1999
- Isolation of high-molecular-weight genomic DNA from intact biohazardous mammalian tissues.
- Biotechniques. 1999 Jan;26(1):62-4, 66. Unique Identifier : AIDSLINE MED/99111964
- Liska V; Ruprecht RM; Dana-Farber Cancer Institute, Boston, MA 02115-6084, USA.
- Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets.
- Br J Haematol. 1999 Feb;104(2):220-9. Unique Identifier : AIDSLINE MED/99157988
- Kowalska MA; Ratajczak J; Hoxie J; Brass LF; Gewirtz A; Poncz M; Ratajczak MZ; The Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
- Thrombocytopenia is a late complication of human immunodeficiency virus (HIV) infection. The chemokine receptor CXCR4 has been shown to be a co-receptor for lymphocyte-tropic HIV-1 strains. CXCR4 is also a natural receptor for the chemokine SDF-1. We have previously shown that CXCR1 and CXCR2 are present on megakaryoc
- [Characteristics of the carriers of antibodies to hepatitis C virus with normal transaminases levels in HIV infected patients]
- An Med Interna. 1998 Sep;15(9):459-63. Unique Identifier : AIDSLINE MED/99179252
- Ramos Paesa C; Pascual Catalan A; Arazo Garces P; Aguirre Errasti JM; Hermida Lazcano I; Servicio de Medicina Interna, Hospital Miguel Servet, Zaragoza.
- BACKGROUND: To know the characteristics of the carriers of antibodies to hepatitis C virus (HCV) with persistently normal transaminases levels ( carriers ) in coinfected with HIV, the incidence of the real viral activity and the factors that could determine it. PATIENTS AND METHODS: We analyzed 114 patients with crite
- [Viremia levels of the chronic hepatitis c virus in HIV infected patients, clinical implications]
- Unique Identifier : AIDSLINE MED/99179253
- Ramos Paesa C; Pascual Catalan A; Arazo Garces P; Aguirre Errasti JM; Lasierra P
- BACKGROUND: To know the clinical implications of the viremia level and its evolution in time of the hepatitis C virus (HCV) in patients with chronic hepatitis and infected with the Human Immunodeficiency Virus (HIV). PATIENTS AND METHODS: We have studied the viremia level of the HCV in a a 38 patients group with activ
- [Pulmonary lymphomatoid granulomatosis associated with AIDS. Report of a case and review of the literature]
- An Med Interna. 1998 Sep;15(9):487-9. Unique Identifier : AIDSLINE MED/99179259
- Pastrana Delgado J; Conchillo Armendariz MA; Vega Vazquez F; Beloqui Ruiz O; Departamento de Medicina Interna, Clinica Universitaria de; Navarra, Pamplona.
- We present an AIDs patient who was admitted to our hospital because of dry cough, pleuritic chest pain, fever and bilateral lung nodules on the chest X-ray. An open lung biopsy was diagnostic for Lymphomatoid Granulomatosis (GL). We review the literature of the clinical manifestations, anatomopathological and pathogen
- [Pulmonary infection by Mycobacterium xenopi in a patient with positive HIV (letter)]
- An Med Interna. 1998 Sep;15(9):506-7. Unique Identifier : AIDSLINE MED/99179263
- Alberola ML; Roig P; Orti A; Martin C; Cuadrado JM; Merino J
- [Virologic levels for HIV before and after the introduction of protease inhibitors (letter)]
- An Med Interna. 1998 Sep;15(9):508-9. Unique Identifier : AIDSLINE MED/99179265
- Molinero M; Solano C; Gomez-Cano M; Soriano V
- Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals.
- Blood. 1999 Mar 15;93(6):1838-42. Unique Identifier : AIDSLINE MED/99168970
- Rabkin CS; Yang Q; Goedert JJ; Nguyen G; Mitsuya H; Sei S; Viral Epidemiology Branch, HIV and AIDS Malignancy Branch, and; Experimental Retrovirology Section, National Cancer Institute,; Bethesda, MD, USA.
- Normal B-lymphocyte maturation and proliferation are regulated by chemotactic cytokines (chemokines), and genetic polymorphisms in chemokines and chemokine receptors modify progression of human immunodeficiency virus-1 (HIV-1) infection. Therefore, 746 HIV-1-infected persons were examined for associations of previousl
- Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.
- Blood. 1999 Mar 15;93(6):1843-50. Unique Identifier : AIDSLINE MED/99168971
- Hori K; Burd PR; Furuke K; Kutza J; Weih KA; Clouse KA; Division of Cytokine Biology and the Division of Cellular and; Gene Therapies, Center for Biologics Evaluation and Research,; Food and Drug Administration, Rockville, MD, USA.
- Nitric oxide (NO) plays an important role in normal neural cell function. Dysregulated or overexpression of NO contributes to neurologic damage associated with various pathologies, including human immunodeficiency virus (HIV)-associated neurological disease. Previous studies suggest that HIV-infected monocyte-derived
- Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells.
- Blood. 1999 Mar 15;93(6):1851-7. Unique Identifier : AIDSLINE MED/99168972
- Mengozzi M; De Filippi C; Transidico P; Biswas P; Cota M; Ghezzi S; Vicenzi E; Mantovani A; Sozzani S; Poli G; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milano, Italy.
- We have recently described a significant correlation between human immunodeficiency virus-1 (HIV-1) RNA replication and monocyte chemotactic protein-1 (MCP-1) levels in the cerebrospinal fluid (CSF) of individuals with the acquired immunodeficiency syndrome (AIDS) with HIV encephalitis (E). Because local macrophages (
- Transduction of primitive human marrow and cord blood-derived hematopoietic progenitor cells with adeno-associated virus vectors.
- Blood. 1999 Mar 15;93(6):1882-94. Unique Identifier : AIDSLINE MED/99168976
- Chatterjee S; Li W; Wong CA; Fisher-Adams G; Lu D; Guha M; Macer JA; Forman SJ; Wong KK Jr; Division of Pediatrics, Department of Hematology and Bone Marrow; Transplantation, City of Hope National Medical Center, Duarte,; CA, USA. schatterjee@coh.org
- We evaluated the capacity of adeno-associated virus (AAV) vectors to transduce primitive human myeloid progenitor cells derived from marrow and cord blood in long-term cultures and long-term culture-initiating cell (LTC-IC) assays. Single-colony analyses showed that AAV vectors transduced CD34(+) and CD34(+)38(-) clon
- Human immunodeficiency virus type 1 Vpr alters bone marrow cell function.
- Blood. 1999 Mar 15;93(6):1906-15. Unique Identifier : AIDSLINE MED/99168978
- Kulkosky J; Laptev A; Shetty S; Srinivasan A; BouHamdan M; Prockop DJ; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Jefferson University, Philadelphia,; PA, USA.
- Vpr, a 96 amino acid protein, encoded by the human immunodeficiency virus type I (HIV-1), is important for efficient infection of mononuclear phagocytic cells. These cells are abundant in whole bone marrow, which can easily be cultured in vitro to support hematopoiesis. Our experiments indicate that Vpr plays a role i
- CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells.
- Blood. 1999 Mar 15;93(6):1992-2002. Unique Identifier : AIDSLINE MED/99168987
- Buhmann R; Nolte A; Westhaus D; Emmerich B; Hallek M; Laboratorium fur Molekulare Biologie, Genzentrum, Medizinische; Klinik, Grobetahadern, Ludwig-Maximilians-Universitat, Munchen,; Germany.
- Although spontaneous remissions may rarely occur in B-cell chronic lymphocytic leukemia (B-CLL), T cells do generally not develop a clinically significant response against B-CLL cells. Because this T-cell anergy against B-CLL cells may be caused by the inability of B-CLL cells to present tumor-antigens efficiently, we
- The nucleoporin nup153 plays a critical role in multiple types of nuclear export.
- Mol Biol Cell. 1999 Mar;10(3):649-64. Unique Identifier : AIDSLINE MED/99169012
- Ullman KS; Shah S; Powers MA; Forbes DJ; Department of Biology, University of California at San Diego, La; Jolla, California 92093-0347, USA. katharine.ullman@hci.utah.edu
- The fundamental process of nucleocytoplasmic transport takes place through the nuclear pore. Peripheral pore structures are presumably poised to interact with transport receptors and their cargo as these receptor complexes first encounter the pore. One such peripheral structure likely to play an important role in nucl
- Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.
- Mol Biol Cell. 1999 Mar;10(3):677-91. Unique Identifier : AIDSLINE MED/99169014
- Pitcher C; Honing S; Fingerhut A; Bowers K; Marsh M; Medical Research Council Laboratory for Molecular Cell Biology; and Department of Biochemistry, University College London, London; WC1E 6BT, United Kingdom.
- Cluster of differentiation antigen 4 (CD4), the T lymphocyte antigen receptor component and human immunodeficiency virus coreceptor, is down-modulated when cells are activated by antigen or phorbol esters. During down-modulation CD4 dissociates from p56(lck), undergoes endocytosis through clathrin-coated pits, and is
- Riluzole: a potential therapy for HIV dementia? [letter]
- Ann Pharmacother. 1999 Jan;33(1):114-5. Unique Identifier : AIDSLINE MED/99138345
- McKinley GF
- Characterization of rash with indinavir in a national patient cohort.
- Ann Pharmacother. 1999 Jan;33(1):17-21. Unique Identifier : AIDSLINE MED/99138326
- Gajewski LK; Grimone AJ; Melbourne KM; Vanscoy GJ; Managed Health Care Division, Stadtlanders Pharmacy, Pittsburgh,; PA 15235, USA.
- OBJECTIVE: To characterize indinavir-associated rash using systematic data collection through postmarketing surveillance in a sample of HIV/AIDS patients. DESIGN: HIV-infected patients identified through a medication counseling line who reported onset of a rash following initiation of indinavir therapy were included i
- Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia.
- Intern Med. 1998 Dec;37(12):1019-22. Unique Identifier : AIDSLINE MED/99129412
- Amenomori M; Umemoto T; Kushima R; Hattori T; Ryuo Medical Center Yuge Clinic, Gamogun, Shiga.
- A 54-year-old woman came to our office because of pretibial edema. She had no gastrointestinal symptoms. Laboratory tests revealed severe hypoproteinemia. Upper gastrointestinal endoscopy demonstrated enlarged gastric folds and multiple aphthoid nodules on the body and the fornix of the stomach. The biopsy specimen re
- An almost-intact human endogenous retrovirus K on human chromosome 7 [letter]
- Nat Genet. 1999 Mar;21(3):257-8. Unique Identifier : AIDSLINE MED/99178257
- Mayer J; Sauter M; Racz A; Scherer D; Mueller-Lantzsch N; Meese E
- Human immunodeficiency virus and the outcome of treatment for new and recurrent pulmonary tuberculosis in African patients.
- Am J Respir Crit Care Med. 1999 Mar;159(3):733-40. Unique Identifier : AIDSLINE MED/99160777
- Murray J; Sonnenberg P; Shearer SC; Godfrey-Faussett P; National Centre for Occupational Health, Department of Health,; Johannesburg, South Africa. jmurray@ncoh.pwv.gov.za
- The purpose of this study was to evaluate the impact of human immunodeficiency virus (HIV) infection on treatment for tuberculosis (TB). The study population comprised 28,522 black Southern African gold miners. Patients with sputum culture-positive new or recurrent pulmonary TB diagnosed in 1995 were prospectively enrv
- An open and closed case for all polymerases.
- Structure. 1999 Feb 15;7(2):R31-5. Unique Identifier : AIDSLINE MED/99148132
- Doublie S; Sawaya MR; Ellenberger T; Department of Microbiology and Molecular Genetics, The Markey; Center for Molecular Genetics, University of Vermont, Burlington,; VT 05405, USA.
- The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer-template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic cv
- Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.
- Structure. 1999 Feb 15;7(2):131-42. Unique Identifier : AIDSLINE PDB/2F58
- Stanfield R; Cabezas E; Satterthwait A; Stura E; Profy A; Wilson I; The Scripps Research Institute, Department of Molecular Biology,; 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
- BACKGROUND: The third hypervariable (V3) loop of HIV-1 gp120 has been termed the principal neutralizing determinant (PND) of the virus and is involved in many aspects of virus infectivity. The V3 loop is required for viral entry into the cell via membrane fusion and is believed to interact with cell surface chemokine v
- Biologically active oligodeoxyribonucleotides. Part 11: The least phosphate-modification of quadruplex-forming hexadeoxyribonucleotide TGGGAG, bearing 3-and 5-end-modification, with anti-HIV-1 activity.
- Bioorg Med Chem. 1998 Dec;6(12):2469-75. Unique Identifier : AIDSLINE MED/99122712
- Koizumi M; Koga R; Hotoda H; Ohmine T; Furukawa H; Agatsuma T; Nishigaki T; Abe K; Kosaka T; Tsutsumi S; Sone J; Kaneko M; Kimura S; Shimada K; Exploratory Chemistry Research Lab., Sankyo Co., Ltd, Tokyo,; Japan. koizum@shina.sankyo.co.jp
- We have found that a hexadeoxyribonucleotide (5 TGGGAG3 , R-95288), Koizumi, M. et al. Bioorganic & Medicinal Chemistry, 1997, 5, 2235, bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5 -end and a 2-hydroxyethylphosphate at the 3 -end, has high anti-HIV-1 activity and the least cytotoxicity in vitro and in v
- The pattern of neurotransmitter alterations in LP-BM5 infected mice is consistent with glutamatergic hyperactivation.
