Placental antibody transfer: influence of maternal HIV infection and placental malaria.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Placental antibody transfer: influence of maternal HIV infection and placental malaria.

Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F202-5. Unique Identifier : AIDSLINE MED/99210896
de Moraes-Pinto MI; Verhoeff F; Chimsuku L; Milligan PJ; Wesumperuma L; Broadhead RL; Brabin BJ; Johnson PM; Hart CA; Department of Medical Microbiology, University of Liverpool.

Abstract: AIM: To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer. METHODS: One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG antibody titres using nephelometry, and for specific IgG antibody titres to Streptococcus pneumoniae, measles, and tetanus toxoid antibodies using an enzyme linked immunosorbent assay (ELISA). RESULTS: Multiple regression analyses showed that placental malaria was associated with a decrease in placental IgG antibody transfer to S pneumoniae and measles to 82% and 81%, respectively. Maternal HIV infection was associated with a reduction in IgG antibody transfer to S pneumoniae to 79%; raised maternal total serum IgG titres were correlated with S pneumoniae and measles IgG antibody transfer reduction to 86% and 87%, respectively. No effect was seen with tetanus toxoid antibody transfer. CONCLUSION: The combined influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia seems to be linked to the low transplacental antibody transfer observed in the Malawian population.

Keywords: JOURNAL ARTICLE Adult Antibodies, Bacterial/METABOLISM Antibodies, Viral/METABOLISM Female Human Hypergammaglobulinemia/*IMMUNOLOGY HIV Infections/*IMMUNOLOGY IgG/METABOLISM *Immunity, Maternally-Acquired Infant, Newborn Malaria, Falciparum/*IMMUNOLOGY Malawi Maternal-Fetal Exchange Measles/IMMUNOLOGY Placenta/*IMMUNOLOGY/PARASITOLOGY/VIROLOGY Pregnancy Streptococcus pneumoniae/IMMUNOLOGY Support, Non-U.S. Gov't
990730
A9971192

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