Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons.

J Infect Dis. 1999 Mar;179(3):538-47. Unique Identifier : AIDSLINE MED/99137788
Bernard NF; Yannakis CM; Lee JS; Tsoukas CM; Immunodeficiency Treatment Center, McGill University Hospital; Center, Montreal General Hospital, Montreal, Quebec, H3G 1A4,; Canada. mctl@musica.mcgill.ca

Abstract: Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus-specific memory cytotoxic T lymphocytes (CTL). None had the Delta32CCR-5/Delta32CCR-5 genotype associated with HIV resistance. HIV-specific CTL were detected in 7 (41.1%) of 17 exposed uninfected subjects versus 0 of 14 seronegative subjects with no HIV risk factors (P=.006, chi2 test). Recognition of virus by CTL in exposed uninfected subjects was major histocompatibility complex class I-restricted and multispecific, and specificity could change with time. Activity could persist up to 34 months after the last virus exposure. The presence of HIV-specific CTL in a greater proportion of seronegative HIV-exposed versus unexposed subjects supports the notion that in some cases, virus exposure induces HIV immunity without seroconversion or disease progression.
Keywords: JOURNAL ARTICLE Adult Cytotoxicity, Immunologic Female Genotype Histocompatibility Testing Human HIV/GENETICS/*IMMUNOLOGY HIV Seronegativity/*GENETICS/*IMMUNOLOGY Immunity, Natural Major Histocompatibility Complex Male Middle Age Needlestick Injuries Receptors, CCR5/*GENETICS Sex Behavior Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/*IMMUNOLOGYKWDjournalarticleadultcytotoxicity,immunologicfemalegenotypehistocompatibilitytestinghumanhiv/genetics/KWDimmunologyhivseronegativity/KWDgenetics/KWDimmunologyimmunity,naturalmajorhistocompatibilitycomplexmalemiddleageneedlestickinjuriesreceptors,ccr5/KWDgeneticssexbehaviorsupport,non-uKWDsKWDgov'tt-lymphocytes,cytotoxic/KWDimmunology
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