1999

[Complications with permanent damage in endonasal paranasal sinus operations--more frequent in experienced surgeons?]: Laryngorhinootologie. 1998 Jul;77(7):398-401. Unique Identifier : AIDSLINE MED/98416621; Weber R; Keerl R; Hosemann W; Schauss F; Leuwer R; Draf W; Klinik fur HNO-Krankheiten, Kopf-, Hals- und Plastische; Gesichtschirurgie, Kommunikationsstorungen, Klinikum Fulda.; BACKGROUND: The rate of serious complications in endonasal sinus surgery has not gone down although optical aids are widely used nowadays. Are serious complications caused more often by unexperienced or experienced surgeons using a microscope and/or endoscope? METHODS: We defined serious complications as follows: deat
Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental autoimmune neuritis in Lewis rats.: J Autoimmun. 1998 Aug;11(4):319-27. Unique Identifier : AIDSLINE MED/98451615; Zhu J; Bengtsson BO; Mix E; Ekerling L; Thorell LH; Olsson T; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, Stockholm, Sweden. Jie.Zhu@cnsf.ki.se; 5-Hydroxytryptamine (5-HT) reuptake inhibitors of the zimeldine-type have induced polyneuropathies similar to Guillain-Barre syndrome (GBS) in patients with endogenous depression. Some monoamine neurotransmitters have been shown to affect immune reactions in vivo and in vitro in a concentration-dependent manner. We th
Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats.: J Autoimmun. 1998 Aug;11(4):329-34. Unique Identifier : AIDSLINE MED/98451616; Chelmicka-Schorr E; Wiegmann K; Wollmann R; Arnason BG; Kim DH; Department of Neurology, University of Chicago, 5841 S. Maryland; Avenue, Chicago, IL, 60637, USA.; The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse
AIDS talks for adolescents.: World Health Forum. 1998;19(3):294-7. Unique Identifier : AIDSLINE MED/99002232; Manuel C; Molines C; Dubuc M; San Marco JL; Public Health Laboratory, Faculty of Medicine, Universite Aix; Marseille II, France.; The authors discuss how to conduct information sessions on AIDS prevention for adolescents on the basis of experience gained in Marseilles secondary schools. Precautionary messages have to be conveyed without encouraging irrational fear and intolerance.
The immunology of reproduction: update 1998.: Immunol Today. 1998 Oct;19(10):433-4. Unique Identifier : AIDSLINE MED/99001840; Gupta SK; Gamete Antigen Laboratory, National Institute of Immunology,; Aruna Asaf Ali Marg, New Delhi, India.
Granulomatous inflammation and the transmission of infection: schistosomiasis--and TB too?: Immunol Today. 1998 Oct;19(10):462-7. Unique Identifier : AIDSLINE MED/99001849; Doenhoff MJ; School of Biological Sciences, University of Wales, Bangor,; Gwynedd, UK. m.doenhoff@bangor.ac.uk; Immune-dependent granulomatous inflammation is important in the pathogenesis of both schistosomiasis and tuberculosis. A case has previously been made for a role for schistosome egg-induced granulomas in the onward transmission of infection. Here, Mike Doenhoff suggests that a similar hypothesis applies to tuberculosi
Anti-apoptotic strategies of lymphotropic viruses.: Immunol Today. 1998 Oct;19(10):474-9. Unique Identifier : AIDSLINE MED/99001851; Meinl E; Fickenscher H; Thome M; Tschopp J; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany. ermeinl@viro.med.uni-erlangen.de; Induction of apoptosis of virus-infected cells is an important host cell defence mechanism. However, some viruses have incorporated genes that encode anti-apoptotic proteins or modulate the expression of cellular regulators of apoptosis. Here, Edgar Meinl and colleagues discuss recent evidence that viral interference
Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.: Biofactors. 1998;8(1-2):129-32. Unique Identifier : AIDSLINE MED/98364176; Jareno EJ; Bosch-Morell F; Fernandez-Delgado R; Donat J; Romero FJ; Department of Physiology, School of Medicine and Dentistry,; University of Valencia, Spain.; Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0
Role of cysteine and glutathione in signal transduction, immunopathology and cachexia.: Biofactors. 1998;8(1-2):97-102. Unique Identifier : AIDSLINE MED/98364172; Droge W; Hack V; Breitkreutz R; Holm E; Shubinsky G; Schmid E; Galter D; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Abnormally low plasma cystine levels have been found in the late asymptomatic stage of HIV infection and several other diseases associated with progressive loss of skeletal muscle mass. The phenomenon is commonly associated with a low NK cell activity, skeletal muscle wasting or muscle fatigue and increased rates of u
Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3'-azido-2',3'-dideoxythymidine.: Mol Carcinog. 1998 Sep;23(1):45-51. Unique Identifier : AIDSLINE MED/98437827; Zhang Z; Diwan BA; Anderson LM; Logsdon D; Olivero OA; Haines DC; Rice JM; Yuspa SH; Poirier MC; Laboratory of Cellular Carcinogenesis and Tumor Promotion,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892-4255, USA.; This study was designed to evaluate the potential initiating effects of transplacental 3 -azido-2 ,3 -dideoxythymine ( AZT ) and the role of ras mutational activation in skin tumors induced in a two-stage mouse skin model. In addition, mouse liver and l
Crossregulation between Th1 and Th2 cells.: Crit Rev Immunol. 1998;18(4):275-303. Unique Identifier : AIDSLINE MED/98369814; Morel PA; Oriss TB; Department of Medicine, University of Pittsburgh, PA, USA.; Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2 , IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL
Positive and negative thymocyte selection.: Crit Rev Immunol. 1998;18(4):359-70. Unique Identifier : AIDSLINE MED/98369817; Saito T; Watanabe N; Department of Molecular Genetics, Chiba University, Graduate; School of Medicine, Japan.; T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pT alpha and TCR beta chains, which plays a role in allelic exclusion of TCR beta and promotion from DN to DP transition. During the DP stag
T cells in mouse models of gut inflammation.: Chem Immunol. 1998;71:118-38. Unique Identifier : AIDSLINE MED/98448622; Simpson SJ; de Jong YP; Comiskey M; Terhorst C; Division of Immunology, Beth Israel Deaconess Medical Center,; Boston, Mass., USA.
Th1 and Th2 cells and immunity to intestinal helminths.: Chem Immunol. 1998;71:192-208. Unique Identifier : AIDSLINE MED/98448626; Bancroft AJ; Grencis RK; School of Biological Sciences, University of Manchester, UK.; abancrof@fs1.scg.man.ac.uk
Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent.: DNA Cell Biol. 1998 Sep;17(9):735-42. Unique Identifier : AIDSLINE MED/98449462; Zhang L; Chiu J; Lin JC; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.; Human herpesvirus 8 (HHV-8) is a newly discovered virus closely associated with Kaposi s sarcoma and primary effusion lymphomas. When they occur in patients with AIDS, these B-cell lymphomas frequently harbor another human herpesvirus, Epstein-Barr virus (EBV). To determine the molecular mechanisms of the regulation o
Antiretroviral chemotherapy.: Curr Clin Top Infect Dis. 1998;18:154-79. Unique Identifier : AIDSLINE MED/98452390; Saag MS; Schooley RT; Division of Infectious Diseases, University of Alabama at; Birmingham, USA.
Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma.: Curr Clin Top Infect Dis. 1998;18:237-51. Unique Identifier : AIDSLINE MED/98452394; Ganem D; University of California, San Francisco, USA.
New perspectives in adenoviruses.: Curr Clin Top Infect Dis. 1998;18:286-305. Unique Identifier : AIDSLINE MED/98452397; Lukashok SA; Horwitz MS; Emory University School of Medicine, Division of Infectious; Diseases, Atlanta, Georgia, USA.
Infectious tolerance.: Curr Opin Immunol. 1998 Oct;10(5):518-24. Unique Identifier : AIDSLINE MED/99014155; Cobbold S; Waldmann H; Sir William Dunn School of Pathology, South Parks Road, Oxford,; OX1 3RE, UK. stephen.cobbold@pathology.ox.ac.uk; Infectious tolerance can be induced in many ways, does not require a thymus or clonal deletion and can spread to third-party antigens linked on the same antigen-presenting cell-the process being variously described as linked-, bystanderor epitope-suppression. We here review the evidence concerning the mechanisms invol
Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients. NV15355 Study Team.: AIDS. 1998 Jul 30;12(11):F103-9. Unique Identifier : AIDSLINE MED/98372104; Mitsuyasu RT; Skolnik PR; Cohen SR; Conway B; Gill MJ; Jensen PC; Pulvirenti JJ; Slater LN; Schooley RT; Thompson MA; Torres RA; Tsoukas CM; University of California, Los Angeles, USA.; OBJECTIVE: A Phase II, open-label, randomized, parallel-arm, multicentre trial to compare the antiviral activity and safety of two formulations of saquinavir (SQV), soft gelatin (SQV-SGC) and hard gelatin (SQV-HGC) capsules, in combination with two nucleoside reverse transcriptase inhibitors (NRTI), in antiretroviral-
The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy.: AIDS. 1998 Jul 30;12(11):F111-5. Unique Identifier : AIDSLINE MED/98372105; Hoetelmans RM; Reijers MH; Weverling GJ; ten Kate RW; Wit FW; Mulder JW; Weigel HM; Frissen PH; Roos M; Jurriaans S; Schuitemaker H; de Wolf F; Beijnen JH; Lange JM; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; OBJECTIVE: To investigate the relationship between exposure to antiretroviral drugs and the initial decline of plasma HIV-1 RNA. DESIGN: Open-label study in antiretroviral-naive HIV-1 infected patients using a quadruple drug regimen [nelfinavir (NFV), saquinavir (SQV),
Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy.: AIDS. 1998 Jul 30;12(11):F117-22. Unique Identifier : AIDSLINE MED/98372106; Weverling GJ; Lange JM; Jurriaans S; Prins JM; Lukashov VV; Notermans DW; Roos M; Schuitemaker H; Hoetelmans RM; Danner SA; Goudsmit J; de Wolf F; National AIDS Therapy Evaluation Centre, Department of Internal; Medicine, University of Amsterdam, The Netherlands.; OBJECTIVE: To compare the viral suppression of two antiretroviral regimens using three drugs or five drugs. DESIGN: Two open-label studies using a three-drug (zidovudine, lamivudine and ritonavir ) and a five-drug regimen (zidovudine, lamivudine,
Early reduction of immune activation in lymphoid tissue following highly active HIV therapy.: AIDS. 1998 Jul 30;12(11):F123-9. Unique Identifier : AIDSLINE MED/98372107; Andersson J; Fehniger TE; Patterson BK; Pottage J; Agnoli M; Jones P; Behbahani H; Landay A; Division of Infectious Diseases, Karolinska Institute, Stockholm,; Sweden.; OBJECTIVE: To evaluate immune reconstitution within HIV-infected lymphoid tissue during highly active antiretroviral therapy (HAART). DESIGN AND METHODS: In situ cellular responses were studied in sequential tonsillar biopsies in three asymptomatic HIV-infected (CD4 cells greater than 400 x 10(6)/l) antiretroviral tre
Predictors of long-term response to protease inhibitor therapy in a cohort of HIV-infected patients.: AIDS. 1998 Jul 30;12(11):F131-5. Unique Identifier : AIDSLINE MED/98372108; Casado JL; Perez-Elias MJ; Antela A; Sabido R; Marti-Belda P; Dronda F; Blazquez J; Quereda C; Infectious Diseases Unit, Ramon y Cajal Hospital, Madrid, Spain.; OBJECTIVE: To assess the rate of long-term effectiveness and factors associated with response to protease inhibitor therapy in a cohort of HIV-infected patients. DESIGN AND SETTING: Prospective, non-randomized study in a tertiary care centre. PATIENTS: A total of 400 HIV-infected patients who started on protease inhib
Long-term follow-up of randomized trials of immediate versus deferred zidovudine in symptom-free HIV infection. Joint Concorde and Opal Coordinating Committee [editorial]: AIDS. 1998 Jul 30;12(11):1259-65. Unique Identifier : AIDSLINE MED/98372109
Changes in blood CD8+ lymphocyte activation status and plasma HIV RNA levels during antiretroviral therapy.: AIDS. 1998 Jul 30;12(11):1267-73. Unique Identifier : AIDSLINE MED/98372110; Bouscarat F; Levacher M; Landman R; Muffat-Joly M; Girard PM; Saimot AG; Brun-Vezinet F; Sinet M; INSERM Unite 13, Hopital Bichat-Claude Bernard, Paris, France.; OBJECTIVE: To analyse the relationship between CD8+ lymphocyte phenotype alterations and plasma HIV RNA levels in HIV-infected patients treated with the zidovudine-didanosine combination. METHODS: A total of 30 HIV-infected patients who had never received antiretroviral therapy and who were starting treatment with a c
HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.: AIDS. 1998 Jul 30;12(11):1275-84. Unique Identifier : AIDSLINE MED/98372111; Milani D; Mazzoni M; Zauli G; Mischiati C; Gibellini D; Giacca M; Capitani S; Department of Morphology and Embriology, University of Ferrara,; Italy.; OBJECTIVE: To evaluate the signal transduction potential of HIV-1 Tat in a neuronal cell model. METHODS: The tyrosine phosphorylation levels of the focal adhesion kinase p125FAK and its association with phosphoinositide 3-kinase (PI 3-K) were evaluated in serum-starved rat pheochromocytoma PC12 cells, either treated w
Lack of evidence of a stable viral load set-point in early stage asymptomatic patients with chronic HIV-1 infection.: AIDS. 1998 Jul 30;12(11):1285-9. Unique Identifier : AIDSLINE MED/98372112; Vidal C; Garcia F; Romeu J; Ruiz L; Miro JM; Cruceta A; Soriano A; Pumarola T; Clotet B; Gatell JM; Institut d'Investigacions Biomediques August Pi I Sunyer,; Hospital Clinic, Faculty of Medicine, University of Barcelona,; Spain.; OBJECTIVE: To address the question of whether individuals with chronic HIV-1 infection have a stable viral load set-point and to assess the influence of host and viral factors on the evolution of viral load in a subset of stable asymptomatic patients with a baseline viral load below 5000 copies/ml and CD4+ T-cell coun
Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen. DATRI 010 Study Group. Division of AIDS Treatment Research Initiative.: AIDS. 1998 Jul 30;12(11):1291-300. Unique Identifier : AIDSLINE MED/98372113; Bartlett JA; Wasserman SS; Hicks CB; Dodge RT; Weinhold KJ; Tacket CO; Ketter N; Wittek AE; Palker TJ; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; OBJECTIVE: To evaluate the safety and immunogenicity of a polyvalent (PV) HIV envelope synthetic peptide immunogen, C4-V3. The immunogen comprised four peptides containing T-helper epitopes from the fourth constant region (C4) of gp120 of HIV-1MN, and T-helper, cytotoxic T-lymphocyte HLA-B7-restricted, and B-cell neut
Clinical features and outcome in disseminated mycobacterial diseases in AIDS patients in Taiwan.: AIDS. 1998 Jul 30;12(11):1301-7. Unique Identifier : AIDSLINE MED/98372114; Hsieh SM; Hung CC; Chen MY; Hsueh PR; Chang SC; Luh KT; Department of Internal Medicine, National Taiwan University; Hospital, Taipei.; OBJECTIVE: To describe and compare the clinical features and outcome of disseminated tuberculosis (TB) and Mycobacterium avium complex (MAC) disease in AIDS patients. DESIGN: Prospective cohort study. SETTING: A 1800-bed university teaching hospital, the largest centre for HIV/AIDS patients in
Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen.: AIDS. 1998 Jul 30;12(11):1309-15. Unique Identifier : AIDSLINE MED/98372115; Burman WJ; Stone BL; Rietmeijer CA; Maslow J; Cohn DL; Reves RR; Disease Control Service and the Mycobacteriology Laboratory,; Denver Public Health, Colorado 80204, USA.; OBJECTIVES: To describe the long-term outcomes of treatment of AIDS-related Mycobacterium avium complex (MAC) bacteremia using a standard clarithromycin-based regimen. DESIGN: Retrospective study of patients with MAC bacteremia diagnosed between April 1992 and April 1995. SETTING: An urban AIDS clinic SUBJECTS: One hu
Analysis of life-long strategies to prevent Pneumocystis carinii pneumonia in patients with variable HIV progression rates.: AIDS. 1998 Jul 30;12(11):1317-25. Unique Identifier : AIDSLINE MED/98372116; Wynia MK; Ioannidis JP; Lau J; Division of Clinical Care Research, New England Medical Center; Hospitals, Boston, Massachusetts, USA.; OBJECTIVE: To compare strategies for life-long prophylaxis of Pneumocystis carinii pneumonia (PCP) in a group of AIDS patients with a wide range of disease progression rates. DESIGN: Markov decision models. METHODS: Prophylaxis strategies using high and low doses of trimethoprim-sulfamethoxazole (TS), dapsone, and/or
Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication.: AIDS. 1998 Jul 30;12(11):1327-32. Unique Identifier : AIDSLINE MED/98372117; Cinque P; Vago L; Mengozzi M; Torri V; Ceresa D; Vicenzi E; Transidico P; Vagani A; Sozzani S; Mantovani A; Lazzarin A; Poli G; Division of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.; OBJECTIVE: To investigate whether the CC-chemokine monocyte chemotactic protein (MCP)-1 could play a role in the pathogenesis of HIV infection of the central nervous system. This hypothesis was suggested by previous observations, including our finding of elevated cerebrospinal fluid (CSF) levels of this chemokine in p
Clinical experience with adding delavirdine to combination therapy in patients in whom multiple antiretroviral treatment including protease inhibitors has failed.: AIDS. 1998 Jul 30;12(11):1333-40. Unique Identifier : AIDSLINE MED/98372118; Bellman PC; St Vincent's Hospital and Medical Center, Lenox Hill Hospital,; New York, New York, USA.; OBJECTIVE: To determine the effectiveness and safety of adding delavirdine mesylate to a treatment regimen that included indinavir and nucleoside analog reverse transcriptase inhibitors in patients in whom
Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics.: AIDS. 1998 Jul 30;12(11):1341-6. Unique Identifier : AIDSLINE MED/98372119; Furrer H; Wendland T; Minder C; Christen A; von Overbeck J; Grunow R; Pichler W; Malinverni RP; AIDS Unit, Medical Policlinic, University of Berne, Switzerland.; OBJECTIVES: To study whether syncytium-inducing (SI)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients. DESIGN: Cross-sectional analysis of single centre cohort study data.
Immune markers and viral load after HIV-1 seroconversion as predictors of disease progression in a cohort of haemophilic men.: AIDS. 1998 Jul 30;12(11):1347-52. Unique Identifier : AIDSLINE MED/98372120; Sabin CA; Devereux H; Phillips AN; Janossy G; Loveday C; Lee CA; HIV Research Unit, Department of Primary Care and Population; Sciences, Royal Free Hospital and School of Medicine, London, UK.; OBJECTIVE: To assess the prognostic value of HIV RNA levels measured shortly after HIV seroconversion and whether markers of immune response (CD4+ and CD8+ T-cell counts, IgA and IgG) measured at the same time, continue to provide prognostic information once the HIV RNA level is known. DESIGN AND METHODS: HIV RNA leve
Evaluating the effect of year of seroconversion on HIV progression in cohort studies. Italian Seroconversion Study.: AIDS. 1998 Jul 30;12(11):1353-60. Unique Identifier : AIDSLINE MED/98372121; Cozzi Lepri A; Phillips AN; Pezzotti P; Mocroft A; Sabin CA; Porter K; Rezza G; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University Medical; School, University College London, UK.; OBJECTIVES: To show how a spurious association between the calendar year of seroconversion and HIV progression arises as a result of censoring the follow-up of individuals at their last visit, when the individuals visits are intermittent. DESIGN: A notional cohort of 1140 seroconverters and a cohort study of 1270 HIV
Pediatric AIDS prognosis using somatic growth velocity.: AIDS. 1998 Jul 30;12(11):1361-9. Unique Identifier : AIDSLINE MED/98372122; Carey VJ; Yong FH; Frenkel LM; McKinney RE Jr; Channing Laboratory, Harvard Medical School, Boston,; Massachusetts 02115, USA.; OBJECTIVE: To describe the natural history of somatic growth in HIV infection by constructing age-specific growth velocity norms and to assess specific prognostic information available using these norms. DESIGN: Observations on 1338 HIV-infected children aged 3 months to 15 years who participated in one of four US cli
Modelling the costs of paediatric HIV infection and AIDS: comparison of infected children born to screened and unscreened mothers.: AIDS. 1998 Jul 30;12(11):1371-80. Unique Identifier : AIDSLINE MED/98372123; Sculpher MJ; Gibb D; Ades AE; Ratcliffe J; Duong T; Health Economics Research Group, Brunel University, UK.; OBJECTIVE: To estimate the cost of managing children with HIV/AIDS in the UK from a health service perspective. DESIGN AND METHODS: Epidemiological, resource use and unit cost data were combined within a decision analytic model. A Markov model was developed to predict the prognoses of HIV-infected children under diffe
Prevention of mother-to-child transmission of HIV-1 infection: alternative strategies and their cost-effectiveness.: AIDS. 1998 Jul 30;12(11):1381-8. Unique Identifier : AIDSLINE MED/98372124; Ratcliffe J; Ades AE; Gibb D; Sculpher MJ; Briggs AH; Health Economics Research Group, Brunel University, Uxbridge, UK.; OBJECTIVE: To estimate the cost-effectiveness of alternative interventions to reduce the risk of mother-to-child transmission of HIV. DESIGN: A model capturing the sequential nature of mother-to-child transmission in utero, at delivery and postnatally was used to determine how the effects of bottle-feeding, elective C
Women's preferences regarding the formulation of over-the-counter vaginal spermicides [letter]: AIDS. 1998 Jul 30;12(11):1389-91. Unique Identifier : AIDSLINE MED/98372125; Coggins C; Elias CJ; Atisook R; Bassett MT; Ettiegnene-Traore V; Ghys PD; Jenkins-Woelk L; Thongkrajai E; VanDevanter NL
Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T-cell epitopes presented by HLA-B*2703 and B*2705 [letter]: AIDS. 1998 Jul 30;12(11):1391-3. Unique Identifier : AIDSLINE MED/98372126; Rowland-Jones S; Colbert RA; Dong T; McAdam S; Brown M; Ariyoshi K; Sabally S; Whittle H; McMichael A
Marked hypertriglyceridaemia associated with ritonavir therapy [letter]: AIDS. 1998 Jul 30;12(11):1393-4. Unique Identifier : AIDSLINE MED/98372127; Sullivan AK; Feher MD; Nelson MR; Gazzard BG
Indinavir pharmacokinetics in haemodialysis-dependent end-stage renal failure [letter]: AIDS. 1998 Jul 30;12(11):1395. Unique Identifier : AIDSLINE MED/98372128; Guardiola JM; Mangues MA; Domingo P; Martinez E; Barrio JL
Decreased prevalence of intestinal cryptosporidiosis in HIV-infected patients concomitant to the widespread use of protease inhibitors [letter]: AIDS. 1998 Jul 30;12(11):1395-7. Unique Identifier : AIDSLINE MED/98372129; Le Moing V; Bissuel F; Costagliola D; Eid Z; Chapuis F; Molina JM; Salmon-Ceron D; Brasseur P; Leport C
Two successive HIV contaminations from subjects in the window period [letter]: AIDS. 1998 Jul 30;12(11):1397-8. Unique Identifier : AIDSLINE MED/98372130; Laperche S; Moreau P; Lair J; Courouce AM
Rebound of plasma HIV viral load following prolonged suppression with combination therapy [letter]: AIDS. 1998 Jul 30;12(11):1398-9. Unique Identifier : AIDSLINE MED/98372131; Montaner JS; Harris M; Mo T; Harrigan PR
Ketoacidosis associated with protease inhibitor therapy [letter]: AIDS. 1998 Jul 30;12(11):1399-400. Unique Identifier : AIDSLINE MED/98372132; Besson C; Jubault V; Viard JP; Pialoux G
Safety profile of soft gelatin formulation of saquinavir in combination with nucleosides in a broad patient population. NV15182 Study Team [letter]: AIDS. 1998 Jul 30;12(11):1400-2. Unique Identifier : AIDSLINE MED/98372133; Gill MJ
Reply: Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients [letter]: AIDS. 1998 Jul 30;12(11):1402-3. Unique Identifier : AIDSLINE MED/98372134; Fatkenheuer G; Rockstroh J; Salzberger B
HIV seroprevalence and HIV-1 subtype E among pregnant women in Vientiane, Laos [letter]: AIDS. 1998 Jul 30;12(11):1403. Unique Identifier : AIDSLINE MED/98372135; Loue S; Bounlu K; Pholsena V; Mastro TD
Lack of correlation between V3-loop peptide enzyme immunoassay serologic subtyping and genetic sequencing.: AIDS. 1998 Aug 20;12(12):1405-12. Unique Identifier : AIDSLINE MED/98394543; Nkengasong JN; Willems B; Janssens W; Cheingsong-Popov R; Heyndrickx L; Barin F; Ondoa P; Fransen K; Goudsmit J; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; OBJECTIVE: To compare the performance of V3-loop peptide enzyme immunoassay (PEIA) methodologies from four different laboratories for subtyping HIV-1, and to determine the causes for the lack of correlation between V3-loop PEIA serotyping and subtyping by sequencing. MATERIALS AND METHODS: Synthetic peptides derived f
Structure-based design of peptides that recognize the CD4 binding domain of HIV-1 gp120.: AIDS. 1998 Aug 20;12(12):1413-8. Unique Identifier : AIDSLINE MED/98394544; Fontenot JD; Tan X; Phillips DM; Population Council, Center for Biomedical Research, New York, New; York 10021, USA.; DESIGN: Envelope protein-specific antiviral peptides, called mucibodies, that can specifically recognize and bind to the surface unit protein gp120 of HIV-1 were designed. The initial mucibody binding target was the V3 loop of HIV-1 gp120. Here, the gp120-CD4 binding domain was chosen as the site of mucibody binding.
Improved detection of HIV-2 proviral DNA in dually seroreactive individuals by PCR.: AIDS. 1998 Aug 20;12(12):1419-25. Unique Identifier : AIDSLINE MED/98394545; Ishikawa K; Fransen K; Ariyoshi K; Nkengasong JN; Janssens W; Heyndrickx L; Whittle H; Diallo MO; Ghys PD; Coulibaly IM; Greenberg AE; Piedade J; Canas-Ferreira W; van der Groen G; Institute of Tropical Medicine, Antwerp, Belgium.; OBJECTIVE: To improve the detection rate of HIV-2 proviral DNA in primary uncultured peripheral blood mononuclear cells (PBMC) of HIV-2-seroreactive and HIV-1-HIV-2 dually seroreactive individuals. MATERIALS AND METHODS: Two newly designed HIV-2 PCR primer pairs in the long terminal repeat (LTR) gag and gag-pol region
Cytotoxic T-cell responses to HIV-1 reverse transcriptase, integrase and protease.: AIDS. 1998 Aug 20;12(12):1427-36. Unique Identifier : AIDSLINE MED/98394546; Haas G; Samri A; Gomard E; Hosmalin A; Duntze J; Bouley JM; Ihlenfeldt HG; Katlama C; Autran B; Department of Molecular Biology, Max-Planck-Institut fur; Infektionsbiologie, Berlin, Germany.; OBJECTIVES: To determine immunodominant regions and new epitopes for cytotoxic T cells (CTL) directed against the HIV-1 pol products reverse transcriptase (RT), integrase and protease in a large cohort of patients at different stages of disease. DESIGN AND METHODS: Cross-sectional analysis of 98 patients from the Fren
Impairment of B-lymphocyte differentiation induced by dual triggering of the B-cell antigen receptor and CD40 in advanced HIV-1-disease.: AIDS. 1998 Aug 20;12(12):1437-49. Unique Identifier : AIDSLINE MED/98394547; Conge AM; Tarte K; Reynes J; Segondy M; Gerfaux J; Zembala M; Vendrell JP; Centre National Recherche Scientifique, Laboratoire d'Immunologie; des Infections Retrovirales, Institut de Biologie, Montpellier,; France.; OBJECTIVE: This study was performed to investigate the hyporeactivity of purified B lymphocytes from HIV-1-infected patients. DESIGN: Given the importance of the B-cell Ag receptor (BCR) and CD40 in B-lymphocyte activation, we assessed the capacity of purified peripheral blood B lymphocytes from HIV-1-infected patient
Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease.: AIDS. 1998 Aug 20;12(12):1451-7. Unique Identifier : AIDSLINE MED/98394548; Sterling TR; Moore RD; Graham NM; Astemborski J; Vlahov D; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; OBJECTIVE: To determine the relationship between Mycobacterium tuberculosis infection and disease and subsequent disseminated M. avium complex (MAC) disease in HIV-infected persons. DESIGN: A prospective observational cohort study. SETTING: The AIDS Linked to the Intravenous Experience (ALIVE) cohort of injecting drug
Early regression of cervical lesions in HIV-seropositive women receiving highly active antiretroviral therapy.: AIDS. 1998 Aug 20;12(12):1459-64. Unique Identifier : AIDSLINE MED/98394549; Heard I; Schmitz V; Costagliola D; Orth G; Kazatchkine MD; INSERM U 430 and Universite Pierre et Marie Curie, Hopital; Broussais, Paris, France.; OBJECTIVE: Advanced HIV disease is associated with a high prevalence of cervical squamous intra-epithelial lesions (SIL) and of infection with oncogenic human papillomavirus (HPV) genotypes. Triple-combination antiretroviral therapy results in decreased plasma HIV viral load, increased CD4 cell counts and partial rest
Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy.: AIDS. 1998 Aug 20;12(12):1465-74. Unique Identifier : AIDSLINE MED/98394550; Race E; Gilbert SM; Sheldon JG; Rose JS; Moffatt AR; Sitbon G; Dissanayeke SR; Cammack N; Duncan IB; Department of Virology, Roche Discovery Welwyn, Welwyn Garden; City, Hertfordshire, UK.; OBJECTIVES: Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine ( ddC ), to determine the influence of such changes on viral phenotype and response to treatment. D
Kaposi's sarcoma in HIV infection: impact on opportunistic infections and survival.: AIDS. 1998 Aug 20;12(12):1475-81. Unique Identifier : AIDSLINE MED/98394551; Brodt HR; Kamps BS; Helm EB; Schofer H; Mitrou P; Medizinische Klinik III/Infektiologie, Frankfurt, Germany.; OBJECTIVE: To determine the effect of Kaposi s sarcoma on survival of HIV-infected patients. METHODS: Retrospective cohort study to compare the survival of 241 HIV-infected homosexual patients with Kaposi s sarcoma (cases) with that of 241 HIV-infected homosexual patients without Kaposi s sarcoma (control subjects) bu
Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen.: AIDS. 1998 Aug 20;12(12):1483-90. Unique Identifier : AIDSLINE MED/98394552; Notermans DW; Goudsmit J; Danner SA; de Wolf F; Perelson AS; Mittler J; Department of Human Retrovirology, University of Amsterdam, The; Netherlands.; OBJECTIVES AND DESIGN: The dynamics uf viral decline following the initiation of antiretroviral treatment were studied in 29 HIV-1-infected patients participating in a two-arm trial comparing immediate (group A: ritonavir , zidovudine and lamivudine) a
HIV combination therapy: partial immune restitution unmasking latent cryptococcal infection.: AIDS. 1998 Aug 20;12(12):1491-4. Unique Identifier : AIDSLINE MED/98394553; Woods ML 2nd; MacGinley R; Eisen DP; Allworth AM; Infectious Diseases Unit, Wattlebrae, Royal Brisbane Hospital,; Herston, Queensland, Australia.; OBJECTIVE: To describe two cases of cryptococcal meningitis and one re-exacerbation of Cryptococcus-associated meningitis occurring in temporal association with commencement of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection (CD4 cells
A randomized trial of the effect of ritonavir in maintaining quality of life in advanced HIV disease. Advanced HIV Disease Ritonavir Study Group.: AIDS. 1998 Aug 20;12(12):1495-502. Unique Identifier : AIDSLINE MED/98394554; Cohen C; Revicki DA; Nabulsi A; Sarocco PW; Jiang P; Community Research Initiative of New England, Brookline,; Massachusetts, USA.; BACKGROUND: The aim of treatment for HIV disease is prolonging survival and improvement in health-related quality of life. Ritonavir is a potent, orally bioavailable HIV protease inhibitor with demonstrated impact on surrogate endpoints, AIDS-defining
Preventing Mycobacterium avium complex in patients who are using protease inhibitors: a cost-effectiveness analysis.: AIDS. 1998 Aug 20;12(12):1503-12. Unique Identifier : AIDSLINE MED/98394555; Bayoumi AM; Redelmeier DA; Department of Medicine, University of Toronto, Canada.; BACKGROUND: Practice guidelines recommending Mycobacterium avium complex (MAC) prophylaxis for patients with HIV disease were based on clinical trials in which individuals did not receive protease inhibitors . OBJECTIVE: To estimate the cost-effectiveness of strategi
An open randomized controlled trial of zidovudine plus lamivudine versus stavudine plus lamivudine.: AIDS. 1998 Aug 20;12(12):1513-9. Unique Identifier : AIDSLINE MED/98394556; Foudraine NA; de Jong JJ; Jan Weverling G; van Benthem BH; Maas J; Keet IP; Jurriaans S; Roos MT; Vandermeulen K; de Wolf F; Lange JM; Department of Public Health and Environment, Academic Medical; Centre, University of Amsterdam, The Netherlands.; OBJECTIVE: To compare the antiretroviral effect and safety of zidovudine (ZDV)-lamivudine ( 3TC ) with that of stavudine (
Effect of HIV-specific immune-based therapy in subjects infected with HIV-1 subtype E in Thailand.: AIDS. 1998 Aug 20;12(12):1521-7. Unique Identifier : AIDSLINE MED/98394557; Churdboonchart V; Moss RB; Sirawaraporn W; Smutharaks B; Sutthent R; Jensen FC; Vacharak P; Grimes J; Theofan G; Carlo DJ; Mahidol University, Phayathai, Bangkok, Thailand.; OBJECTIVE: To examine the effect of treatment with an inactivated, gp120-depleted, HIV-1 immunogen (Remune) in 30 Thai subjects infected with HIV-1 subtype E. DESIGN: Sixty-week open-label study. METHODS: Thirty HIV-positive volunteers with CD4 cell counts > or = 300 x 10(6)/l were given intramuscular injections of Re
Social network dynamics and HIV transmission.: AIDS. 1998 Aug 20;12(12):1529-36. Unique Identifier : AIDSLINE MED/98394558; Rothenberg RB; Potterat JJ; Woodhouse DE; Muth SQ; Darrow WW; Klovdahl AS; Department of Family and Preventive Medicine, Emory University; School of Medicine, Atlanta, GA 30303-3219, USA.; OBJECTIVE: To prospectively study changes in the social networks of persons at presumably high risk for HIV in a community with low prevalence and little endogenous transmission. METHODS: From a cohort of 595 persons at high risk (prostitutes, injecting drug users, and sexual partners of these persons) and nearly 6000
The incubation period to AIDS in injecting drug users estimated from prevalent cohort data, accounting for death prior to an AIDS diagnosis.: AIDS. 1998 Aug 20;12(12):1537-44. Unique Identifier : AIDSLINE MED/98394559; Hendriks JC; Satten GA; van Ameijden EJ; van Druten HA; Coutinho RA; van Griensven GJ; Department of Public Health, Municipal Health Service, Amsterdam,; The Netherlands.; OBJECTIVE: To estimate the incubation-period distribution (time from seroconversion to AIDS) accounting for death before an AIDS diagnosis (DBAD) in a cohort of injecting drug users (IDU) in Amsterdam, The Netherlands and to compare these estimates with those previously obtain
Sensitivity and specificity of a qualitative RNA detection assay to diagnose HIV infection in young infants. Perinatal AIDS Collaborative Transmission Study.: AIDS. 1998 Aug 20;12(12):1545-9. Unique Identifier : AIDSLINE MED/98394560; Simonds RJ; Brown TM; Thea DM; Orloff SL; Steketee RW; Lee FK; Palumbo PE; Kalish ML; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To evaluate the sensitivity and specificity of an RNA detection assay for diagnosing perinatal HIV infection. METHODS: Plasma and serum specimens taken during the first 3 months of life from HIV-infected and uninfected children enrolled in a cohort study were assayed for HIV RNA using the qualitative nuclei
Taenia crassiceps cysticercosis and AIDS [letter]: AIDS. 1998 Aug 20;12(12):1551-2. Unique Identifier : AIDSLINE MED/98394561; Maillard H; Marionneau J; Prophette B; Boyer E; Celerier P
Combination antiretroviral therapy for HIV infection: policies and practices [letter]: AIDS. 1998 Aug 20;12(12):1552-3. Unique Identifier : AIDSLINE MED/98394562; Lansky A; Ward JW; Jones JL
Serum antibodies to dietary antigens in patients with HIV-1 infection [letter]: AIDS. 1998 Aug 20;12(12):1553-5. Unique Identifier : AIDSLINE MED/98394563; Wahnschaffe U; Zippel T; Schmidt W; Schneider T; Schulzke JD; Riecken EO; Ullrich R
Once weekly azithromycin as prophylaxis against recurrence of non-tuberculous mycobacterial infections in HIV-1-positive individuals [letter]: AIDS. 1998 Aug 20;12(12):1555-7. Unique Identifier : AIDSLINE MED/98394564; Moyle GJ; Gill J; Nelson M
Decline of anti-DP107 antibody associated with clinical progression [letter]: AIDS. 1998 Aug 20;12(12):1557-9. Unique Identifier : AIDSLINE MED/98394565; Hattori T; Komoda H; Pahwa S; Tateyama M; Zhang X; Xu Y; Oguma S; Tamamura H; Fujii N; Fukutake K; Uchiyama T
Partner notification in newly diagnosed HIV-positive patients [letter]: AIDS. 1998 Aug 20;12(12):1559-60. Unique Identifier : AIDSLINE MED/98394566; Elliott SA; Ahmad S; Ross JD
Who may be engaging in high-risk sex due to medical treatment advances? [letter]: AIDS. 1998 Aug 20;12(12):1560-1. Unique Identifier : AIDSLINE MED/98394567; Remien RH; Wagner G; Carballo-Dieguez A; Dolezal C
Four novel cytotoxic T-lymphocyte epitopes in the highly conserved major homology region of HIV-1 Gag, restricted through B*4402, B*1801, A*2601, B*70 (B*1509) [letter]: AIDS. 1998 Aug 20;12(12):1561-3. Unique Identifier : AIDSLINE MED/98394568; Ogg GS; Dong T; Hansasuta P; Dorrell L; Clarke J; Coker R; Luzzi G; Conlon C; McMichael AP; Rowland-Jones S
HIV-1 subtypes in Santiago, Chile [letter]: AIDS. 1998 Aug 20;12(12):1563-5. Unique Identifier : AIDSLINE MED/98394569; Desgranges C; Fillon S; Letourneur F; Buzelay L; Sepulveda C; Guzman MA; Afani A; Barin F; Saragosti S
HIV-1 group O virus infection in Abidjan, Cote d'Ivoire [letter]: AIDS. 1998 Aug 20;12(12):1565-6. Unique Identifier : AIDSLINE MED/98394570; Nkengasong J; Sylla-Koko F; Peeters M; Ellenberger D; Sassan-Morokro M; Ekpini RA; Msellati P; Greenberg AE; Combe P; Rayfield M
Distribution of pyranocoumarins in Calophyllum cordato-oblongum.: Phytochemistry. 1998 Oct;49(4):995-8. Unique Identifier : AIDSLINE MED/99004414; Dharmaratne HR; Mayuri Sajeevani JR; Marasinghe GP; Shantha Ekanayake EM; Natural Products Programme, Institute of Fundamental Studies,; Kandy, Sri Lanka.; Twigs of Calophyllum cordato-oblongum have been shown to contain a new pyranocoumarin, the methyl ether of cordatolide B, three reported pyranocoumarins, cordato-oblongic acid, friedelin, canophyllol and taraxerol. Buds of this species contained large quantities of pyranocoumarins and a small amount of sitosterol. Thi
Effects of beta2 adrenoceptor agonists on T-cell subpopulations.: APMIS. 1998 Sep;106(9):849-57. Unique Identifier : AIDSLINE MED/99023597; Holen E; Elsayed S; Allergy Research Group, Department of Clinical Biochemistry,; University Hospital, Bergen, Norway.; The aim of the present communication is to determine the effects of beta2 adrenoceptor agonists on growth and cytokine secretion using allergen-specific T cells. Four beta2 adrenoceptor agonists were administered at therapeutically relevant doses (salbutamol 1-2 microM; salmeterol 0.03-0.06 microM; terbutaline 0.56-1.
Sticky-end PCR: new method for subcloning.: Biotechniques. 1998 Aug;25(2):206-8. Unique Identifier : AIDSLINE MED/98380586; Zeng G; Georgetown University Medical Center Washington, DC, USA.
