Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats.

J Autoimmun. 1998 Aug;11(4):329-34. Unique Identifier : AIDSLINE MED/98451616
Chelmicka-Schorr E; Wiegmann K; Wollmann R; Arnason BG; Kim DH; Department of Neurology, University of Chicago, 5841 S. Maryland; Avenue, Chicago, IL, 60637, USA.

Abstract: The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onset of EAE shortened the disease. Forty seven days after immunization, extensive demyelination and inflammation were observed in the spinal cords of rats treated with FK 506 from the day of EAE induction. Rats treated after EAE onset had only minimal pathological abnormalities. Copyright 1998 Academic Press
Keywords: JOURNAL ARTICLE Administration, Oral Animal CD4-CD8 Ratio/DRUG EFFECTS Drug Administration Schedule Encephalomyelitis, Allergic/*CHEMICALLY INDUCED/*DRUG THERAPY/ IMMUNOLOGY Female Guinea Pigs Immunosuppressive Agents/*PHARMACOLOGY/*TOXICITY Rats Rats, Inbred Lew Spinal Cord/PATHOLOGY Spleen/CYTOLOGY/DRUG EFFECTS/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocyte Subsets/DRUG EFFECTS Tacrolimus/*PHARMACOLOGY/*TOXICITYKWDjournalarticleadministration,oralanimalcd4-cd8ratio/drugeffectsdrugadministrationscheduleencephalomyelitis,allergic/KWDchemicallyinduced/KWDdrugtherapy/immunologyfemaleguineapigsimmunosuppressiveagents/KWDpharmacology/KWDtoxicityratsrats,inbredlewspinalcord/pathologyspleen/cytology/drugeffects/immunologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytesubsets/drugeffectstacrolimus/KWDpharmacology/KWDtoxicity
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