44(6):942-7. Unique Identifier : AIDSLINE MED/99066764
- Lehky TJ; Levin MC; Kubota R; Bamford RN; Flerlage AN; Soldan SS; Leist TP; Xavier A; White JD; Brown M; Fleisher TA; Top LE; Light S; McFarland HF; Waldmann TA; Jacobson S; Neuroimmunology Branch, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda,; MD, USA.
- Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at
- HIV infection in children: the widening gap between developing and industrialized countries.
- Ann Trop Paediatr. 1998 Sep;18 Suppl:S15-20. Unique Identifier : AIDSLINE MED/99093543
- Coulter JB; Tropical Child Health, Liverpool School of Tropical Medicine, UK.
- AIDS hospices and orphanages.
- Ann Trop Paediatr. 1998 Sep;18 Suppl:S21-5. Unique Identifier : AIDSLINE MED/99093544
- Martin T; Liverpool School of Tropical Medicine, UK.
- L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350).
- Antiviral Res. 1998 Aug;39(2):101-11. Unique Identifier : AIDSLINE MED/99021324
- Robinson WE Jr; Department of Pathology, University of California, Irvine,; 92697-4800, USA. ewrobins@uci.edu
- Combinations of anti-human immunodeficiency virus (HIV) drugs, including reverse transcriptase inhibitors and protease inhibitors , have proven immensely potent in the therapy of acquired immune deficiency syndrome (AIDS). To determine whether HIV integrase is a suit
- Robustaflavone, a potential non-nucleoside anti-hepatitis B agent.
- Antiviral Res. 1998 Aug;39(2):81-8. Unique Identifier : AIDSLINE MED/99021322
- Zembower DE; Lin YM; Flavin MT; Chen FC; Korba BE; MediChem Research, Inc., Lemont, IL 60439, USA.
- Robustaflavone, a naturally occurring biflavanoid isolated from Rhus succedanea, was found to be a potent inhibitor of hepatitis B virus (HBV) replication in 2.2.15 cells, with an effective concentration (EC50) of 0.25 microM, and a selectivity index (SI, IC50/EC90) of 153. Robustaflavone hexaacetate inhibited HBV rep
- Ethambutol in tuberculosis: time to reconsider?
- Arch Dis Child. 1998 Sep;79(3):274-8. Unique Identifier : AIDSLINE MED/99092188
- Graham SM; Daley HM; Banerjee A; Salaniponi FM; Harries AD; College of Medicine, University of Malawi, Chichiri, Malawi.; sgraham@unima.wn.apc.org
- The conformation of purified Toxoplasma gondii SAG1 antigen, secreted from engineered Pichia pastoris, is adequate for serorecognition and cell proliferation.
- J Biotechnol. 1998 Dec 11;66(2-3):137-46. Unique Identifier : AIDSLINE MED/99084097
- Biemans R; Gregoire D; Haumont M; Bosseloir A; Garcia L; Jacquet A; Dubeaux C; Bollen A; Service de Genetique Appliquee, Universite Libre de; Bruxelles, Nivelles, Belgium. rbiemans@sga.ulb.ac.be
- A truncated form of SAG1, the immunodominant surface antigen of Toxoplasma gondii, has been produced in the methylotrophic yeast, Pichia pastoris. By construction, the recombinant protein lacks C-terminal residues 308-336 which, in native SAG1, encompass the glycosylphosphatidylinositol anchorage site. Secretion of an
- Vector development: a major obstacle in human gene therapy [editorial]
- Ann Med. 1998 Oct;30(5):413-5. Unique Identifier : AIDSLINE MED/99029963
- Jane SM; Cunningham JM; Vanin EF
- Gene therapy has been proposed for a wide variety of human conditions including monogenic disorders, such as the haemoglobinopathies and immunodeficiency syndromes, cancer and many other diseases. Prerequisites for the success of this approach include the ability to deliver the therapeutic gene intact to the target ce
- Human airway epithelial monolayers promote selective transmigration of memory T cells: a transepithelial model of lymphocyte migration into the airways.
- Am J Respir Cell Mol Biol. 1998 Dec;19(6):892-900. Unique Identifier : AIDSLINE MED/99061822
- Miller LA; Butcher EC; Department of Anatomy, Physiology, and Cell Biology, School of; Veterinary Medicine, University of California at Davis, Davis; 95616, USA. lmiller@ucdavis.edu
- It has previously been demonstrated that T lymphocytes in the conducting airways express a pattern of adhesion molecules that are uniquely different from T lymphocytes found circulating in peripheral blood. To examine the role of airway epithelia in the determination of migratory capacity for human monocyte and lympho
- Further evidence for hexagonal organization of HIV gag protein in prebudding assemblies and immature virus-like particles.
- J Struct Biol. 1998 Oct;123(2):143-9. Unique Identifier : AIDSLINE MED/99062209
- Nermut MV; Hockley DJ; Bron P; Thomas D; Zhang WH; Jones IM; National Institute for Biological Standards and Control, South; Mimms, Hertfordshire, EN6 3QG, U.K.
- The fullerene-like model for the organization of HIV gag encoded precursor pr55gag was based on the study of prebudding assemblies at the plasma membrane of cells infected with a recombinant baculovirus expressing HIV-1 gag protein. The objective of the present study was to support the model by image processing of vir
- PHS guidelines for the management of health-care worker exposures to HIV--Part 1.
- Oncology (Huntingt). 1998 Sep;12(9):1331-2, 1335-6, 1339 passim. Unique Identifier : AIDSLINE MED/98451702
- Epidemic Kaposi's sarcoma.
- Oncology (Huntingt). 1998 Sep;12(9):1375-81, 1385; discussion 1385-90. Unique Identifier : AIDSLINE MED/98451708
- Cianfrocca M; Roenn JH; Northwestern University Medical School, Division of; Hematology/Oncology, Chicago, Illinois, USA.
- Kaposi s sarcoma (KS) is the most common malignancy associated with human immunodeficiency virus-1 (HIV-1) infection and can result in significant morbidity. The clinical course of KS is quite variable, although for the majority of patients, KS is ultimately a progressive disease requiring systemic therapy. For early
- An achievable goal.
- Nurs Stand. 1998 Feb 4-10;12(20):18. Unique Identifier : AIDSLINE MED/98173640
- Youle M; Royal Free Hospital, London.
- Covalent immobilization of proteins onto (Maleic anhydride-alt-methyl vinyl ether) copolymers: enhanced immobilization of recombinant proteins.
- Bioconjug Chem. 1998 Nov-Dec;9(6):655-61. Unique Identifier : AIDSLINE MED/99034505
- Ladaviere C; Delair T; Domard A; Novelli-Rousseau A; Mandrand B; Mallet F; Unite Mixte UMR-103, CNRS-bioMerieux, ENS-Lyon, 46, allee; d'Italie, 69364 Lyon, France.
- Two genetically modified HIV-1 capsid p24 proteins, RH24 and RH24K, were covalently bound to maleic anhydride-alt-methyl vinyl ether (MAMVE) copolymer, under aqueous conditions. We demonstrated that the addition of a six lysine unit tag at the COOH-terminus of RH24K greatly improved the grafting reaction which could t
- Ruthenium red preserves glycoprotein peplomers of C-type retroviruses for transmission electron microscopy.
- Biotech Histochem. 1998 Jul;73(4):222-7. Unique Identifier : AIDSLINE MED/98405288
- Fassel TA; Raisch KP; Chetty N; Grossberg SE; Kushnaryov VM; Department of Microbiology, Medical College of Wisconsin,; Milwaukee 53226, USA.
- Peplomers, the glycoprotein projections of the outer viral envelope, are distinctive for many viruses. Peplomers of retroviral C-type particles are fragile and are not preserved in standard preparations for transmission electron microscopy of thin sections, whereas the peplomers of B- and D- type retroviruses are usua
- Human salivary histatins: promising anti-fungal therapeutic agents.
- Crit Rev Oral Biol Med. 1998;9(4):480-97. Unique Identifier : AIDSLINE MED/99042664
- Tsai H; Bobek LA; Department of Oral Biology, School of Dental Medicine, State; University of New York at Buffalo 14214, USA.
- Histatins constitute a group of small, cationic multifunctional proteins present in the saliva of human and some non-human primates. The most significant function of histatins may be their anti-fungal activity against Candida albicans and Cryptococcus neoformans. Histatins have been extensively studied at both the pro
- HIV infected women and genital health.
- Curr Opin Obstet Gynecol. 1998 Oct;10(5):375-8. Unique Identifier : AIDSLINE MED/99035621
- Barton SE; Chelsea and Westminster Hospital, London, UK.; sbarton@crusaidstar.co.uk
- The clinical benefits of the recent developments in antiretroviral therapy for HIV infected patients are changing both the presentation and prognosis of individuals with HIV infection, predominantly in the developed world. The genital health of women with HIV infection is an important area for study because of the unu
- Anti-D treatment for chronic immune thrombocytopenic purpura: clinical and laboratory aspects.
- Unique Identifier : AIDSLINE MED/99026699
- Sagripanti A; Ferretti A; Giannessi D; Carpi A; Bernini W; Ambrogi F; De Caterina R
- We used low-dose anti-D immunoglobulins for home treatment of Rh+ adult patients with chronic immune thrombocytopenic purpura (ITP). After informed consent, 15 unselected outpatients (ten males and five females, aged 22 to 72), affected by chronic ITP with negative HIV test, were given intramuscular injection of 900-1
- HIV/AIDS units: is there still a need? [editorial]
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):16-8. Unique Identifier : AIDSLINE MED/99022109
- Morrison C
- Barriers to self-care in a cohort of low-income white women living with HIV/AIDS.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):22-36. Unique Identifier : AIDSLINE MED/99022110
- Leenerts MH; Medical College of Georgia, Department of Community Nursing,; Augusta, USA.
- In this cohort of 12 low-income White women with HIV disease, five conditions at diagnosis emerged as barriers to self-care: (a) health care provider (HCP) failure to mobilize resources, (b) HCP devaluing of women, (c) social devaluing, (d) economic problems, and (e) legal problems. The core category, disconnection fr
- Census trends in AIDS specialty units.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):42-6. Unique Identifier : AIDSLINE MED/99022111
- Napper RL Jr; Johns Hopkins, Baltimore, Maryland, USA.
- As HIV disease evolves into a chronic and manageable disease, monitoring trends in HIV/AIDS inpatient use will become an important tool clinicians can use to analyze the need for organizational changes in patient care delivery. Monitoring census trends can assist nurses in developing plans of care and evaluating outco
- A symptom review: nausea and vomiting in HIV.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):47-56. Unique Identifier : AIDSLINE MED/99022112
- Capili B; Anastasi JK; Center for AIDS Research, Columbia University School of Nursing,; USA.
- Nausea and vomiting are symptoms often experienced by individuals with HIV disease. The etiologies are multifactorial, yet the symptoms have not been well studied in HIV research. Interventions currently used are adapted from the oncology setting and remain to be tested on patients with HIV. The purpose of this articl
- Health-related quality of life in HIV disease: achieving a balance.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):59-71. Unique Identifier : AIDSLINE MED/99022113
- Murdaugh C; College of Nursing, University of South Carolina, Columbia 29208,; USA. carolyn.murdaugh@sc.edu
- Using grounded theory methods, open-ended interviews were conducted with persons diagnosed with HIV disease to explore and describe how they adjust to living with their disease in relation to their health-related quality of life over the illness trajectory. A substantive theory was generated that describes the process
- HIV/AIDS risk in the college population: modifying the culture in a private religious university.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):72-9. Unique Identifier : AIDSLINE MED/99022114
- Sharts-Hopko NC; Bonas GH Jr; College of Nursing, Villanova University, PA 19085-1690, USA.; nshartsh@email.vill.edu
- From 1991 to the present, the AIDS Task Force in a private religious university has established a broad-based, multidisciplinary, multifaceted program aimed at reducing sexual risk taking as well as related behaviors. This has been accomplished at no cost to the university. The task force has focused on facilitating l
- Mandatory name reporting of HIV infection.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):80-1. Unique Identifier : AIDSLINE MED/99022115
- Bloomer S
- Bridging the gap: 12th World AIDS conference update.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):82-5. Unique Identifier : AIDSLINE MED/99022116
- Porche D; Willard S; Nursing Program, Nicholls State University, USA.
- Updated estimates of condom effectiveness.
- J Assoc Nurses AIDS Care. 1998 Nov-Dec;9(6):88-9. Unique Identifier : AIDSLINE MED/99022117
- Pinkerton SD; Abramson PR; Turk ME; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee, USA.
- Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/tandem mass spectrometry.
- Rapid Commun Mass Spectrom. 1998;12(22):1756-60. Unique Identifier : AIDSLINE MED/99070497
- Lopez LL; Yu X; Cui D; Davis MR; ThermoQuest Finnigan, San Jose, CA 95134, USA.
- A rapid and systematic strategy for the identification of drug metabolites in biological matrices based on liquid chromatography-tandem mass spectrometry (LC/MS/MS) techniques was utilized for the identification of drug metabolites of the HIV protease inhibitor
- Determination of the equilibrium micelle-inserting position of the fusion peptide of gp41 of human immunodeficiency virus type 1 at amino acid resolution by exchange broadening of amide proton resonances.
