Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine.

AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1079-85. Unique Identifier : AIDSLINE MED/98382250
Novitsky VA; Montano MA; Essex M; Harvard AIDS Institute, Department of Immunology and Infectious; Diseases, Harvard School of Public Health, Boston, Massachusetts; 02115, USA.

Abstract: Phylogenetic characterization of primary isolates from 17 HIV-1-infected individuals within a recent epidemic in the city of Odessa, Ukraine was conducted. The isolates were drawn from two time periods, 1993 and 1996. The 1996 isolates coincided with the first apparent expansion of HIV-1 among injection drug users (IDU). Multi-locus phylogenetic analysis indicated that HIV-1 gag, env, tat, and long terminal repeat (LTR) sequences all conformed to the HIV-1 classification of a subcluster within subtype A. There was no evidence for intersubtype recombinants among these isolates. A number of potential signature sequences, particularly within env, were identified in these two time periods, possibly suggesting a selective pressure on viral evolution among IDU. Results of this study are consistent with a recent introduction and subsequent independent evolution of an HIV-1 subtype A subcluster among IDU in the Southern Ukraine. This study demonstrates a congruence of multi-locus phylogenetic analysis, and suggests that non-B genetic subtypes, such as HIV-1 subtype A, may become relevant to the study of IDU transmission in the future.
Keywords: JOURNAL ARTICLE Amino Acid Sequence Base Sequence DNA Primers Epidemiology, Molecular Genes, Viral Human HIV Infections/*VIROLOGY HIV Long Terminal Repeat HIV-1/*GENETICS Phylogeny Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Substance Abuse, Intravenous/*VIROLOGY Support, U.S. Gov't, P.H.S. UkraineKWDjournalarticleaminoacidsequencebasesequencednaprimersepidemiology,moleculargenes,viralhumanhivinfections/KWDvirologyhivlongterminalrepeathiv-1/KWDgeneticsphylogenysequencehomology,aminoacidsequencehomology,nucleicacidsubstanceabuse,intravenous/KWDvirologysupport,uKWDsKWDgov't,pKWDhKWDsKWDukraine
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