- Brain Res. 1998 May 18;793(1-2):119-26. Unique Identifier : AIDSLINE MED/98296129
- Kustova Y; Ha JH; Espey MG; Sei Y; Morse D; Basile AS; Laboratory of Bio-Organic Chemistry, NIDDK, National Institutes; of Health, Bethesda, MD 20892, USA.
- To gain insight into the neurochemical pathologies contributing to AIDS dementia complex, neurotransmitter levels were measured in the brains of mice infected with the LP-BM5 leukemia retrovirus. These mice develop immunologic and cognitive deficits analogous to human HIV-1 infecti
- Oxandrolone, used for treatment of wasting disease in HIV-1-infected patients, does not diminish the antiviral activity of deoxynucleoside analogues in lymphocyte and macrophage cell cultures.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):215-9. Unique Identifier : AIDSLINE MED/99174786
- Segal DM; Perez M; Shapshak P; Department of Psychiatry and Behavioral Sciences, Comprehensive; Drug Research Center, University of Miami School of Medicine,; Florida 33136, USA.
- Antiviral agents are the primary therapy for patients infected with HIV-1. However, supportive therapies are often necessary in addition to antiviral drugs because of the devastating wasting process associated with HIV-1 infection and AIDS. Oxandrolone, an anabolic steroid, is used in promoting weight gain and, most i
- Clinical trials using HIV-1 RNA-based primary endpoints: statistical analysis and potential biases.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):220-7. Unique Identifier : AIDSLINE MED/99174787
- Marschner IC; Betensky RA; DeGruttola V; Hammer SM; Kuritzkes DR; Center for Biostatistics in AIDS Research and Department of; Biostatistics, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.
- Clinical trial endpoints based on magnitude of reduction in HIV-1 RNA levels provide an important complement to endpoints based on percentage of patients achieving complete virologic suppression. However, interpretation of magnitude of reduction can be biased by measurement limitations of virologic assays, particularl
- Studies of body composition and fat distribution in HIV-infected and control subjects.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):228-37. Unique Identifier : AIDSLINE MED/99174788
- Kotler DP; Rosenbaum K; Wang J; Pierson RN; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; Columbia University College of Physicians and Surgeons, New York,; New York 10025, USA.
- OBJECTIVE: Recent studies have documented alterations in body fat distribution that have been associated with protease inhibitor therapy. We compared body composition, including measurements of fat distribution, in 96 HIV-infected subjects studied since January 1996 (current HIV), subjects seen prior to January 1996 (
- Stability of cutaneous anergy in women with or at risk for HIV infection. HIV Epidemiology Research Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):238-44. Unique Identifier : AIDSLINE MED/99174789
- Klein RS; Sobel J; Flanigan T; Smith D; Margolick JB; Department of Medicine, Montefiore Medical Center and Albert; Einstein College of Medicine, Bronx, New York 10467, USA.
- OBJECTIVE: To study the stability of cutaneous anergy in women with or at risk for HIV infection. DESIGN: Prospective multicenter cohort study METHODS: Interviews, CD4+ lymphocyte counts, and intradermal skin testing with mumps, Candida, and tetanus toxoid antigens were performed on two occasions at a median interval
- Phase II, randomized, open-label, community-based trial to compare the safety and activity of combination therapy with recombinant interferon-alpha2b and zidovudine versus zidovudine alone in patients with asymptomatic to mildly symptomatic HIV infection. HIV Protocol C91-253 Study Team.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):245-54. Unique Identifier : AIDSLINE MED/99174790
- Krown SE; Aeppli D; Balfour HH Jr; Department of Medicine, Memorial Sloan-Kettering Cancer Center; and Cornell University Medical College, New York, New York 10021,; USA.
- OBJECTIVES: To compare, in a community-based therapeutic setting, the safety, tolerance, and efficacy of combination therapy with recombinant interferon-alpha2b (rIFN-alpha2b) and zidovudine (ZDV) to ZDV monotherapy. DESIGN: Open-label, two-armed, randomized study. PAT
- Lack of association between hepatitis C infection and development of AIDS-related lymphoma.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):255-8. Unique Identifier : AIDSLINE MED/99174791
- Levine AM; Nelson R; Zuckerman E; Zuckerman T; Govindarajan S; Valinluck B; Bernstein L; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033, USA. hornor@hsc.usc.edu
- Hepatitis C virus (HCV) has been associated with various lymphoproliferative disorders, and a high prevalence (9%-32%) of chronic HCV infection has been demonstrated among patients with lymphoma. Dual coinfection by HIV and HCV has been demonstrated in approximately 40% of certain populations of HIV-infected individua
- HIV infection of the central nervous system is characterized by rapid turnover of viral RNA in cerebrospinal fluid.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):259-64. Unique Identifier : AIDSLINE MED/99174792
- Eggers CC; van Lunzen J; Buhk T; Stellbrink HJ; Neurologische Klinik, Universitatskrankenhaus Eppendorf,; Hamburg, Germany. eggers@uke.uni-hamburg.de
- To assess the kinetics of viral replication and decay in cerebrospinal fluid (CSF), we studied the short-term effects of highly active antiretroviral therapy (HAART) on CSF HIV-1 RNA concentrations. In 15 HIV-positive patients, HIV RNA concentrations were measured in paired CSF and plasma/serum samples. Samples were o
- Impact of tuberculosis on the body composition of HIV-infected men in Brazil.
- Unique Identifier : AIDSLINE MED/99174793
- Paton NI; Castello-Branco LR; Jennings G; Ortigao-de-Sampaio MB; Elia M; Costa S; Griffin GE; St. George's Hospital Medical School, Tooting, London, UK.; Paton_NIJ@notes.ttsh.gov.sg
- OBJECTIVE: Tuberculosis (TB) is the commonest HIV-related opportunistic infection in many developing countries and is thought to be a frequent underlying cause of HIV-associated wasting. We have used reference water dilution methods to examine the body composition changes associated with TB and to assess the severity
- Psychoactive drug use and progression of HIV infection.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):272-4. Unique Identifier : AIDSLINE MED/99174794
- Des Jarlais DC; Beth Israel Medical Center, New York City, New York 10003, USA.
- Early in the history of the AIDS epidemic there was clear evidence of differences in the outcomes of HIV infection between injecting drug users and men who have sex with men. There were also some indications that high levels of nonsterile drug injection may increase the progression of HIV infection. Recent epidemiolog
- Direct comparison of time to AIDS and infectious disease death between HIV seroconverter injection drug users in Italy and the United States: results from the ALIVE and ISS studies. AIDS Link to Intravenous Experiences. Italian Seroconversion Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):275-82. Unique Identifier : AIDSLINE MED/99174795
- Pezzotti P; Galai N; Vlahov D; Rezza G; Lyles CM; Astemborski J; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome,; Italy. Patrizio.Pezzotti@iss.it
- OBJECTIVE: To compare the rate of HIV disease progression in a sample of polydrug injectors (AIDS Link to Intravenous Experiences [ALIVE] study) with that in a sample of predominantly opiate injectors (Italian Seroconversion Study [ISS]). DESIGN: Prospective cohort studies of HIV-positive individuals whose date of ser
- Incidence of discontinuation of highly active antiretroviral combination therapy (HAART) and its determinants.
- Unique Identifier : AIDSLINE MED/99174797
- van Roon EN; Verzijl JM; Juttmann JR; Lenderink AW; Blans MJ; Egberts AC
- OBJECTIVE: To determine the incidence and determinants for discontinuation of initial highly active antiretroviral therapy (HAART). DESIGN: In this retrospective follow-up study from hospital files and pharmacy dispensing data, a standard dataset was collected including patient characteristics, therapy characteristics
- Incidence and risk factors for heterosexually acquired HIV in an inner-city cohort of women: temporal association with pregnancy.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):295-9. Unique Identifier : AIDSLINE MED/99174798
- Chirgwin KD; Feldman J; Dehovitz JA; Minkoff H; Landesman SH; Department of Medicine, State University of New York, Health; Sciences Center at Brooklyn, USA.
- BACKGROUND: A growing proportion of AIDS cases in the United States are due to heterosexual transmission of HIV, particularly in women. The risk of heterosexually acquired HIV was prospectively studied in a cohort of inner-city women with no history of parenteral drug use. METHODS: Stu
- Cervical dysplasia on cervicovaginal Papanicolaou smear among HIV-1-infected pregnant and nonpregnant women. Women and Infants Transmission Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):300-7. Unique Identifier : AIDSLINE MED/99174799
- Stratton P; Gupta P; Riester K; Fox H; Zorrilla C; Tuomala R; Eriksen N; Vajaranant M; Minkoff H; Fowler MG; National Institute of Child Health and Human Development,; Bethesda, Maryland 20982-1862, USA. Pamela_Stratton@nih.gov
- OBJECTIVE: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. METHODS: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV-infected women had cyto
- Evaluation of behavioral and social issues among Thai HIV vaccine trial volunteers.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):308-14. Unique Identifier : AIDSLINE MED/99174800
- Thapinta D; Jenkins RA; Celentano DD; Nitayaphan S; Buapunth P; Triampon A; Morgan PA; Khamboonruang C; Suwanarach C; Yutabootr Y; Ruckphaopunt S; Suwankiti S; Tubtong V; Cheewawat W; McNeil JG; Michael RA; Faculty of Nursing, Research Institute of Health Sciences, Chiang; Mai University, Thailand.
- Behavioral and social issues were investigated in phase I/II preventive HIV vaccine trial volunteers in Thailand . These included risk behavior, HIV knowledge, distress, and social experiences associated with trial participation. Data were collected at baseline and at 4- and 8-mon
- Few clues for AIDS vaccines from structural data on gp120 and its receptors and antibodies [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):315-6. Unique Identifier : AIDSLINE MED/99174801
- Kohler H; Muller S; Schiffer M; Nara PL
- Recent dramatic decrease in AIDS cases and HIV-related deaths contrasts with stable rate of new HIV-positive patients detected in Lyon, France, from 1988 to 1997 [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):316-7. Unique Identifier : AIDSLINE MED/99174802
- Vanhems P; Baratin D; Trepo C; Peyramond D; Touraine JL; Marceillac E; Fabry J
- Development of a Western blot assay for detection of bovine immunodeficiency-like virus using capsid and transmembrane envelope proteins expressed from recombinant baculovirus.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):168-72. Unique Identifier : AIDSLINE MED/99167659
- Abed Y; St-Laurent G; Zhang H; Jacobs RM; Archambault D; Departement des Sciences Biologiques, Universite du Quebec a; Montreal, Montreal, Quebec, Canada.
- A 120-amino-acid polypeptide selected from the transmembrane protein region (tTM) and the major capsid protein p26 of bovine immunodeficiency-like virus (BIV) were expressed as fusion proteins from recombinant baculoviruses. The antigenic reactivity of both recombinant fusion proteins was confirmed by Western blot wit
- Protection against influenza virus infection of mice fed Bifidobacterium breve YIT4064.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):186-92. Unique Identifier : AIDSLINE MED/99167663
- Yasui H; Kiyoshima J; Hori T; Shida K; Yakult Central Institute for Microbiological Research and; Department of Microbiology, 1796 Yaho, Kunitachi-shi, Tokyo; 186-8650, Japan.
- Mice fed Bifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral a
- Increased expression of regeneration and tolerance factor in individuals with human immunodeficiency virus infection.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):193-8. Unique Identifier : AIDSLINE MED/99167664
- DuChateau BK; Lee GW; Westerman MP; Beaman KD; Clinical Immunology Laboratory and Department of; Microbiology/Immunology, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, Illinois 60064, USA.
- Regeneration and tolerance factor (RTF) plays a pivotal role in successful pregnancy outcome and has potent immunomodulating properties. During pregnancy, it is abundantly expressed in the placenta and on peripheral B lymphocytes. Several lines of evidence suggest that both successful pregnancy outcome and progression
- A powerful DNA extraction method and PCR for detection of microsporidia in clinical stool specimens.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):243-6. Unique Identifier : AIDSLINE MED/99167672
- Muller A; Stellermann K; Hartmann P; Schrappe M; Fatkenheuer G; Salzberger B; Diehl V; Franzen C; Department of Internal Medicine I, University of Cologne, D-50924; Cologne, Germany.