- J Biomol NMR. 1998 Nov;12(4):549-52. Unique Identifier : AIDSLINE MED/99079123
- Chang DK; Cheng SF; Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic; of China.
- The exchange broadening of backbone amide proton resonances of a 23-mer fusion peptide of the transmembrane subunit of HIV-1 envelope glycoprotein gp41, gp41-FP, was investigated at pH 5 and 7 at room temperature in perdeuterated sodium dodecyl sulfate (SDS) micellar solution. Comparison of resonance peaks for these p
- Characterization of a folding intermediate from HIV-1 ribonuclease H.
- Protein Sci. 1998 Oct;7(10):2164-74. Unique Identifier : AIDSLINE MED/99006568
- Kern G; Handel T; Marqusee S; Department of Molecular and Cell Biology, University of; California, Berkeley, 94720, USA.
- The RNase H domain from HIV-1 (HIV RNase H) encodes an essential retroviral activity. Refolding of the isolated HIV RNase H domain shows a kinetic intermediate detectable by stopped-flow far UV circular dichroism and pulse-labeling H/D exchange. In this intermediate, strands 1, 4, and 5 as well as helices A and D appe
- Solution structure and backbone dynamics of Mason-Pfizer monkey virus (MPMV) nucleocapsid protein.
- Protein Sci. 1998 Nov;7(11):2265-80. Unique Identifier : AIDSLINE MED/99043695
- Gao Y; Kaluarachchi K; Giedroc DP; Center for Macromolecular Design, Department of Biochemistry and; Biophysics, Texas A&M University, College Station 77843-2128,; USA.
- Retroviral nucleocapsid proteins (NCPs) are CCHC-type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation. Mason- Pfizer monkey virus (MPMV), a type D retrovirus, encodes a 96-amino acid nucleocap
- Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
- Protein Sci. 1998 Nov;7(11):2314-23. Unique Identifier : AIDSLINE MED/99043699
- Kervinen J; Lubkowski J; Zdanov A; Bhatt D; Dunn BM; Hui KY; Powell DJ; Kay J; Wlodawer A; Gustchina A; Macromolecular Structure Laboratory, ABL-Basic Research Program,; NCI-Frederick Cancer Research and Development Center, Maryland; 21702, USA.
- One of the major problems encountered in antiviral therapy against AIDS is the emergence of viral variants that exhibit drug resistance. The sequences of proteases (PRs) from related retroviruses sometimes include, at structurally equivalent positions, amino acids identical to those found in drug-resistant forms of HI
- The perception of discrimination in the HIV policy among Czech gay men.
- Cent Eur J Public Health. 1998 Aug;6(3):192-4. Unique Identifier : AIDSLINE MED/99004187
- Prochazka I; Weiss P; Institute of Sexuology, Charles University, 1st Medical Faculty,; Prague, Czech Republic.
- The study aimed to evaluate the perception of discrimination in the Czech national HIV policy among gay men. The anonymous questionnaires were published in the gay journal and 191 respondents filled them and returned back. Their assessment of discrimination in the HIV policy and other life activities were ranked in 5-
- Nutritional management of patients with AIDS-related anorexia.
- Semin Gastrointest Dis. 1998 Oct;9(4):189-99. Unique Identifier : AIDSLINE MED/99037875
- Kotler DP; St. Luke's-Roosevelt Hospital Center, College of Physicians and; Surgeons, Columbia University, New York, NY 10025, USA.
- Anorexia is a common problem in HIV infection and occurs via several mechanisms, including local pathology in the oral cavity or esophagus, central nervous system disease affecting eating mechanics or the perception of hunger, or secondary anorexia due to systemic infections, malabsorption, or medications, or to nonme
- Opportunistic infections of the central nervous system in the course of acquired immune deficiency syndrome (AIDS). Morphological analysis of 172 cases.
- Unique Identifier : AIDSLINE MED/99050584
- Zelman IB; Mossakowski MJ
- A neuropathological analysis of 172 cases of AIDS in adults was carried out, to determine the occurrence and nature of the opportunistic infections of the central nervous system (CNS). The material comprised 155 cases of men, and 17 women. Mean age of patients was 38 years. Collection under study originated from the p
- The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments [see comments]
- Subst Use Misuse. 1998 Sep;33(11):2323-51. Unique Identifier : AIDSLINE MED/98428983
- Bourgois P; Department of Epidemiology and Biostatistics, University of; California, San Francisco, 94143, USA. bourgois@sfsu.edu
- Ethnographic immersion among homeless heroin addicts in San Francisco documents far more risky practices than the public health literature routinely reports. The logics of street-based income-generating strategies and the moral economy of social networking among self-identified dope fiends results in almost daily sh
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois [comment]
- Subst Use Misuse. 1998 Sep;33(11):2353-5. Unique Identifier : AIDSLINE MED/98428984
- Courtwright DT; Department of History, University of North Florida, Jacksonville; 32224-2645, USA. dcourtwr@unf.edu
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois [comment]
- Subst Use Misuse. 1998 Sep;33(11):2357-9. Unique Identifier : AIDSLINE MED/98428985
- Lilja J; Hamilton D; Larsson S; Department of Pharmacy, Abo Akademi, Turku, Finland.
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois [comment]
- Subst Use Misuse. 1998 Sep;33(11):2361-3. Unique Identifier : AIDSLINE MED/98428986
- Fielding NG; Department of Sociology, University of Surrey, Guildford,; England.
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois [comment]
- Subst Use Misuse. 1998 Sep;33(11):2365-8. Unique Identifier : AIDSLINE MED/98428987
- Johnson TP; Survey Research Laboratory, University of Illinois at Chicago,; 60607, USA. tjohnson@srl.uic.edu
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois.
- Subst Use Misuse. 1998 Sep;33(11):2369-74. Unique Identifier : AIDSLINE MED/98428988
- Leshner AI; National Institute on Drug Abuse, Rockville, Maryland 20857, USA.
- Comments on "The moral economies of homeless heroin addicts: confronting ethnography, HIV risk, and everyday violence in San Francisco shooting encampments," by Phillippe Bourgois.
- Subst Use Misuse. 1998 Sep;33(11):2375-82. Unique Identifier : AIDSLINE MED/98428989
- Latkin CA; Department of Health Policy & Management, The Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA. clatkin@jhsph.edu
- Characterization of B16 melanoma-specific cytotoxic T lymphocytes.
- Cancer Immunol Immunother. 1998 Dec;47(4):198-204. Unique Identifier : AIDSLINE MED/99090850
- Harada M; Tamada K; Abe K; Li T; Onoe Y; Tada H; Tatsugami K; Ando T; Kimura G; Nomoto K; Department of Virology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan. haradam@pop.nci.nih.gov
- A B16 melanoma-specific CD8+ T cell line (AB1) was established from the spleen cells of C57BL/6 mice cured of B16 melanoma with interleukin (IL)-12 treatment. The AB1 line exclusively used T cell receptor Vbeta11. The AB1 cells exhibited a cytolytic activity against both syngeneic B16 melanoma and allogeneic P815 mast
- Hemodynamics of cardiac tamponade in a patient with AIDS-related non-Hodgkin's lymphoma.
- Cathet Cardiovasc Diagn. 1998 Nov;45(3):287-91. Unique Identifier : AIDSLINE MED/99045354
- Azrak EC; Kern MJ; Bach RG; Department of Internal Medicine, Saint Louis University Hospital,; Missouri 63110, USA.
- Although cardiac involvement has been commonly described in HIV-infected patients, cardiac tamponade is an unusual feature of AIDS-related non-Hodgkin s lymphoma . We describe an AIDS patient with undiagnosed non-Hodgkin s lymphoma presenting with hemodynamics of pericardial tampona
- Small bowel review: Part I.
- Can J Gastroenterol. 1998 Oct;12(7):487-504. Unique Identifier : AIDSLINE MED/99028702
- Thomson AB; Hasan J; Keelan M; Wild G; Department of Medicine, University of Alberta, Edmonton.; alan.thomson@ualberta.ca
- In the past year there have been many advances in the area of small bowel physiology and pathology. In preparation for this review, over 500 papers were assessed, and some have been selected and reviewed, with a particular focus on presenting clinically useful information for the practising gastroenterologist.
- Depression in cancer and HIV infection: research findings and implications of effective antidepressant treatment.
- Depress Anxiety. 1998;8 Suppl 1:80-4. Unique Identifier : AIDSLINE MED/99026746
- Petitto JM; Evans DL; Department of Psychiatry, University of Florida College of; Medicine, Gainesville 32610-0256, USA.
- Rethinking about the role of antiretroviral regimens for HIV-related chronic diarrhoea [letter]
- Ital J Gastroenterol Hepatol. 1998 Aug;30(4):445-6. Unique Identifier : AIDSLINE MED/99005580
- Famularo G; De Simone C
- HIV infection in dialysis centers in Italy: a nationwide multicenter study.
- J Nephrol. 1998 Sep-Oct;11(5):249-54. Unique Identifier : AIDSLINE MED/99047123
- Barbiano di Belgiojoso G; Trezzi M; Scorza D; Barone MT; Landriani N; Genderini A; Bertoli S; Nephrology and Dialysis Unit, L. Sacco University Hospital,; Milano, Italy.
- The prevalence of HIV infection in dialysis populations varies according to different countries and geographic areas. We performed a nationwide epidemiological study by means of a questionnaire in the period from January 1990 to December 1995. Questions were about whether and which HIV tests were performed and which p
- Subchronic toxicity of human immunodeficiency virus and tuberculosis combination therapies in B6C3F1 mice.
- Toxicol Sci. 1998 Sep;45(1):113-27. Unique Identifier : AIDSLINE MED/99064584
- Rao GN; Lindamood C 3rd; Heath JE; Farnell DR; Giles HD; National Institute of Environmental Health Sciences, North; Carolina 27709, USA.
- Combination therapy with anti-HIV drugs and opportunistic infection drugs is a common practice in treatment of AIDS patients. Although toxic effects of most individual therapies are known, the toxic potential of most combination therapies has not been established. To understand the toxic consequences of combination th
- Caring theory: a framework for advanced practice nursing.
- Adv Pract Nurs Q. 1998 Summer;4(1):70-7. Unique Identifier : AIDSLINE MED/99092099
- Nelson-Marten P; Hecomovich K; Pangle M; Oncology Nursing, School of Nursing, University of Colorado,; Denver, USA.
- This article provides a brief review of Watson s theory of caring and demonstrates its usefulness as a framework for advanced practice nursing. Two case studies, a recently diagnosed patient who is positive for the human immunodeficiency virus and a patient terminally ill with acquired immunodeficiency syndrome, are r
- Guess What! Localised bacillary angiomatosis of the tongue.
- Eur J Dermatol. 1998 Jun;8(4):283-4. Unique Identifier : AIDSLINE MED/99109954
- Calista D; Boschini A; Giangaspero F; Department of Dermatology, Ospedale "M. Bufalini", 47023 Cesena,; Italy.
- Porphyria cutanea tarda associated with human immunodeficiency virus infection.
- Eur J Dermatol. 1998 Oct-Nov;8(7):492-6. Unique Identifier : AIDSLINE MED/99072941
- Drobacheff C; Derancourt C; Van Landuyt H; Devred D; de Wazieres B; Cribier B; Rey D; Lang JM; Grosieux C; Kalis B; Laurent R; Department of Dermatology, Besancon University Hospital, 25030; Besancon Cedex, France.
- Since 1987, about 60 cases of porphyria cutanea tarda (PCT) associated with human immunodeficiency virus (HIV) have been reported. The respective roles of HIV and toxic hepatic factor in PCT remain unclear. We report 10 new cases and analyse the following toxic hepatic factors: hepatitis C and B, alcoholism, drugs. Th
- NMR structure determination of proteins and protein complexes larger than 20 kDa.
- Curr Opin Chem Biol. 1998 Oct;2(5):564-70. Unique Identifier : AIDSLINE MED/99035569
- Clore GM; Gronenborn AM; Laboratory of Chemical Physics, National Institute of Diabetes; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0520, USA.
- Recent advances in multidimensional nuclear magnetic resonance methodology to obtain 1H, 15N and 13C resonance assignments, interproton distance and torsion angle restraints, and restraints that characterize long-range order, coupled with new methods of structure refinement and novel methods for reducing linewidths, h
- [Human immunodeficiency virus and resistance]
- Rev Esp Quimioter. 1998 Jun;11(2):152-6. Unique Identifier : AIDSLINE MED/99062079
- Coordoba J; Otero MC; Lainez B; Perez-Tamarit D; Molina JM; Calvo MA; Asensi F; Gobernado M; Servicio de Microbiologia, Hospital La Fe, Valencia.
- It has been demonstrated that following prolonged treatment with reverse transcriptase inhibitors, especially with nucleoside analogs, resistant viral strains appear that show mutations in the nucleotides of the gene that codifies reverse transcriptase. These mutations cause changes in amino acids, which gradually inc
- Etiology and pathogenesis of posttransplant tumors: new insights into viral oncogenesis.
