Enhancement by vasoactive intestinal peptide of gamma-interferon production by antigen-stimulated type 1 helper T cells. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Enhancement by vasoactive intestinal peptide of gamma-interferon production by antigen-stimulated type 1 helper T cells.

Unique Identifier : AIDSLINE MED/99138717
Jabrane-Ferrat N; Bloom D; Wu A; Li L; Lo D; Sreedharan SP; Turck CW; Goetzl AE; Departments of Medicine and Microbiology-Immunology, University; of California Medical Center, San Francisco, California; 94143-0711, USA.

Abstract: Vasoactive intestinal peptide (VIP) is a neuroendocrine mediator in immune tissues that affects many T cell functions through two homologous high-affinity G-protein-coupled receptors, termed VIPR1 and VIPR2. Antigen-stimulated secretion of gamma-interferon (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA/2 mouse I-Ed-restricted clones, which express VIPR1 and VIPR2, was enhanced by 10(-10) M to 10(-7) M VIP. Enhancement of IFN-gamma secretion reached a mean maximum of fourfold for VIP and threefold for a VIPR2-selective agonist, without any effect of a VIPR1-selective agonist. Secretion of IFN-gamma by PMA and ionomycin-stimulated clones of Th1 cells was not altered by VIP. Antigen-stimulated secretion of IFN-gamma by T cell receptor-transgenic, influenza hemagglutinin-specific, and cytokine-differentiated mouse lymph node Th1 cells, which also express VIPR1 and VIPR2, was enhanced by 10(-10) M to 10(-8) M VIP. Enhancement of IFN-gamma secretion increased to a maximum of 14-fold for VIP, 14-fold for the VIPR2-selective agonist, and 20-fold for the VIPR1-selective agonist. In contrast to VIP suppression of interleukin production and lack of effect on IFN-gamma production by T cells stimulated with anti-CD3 antibody or a mitogenic lectin, generation of IFN-gamma by antigen-stimulated T cells is enhanced significantly by physiological concentrations of VIP.
Keywords: JOURNAL ARTICLE Animal Antigen Presentation Antigens Female Interferon Type II/*BIOSYNTHESIS/IMMUNOLOGY Lymphocyte Transformation Mice Mice, Inbred BALB C Receptors, Vasoactive Intestinal Peptide/METABOLISMKWDjournalarticleanimalantigenpresentationantigensfemaleinterferontypeii/KWDbiosynthesis/immunologylymphocytetransformationmicemice,inbredbalbcreceptors,vasoactiveintestinalpeptide/metabolism
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Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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