- The diagnosis of intestinal microsporidiosis has traditionally depended on direct visualization of the parasite in stool specimens or intestinal biopsy samples by light and/or electron microscopy. Limited information about the specificity and sensitivity of PCR for the
- Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):247-53. Unique Identifier : AIDSLINE MED/99167673
- Betensky RA; Calvelli T; Pahwa S; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA. betensky@hsph.harvard.edu
- We investigated the predictive value of CD19 cell percentages (CD19%) for times to bacterial infections, using data from six pediatric AIDS Clinical Trials Group protocols and adjusting for other potentially prognostic variables, such as CD4%, CD8%, immunoglobulin (IgA) level, lymphocyte count, prior infections, prior
- Antenatal screening for HIV in the UK: what is to be done? [editorial]
- J Med Screen. 1998;5(4):170-1. Unique Identifier : AIDSLINE MED/99133408
- Nicoll A
- Performance of antenatal HIV screening strategies in the UK: correction [letter]
- J Med Screen. 1998;5(4):214. Unique Identifier : AIDSLINE MED/99133417
- Tookey P; Gibb D; Ades T
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
- Chem Biol. 1999 Feb;6(2):111-6. Unique Identifier : AIDSLINE MED/99147129
- Marx A; Spichty M; Amacker M; Schwitter U; Hubscher U; Bickle TA; Maga G; Giese B; Department of Chemistry, University of Basel, Switzerland.
- BACKGROUND: To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether conformations obtained in this way appropriately reflect the reactivity of enzymes, however. Rates that characterize tran
- Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection.
- Clin Ther. 1998 Nov-Dec;20(6):1071-92. Unique Identifier : AIDSLINE MED/99113641
- Pollard RB; Robinson P; Dransfield K; University of Texas Medical Branch, Galveston 77555-0835, USA.
- Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of human immunodeficiency virus disease. To establish its safety profile, we conducted a review of data from prospective US and international clinical trials involving a tot
- Transverse 1H cross relaxation in 1H-15N correlated 1H CPMG experiments.
- J Magn Reson. 1999 Mar;137(1):289-92. Unique Identifier : AIDSLINE MED/99164243
- Ishima R; Louis JM; Torchia DA; Molecular Structural Biology Unit, National Institute of Dental; and Craniofacial Research, Bethesda, Maryland, 20892-4326, USA.
- Transverse 1H cross relaxation was observed in Carr-Purcell-Meiboom-Gill (CPMG) experiments by recording 15N-1H correlated spectra of amides in HIV protease that was perdeuterated at nonexchangeable sites. Perdeuteration suppresses 1H-1H J coupling and improves spectral resolution and sensitivity. Measurements of cros
- Canada's drug problem: time to get serious [letter]
- CMAJ. 1999 Feb 23;160(4):477, 479. Unique Identifier : AIDSLINE MED/99181301
- Voth EA
- Credit for discoveries: citation data as a basis for history of science analysis.
- Theor Med Bioeth. 1998 Dec;19(6):609-20. Unique Identifier : AIDSLINE MED/99160945
- Lindahl BI; Elzinga A; Welljams-Dorof A; Department of Philosophy, Stockholm University, Sweden.
- Citation data have become an increasingly significant source of information for historians, sociologists, and other researchers studying the evolution of science. In the past few decades elaborate methodologies have been developed for the use of citation data in the study of the modern history of science. This article
- Human milk glycoconjugates that inhibit pathogens.
- Unique Identifier : AIDSLINE MED/99128419
- Newburg DS
- Breast-fed infants have lower incidence of diarrhea, respiratory disease, and otitis media. The protection by human milk has long been attributed to the presence of secretory IgA. However, human milk contains large numbers and amounts of complex carbohydrates, including glycoproteins, glycolipids, glycosaminoglycans,
- Immunomodulatory effects of tretinoin in combination with clindamycin.
- J Eur Acad Dermatol Venereol. 1998 Sep;11 Suppl 1:S2-7; discussion S28-9. Unique Identifier : AIDSLINE MED/99109051
- Wauben-Penris PJ; Cerneus DP; van den Hoven WE; Leuven PJ; den Brok JH; Hall DW; Yamanouchi Europe B.V. Research Laboratories, Leiderdorp, The; Netherlands. wauben.nl@yamanouchi-eu.com
- BACKGROUND: Since acne is a multifactorial skin disease, therapies affecting several etiologic factors can have a higher than expected effectiveness. A combination of the antibiotic clindamycin phosphate and the retinoic acid tretinoin was developed. OBJECTIVE: Anti-inflammatory and immunomodulatory effects of tretino
- Health care utilization and survival among patients with AIDS in Belo Horizonte, Minas Gerais, Brazil.
- Cad Saude Publica. 1998 Oct-Dec;14(4):811-20. Unique Identifier : AIDSLINE MED/99147188
- Acurcio F de A; Cesar CC; Guimaraes MD; Departamento de Farmacia Social e Curso de Doutorado em Ciencia; Animal, Universidade Federal de Minas Gerais, Av. Olegario; Maciel 2360, Belo Horizonte, MG 30180-112, Brasil.
- A historical cohort study was conducted in three public AIDS referral services in Belo Horizonte, Minas Gerais, to assess the relationship between health care utilization and patient survival following AIDS diagnosis. A review of medical and laboratory records was performed for HIV-infected patients seeking care for t
- Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.
- Nucleosides Nucleotides. 1999 Feb;18(2):217-25. Unique Identifier : AIDSLINE MED/99166246
- Ghosh A; Miller MJ; De Clercq E; Balzarini J; Department of Chemistry and Biochemistry, University of Notre; Dame, IN 46556, USA.
- Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate 22 is reported. Coupling of previously prepared L-alanyl-4 -azanoraristeromycin 19 with protected tripeptide trihydroxamate 20, followed by hydrogenolytic removal of all protecting groups, provided the first carbocylic azano
- Synthesis of a new class of HIV-1 inhibitors.
- Nucleosides Nucleotides. 1999 Feb;18(2):263-75. Unique Identifier : AIDSLINE MED/99166248
- Farese-Di Giorgio A; Pairot S; Patino N; Condom R; Di Giorgio C; Aumelas A; Aubertin AM; Guedj R; Laboratoire de Chimie Bio-Organique, CNRS ESA 6001, Universite; de Nice Sophia-Antipolis, France.
- A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without
- Antibody-dependent cell-mediated cytotoxicity can protect PBMC from infection by cell-associated HIV-1.
- 1999 Feb;90(2):203-12. Unique Identifier : AIDSLINE MED/99180792
- Hildreth JEK; Hampton R; Halsey NA; Department of Pharmacology and Molecular Sciences, The Johns; Hopkins University School of Medicine, Baltimore, Maryland 21205,; USA.
- We have developed a novel in vitro assay system to study the role of antibody-dependent cell-mediated cytotoxicity (ADCC) in protection against HIV-1 infection by cell-associated virus. HIV-1-infected NK-resistant cells are mixed with specific antibody and unstimulated PBMC and ADCC is allowed to occur over several ho
- Role of cytomegalovirus in the T cell changes seen in elderly individuals.
- 1999 Feb;90(2):213-9. Unique Identifier : AIDSLINE MED/99180793
- Looney RJ; Falsey A; Campbell D; Torres A; Kolassa J; Brower C; McCann R; Menegus M; McCormick K; Frampton M; Hall W; Abraham GN; Department of Medicine, University of Rochester, Rochester, New; York 14642, USA.
- The effect of prior cytomegalovirus ( CMV ) infection on the immune system was evaluated in young and elderly volunteers. Prevalence of IgG antibodies to CMV was higher in the elderly volunteers. In both age groups, there was a
- Evaluation of lymphocytic responses after treatment with Bacillus Calmette-Guerin and interferon-alpha 2b for superficial bladder cancer.
- 1999 Feb;90(2):230-7. Unique Identifier : AIDSLINE MED/99180795
- Gan YH; Mahendran R; James K; Lawrencia C; Esuvaranathan K; Department of Surgery, National University of Singapore,; Singapore.
- Bladder wash-derived lymphocytes from superficial bladder cancer patients involved in high dose BCG, low dose BCG, and low dose BCG with IFN-alpha treatments were examined. We found an increasing trend in the percentage of CD3 T cells with each weekly intravesical instillation and the proportion of CD3 T cells express
- The prognostic significance in HIV infection of immune activation represented by cell surface antigen and plasma activation marker changes.
- 1999 Feb;90(2):238-46. Unique Identifier : AIDSLINE MED/99180796
- Plaeger S; Bass HZ; Nishanian P; Thomas J; Aziz N; Detels R; King J; Cumberland W; Kemeny M; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease; (CIRID) and the Jonsson Comprehensive Cancer Center, UCLA School; of Medicine, Los Angeles, California, 90095, USA.
- One hundred and eighteen HIV-infected homosexual men without AIDS and 40 control seronegative homosexual men were assessed for 23 parameters reflecting immune activation to determine prognostic significance for occurrence of AIDS. Samples cryopreserved in 1987-1989 were analyzed, with AIDS occurrence determined by mid
- C1q autoantibodies in HIV infection: correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins.
- 1999 Feb;90(2):247-55. Unique Identifier : AIDSLINE MED/99180797
- Prohaszka Z; Daha MR; Susal C; Daniel V; Szlavik J; Banhegyi D; Nagy K; Varkonyi V; Horvath A; Ujhelyi E; Toth FD; Uray K; Hudecz F; Fust G; Third Department of Medicine, Semmelweis Medical University,; Budapest, Hungary.
- Antibodies to solid phase C1q (C1qAb) were determined in 295 serum samples from 132 HIV-infected subjects and in sera from 140 HIV-seronegative healthy individuals as control. An ELISA method applied for the determination of C1qAb in other diseases was used. In part of these sera, other autoantibodies (antibodies reac
- Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Childhood Diabetes in Finland Study Group.
- 1999 Feb;90(2):276-81. Unique Identifier : AIDSLINE MED/99180800
- Petersen JS; Kulmala P; Clausen JT; Knip M; Dyrberg T; Novo-Nordisk A/S, Bagsvaerd, DK-2880, Denmark. jspe@NOVO.DK
- To investigate whether type 1 diabetes in man is associated with a preferential Th1/Th2 response, and whether autoantibodies to one of the main autoantigens would reflect such a response, we characterized the immunoglobulin isotype profile to the 65-kDa isoform of glutamic acid decarboxylase (GAD65) in siblings to IDD
- Cardiac and autonomic evaluation in a pediatric population with human immunodeficiency virus.
- Clin Cardiol. 1999 Jan;22(1):33-6. Unique Identifier : AIDSLINE MED/99128614
- Plein D; Van Camp G; Cosyns B; Alimenti A; Levy J; Vandenbossche JL; Saint Pierre University Hospital, Cardiology Department,; Brussels, Belgium.
- BACKGROUND: Cardiac involvement in children with human immunodeficiency virus (HIV) infection is a well-known entity and occurs clinically more often in patients with advanced acquired immunodeficiency syndrome (AIDS). Autonomic dysfunction is less known, especially in children. HYPOTHESIS: The aim of this study was t
- Molecular epidemiology and antifungal susceptibility of Cryptococcus neoformans isolates from Ugandan AIDS patients.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):191-9. Unique Identifier : AIDSLINE MED/99100573
- Pfaller M; Zhang J; Messer S; Tumberland M; Mbidde E; Jessup C; Ghannoum M; Department of Pathology, University of Iowa College of Medicine,; Iowa City 52242, USA.
- Little is known of the antifungal susceptibility patterns and molecular epidemiology of Cryptococcus neoformans from tropical regions. We studied 164 clinical isolates of C. neofomans from 120 Ugandan AIDS patients with cryptococcal meningitis by analyzing their electrophoretic karyotypes and antifungal susceptibility
- Azole resistance among oral Candida species isolates from AIDS patients under ketoconazole exposure.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):211-6. Unique Identifier : AIDSLINE MED/99100576
- Milan EP; Burattini MN; Kallas EG; Fischmann O; Costa PR; Colombo AL; Division of Infectious Diseases, Escola Paulista de Medicina,; Universidade Federal de Sao Paulo, Brazil.
- This is a prospective study designed to investigate species distribution and azole susceptibility profile among Candida spp. isolated from the oral cavities of AIDS patients. One hundred thirty-two AIDS patients sequentially admitted at a teaching tertiary care hospital were enrolled in this study. Samples were obtain
- Kluyvera cryocrescens finger infection: case report and review of eighteen Kluyvera infections in human beings.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):237-41. Unique Identifier : AIDSLINE MED/99100580
- West BC; Vijayan H; Shekar R; Department of Medicine, Meridia Huron Hospital, Cleveland, Ohio; 44112, USA.
- We report a case of soft tissue infection with Kluyvera cryocrescens and a critical review of Kluyvera infections. A 31-year-old diabetic man used a new chemical for stripping the floor with his bare hands. Two days later he developed a blister on a finger which progressed to tenosynovitis in spite of intravenous nafc
- Assignment of the human endogenous retrovirus S71 (SSAV1) to chromosome 18 band q12.3 by radiation hybrid mapping.
- Cytogenet Cell Genet. 1998;83(3-4):207. Unique Identifier : AIDSLINE MED/99172088
- Kim HS; Crow TJ; Department of Psychiatry, Warneford Hospital, University of; Oxford, Oxford, UK.
- Neither dapsone hydroxylation nor cortisol 6beta-hydroxylation detects the inhibition of CYP3A4 by HIV-1 protease inhibitors.
- Eur J Clin Pharmacol. 1998 Nov-Dec;54(9-10):741-7. Unique Identifier : AIDSLINE MED/99120453
- Gass RJ; Gal J; Fogle PW; Detmar-Hanna D; Gerber JG; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA.
