Psychoactive drug use and progression of HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Psychoactive drug use and progression of HIV infection.

J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):272-4. Unique Identifier : AIDSLINE MED/99174794
Des Jarlais DC; Beth Israel Medical Center, New York City, New York 10003, USA.

Abstract: Early in the history of the AIDS epidemic there was clear evidence of differences in the outcomes of HIV infection between injecting drug users and men who have sex with men. There were also some indications that high levels of nonsterile drug injection may increase the progression of HIV infection. Recent epidemiologic studies indicate no differences in rates of progression to AIDS among drug injectors, men who have sex with men, or persons infected through heterosexual contact. In vitro and animal studies suggest that the effects of different psychoactive drugs on HIV infection may be negative, positive, or mixed, and that the effects of a psychoactive drug on immune functioning may differ among acute administration, chronic administration, or cessation of chronic administration. Although the current epidemiologic data do not provide support for the hypothesis that psychoactive drug use will have any important effects on the course of HIV infection, possible interactions between psychoactive drugs and antiviral medications and medication adherence issues among drug users are important areas for AIDS research. Relations between psychoactive drug use, the nervous system, and the immune system are a promising area for basic research.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Disease Progression Human HIV Infections/*PHYSIOPATHOLOGY Male Psychotropic Drugs/*PHARMACOLOGYKWDjournalarticlereviewreview,tutorialanimaldiseaseprogressionhumanhivinfections/KWDphysiopathologymalepsychotropicdrugs/KWDpharmacology
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A9960974

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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