Fission yeast expression vectors adapted for positive identification of gene insertion and green fluorescent protein fusion.: Biotechniques. 1998 Sep;25(3):438-40, 442, 444. Unique Identifier : AIDSLINE GENBANK/AF064067; Zhao Y; Elder RT; Chen M; Cao J; Children's Memorial Institute of Education and Research, Chicago,; IL 60614, USA.; A pYZ series of fission yeast expression vectors, derivatives of the pREP series, was designed to allow positive identification of cloned gene insertion and fusion to the green fluorescent protein (GFP) gene for in vivo analysis of gene expression. To validate this new vector system, the human immunodeficiency virus t
Quantitation of mixed-base populations of HIV-1 variants by automated DNA sequencing with BODIPY dye-labeled primers.: Biotechniques. 1998 Sep;25(3):446-7, 450-2, 454, passim. Unique Identifier : AIDSLINE MED/98435191; Metzker ML; Ansari-Lari MA; Liu XM; Holder DJ; Gibbs RA; Baylor College of Medicine, Houston, TX, USA.; Direct DNA sequencing of human immunodeficiency virus type 1 (HIV-1) pol and env gene regions was characterized for accuracy and precision. Restricted maximum likelihood (REML) analysis of molecular clone reconstruction experiments using a primer-walking strategy showed that the BODIPY and BODIPY energy-transfer (BET)
Mutation typing using electrophoresis and gel-immobilized Acrydite probes.: Biotechniques. 1998 Sep;25(3):516-21. Unique Identifier : AIDSLINE MED/98435197; Kenney M; Ray S; Boles TC; Mosaic Technologies, Inc., Boston, MA, USA.; A new electrophoresis technology for hybridization-based sequence detection and mutation typing is described. Intrinsic to this approach is copolymerization of specially modified oligonucleotide probes directly into polyacrylamide gels. Electrophoresis of single-stranded samples through gels containing specific immobi
A protocol-contract for opioid use in patients with chronic pain not due to malignancy.: J Clin Anesth. 1998 Aug;10(5):435-43. Unique Identifier : AIDSLINE MED/98368010; Kirkpatrick AF; Derasari M; Kovacs PL; Lamb BD; Miller R; Reading A; Department of Anesthesiology, University of South Florida College; of Medicine, Tampa 33612-4799, USA.; The legal, psychosocial, and medical factors that we believe have contributed to the success of our protocol-contract in prescribing opioids to patients with chronic pain not due to malignancy are outlined. These factors may be applicable to the treatment of a variety of chronic nonmalignant pain syndromes such as pos
Development and testing of an HIV-risk screening instrument for use in health care settings.: Am J Prev Med. 1998 Aug;15(2):103-13. Unique Identifier : AIDSLINE MED/98379287; Gerbert B; Bronstone A; McPhee S; Pantilat S; Allerton M; Division of Behavioral Sciences, School of Dentistry, University; of California, San Francisco 94111, USA.; OBJECTIVE: To develop and test a brief, reliable, and valid HIV-risk screening instrument for use in primary health care settings. DESIGN: A two-phase study: (1) developing a self-administered HIV-risk screening instrument, and (2) testing it with a primary care population, including testing the effect of confidential
Comparison of simulated patient and didactic methods of teaching HIV risk assessment to medical residents.: Am J Prev Med. 1998 Aug;15(2):114-9. Unique Identifier : AIDSLINE MED/98379288; Madan AK; Caruso BA; Lopes JE; Gracely EJ; Department of Surgery, Tulane University Medical Center, New; Orleans, Louisiana 70112, USA.; INTRODUCTION: Physicians need to be well trained in HIV risk assessment interview skills. Little has been written in the literature concerning training methods for this specialized interview. METHODS: One model to teach the HIV risk assessment interview has been developed and has been used to teach third-year medical
Post-exposure prophylaxis for HIV infection in gay and bisexual men. Implications for the future of HIV prevention.: Am J Prev Med. 1998 Aug;15(2):120-7. Unique Identifier : AIDSLINE MED/98379289; Kalichman SC; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA.; OBJECTIVE: To assess the psychological and behavioral characteristics of gay and bisexual men who intend to use antiretroviral post-exposure prophylaxis (PEP) to prevent HIV infection. METHODS: Gay and bisexual men who had not tested HIV seropositive and were not in long-term exclusive sexual relationships (n = 327) c
Fine specificity of anti-V3 antibodies induced in chimpanzees by HIV candidate vaccines.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1023-34. Unique Identifier : AIDSLINE MED/98382243; Coeffier E; Girard M; Barre-Sinoussi F; Meignier B; Muchmore E; Fultz PN; LeClerc C; Unite de Biologie des Regulations Immunitaires, Institut; Pasteur, Paris, France. coeffier@pasteur.fr; The fine specificity of the anti-V3 antibody responses induced in chimpanzees immunized by various human immunodeficiency type 1 (HIV-1) candidate vaccines and challenged by heterologous strains of HIV-1 was analyzed by enzyme-linked immunosorbent assay (ELISA) and Pepscan epitope mapping. Two chimpanzees immunized wi
Neutralizing antibodies administered before, but not after, virulent SHIV prevent infection in macaques.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1035-43. Unique Identifier : AIDSLINE MED/98382244; Foresman L; Jia F; Li Z; Wang C; Stephens EB; Sahni M; Narayan O; Joag SV; Department of Microbiology, University of Kansas Medical Center,; Kansas City 66160-7424, USA.; By subcutaneous inoculation of SHIV(KU-2) in the hands of macaques, we developed a model of human immunodeficiency virus type-1 (HIV-1) occupational infection due to needle-stick injury and used the model to determine whether neutralizing serum to SHIV administered before or after virus inoculation could either preven
Failure of SIVmac to be neutralized in macrophage cultures is unique to SIVmac and not observed with neutralization of SHIV or HIV-1.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1045-51. Unique Identifier : AIDSLINE MED/98382245; Zhuge W; Jia F; Stephens EB; Li Z; Wang C; Joag SV; Narayan O; Department of Microbiology, Molecular Genetics and Immunology,; University of Kansas Medical Center, Kansas City 66160-7424, USA.; wzhuge@kumc.edu; Except during acutely lethal infection, macaques infected with SIVmac251 produce antibodies that neutralize the virus in CEMx174 cells, macaque PBMC and macrophage cultures. In a previous report, we had shown that whereas neutralization of the SIVmac251 was complete in lymphocyte cultures, protected macrophages had
Cellular proviral HIV type 1 DNA load persists after long-term RT-inhibitor therapy in HIV type 1 infected persons.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1053-8. Unique Identifier : AIDSLINE MED/98382246; Bruisten SM; Reiss P; Loeliger AE; van Swieten P; Schuurman R; Boucher CA; Weverling GJ; Huisman JG; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Department of Clinical Viro-Immunology, Amsterdam.; In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine ( AZT ) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanos
Impaired fitness of foscarnet-resistant strains of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1059-64. Unique Identifier : AIDSLINE MED/98382247; Tachedjian G; Mellors JW; Bazmi H; Mills J; National Centre in HIV Virology Research, Macfarlane Burnet; Centre for Medical Research, Fairfield, Australia.; Foscarnet (PFA) is a pyrophosphate analogue antiviral active against human immunodeficiency virus (HIV-1) and herpesviruses. Strains of HIV-1 resistant to PFA have mutations in the HIV-1 reverse transcriptase (RT). We examined the influence of PFA resistance mutations, in different genetic backgrounds, on HIV-1 replic
Increased cerebrospinal fluid ganglioside GD3 concentrations as a marker of microglial activation in HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1065-9. Unique Identifier : AIDSLINE MED/98382248; Andersson LM; Fredman P; Lekman A; Rosengren L; Gisslen M; Department of Infectious Diseases, Institute of Clinical; Neuroscience, Goteborg University, Sweden.; Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the infectious course. The predominant, productively infected cell type within the CNS is the microglial cell. We have analyzed the cerebrospinal fluid (CSF) levels of the ganglioside GD3, a microglia/macrophage and astrocyte
Cardiac involvement in the acquired immunodeficiency syndrome: a multicenter clinical-pathological study. Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS Investigators.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1071-7. Unique Identifier : AIDSLINE MED/98382249; Barbaro G; Di Lorenzo G; Grisorio B; Barbarini G; Department of Emergency Medicine University La Sapienza, Rome,; Italy.; The heart is frequently involved in the acquired immunodeficiency syndrome (AIDS). This study was planned to assess the prevalence of cardiac involvement in a large and selected population of patients who died of AIDS. Of 440 AIDS patients who underwent autopsy, cardiac involvement was documented in 82 patients. Dilat
Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1079-85. Unique Identifier : AIDSLINE MED/98382250; Novitsky VA; Montano MA; Essex M; Harvard AIDS Institute, Department of Immunology and Infectious; Diseases, Harvard School of Public Health, Boston, Massachusetts; 02115, USA.; Phylogenetic characterization of primary isolates from 17 HIV-1-infected individuals within a recent epidemic in the city of Odessa, Ukraine was conducted. The isolates were drawn from two time periods, 1993 and 1996. The 1996 isolates coincided with the first apparent expansion o
Feline immunodeficiency virus is shed in semen from experimentally and naturally infected cats.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1087-92. Unique Identifier : AIDSLINE MED/98382251; Jordan HL; Howard J; Barr MC; Kennedy-Stoskopf S; Levy JK; Tompkins WA; Harvard Medical School, Division of Viral Pathogenesis, Beth; Israel Deaconess Medical Center, Boston, Massachusetts 02215,; USA.; Although a laboratory isolate of feline immunodeficiency virus (FIV), FIV-NCSU1, has been transmitted by artificial insemination in domestic cats, transmission by naturally infected males during mating has not been reported. In order to determine whether virus shedding in semen is unique to the NCSU1 isolate, we analy
Identification of novel human endogenous retroviral sequences belonging to the HERV-K family.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1093-8. Unique Identifier : AIDSLINE MED/98382252; Zsiros J; Jebbink MF; Voute PA; Berkhout B; Department of Pediatric Oncology, Academic Medical Center,; University of Amsterdam, The Netherlands.
HIV type 1 subtypes of nonhemophiliac patients in Japan.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1099-103. Unique Identifier : AIDSLINE MED/98382253; Kitsutani PT; Naganawa S; Shiino T; Matsuda M; Honda M; Yamada K; Taki M; Sugiura W; National Institute of Infectious Diseases, AIDS Research Center,; Tokyo, Japan.
Human immunodeficiency virus type 1 subtypes B and C detected in New Zealand.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1105-8. Unique Identifier : AIDSLINE MED/98382254; Dwyer DE; Herring BL; Ge YC; Bolton WV; Ellis-Pegler RB; Thomas M; Schroeder BA; Croxson MC; Cunningham AL; Mullins JI; Saksena NK; Centre for Virus Research, Westmead Institutes of Health; Research, ICPMR, Westmead Hospital, Australia.; dominicd@westmed.wh.usyd.edu.au
HIV and AIDS information on the Internet.: J Am Acad Nurse Pract. 1998 Apr;10(4):173-4. Unique Identifier : AIDSLINE MED/99018359; Korn K; Student Health Service, University of South Dakota, Vermillion,; USA.
[Idiopathic CD4+ lymphocytopenia: a clinico-immunological syndrome of uncertain significance (editorial; comment)]: Ann Ital Med Int. 1997 Oct-Dec;12(4):197-8. Unique Identifier : AIDSLINE MED/98446749; Dammacco F
Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers.: Br J Clin Pharmacol. 1998 Aug;46(2):111-6. Unique Identifier : AIDSLINE MED/98389211; Ouellet D; Hsu A; Qian J; Locke CS; Eason CJ; Cavanaugh JH; Leonard JM; Granneman GR; Abbott Laboratories, Abbott Park, IL 60064-3500, USA.; AIMS: To assess the effects of the protease inhibitor ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers. METHODS: This was an open-label, single centre study in 23 subjects who received two single doses of oral contr
Costs and cost-effectiveness of new technologies in cancer.: Cancer Treat Res. 1998;97:25-36. Unique Identifier : AIDSLINE MED/98377266; Waters TM; Institute for Health Services Research & Policy Studies,; Northwestern University, Evanston, IL 60208, USA.
Infectious arthritis and immune dysfunction.: Curr Opin Rheumatol. 1998 Jul;10(4):B139-46. Unique Identifier : AIDSLINE MED/98392726
Bacterial arthritis.: Curr Opin Rheumatol. 1998 Jul;10(4):330-4. Unique Identifier : AIDSLINE MED/98392715; Ike RW; Rheumatology Division, University of Michigan Medical Center, Ann; Arbor 48109-0358, USA.; Reports pertinent to bacterial arthritis in 1997 included two large, multi-year surveys of joint infection in patients from defined European health districts, noting trends including the declining incidence of gonococcal arthritis and an increasing number of prosthetic joint infections. Children with infected joints g
Retrovirus-associated rheumatic syndromes.: Curr Opin Rheumatol. 1998 Jul;10(4):347-54. Unique Identifier : AIDSLINE MED/98392718; Herrmann M; Neidhart M; Gay S; Hagenhofer M; Kalden JR; Friedrich-Alexander University of Erlangen-Nuremberg, Department; of Internal Medicine III, Germany.; The influence of environmental factors in the initiation of autoimmune rheumatic diseases is still under debate. Infections with viruses (e.g., retroviruses) or expression of gene products encoded by endogenous retroviruses are believed to contribute to both loss of tolerance for autoantigens and immunosuppression. In
Recommendations on the safe and effective use of short-course ZDV for prevention of mother-to-child transmission of HIV.: Wkly Epidemiol Rec. 1998 Oct 9;73(41):313-20. Unique Identifier : AIDSLINE MED/99011670
In it together.: Nurs Stand. 1998 Aug 12-18;12(47):18. Unique Identifier : AIDSLINE MED/98424703; Pinching A; Medical College of St Bartholomew's Hospital.
Low CD4 counts rather than superantigenic-like effects account for differences in expressed T-cell receptor (TCR) repertoires between HIV-1 seropositive long-term non-progressors and individuals with progressive disease.: Br J Haematol. 1998 Sep;102(5):1187-96. Unique Identifier : AIDSLINE MED/98423966; Westby M; Vaughan AN; Balotta C; Galli M; Clerici M; Dalgleish AG; Division of Oncology, Cellular and Molecular Sciences, St; George's Hospital Medical School, London, UK.; Analysis of HIV-infected individuals who have stable CD4 counts many years after seroconversion may provide an insight as to how the host s immune system can successfully control HIV infection. In this study we analysed the T-cell receptor (TCR) Vbeta repertoire in 13 HIV+ individuals, seven of whom were classed as lo
Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles.: Br J Haematol. 1998 Sep;102(5):1314-22. Unique Identifier : AIDSLINE MED/98423984; Molldrem JJ; Jiang YZ; Stetler-Stevenson M; Mavroudis D; Hensel N; Barrett AJ; Department of Blood and Marrow Transplantation, University of; Texas M. D. Anderson Cancer Center, Houston 77030, USA.; We have demonstrated that 44% of myelodysplastic syndrome (MDS) patients with cytopenia have a haematological response to antithymocyte globulin (ATG). Three ATG responders and two non-responders with refractory anaemia were further studied for lymphocyte-mediated inhibition of bone marrow using a standard CFU-GM assa
Dendritic cells derived from bone marrow and CD34+ selected blood progenitor cells of myeloma patients, cultured in serum-free media, do not contain the Kaposi sarcoma herpesvirus genome.: Br J Haematol. 1998 Sep;102(5):1338-40. Unique Identifier : AIDSLINE MED/98423989; Mitterer M; Mair W; Gatti D; Sheldon J; Vachula M; Coser P; Schultz TF; Department of Haematology and Bone Marrow Transplantation Centre,; Bozen/Bolzano, Italy.; The aim of our study was to test if dendritic cells contain the KSHV genome. CD34+ peripheral blood progenitor cells (PBPC) and bone marrow mononuclear cells were cultured in X-VIVO 15 medium supplemented with GM-CSF and TNF-alpha in gas-permeable containers. Dendritic cells were identified morphologically and immunop
Development of autoantibodies and factor VIII inhibitor in an HIV-infected haemophiliac following treatment with combination anti-retroviral therapy [letter]: Br J Haematol. 1998 Sep;102(5):1382-3. Unique Identifier : AIDSLINE MED/98423999; Evans GD; Mendelson GM; Lever AM; Baglin TP
Two cases of cerebral aneurysms in HIV+ children.: Pediatr Neurosurg. 1998 Jan;28(1):31-4. Unique Identifier : AIDSLINE MED/98376112; Fulmer BB; Dillard SC; Musulman EM; Palmer CA; Oakes J; Division of Neurosurgery, University of Alabama at Birmingham,; USA.; Two cases of fusiform cerebral aneurysms in human immunodeficiency virus (HIV) positive children are presented. To our knowledge, only 9 patients with this association have been reported. One of our patients represents the first report of a patient with an aneurysm associated with varicella-zoster vasculitis. One pati
The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin.: Ann Oncol. 1998 Jul;9(7):711-6. Unique Identifier : AIDSLINE MED/98411752; Berry G; Billingham M; Alderman E; Richardson P; Torti F; Lum B; Patek A; Martin FJ; Department of Surgical Pathology, Stanford University, CA, USA.; BACKGROUND: Pegylated liposomal doxorubicin (PL-DOX) has been shown in preclinical models to induce less cardiotoxicity than non-liposomal doxorubicin. Endomyocardial biopsy is a highly sensitive and specific method for detecting anthracycline-induced cardiac damage. PATIENTS AND METHODS: Myocardial tissue from ten KS
Increased frequency of CD8 positive gamma/delta T-lymphocytes (CD8+ gamma/delta+) in unmedicated schizophrenic patients: relation to impairment of the blood-brain barrier and HLA-DPA*02011 [letter]: Schizophr Res. 1998 Jun 22;32(1):69-71. Unique Identifier : AIDSLINE MED/98354794; Muller N; Schlesinger BC; Hadjamu M; Riedel M; Schwarz M; Ackenheil M; Wank R; Gruber R
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4.: Int Immunol. 1998 Aug;10(8):1017-26. Unique Identifier : AIDSLINE MED/98389080; Liu L; Rich BE; Inobe J; Chen W; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, MA 02115, USA.; A number of observations indicate that exposure to IL-4 is essential for the priming of Th2-type effector T cells and that exposure to IL-12 is essential for the priming of Th1-type effector T cells. However, the initial source of IL-4 in the early immune response has not been clearly identified. Dendritic cells (DC)
Analysis of the TCR Vgamma repertoire in healthy donors and HIV-1-infected individuals.: Int Immunol. 1998 Aug;10(8):1067-75. Unique Identifier : AIDSLINE MED/98389085; Wesch D; Hinz T; Kabelitz D; Department of Immunology, Paul-Ehrlich-Institute, Langen,; Germany.; During the course of infection with HIV-1, striking alterations in the subset distribution of peripheral blood gammadelta T cells are observed. While TCR Vdelta2 expression dominates among peripheral blood gammadelta T cells in healthy adults, there is a clear preponderance of Vdelta1 cells in HIV-1-infected persons.
Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process.: Int Immunol. 1998 Aug;10(8):1203-10. Unique Identifier : AIDSLINE MED/98389100; Kametani Y; Goto H; Kobori A; Sato T; Ando K; Hozumi K; Nishimura T; Saito T; Yamamoto T; Habu S; Department of Immunology, Tokai University School of Medicine,; Kanagawa, Japan.; Antigen stimulation via TCR in mature T cells provides rapid induction of tyrosine phosphorylation of intracellular substrates including ZAP-70. To study the potential involvement of tyrosine phosphorylation in CD4+CD8+ [double-positive (DP)] thymocytes in the positive selection process in vivo, we isolated and analyz
The effect of pregnancy on survival in women infected with HIV: a systematic review of the literature and meta-analysis.: Br J Obstet Gynaecol. 1998 Aug;105(8):827-35. Unique Identifier : AIDSLINE MED/98417456; French R; Brocklehurst P; Department of Sexually Transmitted Diseases, The Mortimer Market; Centre, London, UK.; OBJECTIVE: To investigate the effect of pregnancy on disease progression and survival in women infected with HIV by a systematic review of the literature and meta-analysis. METHODS: Appropriate publications were identified using electronic and hand searching of relevant journals from 1983 to 1996. Studies were include
The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis.: Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. Unique Identifier : AIDSLINE MED/98417457; Brocklehurst P; French R; National Perinatal Epidemiology Unit, Radcliffe Infirmary,; Oxford, UK.; OBJECTIVE: To investigate the association between maternal HIV infection and perinatal outcome by a systematic review of the literature and meta-analysis. METHODS: Appropriate publications were identified using electronic and hand searching of relevant journals from 1983 to 1996. Studies were included in the review if
Women's knowledge and attitudes, and the acceptability of voluntary antenatal HIV testing.: Br J Obstet Gynaecol. 1998 Aug;105(8):849-54. Unique Identifier : AIDSLINE MED/98417458; Duffy TA; Wolfe CD; Varden C; Kennedy J; Chrystie IL; Women's Services, Guy's and St Thomas' Hospitals Trust, London,; UK.; OBJECTIVE: To assess pregnant women s knowledge of, and attitudes towards, antenatal HIV testing, and its acceptability to them. SETTING: Antenatal clinic at Guy s Hospital, London, six community antenatal clinics and a midwifery group practice. POPULATION: Eight hundred and forty-three women attending the antenatal c
The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability.: Biochemistry. 1998 Sep 29;37(39):13710-9. Unique Identifier : AIDSLINE MED/98426068; Gonzalez ME; Carrasco L; Centro de Biologia Molecular CSIC-UAM, Universidad Autonoma de; Madrid, Cantoblanco, Spain. megonzalez@cbm.uam.es; Infection of T lymphocytes by the human immunodeficiency virus causes drastic alterations in the intracellular cation content of the infected cells. The human immunodeficiency virus type 1 genome encodes several accessory proteins, including Vpu, an integral membrane protein that forms ion channels in planar lipid bil
Effects of secondary structure on DNA and RNA cleavage by diplatinum(II).: Biochemistry. 1998 Sep 29;37(39):13736-43. Unique Identifier : AIDSLINE MED/98426071; Carter PJ; Breiner KM; Thorp HH; Department of Chemistry, University of North Carolina, Chapel; Hill 27599-3290, USA.; The photochemistry of Pt2(pop)44- with nucleic acids has been studied using radiolabeled oligomers of DNA and RNA and high-resolution electrophoresis (pop is P2O5H22-). Photolysis of Pt2(pop)44- with duplex DNA produces an even cleavage ladder and relatively little enhancement of cleavage upon treatment with piperidin
Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR).: Biochemistry. 1998 Sep 29;37(39):13816-26. Unique Identifier : AIDSLINE MED/98426080; Wu S; Kumar KU; Kaufman RJ; The Howard Hughes Medical Institute, Department of Biological; Chemistry, University of Michigan Medical Center, Ann Arbor; 48109, USA.; The interferon-inducible, double-stranded (ds) RNA-dependent protein kinase (PKR) regulates protein synthesis initiation by phosphorylating the alpha-subunit of eukaryotic translation initiation factor 2 (eIF-2). The amino-terminal half of PKR contains two dsRNA binding domains, and the kinase domain resides in the ca
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.: Biochemistry. 1998 Sep 29;37(39):13835-45. Unique Identifier : AIDSLINE MED/98426082; Ridky TW; Kikonyogo A; Leis J; Gulnik S; Copeland T; Erickson J; Wlodawer A; Kurinov I; Harrison RW; Weber IT; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; A series of mutations, first identified in protease inhibitor-resistant HIV-1 viral isolates, were introduced into HIV-1 PR as individual substitutions. Mutants containing R8K, V32I, V82T, I84V, G48V/L90M, or V82T/I84V substitutions were analyzed for differences in substrate preference and catalytic efficiency using a
The dimerization domain of potato spindle tuber viroid, a possible hallmark for infectious RNA.: Biochemistry. 1998 Oct 6;37(40):14098-107. Unique Identifier : AIDSLINE MED/98434382; Gast FU; Kempe D; Sanger HL; Institut fur Biochemie, Justus-Liebig-Universitat Giessen,; Germany. Frank-Ulrich.Gast@chemie.bio.uni-giessen.de; Covalently closed circular (+) RNA of the potato spindle tuber viroid (PSTVd) can efficiently dimerize noncovalently upon heating and slow cooling in the presence of monovalent cations or Mg2+. In vitro transcription of subgenomic fragments reveals that the ability to dimerize resides in the upper strand of its self
Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance.: Biochemistry. 1998 Oct 6;37(40):14189-94. Unique Identifier : AIDSLINE MED/98434393; Vaccaro JA; Anderson KS; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06520-8066, USA.; There is a lack of correlation between biochemical studies and the observed clinical resistance of AIDS patients on long-term AZT therapy. Mutant HIV-1 reverse transcriptase in the viral isolates from these patients shows a 100-fold decrease in sensit
Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules.: Biochemistry. 1998 Oct 6;37(40):14204-12. Unique Identifier : AIDSLINE MED/98434395; Mei HY; Cui M; Heldsinger A; Lemrow SM; Loo JA; Sannes-Lowery KA; Sharmeen L; Czarnik AW; Department of Chemistry, Parke-Davis Pharmaceutical Research,; Division of Warner-Lambert Company, Ann Arbor, Michigan 48106,; USA. Houng-Yau.Mei@wl.com; TAR RNA represents an attractive target for the intervention of human immunodeficiency virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule inhibitors of the HIV-1 Tat-TAR interaction that target the RNA, not the protein. The chemical structures and RNA binding characteristics of t
Actinomycin D inhibition of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase and nucleocapsid protein.: Biochemistry. 1998 Oct 6;37(40):14213-21. Unique Identifier : AIDSLINE MED/98434396; Davis WR; Gabbara S; Hupe D; Peliska JA; Department of Biological Chemistry, University of Michigan; Medical School, Ann Arbor 48109-0606, USA.; Actinomycin D was found to be a potent inhibitor of HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions. Using an oligonucleotide model system, actinomycin D inhibition of DNA strand transfer was examined to elucidate the mechanism of inhibition and further define the mechanism of DNA strand transfer.
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.: Biochemistry. 1998 Oct 13;37(41):14394-403. Unique Identifier : AIDSLINE PDB/R1RT4SF; Ren J; Esnouf RM; Hopkins AL; Warren J; Balzarini J; Stuart DI; Stammers DK; Laboratory of Molecular Biophysics, Oxford, UK.; The carboxanilides are nonnucleoside inhibitors (NNIs) of HIV-1 reverse transcriptase (RT), of potential clinical importance. The compounds differ in potency and in their retention of potency in the face of drug resistance mutations. Whereas UC-84, the prototype compound, only weakly inhibits many RTs bearing single p
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.: Biochemistry. 1998 Oct 20;37(42):14683-91. Unique Identifier : AIDSLINE PDB/0000; Arold S; O'Brien R; Franken P; Strub MP; Hoh F; Dumas C; Ladbury JE; Centre de Biochimie Structurale, UMR C9955 CNRS, U414 INSERM,; Universite Montpellier 1, France.; Understanding the issue of specificity imposed in the interactions of SH3 domains has largely been addressed in studies investigating the interaction of proline-rich amino acid sequences derived from potential ligands for these domains. Although the interaction with this motif forms an essential platform in the bindin
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.: Biochemistry. 1998 Oct 27;37(43):15042-9. Unique Identifier : AIDSLINE MED/99007120; Ala PJ; Huston EE; Klabe RM; Jadhav PK; Lam PY; Chang CH; Experimental Station, DuPont Pharmaceuticals, Wilmington,; Delaware 19880, USA.; The long-term therapeutic benefit of HIV antiretroviral therapy is still threatened by drug-resistant variants. Mutations in the S1 subsite of the protease are the primary cause for the loss of sensitivity toward many HIV protease inhibitors , including our first-gen
A polyethylene glycol copolymer for carrying and releasing multiple copies of cysteine-containing peptides.: Bioconjug Chem. 1998 Sep-Oct;9(5):612-7. Unique Identifier : AIDSLINE MED/98407922; Huang SY; Pooyan S; Wang J; Choudhury I; Leibowitz MJ; Stein S; Center for Advanced Biotechnology and Medicine and Chemistry; Department, Rutgers University, New Brunswick, New Jersey; 08903-2101, USA.; Two different methods were developed to prepare an adduct of a poly(ethylene glycol)-lysine copolymer with either cysteamine or 1-amino-2-methyl-2-propanethiol. Cysteine-containing peptides could then be disulfide-linked to the thiol groups on the polymer in a facile manner. In the described procedures, a coupling rat
[Disseminated histoplasmosis in AIDS patients. A study of 2 cases and review of the Spanish literature]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):316-21. Unique Identifier : AIDSLINE MED/99026409; Benito N; Garcia Vazquez E; Blanco A; de Gorgolas M; Gadea I; Escalonilla P; Fernandez Guerrero ML; Division de Enfermedades Infecciosas, (Servicio de Medicina; Interna), Fundacion Jimenez Diaz, Universidad Autonoma de; Madrid.; The characteristics of two cases of histoplasmosis in AIDS patients in our institution are presented together with a review of the 11 cases published in Spain since 1988 in addition to the current knowledge on histoplasmosis in patients with human immunodeficiency virus infection (H
[Infection by Pseudomonas aeruginosa in patients with human immunodeficiency virus infection. Descriptive study of 35 cases]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):322-7. Unique Identifier : AIDSLINE MED/99026410; Elvira J; Lopez-Suarez A; Clavo A; Pina JM; Segura E; Perez-Guzman E; Giron JA; Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta; del Mar, Cadiz.; OBJECTIVE: Analysis of the spectrum of diseases attributed to Pseudomonas aeruginosa in patients with coinfection with the immunodeficiency virus (HIV). METHODS: Retrospective study of 35 cases of coinfection with P. aeruginosa-HIV, attended from 1985 until 1995. Analysis of putative factors implicated in mortality se
[Fibrin-ring granulomas in an AIDS patient and disseminated infection by Mycobacterium avium-intracellulare (letter)]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):343-4. Unique Identifier : AIDSLINE MED/99026415; Payeras A; Torres JJ; Andreu H; Bassa A; Bosch MA; Buades J
Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy.: Hum Gene Ther. 1998 Jul 20;9(11):1627-42. Unique Identifier : AIDSLINE MED/98357534; Marasco WA; Chen S; Richardson JH; Ramstedt U; Jones SD; Department of Cancer Immunology & AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, MA 02115, USA.
Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen.: Hum Gene Ther. 1998 Aug 10;9(12):1719-29. Unique Identifier : AIDSLINE MED/98386036; Sallberg M; Hughes J; Javadian A; Ronlov G; Hultgren C; Townsend K; Anderson CG; O'Dea J; Alfonso J; Eason R; Murthy KK; Jolly DJ; Chang SM; Mento SJ; Milich D; Lee WT; Chiron Technologies Center for Gene Therapy, San Diego, CA; 92121-1204, USA.; Cytotoxic T lymphocyte (CTL) activity and CD4+ helper T cell responses to the hepatitis B virus (HBV) core antigen (HBcAg) have been implicated in clearance of acute and chronic HBV infections. We showed that intramuscular injections of a novel recombinant retroviral vector expressing an HBcAg-neomycin phosphotransfer
DNA vaccination for leishmaniasis [comment]: Hum Gene Ther. 1998 Sep 1;9(13):1849-50. Unique Identifier : AIDSLINE MED/98412454; Paillard F
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.: Hum Gene Ther. 1998 Sep 1;9(13):1885-98. Unique Identifier : AIDSLINE MED/98412458; Harrod KS; Hermiston TW; Trapnell BC; Wold WS; Whitsett JA; Division of Pulmonary Biology, Children's Hospital Medical; Center, Cincinnati, OH 45229, USA.; Herein, we report that the adenovirus E3-14.7K protein inhibits the inflammatory response to adenovirus in transgenic mice in which the E3-14.7K gene was selectively expressed in the respiratory epithelium, using the human surfactant protein C (SP-C) promoter. E3-14.7K mRNA and protein were detected specifically in th
Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis [see comments]: Hum Gene Ther. 1998 Sep 1;9(13):1899-907. Unique Identifier : AIDSLINE MED/98412459; Walker PS; Scharton-Kersten T; Rowton ED; Hengge U; Bouloc A; Udey MC; Vogel JC; Dermatology Branch, NCI, National Institutes of Health, Bethesda,; MD 20892, USA.; Genetic immunization is a promising gene therapy approach for the prevention and treatment of infectious disease. Plasmid DNA expressing genes of pathogens is directly introduced into host cells and specific cell-mediated and/or humoral immune responses are elicited against the encoded protein. Leishmaniasis is a sign
Photo quiz. Chronic cutaneous verrucous varicella-zoster infection.: Clin Infect Dis. 1998 Aug;27(2):259, 380-1. Unique Identifier : AIDSLINE MED/98375638; Berger AA; Anekthananon T; Bonnez W; Evans T; Department of Medicine, University of Rochester Medical Center,; New York, USA.
Herpes simplex virus infections of the central nervous system in human immunodeficiency virus-infected patients: clinical management by polymerase chain reaction assay of cerebrospinal fluid.: Clin Infect Dis. 1998 Aug;27(2):303-9. Unique Identifier : AIDSLINE MED/98375645; Cinque P; Vago L; Marenzi R; Giudici B; Weber T; Corradini R; Ceresa D; Lazzarin A; Linde A; Department of Infectious Diseases, Scientific Institute San; Raffaele, Milan, Italy.; A duplex polymerase chain reaction (PCR) assay for DNA from herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) was applied to cerebrospinal fluid (CSF) from 918 human immunodeficiency virus (HIV)-infected patients with neurological symptoms. HSV-1 or HSV-2 (HSV-1/2) DNA was found in 19 patients (2%). For the 258 patie
Cytomegalovirus polyradiculopathy in patients with AIDS.: Clin Infect Dis. 1998 Aug;27(2):345-52. Unique Identifier : AIDSLINE MED/98375650; Anders HJ; Goebel FD; Medizinische Poliklinik, Ludwig-Maximilian University, Munich,; Germany.; Using the MEDLINE database, we evaluated 103 cases of AIDS-related cytomegalovirus ( CMV ) polyradiculopathy (PRP). In 13% of cases, PRP was the initial manifestation of AIDS. Hyporeflexia was present in 100% of cases; lower li
Report of invasive Rhodococcus equi infections in Taiwan, with an emphasis on the emergence of multidrug-resistant strains.: Clin Infect Dis. 1998 Aug;27(2):370-5. Unique Identifier : AIDSLINE MED/98375654; Hsueh PR; Hung CC; Teng LJ; Yu MC; Chen YC; Wang HK; Luh KT; Department of Laboratory Medicine, National Taiwan University; Hospital, Taipei, Taiwan.; From November 1995 to October 1997, seven patients with invasive infections due to Rhodococcus equi were treated in Taiwan . Four patients had pulmonary lesions, and one each of the remaining three patients had a recurrent Port-A-Cat
Detection of Enterocytozoon bieneusi in two human immunodeficiency virus-negative patients with chronic diarrhea by polymerase chain reaction in duodenal biopsy specimens and review.: Clin Infect Dis. 1998 Aug;27(2):394-8. Unique Identifier : AIDSLINE MED/98375660; Gainzarain JC; Canut A; Lozano M; Labora A; Carreras F; Fenoy S; Navajas R; Pieniazek NJ; da Silva AJ; del Aguila C; Servicio de Medicina Interna, Hospital Santiago Apostol,; Vitoria, Spain.; Intestinal microsporidiosis has been associated traditionally with severely immunocompromised patients with AIDS. We describe two new cases of intestinal microsporidiosis due to Enterocytozoon bieneusi in human immunodeficiency virus-negative adults. Both patients pres
An open-label pilot study of the efficacy and tolerability of once-daily didanosine versus twice-daily didanosine.: Clin Infect Dis. 1998 Aug;27(2):400-1. Unique Identifier : AIDSLINE MED/98375662; Keiser P; Turner D; Ramilo O; Kvanli MB; Smith JW; Nassar N; University of Texas Southwestern Medical Center at Dallas, USA.
Clinical problems posed by multiresistant nonfermenting gram-negative pathogens.: Clin Infect Dis. 1998 Aug;27 Suppl 1:S117-24. Unique Identifier : AIDSLINE MED/98376539; Quinn JP; Department of Medicine, University of Illinois at Chicago,; College of Medicine, USA.; In this review I will briefly survey the role of Pseudomonas aeruginosa, Acinetobacter baumanii, Stenotrophomonas maltophilia, and Burkholderia cepacia as opportunistic pathogens. A common feature of these organisms is intrinsic resistance to multiple antibiotics. All of these organisms can be recovered from the envir
[Discriminative value for AIDS case of erythrocyte sedimentation rate, immunoglobulins IgA and IgM, and beta 2-microglobulin in combination with the CD4+ lymphocyte count]: An Med Interna. 1998 Aug;15(8):411-4. Unique Identifier : AIDSLINE MED/98453706; Perez de Oteyza C; Menendez Martinez MA; Muro Garcia R; Perez Aznar C; Barberan Lopez J; Departamento de Medicina Interna, Hospital Militar Universitario; Gomez Ulla, Universidad Complutense, Madrid.; OBJECTIVE: To establish the probability to discriminate the evolution to AIDS case in relation to the common laboratory parametres in the follow-up of the HIV infection. MATERIAL AND METHODS: We have studied a cohort of 118 patients (1986-95) with HIV infection, 14 of them (12%) had clinical criteria for AIDS (CDC/9
[Tuberculosis and HIV infection. Clinical characteristics and diagnosis]: An Med Interna. 1998 Aug;15(8):415-20. Unique Identifier : AIDSLINE MED/98453707; Lado Lado FL; Barrio Gomez E; Cabarcos Ortiz de Barron A; Carballo Arceo E; Sanchez Leira J; Perez del Molino ML; Antunez Lopez JR; Servicio de Medicina Interna, Complexo Hospitalario; Universitario, Facultad de Medicina, Santiago de Compostela, La; Coruna.; OBJECTIVE: To analyze the clinical characteristics and diagnose of tuberculosis in patients infected by human immunodeficiency virus in our setting. METHODS: We have revised the clinical, microbiological and histological characteristics of 92 cases diagnosed tuberculosis in seropositive patients, during a span time of
[Which are the vaccines that human immunodeficiency virus infected patients must receive?]: An Med Interna. 1998 Aug;15(8):439-42. Unique Identifier : AIDSLINE MED/98453713; Valencia Ortega ME; Gonzalez Lahoz JM; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; Patients with aids are at increased risk of opportunistic and non opportunistic infections. It is now known that the incidence can be reduced by prophylactic measures and/or the use of vaccines. HIV infection produces an elevated frequency of severe pneumococcal disease with a rate of bacteriemia caused by Streptococc
Construction of a continuous stopping boundary from an alpha spending function.: Biometrics. 1998 Sep;54(3):1061-71. Unique Identifier : AIDSLINE MED/98422646; Betensky RA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA. betensky@sdac.harvard.edu; Lan and DeMets (1983, Biometrika 70, 659-663) proposed a flexible method for monitoring accumulating data that does not require the number and times of analyses to be specified in advance yet maintains an overall Type I error, alpha. Their method amounts to discretizing a preselected continuous boundary by clumping th
Statistical methods for assessing differential vaccine protection against human immunodeficiency virus types.: Biometrics. 1998 Sep;54(3):799-814. Unique Identifier : AIDSLINE MED/98422632; Gilbert PB; Self SG; Ashby MA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) is extremely diverse. In assessing the utility of an HIV-1 vaccine, an important issue is the possibility of differential protection. We discuss statistical methods of inferring how the vaccine efficacy may vary with viral type from data that would be collected from a ra
A semiparametric Bayesian approach to the random effects model.: Biometrics. 1998 Sep;54(3):921-38. Unique Identifier : AIDSLINE MED/98422636; Kleinman KP; Ibrahim JG; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; In longitudinal random effects models, the random effects are typically assumed to have a normal distribution in both Bayesian and classical models. We provide a Bayesian model that allows the random effects to have a nonparametric prior distribution. We propose a Dirichlet process prior for the distribution of the ra
Approaches for optimal sequential decision analysis in clinical trials.: Biometrics. 1998 Sep;54(3):964-75. Unique Identifier : AIDSLINE MED/98422639; Carlin BP; Kadane JB; Gelfand AE; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55455, USA. brad@muskie.biostat.umn.edu; Unlike traditional approaches, Bayesian methods enable formal combination of expert opinion and objective information into interim and final analyses of clinical trial data. However, most previous Bayesian approaches have based the stopping decision on the posterior probability content of one or more regions of the pa
Estimating a treatment effect from multidimensional longitudinal data.: Biometrics. 1998 Sep;54(3):976-88. Unique Identifier : AIDSLINE MED/98422640; Gray SM; Brookmeyer R; Department of Biostatistics, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.; gray@jhu.edu; Multidimensional longitudinal data result when researchers measure an outcome through time that is quantified by many different response variables. These response variables are often defined on different numerical scales. The objective of this paper is to present a method to summarize and estimate an overall treatment
Effects of the ribavirin-interferon alpha combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients.: Cytokine. 1998 Aug;10(8):635-44. Unique Identifier : AIDSLINE MED/98390177; Martin J; Navas S; Quiroga JA; Pardo M; Carreno V; Department of Hepatology, Fundacion Jimenez Diaz, Madrid,; Spain.; The effects of ribavirin and interferon (IFN) alpha have been investigated on cultured peripheral blood mononuclear cells, obtained from 15 patients with chronic hepatitis C virus (HCV) infection. At clinically relevant serum concentrations achieved during therapeutic administration, ribavirin did inhibit moderately t
Fine needle aspiration (FNA) in HIV+ patients [comment]: Cytopathology. 1998 Aug;9(4):219-21. Unique Identifier : AIDSLINE MED/98376550; Buley ID; Department of Cellular Pathology, John Radcliffe Hospital,; Oxford, UK.
Fine needle aspiration (FNA) in HIV+ patients: results from a series of 655 aspirates [see comments]: Cytopathology. 1998 Aug;9(4):222-9. Unique Identifier : AIDSLINE MED/98376551; Ellison E; Lapuerta P; Martin SE; Department of Pathology, University of Southern California, Los; Angeles 90033, USA.; There are many selected small series or case reports of FNAs in patients with HIV infection, but large series are rare and epidemic s characteristics have evolved over time. The current study, from a large public hospital in the USA, included women as well as men, hetero- and homosexuals, in-patients and out-patients,
Diagnostic utility of fine needle aspiration (FNA) cytology in HIV-infected patients with lymphadenopathy [see comments]: Cytopathology. 1998 Aug;9(4):230-9. Unique Identifier : AIDSLINE MED/98376552; Reid AJ; Miller RF; Kocjan GI; Department of Sexually Transmitted Diseases, University College; London Medical School, UK.; Sixty-five FNA cytology procedures were performed on lymph nodes in 52 HIV+ patients. Cervical lymph nodes were the commonest site of FNA cytology investigation (54%). The diagnoses were persistent generalized lymphadenopathy (38%), infection (17%), and malignancy (11%). Diagnosis could not be rendered in 25% of FNA c
Captopril prevents nephropathy in HIV-transgenic mice.: J Am Soc Nephrol. 1998 Aug;9(8):1441-7. Unique Identifier : AIDSLINE MED/98361131; Bird JE; Durham SK; Giancarli MR; Gitlitz PH; Pandya DG; Dambach DM; Mozes MM; Kopp JB; Division of Cardiovascular Drug Discovery, Bristol-Myers Squibb,; Princeton, New Jersey 08543, USA.; Transgenic mice (T26) bearing the envelope, regulatory, and accessory genes of HIV- I develop renal disease resembling human HIV-associated nephropathy (HIVAN). Effects of vehicle (VEH) and the angiotensin-converting enzyme inhibitor captopril (CAP) were examined in wild-type (WT) or T26 mice treated from 7 to 100 d o
Hepatitis viruses under immunosuppressive agents.: J Gastroenterol Hepatol. 1998 Jan;13(1):14-20. Unique Identifier : AIDSLINE MED/98407584; Liaw YF; Liver Research Unit, Chang Gung Memorial Hospital and Medical; College, Taipei, Taiwan.; Clinical and experimental studies have shown that T cell-mediated immune mechanisms are involved in the pathogenesis of hepatitis B virus (HBV) and hepatitis C virus infection. Immunosuppressants may impair T cell function and thereby reduce immune-mediated hepatocytolysis and virus clearance. In addition, corticoster
Diagnostic value of anti-hepatitis D virus (HDV) antibodies revisited: a study of total and IgM anti-HDV compared with detection of HDV-RNA by polymerase chain reaction.: J Gastroenterol Hepatol. 1998 Jan;13(1):57-61. Unique Identifier : AIDSLINE MED/98407591; Huang YH; Wu JC; Sheng WY; Huo TI; Chang FY; Lee SD; Department of Medicine, Veterans General Hospital-Taipei and; National Yang-Ming University School of Medicine, Taiwan,; Republic of China.; A high serum titre (> or = 1000 or > or = 5000) of total antibody to hepatitis D virus (anti-HDV) and positive for immunoglobulin (Ig)M anti-HDV have been used to represent HDV replication, while reverse transcription-polymerase chain reaction (RT-PCR) is currently the most sensitive assay for detecting HDV viraemia.
Prospective follow-up study of hepatitis C virus infection in patients undergoing maintenance haemodialysis: comparison among haemodialysis units.: J Gastroenterol Hepatol. 1998 Jun;13(6):604-9. Unique Identifier : AIDSLINE MED/98381193; Kobayashi M; Tanaka E; Oguchi H; Hora K; Kiyosawa K; Second Department of Internal Medicine, Shinshu University School; of Medicine, Matsumoto, Japan.; A prospective follow-up study on hepatitis C virus (HCV) infection was conducted in seven haemodialysis units from April 1990 to March 1995. A total of 634 patients were undergoing maintenance haemodialysis in the seven units. Of those, 302 patients participated in the follow-up study; 179 were initially HCV antibody
Hepatobiliary tuberculosis.: J Gastroenterol Hepatol. 1998 Aug;13(8):833-9. Unique Identifier : AIDSLINE MED/98405587; Alvarez SZ; Department of Medicine, Faculty of Medicine and Surgery,; University of Santo Tomas, Manila, Philippines.; sza@i-manila.com.ph; Tuberculosis is known to involve the liver in different ways. The term hepatobiliary tuberculosis refers to the localized form of hepatic tuberculosis as a distinct clinical entity, with signs and symptoms related to the hepatobiliary tract. Its clinical features and the different diagnostic aids used in its diagnosis
Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections.: Semin Immunol. 1998 Oct;10(5):383-90. Unique Identifier : AIDSLINE MED/99017922; Biron CA; Department of Molecular Microbiology and Immunology, Division of; Biology and Medicine, Brown University, Providence, RI 02912,; USA.; Innate cytokine responses are important mediators of early defense against infections. Certain of their effects can be delivered directly to activate protective mechanisms in infected cells. Others activate innate immune cells, including natural killer (NK) cells and macrophages, to mediate defense. Still others shape
Bridging the gap: reflections on the 12th World Aids Conference [editorial]: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):17-8. Unique Identifier : AIDSLINE MED/98414892; Sowell R
Revision of HIV center medical staging scale.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):19-23. Unique Identifier : AIDSLINE MED/98414893; McCain NL; Lyon DE; Higginson R; Settle J; Robins JL; Fisher EJ; School of Nursing, Virginia Commonwealth University, Richmond; 23298, USA. nmccain@hsc.vcu.edu; HIV-related symptomatology represents both an indirect measure of immune functioning and a clinically significant indicator of disease progression. The most widely used classification system for HIV-related symptomatology is the Center for Disease Control (CDC) system. Although the CDC scale has widely recognized clin
Improved gastrointestinal tolerance and palatability of didanosine in adults by the use of pediatric power formulation.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):27-31. Unique Identifier : AIDSLINE MED/98414894; Dodge RT; Shipp KW; Miralles GD; Duke University Medical Center, Division of Infectious Diseases,; Durham, North Carolina, USA. robert.dodge@duke.edu; Administration of didanosine (ddI) as buffered tablets is complicated by its poor palatability. The tolerance and palatability of pediatric powder ddI in an adult population of subjects with HIV infection as compared with buffered ddI tablets was compared. Twenty HIV-infected, were enrolled in a randomized crossover t
Triazole therapy for mucocutaneous candidiasis in HIV-infected patients.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):36-44. Unique Identifier : AIDSLINE MED/98414895; Thomas CJ; University of Alabama at Birmingham, Department of Medicine, USA.; Mucocutaneous candidiasis, such as oropharyngeal candidiasis, esophageal candidiasis, and vulvovaginal candidiasis, are common problems in patients with HIV infection. These conditions adversely affect patient quality of life and morbidity status. New oral triazole agents provide improved treatment options for patient
Factors associated with vaginal yeast infections in HIV-positive women.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):47-52. Unique Identifier : AIDSLINE MED/98414896; Williams AB; Andrews S; Tashima K; Mezger J; Yu C; Yale School of Nursing, New Haven, CT 06536-0740, USA.; To better understand factors associated with symptomatic and asymptomatic vulvovaginal candidiasis, including the role of immune compromise and patient self-report, a cross-sectional analysis of factors associated with the isolation of yeast from vaginal swabs and clinical diagnosis of Candida vaginitis (CV) among 184
Nursing practice for HIV/AIDS fever care: a descriptive study.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):53-60. Unique Identifier : AIDSLINE MED/98414897; Jones SG; HIV Critical Pathways Program, Mount Sinai Medial Center, Miami; Beach, Florida, USA.; Nurses often perceive fever in relation to the impact it has on specific patient populations. Fever in HIV/AIDS patients is a common symptom. This descriptive study explored how nurses in AIDS care defined and described fever in HIV/AIDS patients and used nursing interventions for fever management. Seventy-five regist
Practice what we preach? HIV knowledge, beliefs, and behaviors of adolescents and adolescent peer educators.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):61-72. Unique Identifier : AIDSLINE MED/98414898; Villarruel AM; Jemmolt LS; Howard M; Taylor L; Bush E; University of Pennsylvania, School of Nursing, USA.; The purpose of this article is to (a) describe the knowledge, beliefs, and sexual behaviors of urban adolescents and adolescent peer educators, and (b) identify elements needed to design effective HIV/AIDS prevention programs for out-of-school youth. Thirty-three predominantly African American adolescents (female = 14
HIV/AIDS in migrant and seasonal farm workers.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):80-3. Unique Identifier : AIDSLINE MED/98414899; Aranda-Naranjo B; Gaskins S; University of Texas, Health Sciences Center at San Antonio, USA.
Clinicians' antiretroviral medications guide.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):84-6. Unique Identifier : AIDSLINE MED/98414900; Martin JE; Pindaro C; HIV Out-patient Clinic, Medical Center of Louisiana, New Orleans,; USA.
Reviewing the literature.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):87-9. Unique Identifier : AIDSLINE MED/98414901; Sharts-Hopko NC; Villanova University, College of Nursing, USA.
Group sex in gay men: its meaning and HIV prevention implications [letter]: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):90-1. Unique Identifier : AIDSLINE MED/98414902; Simmons P
[Immunoenzyme system for detection of antibodies in their complexes with HIV-1 antigens]: Biull Eksp Biol Med. 1998 Aug;126(8):189-92. Unique Identifier : AIDSLINE MED/98450397; Abelian AV; Shchelkanov MIu; Burunova VV; Kabdulova DO; Karamov EV
Burnout as a clinical entity--its importance in health care workers.: Occup Med (Oxf). 1998 May;48(4):237-50. Unique Identifier : AIDSLINE MED/99016804; Felton JS; Department of Medicine, University of California, Irvine, USA.; Burnout, viewed as the exhaustion of physical or emotional strength as a result of prolonged stress or frustration, was added to the mental health lexicon in the 1970s, and has been detected in a wide variety of health care providers. A study of 600 American workers indicated that burnout resulted in lowered productio
Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses.: Blood. 1998 Oct 15;92(8):2668-71. Unique Identifier : AIDSLINE MED/98438319; Bonecchi R; Sozzani S; Stine JT; Luini W; D'Amico G; Allavena P; Chantry D; Mantovani A; Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.; Macrophage-derived chemokine (MDC) is a CC chemokine that recognizes the CCR4 receptor and is selective for T helper 2 (Th2) versus T helper 1 (Th1) cells. The present study was designed to investigate the effect of the prototypic Th2/Th1 cytokines, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma), on the product
Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected.: Blood. 1998 Oct 15;92(8):2681-7. Unique Identifier : AIDSLINE MED/98438321; Tisdale JF; Stewart AK; Dickstein B; Little RF; Dube I; Cappe D; Dunbar CE; Brown KE; Hematology Branch, National Heart, Lung and Blood Institute,; Bethesda, MD, USA.; Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig et al, Science 276:1851, 1997). We sought to confirm these observation
Flow cytometry in situ polymerase chain reaction as an innovative approach to HIV-1 proviral DNA detection.: Eur J Histochem. 1998;42(2):137-41. Unique Identifier : AIDSLINE MED/98397537; Gibellini D; Zauli G; Re MC; Furlini G; La Placa M; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; In situ polymerase chain reaction represents an intriguing method to couple the sensitivity of PCR technology with the preservation of cell morphology. The target of this technique is the detection of specific DNA or retrotranscribed RNA inside the cell. In this brief report, we describe an in situ polymerase chain re
Viral inactivation of human bone tissue using supercritical fluid extraction.: ASAIO J. 1998 Jul-Aug;44(4):289-93. Unique Identifier : AIDSLINE MED/98346484; Fages J; Poirier B; Barbier Y; Frayssinet P; Joffret ML; Majewski W; Bonel G; Larzul D; Ecole des Mines, Albi, France.; A new bone tissue process using supercritical carbon dioxide fluid extraction (SFE) has been evaluated for its ability to inactivate or eliminate viruses. Four viruses, human immunodeficiency virus type 1 (HIV-1), Sindbis virus, polio Sabin type I virus, and pseudorabies virus (PRV), were exposed to four different pro
Flow cytometry analysis of peripheral blood lymphocytes from patients with bullous pemphigoid.: Dermatology. 1998;197(2):137-40. Unique Identifier : AIDSLINE MED/98402414; Jouen-Beades F; Joly P; Heron F; Paris E; Lauret P; Tron F; Groupe de Recherche en Immunopathologie, Institut Federatif de; Recherche Multidisciplinaire sur les Peptides, Rouen, France.; BACKGROUND: Bullous pemphigoid (BP) is an autoimmune disease observed in elderly subjects in which alteration of peripheral blood lymphocyte subset repartition has been described. OBJECTIVE: To evaluate peripheral blood lymphocyte subsets from BP patients and identify immunologic changes that can be assigned either to
HIV-Associated eosinophilic folliculitis and follicular mucinosis.: Dermatology. 1998;197(2):178-80. Unique Identifier : AIDSLINE MED/98402423; Buezo GF; Fraga J; Abajo P; Rios L; Dauden E; Garcia-Diez A; Department of Dermatology, Hospital Universitario de la Princesa,; Universidad Autonoma, Madrid, Spain.; The term HIV-associated eosinophilic folliculitis (EF) designates an idiopathic dermatitis that appears in HIV-infected patients with different clinical manifestations but with a distinctive histological feature characterized by a predominantly eosinophilic infiltrate in the follicular infundibula. On the other side,
Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1.: Mamm Genome. 1998 Oct;9(10):849-52. Unique Identifier : AIDSLINE GENBANK/AF016898; Meyer NP; Johansen LM; Tae HJ; Budde PP; Williams KL; Taparowsky EJ; Department of Biological Sciences, Purdue University, West; Lafayette, Indiana 47907-1392, USA.
Influence of delayed viral production on viral dynamics in HIV-1 infected patients.: Math Biosci. 1998 Sep;152(2):143-63. Unique Identifier : AIDSLINE MED/98453897; Mittler JE; Sulzer B; Neumann AU; Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National; Laboratory, MS-K710, NM 87545, USA. jmittler@t10.lanl.gov; We present and analyze a model for the interaction of human immunodeficiency virus type 1 (HIV-1) with target cells that includes a time delay between initial infection and the formation of productively infected cells. Assuming that the variation among cells with respect to this intracellular delay can be approximat
Protease inhibitors in antiviral therapy of paediatric HIV disease [letter]: Acta Paediatr. 1998 Jul;87(7):814-6. Unique Identifier : AIDSLINE MED/98387716; Manfredi R; Monari P; Donzelli C; Furlini G; Re MC; Chiodo F
Similar birthweight in children born to HIV-2 infected and HIV-negative women in Guinea-Bissau [letter]: Acta Paediatr. 1998 Jul;87(7):816-7. Unique Identifier : AIDSLINE MED/98387717; Norrgren H; Andersson S; Dias F; Alves A; Naucler A; Biberfeld G
Apathy, depression, and cognitive performance in HIV-1 infection.: J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):320-9. Unique Identifier : AIDSLINE MED/98371829; Castellon SA; Hinkin CH; Wood S; Yarema KT; Department of Psychology, University of California-Los Angeles; 90024, USA. scastell@ucla.edu; The authors examined the relationship between apathy, depression, and cognitive performance in 48 HIV-1-seropositive and 21 seronegative (control) subjects, using reaction time (RT) and working memory tasks. Apathy, but not depression, was associated with working memory deficits among HIV-seropositive subjects. The co
Neurobehavioral correlates of perceived mental and motor slowness in HIV infection and AIDS.: J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):343-50. Unique Identifier : AIDSLINE MED/98371832; Lopez OL; Wess J; Sanchez J; Dew MA; Becker JT; Department of Neurology, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; The authors assessed 72 human immunodeficiency virus (HIV)-infected patients with a self-rating slowness scale (SRSS) concerning mental and motor slowness in their activities of daily living. In order to understand the relationship between complaints of slowness and predictor variables, the investigators developed a p
Expression and purification of HIV-I p15NC protein in Escherichia coli.: Protein Expr Purif. 1998 Oct;14(1):54-64. Unique Identifier : AIDSLINE MED/98432900; Ozturk DH; Erickson-Viitanen S; Virology Department, The DuPont Merck Pharmaceutical Company,; Experimental Station, Building E336/1B, Wilmington, Delaware,; 19880-0336, USA. derya.h.ozturk@dupontpharma.com; An efficient method for the expression and purification of nucleocapsid precursor protein (p15NC) from HIV-I (BH 10 isolate) was developed and used to obtain large quantities of this viral protein for structural studies, protein biochemistry, and high-throughput screening efforts. We have engineered an existing p15NC
Effect of promoters and signal sequences on the production of secreted HIV-1 gp120 protein in the baculovirus system.: Protein Expr Purif. 1998 Oct;14(1):8-12. Unique Identifier : AIDSLINE MED/98432894; Golden A; Austen DA; van Schravendijk MR; Sullivan BJ; Kawasaki ES; Osburne MS; Procept, Inc., 840 Memorial Drive, Cambridge, Massachusetts,; 02139, USA.; We compared insect cell production levels of secreted HIV-1 gp120 glycoprotein encoded by five different baculovirus expression constructs. Combinations consisting of one of two baculovirus promoters (very late or hybrid late/very late) and one of three different signal sequences [human tissue plasminogen activator (t
Hyperthyroidism due to lymphoma involving the thyroid gland in a patient with acquired immunodeficiency syndrome: case report and review of the literature.: Thyroid. 1998 Aug;8(8):673-7. Unique Identifier : AIDSLINE MED/98407380; Samuels MH; Launder T; Division of Endocrinology, Metabolism, and Clinical Nutrition,; Oregon Health Sciences University, Portland 97201, USA.; A 31-year old woman with acquired immunodeficiency syndrome (AIDS) and a history of lymphoma presented with a 2-week history of severe hyperthyroid symptoms and new-onset neck swelling. On physical examination, she was found to be clinically hyperthyroid, with a markedly enlarged, diffuse, tender goiter. Thyroid funct
Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice.: Int Arch Allergy Immunol. 1998 Sep;117 Suppl 1:14-9. Unique Identifier : AIDSLINE MED/98432878; Kasai M; Kumano K; Kurasawa K; Nakao A; Saito Y; Iwamoto I; Department of Internal Medicine II, Chiba University School of; Medicine, Chiba City, Japan.; To determine whether the costimulatory signal via CD28/B7 interaction is required for causing allergic inflammation, we examined the effect of administration of CTLA4-Ig, a fusion protein of the extracellular domain of CTLA4 and human IgG1-constant region, at the time of sensitization, on antigen-induced eosinophil in
The involvement of CD80 and CD86 costimulatory molecules in the induction of eosinophilia in mice infected with Nippostrongylus brasiliensis.: Int Arch Allergy Immunol. 1998 Sep;117 Suppl 1:2-4. Unique Identifier : AIDSLINE MED/98432875; Huang Y; Watanabe N; Ohtomo H; Department of Tropical Medicine, Jikei University School of; Medicine, Tokyo, Japan.; The costimulatory signal provided by the interaction between CD28 and its ligands, CD80 and CD86, is critical for T cell activation. The requirement of CD80 and CD86 in T cell activation for eosinophilia and IgE production was examined in mice infected with the nematode parasite Nippostrongylus brasiliensis. Combined
Infection rates are still rising [letter]: Can Fam Physician. 1998 Sep;44:1800, 1803. Unique Identifier : AIDSLINE MED/99006087; Salmon B
Oral manifestations of human immunodeficiency virus-infected patients in Taiwan.: J Formos Med Assoc. 1998 Sep;97(9):600-5. Unique Identifier : AIDSLINE MED/99011619; Chiang CP; Chueh LH; Lin SK; Chen MY; School of Dentistry, College of Medicine, National Taiwan; University, Taipei, Taiwan.; To understand the characteristic clinical features of human immunodeficiency virus (HIV)-related oral lesions and determine the prevalence of various oral lesions in HIV-infected patients in Taiwan , we conducted a cross-sectional st
Informed consent. Policy has loopholes [letter]: BMJ. 1998 Oct 3;317(7163):949. Unique Identifier : AIDSLINE MED/99023101; Winter AJ; Mullis D; Radcliffe KW
Commission set up to deal with HIV infected doctors in Spain [news]: BMJ. 1998 Oct 10;317(7164):970. Unique Identifier : AIDSLINE MED/99023107; Bosch X
AIDS deaths fall by nearly one half [news]: BMJ. 1998 Oct 17;317(7165):1032. Unique Identifier : AIDSLINE MED/99033882; Gottlieb S
South African AIDS plan criticised [news]: BMJ. 1998 Oct 17;317(7165):1032. Unique Identifier : AIDSLINE MED/99033883; Sidley P
Oral treatment for hepatitis B gets approval in the United States [news]: BMJ. 1998 Oct 17;317(7165):1034. Unique Identifier : AIDSLINE MED/99033884; Josefson D
Factors associated with gonorrhoea in men aware of being positive for HIV infection: case-control study.: BMJ. 1998 Oct 17;317(7165):1052-3. Unique Identifier : AIDSLINE MED/98447548; Sadiq ST; Copas AJ; Johnson AM; Mortimer Market Centre, Camden and Islington Community NHS Trust,; London WC1E 6AU. tsadi@msn.com
Vaginal viricides-another way to tackle HIV transmission.: BMJ. 1998 Oct 17;317(7165):1053. Unique Identifier : AIDSLINE MED/98447549; Berger A
Post-exposure prophylaxis against HIV infection is hard to supply for expatriate staff [letter]: BMJ. 1998 Oct 17;317(7165):1084. Unique Identifier : AIDSLINE MED/98447571; Logie A
Socially desirable response tendency as a correlate of accuracy of self-reported HIV serostatus for HIV seropositive injection drug users.: Addiction. 1998 Aug;93(8):1191-7. Unique Identifier : AIDSLINE MED/99031443; Latkin CA; Vlahov D; Department of Health Policy and Management, Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA. clatkin@ihsph.edu; AIMS: This study examined the accuracy of self-reported HIV serostatus for injection drug users and the predictive validity of a measure of social desirability to detect inaccurate self-reports. DESIGN: Participants in the ALIVE study were provided testing for HIV antibodies and counseling every 6 months. In the separ
Adult T-cell leukemia/lymphoma in London: clinical experience of 21 cases.: Leuk Lymphoma. 1998 Sep;31(1-2):177-85. Unique Identifier : AIDSLINE MED/98385681; Pawson R; Richardson DS; Pagliuca A; Kelsey SM; Hoque S; Breuer J; Newland AC; Mufti GJ; Department of Hematological Medicine, King's College Hospital; School of Medicine and Dentistry, London, UK.; Adult T-cell leukemia/lymphoma (ATLL) is uncommon in the United Kingdom and has so far been restricted to people of Afro-Caribbean extraction. Between 1981 and 1995, 21 cases presented to 2 inner London teaching hospitals where 17% of the population are of Afro-Caribbean origin. Clinic
BCL-6 in aids-related lymphomas: pathogenetic and histogenetic implications.: Leuk Lymphoma. 1998 Sep;31(1-2):39-46. Unique Identifier : AIDSLINE MED/98385667; Gaidano G; Capello D; Gloghini A; Pastore C; Migliazza A; Quattrone S; Savinelli F; Buonaiuto D; Cilia AM; Perin T; Pasqualucci L; Canzonieri V; Saglio G; Dalla-Favera R; Carbone A; Department of Medical Sciences, University of Torino at Novara,; Italy. gaidano@med.no.unipmn.it; AIDS-related non-Hodgkin s lymphomas (AIDS-NHL) are classified into Burkitt s lymphoma, diffuse large cell lymphoma (DLCL), and body cavity based lymphoma. The molecular pathogenesis of AIDS-NHL is complex and involves the genetic alteration of several cancer related genes, including the BCL-6 proto-oncogene. BCL-6 en
HIV-1 reverse transcriptase is capable of elongating derivatives of sequence specific noncomplementary oligodeoxynucleotides.: Biochem Mol Biol Int. 1998 Aug;45(5):857-64. Unique Identifier : AIDSLINE MED/98411766; Martyanov IV; Zakharova OD; Sottofattori E; Maksakova GA; Pyshnyi DV; Mazzei M; Balbi A; Litvak S; Tarrago-Litvak L; Nevinsky GA; Novosibirsk Institute of Bioorganic Chemistry, Siberian Division; of Russian Academy of Sciences, Russia.; We have carried out a comparison of KM and Vmax values for various primers in the polymerization reaction catalyzed by the HIV-1 RT. The affinity of RT for complementary d(pT)6 containing two different 5 -end pyranone derivatives was 2-3 orders of magnitude higher (KM = 3-15 nM) than that of d(pT)6 (KM = 12.6 mM). Oli
Safety aspects of cord blood banking.: Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S40-2. Unique Identifier : AIDSLINE MED/98376337; Warwick RM; Barbara JA; London Cord Blood Bank, National Blood Service, UK.; The safety of cord blood for transplantation depends upon a considered approach to donor selection, testing and processing of donations. It should be undertaken within a total quality system and good manufacturing practice facilities. Protocols should be developed based upon risk assessment and cost efficiency. In thi
A comparative study on the efficacy of CD8-positive cells in enhancing allogeneic bone marrow engraftment: cell sorting vs microbead selection.: Bone Marrow Transplant. 1998 Sep;22(5):477-84. Unique Identifier : AIDSLINE MED/98402107; Sen-Majumdar A; Sheehan K; Guo G; Allegre G; Simone J; Harvey M; Chow P; Moen R; Smith A; Geneic Sciences Inc., Menlo Park, CA, USA.; We have used a superparamagnetic microbead selection system to positively select a murine bone marrow CD8+ cell population. The functional ability of these cells to enhance allogeneic bone marrow engraftment was compared with that of fluorescence activated cell sorter purified CD8+ cells. The CD8+ cell population prep
[Another look at the AIDS virus]: Bull Mem Acad R Med Belg. 1998;153(2):139-43. Unique Identifier : AIDSLINE MED/98433481; Burny A; Universite libre de Bruxelles, Gembloux, Belgique.
Anti-HIV-1 activity of herbs in Labiatae.: Biol Pharm Bull. 1998 Aug;21(8):829-33. Unique Identifier : AIDSLINE MED/98414183; Yamasaki K; Nakano M; Kawahata T; Mori H; Otake T; Ueba N; Oishi I; Inami R; Yamane M; Nakamura M; Murata H; Nakanishi T; Osaka Prefectural Institute of Public Health, Japan.; The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Menth
Epidemiological and clinical patterns of intrathoracic lymph node tuberculosis in 60 human immunodeficiency virus-negative adult patients.: Monaldi Arch Chest Dis. 1998 Jun;53(3):277-80. Unique Identifier : AIDSLINE MED/99001990; Codecasa LR; Besozzi G; De Cristofaro L; Miradoli A; Sabolla L; Tagliaferri B; Lombardy Reference Centre for TB, Villa Marelli Institute for; Chest Disease, Milano, Italy.; We retrospectively evaluated a group of human immunodeficiency virus (HIV)-negative adult patients with hilar and/or mediastinal tubercular adenopathy to assess their epidemiological, clinical and radiological features. Out of 3,003 intrathoracic tuberculosis (TB) cases (of which 745 were immigrants from various devel
The genetics of psoriasis: a complex disorder of the skin and immune system.: Hum Mol Genet. 1998;7(10):1537-45. Unique Identifier : AIDSLINE MED/98407934; Bhalerao J; Bowcock AM; Department of Internal Medicine, Pediatrics and McDermott Center; for Human Growth and Development, University of Texas; Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas,; TX 75235-8591, USA.; In the last few years, molecular genetics analyses have permitted novel insights into psoriasis, a disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T cells into the skin. The disease affects approximately 1-2% of the Caucasian population and can occur in association with other in
Body temperature alterations in hospitalized HIV/AIDS patients.: Medsurg Nurs. 1998 Aug;7(4):217-22. Unique Identifier : AIDSLINE MED/98456221; Jones SG; Holloman F; Coffin D; Mount Sinai Medical Center, Miami Beach, FL, USA.; Because of the questions raised by the staff nurses regarding their observations of fever and alterations in body temperature in AIDS patients, a nursing research study was conducted to examine the incidence and degree of temperature elevation in hospitalized AIDS patients. Study findings suggest that temperature elev
AIDS: a picture of reality.: Medsurg Nurs. 1998 Aug;7(4):223-5. Unique Identifier : AIDSLINE MED/98456222; Turjanica MA; Inova Fairfax Hospital, Falls Church, VA, USA.
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Aug 28;8(35):315-6. Unique Identifier : AIDSLINE MED/98443768
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Sep 25;8(39):351-2. Unique Identifier : AIDSLINE MED/98455966
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Oct 23;8(43):385-8. Unique Identifier : AIDSLINE MED/99022669
Recent advances in pediatric pulmonary imaging.: Curr Opin Pediatr. 1998 Jun;10(3):227-35. Unique Identifier : AIDSLINE MED/98382610; Harty MP; Kramer SS; Department of Radiology, Children's Hospital of Philadelphia, PA; 19104, USA.; Beyond basic screening chest radiographs, modern cross-sectional imaging with computed tomography and magnetic resonance imaging demonstrates more detailed anatomic and pathologic information than previously possible. This information is important if it influences decision-making during patient care and management and
Early effects of a school-based human immunodeficiency virus infection and sexual risk prevention intervention.: Arch Pediatr Adolesc Med. 1998 Oct;152(10):961-70. Unique Identifier : AIDSLINE MED/99005266; Siegel DM; Aten MJ; Roghmann KJ; Enaharo M; Department of Pediatrics, University of Rochester, Rochester; General Hospital, NY 14621, USA. david.siegel@viahealth.org; OBJECTIVE: To determine the short-term effect of a middle and high school-based human immunodeficiency virus and sexuality intervention (Rochester AIDS Prevention Project for Youth [RAPP]) on knowledge, self-efficacy, and behavior intention. DESIGN: Nonrandomized intervention study with 2 intervention groups and 1 con
Factors impacting the delivery of therapeutic levels of pyrone-based HIV protease inhibitors.: Pharm Biotechnol. 1998;11:211-32. Unique Identifier : AIDSLINE MED/98433391; Padbury GE; Zipp GL; Schwende FJ; Zhao Z; Koeplinger KA; Chong KT; Raub TJ; Thaisrivongs S; Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49007, USA.
The integration of medicinal chemistry, drug metabolism, and pharmaceutical research and development in drug discovery and development. The story of Crixivan, an HIV protease inhibitor.: Pharm Biotechnol. 1998;11:233-55. Unique Identifier : AIDSLINE MED/98433392; Lin JH; Ostovic D; Vacca JP; Drug Metabolism, Merck Research Laboratories, West Point,; Pennsylvania 19486, USA.
De novo design and discovery of cyclic HIV protease inhibitors capable of displacing the active-site structural water molecule.: Pharm Biotechnol. 1998;11:257-84. Unique Identifier : AIDSLINE MED/98433393; De Lucca GV; Jadhav PK; Waltermire RE; Aungst BJ; Erickson-Viitanen S; Lam PY; DuPont Merck Pharmaceutical Company, Wilmington, Delaware; 19880-0500, USA.
Discovery and development of the BHAP nonnucleoside reverse transcriptase inhibitor delavirdine mesylate.: Pharm Biotechnol. 1998;11:285-312. Unique Identifier : AIDSLINE MED/98433394; Adams WJ; Aristoff PA; Jensen RK; Morozowich W; Romero DL; Schinzer WC; Tarpley WG; Thomas RC; Discovery Chemistry, Pharmacia & Upjohn, Inc., Kalamazoo,; Michigan 49001-0199, USA.
AIDS-related primary pulmonary lymphoma.: Am J Respir Crit Care Med. 1998 Oct;158(4):1221-9. Unique Identifier : AIDSLINE MED/98443320; Ray P; Antoine M; Mary-Krause M; Lebrette MG; Wislez M; Duvivier C; Meyohas MC; Girard PM; Mayaud C; Cadranel J; Services de Pneumologie et de Reanimation Respiratoire et; Service d'Anatomie-Pathologique, Hopital Tenon, 4 rue de la; Chine, 75020 Paris, France.; We describe 12 cases of AIDS-related primary pulmonary lymphoma occurring between 1986 and 1996 in a large French cohort of HIV-infected patients. Diagnostic criteria were: (1) histologically proven lymphomatous pulmonary involvement; (2) absence of mediastinal and/or hilar adenopathy on chest radiography; (3) absence
[Renal complications associated with human acquired immunodeficiency virus infection in a population of hospital patients at the Hospital and University National Center in Cotonou]: Sante. 1998 Jul-Aug;8(4):283-6. Unique Identifier : AIDSLINE MED/99010454; Attolou V; Bigot A; Ayivi B; Gninafon M; Service de nephrologie, hopital Bretonneau, Tours.; We studied 92 HIV-positive patients retrospectively between January 1994 and December 1996 and prospectively from January to July 1997. We determined serum creatinine and 24-hour proteinuria. The median age of the patients was 22 (+/- 4) years and most patients were aged between 25 and 45 years. The sex ratio was 2.17
[Management of AIDS during traditional hospitalization and at outpatient clinics in Recife (Brazil)]: Sante. 1998 Jul-Aug;8(4):315-7. Unique Identifier : AIDSLINE MED/99010461; Hinrichsen SL; Sobral S; Reis L; Assuncao R; Santiago J; Araujo C; Moraes E; Vieira SM; Vieira DS; Torres V; Gazin P; Service des maladies infectieuses et parasitaires (NEPAI),; Hospital das Clinicas, Universite federale du Pernambouc; (UFPE), Recife, Bresil.; The management of 50 AIDS patients by traditional hospital admission (25 cases) and outpatient clinics (25 cases) was studied between August and November 1995 in the Department of Infectious and Parasitic Diseases of the Federal University Hospital. The most costly items of expenditure were hospital services and consu
Infection control in the age of AIDS: the dental assistant's role.: Dent Assist. 1993 3rd Quarter;62(3):7-11. Unique Identifier : AIDSLINE MED/99006449; Moreland N; Network Management for First Commonwealth, Inc., Chicago,; Illinois, USA.
Evaluating the process of tailoring the global HIV/AIDS practice guidelines for use in developing countries.: Int J Qual Health Care. 1998 Apr;10(2):147-54. Unique Identifier : AIDSLINE MED/98353198; Wabitsch R; Margolis CZ; Malkin JE; Abu-Saad K; Waksman J; Joint Medical Service, United Nations Secretariat, Geneva,; Switzerland.; OBJECTIVE: To describe a systematic procedure for adapting, or tailoring the World Health Organisation s global guidelines for the management of HIV/AIDS in adults and children for use in two developing countries: Malawi and Barbados . DESI
Diphtheria toxin A gene-mediated HIV-1 protection of cord blood-derived T cells in the SCID-hu mouse model.: J Hematother. 1998 Aug;7(4):319-31. Unique Identifier : AIDSLINE MED/98405270; Banda NK; Akkina RK; Terrell K; Shpall EJ; Tomczak J; Campain J; Claman H; Cagle L; Harrison GS; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA.; The reconstitutive potential of CD34+-derived cord blood (CB) cells, transduced with a regulated diphtheria toxin A (DT-A) chain gene, was examined in SCID-hu mice harboring a conjoint organ composed of human thymus and liver (thy/liv). The DT-A-transduced cells, injected directly into the thy/liv organ, showed the sa
Phase-II randomized study of pre-operative IL-2 administration in operable NSCLC.: Lung Cancer. 1998 Jun;20(3):191-202. Unique Identifier : AIDSLINE MED/98401890; Masotti A; Morandini G; Ortolani R; Fumagalli L; Division of Pneumology, Az. Osp. Istituti Ospitalieri di Verona,; Ospedale Civile Maggiore, Italy.; Lymphocytopenia is a prognostic factor for shorter survival in advanced lung cancer and it is likely related to an interleukin-2 ( IL-2 ) deficiency occurring during cancer progression. Major surgery itself for cancer is known to induce lymphocytopenia in the postoperati
Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection.: Bioorg Med Chem. 1998 Jul;6(7):1033-41. Unique Identifier : AIDSLINE MED/98397989; Tamamura H; Imai M; Ishihara T; Masuda M; Funakoshi H; Oyake H; Murakami T; Arakaki R; Nakashima H; Otaka A; Ibuka T; Waki M; Matsumoto A; Yamamoto N; Fujii N; Graduate School of Pharmaceutical Sciences, Kyoto University,; Japan. tamamura@pharm.kyoto-u.ac.jp; We have previously found that T22 ([Tyr(5,12), Lys7]-polyphemusin II) has strong anti-human immunodeficiency virus (HIV) activity, and that T22 inhibits T cell-line-tropic HIV-1 infection mediated by CXCR4/fusin. T22 is an 18-residue peptide amide, which takes an antiparallel beta-sheet structure that is maintained by
Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):203-9. Unique Identifier : AIDSLINE MED/99019106; Washington CB; Duran GE; Man MC; Sikic BI; Blaschke TF; Department of Medicine, Stanford University Medical Center,; California 94305-5130, USA.; The anti-HIV protease inhibitors represent a new class of agents for treatment of HIV infection. Saquinavir, ritonavir , indinavir ,
Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):210-20. Unique Identifier : AIDSLINE MED/99019107; Brice GT; Riley JL; Villinger F; Mayne A; Hillyer CD; June CH; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, Georgia 30322, USA.; Previous studies have shown that in vitro culture of human CD4+ T cells with antibodies to CD3 and CD28 immobilized on beads induced an antiviral effect to HIV-1 infection. Herein, we have used CD4+ T cells from nonhuman primates to address issues critical for use of such cells for therapy and immune reconstitution of
HIV-1-induced perturbations of glycosphingolipid metabolism are cell-specific and can be detected at early stages of HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):221-9. Unique Identifier : AIDSLINE MED/99019108; Fantini J; Tamalet C; Hammache D; Tourres C; Duclos N; Yahi N; Laboratoire de Biochimie et Biologie de la Nutrition, Faculte; des Sciences de St Jerome, Marseille, France.; JACQUES.FANTINI@LBBN.u-3mrs.fr; The metabolism of glycosphingolipids (GSL) has been investigated in peripheral blood mononuclear cells (PBMC) from 8 patients at an early stage of HIV-1 infection. Following metabolic labeling of these cells with [14C]galactose, the GSL were purified and the radioactivity incorporated into each individual GSL quantita
Analysis of HIV-1 reverse transcriptase gene mutations in infected children treated with zidovudine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):230-7. Unique Identifier : AIDSLINE MED/99019109; Orlandi P; Cancrini C; Scaccia S; Romiti ML; Livadiotti S; Gattinara GC; Angelini F; Cox S; Rossi P; Division of Immunology and Infectious Diseases, Children's; Hospital Bambino Gesu, University of Rome Tor Vergata, Italy.; Prolonged treatment with antiretroviral agents directed against reverse transcription (RT) in patients with HIV-1 infection results in the emergence of virus variants with reduced sensitivity containing mutations in the HIV-1 RT gene. Development of zidovudine (ZDV)-related mutations was studied in a cohort of 24 vert
Correlation among total lymphocyte count, absolute CD4+ count, and CD4+ percentage in a group of HIV-1-infected South African patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):238-44. Unique Identifier : AIDSLINE MED/99019110; van der Ryst E; Kotze M; Joubert G; Steyn M; Pieters H; van der Westhuizen M; van Staden M; Venter C; Department of Virology, University of the Orange Free State,; Bloemfontein, South Africa. gnvrevdr@med.uovs.ac.za; Depletion of CD4+ T cells is one of the hallmarks of progression of HIV-1 infection. However, measurement of the CD4+ T-cell count is expensive and often unavailable in less developed areas. Previous studies have suggested that the total lymphocyte count (TLC) can be used to predict a low absolute CD4+ T-cell count. T
Body mass index course in asymptomatic HIV-infected homosexual men and the predictive value of a decrease of body mass index for progression to AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):254-9. Unique Identifier : AIDSLINE MED/99019112; Maas JJ; Dukers N; Krol A; van Ameijden EJ; van Leeuwen R; Roos MT; de Wolf F; Coutinho RA; Keet IP; Municipal Health Service, Department of Public Health and; Environment, Amsterdam, The Netherlands.; Weight loss is a common characteristic of advanced stages of HIV infection. Weight changes during the asymptomatic stage of HIV infection have not been well documented and the possible predictive value of early weight loss for progression to AIDS is unknown. In 122 HIV seroconverters, the natural course of body mass i
High prevalence of insomnia in an outpatient population with HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):260-5. Unique Identifier : AIDSLINE MED/99019113; Rubinstein ML; Selwyn PA; AIDS Program, Yale School of Medicine, New Haven, Connecticut; 06510, USA.; OBJECTIVE: To determine the prevalence, characteristics, and clinical recognition of insomnia in HIV-seropositive outpatients. DESIGN: Systematic sample of patients attending an outpatient HIV/AIDS clinic at an urban teaching hospital. METHODS: Patients were recruited for standard interviews including Pittsburgh Sleep
Geographic differences in noninjection and injection substance use among HIV-seropositive men who have sex with men: western United States versus other regions. Supplement to HIV/AIDS Surveillance Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):266-73. Unique Identifier : AIDSLINE MED/99019114; Sullivan PS; Nakashima AK; Purcell DW; Ward JW; Division of HIV/AIDS Prevention--Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Atlanta,; Georgia, USA.; To study the prevalence of and factors associated with the use of alcohol and nonprescription drugs by HIV-seropositive men who have sex with men (MSM) and to describe variations in alcohol and nonprescription drug use by geographic region, we analyzed data from a multistate, population- and facility-based interview s
Temporal trends in HIV risk behaviors of out-of-treatment injection drug users and injection drug users who smoke crack.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):274-81. Unique Identifier : AIDSLINE MED/99019115; Semaan S; Kotranski L; Collier K; Lauby J; Halbert J; Feighan K; Philadelphia Health Management Corporation, Pennsylvania 19102,; USA.; This study compared the baseline sociodemographic characteristics and HIV risk behaviors of two groups of out-of-treatment injection drug users (IDUs): 366 who concurrently smoked crack (smoking IDUs) and 212 who did not smoke crack (IDUs) in the past 30 days. Temporal trends in recent risk behaviors were also assesse
HIV seropositivity rates in outreach-based counseling and testing services: program evaluation.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):282-8. Unique Identifier : AIDSLINE MED/99019116; DiFranceisco W; Holtgrave DR; Hoxie N; Reiser WJ; Resenhoeft R; Pinkerton SD; Vergeront J; Cost-Effectiveness Studies Core, Center for AIDS Intervention; Research, Medical College of Wisconsin, Milwaukee 53226, USA.; wayned@mcw.edu; A common assumption is that outreach-based HIV counseling and testing services reach a clientele with a higher HIV seroprevalence than clinic-based counseling and testing. To examine this assumption, we analyzed Wisconsin s anonymous counseling and testing client records for 62,299 contacts (testing episodes) from 199
Infection with HIV-1 subtypes B and E in injecting drug users screened for enrollment into a prospective cohort in Bangkok, Thailand.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):289-95. Unique Identifier : AIDSLINE MED/99019117; Kitayaporn D; Vanichseni S; Mastro TD; Raktham S; Vaniyapongs T; Des Jarlais DC; Wasi C; Young NL; Sujarita S; Heyward WL; Esparza J; HIV/AIDS Collaboration, Nonthaburi, Thailand.; From May through August 1995, a cross-sectional survey was conducted among injecting drug users (IDUs) drawn from 15 drug treatment clinics in Bangkok and who were not known to be HIV-seropositive, to determine the prevalence of HIV-1 subtypes B and E and related risk behaviors, and to offer enrollment in a prospectiv
HIV prevalence in pregnant women in Europe: differences in assessment methods and prevalence levels across countries.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):296-305. Unique Identifier : AIDSLINE MED/99019118; Cazein F; Hamers FF; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.; OBJECTIVE: To describe methods used to assess HIV prevalence and to assess prevalence levels and time trends among pregnant women in various European countries. METHODS: We used the European HIV Prevalence Database to examine annual HIV prevalence data in pregnant women for the years 1990 to 1996 (20 countries). RESUL
Combination antiretroviral therapy including a protease inhibitor eliminated the transfusion requirements of HIV-infected individuals with anemia of chronic disease [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):306-7. Unique Identifier : AIDSLINE MED/99019119; Mylonakis E; Dickinson B; Feller A; Sweeney J; Schiffman FJ; Rich J; Flanigan T
Body shape changes in HIV-infected patients [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):307-8. Unique Identifier : AIDSLINE MED/99019120; Lo JC; Mulligan K; Tai VW; Algren H; Schambelan M
Introduction of HIV-1 subtype A in the French West Indies [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):308-10. Unique Identifier : AIDSLINE MED/99019121; Ouka M; Menu E; Barin F; Bera O; Muller-Trutwin MC; Cales-Quist D; Comlan-Mayaud G; Abel S; Martial J; Neisson-Vernant C; Sobesky G; Barre-Sinoussi F; Cesaire R
Molecular and epidemiologic evidence for the discontinuous introduction of subtypes B and F into Rio de Janeiro, Brazil [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):310-2. Unique Identifier : AIDSLINE MED/99019122; Pinto ME; Tanuri A; Schechter M
Virtues of being faithful: can we limit the genetic variation in human immunodeficiency virus?: J Mol Med. 1998 Aug;76(9):604-12. Unique Identifier : AIDSLINE MED/98391601; Drosopoulos WC; Rezende LF; Wainberg MA; Prasad VR; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, NY 10461, USA.; Human immunodeficiency virus (HIV) infections are characterized by a high degree of viral variation. The genetic variation is thought to be a combined effect of a high error rate of reverse transcriptase (RT), viral genomic recombination, the selection forces of the human immune system, the requirement for growth in m
[Factors predictive of early virologic response after a first treatment with an protease inhibitor in the course of HIV infection]: Bull Acad Natl Med. 1998;182(5):981-92; discussion 992-5. Unique Identifier : AIDSLINE MED/98406463; Frottier J; Meynard JL; Morand-Joubert L; Guiguet M; Service des Maladies Infectieuses et tropicales, Hopital; Saint-Antoine, Paris.; As many factors may be involved in therapeutic response to triple therapy with protease inhibitor (PI), the aim of this study was to determine the influence of epidemiological factors (sex, risk factors), clinical status (previous number of AIDS defining events), immunological status (baseline CD4 T cells count), viro
The effectiveness of preoperative erythropoietin in averting allogenic blood transfusion among children undergoing scoliosis surgery.: J Pediatr Orthop B. 1998 Jul;7(3):203-9. Unique Identifier : AIDSLINE MED/98368052; Vitale MG; Stazzone EJ; Gelijns AC; Moskowitz AJ; Roye DP Jr; New York Orthopaedic Hospital, New York, USA.; Concerns about the transmission of the human immunodeficiency virus (HIV) have driven the evolution of surgical transfusion practices including the use of preoperative erythropoietin (rhEPO). Although there is significant experience documenting the efficacy of preoperative rhEPO in reducing transfusion requirements fo
[Frequency of the coreceptor CCR5 gene delta 32 mutation in different French regions]: C R Acad Sci III. 1998 May;321(5):409-13. Unique Identifier : AIDSLINE MED/98439327; Lucotte G; Mercier G; Institut international d'anthropologie, Paris, France.; We studied the frequency of the coreceptor CCR5 gene delta 32 mutation on 1,836 DNA samples originating from ten French regions. This mutation confers, in the homozygous state, resistance to HIV-1 infection. For the whole territory, the mean percentage presence of the delta 32 mutation is 9.2%. The mutation is statist
[Astrocytes and lentivirus infection in an experimental models of macaque infected with SIVmac251]: C R Seances Soc Biol Fil. 1998;192(1):179-86. Unique Identifier : AIDSLINE MED/98431525; Guillemin G; Croitoru J; Boussin FD; Le Grand R; Franck-Duchenne M; Dormont D; Service de Neurovirologie, Commissariat a l'energie atomique,; DSV/DRM, Fontenay-aux-Roses. g.guillemin@cfi.UNSW.EDU.au; The present study demonstrates the susceptibility of astrocytes to infection with SIVmac251. Indeed, primary cultures of astrocytes derived from simian adult brains, can be infected in vitro with the SIVmac251. Results show that SIVmac251 establishes a persistent infection in primary astroglial cultures and that viral
Factors associated with Mexico City dentists' willingness to treat AIDS/HIV-positive patients.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Aug;86(2):169-74. Unique Identifier : AIDSLINE MED/98386560; Irigoyen M; Zepeda M; Lopez-Camara V; Health Care Department, Autonomous Metropolitan; University-Xochimilco, Mexico City, Mexico.; OBJECTIVE: The purpose of this study was to investigate the characteristics and infection control practices of dentists in Mexico City in relation to their willingness to treat AIDS/HIV-positive patients. STUDY DESIGN: The population study encompassed Mexico City dentists who were selected according to a geographic cr
Visceral leishmaniasis: a lingual presentation in a patient with HIV infection.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Aug;86(2):179-82. Unique Identifier : AIDSLINE MED/98386562; Vazquez-Pineiro T; Fernandez Alvarez JM; Gonzalo Lafuente JC; Cano J; Gimeno M; Berenguer J; Department of Oral Medicine, Hospital General Universitario; Gregorio Maranon, Madrid, Spain.; The term leishmaniasis covers a series of illnesses caused by the protozoan Leishmania; depending on the patient s immune response, the particular species of the protozoan, and the geography, the condition may manifest itself as cutaneous, mucocutaneous, or visceral disease. Visceral leishmaniasis has often been found
Apoptosis-associated proteins in oral lymphomas from HIV-positive patients.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Aug;86(2):196-202. Unique Identifier : AIDSLINE MED/98386565; Regezi JA; McMillan A; Dekker N; Daniels TE; Silverman S Jr; Schoelch M; Ziober BL; Department of Stomatology, UCSF, USA.; Extranodal oral lymphomas, seen with increasing frequency in HIV infection, may have dysfunctional apoptotic mechanisms that favor tumor progression. The purpose of this study was to evaluate extranodal lymphomas from HIV-positive patients for expression of apoptosis-associated proteins. Correlations were made with 10
Oral histoplasmosis as an indicator of HIV infection.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Aug;86(2):203-6. Unique Identifier : AIDSLINE MED/98386566; Economopoulou P; Laskaris G; Kittas C; Dental School, University of Athens, Greece.; Histoplasmosis as a serious opportunistic infection in association with AIDS has assumed considerable importance. We have gathered 20 case reports from the literature of oral histoplasmosis in HIV-infected patients. In some cases, oral lesions appear to be the primary or only manifestation of disease. We report one su
Financial issues in defining levels for HIV/AIDS research.: J Health Care Finance. 1998 Fall;25(1):19-25. Unique Identifier : AIDSLINE MED/98384620; Eastaugh SR; Department of Health Policy and Management, School of Public; Health and Health Services, George Washington University,; Washington, DC, USA.; This article outlines the issues in cost identification and fair payment for acquired immune deficiency syndrome (AIDS) research. Costs need to be better identified using activity-based costing methods to reveal the structural pattern of care. Patterns of care can be too expensive if they: (1) overutilize the hospital
What ever happened to confidentiality?: Br Dent Nurs J. 1998 Summer;57(2):11. Unique Identifier : AIDSLINE MED/99016923; Slade G
The transcription factor NFAT4 is involved in the generation and survival of T cells.: Immunity. 1998 Sep;9(3):295-304. Unique Identifier : AIDSLINE MED/98439685; Oukka M; Ho IC; de la Brousse FC; Hoey T; Grusby MJ; Glimcher LH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115, USA.; Nuclear factor of activated T cells (NFAT) is a family of four related transcription factors implicated in cytokine and early response gene expression in activated lymphocytes. Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes. Mice lacking NFAT4 have impaired deve
Impaired development of Th2 cells in IL-13-deficient mice.: Immunity. 1998 Sep;9(3):423-32. Unique Identifier : AIDSLINE MED/98439698; McKenzie GJ; Emson CL; Bell SE; Anderson S; Fallon P; Zurawski G; Murray R; Grencis R; McKenzie AN; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.; We report that Th2 cell cultures generated using T cells or splenocytes from IL-13-deficient mice produce significantly reduced levels of IL-4, IL-5, and IL-10 compared with wild-type. In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected. In v
HIV nef: the mother of all evil?: Immunity. 1998 Oct;9(4):433-7. Unique Identifier : AIDSLINE MED/99021466; Peter F; Institute of Molecular and Cell Biology, Singapore, Republic of; Singapore. mcbpfj@imcb.nus.edu.sg
Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection.: Immunity. 1998 Oct;9(4):449-57. Unique Identifier : AIDSLINE MED/99021468; Oxenius A; Zinkernagel RM; Hengartner H; Institute of Experimental Immunology, Department of Pathology,; University of Zurich, Switzerland. aoxenius@pathol.unizh.ch; The functional status of CD4+ T cells during establishment of persistent infection with the noncytopathic lymphocytic choriomeningitis virus was assessed and compared to that of cytotoxic CD8+ T cells. Functionality of virus-specific CD4+ T cells was measured by proliferative responses, cytokine secretion, cognate hel
CD8 expression allows T cell signaling by monomeric peptide-MHC complexes.: Immunity. 1998 Oct;9(4):467-73. Unique Identifier : AIDSLINE MED/99021470; Delon J; Gregoire C; Malissen B; Darche S; Lemaitre F; Kourilsky P; Abastado JP; Trautmann A; Laboratoire d'Immunologie Cellulaire UMR CNRS 7627 CERVI, Paris,; France.; Physiologically, TCR signaling is unlikely to result from the cross-linking of TCR-CD3 complexes, given the low density of specific peptide-MHC complexes on antigen-presenting cells. We therefore have tested directly an alternative model for antigen recognition. We show that monomers of soluble peptide-MHC trigger Ca2
Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.: Immunity. 1998 Oct;9(4):485-96. Unique Identifier : AIDSLINE MED/99021472; Ellmeier W; Sunshine MJ; Losos K; Littman DR; Molecular Pathogenesis Program, Skirball Institute of; Biomolecular Medicine, New York University Medical Center, New; York 10016, USA. ellmeier@saturn.med.nyu.edu; We and others have recently identified a CD8 locus enhancer (E8) that directs expression in mature CD8 single-positive thymocytes and peripheral CD8+ T cells and in extrathymically derived intestinal intraepithelial lymphocytes (IEL). In this study, we show that deletion of E8, by homologous recombination results in r
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.: Immunity. 1998 Oct;9(4):575-85. Unique Identifier : AIDSLINE GENBANK/AF052469; Yang DD; Conze D; Whitmarsh AJ; Barrett T; Davis RJ; Rincon M; Flavell RA; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut 06520, USA.; Precursor CD4+ T cells develop into effector Th1 and Th2 cells that play a central role in the immune response. We show that the JNK MAP kinase pathway is induced in Th1 but not in Th2 effector cells upon antigen stimulation. Further, the differentiation of precursor CD4+ T cells into effector Th1 but not Th2 cells is
HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.: Neuroimmunomodulation. 1998 May-Aug;5(3-4):184-92. Unique Identifier : AIDSLINE MED/98400136; Mayne M; Bratanich AC; Chen P; Rana F; Nath A; Power C; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.; Activation and infection by HIV-1 of glial cells and infiltrating macrophages are cardinal features of AIDS-related neurological disease. Tumor necrosis factor-alpha (TNF-alpha) is released by these cell types, and increased TNF-alpha mRNA and protein levels are associated with the development and severity of HIV-indu
[Progress in the study of communicable diseases in China, 1997]: Chung Hua I Hsueh Tsa Chih. 1997 Dec;77(12):893-5. Unique Identifier : AIDSLINE MED/98445727; Luo K; Liang Z
[Relation between AIDS, spleen and splenectomy]: Chung Hua I Hsueh Tsa Chih. 1997 Sep;77(9):718-20. Unique Identifier : AIDSLINE MED/98445720; Qui Q; Chen W
Sugar transport and glut transporter expression in a variety of human immunodeficiency virus-1 (HIV-1) chronically infected target cell lines.: Int J Biochem Cell Biol. 1998 Sep;30(9):1031-8. Unique Identifier : AIDSLINE MED/99001645; Caro C; Colby-Germinario S; Brenner B; Oliveira M; Wainberg MA; Germinario RJ; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Que., Canada.; In this study, sugar transport and the cellular content of the human Glut 1 and 3 glucose transporters were ascertained in uninfected and chronically HIV-infected Jurkat and H9 cell lines (T-cell lines) and U937 cells (a promonocytic cell line). Sugar transport was determined by monitoring 2-deoxy glucose uptake (2DG)
Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection.: Int J Biochem Cell Biol. 1998 Sep;30(9):1055-62. Unique Identifier : AIDSLINE MED/99001648; Puddu P; Borghi P; Gessani S; Valenti P; Belardelli F; Seganti L; Laboratory of Immunology, Istituto Superiore di Sanita, Rome,; Italy.; Lactoferrin is a mammalian iron-binding glycoprotein present in many biological secretions, such as milk, tears, semen and plasma and a major component of the specific granules of polymorphonuclear leucocytes. The effect of bovine lactoferrin (BLf) in apo-form or saturated with ferric, manganese or zinc ions, on human
Infection of T cell subsets by HIV-1 and the effects of interleukin-12.: J Interferon Cytokine Res. 1998 Jul;18(7):521-8. Unique Identifier : AIDSLINE MED/98376213; Salgame P; Guan MX; Agahtehrani A; Henderson EE; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; salgame@astro.ocis.temple.edu; CD4+ lymphocytes constitute one of the major cell targets for human immunodeficiency virus type 1 (HIV-1) infection. The eventual loss of CD4+ lymphocytes contributes substantially to the pathogenesis of HIV-1 and development of acquired immunodeficiency syndrome (AIDS). CD4+ lymphocytes consist of the subgroups Th1,
Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype.: J Interferon Cytokine Res. 1998 Jul;18(7):537-47. Unique Identifier : AIDSLINE MED/98376215; Kim JJ; Maguire HC Jr; Nottingham LK; Morrison LD; Tsai A; Sin JI; Chalian AA; Weiner DB; Department of Chemical Engineering, University of Pennsylvania,; Philadelphia 19104, USA.; Cytokines are important regulators of the immune response. They influence immune expression, the development of immunologic memory, and regulation of antigen-specific and nonspecific immune activation as well as allergic responses. In a model system in mice, we have studied the effect of plasmids expressing interleuki
Which is the true regulator of TH2 cell development in allergic immune responses? [editorial; comment]: Clin Exp Allergy. 1998 Aug;28(8):908-10. Unique Identifier : AIDSLINE MED/98427622; Kirman J; Le Gros G
Restoration of cytokine imbalance by immunotherapy [editorial; comment]: Clin Exp Allergy. 1998 Aug;28(8):917-20. Unique Identifier : AIDSLINE MED/98427624; Mavroleon G
Impaired NK1.1+ T cells do not prevent the development of an IgE-dependent allergic phenotype [see comments]: Clin Exp Allergy. 1998 Aug;28(8):950-5. Unique Identifier : AIDSLINE MED/98427629; Daser A; Gerstner B; Hansen R; Bulfone-Paus S; Renz H; Institute of Clinical Chemistry and Biochemistry, Virchow Clinics; of the Humboldt University, Berlin, Germany.; BACKGROUND: The induction of TH2 immune responses is critically dependent on initial IL-4. Although crucial, the source of this early IL-4 has not been identified. One candidate is a CD1 restricted NK1.1+ T cell subpopulation which is known to produce such early IL-4. OBJECTIVES AND METHODS: The necessity of NK1.1+ T
Assessment of ventricular diastolic function in AIDS patients from Congo: a Doppler echocardiographic study.: Heart. 1998 Aug;80(2):184-9. Unique Identifier : AIDSLINE MED/99031110; Longo-Mbenza B; Seghers LV; Vita EK; Tonduangu K; Bayekula M; Heart of Africa Cardiovascular Centre, Lomo Medical,; Kinshasa/Limete, Congo.; OBJECTIVE: To investigate the prevalence of left ventricular dysfunction in African patients infected with the human immunodeficiency virus (HIV). The hypothesis was that HIV infected patients with left ventricular dysfunction are asymptomatic. METHODS: M mode, cross sectional, and Doppler echocardiography were perfor
[Quantitative determination of HBV-DNA in chronic hepatitis B: comparison of three methods]: Gastroenterol Hepatol. 1998 Aug-Sep;21(7):327-31. Unique Identifier : AIDSLINE MED/99026423; Jardi R; Buti M; Cotrina M; Rodriguez-Frias F; Costa X; Pascual C; Esteban R; Guardia J; Servicio de Bioquimica, Hospital General Vall d'Hebron,; Barcelona.; The aim of this study was to evaluate a technique of quantitative determination of DNA-HBV in serum, bDNA Quantiplex, in a series of 90 patients with chronic HBV infection: 75 with chronic hepatitis B (24 HBeAg positive and 51 with anti-HBe) and 15 asymptomatic carriers of HBV (anti-HBe positive). The results were rel
[Diarrhea in the AIDS patient]: Gastroenterol Hepatol. 1998 Aug-Sep;21(7):352-60. Unique Identifier : AIDSLINE MED/99026429; Bixquert M; Gonzalvo JM; Servicio de Digestivo, Hospital Arnau de Vilanova, Facultad de; Medicina, Universidad de Valencia.