- OBJECTIVE: This study examined the use of dapsone N-hydroxylation and cortisol 6beta-hydroxylation, well accepted in vivo probes of cytochrome P4503A4 (CYP3A4) activity, on defining the effect of three HIV protease inhibitors on CYP3A4 activity. METHODS: Subjects fr
- Inhibition of nucleoside diphosphate kinase in rat liver mitochondria by added 3'-azido-3'-deoxythymidine.
- FEBS Lett. 1999 Feb 12;444(2-3):291-5. Unique Identifier : AIDSLINE MED/99158064
- Valenti D; Barile M; Quagliariello E; Passarella S; Dipartimento di Biochimica e Biologia Molecolare, Universita di; Bari, and Centro di Studi sui Mitocondri e Metabolismo; Energetico, C.N.R., Italy. d.valenti@biologia.uniba.it
- The effect of 3 -azido-3 -deoxythymidine on nucleoside diphosphate kinase of isolated rat liver mitochondria has been studied. This is done by monitoring the increase in the rate of oxygen uptake by nucleoside diphosphate (TDP, UDP, CDP or GDP) addition to mitochondria in state 4. It is shown that 3 -azido-3 -deoxythy
- Enhancement by vasoactive intestinal peptide of gamma-interferon production by antigen-stimulated type 1 helper T cells.
- Unique Identifier : AIDSLINE MED/99138717
- Jabrane-Ferrat N; Bloom D; Wu A; Li L; Lo D; Sreedharan SP; Turck CW; Goetzl AE; Departments of Medicine and Microbiology-Immunology, University; of California Medical Center, San Francisco, California; 94143-0711, USA.
- Vasoactive intestinal peptide (VIP) is a neuroendocrine mediator in immune tissues that affects many T cell functions through two homologous high-affinity G-protein-coupled receptors, termed VIPR1 and VIPR2. Antigen-stimulated secretion of gamma-interferon (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA
- Antioxidant defenses influence HIV-1 replication and associated cytopathic effects.
- Free Radic Biol Med. 1998 Jun;24(9):1485-91. Unique Identifier : AIDSLINE MED/98302969
- Sandstrom PA; Murray J; Folks TM; Diamond AM; HIV/Retrovirus Disease Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Disease,; Centers for Disease Control and Prevention, Atlanta, GA, USA.
- HIV-infected cells often exhibit reduced levels of antioxidant enzymes and thiols. To investigate the role of cellular antioxidant defenses in the progression of an acutely spreading HIV-1 infection, human Sup-T1 T cells were engineered to overexpress the selenium-dependent glutathione peroxidase, GSHPx-1. This enzyme
- Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
- Free Radic Biol Med. 1999 Feb;26(3-4):309-17. Unique Identifier : AIDSLINE MED/99110512
- Szabados E; Fischer GM; Toth K; Csete B; Nemeti B; Trombitas K; Habon T; Endrei D; Sumegi B; Department of Biochemistry, University Medical School Pecs,; Hungary.
- The short term cardiac side-effects of AZT (3 -azido-3 -deoxythymidine, zidovudine) was studied in rats to understand the biochemical events contributing to the development of AZT-induced cardiomyopathy. Developing rats were treated with AZT (50 mg/kg
- The complexity of pregnancy anemia in Dar-es-Salaam.
- Gynecol Obstet Invest. 1999;47(2):76-82. Unique Identifier : AIDSLINE MED/99135965
- Massawe SN; Urassa EN; Mmari M; Ronquist G; Lindmark G; Nystrom L; Department of Obstetrics and Gynaecology, Muhimbili Medical; Centre, Dar-es-Salaam, Tanzania.
- OBJECTIVES: To investigate the main causes of anemia in pregnancy in Dar-es-Salaam and identify appropriate investigations at all levels of care. MATERIALS: All pregnant women booking for antenatal care at 2 clinics (n = 2,235) were screened for anemia. Investigations for etiology of anemia were done in all anemic wom
- Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model.
- Hepatology. 1999 Mar;29(3):746-55. Unique Identifier : AIDSLINE MED/99162365
- Trop S; Samsonov D; Gotsman I; Alper R; Diment J; Ilan Y; Liver Unit, Division of Medicine, Hadassah University Hospital,; Jerusalem, Israel.
- Oral tolerance is the induction of immunological hyporesponsiveness towards orally administered antigens. Tolerance initiation involves induction of anti-inflammatory (Th2) lymphocytes, with downregulation of pro-inflammatory (Th1) lymphocytes. The liver was previously shown to play a critical role in oral tolerance i
- Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B.Lamivudine Precore Mutant Study Group.
- Hepatology. 1999 Mar;29(3):889-96. Unique Identifier : AIDSLINE MED/99162383
- Tassopoulos NC; Volpes R; Pastore G; Heathcote J; Buti M; Goldin RD; Hawley S; Barber J; Condreay L; Gray DF; Western Attica General Hospital, Athens, Greece.
- This placebo controlled, double-blind study evaluated the efficacy and safety of lamivudine in patients with hepatitis B e antigen (HBeAg)-negative/hepatitis B virus (HBV) DNA-positive chronic hepatitis B. Patients were randomized to receive 100 mg lamivudine orally once daily for 52 weeks (n = 60) or placebo for 26 w
- Viral load and clinicopathological features of chronic hepatitis C (1b) in a homogeneous patient population.
- Hepatology. 1999 Mar;29(3):904-7. Unique Identifier : AIDSLINE MED/99162385
- Fanning L; Kenny E; Sheehan M; Cannon B; Whelton M; O'Connell J; Collins JK; Shanahan F; Department of Medicine, National University of Ireland, Cork,; University College Cork, Ireland. L.FANNING@UCCE.IE
- Monitoring the progression of hepatitis C virus (HCV) includes clinical, biochemical, and histological parameters. Quantitation of viral load by reverse-transcription polymerase chain reaction (RT-PCR) may offer a more reliable marker of disease status. Conflicting reports on viral titers may reflect heterogeneity of
- YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection.
- Hepatology. 1999 Mar;29(3):939-45. Unique Identifier : AIDSLINE MED/99162390
- Ono-Nita SK; Kato N; Shiratori Y; Masaki T; Lan KH; Carrilho FJ; Omata M; Second Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Tokyo, Japan.
- Recently, lamivudine used to treat patients with hepatitis B virus (HBV) infection was revealed to have potent antiviral activity. However, HBV resistance to lamivudine has been reported and shown to have amino acid substitutions in the methionine residue of the conserved tyrosine (Y), methionine (M), aspartate (D), a
- Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver.
- Hepatology. 1999 Mar;29(3):985-7. Unique Identifier : AIDSLINE MED/99162396
- de la Asuncion JG; del Olmo ML; Sastre J; Pallardo FV; Vina J; Departamento de Fisiologia, Facultad de Medicina, Universidad de; Valencia, Valencia, Spain.
- Zidovudine (3 -azido-2 ,3 -dideoxythymidine [ AZT ]) inhibits human immunodeficiency virus replication and delays progression of acquired immune deficiency syndrome. We have recently found that, in muscle, AZT causes oxidative damage to mitochondrial DN
- Mother-infant hepatitis C transmission: second generation research.
- Hepatology. 1999 Mar;29(3):992-3. Unique Identifier : AIDSLINE MED/99162399
- Thomas DL; Johns Hopkins Medical Institutions, Baltimore, MD, USA.
- Human T-cell leukemia virus type 1 can infect a wide variety of cells in mice.
- Jpn J Cancer Res. 1999 Jan;90(1):48-54. Unique Identifier : AIDSLINE MED/99175860
- Feng R; Tanaka M; Abe H; Arashi N; Sun B; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Ibaraki.
- Analysis of human T-cell leukemia virus type 1 (HTLV-1)-infected cell types and the interplay of these infected cells in vivo should provide valuable information to elucidate the pathogenesis of HTLV-1-associated diseases in humans and in animal models. In this study, HTLV-1-infected cell types were identified in HTLV
- Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase.
- J Biol Chem. 1999 Mar 5;274(10):6660-6. Unique Identifier : AIDSLINE MED/99156953
- Louis JM; Oroszlan S; Tozser J; Laboratory of Chemical Physics, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892, USA. jmlouis@helix.nih.gov
- We have developed a system for expression and purification of wild-type human T-cell leukemia virus type 1 (HTLV-1) proteinase to attain sufficient quantities for structural, kinetic, and biophysical investigations. However, similar to the human immunodeficiency virus type 1 (HIV-1) proteinase, HTLV-1 proteinase also
- Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells.
- J Biol Chem. 1999 Mar 5;274(10):6698-703. Unique Identifier : AIDSLINE MED/99156957
- Coccia EM; Passini N; Battistini A; Pini C; Sinigaglia F; Rogge L; Laboratory of Immunology, Istituto Superiore di Sanita, I-00161; Rome, Italy.
- IRF-1-deficient mice show a striking defect in the development of T helper 1 (Th1) cells. In the present report, we investigate the expression of IRF-1 during differentiation of human T helper cells. No significant differences of IRF-1 mRNA expression were found in established Th1 and Th2 cells; however, interleukin 1
- Depression predicts procedural but not episodic memory in HIV-1 infection.
- J Clin Exp Neuropsychol. 1998 Aug;20(4):529-35. Unique Identifier : AIDSLINE MED/99107074
- Kalechstein AD; Hinkin CH; van Gorp WG; Castellon SA; Satz P; Department of Psychiatry and Biobehavioral Sciences, University; of California Los Angeles Neuropsychiatric Institute and; Hospital, USA. adk@ucla.edu
- Forty-three homosexual/bisexual males with HIV-1 infection participated in a study that sought to determine: (1) whether increased levels of self-reported depressive symptomatology were associated with poorer performance on episodic or procedural memory tasks, (2) the relative strength of association between the affec
- Syphilis in an HIV infected patient misdiagnosed as leprosy.
- J Cutan Pathol. 1999 Jan;26(1):51-4. Unique Identifier : AIDSLINE MED/99140241
- Fonseca E; Garcia-Silva J; del Pozo J; Yebra MT; Cuevas J; Contreras F; Department of Dermatology, Hospital Juan Canalejo, La Coruna,; Spain. Fonseca@canalejo.cesga.es
- A 42-year-old man with uveitis and a widespread cutaneous eruption, histopathologically characterized by dermal granulomatous infiltrates with perineurial invasion, was incorrectly diagnosed and treated as having borderline leprosy. Further studies demonstrated secondary syphilis and human immunodeficiency virus (HIV)
- Epidemiology of HIV and AIDS in Bahrain.
- J Commun Dis. 1997 Dec;29(4):321-8. Unique Identifier : AIDSLINE MED/99185556
- al-Haddad MK; Baig BZ; Ebrahim RA; Psychiatric Hospital, Bahrain, Arabian Gulf.
- Between 1986 and 1996, 378 HIV cases were identified in Bahrain , of whom 51% were foreign nationals. Intravenous drug abuse was a major risk factor (38.8%) among Bahraini nationals, while transmission through sexual contact was more common (45.7%) among foreigners. Other well know
- The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.
- J Infect Dis. 1999 Mar;179(3):527-37. Unique Identifier : AIDSLINE MED/99137787
- Markowitz M; Vesanen M; Tenner-Racz K; Cao Y; Binley JM; Talal A; Hurley A; Ji X; Chaudhry MR; Yaman M; Frankel S; Heath-Chiozzi M; Leonard JM; Moore JP; Racz P; Nixon DF; Ho DD; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, NY 10016, USA. marty@adarc.org
- Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset of symptoms of acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) infection could be eradicated from an infected host. In adh
- Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons.
- J Infect Dis. 1999 Mar;179(3):538-47. Unique Identifier : AIDSLINE MED/99137788
- Bernard NF; Yannakis CM; Lee JS; Tsoukas CM; Immunodeficiency Treatment Center, McGill University Hospital; Center, Montreal General Hospital, Montreal, Quebec, H3G 1A4,; Canada. mctl@musica.mcgill.ca
- Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus-spec
- Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects.
- J Infect Dis. 1999 Mar;179(3):548-57. Unique Identifier : AIDSLINE MED/99137789
- Goh WC; Markee J; Akridge RE; Meldorf M; Musey L; Karchmer T; Krone M; Collier A; Corey L; Emerman M; McElrath MJ; Division of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-1024, USA. wgoh@fhcrc.org
- It has been hypothesized that protection against human immunodeficiency virus (HIV)-1 infection may result from either acquired host immunity, inheritance of a dysfunctional CCR5 HIV-1 coreceptor, or a low or attenuated virus inoculum. Thirty-seven HIV-1-uninfected persons engaging in repeated high-risk sexual activit
- Immunization with human immunodeficiency virus type 1 rgp120W61D in QS21/MPL adjuvant primes T cell proliferation and C-C chemokine production to multiple epitopes within variable and conserved domains of gp120W61D.
- J Infect Dis. 1999 Mar;179(3):558-66. Unique Identifier : AIDSLINE MED/99137790
- Jones GJ; von Hoegen P; Weber J; Rees AD; GU Medicine and Communicable Diseases, Imperial College School of; Medicine at St. Mary's, London, W2 1PG, United Kingdom.; gareth.jones@ic.ac.uk
- Human immunodeficiency virus type 1 (HIV-1) gp120W61D-specific T cell lines (TCL) were generated from an HIV-1-seronegative volunteer who received rgp120W61D in QS21/MPL adjuvant with emulsion. TCL were challenged with pools of consecutive, overlapping peptides spanning the gp120W61D sequence and then with the individ
- Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group protocol 185.
