C1q autoantibodies in HIV infection: correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

C1q autoantibodies in HIV infection: correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins.

1999 Feb;90(2):247-55. Unique Identifier : AIDSLINE MED/99180797
Prohaszka Z; Daha MR; Susal C; Daniel V; Szlavik J; Banhegyi D; Nagy K; Varkonyi V; Horvath A; Ujhelyi E; Toth FD; Uray K; Hudecz F; Fust G; Third Department of Medicine, Semmelweis Medical University,; Budapest, Hungary.

Abstract: Antibodies to solid phase C1q (C1qAb) were determined in 295 serum samples from 132 HIV-infected subjects and in sera from 140 HIV-seronegative healthy individuals as control. An ELISA method applied for the determination of C1qAb in other diseases was used. In part of these sera, other autoantibodies (antibodies reacting with 60-kDa human heat shock protein (hsp60) or mycobacterial hsp65; IgA and IgG class antibodies against the Fab and F(ab')2 moieties of IgG) as well as complement-mediated antibody-dependent enhancement/neutralization (C'-ADE) were also determined. Increased amount of C1qAb was found in HIV-infected subjects as compared with HIV-seronegative controls (P = 0.0138). In 17 of 132 (13.0%) seropositive individuals but only in 7/140 (5.0%) samples from the controls, the amount of C1qAb exceeded the upper limit (95th percentile) of the normal values (P = 0.031). The amount of C1qAb significantly decreased during a follow-up period of 65 months. C1qAb levels were found to strongly correlate to hsp60/65 autoantibodies but did not correlate or only weakly correlated to the amount of anti-Fab or anti-F(ab')2 autoantibodies measured in the same serum samples. Anti-C1q antibodies recognized the solid phase hsp60/65. Three predicted epitope regions of M. paratuberculosis hsp65 were able to bind efficiently C1q antibodies. An inverse correlation was found between C1qAb and C'-ADE, neutralization was more frequent in the sera with detectable C1qAb, whereas sera without C1qAb more likely enhanced HIV infection in vitro. Copyright 1999 Academic Press.

Keywords: JOURNAL ARTICLE Antigens, Bacterial Autoantibodies/*BLOOD Autoantigens Binding Sites Case-Control Studies Chaperonin 60/*IMMUNOLOGY Chaperonins/IMMUNOLOGY Complement 1q/*IMMUNOLOGY Enzyme-Linked Immunosorbent Assay Epitope Mapping Human HIV Infections/*IMMUNOLOGY HIV Seronegativity/IMMUNOLOGY Longitudinal Studies Mycobacterium paratuberculosis/IMMUNOLOGY Prognosis Support, Non-U.S. Gov't
990630
A9960945

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