- Ann Transplant. 1997;2(4):67-9. Unique Identifier : AIDSLINE MED/99086705
- el-Sabrout R; Gruber SA; Department of Surgery, University of Texas at Houston Health; Science Center, USA.
- Kaposi's sarcoma.
- Ann Transplant. 1998;3(1):5-12. Unique Identifier : AIDSLINE MED/99086715
- Schwartz RA; New Jersey Medical School, USA.
- Kaposi s sarcoma is an unusual neoplasm that is seen with increased incidence in transplant recipients. Its occurrence in this group as a tumor is noteworthy in that it may regress spontaneously if immunosuppression is reduced or discontinued. Thus, its response in this setting raises the question of whether it might
- Safety of coagulation factor concentrates.
- Haemophilia. 1998 Jul;4(4):393-401. Unique Identifier : AIDSLINE MED/99090446
- Teitel JM; St. Michael's Hospital, Toronto, Ontario, Canada.; Teitelj@smh.toronto.on.ca
- Many of the adverse effects of the early crude plasma-derived concentrates were ameliorated by increasing their purity. Ironically, this strategy may have increased the risks of inhibitor formation and pathogen transmission due to the addition of processing steps which can alter the immunogenicity of clotting factors
- Assessment and treatment of liver disease in Japanese haemophilia patients.
- Haemophilia. 1998 Jul;4(4):595-600. Unique Identifier : AIDSLINE MED/99090486
- Fukuda Y; Nakano I; Katano Y; Toyoda H; Imoto M; Takamatsu J; Saito H; Hayakawa T; Second Department of Internal Medicine, Nagoya University School; of Medicine, Japan. yfukuda@tsuru.med.nagoyau.ac.jp
- We studied the prevalence of the hepatitis C virus (HCV), human immunodeficiency virus (HIV) and GB virus C or hepatitis G virus (GBV-C/HGV), and characteristics of infections in Japanese haemophilia patients. Haemophilia patients were highly infected with HCV (88.2%) because of frequent use of unheated blood concentr
- Progression of HIV in haemophilia.
- Haemophilia. 1998 Jul;4(4):601-9. Unique Identifier : AIDSLINE MED/99090487
- Ragni MV; University of Pittsburgh School of Medicine, PA 15213-4306, USA.; ragni@edison.isd.upmc.edu
- The recent elucidation of the life cycle and dynamics of the human immunodeficiency virus (HIV) and technological advances in development of the HIV RNA PCR assay for sensitive detection of viral load have revolutionized the diagnosis, management, and treatment of HIV infection. Beginning with initial infection, there
- Resistance to HIV protease inhibitors.
- Haemophilia. 1998 Jul;4(4):610-5. Unique Identifier : AIDSLINE MED/99090488
- Condra JH; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19486, USA. jon_condra@merck.com
- Resistance to the HIV-1 protease inhibitor indinavir involves the accumulation of multiple amino acid substitutions in the viral protease. A minimum of 11 amino acid positions have been identified as potential contributors to phenotypic resistance. Th
- HIV treatment--a rational approach to the use of antiretroviral agents.
- Haemophilia. 1998 Jul;4(4):616-8. Unique Identifier : AIDSLINE MED/99090489
- Vella S; Retrovirus Department, Istituto Superiore di Sanita, Rome,; Italy. stefanovella@interbusiness.it
- Over the last 2 years, advances in many areas of HIV clinical research and data on the effectiveness of potent combination therapy have substantially influenced the overall perspective of long-term management of HIV disease. However, the progress against HIV also came
- HIV epidemic in Punjab, India: time trends over a decade.
- Bull World Health Organ. 1998;76(5):509-13. Unique Identifier : AIDSLINE MED/99085733
- Sehgal S; Department of Immunopathology, Postgraduate Institute of Medical; Education and Research, Chandigarh, India.
- Although Bombay (Mumbai) appears to be the main focus for acquired immunodeficiency syndrome (AIDS) in India , rapid spread has occurred through other major cities as well. The first AIDS patient in the northern state of Punjab was reported in May 1987. The present study, spanning a
- Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.
- Carcinogenesis. 1998 Dec;19(12):2133-8. Unique Identifier : AIDSLINE MED/99101659
- Chi WJ; Doong SL; Lin-Shiau SY; Boone CW; Kelloff GJ; Lin JK; Institute of Biochemistry, College of Medicine, National Taiwan; University, No. 1, Section 1, Taipei.
- Molecular epidemiological studies of populations at high risk for liver cancer have shown that hepatitis B virus (HBV) and aflatoxin B1 exposures are two major risk factors for this disease. Oltipraz is currently being considered for clinical trial to protect against aflatoxin B1-induced hepatocarcinogenesis based on
- CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.
- Unique Identifier : AIDSLINE MED/99057808
- Mann RA; Schiff D; Jetzt AE; Ron Y; Singh M; Singh AB
- Murine graft-versus-host (GVH) disease takes two forms depending upon the parental/F1 strain combination employed. Anemia, lymphopenia, hypogammaglobulinemia, profound anti-F1 cytotoxicity, and the loss of cytotoxic potential against third party alloantigen is seen in acute lethal GVH disease. In contrast to this, in
- Indicators of T-cell activation: correlation between quantitative CD38 expression and soluble CD8 levels in asymptomatic HIV+ individuals and healthy controls.
- Cytometry. 1998 Oct 1;33(2):115-22. Unique Identifier : AIDSLINE MED/98444855
- Lenkei R; Bratt G; Holmberg V; Muirhead K; Sandstrom E; CALAB Research, S:t. Gorans Hospital, Stockholm, Sweden.; rodica.lenkei@calab.se
- Increased activation of CD8+ T cells, particularly increased expression of CD38 antigen, has been shown to strongly correlate with progression of human immunodeficiency virus-positive (HIV+) individuals to acquired immunodeficiency syndrome (AIDS) and death. As part of a study evaluating responses to a recombinant gp1
- Quantitation of CD38 activation antigen expression on CD8+ T cells in HIV-1 infection using CD4 expression on CD4+ T lymphocytes as a biological calibrator.
- Cytometry. 1998 Oct 1;33(2):123-32. Unique Identifier : AIDSLINE MED/98444856
- Hultin LE; Matud JL; Giorgi JV; The Multicenter AIDS Cohort Study and UCLA School of Medicine,; Los Angeles, California 90095-1745, USA. hultinl@mednet.ucla.edu
- For some membrane-associated antigens, the number of molecules expressed per cell carries information about the cell s differentiation and activation state. Quantitating antigen expression by flow cytometry has immediate application in monitoring CD38 expression on CD8+ T cells in human immunodeficiency virus 1-associ
- CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression.
- Cytometry. 1998 Oct 1;33(2):133-7. Unique Identifier : AIDSLINE MED/98444857
- Perfetto SP; Malone JD; Hawkes C; McCrary G; August B; Zhou S; Garner R; Dolan MJ; Brown AE; Henry M. Jackson Foundation, Rockville, Maryland, USA.
- Previous studies have revealed that the expression of CD38 on CD8+ T cells is a strong predictor of disease progression in human immunodeficiency virus (HIV)-infected individuals. Those studies were performed using fresh patient samples over an extended trial period. After demonstrating the validity of assay results o
- Impact of unified procedures as implemented in the Canadian Quality Assurance Program for T lymphocyte subset enumeration. Participating Flow Cytometry Laboratories of the Canadian Clinical Trials Network for HIV/AIDS Therapies.
- Cytometry. 1998 Oct 1;33(2):146-55. Unique Identifier : AIDSLINE MED/98444859
- Bergeron M; Faucher S; Minkus T; Lacroix F; Ding T; Phaneuf S; Somorjai R; Summers R; Mandy F; National Laboratory for Analytical Cytology, Bureau of HIV/AIDS,; Health Canada, Ottawa, Ontario.
- The objective of the Canadian Quality Assurance Program (CQAP) is to provide the most reproducible and accurate T-cell subset enumeration for individuals living with HIV who are enrolled in the Canadian Clinical Trial Network for Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) Therapi
- Quantitation of CD38 expression using QuantiBRITE beads.
- Cytometry. 1998 Oct 1;33(2):206-12. Unique Identifier : AIDSLINE MED/98444865
- Iyer SB; Hultin LE; Zawadzki JA; Davis KA; Giorgi JV; Becton Dickinson Immunocytometry Systems, San Jose, California,; USA. sujata_iyer@bdis.com
- The QuantiBRITE bead method was compared with the CD4 biological calibration method for quantitation of CD38 expression on CD8+ T-lymphocytes of Multicenter AIDS Cohort Study participants. Results were expressed as CD38 antibodies bound per cell (ABCs) and were the same with the two methods provided two conditions wer
- T-lymphocyte functionality assessed by analysis of cytokine receptor expression, intracellular cytokine expression, and femtomolar detection of cytokine secretion by quantitative flow cytometry.
- Cytometry. 1998 Oct 1;33(2):249-55. Unique Identifier : AIDSLINE MED/98444871
- Collins DP; Luebering BJ; Shaut DM; BioErgonomics, Inc., White Bear Lake, Minnesota 55127, USA.; dc@bioe.com
- Assessing the functionality of T lymphocytes is important in determining progression rate in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), transplant rejection, and autoimmune disease. Activation of T-cells in response to antigen results in expression of cytokines and cyto
- [HIV drugs: no solution for psychosocial problems (news)]
- Dtsch Med Wochenschr. 1998 Dec 18;123(51-52):A12. Unique Identifier : AIDSLINE MED/99109556
- Weismann H
- Unusual clinical presentation of infection due to Flavimonas oryzihabitans.
- Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):645-8. Unique Identifier : AIDSLINE MED/99049107
- Giacometti A; Cirioni O; Quarta M; Schimizzi AM; Del Prete MS; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Azienda Ospedaliera Umberto I, Italy.
- Six cases of Flavimonas oryzihabitans infection are presented, four of which were community-acquired pneumonia and two of which were nosocomially acquired bacteremia. All four cases of pneumonia occurred in immunosuppressed hosts, three of whom were HIV-positive individuals and one of whom was a young man affected by
- Fatal mediastinal lymph node drainage into the airways of two patients with human immunodeficiency virus-related tuberculosis.
- Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):670-1. Unique Identifier : AIDSLINE MED/99049113
- Lopez-Suarez A; Bascunana A; Elvira J; Garcia-del-Rio E; Escribano JC; Giron JA; Infectious Diseases Unit, Internal Medicine Service, Puerta del; Mar University Hospital, Cadiz, Spain.
- Bordetella bronchiseptica cavitary pneumonia in a patient with AIDS.
- Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):675-6. Unique Identifier : AIDSLINE MED/99049116
- Garcia San Miguel L; Quereda C; Martinez M; Martin-Davila P; Cobo J; Guerrero A; Department of Infectious Diseases and Microbiology, Hospital; Ramon y Cajal, Madrid, Spain.
- Accessibility of selenomethionine proteins by total chemical synthesis: structural studies of human herpesvirus-8 MIP-II.
- FEBS Lett. 1998 Dec 11;441(1):77-82. Unique Identifier : AIDSLINE MED/99092996
- Shao W; Fernandez E; Wilken J; Thompson DA; Siani MA; West J; Lolis E; Schweitzer BI; Walt Disney Memorial Cancer Institute at Florida Hospital,; Orlando 32826, USA.
- The determination of high resolution three-dimensional structures by X-ray crystallography or nuclear magnetic resonance (NMR) is a time-consuming process. Here we describe an approach to circumvent the cloning and expression of a recombinant protein as well as screening for heavy atom derivatives. The selenomethionin
- HIV-1 and the developing central nervous system.
- Dev Med Child Neurol. 1998 Dec;40(12):843-6. Unique Identifier : AIDSLINE MED/99096009
- Tardieu M; Universites-Praticien Hospitalier, Departement de Pediatrie,; Hopital Bicetre et Laboratoire 'Virus, Neurone' et Immunite; INSERM, Le Kremlin-Bicetre, France.
- [Numerical analysis of western blot digitalized images. The case of HIV]
- Gac Med Mex. 1998 Jul-Aug;134(4):385-96. Unique Identifier : AIDSLINE MED/99005812
- Larralde C; Paz E; Viveros M; Padilla A; Soler C; Govezensky T; Instituto de Investigaciones Biomedicas, UNAM, Mexico D.F.,; Mexico.
- The present work explores the use of image digitalization of western blot (WB) aiming to extract more information about the humoral immune response of human immunodeficiency virus (HIV) infected individuals, and to analyze obtained data in a multivariate manner. The digitalization and analysis of WB images was perform
- Mitochondria as cell targets of AZT (zidovudine).
- Gen Pharmacol. 1998 Oct;31(4):531-8. Unique Identifier : AIDSLINE MED/99006697
- Barile M; Valenti D; Quagliariello E; Passarella S; Dipartimento di Biochimica e Biologia Molecolare, Universita; degli Studi di Bari, and Centro di Studio sui Mitocondri e; Metabolismo Energitico C.N.R., Italy. m.barile@biologia.uniba.it
- 1. The subject of this review is the interaction between AZT (zidovudine) and mitochondria as described in papers dealing with AZT therapy both in AIDS patients and in model systems--that is, in cultured cells and in isolated mitochondria. 2. The stru
- The regional integration of retroviral sequences into the mosaic genomes of mammals.
