Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics.

AIDS. 1998 Jul 30;12(11):1341-6. Unique Identifier : AIDSLINE MED/98372119
Furrer H; Wendland T; Minder C; Christen A; von Overbeck J; Grunow R; Pichler W; Malinverni RP; AIDS Unit, Medical Policlinic, University of Berne, Switzerland.

Abstract: OBJECTIVES: To study whether syncytium-inducing (SI)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients. DESIGN: Cross-sectional analysis of single centre cohort study data. METHODS: SI/NSI phenotype was determined using a cocultivation assay using patients' peripheral blood mononuclear cells and MT2 cells. Standard procedures were used for CD4+ cell counts and viral load measurements in plasma. Univariate and multivariate analyses of association of CD4+ cell counts, viral load, clinical stage, age, sex and mode of HIV transmission were performed. RESULTS: In univariate analysis, SI phenotype was significantly associated with lower CD4+ cell counts, higher HIV RNA plasma levels, symptomatic HIV disease, male sex and age 32-36 years (middle tercile). In multivariate analysis, only lower CD4+ cell counts were associated with SI phenotype (odds ratio per increase of 100 x 10(6)/l, 0.54; 95% confidence interval, 0.38-0.78). CONCLUSIONS: HIV-1 SI phenotype was associated with lower CD4+ cell counts but not with higher plasma viral load, clinical stage or sociodemographic variables.

Keywords: JOURNAL ARTICLE Adolescence Adult Aged Cohort Studies Cross-Sectional Studies CD4 Lymphocyte Count Demography Female Giant Cells/VIROLOGY Human HIV Infections/IMMUNOLOGY/PHYSIOPATHOLOGY/*VIROLOGY *HIV-1/CLASSIFICATION Male Middle Age Phenotype Support, Non-U.S. Gov't *Viral Load
990130
A9911059

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