- J Infect Dis. 1999 Mar;179(3):567-75. Unique Identifier : AIDSLINE MED/99137791
- Stiehm ER; Lambert JS; Mofenson LM; Bethel J; Whitehouse J; Nugent R; Moye J Jr; Glenn Fowler M; Mathieson BJ; Reichelderfer P; Nemo GJ; Korelitz J; Meyer WA 3rd; Sapan CV; Jimenez E; Gandia J; Scott G; O'Sullivan MJ; Kovacs A; Stek A; Shearer WT; Hammill H; Department of Pediatrics, University of California at Los Angeles; Medical Center, Los Angeles, CA 90095-1752, USA.; estiehm@pediatrics.medsch.ucla.edu
- Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared with treatment wit
- Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children.
- J Infect Dis. 1999 Mar;179(3):576-83. Unique Identifier : AIDSLINE MED/99137792
- Palumbo PE; Raskino C; Fiscus S; Pahwa S; Schutzbank T; Spector SA; Baker CJ; Englund JA; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey, Newark, NJ 07103, USA. palumbo@umdnj.edu
- Plasma human immunodeficiency virus RNA and CD4 lymphocyte response to nucleoside reverse-transcriptase therapy were evaluated in a large, comparative pediatric trial. Both baseline values and changes in the two laboratory markers over time correlated well with clinical outcome and possessed independent predictive val
- Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children.
- J Infect Dis. 1999 Mar;179(3):584-9. Unique Identifier : AIDSLINE MED/99137793
- Hayani KC; Verral SC; Pitrak DL; Division of Pediatric Infectious Diseases, Department of; Pediatrics, University of Illinois College of Medicine at; Chicago, Chicago, IL 60612-7324, USA. U12017@UIC.edu
- Children infected with the human immunodeficiency virus (HIV) have T helper cell deficiency, but frequent bacterial infections suggest phagocyte dysfunction. Whole blood chemiluminescence (CL) assays were used to measure the respiratory burst capacity of phagocytes from HIV-infected children, perinatally HIV-exposed b
- Maternal virus load and perinatal human immunodeficiency virus type 1 subtype E transmission, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group.
- J Infect Dis. 1999 Mar;179(3):590-9. Unique Identifier : AIDSLINE MED/99137794
- Shaffer N; Roongpisuthipong A; Siriwasin W; Chotpitayasunondh T; Chearskul S; Young NL; Parekh B; Mock PA; Bhadrakom C; Chinayon P; Kalish ML; Phillips SK; Granade TC; Subbarao S; Weniger BG; Mastro TD; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA. nas4@cdc.gov
- To determine the rate and risk factors for human immunodeficiency virus (HIV)-1 subtype E perinatal transmission, with focus on virus load, pregnant HIV-infected women and their formula-fed infants were followed prospectively in Bangkok. Of 281 infants with known outcome, 68 were infected (transmission rate, 24.2%; 95
- Coinfection of macaques with simian immunodeficiency virus and simian T cell leukemia virus type I: effects on virus burdens and disease progression.
- Unique Identifier : AIDSLINE MED/99137795
- Fultz PN; McGinn T; Davis IC; Romano JW; Li Y; Department of Microbiology, University of Alabama School of; Medicine, Birmingham, AL 35294, USA.
- To test the hypothesis that coinfection with human immunodeficiency virus (HIV) and human T cell leukemia/lymphoma virus types I or II (HTLV-I or -II) accelerates progression to AIDS, pig-tailed macaques were inoculated with the simian counterparts, SIV and STLV-I. During 2 years of follow-up of singly and dually infe
- Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB.
- J Infect Dis. 1999 Mar;179(3):653-60. Unique Identifier : AIDSLINE MED/99137801
- Klebanoff SJ; Watts DH; Mehlin C; Headley CM; Department of Medicine, University of Washington, Seattle, WA; 98195-7185, USA. seym@u.washington.edu
- Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines. Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2. In con
- Infrequent detection of TT virus infection in intravenous drug users, prostitutes, and homosexual men.
- J Infect Dis. 1999 Mar;179(3):686-9. Unique Identifier : AIDSLINE MED/99137806
- MacDonald DM; Scott GR; Clutterbuck D; Simmonds P; Department of Medical Microbiology, University of Edinburgh,; Edinburgh, EH8 9AG, United Kingdom.
- TT virus (TTV), a recently discovered DNA virus, has been implicated as a cause of non-A to non-C posttransfusion hepatitis. The frequency of TTV in persons considered at high risk for sexual and parenteral infection was investigated (52 prostitutes, 81 homosexual men, 65 intravenous drug users) to assess its mode of
- Expression of granzyme B during primary cytomegalovirus infection after renal transplantation.
- J Infect Dis. 1999 Mar;179(3):693-6. Unique Identifier : AIDSLINE MED/99137808
- Wever PC; Spaeny LH; van der Vliet HJ; Rentenaar RJ; Wolbink AM; Surachno J; Wertheim PM; Schellekens PT; Hack CE; ten Berge IJ; Department of Medical Microbiology, Academic Medical Center,; University of Amsterdam, Amsterdam, The Netherlands.
- CD8+ T cells employ granzyme B (GrB) to induce apoptosis in target cells. Increased expression of GrB has been put forward as a diagnostic marker in transplant rejection and viral infection. Three-color flow cytometric analysis revealed that peripheral blood CD8+ T lymphocytosis during primary
- Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy.
- J Infect Dis. 1999 Mar;179(3):697-700. Unique Identifier : AIDSLINE MED/99137809
- Karavellas MP; Plummer DJ; Macdonald JC; Torriani FJ; Shufelt CL; Azen SP; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California, San Diego, La Jolla, CA 92093-0946, USA.; mkaravellas@netscape.net
- This study was conducted to determine the likelihood of the development of a new ocular inflammatory syndrome (immune recovery vitritis, IRV), which causes vision loss in AIDS patients with cytomegalovirus ( CMV ) retinitis, wh
- Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population.
- J Infect Dis. 1999 Mar;179(3):701-4. Unique Identifier : AIDSLINE MED/99137810
- Konya J; Thompson CH; Department of Infectious Diseases, Faculty of Medicine,; University of Sydney, Sydney, New South Wales 2006, Australia.
- An ELISA for molluscum contagiosum virus (MCV) was used to determine the antibody status of 35 adults with clinical infections and known human immunodeficiency virus (HIV) serology and of 357 persons (ages, 1 week-69 years) considered representative of the Australian population. MCV antibody was identified in 77% of p
- Codon 215 mutations in human immunodeficiency virus-infected pregnant women. Swiss Collaborative 'HIV and Pregnancy' Study.
- J Infect Dis. 1999 Mar;179(3):705-8. Unique Identifier : AIDSLINE MED/99137811
- Kully C; Yerly S; Erb P; Kind C; Krautheim A; Perrin L; Rudin C; Department of Pediatrics, University Children's Hospital, CH-4058; Basel, Switzerland. charlotte.kully@pupk.unibe.ch
- In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 demonstrated a two-thirds reduction of perinatal human immunodeficiency virus (HIV) type 1 transmission with zidovudine chemoprophylaxis. However, zidovudine alone does not fully suppress HIV replication, and chemoprophylaxis with zidovudine alone
- Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group.
- J Infect Dis. 1999 Mar;179(3):709-13. Unique Identifier : AIDSLINE MED/99137812
- Kleim JP; Winters M; Dunkler A; Suarez JR; Riess G; Winkler I; Balzarini J; Oette D; Merigan TC; Clinical Virology Unit, Glaxo Wellcome, Stevenage, Herts SG1 2NY,; United Kingdom. jpk49970@GlaxoWellcome.co.uk
- The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation study. Mean maximum virus load decreases ranged from -1.31 log10 copi
- LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii.
- J Infect Dis. 1999 Mar;179(3):714-6. Unique Identifier : AIDSLINE MED/99137813
- Mayatepek E; Flock B; Zelezny R; Kreutzer K; von Giesen HJ; Department of General Pediatrics, University Children's Hospital,; 69120 Heidelberg, Germany. ertan_mayatepek@ukl.uni-heidelberg.de
- Previous studies on macrophages have shown that Toxoplasma gondii alters the metabolism of arachidonic acid with subsequent inability to generate leukotrienes (LT)s. LTB4 and LTC4 were analyzed in cerebrospinal fluid of 3 groups of human immunodeficiency virus (HIV) type 1-seropositive patients: with toxoplasmic encep
- Combination antiretroviral therapy and recent declines in AIDS incidence and mortality.
- J Infect Dis. 1999 Mar;179(3):717-20. Unique Identifier : AIDSLINE MED/99137814
- Vittinghoff E; Scheer S; O'Malley P; Colfax G; Holmberg SD; Buchbinder SP; Department of Epidemiology and Biostatistics, University of; California, San Francisco, CA 94105, USA. eric@retriever.ucsf.edu
- The reasons for recent declines in AIDS incidence and mortality may include advances in treatment, but these may be confounded by earlier declines in the incidence of human immunodeficiency virus (HIV) infection. To determine whether the declines in AIDS and mortality may, in part, stem from wider use of combination a
- Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5).
- J Leukoc Biol. 1999 Mar;65(3):281-5. Unique Identifier : AIDSLINE MED/99178613
- Olbrich H; Proudfoot AE; Oppermann M; Department of Immunology, University of Gottingen, Germany.
- The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and amino-terminal modificat
- Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma.
- J Clin Oncol. 1999 Feb;17(2):554-60. Unique Identifier : AIDSLINE MED/99178684
- Antinori A; De Rossi G; Ammassari A; Cingolani A; Murri R; Di Giuda D; De Luca A; Pierconti F; Tartaglione T; Scerrati M; Larocca LM; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy. andranto@tin.it
- PURPOSE: To determine the diagnostic capability of thallium-201 (201Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL). PATIENTS AND METHODS: All human immunodef
- Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome.
- J Neurooncol. 1998 Nov;40(2):179-83. Unique Identifier : AIDSLINE MED/99107118
- Litofsky NS; Pihan G; Corvi F; Smith TW; Division of Neurosurgery, University of Massachusetts Medical; School, Worcester 01655, USA. scott.litofsky@banyan.ummed.edu
- Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness.
- Individual, family, and relationship predictors of young women's sexual risk perceptions.
- Unique Identifier : AIDSLINE MED/99122253
- Hutchinson MK
- OBJECTIVE: To identify the individual, dyad, and family variables that influence young women s perceptions of risk for sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV). DESIGN: Cross-sectional telephone survey using forced-choice questioning. Data were analyzed using first-order corre
- Analysis of peripheral blood leukocytes in patients with cyclosporine A-induced gingival hyperplasia.
- J Periodontol. 1998 Dec;69(12):1435-9. Unique Identifier : AIDSLINE MED/99123965
- Cebeci I; Kantarci A; Gurel N; Adin S; Tuncer O; Carin M; Badur S; Firatli E; Department of Periodontology, School of Dentistry, University of; Istanbul, Turkey.
- BACKGROUND: Gingival overgrowth is one of the major adverse effects of the immunosuppressive drug cyclosporine A (CsA). Although several studies have attempted to determine the immunological mechanisms of gingival hyperplasia (GO) due to CsA therapy, the pathogenesis remains unclear. In this study, the distribution of
- Thematic instrument for measuring death anxiety in children (TIMDAC).
- J Pediatr Nurs. 1999 Feb;14(1):28-37. Unique Identifier : AIDSLINE MED/99162733
- Ireland M; Malgady RG; College of Nursing, Rutgers, State University of New Jersey,; Newark 07102, USA.
- Few instruments measure death anxiety in children, especially, children of color. This article describes the development and psychometric properties of the projective instrument, the Thematic Instrument for Measuring Death Anxiety in Children (TIMDAC), a culturally sensitive tool that was developed to compare levels o
- Development of a single-shot subunit vaccine for HIV-1. 5. programmable in vivo autoboost and long lasting neutralizing response.
- J Pharm Sci. 1998 Dec;87(12):1489-95. Unique Identifier : AIDSLINE MED/99140449
- Cleland JL; Lim A; Daugherty A; Barron L; Desjardin N; Duenas ET; Eastman DJ; Vennari JC; Wrin T; Berman P; Murthy KK; Powell MF; Department of Pharmaceutical Research and Development, Genentech,; Inc., South San Francisco, California 94080, USA.; cleland@gene.com
- The subunit vaccine for HIV-1, recombinant glycoprotein 120 (rgp120), was used as a model antigen to evaluate the potential for a pulsatile single immunization vaccine formulation consisting of poly(lactic-co-glycolic) acid (PLGA) microspheres. We designed rgp120 PLGA microsphere formulations that provide a pulse of r
- N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents.
- J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84. Unique Identifier : AIDSLINE MED/99152177
- Sarnstrand B; Jansson AH; Matuseviciene G; Scheynius A; Pierrou S; Bergstrand H; Department of Pharmacology, Astra Draco AB, Lund, Sweden.
- Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N -diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents. Oral treatment
- Nuclear medicine imaging in infection and inflammation.
- J R Coll Physicians Lond. 1998 Nov-Dec;32(6):512-9. Unique Identifier : AIDSLINE MED/99097979
- Peters AM; Department of Imaging, Hammersmith Hospital, London.
- Tuberculosis in African born adults [letter]
- J R Coll Physicians Lond. 1998 Nov-Dec;32(6):589-90. Unique Identifier : AIDSLINE MED/99097995
- Coker R
- Recombination during reverse transcription: an evaluation of the role of the nucleocapsid protein.
- J Mol Biol. 1999 Feb 12;286(1):15-31. Unique Identifier : AIDSLINE MED/99134385
- Negroni M; Buc H; Unite de Physicochimie des Macromolecules Biologiques, (URA1773; du CNRS), Paris Cedex 15, 75724, France. matteo@pasteur.fr
- The human immuno deficiency virus type 1 nucleocapsid protein 7 (HIV-1 NCp7) is a major component of the reverse transcription complex. Its effect on reverse transcription and homologous recombination has been studied in vitro under strictly identical experimental conditions. For high enzyme concentrations, NCp7 did n
- Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26.
- J Mol Biol. 1999 Feb 12;286(1):83-93. Unique Identifier : AIDSLINE PDB/2EIA
- Jin Z; Jin L; Peterson DL; Lawson CL; Biology Department, Brookhaven National Laboratory, Upton, NY,; 11973, USA.
- Two crystal forms of recombinant p26 capsid protein (CA) from the equine infectious anemia virus (EIAV) have in common an antiparallel four-helix bundle dimer interface between N-terminal domains (NTDs). The dimer interface provides a lenient scaffold to accommodate the wide sequence variation in these helices within
- Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.
- Lab Invest. 1999 Feb;79(2):243-51. Unique Identifier : AIDSLINE MED/99165581
- Weninger W; Partanen TA; Breiteneder-Geleff S; Mayer C; Kowalski H; Mildner M; Pammer J; Sturzl M; Kerjaschki D; Alitalo K; Tschachler E; Division of Immunology, Allergy, and Infectious Diseases,; University of Vienna, Austria.
- Despite intensive research over the past decade, the exact lineage relationship of Kaposi s sarcoma (KS) tumor cells has not yet been settled. In the present study, we investigated the expression of two markers for lymphatic endothelial cells (EC), ie, vascular endothelial growth factor receptor-3 (VEGFR-3) and podopl
- Meningioma in four patients with human immunodeficiency virus infection.
- Mayo Clin Proc. 1999 Mar;74(3):253-7. Unique Identifier : AIDSLINE MED/99189864
- Khurshid A; Joseph JT; Rachlin J; Cooley TP; Kleefield J; Dezube BJ; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Boston, MA 02215, USA.
- We describe four patients infected with the human immunodeficiency virus (HIV) who had development of meningiomas. In contrast to those in the general population who have meningiomas, all our patients were young men; the mean age was 40 years (range, 32 to 50). Their risk behavior for HIV was homosexuality (three pati
- [Promising experiments with DNA vaccine against HIV. A complete eradication of the virus is a formidable task]
- Lakartidningen. 1999 Feb 17;96(7):722-5. Unique Identifier : AIDSLINE MED/99187738
- Wahren B; Smittskyddsinstitutet, Karolinska institutet, Stockholm.; Britta.Wahren@smi.ki.se
- The past few years have witnessed encouraging progress in experimental HIV vaccination. Several new vaccine candidates have been shown to elicit immune response and provide protection in animals, and the first immunotherapy trials in humans have been reported. Difficulties remain to be overcome, however. No consensus
- Rifapentine--a long-acting rifamycin for tuberculosis.
- Med Lett Drugs Ther. 1999 Feb 26;41(1047):21-2. Unique Identifier : AIDSLINE MED/99175890
- Pilot study with clozapine in patients with HIV-associated psychosis and drug-induced parkinsonism.
- Mov Disord. 1999 Jan;14(1):128-31. Unique Identifier : AIDSLINE MED/99114914
- Lera G; Zirulnik J; Neurology Unit, Juan A. Fernandez Hospital, Buenos Aires,; Argentina.
- Clozapine (CZP) is an atypical antipsychotic drug that does not appear to block striatal dopamine receptors. In six patients who met the criteria of HIV-associated psychosis and who had previously developed moderate parkinsonism as a result of the use of typical neuroleptic agents, CZP was added in an open, rising dos
- Elective cesarean delivery to reduce the transmission of HIV [editorial; comment]
- N Engl J Med. 1999 Apr 1;340(13):1032-3. Unique Identifier : AIDSLINE MED/99182219
- Riley LE; Greene MF
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1040-1; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182223
- Fiscus SA; Schoenbach VJ; Wilfert C
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1041; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182224
- Thomas P; Bornschlegel K
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1041-2; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182225
- Feiterna-Sperling C; Maier RF; Grosch-Worner I
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1042-3. Unique Identifier : AIDSLINE MED/99182226
- Shaffer N; Bulterys M; Simonds RJ
- Human herpesvirus 8 and renal transplantation [letter]
- N Engl J Med. 1999 Apr 1;340(13):1045; discussion 1046. Unique Identifier : AIDSLINE MED/99182229
- Frances C; Mouquet C; Calvez V
- Human herpesvirus 8 and renal transplantation [letter]
- N Engl J Med. 1999 Apr 1;340(13):1045-6. Unique Identifier : AIDSLINE MED/99182230
- Rabkin CS; Shepherd FA; Wade JA
- The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group [see comments]
- N Engl J Med. 1999 Apr 1;340(13):977-87. Unique Identifier : AIDSLINE MED/99182213
- BACKGROUND: To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. METHODS: North American and European studies of at least 100 mother-child p
- [Vertical HIV-I-transmission. I. Risk and prevention in pregnancy]
- Ned Tijdschr Geneeskd. 1998 Dec 12;142(50):2720-4. Unique Identifier : AIDSLINE MED/99164629
- Orendi JM; Boer K; van Loon AM; Borleffs JC; van Oppen AC; Boucher CA; Eijkman-Winkler Laboratorium voor Microbiologie, Infectieziekten; en Ontsteking, afd. Virologie, Academisch Ziekenhuis Utrecht.
- Without anti-HIV treatment, mother to child HIV-I transmission occurs in 15-30% of HIV positive pregnancies. Transmission occurs mostly in the last trimester or at birth. The maternal virus load in the last trimester and around birth is strongly related to the risk of HIV transmission to the child. This risk can be re
- [Vertical HIV-I-transmission. II. HIV-diagnosis in a child]
- Ned Tijdschr Geneeskd. 1998 Dec 12;142(50):2724-8. Unique Identifier : AIDSLINE MED/99164630
- Orendi JM; Geelen SP; de Graeff-Meeder ER; van Loon AM; Schuurman R; Boucher CA; Eijkman-Winkler Laboratorium voor Microbiologie, Infectieziekten; en Ontsteking, afd. Virologie, Academisch Ziekenhuis Utrecht.
- In newborn children from HIV-infected women early establishment of HIV infection is of importance for optimal therapy of HIV-infected children and avoidance of unnecessary medication in uninfected children. A more than 95% reliable diagnosis of HIV infection can now be obtained at the age of four weeks by polymerase c
- Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):453-60. Unique Identifier : AIDSLINE MED/99105102
- Soontornniyomkij V; Wang G; Pittman CA; Wiley CA; Achim CL; Department of Pathology (Neuropathology), University of; Pittsburgh School of Medicine, Pennsylvania, USA.
- The role of neurotrophic factors and their therapeutic potential have been investigated in various neurodegenerative disorders. In neurodegeneration associated with human immunodeficiency virus (HIV) infection, neuronal function and survival may be affected by abnormal neurotrophic regulation involving HIV-infected mi
- A murine model of HIV encephalitis: xenotransplantation of HIV-infected human neuroglia into SCID mouse brain.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):461-7. Unique Identifier : AIDSLINE MED/99105103
- Sanders VJ; Mehta AP; White MG; Achim CL; Department of Pathology, University of Pittsburgh School of; Medicine, PA 15213, USA.
- The degree of neuronal damage in HIV encephalitis (HIVE) and the mechanisms leading to it are not known. Post-mortem human studies provide limited information concerning pathogenesis, and there are few animal models of HIVE. We have developed a murine model of HIVE based on HIV-infected human brain tissues grafted wit
- Changes in neuron size in cynomolgus macaques infected with various immunodeficiency viruses and poliovirus.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):468-75. Unique Identifier : AIDSLINE MED/99105104
- Montgomery MM; Wood A; Stott EJ; Sharp C; Luthert PJ; Department of Pathology, University College London, UK.
- Human immunodeficiency virus (HIV) infection leads to clinically significant neuronal pathology, but the underlying mechanism remains unclear. Infection of rhesus macaques with the simian immunodeficiency virus SIVmac251 has been shown to cause atrophy of hippocampal pyramidal cells. The aim of the current investigati
- Interleukin-6 production by human monocytes treated with granulocyte-macrophage colony-stimulating factor in the presence of lipopolysaccharide of oral microorganisms.
- Oral Microbiol Immunol. 1998 Jun;13(3):173-80. Unique Identifier : AIDSLINE MED/99193492
- Baqui AA; Meiller TF; Chon JJ; Turng BF; Falkler WA Jr; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore, USA.
- This study focused on the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) and lipopolysaccharide of the putative periodontal pathogens Porphyromonas gingivalis or Fusobacterium nucleatum on IL-6 production by THP-1 cells (a human monocytic cell line). Resting THP-1 cells were alternatively treated
- Characterization of lymphocyte subpopulations in periapical lesions by flow cytometry.
- Oral Microbiol Immunol. 1998 Aug;13(4):253-8. Unique Identifier : AIDSLINE MED/99193501
- Sol MA; Tkaczuk J; Voigt JJ; Durand M; Sixou M; Maurette A; Thomsen M; Institut National de la Sante et de la Recherche Medicale, Unit; 466, Toulouse, France.
- The mechanisms by which the bacterial root-canal infection leads to periapical bone destruction (cysts or granulomas) are not yet well understood. Previous works have shown elements of an active immune response in the lesions. In the present study, flow cytometry was used to improve the characterization of immune cell
- Distribution of interleukin-2 receptor alpha-chain and cells expressing major histocompatibility complex class II antigen in chronic human periapical lesions.
- Oral Microbiol Immunol. 1998 Aug;13(4):259-62. Unique Identifier : AIDSLINE MED/99193502
- Marton IJ; Dezso B; Radics T; Kiss C; Department of Restorative Dentistry, University Medical School of; Debrecen, Hungary.
- In situ distribution of CD2+ T-lymphocytes, CD4+ and CD8+ T-cell subsets, CD14+ macrophages, interleukin-2 receptor alpha-chain (IL-2R alpha) and class II major histocompatibility complex antigen (major histocompatibility complex class II, HLA-DR) expressing cells were determined in 14 chronic human periapical granulo
- Discriminating against people with HIV.
- Nurs Times. 1999 Feb 10-16;95(6):21. Unique Identifier : AIDSLINE MED/99195323
- Mayho P
- Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast.
- Placenta. 1999 Jan;20(1):109-18. Unique Identifier : AIDSLINE MED/99133651
- Lin L; Xu B; Rote NS; Department of Microbiology and Immunology, Wright State; University School of Medicine, Dayton, Ohio 45435, USA.
- Differentiation-related expression of endogenous retrovirus ERV-3 env in the normal human placental syncytiotrophoblast suggests a role in placental development. The choriocarcinoma cell line BeWo, a model of trophoblast differentiation, is maintained in an undifferentiated state and undergoes differentiation upon the
- Pain and depression in HIV illness.
- Psychosomatics. 1998 Nov-Dec;39(6):528-35. Unique Identifier : AIDSLINE MED/99037388
- Evans S; Ferrando S; Sewell M; Goggin K; Fishman B; Rabkin J; Department of Psychiatry, Cornell University Medical College, New; York, NY, USA. SUSAN_EVANS@yahoo.com
- The purpose of this study was to examine the relationship among pain and depression, hopelessness, and quality of life in human immunodeficiency virus (HIV)-infected gay men, taking into account the role of HIV symptoms. One hundred sixty-one HIV+ gay men were assessed, with 40 men endorsing HIV-related pain. The HIV+
- New-onset amnestic syndrome in AIDS patients with past history of alcohol abuse.
- Psychosomatics. 1998 Nov-Dec;39(6):551-3. Unique Identifier : AIDSLINE MED/99037393
- Viswanathan R; Pilman M; Hasaj M; State University of New York Health Science Center at Brooklyn; 11203, USA.
- [Check-up studies at an internal medicine polyclinic: reasons, diagnostic tests, results and therapeutic consequences]
- Unique Identifier : AIDSLINE MED/99106259
- Osterwalder P; Steurer J; Departement fur Innere Medizin, Medizinische Poliklinik,; Zurich.
- Data of an investigation on initial motives for and outcome of so-called diagnostic check-ups are presented. Over a period of about one year a total of 82 persons applying for such a check-up have been investigated. Concrete reasons for this step were not given initially, however, elucidated in 87% of cases after spec
- Linear differentiation of cytotoxic effectors into memory T lymphocytes.