- Gene. 1998 Nov 5;222(1):1-16. Unique Identifier : AIDSLINE MED/99032995
- Rynditch AV; Zoubak S; Tsyba L; Tryapitsina-Guley N; Bernardi G; Laboratoire de Genetique Moleculaire, Institut Jacques Monod,; 2 Place Jussieu, 75005, Paris, France.
- We have reviewed here three sets of data concerning the integration of retroviral sequences in the mammalian genome: (i) our experimental localization of a number of proviruses integrated in isochores characterized by different GC levels; (ii) results from other laboratories on the localization of retroviral sequences
- In vitro growth on different cell lines of four microsporidial species infecting humans.
- Folia Parasitol (Praha). 1998;45(4):329-31. Unique Identifier : AIDSLINE MED/99085686
- Ludovisi A; Rossi P; Onori AM; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.
- Attitudes, beliefs, and practices of nursing students concerning HIV/AIDS: implications for prevention in women.
- Health Care Women Int. 1998 Jul-Aug;19(4):327-42. Unique Identifier : AIDSLINE MED/99089978
- Zimmer JC; Thurston WE; Conjoint Nursing Program, Mount Royal College, Calgary, Alberta,; Canada.
- Nursing students are a group of predominantly young women who may be sexually active but who are well educated and presumably health conscious. It might be expected, therefore, that they are not a population at risk for sexually acquired HIV infection. Recent studies indicate that heterosexual women constitute the fas
- Bartonella infections: diverse and elusive.
- Hosp Pract (Off Ed). 1998 Dec 15;33(12):37-8, 41-4, 49. Unique Identifier : AIDSLINE MED/99083878
- Loutit JS; Department of Medicine, Stanford University School of Medicine,; Calif., USA.
- Children with young cats, HIV-infected patients with low CD4 counts, and lice-infested homeless people are among those with an increased risk. Clinical presentation varies with the infecting Bartonella species and the host. Treatment for cat-scratch disease is supportive; macrolide therapy is an appropriate choice for
- Primary care of HIV infection.
- Hosp Pract (Off Ed). 1998 Dec 15;33(12):53-6, 61-4, 67-9, discussion; 69-71. Unique Identifier : AIDSLINE MED/99083879
- Bartlett JA; Sexton DJ; Department of Medicine, Duke University School of Medicine,; Durham, N.C., USA.
- Four cases illustrate some of the issues involved in treating HIV-infected patients in a primary care setting. Primary care physicians are hard-pressed to achieve the same results as infectious disease specialists, yet are increasingly responsible for performing the initial tests, choosing the therapeutic regimen, ens
- Administration of thymocytes derived from non-pregnant mice induces an endometrial receptive stage and leukaemia inhibitory factor expression in the uterus.
- Hum Reprod. 1998 Oct;13(1O):2888-94. Unique Identifier : AIDSLINE MED/99019396
- Fujita K; Nakayama T; Takabatake K; Higuchi T; Fujita J; Maeda M; Fujiwara H; Mori T; Department of Gynecology and Obstetrics, Faculty of Medicine,; Kyoto University, Japan.
- We have previously reported that intravenous administration of splenocytes prepared from mice in the early stages of pregnancy promoted embryo implantation in pseudopregnant mice. Since a T-lymphocyte-rich, but not a monocyte-rich preparation from splenocytes enhanced embryo implantation, similar effects of thymocytes
- Intraepithelial leukocytes in endometriosis and adenomyosis: comparison of eutopic and ectopic endometrium with normal endometrium.
- Hum Reprod. 1998 Oct;13(1O):2910-5. Unique Identifier : AIDSLINE MED/99019399
- Bulmer JN; Jones RK; Searle RF; Department of Pathology, University of Newcastle, Newcastle upon; Tyne, The Medical School, UK.
- Intraepithelial leukocytes (IEL) are recognized as an important component of most mucosal surfaces but have received scant attention in the human female reproductive tract. The aim of the present study was to characterize, quantify and compare IEL populations in normal endometrium (n = 30) and in eutopic and ectopic (
- Evaluation of an innovative program to address the health and social service needs of drug-using women with or at risk for HIV infection.
- J Community Health. 1998 Dec;23(6):419-40. Unique Identifier : AIDSLINE MED/99042233
- Thompson AS; Blankenship KM; Selwyn PA; Khoshnood K; Lopez M; Balacos K; Altice FL; Yale University School of Medicine, New Haven, Connecticut; 06510-2483, USA.
- Drug-using women with or at risk for HIV infection have many competing unmet needs, especially for social services, drug treatment, and medical care. High-risk drug-using women were recruited through street outreach, at needle exchange sites, a prison, and local community based organizations in New Haven, Connecticut
- "A grief observed": the experience of HIV-related illness and death among women in a clinic-based sample in New Haven, Connecticut.
- J Consult Clin Psychol. 1998 Dec;66(6):958-66. Unique Identifier : AIDSLINE MED/99092068
- Ickovics JR; Druley JA; Morrill AC; Grigorenko E; Rodin J; Department of Epidemiology and Public Health, Yale University; School of Medicine, New Haven, Connecticut 06520-8034, USA.; Jeannette.Ickovics@yale.edu
- This study examined how women in a clinic-based sample in New Haven, Connecticut, (N = 168), have been affected by the AIDS epidemic. The aims of this study were to (a) document the proportion of women who knew individuals who were HIV positive, who were symptomatic with AIDS, or who had died from AIDS; (b) compare th
- Psychosocial factors associated with the stages of change for condom use among women at risk for HIV and STDs: implications for intervention development.
- J Consult Clin Psychol. 1998 Dec;66(6):967-78. Unique Identifier : AIDSLINE MED/99092069
- Stark MJ; Tesselaar HM; O'Connell AA; Person B; Galavotti C; Cohen A; Walls C; Multnomah County Health Department, Portland, Oregon, USA.; mike.j.stark@state.or.us
- This study examined the prevalence of consistent condom use among inner-city women at risk for HIV, measured the distribution of these women across the stages of change for condom use, determined psychosocial factors associated with the stages, and suggested intervention strategies based on the results. The 5-city sam
- Cognitive processing, discovery of meaning, CD4 decline, and AIDS-related mortality among bereaved HIV-seropositive men.
- J Consult Clin Psychol. 1998 Dec;66(6):979-86. Unique Identifier : AIDSLINE MED/99092070
- Bower JE; Kemeny ME; Taylor SE; Fahey JL; Department of Psychology, University of California, Los Angeles,; USA. jbower@ucla.edu
- This study investigated whether finding meaning in response to an HIV-related stressor was associated with changes in immune status and health. Forty HIV-seropositive men who had recently experienced an AIDS-related bereavement completed interviews assessing cognitive processing and finding meaning after the loss and
- Six-hour trimethoprim-sulfamethoxazole-graded challenge in HIV-infected patients.
- J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):1033-6. Unique Identifier : AIDSLINE MED/99094942
- Demoly P; Messaad D; Sahla H; Fabre J; Faucherre V; Andre P; Reynes J; Godard P; Bousquet J; Maladies Respiratoires, Hopital Arnaud de Villeneuve,; Montpellier; Maladies Infectieuses et Tropicales, Hopital Guy de; Chauliac, Montpellier, France.
- BACKGROUND: Hypersensitivity reactions to trimethoprim-sulfamethoxazole (TMP-SMX) are very common in HIV-infected patients, leading to drug discontinuation. However, it is the drug of choice as prophylaxis for Pneumocystis carinii pneumonia. OBJECTIVES: We sought to determine the safety and long-term efficacy of a 6-h
- Molecular modulation of allergic responses.
- J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):887-92. Unique Identifier : AIDSLINE MED/99094922
- Huang SK; Johns Hopkins Asthma and Allergy Center, Department of Medicine; and Graduate Program in Cellular and Molecular Medicine, Johns; Hopkins University School of Medicine, Baltimore, MD, USA.
- The pathophysiology of allergic diseases involves an intricate network of molecular and cellular interactions. Elevated levels of serum IgE- and TH2 cytokine-associated eosinophilic inflammation characterize allergic diseases and provide potential targets for immunomodulation. Recent evidence that antigen-induced alle
- T lymphocytes that infiltrate nasal polyps have a specialized phenotype and produce a mixed TH1/TH2 pattern of cytokines.
- J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):953-60. Unique Identifier : AIDSLINE MED/99094932
- Sanchez-Segura A; Brieva JA; Rodriguez C; Servicio de Otorrinolaringologia, Hospital de Jerez, Cadiz; and; Servicio de Inmunologia, Hospital Universitario Puerta del Mar.
- BACKGROUND: Nasal polyps (NPs) are inflammatory reactions in the nasal mucosa the etiology and pathogenesis of which remains unknown. OBJECTIVE: The purpose of this study was to study in detail the phenotype and function of T lymphocytes infiltrating NPs by analyzing the expression of surface markers and cytokine secr
- Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2-primed mice.
- J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):961-7. Unique Identifier : AIDSLINE MED/99094933
- Hirahara K; Saito S; Serizawa N; Sasaki R; Sakaguchi M; Inouye S; Taniguchi Y; Kaminogawa S; Shiraishi A; Sankyo Co, Ltd, Tokyo.
- BACKGROUND: Oral immunotherapy with a peptide for allergic immune responses is theoretically a promising therapy but has not been established yet. OBJECTIVE: To evaluate immune suppressive efficacy of oral administration of an immunodominant peptide, we investigated changes in T-cell proliferation, TH1 - and TH2 cytok
- Institutional liability for needlestick injury [letter]
- Infect Control Hosp Epidemiol. 1998 Oct;19(10):737. Unique Identifier : AIDSLINE MED/99015894
- Tereskerz PM; Pearson RD; Jagger J
- Does clinical experience affect medical students' knowledge, attitudes, and compliance with universal precautions?
- Infect Control Hosp Epidemiol. 1998 Oct;19(10):767-71. Unique Identifier : AIDSLINE MED/99015904
- Jeffe DB; Mutha S; Kim LE; Evanoff BA; L'Ecuyer PB; Fraser VJ; Washington University School of Medicine, St Louis, MO, USA.; djeffe@imgate.wustl.edu
- OBJECTIVE: To investigate differences in second-, third-, and fourth-year medical students knowledge of bloodborne pathogen exposure risks, as well as their attitudes toward, and intentions to comply with, Universal Precautions (UP). DESIGN: Cross-sectional survey. PARTICIPANTS AND SETTING: Surveys about students kn
- Mycobacterium avium complex common-source or cross-infection in AIDS patients attending the same day-care facility.
- Infect Control Hosp Epidemiol. 1998 Oct;19(10):784-6. Unique Identifier : AIDSLINE MED/99015908
- Carbonne A; Lemaitre N; Bochet M; Truffot-Pernot C; Katlama C; Grosset J; Bricaire F; Jarlier V; Laboratoire de Bacteriologie, Hopital Pitie-Salpetriere,; Paris, France.
- To delineate the epidemiology of Mycobacterium avium complex (MAC) infection in acquired immunodeficiency syndrome patients, we studied 32 case patients with disseminated MAC infection who attended the same daycare facility during a period of 13 months. Pulsed-field gel electrophoresis analysis showed very low similar
- A single specific amino acid residue in peptide antigens is sufficient to activate memory CTL: potential role of cross-reactive peptides in memory T cell maintenance.
- J Immunol. 1999 Jan 1;162(1):106-13. Unique Identifier : AIDSLINE MED/99101466
- Reali E; Guerrini R; Marastoni M; Tomatis R; Masucci MG; Traniello S; Gavioli R; Department of Biochemistry and Molecular Biology, University of; Ferrara, Italy. reali.eva@hsr.it
- In the present study, we examined the structural requirements of peptide Ags for productive interactions with the TCR of CTL. For this purpose, we used as a model a previously identified immunodominant epitope that represents the target of EBV-specific HLA-A11-restricted CTL responses. By the use of peptides having mi
- Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin.
- J Immunol. 1999 Jan 1;162(1):114-21. Unique Identifier : AIDSLINE MED/99101467
- Marinaro M; Boyaka PN; Jackson RJ; Finkelman FD; Kiyono H; Jirillo E; McGhee JR; Department of Microbiology, Immunobiology Vaccine Center,; University of Alabama Medical Center, Birmingham 35294-2170, USA.
- We have investigated the effects of IL-12 and cholera toxin (CT) on the immune response to tetanus toxoid (TT) given by intranasal or oral routes. CT inhibited IL-12-induced IFN-gamma secretion both in vivo and in vitro. Intranasal administration of IL-12 to mice nasally immunized with the combined vaccine of TT and C
- Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.
- J Immunol. 1999 Jan 1;162(1):152-60. Unique Identifier : AIDSLINE MED/99101472
- van der Burg SH; Kwappenberg KM; Geluk A; van der Kruk M; Pontesilli O; Hovenkamp E; Franken KL; van Meijgaarden KE; Drijfhout JW; Ottenhoff TH; Melief CJ; Offringa R; Department of Immunohematology and Blood Bank, Leiden University; Medical Center, The Netherlands. shvdburg@worldonline.nl
- CD4+ Th cells play an important role in the induction and maintenance of specific T cell immunity. Indications for a protective role of CD4+ T cells against HIV-1 infection were found in subjects who were able to control HIV-1 viremia as well as in highly HIV-1-exposed, yet seronegative, individuals. This study descri
- Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets.