Local understandings of adult diarrhoeal disease and its treatment in an area of high HIV-seroprevalence in Zambia.: Trop Med Int Health. 1998 Oct;3(10):783-7. Unique Identifier : AIDSLINE MED/99025783; Ndubani P; Kelly P; Farthing MJ; Wallman S; Institute of Economic and Social Research, Lusaka, Zambia.; We set out to investigate the extent to which cultural constructs might determine treatment-seeking for diarrhoea in the poorer populations of Lusaka, Zambia . This paper describes these concepts and perceptions and outlines a classification of such illnesses, together with an analy
Clarifying AIDS vaccine trial guidelines [letter]: Nat Med. 1998 Oct;4(10):1091. Unique Identifier : AIDSLINE MED/98442665; Cohen J
New research centers created worldwide [news]: Nat Med. 1998 Oct;4(10):1097-8. Unique Identifier : AIDSLINE MED/98442671; Birmingham K; Bosch X
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.: Nat Med. 1998 Oct;4(10):1182-4. Unique Identifier : AIDSLINE MED/98442696; Corder EH; Robertson K; Lannfelt L; Bogdanovic N; Eggertsen G; Wilkins J; Hall C; Genetic Epidemiology, Odense University, Denmark.; beth@cds.duke.edu; HIV produces a chronic viral infection of the central nervous system that elicits chronic glial activation and overexpression of glial cytokines that are also implicated in Alzheimer disease (AD) pathogenesis. A genetic risk factor for AD is the E4 isoform for apolipoprotein E (APOE). Here we compare the frequency of
Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge.: Nat Med. 1998 Oct;4(10):1193-6. Unique Identifier : AIDSLINE MED/98442699; Hislop AD; Good MF; Mateo L; Gardner J; Gatei MH; Daniel RC; Meyers BV; Lavin MF; Suhrbier A; The Co-operative Research Centre for Vaccine Technology, The; Queensland Institute of Medical Research, PO Royal Brisbane; Hospital, Australia.; The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic T-lymphocyte (CTL), CD4-lymphocyteS, chemokine and/or antibody responses have all been associated with protection against HIV and AIDS; however, effective and safe va
Hepatitis B vaccination [letter]: J Can Dent Assoc. 1998 Oct;64(9):612. Unique Identifier : AIDSLINE MED/99028970; Ames H
[Drug injection method risky for transmission of blood-borne diseases: are we careful enough?]: Rev Esp Salud Publica. 1998 Jul-Aug;72(4):289-301. Unique Identifier : AIDSLINE MED/99028541; Bravo Portela MJ; Ortiz Castro A; Galvan Reyes J; Barrio Anta G; de la Fuente de Hoz L; Division de Investigaciones Epidemiologicas y Sociales.; Instituto Mexicano de Psiquiatria. lfuente@arrakis.es; In the last 20 years, research on the determinants of the HIV epidemic among drug users has focused mainly on studies of risk behaviour for drug injection. Studies involving human behaviour present special methodological problems. This paper presents a review of 1) the most important features that make this field diff
Vitravene--another piece in the mosaic [editorial]: Antisense Nucleic Acid Drug Dev. 1998 Aug;8(4):vii-viii. Unique Identifier : AIDSLINE MED/98414420; Crooke ST
Seronegative myasthenia gravis and human immunodeficiency virus infection: response to intravenous gamma globulin and prednisone.: Can J Neurol Sci. 1998 Aug;25(3):254-6. Unique Identifier : AIDSLINE MED/98372028; Strong J; Zochodne DW; Department of Clinical Neurosciences, University of Calgary,; Alberta, Canada.; BACKGROUND: There are only rare reports of myasthenia gravis complicating human immunodeficiency virus infection. The role of immunomodulatory therapy is unknown. METHODS: Case report and literature review. RESULTS: The diagnosis of human immunodeficiency virus infection followed that of myasthenia gravis in a 35-year
Atypical sporadic lymphosarcoma in a 7-month-old Holstein heifer.: Can Vet J. 1998 Jul;39(7):431-3. Unique Identifier : AIDSLINE MED/98431675; Dubreuil P; Lanevschi A; Perrone MA; Desnoyers M; Faculte de medecine veterinaire, Universite de Montreal,; Department of Clinical Sciences, St. Hyacinthe, Quebec.; A 7-month-old calf with a firm, diffuse infiltration of the left hind limb with sciatic nerve motor deficit was presented. The cytology indicated a malignant, round cell tumor and at necropsy, tissues were positive to a Kappa-lambda immunohistochemistry test. The final diagnosis was sporadic bovine leukosis, juvenile
Computational coevolution of antiviral drug resistance.: Artif Life. 1998 Winter;4(1):41-59. Unique Identifier : AIDSLINE MED/99015008; Rosin CD; Belew RK; Morris GM; Olson AJ; Goodsell DS; Scripps Research Institute, La Jolla, CA 92037, USA.; crosin@scripps.edu; An understanding of antiviral drug resistance is important in the design of effective drugs. Comprehensive features of the interaction between drug designs and resistance mutations are difficult to study experimentally because of the very large numbers of drugs and mutants involved. We describe a computational framewo
Knowledge and practices about HIV/AIDS among the commercial sex workers in Bangladesh.: J Epidemiol. 1998 Aug;8(3):181-3. Unique Identifier : AIDSLINE MED/98455995; Rahman M; Wali-ul Islam M; Fukui T; Department of General Medicine and Clinical Epidemiology, Kyoto; University School of Medicine, Japan.; A survey on knowledge and practices of 228 Bangladeshi commercial sex workers (CSWs) concerning AIDS was conducted in the largest brothel in Narayangonj, 20 km from the capital Dhaka in September through December, 1993. Only 18% of the respondents heard about AIDS and 8% knew about its propensity to sexual transmissio
Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replication.: J Neurovirol. 1998 Aug;4(4):377-86. Unique Identifier : AIDSLINE MED/98382255; Gorry P; Purcell D; Howard J; McPhee D; AIDS Cellular Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield, Victoria, Australia.; A small percentage of astrocytes are consistently infected in vivo by HIV-1 and may contribute to neuropathogenesis despite a non-productive infection. Overexpression of the nef gene product has been associated with their infection both in vivo and in vitro. We examined the role of the nef gene during HIV replication
Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.: J Neurovirol. 1998 Aug;4(4):387-93. Unique Identifier : AIDSLINE MED/98382256; Bratanich AC; Liu C; McArthur JC; Fudyk T; Glass JD; Mittoo S; Klassen GA; Power C; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.; HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia , brain-derived ta
Identification of SV40 in brain, kidney and urine of healthy and SIV-infected rhesus monkeys.: J Neurovirol. 1998 Aug;4(4):394-406. Unique Identifier : AIDSLINE MED/98382257; Newman JS; Baskin GB; Frisque RJ; Department of Biochemistry and Molecular Biology, Pennsylvania; State University, University Park 16802, USA.; Recent reports of simian virus 40 (SV40) sequences in human tumors have prompted investigations into the poorly understood association of this polyomavirus with its primate host, the rhesus monkey (Macaca mulatta). In the present study we have used PCR to analyze tissues from 20 monkeys for the presence of SV40. Five
Apoptosis induction in brain during the fixed strain of rabies virus infection correlates with onset and severity of illness.: J Neurovirol. 1998 Aug;4(4):407-14. Unique Identifier : AIDSLINE MED/98382258; Theerasurakarn S; Ubol S; Department of Microbiology, Faculty of Science, Mahidol; University, Bangkok, Thailand.; Viruses such as HIV, influenza, picornavirus and others are known stimulators of apoptosis. This individual cellular elimination is a preferential host defense in regenerative tissues. In contrast, if this death occurred in nonregenerating cells, such as neurons of the central nervous system, may result in disease. Th
Neurotoxic effects of feline immunodeficiency virus, FIV-PPR.: J Neurovirol. 1998 Aug;4(4):415-25. Unique Identifier : AIDSLINE MED/98382259; Gruol DL; Yu N; Parsons KL; Billaud JN; Elder JH; Phillips TR; Neuropharmacology, The Scripps Research Institute, La Jolla,; California 92037, USA.; FIV is a lentivirus of domestic cats that causes neurologic disorders which are remarkably similar to those found in HIV-1 infected people. Using feline neuron cultures, we investigated the potential of both FIV virus and FIV-Env protein to cause neuronal damage through the excitotoxicity mechanism. The neuron swellin
Thermosensory threshold: a sensitive test of HIV associated peripheral neuropathy?: J Neurovirol. 1998 Aug;4(4):433-7. Unique Identifier : AIDSLINE MED/98382261; Huengsberg M; Winer JB; Ross JD; Shahmanesh M; Department of GU Medicine, University Hospital Birmingham NHS; Trust, West Midlands, UK.; The purpose of the study was to assess the prevalence of thermosensory abnormalities in patients infected with HIV infection. Using a Thermo Sensory Analyser, we assessed thermosensory threshold for warm sensation (WS) and cold sensation (CS) of the forearm and foot in 40 controls and 75 HIV positive patients, includi
The efficacy of nucleoside analogs against JC virus multiplication in a persistently infected human fetal brain cell line.: J Neurovirol. 1998 Aug;4(4):451-6. Unique Identifier : AIDSLINE MED/98382264; Hou J; Major EO; Laboratory of Molecular Medicine and Neuroscience, National; Institute of Neurological Disorders and Stroke, National; Institutes of Health, Bethesda, MD 20892, USA.; The effectiveness of nucleoside analogs in blocking viral multiplication was evaluated using an immortalized human neuroglial cell line capable of sustaining a persistent JCV infection, SVG-JC. Results from in situ DNA hybridization and hemagglutination assays performed on drug treated cultures were used as a measure
VZV fulminant necrotizing encephalitis with concomitant EBV-related lymphoma and CMV ventriculitis: report of an AIDS case.: J Neurovirol. 1998 Aug;4(4):457-60. Unique Identifier : AIDSLINE MED/98382265; Nebuloni M; Vago L; Boldorini R; Bonetto S; Costanzi G; Pathology Unit, L. Sacco Institute of Medical Science, University; of Milan, Italy.; A case of AIDS with varicella zoster virus fulminant necrotizing encephalitis associated with cytomegalovirus ependymitis-subependymitis and a periventricular Epstein-Barr virus-related lymphoma is described. The patient had no herpes zoster cutaneous eruptions and died three days
Tumor defense by murine cytotoxic T cells specific for peptide bound to nonclassical MHC class I.: Cancer Res. 1998 Oct 15;58(20):4682-7. Unique Identifier : AIDSLINE MED/99002671; Griffiths E; Ong H; Soloski MJ; Bachmann MF; Ohashi PS; Speiser DE; Department of Medical Biophysics, Ontario Cancer Institute,; University of Toronto, Canada.; Cytotoxic T Cells (CTLs) can exhibit considerable antitumor activity. Thus far, the characterized tumor peptide antigens recognized by CTLs are all presented by classical MHC class Ia molecules [human lymphocyte antigen A (HLA-A), HLA-B, and HLA-C in humans and H-2K, H-2D, and H-2L in mice]. Here we show that CTLs rec
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.: Cancer Res. 1998 Oct 15;58(20):4688-93. Unique Identifier : AIDSLINE MED/99002672; Russ G; Ramachandra M; Hrycyna CA; Gottesman MM; Pastan I; Bennink JR; Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-0440, USA.; Most antigenic peptides presented to CD8+ T cells are generated from cytosolic precursors and are translocated by TAP into the endoplasmic reticulum, where they associate with MHC class I molecules. TAP-deficient cells exhibit a limited capacity to deliver peptides from cytosolic proteins to class I molecules. One can
Resolution of severe Kaposi's sarcoma after initiation of antiretroviral triple therapy.: Eur J Med Res. 1998 Sep 17;3(9):439-42. Unique Identifier : AIDSLINE MED/98409692; Jung C; Bogner JR; Goebel F; Medizinische Poliklinik des Klinikum Innenstadt,; Infektionsambulanz, Pettenkoferstr. 8a, D-80336 Munich, Germany.; mgross@pk-i.med.uni-muenchen.de; OBJECTIVES: To study the relationship between effective antiretroviral therapy, monitored by CD4 counts, and it s influence on the clinical course of AIDS associated Kaposi s sarcoma. METHODS: Four representative cases with AIDS and advanced Kaposi s sarcoma (KS) showed improvement of histologically proven KS s in var
Treatment of AIDS-related complications. 12th World-AIDS-Conference, June 1998, Geneva.: Eur J Med Res. 1998 Sep 17;3(9):449-52. Unique Identifier : AIDSLINE MED/98409694; Tossing G; Coordination Virology, ESSEX PHARMA GmbH, Tannenstrasse 15/15a,; D-42653 Solingen, Germany. gudrun.tossing@essex.de
RNA binding and modulation of PKR activity.: Methods. 1998 Jul;15(3):189-98. Unique Identifier : AIDSLINE MED/98410624; Gunnery S; Mathews MB; Department of Biochemistry and Molecular Biology, New Jersey; Medical School, UMDNJ, 185 South Orange Avenue, University; Heights, Newark, New Jersey, 07103, USA.; PKR is an RNA-dependent protein kinase that is induced in mammalian cells by interferon treatment. It is present in a latent or inactive form in mammalian cells and is activated by very low concentrations of double-stranded (ds) RNA. Activated PKR phosphorylates eIF2, an essential initiation factor of protein synthesi
Regulation of gene expression by HTLV-I Tax protein.: Methods. 1998 Sep;16(1):83-94. Unique Identifier : AIDSLINE MED/98450017; Bex F; Gaynor RB; Departments of Internal Medicine, University of Texas; Southwestern Medical Center, Dallas, Texas, 75235-8594, USA.; The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A protein encoded by HTLV-I, Tax, activates viral gene expression and is essential for transforming T-lymphocytes. Tax activates HTLV-I gene expression via interactions with the ATF/CREB proteins and the coactivators CBP/
Concerns and dilemmas of Hispanic AIDS information seekers: Spanish-speaking callers to the CDC National AIDS hotline.: Health Educ Behav. 1998 Aug;25(4):501-16. Unique Identifier : AIDSLINE MED/98354564; Scott SA; Jorgensen CM; Suarez L; CDC Hotlines Project, Research Triangle Park, NC 27709, USA.; shesco@ashastd.org; Hispanic communities suffer disproportionately from the impact of human immunodeficiency virus infection (HIV). Each year, thousands of Spanish-speaking Hispanics call the Centers for Disease Control and Prevention National AIDS Hotline to ask questions about HIV. During 1995 alone, Spanish line staff answered more th
Roche integrates HIV therapeutics and diagnostics [news]: Nat Biotechnol. 1998 Sep;16(9):815. Unique Identifier : AIDSLINE MED/98414036; Robertson D
HERV-K10s and immune-mediated (type 1) diabetes.: Cell. 1998 Oct 2;95(1):14-6; discussion 16. Unique Identifier : AIDSLINE GENBANK/AF086870; Lan MS; Mason A; Coutant R; Chen QY; Vargas A; Rao J; Gomez R; Chalew S; Garry R; Maclaren NK; Department of Pediatrics, Louisiana State University Medical; School, Research Institute for Children, Children's Hospital,; Harahan 70123, USA.
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.: Cell. 1998 Oct 2;95(1):93-104. Unique Identifier : AIDSLINE MED/98449699; Armstrong JA; Bieker JJ; Emerson BM; Regulatory Biology Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; Erythroid Kruppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.: Cell. 1998 Oct 16;95(2):163-75. Unique Identifier : AIDSLINE MED/99005185; Hanna Z; Kay DG; Rebai N; Guimond A; Jothy S; Jolicoeur P; Clinical Research Institute of Montreal, Department of Medicine,; Universite de Montreal, Quebec, Canada.; Transgenic (Tg) mice expressing the complete coding sequences of HIV-1 in CD4+ T cells and in cells of the macrophage/dendritic lineages develop severe AIDS-like pathologies: failure to thrive/weight loss, diarrhea, wasting, premature death, thymus atrophy, loss of CD4+ T cells, interstitial pneumonitis, and tubulo-in
Decreased protein levels of the c-Cbl protooncogene in murine AIDS.: Cell Immunol. 1998 Sep 15;188(2):151-7. Unique Identifier : AIDSLINE MED/98437271; Trebak M; Lambert CA; Rahmouni S; Debrus S; Defresne MP; Regnier D; Boniver J; Moutschen M; Laboratory of Pathology, University of Liege, Liege, 4000,; Belgium.; Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer s patches do not participate in the process. The 120-kDa protooncogene product c-Cbl was initially cloned from the murine Cas NS-
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.: Cell Immunol. 1998 Nov 1;189(2):160-8. Unique Identifier : AIDSLINE MED/99008957; Ruffing N; Sullivan N; Sharmeen L; Sodroski J; Wu L; LeukoSite, Inc., 215 First Street, Cambridge, Massachusetts,; 02142, USA.; CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou
The interpretation of clinical trials of immediate versus delayed therapy.: Lifetime Data Anal. 1998;4(3):253-63. Unique Identifier : AIDSLINE MED/99003873; Mittlbock M; Whitehead J; Department of Medical Computer Science, University of Vienna,; Austria.; Prospective, randomised clinical comparisons with a control group are the ideal way to evaluate the effectiveness of a new therapy. However if the new therapy is already available, then it may be unethical to refuse patients this treatment indefinitely. In some trials, patients randomised to the control group receive
Mood disorders in HIV infection.: Depress Anxiety. 1998;7(4):178-87. Unique Identifier : AIDSLINE MED/98371744; Treisman G; Fishman M; Schwartz J; Hutton H; Lyketsos C; Department of Psychiatry and Behavioral Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21287-7419,; USA.
RNA recognition and regulation of HIV-1 gene expression by viral factor Tat.: Biochemistry (Mosc). 1998 May;63(5):489-503. Unique Identifier : AIDSLINE MED/98298338; Naryshkin NA; Gait MJ; Ivanovskaya MG; Belozersky Institute of Physico-Chemical Biology, Lomonosov; Moscow State University, Moscow, 119899, Russia.; mgi@nuclacid.genebee.msu.su; Viral transcription factor Tat is a small nuclear protein containing a large number of basic amino acids. The tat gene consists of two exons but only the first encoding 72-amino acid polypeptide is necessary for protein activity. Since the second exon is poorly conservative the total number of amino acids among Tat pr
Solid-phase synthesis and on-resin cyclization of a disulfide bond peptide and lactam analogues corresponding to the major antigenic site of HIV gp41 protein.: J Pept Res. 1998 Aug;52(2):121-9. Unique Identifier : AIDSLINE MED/98394851; Limal D; Briand JP; Dalbon P; Jolivet M; Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS,; Strasbourg, France. dlimal@ibmc.u-strasbg.fr; A cyclic peptide that spans the major antigenic determinant of the human immunodeficiency virus (HIV) glycoprotein 41 (gp41) has been synthesized according to various strategies. For immunodiagnostic applications, biotin was added at the N-terminus of the peptide and aminohexanoic acid was used as a spacer. Polymer-su
A study of the pharmacokinetics, antiviral activity, and tolerability of oral ganciclovir for CMV prophylaxis in marrow transplantation.: Biol Blood Marrow Transplant. 1998;4(1):13-9. Unique Identifier : AIDSLINE MED/98365117; Boeckh M; Zaia JA; Jung D; Skettino S; Chauncey TR; Bowden RA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024,; USA.; Oral ganciclovir is effective in preventing cytomegalovirus ( CMV ) disease in HIV-infected patients despite a bioavailability of only 6-9%. To determine safety, pharmacokinetics, and the influence of acute gastrointestinal gra
Simulation of alternative binding modes in a structure-based QSAR study of HIV-1 protease inhibitors.: J Mol Graph Model. 1997 Dec;15(6):364-71, 389. Unique Identifier : AIDSLINE MED/98369922; Pastor M; Perez C; Gago F; Department of Pharmacology, University of Alcala, Spain.; We have used a published set of inhibitors of HIV-1 protease to build a COMBINE-type structure-based QSAR model with good predictive ability (r2 = 0.90, q2 = 0.69). Since the compounds in the training series exhibit most of their structural variability on one-half of the pseudosymmetrical binding cavity and only one b
"Breakthrough" during interferon therapy for chronic hepatitis C. Overview on the diagnosis, possible aetiology and recommendations for management.: Ital J Gastroenterol Hepatol. 1998 Jun;30(3):333-7. Unique Identifier : AIDSLINE MED/98431771; Colloredo G; Roffi L; Bellati G; Department Internal Medicine, Bolognini Hospital, Seriate,; Bergamo, Italy.; A relapse of serum aminotransferase levels after complete normalisation during alpha interferon therapy for chronic hepatitis C is diagnosed as Breakthrough. Its prevalence ranges between 14% and 21% of the responders, with no significant differences between the alpha interferons. Hepatitis C virus genotype and interf
Notifying patients exposed to blood products associated with Creutzfeldt-Jakob disease: theoretical risk for real people [see comments]: CMAJ. 1998 Oct 6;159(7):771-4. Unique Identifier : AIDSLINE MED/99021838; King SM; Watson H; Heurter H; Ricketts M; Elsaadany S; Division of Infectious Diseases, Hospital for Sick Children,; Toronto, Ont.; BACKGROUND: In July 1995 the Canadian Red Cross Society recalled blood products because of the hypothetical risk of transmission of Creutzfeldt-Jakob disease (CJD) through those blood products. The authors undertook a survey to determine the views of patients and parents of patients about being notified that they or t
Application of a novel and fast information-theoretic method to the discovery of higher-order correlations in protein databases.: Pac Symp Biocomput. 1998;:573-84. Unique Identifier : AIDSLINE MED/98362539; Steeg EW; Pham H; Molecular Mining Corporation, Queen's University, Kingston,; Ontario, Canada. steeg@qucis.queensu.ca; We present a fast, discrete data-mining approach to the problem of finding kappa-tuples of correlated amino acid residues in protein sequence data. When sets of sequence-distant sites display high mutual information, they may bespeak important structural or functional features. Our novel methodology overcomes the limi
Quantitative determination of (-)-2'-deoxy-3'-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chromatography with ultraviolet detection.: J Chromatogr B Biomed Sci Appl. 1998 Aug 25;713(2):387-94. Unique Identifier : AIDSLINE MED/98417336; Hoetelmans RM; Profijt M; Mennhorst PL; Mulder JW; Beijnen JH; Department of Pharmacy & Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; A high-performance liquid chromatographic method for the quantitative determination of the HIV reverse transcriptase inhibitor lamivudine ((-)-2 -deoxy-3 -thiacytidine, 3TC , Epivir ) i
Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection.: J Chromatogr B Biomed Sci Appl. 1998 Aug 25;713(2):395-9. Unique Identifier : AIDSLINE MED/98417337; van Heeswijk RP; Hoetelmans RM; Meenhorst PL; Mulder JW; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; Nevirapine is a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1-infected patients. A simple and rapid high-performance liquid chromatographic method for the quantification of nevirapine in human plasma is described. Sample pr
Study of phosphorothioate-modified oligonucleotide resistance to 3'-exonuclease using capillary electrophoresis.: J Chromatogr B Biomed Sci Appl. 1998 Aug 28;714(1):13-20. Unique Identifier : AIDSLINE MED/98417312; Gilar M; Belenky A; Budman Y; Smisek DL; Cohen AS; Hybridon, Inc., Cambridge, MA 02139, USA.; The effect of phosphorothioate (PS) internucleotide linkages on the stability of phosphodiester oligodeoxyribonucleotides (ODNs) was investigated using 25-mer ODNs containing single or multiple PS backbone modifications. The in vitro stability of the oligomers was measured both in 3 -exonuclease solution and in plasma
On-line coupling of polymerase chain reaction and capillary electrophoresis for automatic DNA typing and HIV-1 diagnosis.: J Chromatogr B Biomed Sci Appl. 1998 Aug 28;714(1):3-11. Unique Identifier : AIDSLINE MED/98417311; Zhang N; Yeung ES; Ames Laboratory-USDOE and Department of Chemistry, Iowa State; University, 50011, USA.; We demonstrate an integrated on-line system with a fused-silica capillary as the microreactor for PCR and capillary gel electrophoresis with laser-induced fluorescence detection for DNA typing and disease diagnosis. Two applications have been investigated: the four short tandem repeat (STR) loci vWA, THO1, TPOX and CS
[The campaign against AIDS in west Africa: what perspectives at the end of the century? From the situation of the Cote d'Ivoire as observed from the period 1987-1997]: Sante Publique. 1998 Jun;10(2):203-18. Unique Identifier : AIDSLINE MED/98448044; Kerouedan D; Conseiller technique au Programme National de Lutte contre le; Sida, Madagascar.; WHO is commissioned to create the World AIDS Program and to elaborate the strategy for the fight against the AIDS pandemic. The standardised strategy for African countries developed in Geneva in 1987 favours the prevention of sexual transmission of HIV without communicating the methods for such. The external and exclu
Is the Gulf War syndrome an immunologically mediated phenomenon? [editorial]: Hosp Med. 1998 Jan;59(1):10-1. Unique Identifier : AIDSLINE MED/99015291; Rook GA; Zumla A
Psoriasis as a T cell-mediated autoimmune disease.: Hosp Med. 1998 Jul;59(7):530-3. Unique Identifier : AIDSLINE MED/99015274; Barker JN; Therapy Research Unit, St John's Institute of Dermatology, St; Thomas' Hospital, London.; Psoriasis is a common chronic skin disease in which T lymphocytes are thought to play a vital pathogenic role. Evidence shows that these are activated memory skin-homing T cells which induce characteristic disease features via cytokine production. Understanding the mechanisms of T cell accumulation in skin and mediati
Generation of HIV-1/HIV-2 cross-reactive peptide antisera by small sequence changes in HIV-1 reverse transcriptase and integrase immunizing peptides.: J Biomed Sci. 1998;5(3):192-202. Unique Identifier : AIDSLINE MED/98341630; Klutch M; Woerner AM; Marcus-Sekura CJ; Levin JG; Division of Viral Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, MD, USA.; We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were
Expression of HIV-1 nef in yeast causes membrane perturbation and release of the myristylated Nef protein.: J Biomed Sci. 1998;5(3):203-10. Unique Identifier : AIDSLINE MED/98341631; Macreadie IG; Fernley R; Castelli LA; Lucantoni A; White J; Azad A; Biomolecular Research Institute, Parkville, Vic., Australia.; Ian.Macreadie@molsci.csiro.au; The human immunodeficiency virus type 1 (HIV-1) Nef protein is essential for AIDS pathogenesis, but its function remains highly controversial. During stresses such as growth in the presence of copper or at elevated temperature, myristylated Nef is released from yeast cells and, after extended culture in stationary pha
Analysis of HIV-1 Tat effects in Xenopus laevis embryos.: J Biomed Sci. 1998;5(3):211-20. Unique Identifier : AIDSLINE MED/98341632; Venanzi S; Destree OH; Gigliani F; Battaglia PA; Reparto di Genetica Molecolare, Laboratorio di Biologia; Cellulare, Istituto Superiore di Sanita, Rome, Italy.; s.venanz@iss.it; Tat is one of the regulatory proteins of the HIV-1 virus. To date, besides the transactivation activity, a myriad of effects exerted by HIV-1 Tat on cellular and viral genes have been observed. The present study investigated the in vivo effects of HIV-1 Tat protein in the Xenopus embryo. We adopted the Xenopus system
Acquired trichomegaly of the eyelashes in a child with human immunodeficiency virus infection [letter]: J Eur Acad Dermatol Venereol. 1998 Jul;11(1):89-91. Unique Identifier : AIDSLINE MED/98400729; Patrizi A; Neri I; Trestini D; Landi C; Ricci G; Masi M
Host factors that affect sexual transmission of HIV [editorial; comment]: Int J Infect Dis. 1998 Apr-Jun;2(4):182-5. Unique Identifier : AIDSLINE MED/98437470; Cohen OJ; Fauci AS
CD3+CD8+ cell levels as predictors of transmission in human immunodeficiency virus-infected couples: a report from the heterosexual HIV transmission study [see comments]: Int J Infect Dis. 1998 Apr-Jun;2(4):186-92. Unique Identifier : AIDSLINE MED/98437471; Denny TN; Skurnick JH; Palumbo P; Perez G; Monel R; Stephens R; Kennedy CA; Louria DB; Department of Pathology and Laboratory Medicine, and Department; of Preventive Medicine and Community Health, UMDNJ-New Jersey; Medical School, Newark, New Jersey, USA.; OBJECTIVE: The goal of this study was to identify in human immunodeficiency virus (HIV)-infected individuals immunologic markers that correlated with transmission of HIV by heterosexual contact. METHODS: In a case-control comparison of couples, immunologic and viral parameters were evaluated in 343 HIV-positive indivi
Screening for human immunodeficiency virus type 1 and 2 in a Turkish blood donor population.: Int J Infect Dis. 1998 Apr-Jun;2(4):202-4. Unique Identifier : AIDSLINE MED/98437474; Altuglu I; Sayiner AA; Erensoy S; Zeytinoglu A; Bilgic A; Ege University, Blood Bank, Izmir, Turkey.; OBJECTIVES: To determine the prevalence of human immunodeficiency virus-1 and -2 infection in voluntary blood donors at a university hospital in the third largest city of Turkey and to evaluate the HIV testing strategy for notifying blood donors. METHODS: Between July 1995 and Augu
Evaluation of the serologic response against two consensus V3 loop peptides from human immunodeficiency virus-1 in Cuban patients.: Int J Infect Dis. 1998 Apr-Jun;2(4):221-5. Unique Identifier : AIDSLINE MED/98437478; Miguez J; Laferte J; Tejero Y; Gonzalez G; Otero AJ; Rivero J; Duarte C; Instituto de Medicina Tropical Pedro Kouri, Ciudad Havana, Cuba.; OBJECTIVES: A retrospective study was conducted to evaluate the antibody response of Cuban patients infected with human immunodeficiency virus (HIV)-1 against two consensus peptides from the third variable domain (V3) loop of glycoprotein gp120. METHODS: The study included sera from 10 individuals at different stages
Cross-presentation of self antigens to CD8+ T cells: the balance between tolerance and autoimmunity.: Novartis Found Symp. 1998;215:172-81; discussion 181-90. Unique Identifier : AIDSLINE MED/98433288; Kurts C; Heath WR; Carbone FR; Kosaka H; Miller JF; Walter and Eliza Hall Institute of Medical Research, Royal; Melbourne Hospital, Victoria, Australia.; Upon encounter with foreign antigen, tissue-associated antigen-presenting cells (APCs) migrate to draining lymph nodes to prime specific T cells. Using the transgenic RIP-mOVA model, we recently demonstrated that self antigens derived from peripheral tissues are constitutively transported to draining lymph nodes, and
Tolerance induction in mature T lymphocytes.: Novartis Found Symp. 1998;215:191-6; discussion 196-9, 218-30. Unique Identifier : AIDSLINE MED/98433289; Alferink J; Tafuri A; Klevenz A; Hammerling GJ; Arnold B; Division of Molecular Immunology, German Cancer Research Center,; Heidelberg, Germany.; T lymphocytes with self-destructive capacity are often found in healthy individuals, indicating efficient control mechanisms that prevent autoimmunity. Recently, we were able to demonstrate the existence of peripheral tolerance in double-transgenic mice expressing the foreign histocompatibility antigen H-2Kb exclusive
[Trends in HIV/AIDS-related knowledge, attitudes, and practices in a Rio de Janeiro slum population]: Cad Saude Publica. 1998 Jul-Sep;14(3):575-81. Unique Identifier : AIDSLINE MED/98434712; Fernandes JC; Posto de Saude da Associacao dos Moradores e Amigos do Bairro; Barcellos, Travessa Flores 4, Rio de Janeiro, RJ, 22451-000,; Brasil.; The study aims to evaluate the present stage of knowledge, attitudes, and behavior related to HIV/AIDS in the population of Rio de Janeiro s Rocinha slum, the target of a control program over the last 6 years. We interviewed two hundred and ten people of both sexes, ranging from 13 to 49 years of age, and the results
Detection of HHV-8 DNA in a German patient with classical Kaposi's sarcoma may allow an estimation of the incubation period.: Eur J Dermatol. 1998 Sep;8(6):432-4. Unique Identifier : AIDSLINE MED/98398548; Kowalzick L; Hoffmann I; Neipel F; Walter H; Schlehaider UK; Ponnighaus JM; Department of Dermatology, Municipal Hospital Plauen, PF 39,; 08505 Plauen, Germany.; DNA of HHV-8 (Kaposi s sarcoma-associated Herpes virus [KSHV]) was detected in a biopsy of a Kaposi s sarcoma in an elderly male patient from Saxony (East Germany ). The diagnosis of classical Kaposi s sarcoma was first made in 1986. During World War II, the patient had been on act
Peptidomimetic design.: Curr Opin Chem Biol. 1998 Aug;2(4):441-52. Unique Identifier : AIDSLINE MED/98408123; Ripka AS; Rich DH; Department of Chemistry and School of Pharmacy, University of; Wisconsin-Madison 53706, USA.; Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus p
Ovalbumin peptide encapsulated in poly(d,l lactic-co-glycolic acid) microspheres is capable of inducing a T helper type 1 immune response.: J Controlled Release. 1998 Jun;54(1):49-59. Unique Identifier : AIDSLINE MED/98412934; Newman KD; Samuel J; Kwon G; 3118 Dentistry/Pharmacy Centre, Faculty of Pharmacy &; Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.; An ovalbumin (OVA) peptide, consisting of residues 323-339, was incorporated into poly(d,l lactic-co-glycolic acid) (PLGA) microspheres and administered to mice. It was hypothesized that microencapsulation of the peptide in PLGA microspheres would avoid the need for traditional adjuvants and bias the immune response t
Nef--an adaptor adaptor?: Trends Cell Biol. 1998 Aug;8(8):302-5. Unique Identifier : AIDSLINE MED/98370028; Oldridge J; Marsh M; Research Council, Laboratory for Molecular Cell Biology,; University College, London, UK.; The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to end
Infections.: J Urban Health. 1998 Jun;75(2):251-7. Unique Identifier : AIDSLINE MED/98348862; Osborn JE; Josiah Macy, Jr., Foundation, New York, NY 10021, USA.