- Science. 1999 Mar 12;283(5408):1745-8. Unique Identifier : AIDSLINE MED/99174090
- Opferman JT; Ober BT; Ashton-Rickardt PG; Committee on Immunology, Department of Pathology, Committee on; Developmental Biology, The University of Chicago, Gwen Knapp; Center for Lupus and Immunology Research, Chicago, IL 60637, USA.
- A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naive T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after
- HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
- Science. 1999 Mar 12;283(5408):1748-52. Unique Identifier : AIDSLINE MED/99174091
- Carrington M; Nelson GW; Martin MP; Kissner T; Vlahov D; Goedert JJ; Kaslow R; Buchbinder S; Hoots K; O'Brien SJ; Intramural Research Support Program, Science Applications; International Corporation Frederick, National Cancer Institute; (NCI), Frederick, MD 21702-1201, USA.
- A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of
- Combined effects of HIV-infection status and psychosocial vulnerability on mental health in homosexual men.
- Soc Psychiatry Psychiatr Epidemiol. 1999 Jan;34(1):4-11. Unique Identifier : AIDSLINE MED/99172770
- Dickey WC; Dew MA; Becker JT; Kingsley L; Department of Epidemiology and Psychiatry, University of; Pittsburgh, Graduate School of Public Health, School of Medicine,; Pennsylvania, USA. dickeywc@msx.upmc.edu
- The present study examines psychiatric symptomatology and syndromal depression among 174 HIV+ and 760 HIV- homosexual men enrolled in the Pittsburgh site of the Multicenter AIDS Cohort Study (MACS). A central study goal was to determine whether men s psychosocial status in the areas of demographics, social supports, a
- Abacavir for treatment of HIV infection [news]
- Am Fam Physician. 1999 Mar 1;59(5):1329. Unique Identifier : AIDSLINE MED/99186744
- Endoscopic approach to HIV-associated diarrhea: how far is far enough? [editorial; comment]
- Am J Gastroenterol. 1999 Mar;94(3):556-9. Unique Identifier : AIDSLINE MED/99184435
- Bini EJ
- A prospective study of endoscopy in HIV-associated diarrhea [see comments]
- Am J Gastroenterol. 1999 Mar;94(3):596-602. Unique Identifier : AIDSLINE MED/99184441
- Kearney DJ; Steuerwald M; Koch J; Cello JP; University of California-San Francisco, USA.
- OBJECTIVE: Diarrhea commonly occurs in persons with human immunodeficiency virus (HIV) infection. The optimal use of endoscopic procedures remains poorly studied for patients with HIV-related diarrhea. The purpose of this study is to compare the diagnostic yield of a complete endoscopic work-up including an esophagoga
- Efficacy of lamivudine in patients with hepatitis B virus precore mutant infection before and after liver transplantation.
- Am J Gastroenterol. 1999 Mar;94(3):663-7. Unique Identifier : AIDSLINE MED/99184452
- Ben-Ari Z; Zemel R; Kazetsker A; Fraser G; Tur-Kaspa R; Liver Institute, Department of Medicine D, Felsenstein Medical; Research Center, Petah Tiqva, Israel.
- OBJECTIVE: Hepatitis B virus (HBV) precore mutant infection is associated with a more severe liver disease and a poorer response to interferon. We evaluated the efficacy and tolerance of lamivudine to induce complete and sustained suppression of viral replication in seven patients infected with HBV precore mutant (HBe
- Prevalence and predictors of severe acute pancreatitis in patients with acquired immune deficiency syndrome (AIDS).
- Am J Gastroenterol. 1999 Mar;94(3):784-9. Unique Identifier : AIDSLINE MED/99184470
- Manocha AP; Sossenheimer M; Martin SP; Sherman KE; Venkatesan T; Whitcomb DC; Ulrich CD 2nd; Department of Medicine, University of Cincinnati Medical Center,; Ohio, USA.
- OBJECTIVE: Recent case control data suggested that a severe course of acute pancreatitis in HIV+ patients was 1) common (50% of cases), 2) poorly predicted by Ranson s criteria (sensitivity 41%), and 3) accurately predicted by a diagnosis of AIDS (positive predictive value 67%). However, the definition of severity inc
- HIV-1 incidence among opiate users in northern Thailand.
- Am J Epidemiol. 1999 Mar 15;149(6):558-64. Unique Identifier : AIDSLINE MED/99181736
- Celentano DD; Hodge MJ; Razak MH; Beyrer C; Kawichai S; Cegielski JP; Nelson KE; Jittiwutikarn J; Department of Epidemiology, The Johns Hopkins University School; of Hygiene and Public Health, Baltimore, MD 21205, USA.
- The incidence of human immunodeficiency virus type 1 (HIV-1) infection among opiate users was determined in a retrospective cohort of 436 patients with multiple admissions to the only inpatient drug treatment program in northern Thailand between October 1993 and September 1995. D
- Production of interferon-gamma by lung lymphocytes in HIV-infected individuals.
- Am J Physiol. 1999 Feb;276(2 Pt 1):L256-62. Unique Identifier : AIDSLINE MED/99137638
- Twigg HL 3rd; Spain BA; Soliman DM; Knox K; Sidner RA; Schnizlein-Bick C; Wilkes DS; Iwamoto GK; Divisions of Pulmonary/Critical Care Medicine and Infectious; Diseases, Department of Medicine, Indiana University Medical; Center, Indianapolis, Indiana 46202, USA.
- A CD8(+) lymphocytic alveolitis occurs in up to 60% of asymptomatic human immunodeficiency virus (HIV)-infected individuals. Early in HIV infection, lymphocytes consist predominantly of cytotoxic T lymphocytes directed against HIV-infected targets. As HIV disease progresses, they are replaced by CD8(+)CD57(+) suppress
- Community-level interventions are needed to prevent new HIV infections [editorial; comment]
- Am J Public Health. 1999 Mar;89(3):299-301. Unique Identifier : AIDSLINE MED/99175772
- Kelly JA
- Community-level HIV intervention in 5 cities: final outcome data from the CDC AIDS Community Demonstration Projects [see comments]
- Unique Identifier : AIDSLINE MED/99175778
- OBJECTIVES: This study evaluated a theory-based community-level intervention to promote progress toward consistent condom and bleach use among selected populations at increased risk for HIV infection in 5 US cities. METHODS: Role-model stories were distributed, along with condoms and bleach, by community members who e
- The human immunodeficiency virus type I Tat protein potentiates ethanol-induced neutrophil functional impairment in transgenic mice.
- Alcohol Clin Exp Res. 1998 Dec;22(9):2043-9. Unique Identifier : AIDSLINE MED/99098618
- Prakash O; Zhang P; Xie M; Ali M; Zhou P; Coleman R; Stoltz DA; Bagby GJ; Shellito JE; Nelson S; Laboratory of Molecular Oncology, Alton Ochsner Medical; Foundation, New Orleans, Louisiana, USA.
- Neutropenia and impairment of neutrophil function are commonly observed in patients with human immunodeficiency virus (HIV) infections. The HIV regulatory protein Tat is known to exert immunosuppressive effects. Alcohol is known also to be an immunosuppressive factor, and as alcohol abuse is common among HIV infected
- Relations among CD4 lymphocyte count nadir, antiretroviral therapy, and HIV-1 disease progression: results from the EuroSIDA study.
- Ann Intern Med. 1999 Apr 6;130(7):570-7. Unique Identifier : AIDSLINE MED/99188830
- Miller V; Mocroft A; Reiss P; Katlama C; Papadopoulos AI; Katzenstein T; van Lunzen J; Antunes F; Phillips AN; Lundgren JD; J.W. Goethe-Universitat, Zentrum der Inneren Medizin, Frankfurt,; Germany. miller@em.uni-frankfurt.de
- BACKGROUND: The effect of previous CD4 cell count nadir on clinical progression in patients with increases in CD4 cell counts has not been investigated. OBJECTIVE: To assess risk for progression of HIV disease in patients with CD4 counts of at least 200 cells/mm3 (stratified by the lowest previous CD4 count) and compa
- Epstein-Barr virus in monitoring the response to therapy of acquired immunodeficiency syndrome-related primary central nervous system lymphoma.
- Ann Neurol. 1999 Feb;45(2):259-61. Unique Identifier : AIDSLINE MED/99142737
- Antinori A; Cingolani A; De Luca A; Gaidano G; Ammassari A; Larocca LM; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy.
- To evaluate the value of Epstein-Barr virus DNA (EBV-DNA) assay in cerebrospinal fluid (CSF) for monitoring the response to treatment in acquired immunodeficiency syndrome-related primary central nervous system lymphoma (AIDS-PCNSL), 9 human immunodeficiency virus-infected patients with biopsy-proven AIDS-PCNSL who un
- Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome.
- Ann Neurol. 1999 Mar;45(3):403-6. Unique Identifier : AIDSLINE MED/99170275
- Pagano MA; Segura MJ; Di Lorenzo GA; Garau ML; Molina HA; Cahn P; Perez H; Vitolo F; Grondona A; Piedimonte FC; Giannaula R; Ramia R; Miranda MA; Sierra H; Sica RE; Department of Neurology, Fernandez Hospital, Buenos Aires,; Argentina.
- Cerebral tumor-like American trypanosomiasis (CTLAT) is an uncommon complication of Chagas disease, observed only in immunosuppressed patients. We assessed 10 human immunodeficiency virus-positive patients with Chagas disease who presented with CTLAT. All patients had neurological involvement and 6 developed intracr
- Social, community, and preventive interventions.
- Unique Identifier : AIDSLINE MED/99174252
- Reppucci ND; Woolard JL; Fried CS
- Psychology can and should be at the forefront of participation in social, community, and preventive interventions. This chapter focuses on selective topics under two general areas: violence as a public health problem and health promotion/competence promotion across the life span. Under violence prevention, discussion
- Identification of a novel bovine serum protein which is involved in human T-cell leukemia virus type I (HTLV-I)-induced syncytium formation.
- Arch Virol. 1999;144(1):1-18. Unique Identifier : AIDSLINE MED/99175801
- Okuma K; Nakamura M; Nakano S; Tanaka Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka, Japan.
- By immunizing rats with cocultured HTLV-I-positive ILT8M2 and HTLV-I-negative MOLT-4-cells, we isolated a monoclonal antibody (mAb), designated as mAb R21, which enhances the syncytium formation induced by coculturing ILT8M2 cells with MOLT-4 cells. The antigen recognized by mAb R21 was found on the surface of all T-c
- Cloning of a long HIV-1 readthrough transcript and detection of an increased level of early growth response protein-1 (Egr-1) mRNA in chronically infected U937 cells.
- Arch Virol. 1999;144(1):19-28. Unique Identifier : AIDSLINE GENBANK/Y12839
- Dron M; Hameau L; Benboudjema L; Guymarho J; Cajean-Feroldi C; Rizza P; Godard C; Jasmin C; Tovey MG; Lang MC; Laboratory of Viral Oncology, C.N.R.S., Villejuif, France.
- To identify the pathways involved in HIV-1 modification of cellular gene expression, chronically infected U937 cells were screened by mRNA differential display. A chimeric transcript consisting of the 3 end of the LTR of a HIV-1 provirus, followed by 3.7 kb of cellular RNA was identified suggesting that long readthro
- Active HIV-1 redistribution and replication in the brain with HIV encephalitis.
- Arch Virol. 1999;144(1):29-43. Unique Identifier : AIDSLINE MED/99175803
- Gatanaga H; Oka S; Ida S; Wakabayashi T; Shioda T; Iwamoto A; Department of Infectious Diseases, Institute of Medical Science,; University of Tokyo, Japan.
- The central nervous system (CNS) is of particular importance in human immunodeficiency virus type 1 (HIV-1) infection. First, the CNS may be difficult to access for anti-retroviral treatment and may become a sanctuary for residual viruses. Second, HIV-1 infection may lead to AIDS demen
- Insertion of sequences into the 3' untranslated region of a replication-competent spleen necrosis virus vector disrupts env gene expression.
- Arch Virol. 1999;144(1):73-87. Unique Identifier : AIDSLINE MED/99175806
- Yin PD; Hu WS; Department of Microbiology and Immunology, West Virginia; University, Morgantown, USA.
- The genomes of all replication-competent retroviruses contain cis-acting elements that regulate gene expression. However, the identities of many of these elements remain to be characterized. Inserting sequences into the 3 untranslated region of a replication-competent spleen necrosis virus (SNV) vector disrupted its
- Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation.
- Biochem Biophys Res Commun. 1999 Feb 24;255(3):591-5. Unique Identifier : AIDSLINE MED/99160397
- Silva CL; Portaro FC; Bonato VL; de Camargo AC; Ferro ES; Department of Parasitology, Microbiology, and Immunology, School; of Medicine of Ribeirao Preto, University of Sao Paulo,; Ribeirao Preto, 14049-900, Brazil.
- The initial processing of antigens leading to major histocompatibility complex (MHC) class I antigenic peptides is carried out by the proteasome. However, how the final epitopes are generated and protected from degradation by cytosolic peptidases remains unknown. Coincidentally, peptides associated with the MHC class
- Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides.