- J Immunol. 1999 Jan 1;162(1):209-14. Unique Identifier : AIDSLINE MED/99101479
- Erard F; Garcia-Sanz JA; Moriggl R; Wild MT; Laboratoire d'Immunologie, Institut de Recherches Cliniques de; Montreal, Canada. erardf@ircm.umontreal.ca
- CD8+ T cells often differentiate into highly cytotoxic cells, secreting a Th1-like or type 1 cytokine pattern characterized by the production of IFN-gamma. However, cytotoxic, and in some reports, noncytotoxic, type 2 cells that secrete IL-4, IL-5, or IL-10 instead of IFN-gamma, can be generated when CD8+ T cells are
- IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement.
- J Immunol. 1999 Jan 1;162(1):238-44. Unique Identifier : AIDSLINE MED/99101482
- Schmidt-Weber CB; Alexander SI; Henault LE; James L; Lichtman AH; Department of Pathology, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.
- Both IL-4 and IL-10 are regulatory cytokines produced by Th2 cells that can down-regulate cell-mediated immune responses. The studies reported here examine the influence of various cytokines in the regulation of T cell IL-10 production. The results indicate that IL-10 gene expression by TCR transgenic Th2 cells is sig
- Differential effects of type I IFNs on the growth of WC1- CD8+ gamma delta T cells and WC1+ CD8- gamma delta T cells in vitro.
- J Immunol. 1999 Jan 1;162(1):245-53. Unique Identifier : AIDSLINE MED/99101483
- Tuo W; Bazer FW; Davis WC; Zhu D; Brown WC; Department of Veterinary Pathology and Microbiology, Washington; State University, Pullman 99164, USA.
- Type I IFNs have a broad array of immunoregulatory functions that include up-regulation of type 1 immune responses through enhancing differentiation and activation of CD8+ T cells and CD4+ Th1 cells. Ovine trophoblast IFN-tau is a recently described type I IFN with the potential for therapeutic use, based on its poten
- A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: induction of lymph node homing and apoptosis upon secondary signaling through homing receptors.
- J Immunol. 1999 Jan 1;162(1):268-76. Unique Identifier : AIDSLINE MED/99101486
- Wang L; Chen JJ; Gelman BB; Konig R; Cloyd MW; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555, USA.
- Recently, we reported that abortive HIV infection of resting human T lymphocytes up-regulated expression of CD62L, the receptor for homing to lymph nodes (LNs), and enhanced homing of these cells from the blood into the LNs (Wang et al., 1997, Virology 228:141). This suggested that HIV-induced homing of resting lympho
- A selective defect of IFN-gamma- but not of IFN-alpha-induced JAK/STAT pathway in a subset of U937 clones prevents the antiretroviral effect of IFN-gamma against HIV-1.
- J Immunol. 1999 Jan 1;162(1):323-30. Unique Identifier : AIDSLINE MED/99101493
- Bovolenta C; Lorini AL; Mantelli B; Camorali L; Novelli F; Biswas P; Poli G; AIDS Immunophatogenesis Unit, San Raffaele Scientific Institute,; Milan, Italy. bovolenta.chiara@hsr.it
- IFN-gamma induces transcription of several IFN-stimulated genes (ISGs). Recently, the IFN-gamma-dependent Janus kinase (JAK)/STAT pathway has been shown to mediate the activation of some ISGs, by the sequential phosphorylation of two JAK kinases (JAK1 and JAK2) and of STAT1. Given that the JAK/STAT is the major, but n
- CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.
- J Immunol. 1999 Jan 1;162(1):366-71. Unique Identifier : AIDSLINE MED/99101499
- Rosat JP; Grant EP; Beckman EM; Dascher CC; Sieling PA; Frederique D; Modlin RL; Porcelli SA; Furlong ST; Brenner MB; Department of Medicine, Brigham & Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.
- It is generally accepted that TCR alphabeta+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infections. Here, we re
- Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.
- J Immunol. 1999 Jan 1;162(1):372-9. Unique Identifier : AIDSLINE MED/99101500
- Canaday DH; Ziebold C; Noss EH; Chervenak KA; Harding CV; Boom WH; Department of Medicine, Case Western Reserve University,; University Hospitals of Cleveland, OH 44106, USA. dxc44@cwru.edu
- Human immune responses to M. tuberculosis are characterized by activation of multiple T cell subsets including CD4+, CD8+, and gammadelta T cells, and the role of CD8+ alphabeta TCR+ T cells in this response is poorly understood. Stimulation of T cells from healthy tuberculin skin test-positive persons with live M. tu
- Activation-induced resistance of human macrophages to HIV-1 infection in vitro.
- J Immunol. 1999 Jan 1;162(1):400-6. Unique Identifier : AIDSLINE MED/99101504
- Zybarth G; Reiling N; Schmidtmayerova H; Sherry B; Bukrinsky M; The Picower Institute for Medical Research, Manhasset, NY 11030,; USA.
- Cells of the monocyte/macrophage lineage are the first targets of HIV-1 in patients and also serve as reservoirs for the virus during the course of infection. We investigated the effects of cell activation on early events of HIV-1 infection of monocyte-derived macrophages. Addition of LPS, a potent stimulator of macro
- Complement-mediated anti-HIV-1 effect induced by human IgM monoclonal antibody against ganglioside GM2.
- J Immunol. 1999 Jan 1;162(1):533-9. Unique Identifier : AIDSLINE MED/99101521
- Wu X; Okada N; Momota H; Irie RF; Okada H; Department of Molecular Biology, Nagoya City University School of; Medicine, Japan.
- HIV-infected cells aberrantly express a high level of antigenic glycosidic structures such as GM2 and Gg4. Some normal sera containing natural IgM Abs to GM2 and/or Gg4 cause C-mediated cytolysis of HIV-infected cells. In the present study we demonstrated that a human IgM anti-GM2 mAb (L55 Ab) can induce cytolysis of
- Selective induction of protective MHC class I-restricted CTL in the intestinal lamina propria of rhesus monkeys by transient SIV infection of the colonic mucosa.
- J Immunol. 1999 Jan 1;162(1):540-9. Unique Identifier : AIDSLINE MED/99101522
- Murphey-Corb M; Wilson LA; Trichel AM; Roberts DE; Xu K; Ohkawa S; Woodson B; Bohm R; Blanchard J; Tulane Regional Primate Research Center, Covington, LA 70433,; USA. mcorb+@pitt.edu
- The identification of mucosal immune responses required for protection against sexual transmission of HIV is essential for the development of an efficacious vaccine. To gain a better understanding of these responses, we have characterized the immune responses in the lamina propria (LP) and epithelium of the jejunum, t
- High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer.
- J Immunol. 1999 Jan 1;162(1):609-17. Unique Identifier : AIDSLINE MED/99101530
- Fernandez NC; Levraud JP; Haddada H; Perricaudet M; Kourilsky P; Laboratoire de Vectorologie et Transfert de Genes, Centre; National de la Recherche Scientifique-Unite Mixte de Recherche; 1582, Institut Gustave Roussy, Villejuif, France.
- Cancer immunotherapy often aims at the reactivation and expansion of tumor-specific CTL. In an attempt to correlate in situ and/or systemic tumor-specific T cell expansion with tumor regression, we investigated the effects of adenovirus-mediated IL-12 or IFN-gamma gene transfer into established P815 murine tumors. Whi
- Low rate of Clostridium difficile colonization in ambulatory and hospitalized HIV-infected patients in a hospital unit: a prospective survey.
- J Infect. 1998 Sep;37(2):108-11. Unique Identifier : AIDSLINE MED/99038523
- Mainardi JL; Lacassin F; Guilloy Y; Goldstein FW; Leport C; Acar JF; Vilde JL; Laboratoire de Microbiologie Clinique, Fondation Hopital; Saint-Joseph, Paris, France.
- OBJECTIVE: To determine the frequency of Clostridium difficile carriage in HIV-infected in- and out-patients, and to assess the role of this carriage in nosocomial transmission of C. difficile. PATIENTS AND METHODS: Prospective study in a university hospital. Forty-five consecutive HIV-infected out-patients and 120 ho
- Changing role of invasive aspergillosis in AIDS--a case control study.
- J Infect. 1998 Sep;37(2):116-22. Unique Identifier : AIDSLINE MED/99038525
- Woitas RP; Rockstroh JK; Theisen A; Leutner C; Sauerbruch T; Spengler U; Department of General Internal Medicine, University of Bonn,; Germany.
- OBJECTIVE: From December 1993 until January 1996 we observed 10 cases of invasive aspergillosis in a cohort of 140 patients with AIDS (7%). By contrast, no invasive aspergillosis was diagnosed in a cohort of 278 patients with AIDS between 1986 until 1993. METHODS: Case controls were assigned randomly to each patient w
- Pilot study to estimate survivors to 1995 of 1983-1984 prevalent hepatitis C infections in Lothian patients who tested positive or negative for hepatitis B surface antigen in 1983-1984.
- J Infect. 1998 Sep;37(2):159-65. Unique Identifier : AIDSLINE MED/99038532
- Gore SM; Brettle RP; Burns SM; Lewis SC; MRC Biostatistics Unit, Cambridge, U.K.
- OBJECTIVE: To estimate Hepatitis C prevalence in 1983-1984, and survivorship to 1 January 1995, of patients who tested were for Hepatitis B surface antigen in 1983-1984; and to do so according to risk of blood-borne virus transmission, including injector status. SETTING: Regional Virus Laboratory in Edinburgh. SAMPLES
- Early mortality of undiagnosed but prevalent (in 1983-1984) HIV infection in Lothian injectors who tested hepatitis B surface antigen positive (group A) or negative but were high risk for blood-borne virus transmission (group B) in 1983-1984.
- J Infect. 1998 Sep;37(2):166-72. Unique Identifier : AIDSLINE MED/99038533
- Gore SM; Brettle RP; Burns SM; Lewis SC; MRC Biostatistics Unit, Cambridge, U.K.
- OBJECTIVE: To estimate the early death-rate in HIV infected injectors whose HIV infection was during the injection-related HIV outbreak in Lothian region in Scotland in 1983-1984, which was coincident with Hepatitis B transmissions. SETTING: Regional Virus Laboratory in Edinburgh. SAMPLES: Sera from 1983-1984, origina
- Cytomegalovirus retinitis, human immunodeficiency virus antibody positivity and normal T helper cell numbers.
- J Infect. 1998 Sep;37(2):186-8. Unique Identifier : AIDSLINE MED/99038537
- Thomson RM; Conrad D; Antoszewska H; Croxson MC; McCormack JG; University Department of Medicine and Infectious Diseases, Mater; Hospital, South Brisbane, Australia.
- We describe a 46-year-old man in whom retinitis was diagnosed as his initial HIV and AIDS defining illness. A diagnosis of CMV infection was made based on the clinical appearance of the fundus and confirmed by DNA polymerase chain reaction (PCR) on his vitreous
- Muscular bacillary angiomatosis in AIDS.
- J Infect. 1998 Sep;37(2):193. Unique Identifier : AIDSLINE MED/99038540
- Blanche P; Bachmeyer C; Salmon-Ceron D; Sicard D; Service of Internal Medicine, Hopital Cochin, Universite Rene; Descartes, Paris, France.
- We describe an unusual case of bacillary angiomatosis first misdiagnosed as Kaposi s sarcoma in muscle in a patient with HIV infection.
- Role of CD8+ and WC-1+ gamma/delta T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse.
- J Leukoc Biol. 1999 Jan;65(1):28-34. Unique Identifier : AIDSLINE MED/99101334
- Smith RA; Kreeger JM; Alvarez AJ; Goin JC; Davis WC; Whipple DL; Estes DM; Department of Veterinary Pathobiology, University of; Missouri-Columbia, 65211, USA.
- The role of various effector T cell populations in the bovine immune response to Mycobacterium bovis infection is poorly understood. This is largely due to the difficulties associated with performing in vivo challenge studies in the natural host species. In this report, we utilized a fetal bovine-severe combined immun
- B cells directly tolerize CD8(+) T cells.
- J Exp Med. 1998 Dec 7;188(11):1977-83. Unique Identifier : AIDSLINE MED/99059822
- Bennett SR; Carbone FR; Toy T; Miller JF; Heath WR; Immunology Division, The Walter and Eliza Hall Institute of; Medical Research, The Royal Melbourne Hospital, Melbourne,; Victoria 3050, Australia.
- This report investigates the response of CD8(+) T cells to antigens presented by B cells. When C57BL/6 mice were injected with syngeneic B cells coated with the Kb-restricted ovalbumin (OVA) determinant OVA257-264, OVA-specific cytotoxic T lymphocyte (CTL) tolerance was observed. To investigate the mechanism of tolera
- Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice.