Births and deaths: preliminary data for 1997.: Natl Vital Stat Rep. 1998 Oct 7;47(4):1-41. Unique Identifier : AIDSLINE MED/99022297; Ventura SJ; Anderson RN; Martin JA; Smith BL; OBJECTIVES: This report presents preliminary data on births and deaths in the United States from the National Center for Health Statistics (NCHS) for 1997. U.S. data on births are shown by age, race, and Hispanic origin of mother. National and State data on marital status, prenatal car
Reproductive tract infections, gynaecological morbidity and HIV seroprevalence among women in Mumbai, India.: Bull World Health Organ. 1998;76(3):277-87. Unique Identifier : AIDSLINE MED/98416911; Brabin L; Gogate A; Gogate S; Karande A; Khanna R; Dollimore N; de Koning K; Nicholas S; Hart CA; Liverpool School of Tropical Medicine, England.; Reported are the prevalence of reproductive tract infections and their contribution to pelvic inflammatory disease (PID), as well as the seroprevalence of human immunodeficiency virus (HIV), among women living in three inner city wards of Mumbai, India . Women aged
Measurement and determinants of tuberculosis outcome in Karonga District, Malawi [see comments]: Bull World Health Organ. 1998;76(3):295-305. Unique Identifier : AIDSLINE MED/98416913; Glynn JR; Warndorff DK; Fine PE; Munthali MM; Sichone W; Ponnighaus JM; London School of Hygiene and Tropical Medicine, England.; Evaluation of disease outcome is central to the assessment of tuberculosis (TB) control programmes. In the study reported in this article we examined the factors influencing the measurement of outcome, survival rates during and after treatment, smear conversion rates, and relapse rates for patients diagnosed with TB i
Evaluation and determinants of outcome of tuberculosis treatment [comment]: Bull World Health Organ. 1998;76(3):307-8. Unique Identifier : AIDSLINE MED/98416914; Maher D; Nunn P; World Health Organization, Geneva, Switzerland.; The most important determinant of the outcome of treatment of tuberculosis (TB) patients is the access that they have to reliable diagnosis and treatment services organized within a national tuberculosis programme (NTP) as part of DOTS, the name of the WHO-recommended TB control strategy. Accurate evaluation of treatm
Rheumatologic manifestations of HIV-1 and HTLV-1 infections.: Cleve Clin J Med. 1998 Sep;65(8):436-41. Unique Identifier : AIDSLINE MED/98441701; Vassilopoulos D; Calabrese LH; Department of Rheumatic and Immunologic Diseases, Cleveland; Clinic Foundation, OH 44195, USA.; HIV infection is the new great mimic. Although its more common signs and symptoms are well known, HIV infection sometimes presents with rheumatologic manifestations, as does human T-cell lymphotrophic virus type I (HTLV-I), the causative agent of adult T-cell leukemia. This review briefly describes these manifestati
Apoptosis in labial salivary glands from Sjogren's syndrome (SS) patients: comparison with human T lymphotropic virus-I (HTLV-I)-seronegative and -seropositive SS patients.: Clin Exp Immunol. 1998 Oct;114(1):106-12. Unique Identifier : AIDSLINE MED/98435640; Nakamura H; Koji T; Tominaga M; Kawakami A; Migita K; Kawabe Y; Nakamura T; Shirabe S; Eguchi K; First Department of Internal Medicine, Nagasaki University School; of Medicine, Nagasaki City, Japan.; Apoptosis is a type of cell death that occurs during morphogenesis and development of the immune system. One of the mechanisms is mediated through the Fas and Fas ligand (FasL) pathway. To determine the possible involvement of Fas and its ligand in salivary gland destruction, we analysed the appearance of nuclei with
mRNA cytokine profile in peripheral blood cells from chronic hepatitis C virus (HCV)-infected patients: effects of interferon-alpha (IFN-alpha) treatment.: Clin Exp Immunol. 1998 Oct;114(1):55-60. Unique Identifier : AIDSLINE MED/98435632; Shapiro S; Gershtein V; Elias N; Zuckerman E; Salman N; Lahat N; Immunology Research Unit, Lady Davis Carmel Medical Centre,; Haifa, Israel.; Natural immune responses, both cellular and humoral, are not capable of terminating HCV infection in most patients. A role has been suggested for peripheral blood leucocytes (PBL) in viral persistence and clinical implications, as these cells may serve as a viral reservoir and at the same time may be inadequate active
Tumour necrosis factor (TNF) and TNF-related molecules in HIV-1+ individuals: relationship with in vitro Th1/Th2-type response.: Clin Exp Immunol. 1998 Oct;114(1):61-5. Unique Identifier : AIDSLINE MED/98435633; Rizzardi GP; Marriott JB; Cookson S; Lazzarin A; Dalgleish AG; Barcellini W; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.; We examined the secretion and expression by peripheral blood mononuclear cells (PBMC) of TNF-alpha and TNF-related molecules with regard to Th1/Th2-type cytokine production. In 76 HIV+ patients at different disease stages and in 25 controls we measured cytokine (TNF-alpha/beta, interferon-gamma (IFN-gamma),
Expression of the activation antigen CD69 predicts functionality of in vitro expanded peripheral blood mononuclear cells (PBMC) from healthy donors and HIV-infected patients.: Clin Exp Immunol. 1998 Oct;114(1):66-72. Unique Identifier : AIDSLINE MED/98435634; Nielsen SD; Afzelius P; Ersboll AK; Nielsen JO; Hansen JE; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; Gene therapy for AIDS necessitates harvest and expansion of PBMC from HIV-infected patients. We expanded PBMC from healthy blood donors and HIV-infected patients for up to 14 days using four expansion protocols: 3 days of phytohaemagglutinin (PHA) stimulation, continuous PHA stimulation, 3 days of stimulation with ant
Neutrophil adhesion molecules in HIV disease.: Clin Exp Immunol. 1998 Oct;114(1):73-7. Unique Identifier : AIDSLINE MED/98435635; Moore DA; Henderson D; Gazzard BG; Academic Department of Immunology, Chelsea & Westminster; Hospital, London, UK.; Neutrophil dysfunction in HIV disease is well described. We examined the expression of neutrophil adhesion molecules amongst 72 HIV-infected subjects using a whole blood flow cytometric assay with FITC- and R-PE-labelled isotype-specific MoAbs. We report lesser expression of CD11a (LFA-1) and L-selectin (CD62L) on the
Differential production of IL-10 by T cells and monocytes of HIV-infected individuals: association of IL-10 production with CD28-mediated immune responsiveness.: Clin Exp Immunol. 1998 Oct;114(1):78-86. Unique Identifier : AIDSLINE MED/98435636; Kumar A; Angel JB; Daftarian MP; Parato K; Cameron WD; Filion L; Diaz-Mitoma F; Division of Virology and Molecular Immunology, Research; Institute, Children's Hospital of Eastern Ontario, University of; Ottawa, Canada.; Immune unresponsiveness in HIV-1 infection can result from impaired signals delivered by the costimulatory CD28-B7 pathway and the altered production of immunoregulatory cytokines, in particular IL-10, whose production is altered in HIV-1 infection. In this study we investigate IL-10 regulation in T cells and monocyte
Enhancement of HIV-1 replication in human macrophages is induced by CD8+ T cell soluble factors.: Clin Exp Immunol. 1998 Oct;114(1):87-93. Unique Identifier : AIDSLINE MED/98435637; Copeland KF; McKay PJ; Newton JJ; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; We previously reported that CD8+ T cell-derived factors enhanced HIV long terminal repeat (LTR)-mediated gene expression and replication in monocytic cell lines. We now report that replication of NSI and SI primary isolates of HIV-1 in human macrophages were significantly enhanced by CD8+ T cell supernatants. The CD8-
Proposed CD4(+) T-cell criteria for staging human immunodeficiency virus-infected Chinese adults.: Clin Immunol Immunopathol. 1998 Oct;89(1):11-22. Unique Identifier : AIDSLINE MED/98434735; Kam KM; Wong KH; Li PCK; Lee SS; Leung WL; Kwok MY; Department of Health, Hong Kong Special Administrative Region; Government, Sai Ying Pun, Hong Kong.; The present treatment, prophylaxis, and prognostic staging of human immunodeficiency virus (HIV) disease rely heavily on peripheral CD4(+) T lymphocyte (CD4) changes. We correlated the clinical course of events and CD4 changes among consecutive HIV-infected ethnic Chinese adults in
Age-related persistent clonal expansions of CD28(-) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences.: Clin Immunol Immunopathol. 1998 Oct;89(1):61-70. Unique Identifier : AIDSLINE MED/98434741; Colombatti A; Doliana R; Schiappacassi M; Argentini C; Tonutti E; Feruglio C; Sala P; Divisione di Oncologia Sperimentale 2, Centro di Riferimento; Oncologico di Aviano, Italy.; In a small group of subjects we had identified persistent expansions (range 6-72%) of CD4(+)CD8(+) double-positive (DP) peripheral blood (PB) cells which express the CD8 alpha/alpha homodimer. Here, DP cells present in a larger cohort were further investigated and found by FACS analysis to express a single or a domina
Tumor and infection localization in AIDS patients: Ga-67 and Tl-201 findings.: Clin Nucl Med. 1998 Jul;23(7):446-59. Unique Identifier : AIDSLINE MED/98339604; Turoglu HT; Akisik MF; Naddaf SY; Omar WS; Kempf JS; Abdel-Dayem HM; Department of Radiology, St. Vincent's Hospital and Medical; Center of New York, New York 10011, USA.; Examples of Ga-67 and Tl-201 scans in AIDS patients performed at St. Vincent s Hospital and Medical Center of New York are presented. Use of these methods is the adopted approach at this institution in AIDS patients for localizing sites of tumor or infection involvement. A Ga-67 scan is the most common nuclear medicin
Pharmacokinetic interaction between ritonavir and clarithromycin.: Clin Pharmacol Ther. 1998 Oct;64(4):355-62. Unique Identifier : AIDSLINE MED/99014525; Ouellet D; Hsu A; Granneman GR; Carlson G; Cavanaugh J; Guenther H; Leonard JM; Abbott Laboratories, Abbott Park, Ill, USA.; BACKGROUND: Because ritonavir, a human immunodeficiency virus (HIV) protease inhibitor, and clarithromycin, a macrolide antibiotic used in the treatment of disseminated infection caused by Mycobacterium avium complex, are likely to be administered concurrently for treatment of patients with HIV and acquired immunodefi
Comparability of absolute/percent CD4+ T-lymphocytes completed locally and centrally. Hemophilia Growth and Development Study.: Control Clin Trials. 1998 Oct;19(5):451-60. Unique Identifier : AIDSLINE MED/98412897; Donfield SM; Mahoney EM; Maeder MA; Hawk SM; Sirois PA; Pearson SK; Goldberg IA; Richard SK; Baird-Cox KA; Hoel LN; Cool VA; Rho, Inc., Chapel Hill, North Carolina 27514, USA.; The Hemophilia Growth and Development Study (HGDS) is a multicenter longitudinal study of 333 male children and adolescents with moderate or severe hemophilia, ranging in age from 6 to 19 at entry. Sixty-two percent of the cohort was infected with human immunodeficiency virus (HIV) in the late 1970s and early 1980s th
Suicide, euthanasia and AIDS.: Crisis. 1998;19(2):87-96. Unique Identifier : AIDSLINE MED/99001829; Mishara BL; Universite du Quebec a Montreal, Quebec, Canada.; This article critically reviews research on suicide, AIDS, and HIV seropositivity. Studies indicate that men with a diagnosis of AIDS or HIV seropositivity have up to 36 times greater risk of suicide than men without the diagnosis. Yet few studies controlled for independent risk factors such as premorbid or comorbid p
Primary pulmonary hypertension or portopulmonary hypertension? [letter]: Chest. 1998 Oct;114(4):1224-5. Unique Identifier : AIDSLINE MED/99007090; Gossage JR
Evaluation of screening kits for the detection of anti-human immunodeficiency virus type 1 and 2 (HIV-1/2) antibodies.: Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1995 Aug;28(3):179-92. Unique Identifier : AIDSLINE MED/98448123; Chin LT; Yang BS; Chen JW; Yang CM; Chou CC; Li L; Hung CM; Tsai SJ; Lin KS; Chinese Blood Services Foundation (CBSF), Taipei, Taiwan, R.O.C.; HIV-1/HIV-2 3rd generation (Abbott), Wellcozyme HIV 1 + 2 (Murex), Enzygnost Anti-HIV 1/-HIV 2 (Behring), and Genelavia Mixt (Sanofi Diagnostics Pasteur) are currently registered by authorities as enzyme immunoassays (EIAs) for detecting HIV-1/2 infection. The present study dissects these reagents by means of the majo
[RKI "Current version of prophylactic drug therapy after occupational HIV-exposure". Consensus conference 21 November 1997 in Munich]: Chirurg. 1998 Jul;69(7):suppl 224-6. Unique Identifier : AIDSLINE MED/98409967
Recovery from life-threatening, corticosteroid-unresponsive, chemotherapy-related reactivation of hepatitis B associated with lamivudine therapy.: Dig Dis Sci. 1998 Oct;43(10):2267-70. Unique Identifier : AIDSLINE MED/99005124; ter Borg F; Smorenburg S; de Man RA; Rietbroek RC; Chamuleau RA; Jones EA; Department of Gastrointestinal and Liver Diseases, Academic; Medical Center, University of Amsterdam, The Netherlands.; Although exacerbations of previously quiescent HBV infection, associated with chemotherapy, have been attributed to enhanced immunological responses to hepatocytes harboring reactivated HBV, the recommended treatment, prednisolone, is often unsuccessful. A young HBsAg-positive, anti-HBe-positive carrier, who received
Mycobacterium kansasii osteomyelitis presenting as a solitary lytic lesion of the ulna: fine-needle aspiration findings and morphologic comparison with other mycobacteria.: Diagn Cytopathol. 1998 Aug;19(2):94-7. Unique Identifier : AIDSLINE MED/98367860; Schnadig VJ; Quadri SF; Boyvat F; Borucki M; Department of Pathology, University of Texas Medical Branch,; Galveston 77555-0548, USA.; A 35-yr-old woman, with acquired immunodeficiency syndrome, presented with right arm pain, erythema, and swelling. A lytic lesion of the ulna was found by radiograph. Ultrasonic and fluoroscopic guided fine-needle aspiration (FNA) yielded a neutrophilic and histiocytic exudate admixed with abundant long, bacillary for
Multivesiculated macrophages: their implication in fine-needle aspiration cytology of lung mass lesions.: Diagn Cytopathol. 1998 Aug;19(2):98-101. Unique Identifier : AIDSLINE MED/98367861; Reyes CV; Thompson KS; Jensen J; Cytology Section, Veterans Affairs Hospital, Hines, Illinois,; USA.; Alveolar macrophages are almost invariably present in percutaneous fine-needle aspiration cytology of the lung. They may predominate, appear foamy and finely vesiculated, or may reflect the cellular composition of the lung mass lesion. In a review of 172 cases of negative for malignant cells from the percutaneous lu
Cytologic features of mycobacterial pleuritis: logistic regression and statistical analysis of a blinded, case-controlled study.: Diagn Cytopathol. 1998 Sep;19(3):173-6. Unique Identifier : AIDSLINE MED/98413423; Ellison E; Lapuerta P; Martin SE; Department of Pathology, University of Southern California, Los; Angeles 90033, USA.; Tuberculous pleural effusions are characterized by lymphocytosis; the significance of mesothelial cells is uncertain, as are the cytologic features in concurrent human immunodeficiency virus (HIV) infection. This blinded study compared 38 culture-positive pleural fluids (6 HIV+) with 38 controls from benign exudative
Human immunodeficiency virus infection, Part I.: Dis Mon. 1998 Oct;44(10):545-606. Unique Identifier : AIDSLINE MED/99031910; Horowitz HW; Telzak EE; Sepkowitz KA; Wormser GP; Department of Medicine, New York Medical College, Valhalla, USA.; Initially recognized in 1982, acquired immunodeficiency syndrome (AIDS) has been the leading cause of death among young adults in the United States for much of this decade, and it has had a devastating impact on people in the developing world. It is estimated that 42 million people wor
Determination of mRNA expression for IFN-gamma and IL-4 in lymphocytes from children with IDDM by RT-PCR technique.: Diabetes Res Clin Pract. 1998 Apr;40(1):21-30. Unique Identifier : AIDSLINE MED/98364243; Karlsson MG; Ludvigsson J; Department of Health and Environment, Faculty of Health Sciences,; University Hospital, Linkoping, Sweden.; maria.karlsson@kfc.liu.se; Insulin-dependent diabetes mellitus (IDDM) is characterized by infiltration of T-lymphocytes in the islets of Langerhans. Antigens are presented to Th-lymphocytes which can be divided into Th1- and Th2-lymphocytes, producing interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) respectively. The aim of our study was t
Absorption, distribution, metabolism, and excretion of atevirdine in the rat.: Drug Metab Dispos. 1998 Oct;26(10):1008-18. Unique Identifier : AIDSLINE MED/98437307; Chang M; Sood VK; Wilson GJ; Kloosterman DA; Sanders PE; Schuette MR; Judy RW; Voorman RL; Maio SM; Slatter JG; Drug Metabolism and Disposition Research, Analytical and; Medicinal Chemistry, Pharmacia & Upjohn, Inc., Kalamazoo, MI; 49007, USA.; Atevirdine mesylate (U-87201E) is a highly specific nonnucleoside inhibitor of human immunodeficiency virus type 1 reverse transcriptase. The absorption, metabolism, and excretion of atevirdine were investigated in male and female Sprague-Dawley rats after oral administration of nonradiolabeled atevirdine mesylate at
[New trends in HIV (news)]: Dtsch Med Wochenschr. 1998 Sep 18;123(38):A7. Unique Identifier : AIDSLINE MED/99003555; Volkert R
[First phase-III HIV vaccines: a chance or too early? (news)]: Dtsch Med Wochenschr. 1998 Sep 18;123(38):A7-9. Unique Identifier : AIDSLINE MED/99003556; Schenk M
[Vertical transmission: healthy children--a new UNAIDS initiative (news)]: Dtsch Med Wochenschr. 1998 Sep 18;123(38):A9. Unique Identifier : AIDSLINE MED/99003557; Volkert R
Contemporary treatment of tuberculosis in HIV prevalent countries in sub-Saharan Africa.: East Afr Med J. 1998 Jun;75(6):358-63. Unique Identifier : AIDSLINE MED/99020462; Nuwaha F; Department of Community Health, Mbarara University, Uganda.; The HIV pandemic has been worst felt in sub-Saharan Africa. Tuberculosis is an opportunistic disease in the course of HIV infection and in the region, where the prevalence of both M. tuberculosis and HIV are very high, tuberculosis has become a major complication of HIV infection. The annual risk of tuberculosis infec
Management of Fournier's gangrene at the Kenyatta National Hospital, Nairobi.: East Afr Med J. 1998 Jun;75(6):370-3. Unique Identifier : AIDSLINE MED/99020464; Ayumba BR; Magoha GA; Department of Surgery, Faculty of Health Sciences, Moi; University, Eldoret.; A prospective study involving the management of forty six patients with Fournier s gangrene was carried out at the Kenyatta National Hospital, Nairobi over a period of two years. The age range was nine to 81 years with a mean of 40.27 years indicating that the lesion is common and affects all age groups in this locali
Herpes zoster in HIV/AIDS--a little recognised opportunistic infection with important clinical and cost implications [editorial; comment]: East Afr Med J. 1998 Jul;75(7):377-8. Unique Identifier : AIDSLINE MED/99020466; McLigeyo SO
Significance of herpes zoster in HIV/AIDS in Kweneng district, Botswana [see comments]: East Afr Med J. 1998 Jul;75(7):379-81. Unique Identifier : AIDSLINE MED/99020467; Edhonu-Elyetu Y; OBJECTIVE: To determine the relevance of herpes zoster eruption or scar relative to other symptoms and signs of HIV/AIDS and to look for a syndromic model that could be used in the diagnosis of HIV infection. DESIGN: Retrospective case-control study on data from the results of HIV request forms in the district from 1s
Disseminated aspergillus fumigatus infection: case report.: East Afr Med J. 1998 Jul;75(7):436-8. Unique Identifier : AIDSLINE MED/99020480; Orem J; Mpanga L; Habyara E; Nambuya A; Aisu T; Wamukota W; Otim MA; Medical Research Council, Uganda Virus Research Institute,; Entebbe, Uganda.; A case of disseminated aspergillus fumigatus infection is reported in a 43 year old Ugandan female with no known immune system disorder(not neutropenic and HIV-1 sero negative). She presented with multiple cutaneous ulcers, recurrent empyema thoracis, a past history of intra-abdominal abscess and bowel infarction. Emp
Behavioral research on AIDS--protease inhibitors and the new millennium: comment on Kelly, Otto-Salaj, Sikkema, Pinkerton, and Bloom (1998).: Health Psychol. 1998 Jul;17(4):307-9. Unique Identifier : AIDSLINE MED/98361404; Ferrando S; The New York Hospital-Cornell University Medical College, New; York 10021, USA. sjferran@mail.med.cornell.edu; The use of combination antiretroviral therapy in conjunction with the clinical use of viral load measurements have contributed to the resurrection of thousands of individuals who were expected to be on a downward spiral with symptomatic HIV/AIDS. In this context, those living with HIV face a host of new challenges,
Implications of HIV treatment advances for behavioral research on AIDS: protease inhibitors and new challenges in HIV secondary prevention.: Health Psychol. 1998 Jul;17(4):310-9. Unique Identifier : AIDSLINE MED/98361405; Kelly JA; Otto-Salaj LL; Sikkema KJ; Pinkerton SD; Bloom FR; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53226, USA.; Protease inhibitor combination therapies can reduce HIV viral load, improve immune system functioning, and decrease mortality from AIDS. These medical developments raise a host of critical new issues for behavioral research on HIV/AIDS. This article reviews developments in HIV
Risk for HIV infection among bisexual men seeking HIV-prevention services and risks posed to their female partners.: Health Psychol. 1998 Jul;17(4):320-7. Unique Identifier : AIDSLINE MED/98361406; Kalichman SC; Roffman RA; Picciano JF; Bolan M; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53226, USA. sethk@mcw.edu; The present study interviewed gay (n = 473) and bisexual men (n = 146) as part of an HIV prevention program and investigated social cognitive factors associated with HIV risk. Results indicated that HIV risk in homosexual men was associated with sexual openness and connections to gay communities, factors not associate
Reinforcement value of unsafe sex as a predictor of condom use and continued HIV/AIDS risk behavior among gay and bisexual men.: Health Psychol. 1998 Jul;17(4):328-35. Unique Identifier : AIDSLINE MED/98361407; Kelly JA; Kalichman SC; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53226, USA.; The pleasure or reinforcement value of high-risk sex may be an important influence on success in risk reduction efforts. Seronegative gay and bisexual men (N = 297) completed measures assessing their unprotected and safer sex practices, as well as measures of cognitive and skill factors and a measure assessing the sub
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.: EMBO J. 1998 Sep 15;17(18):5321-33. Unique Identifier : AIDSLINE MED/98409537; Schwaller J; Frantsve J; Aster J; Williams IR; Tomasson MH; Ross TS; Peeters P; Van Rompaey L; Van Etten RA; Ilaria R Jr; Marynen P; Gilliland DG; Division of Hematology and Oncology, Harvard Medical School,; Boston, MA 02115, USA.; Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the TEL pointed (PNT) domain to (i) the JAK2 JH1-kinase domain, (ii) part of and (iii) all of the JH2 pseudokinase domain. We report that all of the human TEL/JAK2
Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.: EMBO J. 1998 Oct 1;17(19):5832-43. Unique Identifier : AIDSLINE MED/98429506; Esposito D; Craigie R; Laboratory of Molecular Biology, NIDDK, National Institutes of; Health, 5 Center Drive MSC0560, Bethesda, MD 20892, USA.; HIV-1 integrase specifically recognizes and cleaves viral end DNA during the initial step of retroviral integration. The protein and DNA determinants of the specificity of viral end DNA binding have not been clearly identified. We have used mutational analysis of the viral end LTR sequence, in vitro selection of optim
Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1.: Eur J Biochem. 1998 Sep 1;256(2):334-41. Unique Identifier : AIDSLINE MED/98430972; de Marco A; Carattoli A; Rozera C; Fortini D; Giorgi C; Belardo G; Amici C; Santoro MG; Department of Biology, University of Rome Tor Vergata, Italy.; Cyclopentenone prostaglandins inhibit the replication of several DNA and RNA viruses, including retroviruses. The antiviral activity has been associated with the induction of a 70-kDa heat-shock protein (HSP70), via activation of the heat-shock transcription factor (HSF) in infected cells. In the present study we inve
Solution structures of human immunodeficiency virus type 1 (HIV-1) and moloney murine leukemia virus (MoMLV) capsid protein major-homology-region peptide analogs by NMR spectroscopy.: Eur J Biochem. 1998 Oct 1;257(1):69-77. Unique Identifier : AIDSLINE MED/99013448; Clish CB; Peyton DH; Barklis E; Department of Chemistry, Portland State University, Oregon; 97207-0751, USA.; The capsid domain of retroviral Gag proteins possesses a single highly conserved subdomain termed the major homology region (MHR). While the mutagenesis of residues in the MHR will impair virus infectivity, the precise solution structure and function of the MHR is not known. To aid the structure/function characterizat
Human immunodeficiency virus mutation and changes in CD4 T-cell levels during antiretroviral therapy [editorial]: Eur J Clin Microbiol Infect Dis. 1998 May;17(5):301-3. Unique Identifier : AIDSLINE MED/98387411; Battegay M
Brucellosis in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1998 May;17(5):319-26. Unique Identifier : AIDSLINE MED/98387415; Moreno S; Ariza J; Espinosa FJ; Podzamczer D; Miro JM; Rivero A; Rodriguez-Zapata M; Arrizabalaga J; Mateos R; Herrero F; Department of Clinical Microbiology, Hospital General; Universitario J.Ma Morales Meseguer, Murcia, Spain.; Brucellosis has been described rarely in patients infected with HIV, despite the fact that eradication of intracellular brucellae is largely dependent on cell-mediated immunity. The characteristics of all patients with HIV infection and brucellosis seen in seven Spanish hospitals are reported. Since the beginning of t
Itraconazole as maintenance therapy for visceral leishmaniasis in HIV-infected patients.: Eur J Clin Microbiol Infect Dis. 1998 May;17(5):365-7. Unique Identifier : AIDSLINE MED/98387426; Angarano G; Maggi P; Coppola SL; Cavaliere RL; Department of Infectious Diseases, University of; Bari-Policlinico, Italy.
High prevalence of hepatitis C virus genotype 6 among certain risk groups in Hong Kong.: Eur J Epidemiol. 1998 Jul;14(5):421-6. Unique Identifier : AIDSLINE MED/98415921; Wong DA; Tong LK; Lim W; Government Virus Unit, Queen Mary Hospital, Pokfulam, Hong Kong.; The genotype of hepatitis C virus (HCV) of 172 HCV-RNA positive serum specimens taken from patients with chronic liver diseases, thalassaemia major, chronic renal failure (CRF), haemophilia and intravenous drug abusers (IVDA) was determined by analysis of the amplified 5 UTR region by genotype-specific oligonucleotide
The impact of the 1993 European revision of the AIDS case definition on back-calculation estimates: an application in Italy.: Eur J Epidemiol. 1998 Jul;14(5):427-32. Unique Identifier : AIDSLINE MED/98415922; Verdecchia A; Grossi P; Cantoni M; Laboratory of Epidemiology and Biostatistics, Istituto Superiore; di Sanita, Rome, Italy.; OBJECTIVES: The revision of the case definition for AIDS within a given observation period causes discontinuity points on the epidemic curve to which back-calculation procedures can be sensitive. The aim of this work is to characterize the impact of the 1993 European revision of AIDS case definition and to evaluate th
Temporal trends in reasons for and result of HIV-testing among women in Rome, Italy.: Eur J Epidemiol. 1998 Jul;14(5):433-7. Unique Identifier : AIDSLINE MED/98415923; Puro V; D'Ubaldo C; Aloisi MS; Sherr L; Ippolito G; I.R.C.C.S. Lazzaro Spallanzani, Centro di Riferimento AIDS e; Servizio di Epidemiologia delle Malattie Infettive, Rome, Italy.; To describe the trend in the reasons for and result of women s HIV testing, systematic data was gathered for 11,523 consecutive women during pre-and post-test visits at a major counseling and testing (CT) site of Rome, Italy , June 1985-July 1996. The number of tested women and the p
Newly diagnosed HIV infections among pregnant women and their partners [letter]: Eur J Epidemiol. 1998 Jul;14(5):521-2. Unique Identifier : AIDSLINE MED/98415937; Puro V; Ippolito G
Pseudomonas aeruginosa bronchopulmonary infection in patients with AIDS, with emphasis on relapsing infection.: Eur Respir J. 1998 Jul;12(1):107-12. Unique Identifier : AIDSLINE MED/98365153; Domingo P; Ferre A; Baraldes MA; Ris J; Sanchez F; Dept of Internal Medicine, Hospital de la Santa Creu i Sant Pau,; Universitat Autonoma de Barcelona, Spain.; The aim of this study was to delineate the clinical and therapeutic characteristics of Pseudomonas aeruginosa bronchopulmonary infection in acquired immunodeficiency syndrome (AIDS) patients. Eighteen AIDS patients had 39 episodes of P. aeruginosa bronchopulmonary infection. Their mean CD4 cell count was 0.012+/-0.011
Influence of antimicrobial chemotherapy on spirometric parameters and pro-inflammatory indices in severe pulmonary tuberculosis.: Eur Respir J. 1998 Aug;12(2):351-6. Unique Identifier : AIDSLINE MED/98394767; Plit ML; Anderson R; Van Rensburg CE; Page-Shipp L; Blott JA; Fresen JL; Feldman C; Dept of Immunology, Institute for Pathology, University of; Pretoria, South Africa.; Patients who have completed a treatment for severe pulmonary tuberculosis (TB) are often left with severe respiratory disability. There have been few prospective studies assessing the effect of treatment on lung function in such patients. The influence of antimicrobial chemotherapy on lung function was investigated ov
Sequence specific cleavage of the HIV-1 coreceptor CCR5 gene by a hammer-head ribozyme and a DNA-enzyme: inhibition of the coreceptor function by DNA-enzyme.: FEBS Lett. 1998 Oct 2;436(2):233-8. Unique Identifier : AIDSLINE MED/98452945; Goila R; Banerjea AC; Laboratory of Virology, National Institute of Immunology, Aruna; Asaf Ali Marg, New Delhi, India.; The chemokine receptor CCR5 is used as a major coreceptor for fusion and entry by non-syncytia inducing macrophage tropic isolates of HIV-1, which is mainly involved in transmission. Individuals who are homozygous for the delta32 allele of CCR5 are usually resistant to HIV-1 infection and continue to lead a normal hea
In vivo phosphorylation of poly(ADP-ribose) polymerase is independent of its activation.: FEBS Lett. 1998 Oct 2;436(2):288-92. Unique Identifier : AIDSLINE MED/98452957; Ariumi Y; Ueda K; Masutani M; Copeland TD; Noda M; Hatanaka M; Shimotohno K; Institute for Virus Research, Kyoto University, Japan.; ariumi@virus.kyoto-u.ac.jp; Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme, which is activated by DNA strand breaks. Although PARP is known to be cleaved by the cysteine protease, caspase-3/CPP32, during apoptosis, signal cascade which regulates the PARP activity has not been fully understood. In this study, we investigated post-translat
HIV/gp120 and PMA/ionomycin induced apoptosis but not activation induced cell death require PKC for Fas-L upregulation.: FEBS Lett. 1998 Oct 9;436(3):461-5. Unique Identifier : AIDSLINE MED/99015788; Accornero P; Radrizzani M; Care A; Mattia G; Chiodoni C; Kurrle R; Colombo MP; Division of Experimental Oncology D, Istituto Nazionale Tumori,; Milan, Italy.; HIV protein gp120 in combination with T cell antigen receptor (TCR) triggering induces apoptosis (gp120-apoptosis) in Th1 cells. Gp120-apoptosis occurs by induction of Fas-L and subsequent triggering of the Fas apoptotic pathway. Here, through the use of several compounds inhibiting induction of Fas-L, we show that, i
Screening infertile couples for HIV infection [letter]: Fertil Steril. 1998 Oct;70(4):785-6. Unique Identifier : AIDSLINE MED/99011144; Abusheikha N; Akagbosu F; Marcus S; Lass A; Cousins C; Brinsden P
Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection.: FASEB J. 1998 Nov;12(14):1473-80. Unique Identifier : AIDSLINE MED/99024076; Juompan L; Lambin P; Zouali M; Departement d'Immunologie, Institut Pasteur, 75015 Paris,; France.; HIV infection is characterized by accelerated apoptosis and progressive loss of B cells. To see whether these abnormalities are related to the property of gp120 to act as a superantigen for VH3(+) B cells, we probed the temporal development of VH3(+) antibodies in HIV-1-infected subjects over a 7-year period. We found
[Adult multi-nuclear cell hepatitis. A study in 17 patients]: Gastroenterol Clin Biol. 1998 Mar;22(3):305-10. Unique Identifier : AIDSLINE MED/98434964; Tordjmann T; Grimbert S; Genestie C; Freymuth F; Guettier C; Callard P; Trinchet JC; Beaugrand M; Service d'Hepato-Gastroenterologie, Hopital Jean-Verdier,; Bondy.; OBJECTIVES: Giant-cell hepatitis is rare in adults and its significance has not been clarified. We report the clinical and histological characteristics and outcome in a group of adult patients with giant-cell hepatitis. METHODS: Seventeen patients with giant-cell hepatitis, hospitalized in our unit between 1976 and 19
[Epidemiology of hepatitis C virus infection in 1,304 HCV positive patients: variations according to the origin of transmission and year of diagnosis]: Gastroenterol Clin Biol. 1998 Apr;22(4):375-80. Unique Identifier : AIDSLINE MED/98435014; Guyader D; Lefeuvre C; Jacquelinet S; Prat M; Baudouard Y; Turlin B; Andre P; Mendler MH; Sapey T; Boucher E; Moirand R; Messner M; Colimon R; Brissot P; Deugnier Y; Clinique des Maladies du Foie et Inserm U49, Centre Hospitalier; Universitaire Pontchaillou, Rennes.; The evolution of epidemiological data on hepatitis C virus infection is poorly documented and thus the impact of screening is difficult to evaluate. AIM: To study epidemiological variations based on the origin of transmission and the year of diagnosis of hepatitis C virus infection. METHODS: The files of all 1304 pati
[A 1993-1995 epidemiological survey of home parenteral nutrition in approved centers for adults in France]: Gastroenterol Clin Biol. 1998 Apr;22(4):413-8. Unique Identifier : AIDSLINE MED/98435019; Messing B; Barnoud D; Beau P; Bornet JL; Chambrier C; Constanzo JD; Gerard-Boncompain M; Guedon C; Hebuterne X; Heresbach D; de Ledinghen V; Lescut D; Reimund JM; Senesse P; Beliah M; Bouletreau P; Bretagne JF; Descos L; Duclos B; Kerjean A; Lerebours E; Leverve X; Morichau-Beauchant M; Paris JC; Rampal P; et al; Service d'Hepato-Gastroenterologie, Hopital Saint-Lazare,; Paris.; OBJECTIVES: A 1993-1995 three year epidemiological survey of home parenteral nutrition was performed through in France in approved centers for adults. METHODS: Data were retrospectively collected each year on a standardized questionnaire focussing on indications and short term outc
The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.: Genes Dev. 1998 Oct 1;12(19):2992-6. Unique Identifier : AIDSLINE MED/98438446; Li XY; Green MR; Howard Hughes Medical Institute, Program in Molecular Medicine,; University of Massachusetts Medical Center, Worcester,; Massachusetts 01605, USA.; The human immunodeficiency virus type 1 (HIV-1) Tat protein strongly and specifically stimulates transcription elongation from the HIV-1 LTR and provides an important in vitro model system to study this process. Here we use protein-affinity chromatography to identify cellular factors involved in transcription elongati
Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.: Genes Dev. 1998 Oct 1;12(19):3137-43. Unique Identifier : AIDSLINE MED/98438458; Johnson RE; Torres-Ramos CA; Izumi T; Mitra S; Prakash S; Prakash L; Sealy Center for Molecular Science, University of Texas Medical; Branch, Galveston, Texas 77555-1061, USA.; Abasic (AP) sites arise in DNA through spontaneous base loss and enzymatic removal of damaged bases. APN1 encodes the major AP-endonuclease of Saccharomyces cerevisiae. Human HAP1 (REF1) encodes the major AP endonuclease which, in addition to its role in DNA repair, functions as a redox regulatory protein. We identify
AIDS protection and contraception among African American, Hispanic, and white women.: Health Soc Work. 1998 Aug;23(3):186-94. Unique Identifier : AIDSLINE MED/98367927; Hines AM; Graves KL; College of Social Work, San Jose State University, CA 95192-0124,; USA. hines@email.sjsu.edu; The goal of this study was to examine behaviors related to AIDS protection and contraception among African American, Hispanic, and white women. Data were collected in 1991 and 1992 as part of a large-scale National Alcohol Survey in which respondents were asked questions about AIDS-related sexual behavior and attitude
[Cryptosporidiosis and microsporidiosis in immune deficiency]: Fortschr Med. 1998 Jul 20;116(20-21):29-31. Unique Identifier : AIDSLINE MED/98410082; Petry F; Gross U
[Non-nucleoside reverse transcriptase inhibitors. AIDS long-term management]: Fortschr Med. 1998 Jul 20;116(20-21):56-7. Unique Identifier : AIDSLINE MED/98410088; Sautter R
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism [see comments]: Hepatology. 1998 Oct;28(4):906-13. Unique Identifier : AIDSLINE MED/98429547; Chen XM; Levine SA; Tietz P; Krueger E; McNiven MA; Jefferson DM; Mahle M; LaRusso NF; Center for Basic Research in Digestive Diseases, Division of; Gastroenterology and Internal Medicine, Rochester, MN 55905, USA.; While the clinical features of sclerosing cholangitis secondary to opportunistic infections of the biliary tree in patients with acquired immunodeficiency syndrome (AIDS) are well known, the mechanisms by which microbial pathogens such as Cryptosporidium parvum associated with this syndrome actually cause disease are
Search for hepatitis C virus extrahepatic replication sites in patients with acquired immunodeficiency syndrome: specific detection of negative-strand viral RNA in various tissues.: Hepatology. 1998 Nov;28(5):1398-401. Unique Identifier : AIDSLINE MED/99013913; Laskus T; Radkowski M; Wang LF; Vargas H; Rakela J; Division of Transplantation Medicine, Thomas E. Starzl; Transplantation Institute, University of Pittsburgh, Pittsburgh,; PA, USA.; The existence of extrahepatic reservoirs of hepatitis C virus (HCV) replication remains highly controversial. We searched for the presence of HCV-RNA negative strand in various tissues from eight HCV-infected patients who died of acquired immunodeficiency syndrome (AIDS)-related complications. Negative-strand RNA was
Kaposi's sarcoma-associated herpesvirus in Kikuchi's disease.: Hum Pathol. 1998 Oct;29(10):1091-6. Unique Identifier : AIDSLINE MED/98452907; Huh J; Kang GH; Gong G; Kim SS; Ro JY; Kim CW; Department of Pathology, Asan Medical Center, Ulsan University,; College of Medicine, Seoul, Korea.; Kikuchi s disease is a fairly common self-limited disorder among Orientals that usually involves the cervical lymph nodes of young individuals and occurs predominantly in females. Frequently, the disease is associated with fever or flu-like symptoms, an elevated erythrocyte sedimentation rate (ESR), neutropenia, and l
Molecular pathological analysis of testicular diffuse large cell lymphomas.: Hum Pathol. 1998 Nov;29(11):1231-9. Unique Identifier : AIDSLINE MED/99039706; Hyland J; Lasota J; Jasinski M; Petersen RO; Nordling S; Miettinen M; Armed Forces Institute of Pathology, Department of Soft Tissue; Pathology, Washington, DC 20306-6000, USA.; The molecular pathology of 20 lymphomas, which presented as testicular masses in patients with no evidence of previous lymphoma, was analyzed. These lymphomas occurred in men with a median age of 69 years (range, 37 to 87 years). Nine of the 14 patients with follow-up died of lymphoma (median survival, 12 months). All
HIV-associated malignant lymphomas in Kenya (Equatorial Africa).: Hum Pathol. 1998 Nov;29(11):1285-9. Unique Identifier : AIDSLINE MED/99039714; Lazzi S; Ferrari F; Nyongo A; Palummo N; de Milito A; Zazzi M; Leoncini L; Luzi P; Tosi P; Institute of Pathologic Anatomy and Histology, University of; Siena, Italy.; The clinical and pathological features of acquired immune deficiency syndrome (AIDS)-related lymphomas, including their relationship with other viruses, such as Epstein-Barr virus (EBV) and human herpes virus-8 (HHV8), have been the subject of several studies from North America and Europe. No consistent data have been
Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.: Immunol Rev. 1998 Jun;163:197-215. Unique Identifier : AIDSLINE MED/98365869; Wang J; Springer TA; Dana-Farber Cancer Institute, Harvard Medical School, Boston,; Massachussetts, USA.; The circulation and migration of leukocytes are critical for immune surveillance and immune response to infection or injury. The key step of leukocyte recruitment involves the adhesion between immunoglobulin superfamily (IgSF) proteins on endothelium and integrin molecules on leukocyte surfaces. Some of the IgSF membe
Pathology of the heart in acquired immunodeficiency syndrome.: Indian Heart J. 1998 May-Jun;50(3):321-5. Unique Identifier : AIDSLINE MED/98426464; Lanjewar DN; Katdare GA; Jain PP; Hira SK; Department of Pathology, Grant Medical College amd Sir JJ Group; of Hospitals, Mumbai.; The spectrum of cardiac lesions in patients with acquired immunodeficiency syndrome in India is not described. To determine the extent of involvement of the heart with this disease, an autopsy study of 52 subjects having acquired immunodeficiency syndrome was carried out. Multiple s
An investigation of the conformation of peptide-T and its D-Ala analog by NMR and molecular dynamics simulations.: Indian J Biochem Biophys. 1998 Jun;35(3):133-41. Unique Identifier : AIDSLINE MED/99020502; Ojha RP; Saran A; Kamath S; Coutinho E; Physics Department, Gorakhpur University.; Peptide-T (ASTTTNYT) and its D-Ala analog (D-ASTTTNYT-NH2) have been designed to block the adsorption of HIV to CD4 receptors on T-cell lymphocytes, thus inhibiting viral infectivity. The conformation of these important peptides has been investigated by 2D-NMR and molecular dynamics simulations. The NMR studies in DMS
Urokinase plasminogen activator receptor (uPAR; CD87) expression on monocytic cells and T cells is modulated by HIV-1 infection.: Immunobiology. 1998 Jul;199(1):152-62. Unique Identifier : AIDSLINE MED/98383420; Speth C; Pichler I; Stockl G; Mair M; Dierich MP; Institute of Hygiene, University of Innsbruck, Austria.; cornelia.speth@uibk.ac.at; The transmembranous urokinase-type plasminogen activator receptor (uPAR; CD87) focuses the formation of active plasmin at the cell surface, thus enhancing directional extracellular proteolysis. Since proteolysis is involved in processes like adhesion, chemotaxis and migration which are important for viral spreading, w
Skewed TCRV beta repertoire in human thymus persists after thymic emigration: influence of genomic imposition, thymic maturation and environmental challenge on human TCRV beta usage in vivo.: Immunobiology. 1998 Jul;199(1):74-86. Unique Identifier : AIDSLINE MED/98383414; Reinhardt C; Melms A; Department of Neurology, University of Tubingen, Germany.; In order to investigate the mechanisms involved in originating a diverse TCR repertoire in human peripheral blood we analyzed TCRV beta surface expression in different T cell subsets of unrelated individuals. The relative frequencies of 11 distinct V beta chains were determined for immature double positive (DP) as wel
Down modulation of MHC surface molecules on B cells by suppressive immune complexes obtained from chronic intestinal schistosomiasis patients.: Immunol Lett. 1998 Jun;62(2):67-73. Unique Identifier : AIDSLINE MED/98361566; Rezende SA; Gollob KJ; Correa-Oliveira R; Goes AM; Departamento de Bioquimica-Immunologia, Instituto de Ciencias; Biologicas, Universidade Federal de Minas Gerais, Belo; Horizonte, Brazil.; Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role
Antigenic characterization of HIV-1 gp41 binding proteins.: Immunol Lett. 1998 Jun;62(2):75-9. Unique Identifier : AIDSLINE MED/98361567; Chen YH; Speth C; Wu W; Stockl G; Xiao Y; Yu T; Ke Z; Zhao Y; Dierich MP; Department of Biological Sciences and Biotechnology, Tsinghua; University, Beijing, People's Republic of China.; The envelope protein HIV-1 gp41 has been shown to exert various effects on human T-cells, B-cells and monocytes like inhibition of cell proliferation, modulation of MHC expression and cytokine production. In contrast to gpl20, where several receptor molecules have been identified, the receptor for gp41 is still unknow
Binding of feline immunodeficiency viral gag-p24 polypeptide to nonimmune Igs.: Immunol Lett. 1998 Jun;62(2):93-7. Unique Identifier : AIDSLINE MED/98361570; Amici A; Smorlesi A; Concetti A; Ripani E; Battistini L; Venanzi FM; Department of Biology MCA, University of Camerino, MC, Italy.; Available data on the existence of lentivirus proteins with properties of unconventional Ag for B cells, have been so far restricted to human immunodeficiency virus (i.e. gp-120 of HIV-I). By using biotinylated-MAbs-anti-biotin IgG as readout system, we now report that gag-p24 antigen, either assembled in feline immun
Cotrimoxazole induced toxic epidermal necrolysis in a suspected case of Pneumocystis carinii pneumonia with human immuno deficiency virus infection.: Indian J Chest Dis Allied Sci. 1998 Apr-Jun;40(2):125-9. Unique Identifier : AIDSLINE MED/98448709; Arora VK; Venubabu K; Department of Tuberculosis and Chest Diseases, J.I.P.M.E.R.,; Hospital, Pondicherry.; Toxic epidermal necrolysis due to trimethoprim sulphamethoxazole therapy in a subject of HIV with suspected pneumocystis carinii pneumonia, is reported, because of its rarity in Indian conditions. Patient showed excellent recovery on corticosteroid therapy.
