Anti-apoptotic strategies of lymphotropic viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Anti-apoptotic strategies of lymphotropic viruses.

Immunol Today. 1998 Oct;19(10):474-9. Unique Identifier : AIDSLINE MED/99001851
Meinl E; Fickenscher H; Thome M; Tschopp J; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany. ermeinl@viro.med.uni-erlangen.de

Abstract: Induction of apoptosis of virus-infected cells is an important host cell defence mechanism. However, some viruses have incorporated genes that encode anti-apoptotic proteins or modulate the expression of cellular regulators of apoptosis. Here, Edgar Meinl and colleagues discuss recent evidence that viral interference with host cell apoptosis leads to enhanced viral replication, and to evasion of cytotoxic T-cell effects.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Apoptosis/*PHYSIOLOGY Caspases/METABOLISM Genes, bcl-2 Human HIV/*PHYSIOLOGY HTLV-I/*PHYSIOLOGY Proto-Oncogene Proteins c-bcl-2/PHYSIOLOGY Receptors, Tumor Necrosis Factor/PHYSIOLOGY Support, Non-U.S. Gov't Viral InterferenceKWDjournalarticlereviewreview,tutorialapoptosis/KWDphysiologycaspases/metabolismgenes,bcl-2humanhiv/KWDphysiologyhtlv-i/KWDphysiologyproto-oncogeneproteinsc-bcl-2/physiologyreceptors,tumornecrosisfactor/physiologysupport,non-uKWDsKWDgov'tviralinterference
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A9911087

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