- J Exp Med. 1998 Dec 7;188(11):1993-2005. Unique Identifier : AIDSLINE MED/99059824
- Lin MY; Welsh RM; Department of Pathology and Program in Immunology and Virology,; University of Massachusetts Medical School, Worcester,; Massachusetts 01655, USA.
- Numerous studies have examined T cell receptor (TCR) usage of selected virus-specific T cell clones, yet little information is available regarding the stability and diversity of TCR repertoire usage during viral infections. Here, we analyzed the Vbeta8.1 TCR repertoire directly ex vivo by complementarity-determining r
- Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity.
- J Exp Med. 1998 Dec 7;188(11):2019-31. Unique Identifier : AIDSLINE MED/99059826
- Stumbles PA; Thomas JA; Pimm CL; Lee PT; Venaille TJ; Proksch S; Holt PG; TVW Telethon Institute for Child Health Research (affiliated with; the University of Western Australia), West Perth, Western; Australia 6872, Australia.
- Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity. However, the default T helper response at mucosal surfaces demonstrates Th2 polarity, which is reflected in the cytokine profiles of activated
- Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.
- J Exp Med. 1998 Dec 7;188(11):2057-65. Unique Identifier : AIDSLINE MED/99059829
- Chen Z; Kwon D; Jin Z; Monard S; Telfer P; Jones MS; Lu CY; Aguilar RF; Ho DD; Marx PA; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York 10016, USA.
- A homozygous 24-bp deletion (Delta24) was found in the CC chemokine receptor 5 (CCR5) of 11 out of 15 red-capped mangabeys (RCMs), Cercocebus torquatus torquatus, both in Africa and in an American zoo. The CCR5 Delta24 defect encompassed eight amino acids in frame in the fourth transmembrane region. Unexpectedly, RCM-
- Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.
- J Exp Med. 1998 Dec 7;188(11):2113-25. Unique Identifier : AIDSLINE MED/99059835
- Bukrinskaya A; Brichacek B; Mann A; Stevenson M; Program in Molecular Medicine, University of Massachusetts; Medical Center, Worcester, Massachusetts 01605, USA.
- After interaction of human immunodeficiency virus type 1 (HIV-1) virions with cell surface receptors, a series of poorly characterized events results in establishment of a viral reverse transcription complex in the host cell cytoplasm. This process is coordinated in such a way that reverse transcription is initiated s
- Current issues in the midwifery management of women living with HIV/AIDS.
- J Nurse Midwifery. 1998 Nov-Dec;43(6):502-25. Unique Identifier : AIDSLINE MED/99088549
- MacLaren A; Imberg W; Department of Family and Child Nursing, School of Nursing,; University of Washington, Seattle 98195-7262, USA.
- Changes in the clinical management of women living with human immunodeficiency virus (HIV) have occurred as a result of significant gains in the scientific knowledge of this retrovirus. As the incidence of HIV/AIDS continues to escalate among female adults and adolescents in the United Sta
- Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in healthy non-HIV-infected people.
- J Oral Pathol Med. 1998 Nov;27(10):480-2. Unique Identifier : AIDSLINE MED/99048800
- Scully C; Porter SR; Di Alberti L; Jalal M; Maitland N; Eastman Dental Institute for Oral Health Care Sciences,; University of London, UK.
- Epstein Barr virus (EBV) has been implicated in the pathogenesis of oral hairy leukoplakia (OHL). EBV is normally detected by lesional biopsy. The objectives of this study were to examine oral scrapes containing squamous epithelial cells (squames) from HIV-infected people with and without clinical lesions of OHL, and
- (R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.
- J Med Chem. 1998 Dec 17;41(26):5257-64. Unique Identifier : AIDSLINE MED/99075953
- Qiu YL; Hempel A; Camerman N; Camerman A; Geiser F; Ptak RG; Breitenbach JM; Kira T; Li L; Gullen E; Cheng YC; Drach JC; Zemlicka J; Department of Chemistry, Experimental and Clinical Chemotherapy; Program, Barbara Ann Karmanos Cancer Institute, Wayne State; University School of Medicine, Detroit, Michigan 48201-1379, USA.
- Synthesis of (R)-(-)- and (S)-(+)-synadenol (1a and 2a, 95-96% ee) is described. Racemic synadenol (1a + 2a) was deaminated with adenosine deaminase to give (R)-(-)-synadenol (1a) and (S)-(+)-hypoxanthine derivative 5. Acetylation of the latter compound gave acetate 6. Reaction with N, N-dimethylchloromethyleneammoniu
- Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.
- J Med Chem. 1998 Dec 17;41(26):5272-86. Unique Identifier : AIDSLINE MED/99075955
- Smith RH Jr; Jorgensen WL; Tirado-Rives J; Lamb ML; Janssen PA; Michejda CJ; Kroeger Smith MB; Department of Chemistry, Western Maryland College, Westminster,; Maryland 21157, USA.
- Monte Carlo (MC) simulations in combination with a linear response approach were used to estimate the free energies of binding for a series of 12 TIBO nonnucleoside inhibitors of HIV-1 reverse transcriptase. Separate correlations were made for the R6 and S6 absolute conformations of the inhibitors, as well as for the
- Characterization of lectin-mediated brain uptake of HIV-1 GP120.
- J Neurosci Res. 1998 Nov 15;54(4):522-9. Unique Identifier : AIDSLINE MED/99037956
- Banks WA; Kastin AJ; GRECC, Veterans Affairs Medical Center-St. Louis, Department of; Internal Medicine, Saint Louis University School of Medicine,; Missouri, USA.
- The viral coat of the HIV-1 virus, gp120, has been shown to cross the blood-brain barrier (BBB) in lectin-like fashion by inducing adsorptive endocytosis (AE), a vesicular mechanism that could provide pathways into and across brain endothelial cells for virus and infected immune cells. Here, we extended those findings
- Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor.
- J Neurosci Res. 1998 Nov 15;54(4):530-8. Unique Identifier : AIDSLINE MED/99037957
- Pulliam L; Zhou M; Stubblebine M; Bitler CM; Department of Laboratory Medicine, University of California, San; Francisco, Veterans Affairs Medical Center, USA.
- Programmed cell death contributes to the morbidity and mortality of several neurological disorders including stroke, Alzheimer s disease and human immunodeficiency virus (HIV)-associated dementia . Patients with HIV dementia show evidence of programmed cell death in brain. In vitro
- Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies.
- Lab Invest. 1998 Dec;78(12):1523-33. Unique Identifier : AIDSLINE MED/99096279
- Iizuka J; Katagiri Y; Tada N; Murakami M; Ikeda T; Sato M; Hirokawa K; Okada S; Hatano M; Tokuhisa T; Uede T; Institute of Immunological Science, Hokkaido University, Sapporo,; Japan.
- Osteopontin (OPN) is an Arg-Gly-Asp-containing phosphoprotein that is secreted by activated T cells. The concentration of serum OPN protein is elevated in autoimmune-prone MRL-lpr mice as well as in patients with systemic lupus erythematosus. Previously, it was shown that OPN induces the polyclonal activation of B cel
- Expression of human herpesvirus-8 oncogene and cytokine homologues in an HIV-seronegative patient with multicentric Castleman's disease and primary effusion lymphoma.
- Lab Invest. 1998 Dec;78(12):1637-42. Unique Identifier : AIDSLINE MED/99096291
- Teruya-Feldstein J; Zauber P; Setsuda JE; Berman EL; Sorbara L; Raffeld M; Tosato G; Jaffe ES; Laboratory of Pathology, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-1500, USA.
- Human herpesvirus-8 (HHV-8) has been described in association with two lymphoproliferative disorders: one benign, multicentric Castleman s disease (MCD), and one malignant, primary effusion lymphoma (PEL). The factors that lead to malignant transformation of lymphoid cells are unknown, although most cases of PEL also
- Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70.
- Mech Ageing Dev. 1998 Aug 1;104(1):41-58. Unique Identifier : AIDSLINE MED/98422051
- Chakravarti B; Chakravarti DN; Devecis J; Seshi B; Abraham GN; Department of Medicine and Center on Aging, University of; Rochester Medical Center, NY 14642, USA.
- Several events of T cell activation have been reported to decline in humans with age. Since protein tyrosine phosphorylation is an early critical event of T cell activation, we performed a systematic analysis of the age-associated changes in the mitogen induced protein tyrosine phosphorylation of human T lymphocytes u
- Jonathan Mann's mantle [letter]
- Lancet. 1998 Dec 19-26;352(9145):2025. Unique Identifier : AIDSLINE MED/99087289
- Schusky RW
- Determination of Epstein-Barr virus (EBV) load by RT-PCR and cellular dilution.
- Mol Cell Probes. 1998 Dec;12(6):427-30. Unique Identifier : AIDSLINE MED/99061906
- Orentas RJ; Section of Hematology-Oncology, The Medical College of Wisconsin,; 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
- Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus which establishes life-long latency in the B-lymphocytes of infected individuals. Epstein-Barr virus is associated with Hodgkin s disease, AIDS-associated lymphoma and post-transplant lymphoproliferative disease (PTLD). In PTLD, the onset of malignancy correla
- A randomized, controlled trial of a behavioral intervention to prevent sexually transmitted disease among minority women.
- N Engl J Med. 1999 Jan 14;340(2):93-100. Unique Identifier : AIDSLINE MED/99091093
- Shain RN; Piper JM; Newton ER; Perdue ST; Ramos R; Champion JD; Guerra FA; Department of Obstetrics and Gynecology, University of Texas; Health Science Center at San Antonio, 78284-7836, USA.
- BACKGROUND: African-American and Hispanic women are disproportionately affected by sexually transmitted diseases, including the acquired immunodeficiency syndrome (AIDS). In the effort to reduce infection rates, it is important to create and evaluate behavioral interventions that are specific to the target populations
- Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1 [letter]
- N Engl J Med. 1999 Jan 21;340(3):236-7. Unique Identifier : AIDSLINE MED/99101878
- Greenough TC; Sullivan JL; Desrosiers RC
- Setting a bad example on AIDS [editorial]
- Nature. 1998 Dec 17;396(6712):603. Unique Identifier : AIDSLINE MED/99087297
- Changes in thymic function with age and during the treatment of HIV infection [see comments]
- Nature. 1998 Dec 17;396(6712):690-5. Unique Identifier : AIDSLINE MED/99087324
- Douek DC; McFarland RD; Keiser PH; Gage EA; Massey JM; Haynes BF; Polis MA; Haase AT; Feinberg MB; Sullivan JL; Jamieson BD; Zack JA; Picker LJ; Koup RA; Department of Medicine, The University of Texas Southwestern; Medical Center, Dallas 75235, USA.
- The thymus represents the major site of the production and generation of T cells expressing alphabeta-type T-cell antigen receptors. Age-related involution may affect the ability of the thymus to reconstitute T cells expressing CD4 cell-surface antigens that are lost during HIV infection; this effect has been seen aft
- DNA breaks detected by in situ end-labelling in dorsal root ganglia of patients with AIDS.
- Neuropathol Appl Neurobiol. 1998 Oct;24(5):373-80. Unique Identifier : AIDSLINE MED/99038609
- Adle-Biassette H; Bell JE; Creange A; Sazdovitch V; Authier FJ; Gray F; Hauw JJ; Gherardi R; Departement de Pathologie (Neuropathologie), CHU Henri Mondor,; Creteil, France.
- Distal sensory axonal polyneuropathy (DSP) is the most frequent HIV-associated peripheral neuropathy . DSPs tend to occur in full-blown AIDS and worsen as CD4 cell counts decrease in blood. To assess a possible role for apoptosis in the pathogenesis of the neuropathy,
- Mycobacterial infections in patients with HIV: a review of disease and care [news]
- Unique Identifier : AIDSLINE MED/99022149
- Hendell M
- HIV drug now approved for use with protease inhibitors.
- Nurse Pract. 1998 Oct;23(10):89. Unique Identifier : AIDSLINE MED/99022151
- [Position of the Scientific Medical Council on the antitumor studies conducted in Hungary on the Newcastle disease virus]
- Orv Hetil. 1998 Nov 29;139(48):2903-5. Unique Identifier : AIDSLINE MED/99112279
- New epidemiological problem in Poland: vertical transmission of human immunodeficiency virus.
- Paediatr Perinat Epidemiol. 1998 Oct;12(4):459-62. Unique Identifier : AIDSLINE MED/99022560
- Lech MM; Szczepanska-Putz M; Department of Epidemiology, State Research Mother and Child; Institute, Warszawa, Poland.
- New diagnostic, prophylactic and treatment perspectives in HIV infection of the fetus and newborn is a challenge for health services in Poland . In view of these advances, the ascertainment of HIV status of all pregnant women is impo
- [Myocardial infarct induced by antiproteases. Report of a case (letter)]
- Presse Med. 1998 Dec 5;27(38):1955-6. Unique Identifier : AIDSLINE MED/99095392
- Khellaf M; Thiebaut MM; Caumes E; Bricaire F
- [Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using T-activin]
- Probl Tuberk. 1998;(5):46-8. Unique Identifier : AIDSLINE MED/99083632
- Adambekov DA; Litvinov VI; Mambetov KB; Koshmuratov AG; Sabyrbekova TS
- Fifty six patients with pulmonary tuberculosis were examined. Of them 30 had T-activin in multimodality treatment. To supplement the agent in elderly and old patients was found to elevate the counts of T lymphocytes and T helper cells, to normalize Tx/Tc ratios, to enhance T lymphocytic activity and
- Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension.
