Synthesis of a new class of HIV-1 inhibitors.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Synthesis of a new class of HIV-1 inhibitors.

Nucleosides Nucleotides. 1999 Feb;18(2):263-75. Unique Identifier : AIDSLINE MED/99166248
Farese-Di Giorgio A; Pairot S; Patino N; Condom R; Di Giorgio C; Aumelas A; Aubertin AM; Guedj R; Laboratoire de Chimie Bio-Organique, CNRS ESA 6001, Universite; de Nice Sophia-Antipolis, France.

Abstract: A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without cellular toxicity until 200 microM concentration.

Keywords: JOURNAL ARTICLE Anti-HIV Agents/*CHEMICAL SYNTHESIS Arginine/ANALOGS & DERIVATIVES Gene Products, tat/GENETICS HIV Long Terminal Repeat/GENETICS HIV-1/DRUG EFFECTS HIV-2/DRUG EFFECTS Molecular Structure Nucleic Acid Conformation Nucleotides/*CHEMICAL SYNTHESIS/PHARMACOLOGY Peptide Nucleic Acids/*CHEMICAL SYNTHESIS/PHARMACOLOGY RNA-Binding Proteins/GENETICS RNA, Viral/GENETICS Support, Non-U.S. Gov't
990630
A9960950

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