Evaluation of the BACTEC radiometric method in the early diagnosis of tuberculosis.: Indian J Med Res. 1998 Oct;108:120-7. Unique Identifier : AIDSLINE MED/99022682; Venkataraman P; Herbert D; Paramasivan CN; Tuberculosis Research Centre (ICMR), Chennai.; A comparison of the BACTEC radiometric method with the conventional culture and drug susceptibility testing methods on isolates from clinical specimens in pulmonary and extrapulmonary tuberculosis, childhood TB and TB in HIV-infected individuals was undertaken. In the case of pulmonary TB, the rate of isolation of pos
Cross-reactive HIV-1-specific CTL in recent seroconverters from Pune, India.: Indian J Med Res. 1998 Aug;108:35-41. Unique Identifier : AIDSLINE MED/99001855; Paranjape RS; Gadkari DA; Lubaki M; Quinn TC; Bollinger RC; National AIDS Research Institute, Pune.; In the light of the diversity of HIV, matching the genotype of candidate HIV vaccines with the transmitted genotype may be required. Alternatively, matching the immunotype of HIV vaccines and transmitted subtypes may be the best option. Since studies of cross-subtype HIV-1 immunity are limited, subtype B specific cyto
Increasing prevalence of HIV antibody among blood donors monitored over 9 years in one blood bank.: Indian J Med Res. 1998 Aug;108:42-4. Unique Identifier : AIDSLINE MED/99001856; Rose D; Sudarsanam A; Padankatti T; Babu PG; John TJ; John Scudder Memorial Blood Bank, Department of Clinical; Pathology, Christian Medical College & Hospital, Vellore.; To determine the time trend of HIV infection among non-professional blood donors at the Christian Medical College and Hospital, Vellore, the annual HIV prevalence among them for the years 1993-1997 was compared with that of the previous 5 yr. Since confirmed number of HIV positive blood donors is required for calculat
Incidence of HIV infection & its predictors in blood donors in Delhi.: Indian J Med Res. 1998 Aug;108:45-50. Unique Identifier : AIDSLINE MED/99001857; Kapur S; Mittal A; Institute of Pathology (ICMR), New Delhi.; The concurrence of human immunodeficiency virus (HIV) infection with hepatitis B virus (HBV) and syphilis and the trend that these infections have followed in blood donors during the last eight years from 1989 to 1997 were studied at a Zonal Blood Testing Centre in New Delhi. Overall, HIV was positive in 0.068 per cen
Clinical features & HIV progression as observed longitudinally in a cohort of injecting drug users in Manipur.: Indian J Med Res. 1998 Aug;108:51-7. Unique Identifier : AIDSLINE MED/99001858; Agarwal AK; Singh NY; Devi LB; Shyamkanhai KH; Singh YM; Bhattacharya SK; ICMR Project on HIV/AIDS & Substance Abuse, Calcutta.; Study on a cohort of injecting drug users (n = 76) was initiated in June, 1994 with the objective of documenting the clinical presentation of HIV and its progression with time. The participation in the study was voluntary. An informed consent was taken from the subjects before they were enrolled in the study. The subj
Cytotoxic T-lymphocyte-mediated lysis of Toxoplasma gondii-infected target cells does not lead to death of intracellular parasites.: Infect Immun. 1998 Oct;66(10):4651-5. Unique Identifier : AIDSLINE MED/98427126; Yamashita K; Yui K; Ueda M; Yano A; Department of Medical Zoology, Nagasaki University School of; Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan.; CD8(+) T cells play a crucial role in the control of infection with intracellular microbes. The mechanisms underlying the CD8(+) T-cell-mediated clearance of the intracellular pathogen Toxoplasma gondii are, however, not completely understood. The effect of CD8(+) cytotoxic T-lymphocyte (CTL)-mediated lysis of host ce
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans.: Infect Immun. 1998 Oct;66(10):4994-5000. Unique Identifier : AIDSLINE MED/98427174; Decken K; Kohler G; Palmer-Lehmann K; Wunderlin A; Mattner F; Magram J; Gately MK; Alber G; Department of Infectious Diseases, F. Hoffmann-La Roche AG,; Basel, Switzerland.; To analyze the roles of interleukin-12 (IL-12) and the IL-12-dependent Th1 response in resistance to Cryptococcus neoformans, we have established a chronic infection model in wild-type mice and in mice with targeted disruptions of the genes for the IL-12p35 and IL-12p40 subunits (IL-12p35(-/-) and IL-12p40(-/-) mice,
CD95 expression in aged mice infected with tuberculosis.: Infect Immun. 1998 Oct;66(10):5036-40. Unique Identifier : AIDSLINE MED/98427180; Roberts AD; Orme IM; Mycobacteria Research Laboratories, Department of Microbiology,; Colorado State University, Fort Collins, Colorado 80523, USA.; The interaction between CD95 and its ligand is an important homeostatic mechanism that leads to the induction of apoptosis in activated T cells. In view of recent evidence that this pathway might be defective in aged mice, this study investigated CD95 expression on T cells in old mice activated by infection with Mycob
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.: Infect Immun. 1998 Nov;66(11):5073-81. Unique Identifier : AIDSLINE MED/99003112; Wizel B; Garg N; Tarleton RL; Department of Cellular Biology, University of Georgia, Athens,; Georgia 30602, USA.; DNA vaccination was evaluated with the experimental murine model of Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1 (TSA-1), a target of anti-T. cruzi antibody and major histocompatibility complex (MHC) class I-restricted CD8(+) cytotoxic T-ly
Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens.: Infect Immun. 1998 Nov;66(11):5082-8. Unique Identifier : AIDSLINE MED/99003113; Mason KM; Dryden TD; Bigley NJ; Fink PS; Department of Microbiology and Immunology, Wright State; University, Dayton, Ohio 45435, USA.; Superantigens stimulate T-lymphocyte proliferation and cytokine production, but the effects of superantigen exposure on cell function within a complex, highly regulated immune response remain to be determined. In this study, we demonstrate that superantigen exposure significantly alters the murine host response to bac
Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections.: Infect Immun. 1998 Nov;66(11):5167-74. Unique Identifier : AIDSLINE MED/99003124; Helmby H; Kullberg M; Troye-Blomberg M; Department of Immunology, Stockholm University, Stockholm,; Sweden. helena@imm2.su.se; Mixed parasitic infections are common in many parts of the world. However, little is known about how concurrent infections affect the immunity to and/or pathogenesis of each other. Protection and elimination of blood-stage Plasmodium chabaudi chabaudi AS in resistant mice are characterized by a sequential activation o
Transmission and serial propagation of Enterocytozoon bieneusi from humans and Rhesus macaques in gnotobiotic piglets.: Infect Immun. 1998 Nov;66(11):5515-9. Unique Identifier : AIDSLINE MED/99003171; Kondova I; Mansfield K; Buckholt MA; Stein B; Widmer G; Carville A; Lackner A; Tzipori S; Division of Infectious Disease, Tufts University School of; Veterinary Medicine, North Grafton, Massachusetts 01536, USA.; For over a decade Enterocytozoon bieneusi infections in people with AIDS have been linked with chronic diarrhea and wasting. The slow scientific progress in treating these infections is attributed to the inability of investigators to cultivate the parasite, which has also precluded evaluation of effective therapies. W
Murine model of Bartonella henselae infection in the immunocompetent host.: Infect Immun. 1998 Nov;66(11):5534-6. Unique Identifier : AIDSLINE MED/99003174; Regnath T; Mielke ME; Arvand M; Hahn H; Institute of Infectious Diseases, University Hospital Benjamin; Franklin, Free University of Berlin, 12203 Berlin, Germany.; regnath@zedat.fu-berlin.de; Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis , and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraper
Protection by CD4 or CD8 T cells against pulmonary Mycobacterium bovis bacillus Calmette-Guerin infection.: Infect Immun. 1998 Nov;66(11):5537-42. Unique Identifier : AIDSLINE MED/99003175; Xing Z; Wang J; Croitoru K; Wakeham J; Department of Pathology and Division of Infectious Diseases,; Centre for Gene Therapeutics, McMaster University, Hamilton,; Ontario, Canada. xing@fhs.csu.mcmaster.ca; Mice deficient in CD8 T cells demonstrated levels of Th1 cytokines and granulomatous responses in the lungs very similar to those demonstrated by normal control mice and were fully capable of controlling pulmonary mycobacterial infection by Mycobacterium bovis BCG as assessed at day 37 postinfection. In comparison, mi
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.: Infect Immun. 1998 Nov;66(11):5543-6. Unique Identifier : AIDSLINE MED/99003176; Sommer F; Faller G; Konturek P; Kirchner T; Hahn EG; Zeus J; Rollinghoff M; Lohoff M; Institut fur Klinische Mikrobiologie, Immunologie und Hygiene; der Universitat Erlangen-Nurnberg, Erlangen, Germany.; sommer@mikrobio.med.uni.erlangen.de; In this study, cytokine patterns produced by CD4(+) T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cy
An assessment of cross-infection control procedures among English-speaking Caribbean general dental practitioners. A regional preliminary study.: Int Dent J. 1998 Apr;48(2):67-76. Unique Identifier : AIDSLINE MED/98452108; Vignarajah S; Eastmond VH; Ashraph A; Rashad M; Dental Clinic, St. John's, Antigua, W.I.; A survey was undertaken to assess the level of compliance with recommended infection control procedures among English-speaking Caribbean general dental practitioners. A four page questionnaire was sent to all practitioners in 18 English-speaking Caribbean islands. A response rate of 32 per cent was obtained. A large p
Effects of zinc supplementation on the immune system and on antibody response to multivalent influenza vaccine in hemodialysis patients.: Int J Artif Organs. 1998 May;21(5):274-8. Unique Identifier : AIDSLINE MED/98348051; Turk S; Bozfakioglu S; Ecder ST; Kahraman T; Gurel N; Erkoc R; Aysuna N; Turkmen A; Bekiroglu N; Ark E; Department of Internal Medicine, Medical School of Istanbul,; Turkey.; The depression of the immune system in chronic uremia is a well-known phenomenon but the role of serum zinc (Zn) levels on both cell-mediated and humoral immunity is still controversial. The aim of this study was to investigate the effect of Zn supplementation on the immune system and on antibody response to multivale
2,3,7,8-Tetrachlorodibenzo-p-dioxin co-stimulates staphylococcal enterotoxin beta (SEB) cytokine production and phenotypic cell cycling in Long-Evans rats.: Int J Immunopharmacol. 1998 Jan-Mar;20(1-3):39-56. Unique Identifier : AIDSLINE MED/98382809; Huang W; Koller LD; College of Veterinary Medicine, Oregon State University,; Corvallis 97331, USA.; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that is considered to be a potent immunotoxicant. In the present study, we examined the effect of 25 micrograms/kg TCDD on cytokine production and T lymphocyte phenotype, cell cycling and receptor activity in female Long-Evans rats that had bee
AIDS control and the workplace: the role of occupational health services in South Africa.: Int J Health Serv. 1998;28(3):575-91. Unique Identifier : AIDSLINE MED/98377360; London L; Department of Community Health, University of Cape Town Medical; School, Observatory, South Africa.; AIDS interventions typically fail to address the disjuncture between private behaviors and the social determinants of HIV infection. Data from a telephone survey of manufacturing companies and a postal survey of occupational health nurses in the Western Cape, South Africa , were us
Lupus erythematosus-like features in patients with cutaneous T-cell lymphoma.: Int J Dermatol. 1998 Aug;37(8):579-85. Unique Identifier : AIDSLINE MED/98400750; McBurney EI; Hickham PR; Garry RF; Reed RJ; Department of Dermatology, Louisiana State University School of; Medicine, New Orleans, USA.; BACKGROUND: The development of lupus erythematosus-like (LE-like) features in patients with cutaneous T-cell lymphoma (CTCL) has not been reported previously in the literature. Both diseases, however, have been etiologically linked to retroviruses. OBJECTIVE: Our purpose was to report four cases of patients with CTCL
Skin diseases in Bamako (Mali).: Int J Dermatol. 1998 Sep;37(9):673-6. Unique Identifier : AIDSLINE MED/98433781; Mahe A; Cisse IAh; Faye O; N'Diaye HT; Niamba P; Institut Marchoux, Bamako, Republic of Mali.; BACKGROUND: Skin diseases have only recently been considered as a possible public health problem in developing countries. Data supporting this matter are scarce. The aim of this study is to report the experience of a specialized dermatologic center in Bamako ( Mali ) in order to comple
Porphyria cutanea tarda in a human immunodeficiency virus-infected patient: treatment with N-acetyl-cysteine [letter]: Int J Dermatol. 1998 Sep;37(9):718-9. Unique Identifier : AIDSLINE MED/98433797; Binet H; Simonart T; Van Vooren JP; Heenen M; Liesnard C; Delforge ML; Farber CM; Parent D
Role of T lymphocytes and cytokines in coccidiosis.: Int J Parasitol. 1998 Jul;28(7):1071-81. Unique Identifier : AIDSLINE MED/98392090; Lillehoj HS; Immunology and Disease Resistance Laboratory, US Department of; Agriculture, Beltsville, MD 20705, USA. hlilleho@ggpl.arsusda.gov; Development of a vaccine for avian coccidiosis has been hampered by lack of understanding of the various components of the host immune system leading to protective immunity. Clear understanding of the cellular dichotomy in cytokine production in mice and the availability of immunological reagents, as well as gene knoc
Intestinal nematode parasites, cytokines and effector mechanisms.: Int J Parasitol. 1998 Aug;28(8):1145-58. Unique Identifier : AIDSLINE MED/98435307; Else KJ; Finkelman FD; School of Biological Sciences, University of Manchester, U.K.; Kathryn.J.Else@man.ac.uk; Laboratory models of intestinal nematode infection have played an important role in developing our understanding of the immune mechanisms that operate against infectious agents. The type of helper T cell response that develops following infection with intestinal nematode parasites is critical to the outcome of infecti
Identification of a human isolate of Encephalitozoon cuniculi type I from Italy.: Int J Parasitol. 1998 Sep;28(9):1361-6. Unique Identifier : AIDSLINE MED/98443560; Rossi P; La Rosa G; Ludovisi A; Tamburrini A; Gomez Morales MA; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.; A microsporidial strain, obtained from a person with AIDS living in Italy was isolated and cultivated on RK13 (rabbit kidney) cell monolayers. Identification at the species level was performed by immunological and molecular methods. Western blot analysis showed that the human isolat
Intravenous acyclovir treatment for extensive herpetic keratitis in a liver transplant patient.: Int Ophthalmol. 1997-98;21(5):265-8. Unique Identifier : AIDSLINE MED/98427865; Oshry T; Lifshitz T; Department of Ophthalmology, Soroka Medical Center, Ben Gurion; University, Beer Sheva, Israel.; Herpetic infection is a common complication among immune suppressed patients following heart, kidney and bone marrow transplantations, in leukemia patients, in AIDS patients, and during treatment with cytotoxic drugs. In the cases described in the literature, oral acyclovir was
AIDS in ENT in children.: Int J Pediatr Otorhinolaryngol. 1998 Jul 10;44(2):103-7. Unique Identifier : AIDSLINE MED/98391341; Chaloryoo S; Chotpitayasunondh T; Chiengmai PN; Department of Otolaryngology, Children's Hospital, Queen Sirikit; National Institute of Child Health, Bangkok, Thailand.; Human immunodeficiency virus (HIV) infection is one of the most widespread diseases in the world. By the end of 1995, 800,000 HIV infected persons were suspected in Thailand , although the reported number of symptomatic HIV patients was only 13,267 and the number of cases of acqui
Nurses intensify worldwide efforts to ensure HIV/AIDS care for all [news]: Int Nurs Rev. 1998 Jul-Aug;45(4):104. Unique Identifier : AIDSLINE MED/98397543
Mother-to-child transmission of human immunodeficiency virus (HIV) in Ireland: a prospective study.: Ir J Med Sci. 1998 Jul-Sep;167(3):145-8. Unique Identifier : AIDSLINE MED/98453846; Nourse CB; Conlon T; Hayes E; Kaminski G; Griffin E; Hillary I; Butler KM; Department of Paediatrics, University College Dublin.; Symptomatic HIV infection was first diagnosed in an Irish child in 1985. A prospective study was initiated to determine the vertical transmission rate (VTR) of HIV and the average age of infant seroreversion and to monitor clinical, immunologic and virologic evidence for HIV infection in seroreverters. Ninety three HI
Activation of transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat by the vasoactive intestinal peptide (VIP).: Ital J Biochem. 1998 Jun;47(2):101-10. Unique Identifier : AIDSLINE MED/98413482; Gilles A; Miquelis A; Luis J; Faure E; Universite de Provence, Marseille, France.; The ability of the human immunodeficiency virus type 1 (HIV-1) to persist and replicate in human CD4+ cells is under the control of both virally encoded proteins and a variety of host-related factors. Transcription of human immunodeficienty virus type 1 (HIV-1) is regulated by multiple cis-acting regulatory elements l
[Papular exanthema in systemic histoplasmosis and HIV infection]: Hautarzt. 1998 Jul;49(7):581-5. Unique Identifier : AIDSLINE MED/98381177; Schofer H; Baur S; Zentrum der Dermatologie und Venerologie, Johann Wolfgang; Goethe-Universitat Frankfurt/Main.; A 34-year-old HIV-infected African woman developed fever, weight loss and widespread papules on her trunk, arms and face. Skin biopsy and culture revealed histoplasmosis caused by Histoplasma capsulatum varietas capsulatum (American histoplasmosis). Even though antimycotic treatment and intensive care were started imm
Persons with AIDS: living with pain at home.: Home Healthc Nurse. 1998 Aug;16(8):555-9; quiz 559-60. Unique Identifier : AIDSLINE MED/99024435; Hartman JL; Szigeti E; University of North Dakota, Grand Forks, USA.; Pain is a significant symptom for patients with AIDS. This article reviews the prevalence and etiology of pain in patients with AIDS, and examines current recommendations for treatment. Implications for the home healthcare professional are included.
Human T-lymphotropic virus type-I infection, antibody titers and cause-specific mortality among atomic-bomb survivors.: Jpn J Cancer Res. 1998 Aug;89(8):797-805. Unique Identifier : AIDSLINE MED/98438751; Arisawa K; Soda M; Akahoshi M; Matsuo T; Nakashima E; Tomonaga M; Saito H; Department of Epidemiology, Radiation Effects Research; Foundation, Nagasaki.; There have been few longitudinal studies on the long-term health effects of human T-lymphotropic virus type-I (HTLV-I) infection. The authors performed a cohort study of HTLV-I infection and cause-specific mortality in 3,090 atomic-bomb survivors in Nagasaki, Japan , who were followe
In-vitro activity of lytic peptides, inhibitors of ion transport systems and ionophorous antibiotics against Pneumocystis carinii.: J Antimicrob Chemother. 1998 Aug;42(2):141-5. Unique Identifier : AIDSLINE MED/98409210; Cirioni O; Giacometti A; Barchiesi F; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Italy. cmalinif@popcsi.unian.it; The in-vitro activity of two vertebrate lytic peptides, two ion transport system inhibitors and two polyether ionophores was investigated against four clinical isolates of Pneumocystis carinii recovered from bronchoalveolar lavages of AIDS patients. The susceptibility tests were performed by inoculating the isolates o
In-vitro susceptibility of Cryptococcus neoformans isolates to fluconazole and itraconazole.: J Antimicrob Chemother. 1998 Aug;42(2):217-20. Unique Identifier : AIDSLINE MED/98409219; Davey KG; Johnson EM; Holmes AD; Szekely A; Warnock DW; PHLS Mycology Reference Laboratory, Public Health Laboratory,; Kingsdown, Bristol, UK.; The in-vitro susceptibilities of 143 isolates of Cryptococcus neoformans, collected from British patients between 1994 and 1996, to fluconazole and itraconazole were compared with those of 36 isolates collected between 1971 and 1985, 41 isolates collected between 1986 and 1989, and 43 Ugandan isolates collected in 199
Arkansas HIV/AIDS Report.: J Ark Med Soc. 1998 Oct;95(5):209-11. Unique Identifier : AIDSLINE MED/99012270; The cumulative total of HIV cases is 4,110. Of that number, 2,481 meet the AIDS case definition. For the month ending July 12 of this year, there were 87 new HIV and 60 new AIDS cases reported. Of the 2,481 AIDS cases reported since 1983, 1210 (49%) have died of AIDS.
Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter.: J Biochem (Tokyo). 1998 Aug;124(2):389-95. Unique Identifier : AIDSLINE MED/98351998; Suzuki T; Yamamoto T; Kurabayashi M; Nagai R; Yazaki Y; Horikoshi M; Departments of Developmental Biology and Cellular Biology,; Institute of Molecular and Cellular Biosciences, The University; of Tokyo, Bunkyo-ku, Tokyo, 113-0032, Japan.; Human immunodeficiency virus (HIV) and its clinical syndrome, acquired immune deficiency syndrome (AIDS), are one of the world s most prominent health problems. To understand the mechanisms underlying HIV transcription and thereby its propagation, we have focused on the molecular interactions at the GC-rich binding si
The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence.: J Biol Chem. 1998 Oct 2;273(40):26202-9. Unique Identifier : AIDSLINE MED/98421550; Guadiz G; Haidaris CG; Maine GN; Simpson-Haidaris PJ; Departments, University of Rochester School of Medicine and; Dentistry, Rochester, New York 14642, USA.; Pneumocystis carinii pneumonia is a hallmark disease associated with AIDS. An abundant glycoprotein, termed gpA, on the surface of P. carinii is considered an important factor in host-parasite interactions. The primary structure of ferret P. carinii gpA contains a carboxyl-terminal sequence characteristic of a signal
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.: J Biol Chem. 1998 Oct 16;273(42):27250-8. Unique Identifier : AIDSLINE MED/98438493; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, the; Pennsylvania State University, University Park, Pennsylvania; 16802, USA.; (R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA) is an acyclic nucleoside phosphonate that has been shown to be effective in the treatment of AIDS although it has a shorter separation between the adenine and phosphorus than dideoxy-AMP and dAMP. By using pre-steady state kinetic methods, we examined the incorporation o
DNA secondary structure effects on DNA synthesis catalyzed by HIV-1 reverse transcriptase.: J Biol Chem. 1998 Oct 16;273(42):27259-67. Unique Identifier : AIDSLINE MED/98438494; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, the; Pennsylvania State University, University Park, Pennsylvania; 16802, USA.; The effect of DNA secondary structure on polymerization catalyzed by human immunodeficiency virus (HIV-1) reverse transcriptase (RT) was studied using a synthetic 66-nucleotide DNA template containing a stable hairpin structure. Four RT pause sites were identified within the first half of the hairpin stem. Additionall
Prostaglandin E2 Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways.: J Biol Chem. 1998 Oct 16;273(42):27306-14. Unique Identifier : AIDSLINE MED/98438501; Dumais N; Barbeau B; Olivier M; Tremblay MJ; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire de Quebec, Pavillon CHUL, and Departement de; Biologie medicale, Faculte de Medecine, Universite Laval,; Ste-Foy, Quebec G1V 4G2, Canada.; Replication of human immunodeficiency virus type-1 (HIV-1) is highly dependent on the state of activation of the infected cells and is modulated by interactions between viral and host cellular factors. Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, is observed at elevated levels during HIV-1 infecti
An extended alpha-helix and specific amino acid residues opposite the DNA-binding surface of the cAMP response element binding protein basic domain are important for human T cell lymphotropic retrovirus type I Tax binding.: J Biol Chem. 1998 Oct 16;273(42):27339-46. Unique Identifier : AIDSLINE MED/98438506; Tang Y; Tie F; Boros I; Harrod R; Glover M; Giam CZ; Department of Microbiology and Immunology, Uniformed Services; University, Bethesda, Maryland 20814, USA.; The human T cell lymphotropic retrovirus type I (HTLV-I) trans-activator, Tax, interacts specifically with the basic-domain/leucine-zipper (bZip) protein, cAMP response element binding protein (CREB), bound to the viral Tax-responsive element consisting of three imperfect 21-base pair repeats, each with a cAMP respons
Identification of limiting steps for efficient trans-activation of HIV-1 promoter by Tat in Saccharomyces cerevisiae.: J Biol Chem. 1998 Oct 23;273(43):28219-28. Unique Identifier : AIDSLINE MED/98447674; Daviet L; Bois F; Battisti PL; Gatignol A; Unite 332, INSERM, Institut Cochin de Genetique Moleculaire,; 22, rue Mechain, 75014 Paris, France.; Cellular context is an important determinant for the activity of Tat, the trans-activator of human immunodeficiency virus (HIV). We have investigated HIV-1 promoter expression and trans-activation in Saccharomyces cerevisiae to provide clues about the limiting steps for Tat activity in this organism. A minimal 43-nucl
The nature of human immunodeficiency virus type 1 strand transfers.: J Biol Chem. 1998 Oct 23;273(43):28384-91. Unique Identifier : AIDSLINE MED/98447696; Yu H; Jetzt AE; Ron Y; Preston BD; Dougherty JP; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, Piscataway, New Jersey 08854, USA.; The diploid nature of human immunodeficiency virus type 1 (HIV-1) suggests that recombination serves a central function in virus replication and evolution. A system was developed to examine HIV-1 strand transfers, including the obligatory DNA primer strand transfers as well as recombinational crossovers during reverse
Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation.: J Biol Chem. 1998 Oct 23;273(43):28392-8. Unique Identifier : AIDSLINE MED/98447697; Asada A; Zhao Y; Kondo S; Iwata M; Integrative Projects, Mitsubishi Kasei Institute of Life; Sciences, 11 Minamiooya, Machida-shi, Tokyo 194, Japan.; Glucocorticoids appear to participate in apoptosis of unselected CD4(+)CD8(+) thymocytes. Activation of Ca2+-independent novel protein kinase C (nPKC) precedes glucocorticoid-induced thymocyte apoptosis, while proper levels of Ca2+-dependent protein kinase C (cPKC) and calcineurin activities contribute to rescue thymo
Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization.: J Cell Biochem. 1998 Oct 1;71(1):36-45. Unique Identifier : AIDSLINE MED/98405859; Zhao J; Ma L; Wu YL; Wang P; Hu W; Pei G; Shanghai Institute of Cell Biology, Chinese Academy of Sciences,; People's Republic of China.; Chemokine receptor CCR5 is not only essential for chemotaxis of leukocytes but also has been shown to be a key coreceptor for HIV-1 infection. In the present study, hemagglutinin epitope-tagged human CCR5 receptor was stably expressed in Chinese hamster ovary cells or transiently expressed in NG108-15 cells to investi
Leg pain and swelling in an HIV-infected drug abuser.: Hosp Pract (Off Ed). 1998 Oct 15;33(10):195-7. Unique Identifier : AIDSLINE MED/99009945; Formica R; Perazella MA; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Conn., USA.
Severe deficiency of 1,25-dihydroxyvitamin D3 in human immunodeficiency virus infection: association with immunological hyperactivity and only minor changes in calcium homeostasis.: J Clin Endocrinol Metab. 1998 Nov;83(11):3832-8. Unique Identifier : AIDSLINE MED/99029591; Haug CJ; Aukrust P; Haug E; Morkrid L; Muller F; Froland SS; Medical Department A, and Research Institute for Internal; Medicine, University of Oslo, Norway.; The serum level of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D], the biologically most potent metabolite of vitamin D, is tightly regulated within narrow limits in human healthy adults. 1,25-(OH)2D deficiency is rare and is associated with disturbances in calcium and bone metabolism. We have previously reported a marked dec
Chemokine receptors and chemokines in HIV infection.: J Clin Immunol. 1998 Jul;18(4):243-55. Unique Identifier : AIDSLINE MED/98376600; Garzino-Demo A; DeVico AL; Gallo RC; Institute of Human Virology, University of Maryland, Baltimore; 21201-1192, USA.; Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as coreceptors for entry into host cells. Human genotypes
A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule?: J Clin Immunol. 1998 Jul;18(4):256-63. Unique Identifier : AIDSLINE MED/98376601; Gupta S; Aggarwal S; Nakamura S; Department of Medicine, University of California, Irvine 92697,; USA. sgupta@uci.edu; Kaposi s sarcoma (KS) is considered a disorder of cytokines. Basic fibroblast growth factor (bFGF) is produced by AIDS-associated KS (AIDS-KS) cells and supports their growth in an autocrine and paracrine manner. bFGF lacks a signal sequence; therefore, its mechanism of secretion is unclear. In this study, we investig
Slowed information processing in HIV-1 disease. The Multicenter AIDS Cohort Study (MACS).: J Clin Exp Neuropsychol. 1998 Feb;20(1):60-72. Unique Identifier : AIDSLINE MED/98336691; Llorente AM; Miller EN; D'Elia LF; Selnes OA; Wesch J; Becker JT; Satz P; Department of Psychiatry and Biobehavioral Sciences, University; of California School of Medicine, Los Angeles, CA, USA.; This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV-positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning,
Prevalence of Candida dubliniensis isolates in a yeast stock collection.: J Clin Microbiol. 1998 Oct;36(10):2869-73. Unique Identifier : AIDSLINE MED/98411395; Odds FC; Van Nuffel L; Dams G; Department of Bacteriology and Mycology, Janssen Research; Foundation, 2340 Beerse, Belgium. fodds@janbe.jnj.com; To establish the historical prevalence of the novel yeast species Candida dubliniensis, a survey of 2,589 yeasts originally identified as Candida albicans and maintained in a stock collection dating back to the early 1970s was undertaken. A total of 590 yeasts, including 93 (18.5%) beta-glucosidase-negative isolates a
Fluconazole susceptibility testing of Cryptococcus neoformans: comparison of two broth microdilution methods and clinical correlates among isolates from Ugandan AIDS patients.: J Clin Microbiol. 1998 Oct;36(10):2874-6. Unique Identifier : AIDSLINE MED/98411396; Jessup CJ; Pfaller MA; Messer SA; Zhang J; Tumberland M; Mbidde EK; Ghannoum MA; Mycology Reference Laboratory, Center for Medical Mycology,; Department of Dermatology, Case Western Reserve University and; University Hospitals of Cleveland, Ohio, USA.; We compared the yeast nitrogen base (YNB) broth microdilution method with the National Committee for Clinical Laboratory Standards (NCCLS) M27-A microdilution reference method for measuring the in vitro susceptibility of Cryptococcus neoformans isolates to fluconazole. A total of 149 isolates of C. neoformans var. neo
Prolonged replication of a type 1 vaccine-derived poliovirus in an immunodeficient patient.: J Clin Microbiol. 1998 Oct;36(10):2893-9. Unique Identifier : AIDSLINE MED/98411400; Kew OM; Sutter RW; Nottay BK; McDonough MJ; Prevots DR; Quick L; Pallansch MA; Division of Viral and Rickettsial Diseases, National Center for; Infectious Diseases, National Immunization Program, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; omk1@cdc.gov; VP1 sequences were determined for poliovirus type 1 isolates obtained over a 189-day period from a poliomyelitis patient with common variable immunodeficiency syndrome (a defect in antibody formation). The isolate from the first sample, taken 11 days after onset of paralysis, contained two poliovirus populations, diff
Ultrasensitive reverse transcription-PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1998 Oct;36(10):2964-9. Unique Identifier : AIDSLINE MED/98411411; Sun R; Ku J; Jayakar H; Kuo JC; Brambilla D; Herman S; Rosenstraus M; Spadoro J; Roche Molecular Systems, Inc., Branchburg, New Jersey 08876, USA.; With the recent introduction of combination therapy , human immunodeficiency virus type 1 (HIV-1) RNA levels in plasma have been dramatically reduced, frequently to below the limit of quantitation (400 copies/ml of plasma) of the AMPLICOR HIV-1 MONITOR Test (Roche Diagn
Comparison of different DNA fingerprinting techniques for molecular typing of Bartonella henselae isolates.: J Clin Microbiol. 1998 Oct;36(10):2973-81. Unique Identifier : AIDSLINE GENBANK/AJ223780; Sander A; Ruess M; Bereswill S; Schuppler M; Steinbrueckner B; Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische; Mikrobiologie und Hygiene, Klinikum der Universitat Freiburg,; Freiburg, Germany. Sander@ukl.uni-freiburg.de; Seventeen isolates of Bartonella henselae from the region of Freiburg, Germany , obtained from blood cultures of domestic cats, were examined for their genetic heterogeneity. On the basis of different DNA fingerprinting methods, including pulsed-field gel electrophoresis (PFGE), en
Hepatitis C virus serotype-specific core and NS4 antibodies in injecting drug users participating in the Amsterdam cohort studies.: J Clin Microbiol. 1998 Oct;36(10):3002-6. Unique Identifier : AIDSLINE MED/98411417; Beld M; Penning M; van Putten M; van den Hoek A; Lukashov V; McMorrow M; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, Amsterdam, The Netherlands.; M.Beld@AMC.UvA.NL; In the present study, the RIBA HCV serotyping SIA was evaluated with a cohort of injecting drug users. Serotyping may be a rapid and cost-effective method of determining genotypes in cohort studies. In this study, hepatitis C virus (HCV) antibody-positive sera from a cohort of 331 chronically infected injecting drug u
Detection of Candida dubliniensis in oropharyngeal samples from human immunodeficiency virus-infected patients in North America by primary CHROMagar candida screening and susceptibility testing of isolates.: J Clin Microbiol. 1998 Oct;36(10):3007-12. Unique Identifier : AIDSLINE MED/98411418; Kirkpatrick WR; Revankar SG; Mcatee RK; Lopez-Ribot JL; Fothergill AW; McCarthy DI; Sanche SE; Cantu RA; Rinaldi MG; Patterson TF; Departments of Medicine, The University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78284, USA.; Candida dubliniensis has been associated with oropharyngeal candidiasis in patients infected with human immunodeficiency virus (HIV). C. dubliniensis isolates may have been improperly characterized as atypical Candida albicans due to the phenotypic similarity between the two species. Prospective screening of oral rins
Detection of specific antibodies to an antigenic mannoprotein for diagnosis of Penicillium marneffei penicilliosis.: J Clin Microbiol. 1998 Oct;36(10):3028-31. Unique Identifier : AIDSLINE MED/98411421; Cao L; Chen DL; Lee C; Chan CM; Chan KM; Vanittanakom N; Tsang DN; Yuen KY; Department of Microbiology, The University of Hong Kong.; lcao@hkucc.Hku.hk; The disseminated and progressive fungal disease Penicillium marneffei penicilliosis is one of the most common infectious diseases in AIDS patients in Southeast Asia. To diagnose systemic penicilliosis, we developed an enzyme-linked immunosorbent assay (ELISA)-based antibody test with Mp1p, a purified recombinant antig
IS1245 restriction fragment length polymorphism typing of Mycobacterium avium isolates: proposal for standardization.: J Clin Microbiol. 1998 Oct;36(10):3051-4. Unique Identifier : AIDSLINE MED/98411427; van Soolingen D; Bauer J; Ritacco V; Leao SC; Pavlik I; Vincent V; Rastogi N; Gori A; Bodmer T; Garzelli C; Garcia MJ; Diagnostic Laboratory of Infectious Diseases and Perinatal; Screening, National Institute of Public Health and the; Environment, 3720 BA Bilthoven, The Netherlands.; D.van.Soolingen@rivm.nl; Mycobacterium avium has become a major human pathogen, primarily due to the emergence of the AIDS epidemic. Restriction fragment length polymorphism (RFLP) typing, using insertion sequence IS1245 as a probe, provides a powerful tool in the molecular epidemiology of M. avium-related infections and will facilitate well-
Genetic analysis of Histoplasma capsulatum strains isolated from clinical specimens in thailand by a PCR-based random amplified polymorphic DNA method.: J Clin Microbiol. 1998 Oct;36(10):3073-6. Unique Identifier : AIDSLINE GENBANK/AB011366; Poonwan N; Imai T; Mekha N; Yazawa K; Mikami Y; Ando A; Nagata Y; Department of Medical Sciences, National Institute of Health,; Nonthaburi, Thailand.; Thirteen strains of Histoplasma capsulatum were isolated from clinical specimens, including those from AIDS patients, in Thailand . Random amplified polymorphic DNA (RAPD) analysis with three different PCR primers showed that the DNA fingerprint patterns of the Thai isolates were
PCR-based rapid detection of Mycobacterium tuberculosis in blood from immunocompetent patients with pulmonary tuberculosis.: J Clin Microbiol. 1998 Oct;36(10):3094-5. Unique Identifier : AIDSLINE MED/98411440; Ahmed N; Mohanty AK; Mukhopadhyay U; Batish VK; Grover S; Molecular Biology Unit, National Dairy Research Institute, Karnal; 132001, India. niyaz@mailcity.com; A PCR test based on insertion sequence IS1081 was developed to detect Mycobacterium tuberculosis complex organisms in the peripheral blood. The method was applied to blood samples from immunocompetent individuals with localized pulmonary tuberculosis. Seven of 16 (43.75%) blood samples were found to be positive for th
Heat shock proteins and experimental autoimmune encephalomyelitis. II: environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis.: J Neuroimmunol. 1998 Oct 1;90(2):149-61. Unique Identifier : AIDSLINE MED/99032381; Birnbaum G; Kotilinek L; Miller SD; Raine CS; Gao YL; Lehmann PV; Gupta RS; Department of Neurology, University of Minnesota, Minneapolis,; USA. birnb001@tc.umn.edu; We wished to study how infections might trigger relapses of autoimmune diseases such as multiple sclerosis (MS) and encephalomyelitis (EAE). We hypothesized that immune responses to heat shock proteins (hsp) induced by an infection could modulate responses to autoantigens. We induced extra-neuraxial inflammation in SJ
Predominant expression of Fas ligand mRNA in CD8+ T lymphocytes in patients with HTLV-1 associated myelopathy.: J Neuroimmunol. 1998 Oct 1;90(2):199-206. Unique Identifier : AIDSLINE MED/99032386; Kawahigashi N; Furukawa Y; Saito M; Usuku K; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.; To determine if Fas ligand (FasL) mediated apoptosis is involved in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we examined the expression of FasL mRNA in fresh uncultured peripheral blood mononuclear cells (PBMC) from 17 Japanese patients with HAM/TSP, four adult T-cell le
Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation.: J Clin Invest. 1998 Oct 1;102(7):1332-44. Unique Identifier : AIDSLINE MED/98443223; Koziel H; Eichbaum Q; Kruskal BA; Pinkston P; Rogers RA; Armstrong MY; Richards FF; Rose RM; Ezekowitz RA; Division of Pulmonary and Critical Care Medicine, Department of; Medicine, Beth Israel Deaconess Medical Center and Harvard; Medical School, Boston, Massachusetts 02215, USA.; hkoziel@bidmc.harvard.edu; The macrophage mannose receptor, a pattern recognition molecule and component of innate immunity, mediates binding and phagocytosis of Pneumocystis carinii and likely represents an important clearance mechanism in the lungs of immunocompetent hosts. The purpose of this study was to examine the ability of alveolar macr
The chemokine kidnapping receptor of HHV8 [editorial; comment]: J Clin Invest. 1998 Oct 15;102(8):1467-8. Unique Identifier : AIDSLINE MED/99007381; Howard OM; Farrar WL
Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture [see comments]: J Clin Invest. 1998 Oct 15;102(8):1469-72. Unique Identifier : AIDSLINE MED/99007382; Gershengorn MC; Geras-Raaka E; Varma A; Clark-Lewis I; Division of Molecular Medicine, Department of Medicine, Cornell; University Medical College and The New York Hospital, New York; 10021, USA. mcgersh@mail.med.cornell.edu; Kaposi s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi s sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling. In this report, we show that two chemokines, interleukin
Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.: J Clin Invest. 1998 Oct 15;102(8):1473-80. Unique Identifier : AIDSLINE MED/99007383; Bajaj-Elliott M; Poulsom R; Pender SL; Wathen NC; MacDonald TT; Department of Paediatric Gastroenterology, St. Bartholomew's and; the Royal London School of Medicine and Dentistry, London, United; Kingdom.; Immune reactions in the gut are associated with increased epithelial cell proliferation. Here we have studied the role of keratinocyte growth factor (KGF; FGF7) and transforming growth factor-alpha (TGF-alpha) in the epithelial cell hyperplasia seen in explants of fetal human small intestine after activation of lamina
Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1.: J Clin Invest. 1998 Oct 15;102(8):1540-50. Unique Identifier : AIDSLINE MED/99007391; Moriuchi M; Moriuchi H; Turner W; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. hmoriuchi@atlas.niaid.nih.gov; Microbial coinfections variably influence HIV-1 infection through immune activation or direct interaction of microorganisms with HIV-1 or its target cells. In this study, we investigated whether exposure of macrophages to bacterial products impacts the susceptibility of these cells to HIV-1 of different cellular tropi
Safety, pharmacokinetics, and antiretroviral activity of the potent, specific human immunodeficiency virus protease inhibitor nelfinavir: results of a phase I/II trial and extended follow-up in patients infected with human immunodeficiency virus.: J Clin Pharmacol. 1998 Aug;38(8):736-43. Unique Identifier : AIDSLINE MED/98391366; Moyle GJ; Youle M; Higgs C; Monaghan J; Prince W; Chapman S; Clendeninn N; Nelson MR; Chelsea and Westminster Hospital, London, England.; The safety, antiretroviral activity, and pharmacokinetic profile of nelfinavir, a potent and specific inhibitor of human immunodeficiency virus (HIV) protease, were assessed in a small open-label phase I/II dose-ranging study in protease inhibitor-naive HIV-positive men. A total of 22 patients with baseline plasma HIV
Exposure to a community-level HIV prevention intervention: who gets the message.: J Community Health. 1998 Aug;23(4):281-99. Unique Identifier : AIDSLINE MED/98358889; Walls CT; Lauby J; Lavelle K; Derby T; Bond L; Philadelphia Health Management Corporation, PA 19102, USA.; As part of the evaluation of a community-level HIV prevention program for women, this study examined predictors of exposure to print media and community outreach and assessed the relationship between exposure to the intervention and condom use behavior. Data from interviews with 479 women randomly selected from the in
Lymphadenopathy and non-suppurative meningo-encephalitis in calves experimentally infected with bovine immunodeficiency-like virus (FL112).: J Comp Pathol. 1998 Aug;119(2):121-34. Unique Identifier : AIDSLINE MED/98421199; Munro R; Lysons R; Venables C; Horigan M; Jeffrey M; Dawson M; Lasswade Veterinary Laboratory, Bush Estate, Penicuik,; Midlothian, UK.; In an experiment on bovine immunodeficiency-like virus (BIV), the virological and serological aspects of which were reported in an earlier paper, three groups (A, B and C) of three calves were inoculated subcutaneously with a recently isolated strain (FL112). For group B and group C, the virus was suspended in milk, a
Topical and intralesional cidofovir: a review of pharmacology and therapeutic effects.: J Am Acad Dermatol. 1998 Nov;39(5 Pt 1):741-5. Unique Identifier : AIDSLINE MED/99027015; Zabawski EJ Jr; Cockerell CJ; University of Texas Southwestern Medical Center, Dallas, USA.; BACKGROUND: Cidofovir is a potent nucleoside analog antiviral drug approved for the treatment of cytomegalovirus ( CMV ) retinitis in patients with AIDS. It is currently available only for intravenous infusion. Several small st
Carbamazepine and psoriasis [letter]: J Am Acad Dermatol. 1998 Nov;39(5 Pt 1):808-9. Unique Identifier : AIDSLINE MED/99027029; Redondo P; Vazquez-Doval J
Increasing assertiveness skills to reduce HIV risk among women living with a severe and persistent mental illness.: J Consult Clin Psychol. 1998 Aug;66(4):680-4. Unique Identifier : AIDSLINE MED/98406547; Weinhardt LS; Carey MP; Carey KB; Verdecias RN; Department of Psychology, Syracuse University, New York; 13244-2340, USA.; This study examined whether training women living with a severe mental illness to be assertive in sexual situations would decrease their risk for HIV infection. Twenty female outpatients were randomly assigned to either a 10-session assertiveness training intervention or a waiting-list control condition. All participa
Changes in immunological parameters after combination adjuvant therapy with intravenous DTIC, ACNU, and VCR, and local injection of IFN-beta (DAV + IFN-beta therapy) into malignant melanoma.: J Dermatol. 1998 Sep;25(9):569-72. Unique Identifier : AIDSLINE MED/99015076; Umeda T; Aoki K; Yokoyama A; Ohara H; Hayashi O; Tanaka K; Nishioka K; Department of Dermatology, School of Medicine, Tokyo Medical and; Dental University, Japan.; Combination adjuvant therapy with intravenous dimethyl triazeno imidazole carboxamide (DTIC), 1-[4-amino-2-methyl-5-pyrimidinyl]-methyl-3-[2-chloroethyl]-3-nit- rosoure a hydrochloride (ACNU) and vincristine (VCR) and local injection of interferon-beta (IFN-beta) (DAV + IFN-beta therapy) has been widely applied to tre
The fatigue experience: persons with HIV infection.: J Adv Nurs. 1998 Aug;28(2):295-304. Unique Identifier : AIDSLINE MED/98391565; Rose L; Pugh LC; Lears K; Gordon DL; The Johns Hopkins University School of Nursing, Baltimore,; Maryland 21205, USA.; Fatigue is a frequently reported symptom by persons with HIV infection and one that has an adverse impact on activities of daily living and overall quality of life. Although the concept of fatigue has been studied extensively and discussed in the literature, little is known about the experience of fatigue by persons w
Differential regulation of allergen-specific T(H2)- but not T(H1)-type responses by alveolar macrophages in atopic asthma.: J Allergy Clin Immunol. 1998 Sep;102(3):368-75. Unique Identifier : AIDSLINE MED/98439511; Tang C; Rolland JM; Ward C; Thien F; Li X; Gollant S; Walters EH; Department of Medicine, Monash University Medical School,; Melbourne, Australia.; BACKGROUND AND OBJECTIVE: Previous studies have suggested that quantitative differences in TH2-type cytokine responses in the airways are of particular importance in the pathogenesis of asthma. In this study we investigated whether alveolar macrophages (AMs) and peripheral blood monocytes (PMNs) are able to significan
Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E.: J Allergy Clin Immunol. 1998 Sep;102(3):503-11. Unique Identifier : AIDSLINE MED/98439530; Miller RL; Eppinger TM; McConnell D; Cunningham-Rundles C; Rothman P; Department of Medicine, College of Physicians and Surgeons,; Columbia University, New York, NY 10032, USA.; BACKGROUND: Recent data suggest that the regulation of class switching to IgE by cytokines is mediated by STAT transcription factors. The induction of IgE by IL-4 and IL-13 occurs through the activation of the intracellular signal-transducing protein Stat6, whereas the inhibition of IgE class switching by interferon-y
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]: J Fr Ophtalmol. 1998 Mar;21(3):209-13. Unique Identifier : AIDSLINE MED/98431570; Bourcier T; Moldovan M; Goldschild M; Becquet F; Brignole F; Goguel A; Baudouin C; Service d'Ophtalmologie, Hopital Ambroise Pare, Boulogne/Seine.; PURPOSE: Chronic conjunctival inflammatory diseases may depend upon various strongly intricated mechanisms. Discriminating allergy from nonspecific inflammation has become of striking importance for diagnosis and treatment. We investigated conjunctival inflammatory response by comparing two objective biological tools,
[Panophthalmitis and results of HIV tests. Experience at the Cocody University Hospital Center in Abidjan, Ivory Coast]: J Fr Ophtalmol. 1998 Apr;21(4):283-6. Unique Identifier : AIDSLINE MED/98431582; Ahnoux-Zabsonre A; Keita C; Safede K; CHU de Cocody, Cote d'Ivoire.; PURPOSE: We assessed the frequency of panophthalmitis in HIV-infected patients. MATERIALS AND METHODS: Thirty-seven cases of panophthalmitis were screened out of 420 hospitalized patients of ophthalmology department of Cocody Teaching University Hospital, Abidjan, Ivory Coast ,
[Optic neuromyelitis and bilateral acute retinal necrosis due to varicella zoster in a patient with AIDS]: J Fr Ophtalmol. 1998 May;21(5):381-6. Unique Identifier : AIDSLINE MED/98431596; Merle H; Smadja D; Cordoba A; Service d'Ophtalmologie, CHU de Fort de France, Hopital Pierre; Zobda-Quitman, Fort-de-France, Martinique.; We report a case of bilateral acute retinal necrosis (ARN) following an acute optic neuromyelitis (AONM) in an immunodepressed patient (T CD4 lymphocyte count under 50/mm3) suffering from acquired immunodeficiency syndrome (AIDS). Despite the medical treatment the evolution led to blindness by bilateral total retinal
Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity.: Immunopharmacol Immunotoxicol. 1998 Aug;20(3):355-72. Unique Identifier : AIDSLINE MED/98405848; Baxevanis CN; Voutsas IF; Soler MH; Gritzapis AD; Tsitsilonis OE; Stoeva S; Voelter W; Arsenis P; Papamichail M; Cancer Immunology and Immunotherapy Center, St. Savas Cancer; Hospital, Athens, Greece.; This report demonstrates that in vitro activation of human cells with the beta-galactoside-specific lectin from mistletoe (ML-I) or interleukin-2 ( IL-2 ) results in different patterns of activation and function of cytotoxic cells. It is now well established that natural
[Fetal thymic hypoplasia diagnosed after interruption of pregnancy for HIV infection treated with tritherapy]: J Gynecol Obstet Biol Reprod (Paris). 1998 Sep;27(5):533-5. Unique Identifier : AIDSLINE MED/99007794; Cravello L; Fredouille C; Jean-Pastor MJ; Falco JP; Gastaut JA; Service de Gynecologie-Obstetrique B, Hopital de la; Conception, Marseille.; We report an autopsy case of a malformed fetus with thymic hypoplasia. The autopsy was performed after therapeutic termination in the second trimester of pregnancy. The HIV-1 infected mother had received 3 antiviral agents and treatment for opportunistic infections.
Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal.: J Hepatol. 1998 Aug;29(2):306-9. Unique Identifier : AIDSLINE MED/98387668; Altfeld M; Rockstroh JK; Addo M; Kupfer B; Pult I; Will H; Spengler U; Department of Internal Medicine, University of Bonn, Germany.; BACKGROUND/AIMS: In HIV-infected patients, who have recovered completely from an acute hepatitis B infection and become anti-HBs positive, hepatitis B infection may be reactivated after progression to AIDS. CASE REPORT: We present the case of a homosexual male patient with AIDS who developed clinical and serological r
IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.: J Immunol. 1998 Oct 15;161(8):3813-6. Unique Identifier : AIDSLINE MED/98451424; Cohn L; Tepper JS; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520-8011, USA. lauren.cohn@yale.edu; We investigated the role of Th1 or Th2 cells in airway hyperresponsiveness (AHR), because both IFN-gamma and IL-4 and IL-5-producing CD4 T cells have been identified in the airways of asthmatics. After transfer of in vitro-generated TCR transgenic Th1 or Th2 cells and exposure to inhaled Ag, Th2 cells induced AHR and
Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.: J Immunol. 1998 Oct 15;161(8):3817-21. Unique Identifier : AIDSLINE MED/98451425; Zhang DH; Yang L; Ray A; Department of Internal Medicine, Yale University School of; Medicine, New Haven, CT 06520, USA.; The cytokines IL-4 and IL-5 are often coordinately produced by Th2 cells as in asthma. However, it is unclear whether similar molecular mechanisms underlie transcription of the two genes. We have previously shown that the transcription factor GATA-3 is expressed in Th2 but not Th1 cells and is crucial for activation o
GATA-3-dependent enhancer activity in IL-4 gene regulation.: J Immunol. 1998 Oct 15;161(8):3822-6. Unique Identifier : AIDSLINE MED/98451426; Ranganath S; Ouyang W; Bhattarcharya D; Sha WC; Grupe A; Peltz G; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, MO 63110, USA.; Previously, we analyzed the proximal IL-4 promoter in directing Th2-specific activity. An 800-base pair proximal promoter conferred some Th2-selective expression in transgenic mice. However, this region directed extremely low reporter mRNA levels relative to endogenous IL-4 mRNA, suggesting that full gene activity req
High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines.: J Immunol. 1998 Oct 15;161(8):3844-52. Unique Identifier : AIDSLINE MED/98451429; Rogers PR; Huston G; Swain SL; Department of Biology and University of California, San Diego; Cancer Center, La Jolla 92093, USA.; We reevaluated the effects of Ag dose on the polarization of CD4 effectors generated in vitro from naive pigeon cytochrome c-specific TCR transgenic T cells under conditions in which we could eliminate contaminating non-naive CD4 cells and the effects of heterogeneous Ag-presenting populations. When the possibility of
Development of peptide-selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway.: J Immunol. 1998 Oct 15;161(8):3896-901. Unique Identifier : AIDSLINE MED/98451435; Hogquist KA; Bonnevier JL; Department of Laboratory Medicine and Pathology and the Center; for Immunology, University of Minnesota Medical School,; Minneapolis 55455, USA. hogqu001@tc.umn.edu; Fetal thymic organ culture of TCR transgenic (Tg) tissue has been used to study issues of timing and specificity in T cell development. Because most TCR Tgs express a rearranged alphabeta TCR on the cell surface at an earlier stage in development than normal mice, there is a possibility that the conclusions of studies
Lipid vesicle size determines the Th1 or Th2 response to entrapped antigen.: J Immunol. 1998 Oct 15;161(8):4000-7. Unique Identifier : AIDSLINE MED/98451449; Brewer JM; Tetley L; Richmond J; Liew FY; Alexander J; Department of Immunology, University of Strathclyde, Glasgow,; Scotland. j.m.brewer@clinmed.gla.ac.uk; Understanding the factors that control the differential induction of Th1 and Th2 responses is a key immunologic objective with profound implications for vaccination and immunotherapy of infectious and autoimmune diseases. Using Ag formulated in lipid vesicles prepared from nonionic surfactants, we describe a novel mec
Down-regulation of tumoricidal NK and NK T cell activities by MHC Kb molecules expressed on Th2-type gammadelta T and alphabeta T cells coinfiltrating in early B16 melanoma lesions.: J Immunol. 1998 Oct 15;161(8):4138-45. Unique Identifier : AIDSLINE MED/98451466; Seo N; Tokura Y; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan. seo445@hama-med.ac.jp; We examined whether gammadelta T and alphabeta T cells accumulating in early B16 melanoma lesions regulate NK and NK T cells that attack tumor cells. Freshly isolated and cultured tumor-infiltrating lymphocyte (TIL) populations of NK and NK T cells lysed B16 and produced IFN-gamma, whereas gammadelta T and a large par
Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses.: J Immunol. 1998 Oct 15;161(8):4146-52. Unique Identifier : AIDSLINE MED/98451467; Yeung VP; Gieni RS; Umetsu DT; DeKruyff RH; Department of Pediatrics, Stanford University, CA 94305-5208,; USA.; We investigated the capacity of heat-killed Listeria monocytogenes (HKL), a potent stimulator of the innate immune system, as a vaccine adjuvant to modify both primary and secondary Ag-specific immune responses. Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated a KLH-specific primary
Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV.: J Immunol. 1998 Oct 15;161(8):4169-76. Unique Identifier : AIDSLINE MED/98451470; Ruiz ME; Cicala C; Arthos J; Kinter A; Catanzaro AT; Adelsberger J; Holmes KL; Cohen OJ; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1576, USA. mruiz@nih.gov; The present study demonstrates cell surface expression of both CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5), major coreceptors for T cell-tropic and macrophage-tropic strains of HIV, respectively, on CD34+ progenitor cells derived from the peripheral blood. CD34+ progenitor cells were susceptibl
Chronically HIV-1-infected monocytic cells induce apoptosis in cocultured T cells.: J Immunol. 1998 Oct 15;161(8):4257-67. Unique Identifier : AIDSLINE MED/98451481; Chen H; Yip YK; George I; Tyorkin M; Salik E; Sperber K; Division of Clinical Immunology, Mount Sinai Medical Center, New; York, NY 10029, USA.; We have previously developed a human macrophage hybridoma model system to study the effect of HIV-1 infection on monocytic function. Upon coculture of one chronically (35 days postinfection) HIV-1-infected human macrophage hybridoma cell line, 43HIV, there was a dose-dependent decrease in the viability of cocultured A
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.: J Immunol. 1998 Oct 15;161(8):4309-17. Unique Identifier : AIDSLINE MED/98451487; Wang JM; Ueda H; Howard OM; Grimm MC; Chertov O; Gong X; Gong W; Resau JH; Broder CC; Evans G; Arthur LO; Ruscetti FW; Oppenheim JJ; Laboratory of Molecular Immunoregulation, Division of Basic; Sciences, National Cancer Institute, Frederick Cancer Research; and Development Center, MD 21702-1201, USA.; wangji@fcrfv1.ncifcrf.gov; Since HIV-1 infection results in severe immunosuppression, and the envelope protein gp120 has been reported to interact with some of the chemokine receptors on human T lymphocytes, we postulated that gp120 may also affect monocyte activation by a variety of chemokines. This study shows that human peripheral blood mono
Differential binding of IgG and of a HIV gp41 peptide by the B chain and A chain globular head sequences of C1q, respectively.: J Immunol. 1998 Oct 15;161(8):4325-31. Unique Identifier : AIDSLINE MED/98451489; Kojouharova MS; Panchev ID; Tchorbadjieva MI; Reid KB; Hoppe HJ; Department of Biochemistry, Sofia University St. Climent; Ohridsky, Bulgaria.; Two individual globular head regions (ghA and ghB) of the heterotrimeric C1q molecule (containing A, B, and C chains) were expressed in a bacterial expression system using a coproduction with the bacterial chaperone GroESL. The purified proteins were soluble and monomeric, as shown by gel-filtration analysis. No assoc
Detection of HIV-1-specific CTLs in the semen of HIV-infected individuals.: J Immunol. 1998 Oct 15;161(8):4406-10. Unique Identifier : AIDSLINE MED/98451499; Quayle AJ; Coston WM; Trocha AK; Kalams SA; Mayer KH; Anderson DJ; Department of Obstetrics, Gynecology and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 02115, USA. aquayle@rics.bwh.harvard.edu; CTLs play an important role in controlling cell-associated HIV. Since the majority of HIV infections are acquired through sexual transmission, we investigated whether antiviral CTLs were present in the male urogenital tract using semen as a source of T cells. We were able to establish anti-HIV cytolytic lines in five
IL-10 impacts autoimmune diabetes via a CD8+ T cell pathway circumventing the requirement for CD4+ T and B lymphocytes.: J Immunol. 1998 Oct 15;161(8):4420-7. Unique Identifier : AIDSLINE MED/98451501; Balasa B; Davies JD; Lee J; Good A; Yeung BT; Sarvetnick N; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.; IL-10 is essential for an early phase of diabetes in nonobese diabetic (NOD) mice, but later becomes protective against its development. The mechanism by which IL-10 mediates the pathway to diabetes in these mice is unknown. Herein, we dissected the cellular and costimulation requirements for diabetes in transgenic (t
CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice.: J Immunol. 1998 Nov 1;161(9):4463-6. Unique Identifier : AIDSLINE MED/99008497; McCluskie MJ; Davis HL; Loeb Research Institute, Department of Cellular and Molecular; Medicine, Faculty of Medicine, University of Ottawa, Canada.; Mucosal immunity is difficult to induce with subunit vaccines unless such vaccines are administered with a mucosal adjuvant such as cholera toxin (CT); however, CT is toxic in humans. Synthetic oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG) are potent adjuvants for the induction of Th1-like system
Longitudinal analysis of the acute Sendai virus-specific CD4+ T cell response and memory.: J Immunol. 1998 Nov 1;161(9):4530-5. Unique Identifier : AIDSLINE MED/99008509; Topham DJ; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; The development and persistence of Sendai virus-specific CD4+ T cell memory has been analyzed following respiratory infection of C57BL/6J mice by determining the prevalence of IL-2-producing Th cell precursors (Thp). Frequencies as high as 1:40 virus-specific CD4+ T cells were found in the regional lymph nodes and spl
CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge.: J Immunol. 1998 Nov 1;161(9):4563-71. Unique Identifier : AIDSLINE MED/99008514; Gurunathan S; Irvine KR; Wu CY; Cohen JI; Thomas E; Prussin C; Restifo NP; Seder RA; Clinical Immunology Section, Laboratory of Clinical; Investigation, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; CD40/CD40 ligand interactions have a central role in the induction of both humoral and cellular immunity. In this study, we examined whether a plasmid expressing CD40 ligand/trimer (CD40LT) could enhance immune responses in vivo. BALB/c mice were injected with plasmid expressing beta-galactosidase DNA with or without
CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus.: J Immunol. 1998 Nov 1;161(9):4583-90. Unique Identifier : AIDSLINE MED/99008516; Thomsen AR; Nansen A; Christensen JP; Andreasen SO; Marker O; Institute of Medical Microbiology and Immunology, University of; Copenhagen, Denmark. A.R.Thomsen@sb.immi.ku.dk; CD40 ligand (CD40L) is an important molecule that is known to be involved in T-B collaboration and certain aspects of cell-mediated immunity. However, its role in antiviral immunity has not been clearly defined as of yet. Therefore, mice with a targeted defect in the gene encoding this molecule were infected with one
B cell responses to a peptide epitope. VI. The kinetics of antigen recognition modulates B cell-mediated recruitment of T helper subsets.: J Immunol. 1998 Nov 1;161(9):4661-70. Unique Identifier : AIDSLINE MED/99008526; Vijayakrishnan L; Manivel V; Rao KV; Immunology Group, International Centre for Genetic Engineering; and Biotechnology, New Delhi, India.; The ability of Ag-primed B cells to recruit distinct Th subsets was examined using two analogous synthetic peptides, G41CT3 and G28CT3, as model Ags. With sequence differences at only two positions, these peptides were identical both with respect to fine specificity of Abs induced and ability to prime T cells. Lymph n
CD99 engagement on human peripheral blood T cells results in TCR/CD3-dependent cellular activation and allows for Th1-restricted cytokine production.: J Immunol. 1998 Nov 1;161(9):4671-8. Unique Identifier : AIDSLINE MED/99008527; Waclavicek M; Majdic O; Stulnig T; Berger M; Sunder-Plassmann R; Zlabinger GJ; Baumruker T; Stockl J; Ebner C; Knapp W; Pickl WF; Institute of Immunology, University of Vienna, Austria.; We have assessed the functional effect of CD99 engagement on resting human peripheral blood (PB) T cells. CD99, as detected by the mAb 3B2/TA8, is constitutively expressed on all PB T cells and becomes further up-regulated upon cellular activation. In this study we demonstrate that cross-linking of the CD99 molecule w
IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12.: J Immunol. 1998 Nov 1;161(9):4709-18. Unique Identifier : AIDSLINE MED/99008532; Lingnau K; Hoehn P; Kerdine S; Koelsch S; Neudoerfl C; Palm N; Ruede E; Schmitt E; Institute for Immunology, Johannes Gutenberg University, Mainz,; Germany.; IL-4 was found to be the essential differentiation factor for Th2 cells and simultaneously to be a potent inhibitor of Th1 development that is induced by IFN-gamma and IL-12. Furthermore, it was demonstrated that TGF-beta can also inhibit Thl development. In this work, we demonstrate that polyclonal activation of Mel-
The importance of pairwise interactions between peptide residues in the delineation of TCR specificity.: J Immunol. 1998 Nov 1;161(9):4728-35. Unique Identifier : AIDSLINE MED/99008534; Leggatt GR; Hosmalin A; Pendleton CD; Kumar A; Hoffman S; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, Metabolism; Branch, National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892-1578, USA.; A minimal, nonamer epitope (TEMEKEGKI) from the reverse transcriptase protein of HIV-1, restricted by H-2Kk, was identified and the function of individual residues determined. Besides classical anchor residues at positions 2 and 9, methionine at position 3 was identified as an important MHC anchor and improved binding
Mycobacterium avium-intracellulare complex activates nuclear transcription factor-kappaB in different cell types through reactive oxygen intermediates.: J Immunol. 1998 Nov 1;161(9):4834-41. Unique Identifier : AIDSLINE MED/99008547; Giri DK; Mehta RT; Kansal RG; Aggarwal BB; Department of Molecular Oncology, University of Texas M. D.; Anderson Cancer Center, Houston 77030, USA.; Mycobacterium avium-intracellulare complex (MAC) is one of the most common opportunistic pathogens in HIV-infected patients. Their synergistic interaction leads to a rapid deterioration of the host defense. In vivo, MAC manifests as a disseminated granulomatous disease that produces a massive inflammatory tissue respo
Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual.: J Immunol. 1998 Nov 1;161(9):4875-81. Unique Identifier : AIDSLINE MED/99008552; Harrer T; Harrer E; Barbosa P; Kaufmann F; Wagner R; Bruggemann S; Kalden JR; Feinberg M; Johnson RP; Buchbinder S; Walker BD; Department of Medicine III with Institute of Clinical Immunology,; University of Erlangen-Nuremberg, Erlangen, Germany.; Thomas.Harrer@med3.med.uni-erlangen.de; HIV-1 infection has been shown to elicit strong CTL responses in some infected persons, but few data are available regarding the relationship between targeted epitopes and in vivo viral quasispecies. In this study, we examined the CTL response in a person infected for 15 yr with a CD4 count persistently >500 cells/mic
Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.: J Immunol. 1998 Nov 1;161(9):5016-26. Unique Identifier : AIDSLINE MED/99008570; Akwa Y; Hassett DE; Eloranta ML; Sandberg K; Masliah E; Powell H; Whitton JL; Bloom FE; Campbell IL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA.; Type I IFNs, which include IFN-alpha, appear to have complex and broad-ranging actions in the central nervous system (CNS) that may result in protection or injury. To better understand these issues, we generated transgenic mice that produce IFN-alpha1 chronically from astrocytes. These glial fibrillary acidic protein-
Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels.: J Immunol. 1998 Nov 1;161(9):5054-60. Unique Identifier : AIDSLINE MED/99008574; Hofstra CL; Van Ark I; Hofman G; Kool M; Nijkamp FP; Van Oosterhout AJ; Department of Pharmacology and Pathophysiology, Utrecht; University, The Netherlands. C.L.Hofstra@Pharm.UU.NL; Allergic asthma is thought to be regulated by Th2 cells, and inhibiting this response is a promising mode of intervention. Many studies have focused on differentiation of Th cells to the Th1 or Th2 subset in vitro. IL-4 is essential for Th2 development, while IL-12 induces Th1 development, which can be enhanced by IL-
In vivo treatment with a MHC class I-restricted blocking peptide can prevent virus-induced autoimmune diabetes.: J Immunol. 1998 Nov 1;161(9):5087-96. Unique Identifier : AIDSLINE MED/99008578; von Herrath MG; Coon B; Lewicki H; Mazarguil H; Gairin JE; Oldstone MB; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA. matthias@scripps.edu; We tested the in vivo potential of a MHC class I-restricted blocking peptide to sufficiently lower an anti-viral CTL response for preventing virus-induced CTL-mediated autoimmune diabetes (insulin-dependent diabetes mellitus (IDDM)) in vivo without affecting systemic viral clearance. By designing and screening several
Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis.: J Immunol. 1998 Nov 1;161(9):5097-104. Unique Identifier : AIDSLINE MED/99008579; Constantinescu CS; Wysocka M; Hilliard B; Ventura ES; Lavi E; Trinchieri G; Rostami A; Department of Neurology, University of Pennsylvania, Philadelphia; 19104, USA.; Immunization of (PL/J x SJL/J)F1 mice with myelin basic protein (MBP) induces relapsing experimental autoimmune encephalomyelitis (EAE). Relapses occur 7 to 10 days after recovery from the initial paralysis. Staphylococcal enterotoxins (SE) A or B, administered after recovery from the initial paralysis, induce immedia
A cytofluorometric method for the simultaneous detection of both intracellular and surface antigens of apoptotic peripheral lymphocytes.: J Immunol Methods. 1998 Aug 1;217(1-2):11-26. Unique Identifier : AIDSLINE MED/98447466; Lecoeur H; Ledru E; Gougeon ML; Unite d'Oncologie Virale, Departement SIDA et Retrovirus,; Institut Pasteur, Paris, France.; The aim of this study was to define a simple and reliable method to detect simultaneously surface and intracellular antigens in apoptotic peripheral human lymphocytes. This approach requires a permeabilizing procedure for intracellular access of mAbs, which raises the important question of the influence of this proced
A simple and robust method for the complete dissociation of HIV-1 p24 and other antigens from immune complexes in serum and plasma samples.: J Immunol Methods. 1998 Aug 1;217(1-2):143-51. Unique Identifier : AIDSLINE MED/98447479; Steindl F; Armbruster C; Pierer K; Purtscher M; Katinger HW; Institute of Applied Microbiology, University of Agricultural; Sciences, Vienna, Austria. f.steindl@iam.boku.ac.at; Accuracy of antigen determination in human plasma samples is often adversely affected by immune complex formation between antigens (e.g., HIV-1 p24 protein) and specific antibodies. In this study we describe an optimized method for complete immune complex dissociation (ICD) in plasma. This method is based on heat dena
Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells.: J Invest Dermatol. 1998 Oct;111(4):621-8. Unique Identifier : AIDSLINE MED/98435872; Cavani A; Mei D; Guerra E; Corinti S; Giani M; Pirrotta L; Puddu P; Girolomoni G; Laboratory of Immunology, Istituto Dermopatico dell'Immacolata,; IRCCS, Rome, Italy.; To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals. CD4+ T cells purified from peripheral blood of both allergic
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.: J Invest Dermatol. 1998 Oct;111(4):645-9. Unique Identifier : AIDSLINE MED/98435876; Teunissen MB; Koomen CW; de Waal Malefyt R; Wierenga EA; Bos JD; Department of Dermatology, Academic Medical Center, University of; Amsterdam, The Netherlands.; Keratinocytes are influenced by cytokines released by skin-infiltrating T lymphocytes. IL-17 is produced by activated CD4+ T cells and can stimulate epithelial cells. We investigated whether IL-17 could modulate the cytokine production and cell-surface molecule expression of keratinocytes. The effects of IL-17 were co
Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds.: J Invest Dermatol. 1998 Nov;111(5):850-7. Unique Identifier : AIDSLINE MED/99019494; Loots MA; Lamme EN; Zeegelaar J; Mekkes JR; Bos JD; Middelkoop E; Department of Dermatology, Academic Medical Center, University of; Amsterdam, The Netherlands.; In diabetic patients, wound healing is impaired. We studied the pathogenesis behind this clinical observation by characterizing the pattern of deposition of extracellular matrix (ECM) molecules and the cellular infiltrate in chronic (>8 wk) diabetic wounds, compared with chronic venous ulcers and an acute wound healin
Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia.: J Infect Dis. 1998 Oct;178(4):1000-7. Unique Identifier : AIDSLINE MED/99022974; Gendelman HE; Zheng J; Coulter CL; Ghorpade A; Che M; Thylin M; Rubocki R; Persidsky Y; Hahn F; Reinhard J Jr; Swindells S; Center for Neurovirology and Neurodegenerative Disorders,; University of Nebraska Medical Center, Omaha 68198-5400, USA.; A human immunodeficiency virus type 1 (HIV)-seropositive, antiretroviral-naive patient presented with significant cognitive dysfunction. Neuropsychologic, neuroradiologic, immunologic, and virologic studies confirmed HIV-associated dementia (HAD). After 12 weeks of highly active an
Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection.: J Infect Dis. 1998 Oct;178(4):1008-18. Unique Identifier : AIDSLINE MED/99022975; Pontesilli O; Klein MR; Kerkhof-Garde SR; Pakker NG; de Wolf F; Schuitemaker H; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.; To establish correlates of protective immunity during human immunodeficiency virus type 1 (HIV-1) infection, the frequencies of circulating cytotoxic T lymphocyte (CTL) precursors (p) directed against 4 HIV-1 gene products (reverse transcriptase, gag, nef, and env) were evaluated in HIV-1-infected homosexual men who p
Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age.: J Infect Dis. 1998 Oct;178(4):1019-23. Unique Identifier : AIDSLINE MED/99022976; Buseyne F; Janvier G; Teglas JP; Ivanoff S; Burgard M; Bui E; Mayaux MJ; Blanche S; Rouzioux C; Riviere Y; Unite de Virologie et Immunologie Cellulaire, Institut Pasteur,; Paris, France.; The CCR5 gene encodes one of the major human immunodeficiency virus type 1 (HIV-1) coreceptors. A 32-bp deletion in this gene (delta ccr5) is associated with relative resistance to disease progression in heterozygous HIV-1-infected persons. The effect of this mutation on virologic and immunologic parameters was determ
In vivo delayed-type hypersensitivity skin test anergy in human immunodeficiency virus type 1 infection is associated with T cell nonresponsiveness in vitro.: J Infect Dis. 1998 Oct;178(4):1024-9. Unique Identifier : AIDSLINE MED/99022977; Maas JJ; Roos MT; Keet IP; Mensen EA; Krol A; Veenstra J; Schellekens PT; Jurriaans S; Coutinho RA; Miedema F; Department of Public Health and Environment, Academic Medical; Centre, Amsterdam, The Nethrlands. jmaas@gggd.amsterdam.nl; In a cross-sectional study, the prevalence of delayed-type hypersensitivity skin test anergy (DTHA) was examined in 136 asymptomatic human immunodeficiency virus-infected participants in relation to immunologic and virologic parameters. DTHA was assessed with a multitest cell-mediated immunity skin test. Of the 136 pa
Membrane and soluble forms of Fas (CD95) and Fas ligand in peripheral blood mononuclear cells and in plasma from human immunodeficiency virus-infected persons.: J Infect Dis. 1998 Oct;178(4):1030-9. Unique Identifier : AIDSLINE MED/99022978; Hosaka N; Oyaizu N; Kaplan MH; Yagita H; Pahwa S; Department of Pediatrics (Division of Allergy/Immunology), North; Shore University Hospital-New York University School of Medicine,; Manhasset 11030, USA.; The expression of membrane-bound Fas ligand (FasL) and Fas in lymphocytes and monocytes and levels of soluble forms of FasL (sFasL) and Fas (sFas) in plasma from human immunodeficiency virus (HIV)-positive and -negative subjects was evaluated. Surface FasL was detectable on monocytes, but poorly so on lymphocytes, eve
Cross-clade cytotoxic T cell response to human immunodeficiency virus type 1 proteins among HLA disparate North Americans and Thais.: J Infect Dis. 1998 Oct;178(4):1040-6. Unique Identifier : AIDSLINE MED/99022979; Lynch JA; deSouza M; Robb MD; Markowitz L; Nitayaphan S; Sapan CV; Mann DL; Birx DL; Cox JH; Department of Pediatrics, Walter Reed Army Medical Center,; Washington DC, USA.; A globally effective vaccine will need to elicit cytotoxic T lymphocytes (CTL) capable of recognizing diverse human immunodeficiency virus type 1 (HIV-1) clades. Study of the cellular immune responses of HIV-1-infected persons may allow predictions to be made regarding useful vaccine antigen components. The frequency
Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women.: J Infect Dis. 1998 Oct;178(4):1047-52. Unique Identifier : AIDSLINE MED/99022980; Papaevangelou V; Pollack H; Rochford G; Kokka R; Hou Z; Chernoff D; Hanna B; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical; Center-Bellevue Hospital Center, New York 10016, USA.; The transmission of perinatal hepatitis C virus (HCV) infection was studied retrospectively in 62 infants born to 54 HCV- and human immunodeficiency virus (HIV)-coinfected women enrolled in a prospective natural history study of HIV transmission. Infant HCV infection was assessed by nested RNA polymerase chain reactio
Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1.: J Infect Dis. 1998 Oct;178(4):1053-9. Unique Identifier : AIDSLINE MED/99022981; Martin HL Jr; Nyange PM; Richardson BA; Lavreys L; Mandaliya K; Jackson DJ; Ndinya-Achola JO; Kreiss J; Department of Medicine, University of Washington, Seattle; 98104-2499, USA.; To examine associations between method of contraception, sexually transmitted diseases (STDs), and incident human immunodeficiency virus type 1 (HIV-1) infection, a prospective observational cohort study was done among female sex workers attending a municipal STD clinic in Mombasa, Keny
An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection.: J Infect Dis. 1998 Oct;178(4):1060-6. Unique Identifier : AIDSLINE MED/99022982; Mertz KJ; Weiss JB; Webb RM; Levine WC; Lewis JS; Orle KA; Totten PA; Overbaugh J; Morse SA; Currier MM; Fishbein M; St. Louis ME; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; In 1994, an apparent outbreak of atypical genital ulcers was noted by clinicians at the sexually transmitted disease clinic in Jackson, Mississippi. Of 143 patients with ulcers tested with a multiplex polymerase chain reaction (PCR) assay, 56 (39%) were positive for Haemophilus ducreyi, 44 (31%) for herpes simplex vir
Risk factors for primary Pneumocystis carinii pneumonia in human immunodeficiency virus-infected adolescents and adults in the United States: reassessment of indications for chemoprophylaxis.: J Infect Dis. 1998 Oct;178(4):1126-32. Unique Identifier : AIDSLINE MED/99022991; Kaplan JE; Hanson DL; Navin TR; Jones JL; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA. jxk2@cdc.gov; Risk factors for the development of a first episode of Pneumocystis carinii pneumonia (PCP) were investigated in the Adult and Adolescent Spectrum of Disease Project, a medical record review study involving longitudinal follow-up of human immunodeficiency virus-infected adults in 9 US cities. Risk factors included dec
Glycoprotein B subtyping of cytomegalovirus (CMV) in the vitreous of patients with AIDS and CMV retinitis.: J Infect Dis. 1998 Oct;178(4):1149-53. Unique Identifier : AIDSLINE MED/99022995; Chern KC; Chandler DB; Martin DF; Kuppermann BD; Wolitz RA; Margolis TP; Francis I. Proctor Foundation, UCSF Medical Center 94143-0944,; USA.; A 550-bp region of the cytomegalovirus ( CMV ) glycoprotein B (gB) gene was amplified by polymerase chain reaction (PCR) from 141 vitreous specimens of 120 patients with AIDS and CMV retinitis from three different metropolitan
Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha.: J Infect Dis. 1998 Oct;178(4):1158-62. Unique Identifier : AIDSLINE MED/99022997; Weiss L; Roux A; Garcia S; Demouchy C; Haeffner-Cavaillon N; Kazatchkine MD; Gougeon ML; INSERM U430, Hopital Broussais, Paris, France.; laurence.weiss@brs.ap-hop-paris.fr; The present study describes the persistent expansion of a subpopulation of circulating double-positive CD4+CD8+ T cells in a human immunodeficiency virus (HIV)-infected person over 8 years. The percentage of double-positive cells was remarkably stable with time and was not related to HIV plasma virus load. CD4+CD8+ ce
A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness.: J Infect Dis. 1998 Oct;178(4):1163-6. Unique Identifier : AIDSLINE MED/99022998; Wilkinson DA; Operskalski EA; Busch MP; Mosley JW; Koup RA; Department of Medicine, University of Texas Southwestern Medical; Center, Dallas 75235-9113, USA. dwilki@mednet.swmed.edu; The beta-chemokine receptor CCR5 is required as a coreceptor by non-syncytium-inducing (NSI) strains of human immunodeficiency virus type 1 (HIV-1). NSI viruses predominate early during an infection and are thought to be important for the transmission of HIV-1. The importance of CCR5 during parenteral transmission of
Changes in lymphocyte subsets in human immunodeficiency virus-positive persons with < 5 CD4 T lymphocytes/mm3.: J Infect Dis. 1998 Oct;178(4):1166-9. Unique Identifier : AIDSLINE MED/99022999; Sabin CA; Mocroft A; Bofill M; Janossy G; Lee CA; Johnson M; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital and School of Medicine, London, United Kingdom.; caroline@rfhsm.ac.uk; All patients seen at the Royal Free Hospital, London, who had at least one CD4 T lymphocyte count of
Coadministration of zidovudine and interleukin-2 increases absolute CD4 cells in subjects with Walter Reed stage 2 human immunodeficiency virus infection: results of ACTG protocol 042.: J Infect Dis. 1998 Oct;178(4):1170-3. Unique Identifier : AIDSLINE MED/99023000; Bartlett JA; Berend C; Petroni GR; Ottinger J; Tyler DL; Pettinelli C; Weinhold KJ; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, 27710, USA.; Interleukin-2 ( IL-2 ) can increase numbers of absolute CD4 cells in persons infected with the human immunodeficiency virus who are receiving antiretroviral therapy. Twenty-five subjects with > 400/mm3 absolute CD4 cells received zidovudine and low-dose intravenous or su
Sexually transmitted disease acquisition among women infected with human immunodeficiency virus type 1.: J Infect Dis. 1998 Oct;178(4):1174-7. Unique Identifier : AIDSLINE MED/99023001; Bersoff-Matcha SJ; Horgan MM; Fraser VJ; Mundy LM; Stoner BP; Washington University School of Medicine, Department of Internal; Medicine (Infectious Disease Division), St. Louis, Missouri; 63110, USA.; Recent evidence suggests that sexually transmitted diseases (STDs) enhance the transmission of human immunodeficiency virus (HIV) type 1. In 143 HIV-infected women enrolled in a university-based longitudinal HIV clinic over 16 months (mean), the STD point prevalence was examined at enrollment and the cumulative preval
The prevalence of measles antibody in human immunodeficiency virus-infected patients in northern California.: J Infect Dis. 1998 Oct;178(4):1177-80. Unique Identifier : AIDSLINE MED/99023002; Kemper CA; Gangar M; Arias G; Kane C; Deresinski SC; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, California 95128, USA.; The seroprevalence of measles (rubeola) antibody in 619 human immunodeficiency virus (HIV)-infected adults was determined by a standard ELISA. Risk factors for a lack of antibody and presumed susceptibility to measles were examined. Whereas overall, 9.8% of patients (60) were found to lack antibody, 17.8% of those bor
The presence of active hepatitis C virus replication in lymphoid tissue in patients coinfected with human immunodeficiency virus type 1.: J Infect Dis. 1998 Oct;178(4):1189-92. Unique Identifier : AIDSLINE MED/99023005; Laskus T; Radkowski M; Wang LF; Vargas H; Rakela J; Division of Transplantation Medicine, University of Pittsburgh; Medical Center, Pennsylvania 15213, USA.; The existence of extrahepatic replication sites of hepatitis C virus (HCV) remains controversial. Highly strand-specific Tth-based reverse transcriptase-polymerase chain reaction was used to search for the presence of viral RNA negative strand in lymph nodes from 16 patients with AIDS and in peripheral blood mononucle
Enhanced induction of interleukin-12(p40) secretion by human macrophages infected with Mycobacterium avium complex isolates from disseminated infection in AIDS patients.: J Infect Dis. 1998 Oct;178(4):1209-12. Unique Identifier : AIDSLINE MED/99023010; von Grunberg PW; Plum G; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat zu Koln, Germany.; Interleukin-12 (IL-12) is a key cytokine in the immune response to infection with Mycobacterium avium complex (MAC). Human immunodeficiency virus infection, a predisposing factor for disseminated MAC infection, causes a drop of bioactive IL-12(p70), mainly by decreasing the constitutive production of p35. IL-12(p40) a
Convulsions due to increased permeability of the blood-brain barrier in experimental cerebral malaria can be prevented by splenectomy or anti-T cell treatment.: J Infect Dis. 1998 Oct;178(4):1225-7. Unique Identifier : AIDSLINE MED/99023014; Hermsen CC; Mommers E; van de Wiel T; Sauerwein RW; Eling WM; Department of Medical Microbiology, University of Nijmegen, The; Netherlands. R.HERMSEN@MMB.AZN.NL; Experimental cerebral malaria (ECM) can be induced in C57B1 mice by infection with Plasmodium berghei K173 parasites. Behavioral changes shortly before they die of ECM may reflect disturbance of the integrity of the blood-brain barrier (BBB). Folic acid elicits strong convulsive activity if the permeability of the BBB
Neurosyphilis during the AIDS epidemic, New Orleans, 1990-1997 [letter]: J Infect Dis. 1998 Oct;178(4):1229. Unique Identifier : AIDSLINE MED/99023016; Inungu J; Morse A; Gordon C
Does the capsule component of the Cryptococcus neoformans glucuronoxylomannan impair transendothelial migration of leukocytes in patients with cryptococcal meningitis? [letter]: J Infect Dis. 1998 Oct;178(4):1231-2. Unique Identifier : AIDSLINE MED/99023018; Lipovsky MM; van Elden LJ; Walenkamp AM; Dankert J; Hoepelman AI
Maternal-fetal feline immunodeficiency virus transmission: timing and tissue tropisms.: J Infect Dis. 1998 Oct;178(4):960-7. Unique Identifier : AIDSLINE MED/99022969; Rogers AB; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523-1671, USA.; The feline immunodeficiency virus (FIV) model of vertical human immunodeficiency virus type 1 transmission was used to explore the timing and tissue tropisms associated with intrauterine lentivirus infection. Cats chronically infected with FIV-B-2542 and their cesarean-derived fetuses and placentas were assayed by pol
The CD8+ cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain.: J Infect Dis. 1998 Oct;178(4):968-77. Unique Identifier : AIDSLINE MED/99022970; Bucci JG; Gebhard DH; Childers TA; English RV; Tompkins MB; Tompkins WA; College of Veterinary Medicine, North Carolina State University,; Raleigh 27606, USA.; The acute stage of feline immunodeficiency virus (FIV) infection is characterized by a CD8+ anti-FIV response that parallels the appearance of a CD8+ subpopulation with reduced expression of the beta chain (CD8 alpha + beta lo). The relationship between the CD8 alpha + beta lo phenotype and CD8+ anti-FIV activity was
Herpes simplex virus shedding among human immunodeficiency virus-negative men who have sex with men: site and frequency of shedding.: J Infect Dis. 1998 Oct;178(4):978-82. Unique Identifier : AIDSLINE MED/99022971; Krone MR; Tabet SR; Paradise M; Wald A; Corey L; Celum CL; Department of Biostatistics, University of Washington, Seattle,; USA.; The frequency and anatomic location of subclinical and symptomatic herpes simplex virus (HSV) shedding were evaluated among human immunodeficiency virus (HIV)-negative HSV-2-seropositive men who have sex with men (MSM). Eight men attended a research clinic daily for 30 days for a detailed genital examination and anosc
Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle.: J Infect Dis. 1998 Oct;178(4):983-91. Unique Identifier : AIDSLINE MED/99022972; Mostad SB; Jackson S; Overbaugh J; Reilly M; Chohan B; Mandaliya K; Nyange P; Ndinya-Achola J; Bwayo JJ; Kreiss JK; Department of Epidemiology, University of Washington, Seattle; 98195, USA.; Cervical and vaginal secretions from 17 women infected with human immunodeficiency virus type 1 (HIV-1) were evaluated daily through the course of one menstrual cycle for HIV-1 DNA (21-31 visits per woman). HIV-1-infected cells were detected in 207 (46%) of 450 endocervical swabs and 74 (16%) of 449 vaginal swabs. The
Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: a randomized, controlled, multicenter study. Australian IL-2 Study Group.: J Infect Dis. 1998 Oct;178(4):992-9. Unique Identifier : AIDSLINE MED/99022973; Carr A; Emery S; Lloyd A; Hoy J; Garsia R; French M; Stewart G; Fyfe G; Cooper DA; HIV Medicine Unit, St Vincent's Hospital, Sydney, Australia.; acarr@stvincents.com.au; The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2 ) or a slow-release, polyethylene glycol (PEG)-modified IL-2 were studied in human immunodeficiency virus (HIV)-infected persons with CD4 cell counts between 200 and 500/mm3. One
Palliative care in the acute hospital setting.: J Neurosci Nurs. 1998 Jun;30(3):200-4. Unique Identifier : AIDSLINE MED/98354037; Adelstein W; Burton S; Sunrise Hospital and Medical Center, Sunrise Children's Hospital; in Las Vegas, Nevada, USA.; Palliative care, associated with the hospice movement, has achieved wide acceptance in many countries. Its focus has been care of cancer patients and more recently, those with AIDS. Most acute hospitals do not have avenues to care for these patients or others in the end of life stages. One method of providing care and
A gene therapy approach to treatment of autoimmune disease.: Immunol Res. 1998 Aug;18(1):15-26. Unique Identifier : AIDSLINE MED/98392058; Seroogy CM; Fathman CG; Department of Medicine, Stanford University School of Medicine,; CA 94305-5111, USA. cseroogy@leland.stanford.edu; New insights into the underlying mechanisms for the development of autoimmune diseases in humans and various animal models continue to increase with our understanding of factors that drive polarization of T helper (Th) responses and tolerance. This information has led to the development of new treatment strategies, in
Intestinal intraepithelial T lymphocytes. Our T cell horizons are expanding.: Immunol Res. 1998 Aug;18(1):41-53. Unique Identifier : AIDSLINE MED/98392060; Nanno M; Kanamori Y; Saito H; Kawaguchi-Miyashita M; Shimada S; Ishikawa H; Yakult Central Institute for Microbiological Research, Tokyo,; Japan.; The alimentary tract is an essential structure for the ingesting of nutrients from the outside, and even most primitive animals have a straight tract that runs from the mouth to the anus. We come into contact with the outside world through our skin and mucous membranes. The surface area of the enteric mucous membrane,
Impaired phagocyte oxidative capacity in patients with human immunodeficiency virus infection.: J Lab Clin Med. 1998 Oct;132(4):284-93. Unique Identifier : AIDSLINE MED/99008830; Pitrak DL; Mullane KM; Bilek ML; Stevens P; Allen RC; Department of Medicine, University of Illinois College of; Medicine at Chicago and West Side Veterans Administration Medical; Center, USA.; Bacterial infections that may be related to impaired phagocyte function often develop in patients infected with human immunodeficiency virus (HIV). We examined the oxidative capacity of circulating phagocytes in 78 HIV+ patients and 31 control subjects by measuring chemiluminescence with a whole blood assay. Phagocyte
