Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
Characterization of rash with indinavir in a national patient cohort.
Ann Pharmacother. 1999 Jan;33(1):17-21. Unique Identifier : AIDSLINE MED/99138326 Gajewski LK; Grimone AJ; Melbourne KM; Vanscoy GJ; Managed Health Care Division, Stadtlanders Pharmacy, Pittsburgh,; PA 15235, USA.
Abstract:
OBJECTIVE: To characterize indinavir-associated rash using systematic data collection through postmarketing surveillance in a sample of HIV/AIDS patients. DESIGN: HIV-infected patients identified through a medication counseling line who reported onset of a rash following initiation of indinavir therapy were included in this case series analysis. Pertinent information regarding onset, description, and management of rash; other medications initiated within two weeks of indinavir or rash onset; and medication allergy history was obtained through follow-up telephone contact. Patients were contacted weekly until the rash resolved or indinavir was discontinued. SETTING: Stadtlanders Drug Distribution Company, located in Pittsburgh, PA. RESULTS: Of the 110 patients identified and followed, 67% reported rash onset within two weeks of initiating indinavir therapy. The rash was initially localized in all 110 patients and subsequently spread to other areas of the body in 77% of the patients. The rash spread to the full body in 44% (49) of the patients. The rash was accompanied by pruritus in 86% of the patients, and the majority of patients (87%) were afebrile. Eighty-one patients received treatment with medications such as antihistamines or oral or topical corticosteroids. Fifty percent of patients receiving treatment for the rash reported that these medications were helpful in relieving rash symptoms. Fifty-nine percent of the patients continued indinavir therapy despite the occurrence of rash. CONCLUSIONS: Results from this study suggest that indinavir-associated rash occurs within two weeks of initiation of therapy for the majority of patients. Typically, the rash is localized with subsequent spread and is associated with pruritus. The majority of patients are able to continue indinavir therapy despite the occurrence of rash.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/DRUG THERAPY Adolescence Adult Adverse Drug Reaction Reporting Systems Aged Anti-HIV Agents/*ADVERSE EFFECTS/THERAPEUTIC USE Exanthema/*CHEMICALLY INDUCED Female Human Indinavir/*ADVERSE EFFECTS/THERAPEUTIC USE Male Middle Age 990630
A9960990
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Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.
