Synthesis and anti-virus activity of some nucleosides analogues. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Synthesis and anti-virus activity of some nucleosides analogues.

Z Naturforsch [C]. 1999 Jan-Feb;54(1-2):75-83. Unique Identifier : AIDSLINE MED/99197481
Stankova IG; Simeonov MF; Maximova V; Galabov AS; Golovinsky EV; Department of Chemistry, South-West University Neofit Rilski,; Blagoevgrad, Bulgaria. ivankast@aix.swu.bg

Abstract: New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3a-g) and 3'-, 5'-thymidine (4a-i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modification on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl- and glycyl-glycyl-glycyl- residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only compounds 4d and 4h showed a borderline effect against PsRV.
Keywords: JOURNAL ARTICLE Amino Acids Animal Anti-HIV Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antiviral Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Bromodeoxyuridine/*ANALOGS & DERIVATIVES/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Cells, Cultured Chick Embryo Chickens Drug Design Fibroblasts/CYTOLOGY/VIROLOGY Herpesvirus 1, Human/DRUG EFFECTS Herpesvirus 1, Suid/DRUG EFFECTS Human HIV/DRUG EFFECTS Influenza A Virus, Avian/DRUG EFFECTS Microbial Sensitivity Tests Peptides Structure-Activity Relationship Thymidine/*ANALOGS & DERIVATIVES/CHEMISTRY/*CHEMICAL SYNTHESIS/ PHARMACOLOGYKWDjournalarticleaminoacidsanimalanti-hivagents/chemistry/KWDchemicalsynthesis/pharmacologyantiviralagents/chemistry/KWDchemicalsynthesis/pharmacologybromodeoxyuridine/KWDanalogs&derivatives/chemistry/
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A9971224

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