- Proteins. 1998 Oct 1;33(1):135-43. Unique Identifier : AIDSLINE MED/98412882
- Goedken ER; Marqusee S; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA.
- Reverse transcriptase (RT) is a modular enzyme carrying polymerase and ribonuclease H (RNase H) activities in separable domains. Retroviral replication requires both of these activities. The RNase H domain is responsible for hydrolysis of the RNA portion of RNA x DNA hybrids, and this activity requires the presence of
- HIV envelope protein gp120 induces neuropeptide Y receptor-mediated proliferation of vascular smooth muscle cells: relevance to AIDS cardiovascular pathogenesis.
- Regul Pept. 1998 Sep 25;75-76:201-5. Unique Identifier : AIDSLINE MED/99017396
- Kim J; Ruff M; Karwatowska-Prokopczuk E; Hunt L; Ji H; Pert CB; Zukowska-Grojec Z; Department of Physiology and Biophysics, Georgetown University; Medical Center, Washington, DC, USA.
- Hyperplasia of vascular smooth muscle cells (VSMCs) occurs during HIV infection, part of a spectrum of HIV-mediated cardiovascular and microvascular pathologies. These changes are not due to direct viral infection but may involve the receptor-mediated action of viral proteins, such as the envelope protein gp120. We so
- [Histopathological and immunohistochemical characteristics of cutaneous and oral mucosa lesions in disseminated histoplasmosis associated with acquired immunodeficiency syndrome (AIDS)]
- Rev Soc Bras Med Trop. 1998 Nov-Dec;31(6):539-47. Unique Identifier : AIDSLINE MED/99076795
- D'Avila SC; Chapadeiro E; Faculdade de Medicina do Triangulo Mineiro, Uberaba.
- Biopsy specimens of the skin and oral mucosa from twenty-five patients bearing the disseminated form of histoplasmosis (H. capsulatum) associated with AIDS (acquired immunodeficiency syndrome) were studied by histologic and immunohistochemistry techniques. Histologically, the skin lesions showed four different pattern
- [Progressive multifocal leukoencephalopathy as initial manifestation of acquired immunodeficiency]
- Rev Soc Bras Med Trop. 1998 Nov-Dec;31(6):569-74. Unique Identifier : AIDSLINE MED/99076800
- de Lima MA; de Andrade FV; Etchebehere RM; Silva-Vergara ML; Trabalho realizado na Faculdade de Medicina do Triangulo Mineiro; (FMTM), Uberaba, MG. lima@mednet.com.br
- This is a report of a man with acquired immunodeficiency syndrome (AIDS) who presented acutely ill with severe progressive multifocal leukoencephalopathy (PML) as the first manifestation of AIDS. PML was diagnosed in the brain after gross and microscopical examination as well as by immunohistochemistry with an antibod
- [Cost effectiveness of the treatment of HIV infection (letter)]
- Rev Soc Bras Med Trop. 1998 Nov-Dec;31(6):581-2. Unique Identifier : AIDSLINE MED/99076803
- Amato Neto V; Pasternak J
- [Vertical transmission rate of the immunodeficiency virus: determinant factors and comparison of results]
- Rev Clin Esp. 1998 Sep;198(9):571-9. Unique Identifier : AIDSLINE MED/99020617
- Sanz Aliaga SA; Sabater Pons A; Asensi Botet F; Perez-Tamarit MD; Servicio de Farmacia, Hospital Universitario La Fe, Valencia.
- Although all newborns to HIV-seropositive mothers have IgG anti-HIV antibodies, since these antibodies cross the placental barrier, only a small proportion of these children are actually infected with the virus. The main objective of this study consisted in estimating the vertical transmission rate of HIV in our envir
- [Bronchial malacoplakia associated with Rhodococcus equi pneumonia in a patient with acquired immunodeficiency syndrome (letter)]
- Rev Clin Esp. 1998 Sep;198(9):630-1. Unique Identifier : AIDSLINE MED/99020631
- Alcalde Encinas MM; Garcia Garcia J; Martinez Madrid OJ; Garcia Henarejos JA
- [Nocardiosis in patients with the human immunodeficiency virus in Spain. Two years later]
- Rev Clin Esp. 1998 Sep;198(9):632-3. Unique Identifier : AIDSLINE MED/99020633
- Yniguez R; Garcia-Onieva E; Sanchez JF; Pascua FJ; Martin C
- [Efficacy and tolerance of a combination of AZT, DDC, and saquinavir in patients infected with the human immunodeficiency virus (letter)]
- Rev Clin Esp. 1998 Sep;198(9):634-5. Unique Identifier : AIDSLINE MED/99020635
- Soriano Vazquez V; Rodriguez-Rosado Martinez-Echevarria R; Jimenez-Nacher I; Valencia Ortega E; Moreno Celda V; Gonzalez-Lahoz J
- Should condom use be promoted for contraception to prevent transmission of sexual transmitted diseases and AIDS? ACSF Group. French National Survey of Sexual behavior.
- Rev Epidemiol Sante Publique. 1998 Nov;46(5):391-7. Unique Identifier : AIDSLINE MED/99082287
- Bajos N; Warszawski J; Ducot B; Spira A; INSERM U 292, Hopital de Bicetre, Le Kremlin Bicetre France.
- BACKGROUND: This study is an exploration of the relationship between the use of oral contraceptive or intrauterine device and condom use. The results should help us better understand how promoting condoms for contraception as compared to sexually transmitted disease prophylaxis might be an effective way of increasing
- [AIDS. Account of the 12th world conference on AIDS Geneva, 28 June-3 July 1998]
- Rev Med Interne. 1998 Nov;19(11):773-6. Unique Identifier : AIDSLINE MED/99082292
- Mercie P; Clinique de medecine interne et maladies infectieuses, hopital; Haut-Leveque, Pessac.
- [Comparison of cases of isolated pulmonary tuberculosis with cases of other localizations of tuberculosis in the course of an active surveillance (Gironde, 1995-1996)]
- Rev Med Interne. 1998 Nov;19(11):792-8. Unique Identifier : AIDSLINE MED/99082296
- Daucourt V; Petit S; Pasquet S; Portel L; Courty G; Dupon M; Texier-Maugein J; Meynard J; Salamon M; Dabis F; Tessier JF; Reseau tuberculose Gironde, Inserm U330, universite; Victor-Segalen Bordeaux, France.
- PURPOSE: Data collected during the years 1995 and 1996 in the course of an epidemiological survey of tuberculosis in Gironde allowed comparison of pulmonary tuberculosis with extrapulmonary localizations, evaluation of the importance of each localization and highlighting of potential risk factors. METHODS: Patients li
- Incorporating correlations between measurements into the estimation of age-related reference ranges.
- Stat Med. 1998 Sep 15;17(17):1989-2002. Unique Identifier : AIDSLINE MED/98450866
- Wade AM; Ades AE; Institute of Child Health, London, U.K. A.Wade@ich.ucl.ac.uk
- An LMS-based maximum likelihood method of fitting age-related reference ranges is extended to incorporate non-independent measurements by including the matrix of the correlations between standard normalized repeat measurements into the likelihood. The likelihood is maximized via iterative re-estimation of the correlat
- A Markov mixed effect regression model for drug compliance.
- Stat Med. 1998 Oct 30;17(20):2313-33. Unique Identifier : AIDSLINE MED/99037265
- Girard P; Blaschke TF; Kastrissios H; Sheiner LB; Department of Biopharmaceutical Sciences, School of Pharmacy,; University of California San Francisco 94143-0626, USA.
- Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects and a set of indiv
- Semi-parametric models for mismeasured exposure information in vaccine trials.
- Stat Med. 1998 Oct 30;17(20):2335-52. Unique Identifier : AIDSLINE MED/99037266
- Golm GT; Halloran ME; Longini IM Jr; Department of Biostatistics, Rollins School of Public Health,; Emory University, Atlanta, GA 30322, USA.
- Exposure to infection information is important for estimating vaccine efficacy, but it is difficult to collect and inherently prone to missingness and mismeasurement. It is, therefore, generally not feasible to collect good exposure information on all participants in a large vaccine trial. We discuss study designs tha
- Does the covariance structure matter in longitudinal modelling for the prediction of future CD4 counts?
- Stat Med. 1998 Oct 30;17(20):2381-94. Unique Identifier : AIDSLINE MED/99037269
- Taylor JM; Law N; Department of Biostatistics, University of California, Los; Angeles 90095-1772, USA.
- We investigate the importance of the assumed covariance structure for longitudinal modelling of CD4 counts. We examine how individual predictions of future CD4 counts are affected by the covariance structure. We consider four covariance structures: one based on an integrated Ornstein-Uhlenbeck stochastic process; one
- Design of HIV viral dynamics studies.
- Stat Med. 1998 Nov 15;17(21):2421-34. Unique Identifier : AIDSLINE MED/99037272
- Marschner IC; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115, USA. marsch@sdac.harvard.edu
- HIV viral dynamics studies involve repeated measurement of viral load in HIV-infected individuals, to assess short-term rates of viral load change in response to interventions such as initiation or withdrawal of antiviral therapy. Such studies are an important source of information on HIV pathogenesis. This paper conc
- Statistical issues for HIV surrogate endpoints: point/counterpoint. An NIAID workshop.
- Stat Med. 1998 Nov 15;17(21):2435-62. Unique Identifier : AIDSLINE MED/99037273
- Albert JM; Ioannidis JP; Reichelderfer P; Conway B; Coombs RW; Crane L; Demasi R; Dixon DO; Flandre P; Hughes MD; Kalish LA; Larntz K; Lin D; Marschner IC; Munoz A; Murray J; Neaton J; Pettinelli C; Rida W; Taylor JM; Welles SL; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892-7620,; USA. ja24o@nih.gov
- This paper summarizes the proceedings of an NIAID-sponsored workshop on statistical issues for HIV surrogate endpoints. The workshop brought together statisticians and clinicians in an attempt to shed light on some unresolved issues in the use of HIV laboratory markers (such as HIV RNA and CD4+ cell counts) in the des
- Estimation of HIV dynamic parameters.
- Stat Med. 1998 Nov 15;17(21):2463-85. Unique Identifier : AIDSLINE MED/99037274
- Wu H; Ding AA; De Gruttola V; Frontier Science & Technology Research Foundation, Chestnut Hill,; MA 02167-2104, USA. wu@sdac.harvard.edu
- Investigation of HIV viral dynamics is important for understanding the HIV pathogenesis and for development of treatment strategies. Perelson et al. demonstrated that simple viral dynamic models fit to data on viral load as measured by plasma HIV-RNA could produce estimates of rates of clearance of virus and of infect
- [Diagnosis and treatment of ocular viral infections in AIDS patients]
- Rev Med Suisse Romande. 1998 Nov;118(11):941-7. Unique Identifier : AIDSLINE MED/99082642
- Guex-Crosier Y; Hopital ophtalmique Jules Gonin, Lausanne.
- Ocular complication of AIDS are seen in about 75% of patients. Viral infections are predominant and can involve either external segment in the eye (Herpes type 8 in Kaposi sarcoma, molluscum contagiosum, Herpes simplex and zoster), or the posterior segment of the eye (
- A case of Crohn's disease with increased CD8 T-cell activation and remission during therapy with intravenous immunoglobulins.
- Scand J Gastroenterol. 1998 Oct;33(10):1113-7. Unique Identifier : AIDSLINE MED/99044834
- Korber J; Kottgen E; Renz H; Medical Clinic and Policlinic, and Institute of Laboratory; Medicine and Pathobiochemistry, Charite Campus Virchow-Klinikum,; Humboldt University of Berlin, Germany.
- BACKGROUND: Crohn s disease (CD) represents a chronic inflammatory bowel disease with abnormal CD8 T-cell function in a subgroup of patients. METHODS: A 55-year-old woman presented with CD on the basis of clinical, endoscopic, radiologic, histologic, and sonographic examination. Since the disease could not be controll
- Clinical features, immunological changes and mortality in a cohort of HIV-2-infected individuals in Bissau, Guinea-Bissau.
- Scand J Infect Dis. 1998;30(4):323-9. Unique Identifier : AIDSLINE MED/99032447
- Norrgren H; Da Silva ZJ; Andersson S; Biague AJ; Dias F; Biberfeld G; Naucler A; National Public Health Laboratory, Bissau, Guinea-Bissau,; Guinea-Bissau.
- Clinical symptoms and immunological changes associated with HIV-2 infection were studied in a cohort of police officers in Guinea-Bissau . HIV-related symptoms were classified according to the WHO clinical staging system. The inclusion period was from January 1990 to January 1997,
- Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature.
- Scand J Infect Dis. 1998;30(4):331-8. Unique Identifier : AIDSLINE MED/99032448
- Leder K; Ryan N; Spelman D; Crowe SM; Monash Medical Centre, Clayton, Victoria, Australia.
