Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.

Biofactors. 1998;8(1-2):129-32. Unique Identifier : AIDSLINE MED/98364176
Jareno EJ; Bosch-Morell F; Fernandez-Delgado R; Donat J; Romero FJ; Department of Physiology, School of Medicine and Dentistry,; University of Valencia, Spain.

Abstract: Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0.515) was found in HIV-infected children between their CD4+ lymphocyte count, and MDA concentration but not with serum antioxidant status. The increase of MDA concentration in HIV-seropositive children confirms the involvement of oxidative stress in the pathophysiology of this infection also in childhood. Because of the importance of oxidative stress and antioxidants for HIV viral replication, the adequacy of an adjuvant therapy with antioxidants should be considered; an adequate candidate for it could be N-acetylcysteine.
Keywords: JOURNAL ARTICLE Biological Markers/BLOOD Child Child, Preschool *CD4 Lymphocyte Count Female Human HIV Seronegativity/PHYSIOLOGY HIV Seropositivity/*BLOOD/*IMMUNOLOGY/PHYSIOPATHOLOGY Male Malondialdehyde/*BLOOD Oxidative Stress Reference Values Regression Analysis Support, Non-U.S. Gov'tKWDjournalarticlebiologicalmarkers/bloodchildchild,preschoolKWDcd4lymphocytecountfemalehumanhivseronegativity/physiologyhivseropositivity/KWDblood/KWDimmunology/physiopathologymalemalondialdehyde/KWDbloodoxidativestressreferencevaluesregressionanalysissupport,non-uKWDsKWDgov't
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