Increased cerebrospinal fluid ganglioside GD3 concentrations as a marker of microglial activation in HIV type 1 infection. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Increased cerebrospinal fluid ganglioside GD3 concentrations as a marker of microglial activation in HIV type 1 infection.

AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1065-9. Unique Identifier : AIDSLINE MED/98382248
Andersson LM; Fredman P; Lekman A; Rosengren L; Gisslen M; Department of Infectious Diseases, Institute of Clinical; Neuroscience, Goteborg University, Sweden.

Abstract: Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the infectious course. The predominant, productively infected cell type within the CNS is the microglial cell. We have analyzed the cerebrospinal fluid (CSF) levels of the ganglioside GD3, a microglia/macrophage and astrocyte marker, in 22 HIV-1-infected individuals at different stages of the disease, and in 44 age-matched HIV-negative, healthy controls. To distinguish between microglial/macrophage and astroglial involvement, the GD3 levels were compared with CSF levels of the glial fibrillary acidic protein (GFAp), which is expressed exclusively in astrocytes. A significantly higher mean CSF concentration of GD3 was found in HIV-1-infected patients compared to controls (56.7 and 40.1 nmol/L, respectively, p < 0.001). Seven of 22 HIV-1-infected patients had increased CSF levels of GD3 (above mean + 2 SD in controls), all but one of these had normal levels of GFAp, indicating a microglial activation or proliferation as the major source of the increased GD3 levels.
Keywords: JOURNAL ARTICLE Adult Biological Markers/CEREBROSPINAL FLUID Gangliosides/*CEREBROSPINAL FLUID Glial Fibrillary Acidic Protein/CEREBROSPINAL FLUID Human HIV Infections/*CEREBROSPINAL FLUID/PATHOLOGY Microglia/*PATHOLOGY Middle Age Support, Non-U.S. Gov'tKWDjournalarticleadultbiologicalmarkers/cerebrospinalfluidgangliosides/KWDcerebrospinalfluidglialfibrillaryacidicprotein/cerebrospinalfluidhumanhivinfections/KWDcerebrospinalfluid/pathologymicroglia/KWDpathologymiddleagesupport,non-uKWDsKWDgov't
990130
A9910999

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .