Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.

BMJ. 1999 Mar 27;318(7187):841-3. Unique Identifier : AIDSLINE MED/99192485
Chitsike I; van Furth R; Departments of Paediatrics and Immunology, Medical School of the; University of Zimbabwe, PO Box A 178, Harare, Zimbabwe.

Abstract: OBJECTIVE: To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV. DESIGN: Case report. SETTING: Teaching hospital in Harare, Zimbabwe. SUBJECTS: A boy of 41/2 years and his mother. MAIN OUTCOME MEASURES: Results of clinical and laboratory investigations. RESULTS: Two weeks after receiving the second dose of oral poliomyelitis vaccine during national immunisation days the child developed paralysis of the right leg. He had a high titre of antibodies against poliovirus type 2, as well as antibodies against HIV-1, a low CD4 count, a ratio of CD4 to CD8 count of 0.47, and hypergammaglobulinaemia. He did not have any antibodies against diphtheria, tetanus, or poliovirus types 1 and 3, although he had been given diphtheria, tetanus, and pertussis and oral polio vaccines during his first year and a booster of the diphtheria, tetanus, and pertussis vaccine at 24 months. He had no clinical symptoms of AIDS, but his mother had AIDS and tuberculosis. CONCLUSION: Paralytic poliomyelitis in this child with HIV infection was caused by poliovirus type 2 after oral poliomyelitis vaccine.
Keywords: JOURNAL ARTICLE Administration, Oral AIDS-Related Opportunistic Infections/*COMPLICATIONS Case Report Child, Preschool Human Male Poliomyelitis/*ETIOLOGY Poliovirus Vaccine/*ADVERSE EFFECTS ZimbabweKWDjournalarticleadministration,oralaids-relatedopportunisticinfections/KWDcomplicationscasereportchild,preschoolhumanmalepoliomyelitis/KWDetiologypoliovirusvaccine/KWDadverseeffectszimbabwe
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