- Microsporidiosis is recognized as an increasingly important infection, particularly in patients with human immunodeficiency virus (HIV) infection. In this retrospective study we have reviewed the clinical features, laboratory findings and management of 42 HIV positive patients co-infected with microsporidia. All patie
- Lack of T-lymphocytosis and poor interferon gamma production in BAL fluid from HIV-negative immunocompetent patients with pulmonary non-tuberculous mycobacteriosis.
- Scand J Infect Dis. 1998;30(4):339-43. Unique Identifier : AIDSLINE MED/99032449
- Heurlin N; Bergstrom SE; Andersson J; Christensson M; Christensson B; Department of Medicine, Karolinska Institute, Huddinge University; Hospital, Sweden.
- Very little is known about the pathogenesis of pulmonary non-tuberculous mycobacteriosis in immunocompetent individuals. Local inflammatory response was assessed by examining bronchoalveolar lavage fluid from 13 HIV-negative patients (12 F) without known cell-mediated immunosuppression, aged 48-72 y (median age 60 y),
- Candidal meningitis in HIV-infected patients: treatment with fluconazole.
- Scand J Infect Dis. 1998;30(4):417-8. Unique Identifier : AIDSLINE MED/99032463
- Rodriguez-Arrondo F; Aguirrebengoa K; De Arce A; Arrizabalaga J; Iribarren JA; Von Wichmann MA; Goenaga MA; Infectious Disease Unit of Hospital Aranzazu, San Sebastian,; Spain.
- Although mucocutaneous candidiasis is a common occurrence in HIV-infected patients, candidal meningitis is uncommon. We report 3 cases of candidal meningitis in HIV-positive patients, all intravenous drug abusers, and we discuss the clinical course and outcome, the treatment with fluconazole and possible prophylaxis.
- A trial comparing nucleoside monotherapy with sequential therapy with 3 drugs in HIV-infected patients.
- Unique Identifier : AIDSLINE MED/99032468
- Roca B; Olmos P
- Requirement for diverse, low-abundance peptides in positive selection of T cells.
- Science. 1999 Jan 1;283(5398):67-70. Unique Identifier : AIDSLINE MED/99102692
- Barton GM; Rudensky AY; Molecular and Cellular Biology Program of the University of; Washington and Fred Hutchinson Cancer Research Center, Seattle,; WA 98195, USA.
- Whether a single major histocompatibility complex (MHC)-bound peptide can drive the positive selection of large numbers of T cells has been a controversial issue. A diverse population of self peptides was shown to be essential for the in vivo development of CD4 T cells. Mice in which all but 5 percent of MHC class II
- Assembly and analysis of conical models for the HIV-1 core.
- Science. 1999 Jan 1;283(5398):80-3. Unique Identifier : AIDSLINE MED/99102696
- Ganser BK; Li S; Klishko VY; Finch JT; Sundquist WI; Department of Biochemistry, University of Utah, Salt Lake City,; UT 84132, USA.
- The genome of the human immunodeficiency virus (HIV) is packaged within an unusual conical core particle located at the center of the infectious virion. The core is composed of a complex of the NC (nucleocapsid) protein and genomic RNA, surrounded by a shell of the CA (capsid) protein. A method was developed for assem
- Sexual behaviour and risk assessment of HIV seroconvertors among urban male factory workers in Zimbabwe.
- Soc Sci Med. 1998 Nov;47(10):1431-43. Unique Identifier : AIDSLINE MED/99040373
- Ray S; Latif A; Machekano R; Katzenstein D; Zimbabwe AIDS Prevention Project (ZAPP-UZ), Department of; Community Medicine, University of Zimbabwe Medical School,; Harare, Zimbabwe.
- Despite extensive HIV prevention programmes and knowledge of people dying of AIDS, people in Zimbabwe continue to be infected with HIV and other sexually transmitted infections (STIs). This paper presents selected case histories from interviews with 57 men who became HIV positive
- Injections and self-help: risk and trust in Ugandan health care.
- Soc Sci Med. 1998 Nov;47(10):1455-62. Unique Identifier : AIDSLINE MED/99040375
- Birungi H; Makerere Institute of Social Research, Makerere University,; Wandegeya, Kampala, Uganda.
- The paper draws upon research material collected during a one year long ethnographic study on injection use and a WHO funded Injection Practices Research Project, which were both carried out during 1992/1993. The paper examines the changing trends in injection use and practices in the context of the Ugandan health sys
- Family responses to HIV/AIDS in Mexico.
- Unique Identifier : AIDSLINE MED/99040377
- Castro R; Orozco E; Aggleton P; Eroza E; Hernandez JJ; Centro Regional de Investigaciones Multidisciplinarias,; Cuernavaca, Mor., Mexico.
- This paper presents findings from a qualitative study of household and community responses to HIV/AIDS in Mexico. Fieldwork took place in two contrasting settings: (a) Ciudad Netzahualcoyotl, a socially marginalized urban community and (b) the homosexual community of Mexico City, a sexually marginalized social network
- Human immunodeficiency virus seroprevalence and condom use among female sex workers in Italy [see comments]
- Sex Transm Dis. 1998 Oct;25(9):451-4. Unique Identifier : AIDSLINE MED/99016636
- Spina M; Mancuso S; Sinicco A; Vaccher E; Traina C; Di Fabrizio N; De Lalla F; Tirelli U; Division of Medical Oncology and AIDS, C.R.O. Aviano, Italy.
- BACKGROUND AND OBJECTIVES: In two different studies, we evaluated the human immunodeficiency virus (HIV) seroprevalence rate and the condom use in a group of female sex workers working in Italy . STUDY DESIGN: In the first study we collected data on HIV serologic testing of female se
- Incidence and sexual risk factors of cytomegalovirus seroconversion in HIV-infected subjects. The SEROCO Study Group.
- Sex Transm Dis. 1998 Oct;25(9):476-80. Unique Identifier : AIDSLINE MED/99016641
- Robain M; Carre N; Dussaix E; Salmon-Ceron D; Meyer L; Department of Public Health/Epidemiology/Human Reproduction,; INSERM 292, Institut National de la Sante et de la Recherche; Medicale, Hopitaldu Kremlin-Bicetre, France.
- BACKGROUND: Data on incidence of cytomegalovirus ( CMV ) seroconversion in HIV-infected (HIV(+)) subjects was sparse. GOAL: To determine the incidence of CMV seroconversion in sexually active HIV(+) subjects and sexual factors
- Gender differences in risk behaviors among HIV+ persons with an IDU history. The link between partner characteristics and women's higher drug-sex risks. The Manif 2000 Study Group.
- Sex Transm Dis. 1998 Oct;25(9):483-8. Unique Identifier : AIDSLINE MED/99016643
- Gollub EL; Rey D; Obadia Y; Moatti JP; Philadelphia Department of Public Health, Pennsylvania, USA.
- BACKGROUND AND OBJECTIVES: Risk-taking behaviors differ among women and men injection drug users (IDU). GOAL: To specify the nature of sexual and drug risk-taking among women IDU and ex-IDU and how it relates to partner characteristics. DESIGN: A cross-sectional analysis of 324 HIV+ subjects enrolled into a prospectiv
- Health improvements.
- Tex Nurs. 1998 Jan;72(1):11. Unique Identifier : AIDSLINE MED/98235181
- Association of cytomegalovirus genotype with graft rejection after liver transplantation.
- Transplantation. 1998 Dec 27;66(12):1627-31. Unique Identifier : AIDSLINE MED/99098719
- Rosen HR; Corless CL; Rabkin J; Chou S; Department of Medicine, Portland Veterans Affairs Medical Center; and Oregon Health Sciences University, 97207, USA.; rosen.hugo_R@portland.va.gov
- BACKGROUND: The envelope glycoprotein gB of human cytomegalovirus ( CMV ) occurs as one of four main genotypes. Some previous studies have proposed a relationship of CMV gB genotype to the frequency of symptomatic infection and
- [Viral lesions of the eye in human immunodeficiency virus infection]
- Vestn Oftalmol. 1998 Sep-Oct;114(5):35-9. Unique Identifier : AIDSLINE MED/99082702
- Krasnov MM; Marchenko NR
- HIV infection destroying cellular immunity system creates prerequisites for herpesvirus involvement of the anterior and posterior segments of the eye. A total of 370 HIV-infected patients were examined. Ocular diseases were detected in 53 (14.35%). The most prevalent conditions were retinal angiopathy (most often with
- Intracellular trafficking and interactions of the HIV-1 Tat protein.
- Virology. 1998 Dec 5;252(1):126-36. Unique Identifier : AIDSLINE MED/99092482
- Stauber RH; Pavlakis GN; Human Retrovirus Section, NCI-FCRDC, Frederick, Maryland; 21702-1201, USA.
- Fusions of the human immunodeficiency virus type 1 (HIV-1) transactivator protein Tat to the green fluorescent protein (GFP) were used to study the intracellular localization, trafficking, and interactions of Tat in human cells. Tagging Tat with GFP did not change its nuclear localization or ability to act as a transa
- Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state.
- Virology. 1998 Dec 5;252(1):189-99. Unique Identifier : AIDSLINE MED/99092487
- Petropoulos L; Hiscott J; Terry Fox Molecular Oncology Group, Lady Davis Institute for; Medical Research, Sir Mortimer B. Davis-Jewish General Hospital,; Montreal, Quebec, Canada.
- Biological, molecular, and epidemiological data have demonstrated that human T cell leukemia virus type 1 (HTLV-1) encoded Tax protein plays a central role in the initiation of T cell malignancy. The 40-kDa Tax oncoprotein serves as a potent transcriptional activator that induces viral gene expression driven by the HT
- Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor.
- Virology. 1998 Dec 5;252(1):210-7. Unique Identifier : AIDSLINE MED/99092489
- Popik W; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21231, USA. wpopik@jhmi.edu
- We have shown that the binding of simian immunodeficiency virus (SIV) to Jurkat T cells expressing CD4 receptor strongly induces mitogen-activated protein (MAP) kinase kinase (MEK) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) and only weakly induces p38 MAP kinase and c-Jun N-terminal kinase (JNK). Simi
- Gag protein from human immunodeficiency virus type 1 assembles in the absence of cyclophilin A.
- Virology. 1998 Dec 5;252(1):228-34. Unique Identifier : AIDSLINE MED/99092491
- Streblow DN; Kitabwalla M; Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison 53706, USA.
- Human immunodeficiency virus type 1 (HIV-1) replication requires coordinated activities of host and viral factors. We reported previously that interactions of the host factor cyclophilin A with HIV-1 Gag polyproteins affected Gag processing and maturation of virus particles (Streblow et al., 1998. Virology 245, 197-20
- B cells malignantly transformed by human immunodeficiency virus are polyclonal.
- Unique Identifier : AIDSLINE GENBANK/AF096271
- Rodriguez-Alfageme C; Chen Z; Sonoda G; Testa JR; Damiani RD; Astrin SM; Institute for Cancer Research, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111, USA. CR_Alfageme@fccc.edu
- The roles that human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) play in the genesis of acquired immune deficiency syndrome (AIDS)-related lymphomas are not understood. A human B cell line (B-HIV), developed to study AIDS-related lymphomagenesis, contains EBV and HIV genomes and is malignantly transforme
- Mucosal immunisation with papillomavirus virus-like particles elicits systemic and mucosal immunity in mice.
- Virology. 1998 Dec 5;252(1):39-45. Unique Identifier : AIDSLINE MED/99092474
- Liu XS; Abdul-Jabbar I; Qi YM; Frazer IH; Zhou J; Centre for Immunology and Cancer Research, University of; Queensland, Princess Alexandra Hospital, Brisbane, Australia.
- It has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus can induce VLP-specific humoral and cellular immune responses following parenteral administration. To test whether mucosal administration of bovine papillomavirus type 1 (BPV1) VLPs could produce mucosal as well as systemic imm
- Importance of the intracytoplasmic domain of the simian immunodeficiency virus (SIV) envelope glycoprotein for pathogenesis.
- Virology. 1998 Dec 5;252(1):9-16. Unique Identifier : AIDSLINE MED/99092470
- Luciw PA; Shaw KE; Shacklett BL; Marthas ML; Department of Medical Pathology, University of California, Davis; 95616, USA.
- SIVmac1A11 and SIVmac239 are nonpathogenic and pathogenic molecular clones in rhesus macaques, respectively. Although these viruses exhibit approximately 98% nucleotide and amino acid sequence homology, differences are found in the length of the translation frames for several genes. SIVmac239 has a premature stop codo
- The inhibitory effect of RANTES on the infection of primary macrophages by R5 human immunodeficiency virus type-1 depends on the macrophage activation state.
- Virology. 1998 Dec 5;252(1):96-105. Unique Identifier : AIDSLINE MED/99092479
- Amzazi S; Ylisastigui L; Bakri Y; Rabehi L; Gattegno L; Parmentier M; Gluckman JC; Benjouad A; Laboratoire de Biochimie, Faculte des Sciences, Rabat, Morocco.
- We investigated whether culture conditions could affect the RANTES antiviral effect on human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages. Monocyte-derived macrophages (MDM) were obtained either as (1) the adherent cells of 5-day cultures of blood mononuclear cells (PBMC), followed by 2 days
- Usefulness of molecular detection of hum