Increased expression of regeneration and tolerance factor in individuals with human immunodeficiency virus infection.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Increased expression of regeneration and tolerance factor in individuals with human immunodeficiency virus infection.

Clin Diagn Lab Immunol. 1999 Mar;6(2):193-8. Unique Identifier : AIDSLINE MED/99167664
DuChateau BK; Lee GW; Westerman MP; Beaman KD; Clinical Immunology Laboratory and Department of; Microbiology/Immunology, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, Illinois 60064, USA.

Abstract: Regeneration and tolerance factor (RTF) plays a pivotal role in successful pregnancy outcome and has potent immunomodulating properties. During pregnancy, it is abundantly expressed in the placenta and on peripheral B lymphocytes. Several lines of evidence suggest that both successful pregnancy outcome and progression from human immunodeficiency virus (HIV) infection to AIDS are associated with a Th2-type response. As a result, we hypothesized that the cellular expression of RTF may also be increased during infection with HIV. Using flow cytometric analysis, we showed a significantly (P < 0.01) increased expression of RTF on CD3(+) cells obtained from individuals with HIV over that for individuals without HIV. On average, 32.1% of the CD3(+) cells from individuals with HIV expressed high levels of RTF. In contrast, an average of only 6.7% of the CD3(+) cells from individuals without HIV expressed high levels of RTF. Similar results were obtained when CD19(+) cells from individuals with (mean, 44.1%) and without (mean, 25.8%) HIV were evaluated. Linear regression analysis suggested that high levels of RTF expression by CD3(+) cells correlated better with viral load (r value, 0.46) than with absolute CD4 count (r value, 0.09). While additional experiments are necessary to delineate the precise immunologic role of RTF, our current data suggest that RTF expression during HIV infection may be a useful marker of immune activation.

Keywords: JOURNAL ARTICLE Antibodies, Monoclonal Antibodies, Viral/ANALYSIS Antibody Specificity Antigens, CD19/ANALYSIS Antigens, CD3/ANALYSIS CD4-Positive T-Lymphocytes/CHEMISTRY/IMMUNOLOGY/*VIROLOGY CD8-Positive T-Lymphocytes/CHEMISTRY/IMMUNOLOGY/*VIROLOGY Female Flow Cytometry Fluorescein-5-isothiocyanate Human HIV Infections/*IMMUNOLOGY Linear Models Pregnancy Pregnancy Proteins/ANALYSIS/*IMMUNOLOGY
990630
A9960964

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