- Biochem Pharmacol. 1999 Apr 1;57(7):775-83. Unique Identifier : AIDSLINE MED/99173378
- Watson K; Gooderham NJ; Davies DS; Edwards RJ; Division of Medicine, Imperial College School of Medicine,; Hammersmith Hospital, London, UK.
- Endogenous sulphated polysaccharides such as heparin have been shown to inhibit the infectivity of HIV-1 min vitro. However, these naturally occurring polymers, due to extensive microheterogeneity within their structure, are difficult to characterise accurately. In contrast, dextrin can be chemically sulphated to prod
- Mechanism of anti-HIV activity of succinylated human serum albumin.
- Biochem Pharmacol. 1999 Apr 15;57(8):889-98. Unique Identifier : AIDSLINE MED/99184126
- Kuipers ME; v.d. Berg M; Swart PJ; Laman JD; Meijer DK; Koppelman MH; Huisman H; Groningen Institute for Drug Studies, The Netherlands.; M.E.Kuipers@farm.rug.nl
- In the present study, we described the interaction of succinylated human serum albumin (Suc-HSA), a negatively charged anti-HIV-1 active protein, with HIV-1 gp120 and in detail with the third variable domain of gp120 (V3 loop). To this end, different assay formats were tested in which gp120- and V3-related peptides we
- Lowering of trichosanthin immunogenicity by site-specific coupling to dextran.
- Biochem Pharmacol. 1999 Apr 15;57(8):927-34. Unique Identifier : AIDSLINE MED/99184131
- Chan WL; Shaw PC; Li XB; Xu QF; He XH; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, NT.
- Trichosanthin is a type I ribosome-inactivating protein possessing a broad spectrum of biological and pharmacological activities. Therapeutic use of this compound is hampered by its immunogenicity. It was shown earlier that coupling of dextran to trichosanthin can increase plasma half-life and reduce antigenicity. How
- Core center opens [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095172
- Heroin use decreases [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095176
- Needle device approved [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095174
- NIAID funds research centers [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095173
- Per-patient cost stabilizes [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095171
- Syringe exchange programs [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095175
- AIDS research and its cultural implications.
- Aids Patient Care STDS. 1998 Dec;12(12):895-902. Unique Identifier : AIDSLINE AIDS/99095177
- Laurence J; Laboratory for AIDS Virus Research, Cornell University Medical; College, New York, New York, USA.
- Successful treatment of idiopathic colitis and proctitis using thalidomide in persons infected with human immunodeficiency virus.
- Aids Patient Care STDS. 1998 Dec;12(12):903-6. Unique Identifier : AIDSLINE AIDS/99095178
- Fu CS; Conteas CN; LaRiviere MJ; Division of Gastroenterology, Southern California Permanente; Medical Group, Los Angeles, USA.
- Gastrointestinal ulcerations in persons infected with HIV have many causes, the most common being opportunistic infections and neoplasms. Recently, idiopathic ulcerative lesions of the colon and rectum have been described. Two cases are reported of idiopathic colonic and anorectal inflammation and ulceration which fai
- Failure of a prospective trial to detect cytomegalovirus retinitis after initiation of highly active antiretroviral therapy.
- Aids Patient Care STDS. 1998 Dec;12(12):907-12. Unique Identifier : AIDSLINE AIDS/99095179
- Uphold CR; Smith MF; Bender BS; Department of Nursing, VA Medical Center, Gainesville, Florida,; USA. Upholcr.ufcon@shands.ufl.edu
- Thirty-one patients with AIDS with CD4+ T-cell counts of less than 75/mm3 were enrolled in a prospective study to determine the incidence of cytomegalovirus ( CMV ) retinitis and changes in CD4+ T-cell counts and viral loads fo
- Acute myeloid leukemias, multiple myelomas, and chronic leukemias in the setting of HIV infection.
- Aids Patient Care STDS. 1998 Dec;12(12):913-9. Unique Identifier : AIDSLINE AIDS/99095180
- Pulik M; Genet P; Jary L; Lionnet F; Jondeau K; Service d'Hematologie, Centre Hospitalier d'Argenteuil, France.
- B-cell lineage-derived high-grade malignant lymphomas are a well-recognized complication of HIV infection. However, isolated cases of unusual hematologic malignancies such as acute myeloid leukemias (AML), multiple myeloma (MM) or plasmacytomas, and chronic leukemias have been reported. This review focuses on these un
- Malignant syphilis: a review.
- Aids Patient Care STDS. 1998 Dec;12(12):921-5. Unique Identifier : AIDSLINE AIDS/99095181
- Kumar B; Muralidhar S; Department of Dermatology, Venereology and Leprology,; Postgraduate Institute of Medical Education and Research,; Chandigarh, India.
- Syphilis is a disorder that may mimic many other diseases. Its incidence has risen and fallen over the centuries. A particularly malignant and virulent form, lues maligna, has recently been more frequently observed in the HIV-infected population. Raising the awareness of the occurrence of and the clinical and laborato
- Psychological adjustment and suicidal ideation in patients with AIDS.
- Aids Patient Care STDS. 1998 Dec;12(12):927-30. Unique Identifier : AIDSLINE AIDS/99095182
- Gil F; Passik S; Rosenfeld B; Breitbart W; Psycho-Oncology Unit, Institut Catala d'Oncologia, L'Hospitalet,; Barcelona, Spain.
- This article assesses the psychosocial adjustment to illness and examines the relationship between adjustment and psychosocial and medical variables in 91 ambulatory HIV-infected patients. The 91 subjects were receiving ambulatory medical care in hospitals (Memorial Hospital, New York Hospital, and St. Vincent s Hospi
- A mobile HIV education and testing program: bringing services to hard-to-reach populations.
- Aids Patient Care STDS. 1998 Dec;12(12):931-7. Unique Identifier : AIDSLINE AIDS/99095183
- O'Connor CA; Patsdaughter CA; Grindel CG; Taveira PF; Steinberg JL; East Boston Neighborhood Health Center, East Boston,; Massachusetts, USA.
- Few programs exist that offer a range of human immunodeficiency virus (HIV) services to multiple populations (i.e., substance abusers, individuals on probation, sex workers and their clients, court-mandated perpetrators of domestic violence) in multiple settings (i.e., courts, methadone maintenance clinics, residentia
- Data released on twice-daily dosing study of saquinavir [news]
- Aids Patient Care STDS. 1998 Dec;12(12):939. Unique Identifier : AIDSLINE AIDS/99095184
- Amprenavir made available through early access program [news]
- Aids Patient Care STDS. 1998 Dec;12(12):939-40. Unique Identifier : AIDSLINE AIDS/99095185
- Protease inhibitor-sparing regimen suppresses HIV [news]
- Aids Patient Care STDS. 1998 Dec;12(12):940. Unique Identifier : AIDSLINE AIDS/99095186
- Indinavir gender study shows consistency [news]
- Aids Patient Care STDS. 1998 Dec;12(12):940-1. Unique Identifier : AIDSLINE AIDS/99095187
- Phase III results presented on amprenavir triple combination [news]
- Aids Patient Care STDS. 1998 Dec;12(12):941-2. Unique Identifier : AIDSLINE AIDS/99095188
- Fomivirsen approved [news]
- Aids Patient Care STDS. 1998 Dec;12(12):943. Unique Identifier : AIDSLINE AIDS/99095189
- Mice immunized against chlamydia [news]
- Aids Patient Care STDS. 1998 Dec;12(12):943. Unique Identifier : AIDSLINE AIDS/99095190
- Famvir effective in suppressing recurrent genital herpes [news]
- Aids Patient Care STDS. 1998 Dec;12(12):944. Unique Identifier : AIDSLINE AIDS/99095191
- Phase II clinical trial of VX-497 for HCV infection begins [news]
- Aids Patient Care STDS. 1998 Dec;12(12):944. Unique Identifier : AIDSLINE AIDS/99095192
- Sexual risk behaviors decrease among high school students.
- Aids Patient Care STDS. 1998 Dec;12(12):945-7. Unique Identifier : AIDSLINE AIDS/99095193
- Makulowich GS
- House passes bill to require HIV tests for all Federal inmates.
- AIDS Policy Law. 1998 Aug 21;13(15):1, 6-8. Unique Identifier : AIDSLINE AIDS/99704106
- Legislation to expand HIV testing in Federal prisons was passed by the House of Representatives on August 3, 1998. The legislation, called H.R. 2070, requires testing of all incoming Federal prisoners and of all inmates who expose corrections officers or visitors to bodily fluids. The legislation does not apply to inm
- A suspicion of AIDS is sufficient to trigger exams for food handlers.
- AIDS Policy Law. 1998 Aug 21;13(15):1, 9. Unique Identifier : AIDSLINE AIDS/99704107
- The Michigan Supreme Court has ruled that food handlers suspected of having AIDS can be required by their employers to undergo testing for opportunistic infections. Such employers are obligated by the Public Health Code and by other food-safety regulations to exclude employees who may transmit opportunistic diseases s
- N.J. court upholds conviction of needle swap volunteers.
- AIDS Policy Law. 1998 Aug 21;13(15):2. Unique Identifier : AIDSLINE AIDS/99704108
- A New Jersey appeals court upheld the convictions of Diana McCague and Thomas Scozzare for possessing drug paraphernalia. They were arrested for trying to distribute sterile injection equipment and bleach to an undercover officer who was posing as a drug addict. Although the defendants argued that needle exchanges sav
- Shared snorkel leads to coerced HIV test, suit alleges.
- AIDS Policy Law. 1998 Aug 21;13(15):3. Unique Identifier : AIDSLINE AIDS/99704109
- An African-American mother is suing an Illinois clinic and a community center, alleging that they pressured her into having her son tested for HIV and strep throat because he shared a snorkel with a white boy at a public swimming pool. The mother contends that the community center pressured her because the white boy s
- House votes to eliminate increased funds for HOPWA.
- AIDS Policy Law. 1998 Aug 21;13(15):4-5. Unique Identifier : AIDSLINE AIDS/99704110
- Congress left for the 1998 summer recess without approving a Labor/Health and Human Services appropriations bill for 1999, which is the funding source for most AIDS programs. The Congress is divided on how much to spend on the Housing Opportunities for People with AIDS (HOPWA) program, and in July, the House shifted $
- House seeks end to needle swaps in District of Columbia.
- AIDS Policy Law. 1998 Aug 21;13(15):5. Unique Identifier : AIDSLINE AIDS/99704111
- If the Senate approves a House-passed spending bill that shuts down all needle-exchange programs in the District of Columbia, it may be vetoed by President Clinton. H.R. 4300, an amendment to the District s appropriations bill by Representative Todd Tiahrt, would prohibit any agency receiving Federal funding from oper
- Report urges collaboration on inmate discharge planning.
- AIDS Policy Law. 1998 Aug 21;13(15):8. Unique Identifier : AIDSLINE AIDS/99704112
- A report from the National Institute of Justice and the Centers for Disease Control and Prevention has recommended that prisons do more discharge planning for HIV-positive inmates being released to the community. Public health and correctional agencies should collaborate more in discharge planning and transitional ser
- HIV levels in semen don't match levels in blood.
- AIDS Policy Law. 1998 Aug 21;13(15):8. Unique Identifier : AIDSLINE AIDS/99704113
- At the World AIDS Conference in Geneva, Phalguni Gupta from the University of Pittsburgh reported that viral load tests on semen are necessary to determine the amount of HIV that can be transmitted during risky sexual contact. Forty-four percent of men involved in a 10-week study had semen viral loads that fluctuated
- HIV-positive plaintiff must show job transfer caused harm.
- AIDS Policy Law. 1998 Aug 21;13(15):10. Unique Identifier : AIDSLINE AIDS/99704114
- A teacher in the De Kalb County School District has argued that the district discriminated against him when they transferred him to a different job because he is HIV-positive. The teacher was transferred from a psychoeducational class that was limited to aggressive and violent special-needs students to a classroom of
- Lawmakers introduce bill for name-based notification.
- AIDS Policy Law. 1998 Aug 21;13(15):10-1. Unique Identifier : AIDSLINE AIDS/99704115
- H.R. 4331, an HIV Partner Protection Act introduced by Reps. Gary Ackerman and Tom Coburn, would require that states report the names of people infected with HIV to the health department. In addition, these people would have to tell public health officials the names of current and past sex or needle-sharing partners.
- Family planning clinic ends required HIV testing.
- AIDS Policy Law. 1998 Aug 21;13(15):11. Unique Identifier : AIDSLINE AIDS/99704116
- The Desire/Florida Neighborhood Pregnancy Care Clinic will no longer require an HIV test as a precondition for obtaining free birth control pills. Previously, women who refused to be tested were referred elsewhere, but those who tested positive were not denied services from the clinic. The policy was changed due to pr
- Measuring HIV treatment adherence in clinical practice.
- AIDS Clin Care. 1998 Aug;10(8):57-9. Unique Identifier : AIDSLINE AIDS/99704117
- Hecht FM
- Measuring adherence to HIV treatment regimens is important in determining whether patients will develop undetectable HIV viremia or drug-resistant HIV. A few methods of measu