Glycocalicin levels in the plasma of HIV+ patients: an indicator of platelet turnover.: J Lab Clin Med. 1998 Oct;132(4):303-7. Unique Identifier : AIDSLINE MED/99008832; Williams SB; Sano M; Smith N; Horne M; Yarchoan R; Wyvill K; Zeichner S; Taylor P; Knudson T; Gralnick HR; Warren G. Magnuson Clinical Center and the HIV and Aids; Malignancy Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland 20892, USA.; Glycocalicin (GC) is the carbohydrate-rich portion of platelet membrane glycoprotein Ib(alpha) that can be cleaved from circulating platelets by proteases. The plasma GC level is an indicator of platelet turnover. Using an ELISA for GC, we assayed the plasma of 20 normal children (age 6 to 13 years), 50 HIV+ children
Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment.: J Leukoc Biol. 1998 Oct;64(4):503-10. Unique Identifier : AIDSLINE MED/98438021; Roos A; Schilder-Tol EJ; Weening JJ; Aten J; Department of Pathology, Academic Medical Center, University of; Amsterdam, The Netherlands.; CD134 (OX40) is involved in T cell costimulation and T cell-dependent antibody production. We show strongly increased T cell expression of CD134 in a model of T helper 2-mediated systemic autoimmunity, induced by HgCl2. Regulation of CD134 expression on CD4+ T cells was further studied in vitro, identifying CD134 as a
Effects of fish oil on cytokines and immune functions of mice with murine AIDS.: J Lipid Res. 1998 Aug;39(8):1677-87. Unique Identifier : AIDSLINE MED/98381829; Xi S; Cohen D; Chen LH; Nutritional Sciences Program, University of Kentucky, Lexington; 40506-0054, USA.; The effects of fish oil, which is rich in n-3 fatty acids, on cytokine levels in a murine model of acquired immune deficiency syndrome (AIDS) were studied. Thirty-two C57BL/6 female mice were divided into two dietary groups and fed either a corn oil diet or a fish oil diet. After 4 weeks, each diet group was further d
Anonymous unlinked testing as a sentinel approach: experience in Germany.: J Epidemiol Community Health. 1998 Apr;52 Suppl 1:25S-27S. Unique Identifier : AIDSLINE MED/98436758; Siedler A; Hamouda O; Schwartlander B; Robert Koch-Institut, Berlin, Germany.; STUDY OBJECTIVE: To establish a laboratory sentinel as a supplementary instrument for monitoring the seroprevalence of HIV among childbearing women as a proxy to the heterosexually active population. DESIGN/SETTING: Anonymous unlinked testing of neonatal dried blood spots has been performed in central laboratories of
Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication.: J Exp Med. 1998 Oct 5;188(7):1255-65. Unique Identifier : AIDSLINE MED/98438575; Honda Y; Rogers L; Nakata K; Zhao BY; Pine R; Nakai Y; Kurosu K; Rom WN; Weiden M; Division of Pulmonary and Critical Care Medicine and Bellevue; Chest Service, New York University Medical Center, New York; 10016, USA.; We have previously observed that HIV-1 replication is suppressed in uninflamed lung and increased during tuberculosis. In vitro THP-1 cell-derived macrophages inhibited HIV-1 replication after infection with Mycobacterium tuberculosis. Suppression of HIV-1 replication was associated with inhibition of the HIV-1 long t
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.: J Exp Med. 1998 Oct 5;188(7):1333-42. Unique Identifier : AIDSLINE MED/98438582; Liu Q; Oliveira-Dos-Santos AJ; Mariathasan S; Bouchard D; Jones J; Sarao R; Kozieradzki I; Ohashi PS; Penninger JM; Dumont DJ; Amgen Institute, Toronto, Ontario, Canada M5G 2C1. qliu@amgen.com; Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which has been implicated as an important signaling molecule in hematopoietic cells. In B cells, Ship becomes associated with Fcgamma receptor IIB (FcgammaRIIB), a low affinity receptor for the Fc portion of immunoglobulin (Ig)G, and is r
A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.: J Exp Med. 1998 Oct 5;188(7):1343-52. Unique Identifier : AIDSLINE MED/98438583; Douni E; Kollias G; Department of Molecular Genetics, Hellenic Pasteur Institute, 115; 21 Athens, Hellas.; Despite overwhelming evidence that enhanced production of the p75 tumor necrosis factor receptor (p75TNF-R) accompanies development of specific human inflammatory pathologies such as multi-organ failure during sepsis, inflammatory liver disease, pancreatitis, respiratory distress syndrome, or AIDS, the function of thi
Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.: J Exp Med. 1998 Oct 19;188(8):1485-92. Unique Identifier : AIDSLINE MED/99000669; Xu D; Chan WL; Leung BP; Hunter D; Schulz K; Carter RW; McInnes IB; Robinson JH; Liew FY; Department of Immunology, University of Glasgow, Glasgow G11 6NT,; United Kingdom.; Interleukin (IL)-18 induces interferon (IFN)-gamma synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell development. We report here that IL-18 receptor (IL-18R) is selectively expressed on murine Th1 but not Th2 cells. IL-18R mRNA was expressed constitutively and consistently in long-term cult
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue.: J Exp Med. 1998 Oct 19;188(8):1493-501. Unique Identifier : AIDSLINE MED/99000670; Ludewig B; Odermatt B; Landmann S; Hengartner H; Zinkernagel RM; Institute of Experimental Immunology, University of Zurich,; CH-8091, Zurich, Switzerland. ludewigb@pathol.unizh.ch; Activation of autoreactive T cells can lead to autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM). The initiation and maintenance of IDDM by dendritic cells (DC), the most potent professional antigen-presenting cells, were investigated in transgenic mice expressing the lymphocytic choriomeningitis
Cost of preventing HIV infection after sexual exposure.: J Fam Pract. 1998 Oct;47(4):251-2. Unique Identifier : AIDSLINE MED/99005934; Lindbloom EJ; Stevermer JJ; University of Missouri, Columbia, USA.; lindbloome@health.missouri.edu
The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses.: J Gen Virol. 1998 Oct;79 ( Pt 10):2381-91. Unique Identifier : AIDSLINE MED/98451323; Hultgren C; Milich DR; Weiland O; Sallberg M; Division of Clinical Virology, Huddinge University Hospital,; Sweden.; Ribavirin is effective in combination therapies against chronic hepatitis C virus (HCV) infection, although its direct antiviral properties are unclear. We therefore studied the immune-modulatory effects of ribavirin on hepatitis B virus (HBV)- and HCV-specific immune responses. During a 24 week placebo-controlled rib
Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent.: J Gen Virol. 1998 Oct;79 ( Pt 10):2447-53. Unique Identifier : AIDSLINE MED/98451330; Tokunaga K; Kojima A; Kurata T; Ikuta K; Akari H; Koyama AH; Kawamura M; Inubushi R; Shimano R; Adachi A; Department of Pathology, National Institute of Infectious; Diseases, Tokyo, Japan.; The growth kinetics of wild-type and nef mutant viruses of human immunodeficiency virus type 1 were comparatively analysed in several human CD4+ cell lines. Delayed replication of nef mutant virus was observed in all cell lines examined. To determine the stage in the virus replication cycle that is affected by Nef, a
Human immunodeficiency virus type 1 in faeces and serum: evidence against independently evolving subpopulations.: J Gen Virol. 1998 Oct;79 ( Pt 10):2455-9. Unique Identifier : AIDSLINE GENBANK/AF034408; van der Hoek L; Goudsmit J; Maas J; Sol CJ; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands. L.VANDERHOEK@AMC.UVA.NL; It is not known whether independent tissue-specific evolution accounts for the differences between human immunodeficiency virus type 1 (HIV-1) subpopulations in intestinal tissue and blood. To study this, sequential serum samples from three persons were analysed for the presence of HIV-1 V3 genotypes which were detect
Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression.: J Gen Virol. 1998 Oct;79 ( Pt 10):2461-7. Unique Identifier : AIDSLINE MED/98451332; Dykhuizen M; Mitchen JL; Montefiori DC; Thomson J; Acker L; Lardy H; Pauza CD; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715, USA.; Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (P
Human Th1 and Th2 T-cell clones are equally susceptible to infection and immortalization by human T-lymphotropic virus type I.: J Gen Virol. 1998 Oct;79 ( Pt 10):2469-74. Unique Identifier : AIDSLINE MED/98451333; Macchi B; Grelli S; Matteucci C; D'Elios MM; De Carli M; Favalli C; Del Prete G; Mastino A; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.; Human CD4+ Th1 and Th2 clones were infected with human T-lymphotropic virus type I (HTLV-I) and followed up for a 12 month period in culture. PCR analysis showed that proviral DNA and viral mRNA were present in both Th1 and Th2 infected clones, throughout the entire culture period. Thus, HTLV-I exhibited neither prefe
HTLV-I associated primary CNS T-cell lymphoma.: J Neurol Sci. 1998 Jun 30;158(2):226-31. Unique Identifier : AIDSLINE MED/98368078; Marshall AG; Pawson R; Thom M; Schutz TF; Scaravilli F; Rudge P; National Hospital for Neurology and Neurosurgery, London, UK.; Primary T-cell lymphoma of the central nervous system (CNS) is an extremely rare tumour. The Human T-cell lymphoma virus type 1 associated Adult T-cell lymphoma/leukaemia (ATLL) often involves the CNS during its course but disease limited to the CNS is exceptional. Using clinicopathological and molecular biological in
Structure-based design of ligands for protein basic domains: application to the HIV-1 Tat protein.: J Comput Aided Mol Des. 1998 May;12(3):229-40. Unique Identifier : AIDSLINE MED/98421209; Filikov AV; James TL; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446, USA.; A methodology has been developed for designing ligands to bind a flexible basic protein domain where the structure of the domain is essentially known. It is based on an empirical binding free energy function developed for highly charged complexes and on Monte Carlo simulations in internal coordinates with both the lig
PAPQMD parametrization of molecular systems with cyclopropyl rings: conformational study of homopeptides constituted by 1-aminocyclopropane-1-carboxylic acid.: J Comput Aided Mol Des. 1998 May;12(3):259-73. Unique Identifier : AIDSLINE MED/98421211; Aleman C; Casanovas J; Galembeck SE; Departament d'Enginyeriia Quimica, E.T.S. d'Enginyers; Industrials, Universitat Politecnica de Catalunya, Barcelona,; Spain.; The suitability of ab initio, semiempirical and density functional methods as sources of stretching and bending parameters has been explored using the PAPQMD (Program for Approximate Parametrization from Quantum Mechanical Data) strategy. Results show that semiempirical methods provide parameters comparable to those c
Phase II trial of liposomal daunorubicin in the treatment of AIDS-related pulmonary Kaposi's sarcoma.: J Clin Oncol. 1998 Oct;16(10):3369-74. Unique Identifier : AIDSLINE MED/98450994; Tulpule A; Yung RC; Wernz J; Espina BM; Myers A; Scadden DT; Cabriales S; Ilaw M; Boswell W; Gill PS; Department of Medicine, Kenneth Norris Cancer Hospital and; Research Institute, University of Southern California School of; Medicine, Los Angeles 90033, USA.; PURPOSE: Kaposi s sarcoma (KS) is the most common tumor in patients with AIDS and can be fatal in patients with lung involvement. Systemic chemotherapy is the most effective treatment for pulmonary KS. We thus conducted this study to determine the efficacy of liposomal daunorubicin in the treatment of patients with pu
Forty-six-year-old man with unexplained hematuria, proteinuria, and pulmonary infiltrates: a clinicopathologic correlation conference from the University of Oklahoma College of Medicine.: J Okla State Med Assoc. 1998 Oct;91(7):399-405. Unique Identifier : AIDSLINE MED/99009673; Lee S; Walter M; Reichlin M; Silva F; Department of Medicine, University of Oklahoma Health Sciences; Center, Oklahoma City, USA.
A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy-naive HIV-1 infection. The Pediatric AIDS Clinical Trials Group Protocol 300 Study Team.: J Pediatr. 1998 Oct;133(4):500-8. Unique Identifier : AIDSLINE MED/99003955; McKinney RE Jr; Johnson GM; Stanley K; Yong FH; Keller A; O'Donnell KJ; Brouwers P; Mitchell WG; Yogev R; Wara DW; Wiznia A; Mofenson L; McNamara J; Spector SA; Department of Pediatrics and Psychiatry, Duke University Medical; Center, Durham, North Carolina 27710, USA.; OBJECTIVE: The Pediatric AIDS Clinical Trials Group (PACTG) Protocol 300 assessed the clinical efficacy and safety of combination zidovudine/lamivudine (ZDV/ 3TC ) compared with either didanosine (ddI) alone or combination ZDV/ddI. STUDY DESIGN: Childre
Alterations of Toxoplasma gondii induced by 2',3'-dideoxyinosine in vitro.: J Parasitol. 1998 Oct;84(5):1055-9. Unique Identifier : AIDSLINE MED/99008788; Sarciron ME; Lawton P; Petavy AF; Peyron F; Department of Parasitology and Medical Mycology, Claude Bernard; University, Lyon, France.; The time-course of action of the antiviral agent 2 ,3 -dideoxyinosine (ddI) against Toxoplasma gondii tachyzoites in vitro and its effects at the ultrastructural level were investigated. The very short latency of effect and high efficacy of ddI were evidenced by the fact that the drugs effects on parasite growth occu
Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo.: J Pharm Sci. 1998 Oct;87(10):1184-9. Unique Identifier : AIDSLINE MED/98432950; von Moltke LL; Greenblatt DJ; Duan SX; Daily JP; Harmatz JS; Shader RI; Department of Pharmacology and Experimental Therapeutics,; Division of Clinical Pharmacology, Tufts University School of; Medicine Boston, Massachusetts 02111, USA.; Lvonmoltke@infonet.tufts.edu; Pharmacokinetic drug interactions with viral protease inhibitors are of potential clinical importance. An in vitro model was applied to the quantitative identification of possible interactions of protease inhibitors with substrates of cytochrome P450-2D6. Biotransfo
Characterization of plantar verrucae among individuals with human immunodeficiency virus.: J Am Podiatr Med Assoc. 1998 Sep;88(9):442-5. Unique Identifier : AIDSLINE MED/98443875; Meberg R; Kenyon E; Bierman R; Loveland L; Barbosa P; California College of Podiatric Medicine, San Francisco, USA.; Plantar verrucae, caused by human papillomavirus (HPV), are commonly found in patients who have tested positive for the antibodies to human immunodeficiency virus (HIV). A better understanding of the characteristics of plantar verrucae in HIV+ patients in needed. A pilot study was conducted concentrating on three char
Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A.: J Pharmacol Exp Ther. 1998 Oct;287(1):381-8. Unique Identifier : AIDSLINE MED/98438650; Voorman RL; Maio SM; Payne NA; Zhao Z; Koeplinger KA; Wang X; Drug Metabolism and Disposition Research, Pharmacia and Upjohn,; Kalamazoo, Michigan, USA. Richard.L.Voorman@am.pnu.com; Administration of delavirdine , an HIV-1 reverse transcriptase inhibitor, to rats or monkeys resulted in apparent loss of hepatic microsomal CYP3A and delavirdine desalkylation activity. Human CYP3A catalyzes the formation of desalkyl delavirdine and 6
Safer-sex education for persons with mental illness.: J Psychosoc Nurs Ment Health Serv. 1998 Aug;36(8):33-7. Unique Identifier : AIDSLINE MED/98394147; Hajagos K; Geiser P; Parker B; Tesfa A; Nursing Service, Research, Department of Veterans Affairs Medical; Center, Northport, New York 11768, USA.; 1. Safer-sex education is crucial for controlling the spread of HIV and this education is within the realm of nursing practice. 2. Safer-sex education for persons with mental illness must include repetitive, interactive education capitalizing on verbal, visual, written, tactile, and motor skill teaching methods to com
[Renal insufficiency with AIDS: ultrasonographic aspects]: J Radiol. 1998 Apr;79(4):323-6. Unique Identifier : AIDSLINE MED/98429814; N'Gbesso RD; Vakou D; Keita AK; Service de Radiologie, CHU de Yopougon, Abidjan.; Renal pathologic changes in AIDS involve various factors and can also occur in several other forms of renal disease. Renal sonography was prospectively performed in 31 patients with laboratory evidence of AIDS and renal insufficiency. All patients included in this study were without clinical manifestations (group II o
A randomized, double blind, placebo controlled multicenter trial of murine anti-CD4 monoclonal antibody therapy in rheumatoid arthritis.: J Rheumatol. 1998 Aug;25(8):1457-61. Unique Identifier : AIDSLINE MED/98375901; Wendling D; Racadot E; Wijdenes J; Sibilia J; Flipo RM; Cantagrel A; Miossec P; Eschard JP; Macro M; Bertin P; Liote F; Debiais F; Juvin R; Le Goff P; Masson C; Service de Rhumatologie, CHU Besancon, France.; OBJECTIVE: To assess safety and efficacy of a murine anti-CD4 monoclonal antibody (Mab) in a population of patients with rheumatoid arthritis (RA) compared to treatment with placebo. METHODS: Fifty-eight patients with defined RA were included in this placebo controlled, randomized, double blind, multicenter study. Of
CC chemokine receptor 5 polymorphism in rheumatoid arthritis.: J Rheumatol. 1998 Aug;25(8):1462-5. Unique Identifier : AIDSLINE MED/98375902; Garred P; Madsen HO; Petersen J; Marquart H; Hansen TM; Freiesleben Sorensen S; Volck B; Svejgaard A; Andersen V; Department of Clinical Immunology, The National University; Hospital (Rigshospitalet), Copenhagen, Denmark.; Garred@post5.tele.dk; OBJECTIVE: Some chemokine receptors have been shown to be co-receptors for human immunodeficiency virus (HIV-1). A 32 base pair deletion allele in the CC chemokine receptor 5 gene (CCR5 delta32 allele) affects both transmission of HIV-1 and acquired immunodeficiency syndrome (AIDS)-free survival. Chemokines are sugges
Analysis of type 1 and type 2 T cells in synovial fluid and peripheral blood of patients with rheumatoid arthritis.: J Rheumatol. 1998 Aug;25(8):1466-71. Unique Identifier : AIDSLINE MED/98375903; Kusaba M; Honda J; Fukuda T; Oizumi K; First Department of Internal Medicine, Kurume University School; of Medicine, Fukuoka, Japan.; OBJECTIVE: It has been reported that CD4+ helper T cells play an important role in the pathogenesis of rheumatoid arthritis (RA). We evaluated the presence of intracellular cytokines interleukin 4 (IL-4) and interferon-gamma (IFN-gamma) produced by CD4+ and CD8+ T cells in the synovial fluid and peripheral blood of pa
Spondyloarthropathy and human immunodeficiency virus infection in Zambia.: J Rheumatol. 1998 Aug;25(8):1553-9. Unique Identifier : AIDSLINE MED/98375918; Njobvu P; McGill P; Kerr H; Jellis J; Pobee J; Department of Medicine, University Teaching Hospital, Lusaka,; Zambia.; OBJECTIVE: To explore the relationship between spondyloarthropathy (SpA) and infection with the human immunodeficiency virus (HIV) in black Zambians. METHODS: Consecutive patients attending an arthritis clinic in a 30 month period were assessed clinically and tested for the presence of antibodies to HIV. HLA-B27 gene
Identification of Th subsets in juvenile rheumatoid arthritis confirmed by intracellular cytokine staining [letter]: J Rheumatol. 1998 Aug;25(8):1651-3. Unique Identifier : AIDSLINE MED/98375936; Ozen S; Tucker LB; Miller LC
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.: J Med Chem. 1998 Oct 8;41(21):3948-60. Unique Identifier : AIDSLINE MED/98440452; Artico M; Di Santo R; Costi R; Novellino E; Greco G; Massa S; Tramontano E; Marongiu ME; De Montis A; La Colla P; Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di; Studi Farmaceutici, Universita di Roma "La Sapienza", Piazzale; A. Moro 5, I-00185 Roma, Italy.; Various cinnammoyl-based structures were synthesized and tested in enzyme assays as inhibitors of the HIV-1 integrase (IN). The majority of compounds were designed as geometrically or conformationally constrained analogues of caffeic acid phenethyl ester (CAPE) and were characterized by a syn disposition of the carbon
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.: J Med Chem. 1998 Oct 8;41(21):4109-17. Unique Identifier : AIDSLINE MED/98440466; Arranz E; Diaz JA; Ingate ST; Witvrouw M; Pannecouque C; Balzarini J; De Clercq E; Vega S; Instituto de Quimica Medica, CSIC, Juan de la Cierva, 3, 28006; Madrid, Spain, and Rega Institute for Medical Research,; Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.; The 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs) represent a recently discovered chemical class of non-nucleoside reverse transcriptase inhibitors that selectively block human immunodeficiency virus type 1 replication. In a search for a better understanding of their mode of binding and with the aim of ob
Infections in children. Proceedings of the 4th Liverpool School of Tropical Medicine and Bayer Symposium on Microbial Disease.: J Med Microbiol. 1998 Nov;47(11):943-82. Unique Identifier : AIDSLINE MED/99038089; Hart CA; Smyth RL; Duerden BI; Department of Medical Microbiology, University of Liverpool.
Use of PCR to detect mycoplasma DNA in respiratory tract specimens from adult HIV-positive patients.: J Med Microbiol. 1998 Nov;47(11):983-6. Unique Identifier : AIDSLINE MED/99038090; Cultrera R; Roulland-Dussoix D; Romani R; Contini C; Department of Clinical and Experimental Medicine, University of; Ferrara, Italy.; The polymerase chain reaction (PCR) was evaluated retrospectively for its ability to detect Ureaplasma urealyticum and Mycoplasma spp. in respiratory tract specimens obtained from adult patients with AIDS. Mycoplasma DNA was detected in specimens from 12 of 84 patients. Of the 107 specimens tested, 13 and seven positi
Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys.: J Med Primatol. 1998 Apr-Jun;27(2-3):104-12. Unique Identifier : AIDSLINE MED/98418747; Gold LH; Fox HS; Henriksen SJ; Buchmeier MJ; Weed MR; Taffe MA; Huitron-Resendiz S; Horn TF; Bloom FE; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California 92037, USA. lgold@scripps.edu; A model is proposed in which a neurovirulent, microglial-passaged, simian immunodeficiency virus (SIV) is used to produce central nervous system (CNS) pathology and behavioral deficits in rhesus monkeys reminiscent of those seen in humans infected with human immunodeficiency virus (HIV). The time course of disease pro
Expression and in vitro evaluation of rhesus macaque wild type (wt) and modified CC chemokines.: J Med Primatol. 1998 Apr-Jun;27(2-3):113-20. Unique Identifier : AIDSLINE MED/98418748; Bostik P; Villinger F; Brice GT; Chikkala NF; Brar SS; Cruikshank WW; Adams JW; Hillyer CD; Ansari AA; Department of Pathology and Laboratory Medicine and the Winship; Cancer Center, Emory University School of Medicine, Atlanta,; Georgia 30322, USA.; Several human CC chemokines have been shown to inhibit HIV/ SIV infection in vitro, providing the rationale for their potential use in vivo. However, because of their inherent physiological effect, such chemokines are reasoned to be of limited therapeutic value due to potential side effects. The knowledge that amino t
Dendritic cells from skin and blood of macaques both promote SIV replication with T cells from different anatomical sites.: J Med Primatol. 1998 Apr-Jun;27(2-3):121-8. Unique Identifier : AIDSLINE MED/98418749; Ignatius R; Isdell F; O'Doherty U; Pope M; Laboratory of Cellular Physiology and Immunology, The Rockefeller; University, New York, New York, USA.; The SIV-macaque system offers the opportunity to study the pathogenesis and immune aspects of a primate retroviral infection in which immunodeficiency also develops, much like HIV infection in humans. Since it is known that human dendritic cells (DCs) are involved in HIV replication, mature cytokine-generated DCs obta
Intracellular cytokine expression in the CD4+ and CD8+ T cells from intestinal mucosa of simian immunodeficiency virus infected macaques.: J Med Primatol. 1998 Apr-Jun;27(2-3):129-40. Unique Identifier : AIDSLINE MED/98418750; Smit-McBride Z; Mattapallil JJ; Villinger F; Ansari AA; Dandekar S; Department of Internal Medicine, University of California at; Davis 95616, USA.; Isolated intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL) from jejunum of SIV infected animals were examined for alterations in basal cytokine expression by RT-PCR. Remarkable changes in IFNgamma and IL-10 RNA levels were observed in IEL and LPL in SIV infection while IL-4 and
Down-modulation of the ZAP-70 protein tyrosine kinase in macaque T lymphocytes infected with SIVsmmPBj14.: J Med Primatol. 1998 Apr-Jun;27(2-3):141-7. Unique Identifier : AIDSLINE MED/98418751; Thai TH; Fultz PN; Department of Microbiology, University of Alabama School of; Medicine, Birmingham 35294, USA.; The simian immunodeficiency virus SIV-PBj14 is the most virulent primate lentivirus identified to date. Other SIV strains, including the parental SIVsmm9, require mitogen-activated peripheral blood mononuclear cells (PBMC) for replication in vitro; however, SIV-PBj14 replicates in quiescent pig-tailed macaque PBMC and
The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection.: J Med Primatol. 1998 Apr-Jun;27(2-3):50-8. Unique Identifier : AIDSLINE MED/98418739; Heeney JL; van Gils ME; van der Meide P; de Giuli Morghen C; Ghioni C; Gimelli M; Raddelli A; Davis D; Akerblom L; Morein B; Department of Virology, Biomedical Primate Research Center,; Rijswijk, The Netherlands. heeney@bprc.nl; The dichotomy of type-1 and type-2 T-helper (Th) immune responses is thought to be an obstacle to develop Human immunodeficiency virus-type- (HIV-1) vaccines capable of inducing effective cellular as well as humoral immune responses. Macaca mulatta were immunized using two different HIV-1sf2 envelope vaccine strategie
Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques.: J Med Primatol. 1998 Apr-Jun;27(2-3):59-64. Unique Identifier : AIDSLINE MED/98418740; Joag SV; Li Z; Wang C; Jia F; Foresman L; Adany I; Pinson DM; Stephens EB; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis and; Department of Microbiology, University of Kansas Medical Center,; Kansas City 66160-7424, USA.; By animal to animal passage in rhesus and pig-tailed macaques, we developed a rhesus model of HIV-1 disease in humans. Rhesus macaques infected with a cell-free stock of SHIVKU-2 developed CD4+ T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months po
Presence of circulating CTL induced by infection with wild-type or attenuated SIV and their correlation with protection from pathogenic SHIV challenge.: J Med Primatol. 1998 Apr-Jun;27(2-3):65-72. Unique Identifier : AIDSLINE MED/98418741; Vogel TU; Fournier J; Sherring A; Ko D; Parenteau M; Bogdanovic D; Mihowich J; Rud EW; National Laboratory for HIV Pathogenesis, Bureau of HIV/AIDS and; STD, LCDC, Ottawa, Ontario, Canada.; The aim of this study was to evaluate the role of CTLs in the protection from challenge with pathogenic SHIV in macaques vaccinated with attenuated virus. More specifically, we have analyzed the CTL response in cynomolgus macaques vaccinated/infected with the attenuated SIVmacC8 or the wild-type SIVmacJ5 and correlate
Sequence diversity of SIV(Mne) Nef in vivo and in vitro.: J Med Primatol. 1998 Apr-Jun;27(2-3):73-80. Unique Identifier : AIDSLINE MED/98418742; Heidecker G; Munoz H; Lloyd PA; Hodge DR; Pei GK; Rick SW; Brehm K; Ruscetti FW; Kuller L; Polacino P; Hu SL; Morton WR; Benveniste RE; SAIC/NCI-FCRDC, Frederick, Maryland 21702, USA.; heidecke@ncifcrf.gov; We have compared nef gene sequences isolated by PCR from peripheral blood lymphocyte DNA of macaques which had been inoculated with either biologically or molecularly cloned SIV(Mne). Two samples from each animal obtained either early after infection (week 2-8) or after significant CD4+ depletion (week 21-137) were an
In vitro infection of primate PBMC with simian/human immunodeficiency virus, SHIV(SF33A): correlation to in vivo outcome.: J Med Primatol. 1998 Apr-Jun;27(2-3):81-6. Unique Identifier : AIDSLINE MED/98418743; Harouse JM; Tan RC; Gettie A; Dailey P; Marx PA; Luciw PA; Cheng-Mayer C; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA.; The macaque/SIV animal system is an important model for studying AIDS pathogenesis and for evaluating the efficacy of vaccines and anti-viral therapeutics. However, differences between HIV-1 and SIV envelope proteins exist that render the SIV/macaque model of limited value when examining envelope determinants of retro
Natural history of SIVmac BK28 and H824 infection in Macaca nemestrina.: J Med Primatol. 1998 Apr-Jun;27(2-3):87-93. Unique Identifier : AIDSLINE MED/98418744; Mulvania T; Coon E; Kuller L; Agy MB; Morton WR; Mullins JI; Department of Microbiology, University of Washington, Seattle; 98195-7740, USA. mulvania@u.washington.edu; The natural histories of disease progression induced by two closely related molecular clones of SIVmac were evaluated to determine the utility of these viruses for modeling fast and slow progression to AIDS in Macaca nemestrina. Viral and immune parameters were measured to determine differential progression. Survival
SIVrcm infection of macaques.: J Med Primatol. 1998 Apr-Jun;27(2-3):94-8. Unique Identifier : AIDSLINE MED/98418745; Smith SM; Makuwa M; Lee F; Gettie A; Russo C; Marx PA; The Aaron Diamond AIDS Research Center, The Rockefeller; University, New York, New York 10016, USA. ssmith@adarc.org; In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red-Capped Mangabey (RCM) in Gabon . SIVrcm is divergent from HIV-1 and HIV-2/SIV families of primate lentiviruses. In this report, additional in vitro
In vitro HIV-1 infection in Macaca nemestrina PBMCs is blocked at a step beyond reverse transcription.: J Med Primatol. 1998 Apr-Jun;27(2-3):99-103. Unique Identifier : AIDSLINE MED/98418746; Kimball LE; Bosch ML; Department of Pathobiology, University of Washington, Seattle; 98195, USA.; Various stages in the lifecycle of HIV-1 were investigated in Macaca nemestrina and humans in vitro. Early events were analyzed by end point dilution DNA PCR with HIV-1 and SHIV infected PBMCs, while p24 and p27 ELISA assays were used to analyze core antigen production from infected cells. The results demonstrate that
Three-dimensional structure of H-2Dd complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120.: J Mol Biol. 1998;283(1):179-91. Unique Identifier : AIDSLINE MED/98437379; Li H; Natarajan K; Malchiodi EL; Margulies DH; Mariuzza RA; Center for Advanced Research in Biotechnology, University of; Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville,; MD, 20850, USA.; The crystal structure of the mouse major histocompatibility complex (MHC) class I molecule H-2Dd with an immunodominant peptide, designated P18-I10 (RGPGRAFVTI), from human immunodeficiency virus envelope glycoprotein 120 was determined at 3.2 A resolution. A novel orientation of the alpha3 domain of Dd relative to th
HIV-1 rev nuclear export signal binding peptides isolated by phage display.: J Mol Biol. 1998;283(1):245-54. Unique Identifier : AIDSLINE MED/98437384; Jensen A; Jensen TH; Kjems J; Department of Molecular and Structural Biology, University of; Aarhus, C.F. Mollers Alle, Aarhus C, DK-8000, Denmark.; The human immunodeficiency virus type 1 (HIV-1) Rev protein is absolutely essential in the viral replication cycle, where it induces the production of viral structural proteins. Rev functions in part by inducing the nuclear export of incompletely spliced mRNA species specified by the presence of an RNA element, the Re
Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).: J Mol Biol. 1998 Oct 23;283(2):419-34. Unique Identifier : AIDSLINE MED/98443244; Morellet N; Demene H; Teilleux V; Huynh-Dinh T; de Rocquigny H; Fournie-Zaluski MC; Roques BP; UFR des Sciences Pharmaceutiques et Biologiques, U 266 INSERM-URA; D1500 CNRS, 4 avenue de l'Observatoire, Paris Cedex 06, 75270,; France.; The nucleocapsid protein NCp7 of HIV-1 Mal contains two successive Zn knuckles of the CX2CX4HX4C type and plays a major role in virion morphogenesis, genomic RNA packaging and viral infectivity, mainly through single-stranded nucleic acid binding. We report here the study by 1H 2D NMR of the complex formed between the
The structural stability of the HIV-1 protease.: J Mol Biol. 1998 Oct 23;283(2):475-88. Unique Identifier : AIDSLINE MED/98443248; Todd MJ; Semo N; Freire E; Department of Biology and Biocalorimetry Center, The Johns; Hopkins University, Baltimore, MD, 21218, USA.; The most common strategy in the development of HIV-1 protease inhibitors has been the design of high affinity transition state analogs that effectively compete with natural substrates for the active site. A second approach has been the development of compounds that
The effectiveness of combined saquinavir and ketoconazole treatment in reducing HIV viral load.: J Natl Med Assoc. 1998 Oct;90(10):622-4. Unique Identifier : AIDSLINE MED/99020568; Jordan WC; Department of Internal Medicine and Family Practice, Charles R.; Drew University of Medicine and Science, King-Drew Medical; Center, Los Angeles, California 90059, USA.; With the advent of protease inhibitors , the treatment of persons infected with the human immunodeficiency virus (HIV) has resulted in lower levels of the virus in the blood. The first of these protease inhibitors was saquinavir, which inhibits the HIV protease enzym
Pneumocystis carinii infection of the small intestine.: J Natl Med Assoc. 1998 Oct;90(10):625-7. Unique Identifier : AIDSLINE MED/99020569; Kinchen K; Kinchen TH; Inglesby T Jr; Johns Hopkins Hospital, Baltimore, MD 21205, USA.; Extrapulmonary Pneumocystis carinii infections are rare in comparison to other opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS). In recent years, however, the number of reported cases of extrapulmonary pneumocystosis has increased. It is therefore important for physicians to recogniz
Partner notification and focused intervention as a means of identifying HIV-positive patients.: J Natl Med Assoc. 1998 Sep;90(9):542-6. Unique Identifier : AIDSLINE MED/98443893; Jordan WC; Tolbert L; Smith R; Department of Internal Medicine, Charles R. Drew University of; Medicine, Los Angeles, California, USA.; Partner notification as a means of contact tracing human immunodeficiency virus (HIV)-infected persons remains controversial. It is argued against by many gay activists, while primary public health officials and leaders in ethnic communities continue to support this as a means of identifying unknown cases. Human immun
The role of CD8+ cells and CD11a in the rejection-reaction of the allogeneic microskin grafting.: Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 1998 Aug;14(8):464-72. Unique Identifier : AIDSLINE MED/98453880; Lin SD; Chai CY; Tsai CC; Chou CK; Lin TM; Department of Surgery, Kaohsiung Medical College Hospital,; Taiwan, Republic of China.; By using histological tissue sections and immunohistochemical stains, the rejection-reaction of the allogeneic microskin grafting of rabbit-skin wounds was studied. The results revealed that the rejection started early in the days following transplantation. In the second week following transplantation, severe graft re
A third-generation lentivirus vector with a conditional packaging system.: J Virol. 1998 Nov;72(11):8463-71. Unique Identifier : AIDSLINE MED/98440501; Dull T; Zufferey R; Kelly M; Mandel RJ; Nguyen M; Trono D; Naldini L; Cell Genesys, Foster City, California 94404, USA.; Vectors derived from human immunodeficiency virus (HIV) are highly efficient vehicles for in vivo gene delivery. However, their biosafety is of major concern. Here we exploit the complexity of the HIV genome to provide lentivirus vectors with novel biosafety features. In addition to the structural genes, HIV contains
Molecular evidence for mother-to-child transmission of multiple variants by analysis of RNA and DNA sequences of human immunodeficiency virus type 1.: J Virol. 1998 Nov;72(11):8493-501. Unique Identifier : AIDSLINE MED/98440505; Pasquier C; Cayrou C; Blancher A; Tourne-Petheil C; Berrebi A; Tricoire J; Puel J; Izopet J; Laboratoire de Virologie, Centre Hospitalier Universitaire; Purpan, Toulouse, France. cpasquie@cict.fr; We have examined the viral selection that may occur during transmission by studying the env gene sequences from four cases of mother-to-child transmission of human immunodeficiency virus type 1. The V3 region sequences were directly amplified from both plasma viral RNA and peripheral blood mononuclear cells containing
Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.: J Virol. 1998 Nov;72(11):8627-35. Unique Identifier : AIDSLINE MED/98440521; Bogerd HP; Echarri A; Ross TM; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710, USA.; The hypothesis that the cellular protein Crm1 mediates human immunodeficiency virus type 1 (HIV-1) Rev-dependent nuclear export posits that Crm1 can directly interact both with the Rev nuclear export signal (NES) and with cellular nucleoporins. Here, we demonstrate that Crm1 is indeed able to interact with active but
Potential contributions of viral envelope and host genetic factors in a human immunodeficiency virus type 1-infected long-term survivor.: J Virol. 1998 Nov;72(11):8650-8. Unique Identifier : AIDSLINE MED/98440524; Grovit-Ferbas K; Ferbas J; Gudeman V; Sadeghi S; Goetz MB; Giorgi JV; Chen IS; O'Brien WA; Division of Hematology-Oncology, Department of Medicine, UCLA; School of Medicine and UCLA AIDS Institute, Los Angeles,; California 90095-1678, USA.; The lack of clinical progression in some individuals despite prolonged human immunodeficiency virus type 1 (HIV-1) infection may result from infection with less-pathogenic viral strains. To address this question, we examined the HIV-1 envelope protein from a donor with a low viral burden, stable CD4(+) T-lymphocyte co
Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein.: J Virol. 1998 Nov;72(11):8659-68. Unique Identifier : AIDSLINE MED/98440525; Heger P; Rosorius O; Koch C; Casari G; Grassmann R; Hauber J; Institute for Clinical and Molecular Virology, University; Erlangen-Nurnberg, D-91054 Erlangen, Germany.; The Rex trans-regulatory protein of human T-cell leukemia virus type 1 (HTLV-1) is required for the nuclear export of incompletely spliced and unspliced viral mRNAs and is therefore essential for virus replication. Rex is a nuclear phosphoprotein that directly binds to its cis-acting Rex response element RNA target se
Proteolytic processing and assembly of gag and gag-pol proteins of TED, a baculovirus-associated retrotransposon of the gypsy family.: J Virol. 1998 Nov;72(11):8718-24. Unique Identifier : AIDSLINE MED/98440533; Hajek KL; Friesen PD; Graduate Program in Cellular and Molecular Biology, Graduate; School and College of Agricultural and Life Sciences, University; of Wisconsin-Madison, Madison, Wisconsin 53706, USA.; TED (transposable element D) is an env-containing member of the gypsy family of retrotransposons that represents a possible retrovirus of invertebrates. This lepidopteran (moth) retroelement contains gag and pol genes that encode proteins capable of forming viruslike particles (VLP) with reverse transcriptase. Since V
CD4 promoter transactivation by human herpesvirus 6.: J Virol. 1998 Nov;72(11):8797-805. Unique Identifier : AIDSLINE MED/98440543; Flamand L; Romerio F; Reitz MS; Gallo RC; Laboratory of Virology, Rheumatology and Immunology Research; Center, Centre de Recherche du CHUL and Laval University,; Sainte-Foy, Quebec, Canada. louis.flamand@crchul.ulaval.ca; The observation that human herpesvirus 6 (HHV-6) can induce CD4 gene transcription and expression in CD4(-) cells was reported several years ago (P. Lusso, A. De Maria, M. Malnati, F. Lori, S. E. DeRocco, M. Baseler, and R. C. Gallo, Nature 349:533-535, 1991) and subsequently confirmed (P. Lusso, M. S. Malnati, A. Gar
Rhesus macaques infected with macrophage-tropic simian immunodeficiency virus (SIVmacR71/17E) exhibit extensive focal segmental and global glomerulosclerosis.: J Virol. 1998 Nov;72(11):8820-32. Unique Identifier : AIDSLINE MED/98440546; Stephens EB; Tian C; Li Z; Narayan O; Gattone VH 2nd; Marion Merrell Dow Laboratory of Viral Pathogenesis, Department; of Microbiology, Molecular Genetics and Immunology, University of; Kansas Medical Center, Kansas City, Kansas 66160, USA.; estephen@kumc.edu; We previously showed that inoculation of rhesus macaques with molecularly cloned lymphocytetropic simian immunodeficiency virus (SIVmac239) results in SIV-associated nephropathy (SIVAN) and that the glomerulosclerotic lesions were associated with the selection of macrophagetropic (M-tropic) variants (V. H. Gattone et
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.: J Virol. 1998 Nov;72(11):8833-40. Unique Identifier : AIDSLINE MED/98440547; Welker R; Harris M; Cardel B; Krausslich HG; Heinrich-Pette-Institut fur experimentelle Virologie und; Immunologie an der Universitat Hamburg, D-20251 Hamburg,; Germany.; The nef gene of primate immunodeficiency viruses is essential for high-titer virus replication and AIDS pathogenesis in vivo. In tissue culture, Nef is not required for human immunodeficiency virus (HIV) infection but enhances viral infectivity. We and others have shown that Nef is incorporated into HIV-1 particles an
Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey.: J Virol. 1998 Nov;72(11):8841-51. Unique Identifier : AIDSLINE MED/98440548; Novembre FJ; De Rosayro J; O'Neil SP; Anderson DC; Klumpp SA; McClure HM; Divisions of Microbiology and Immunology, Yerkes Regional Primate; Research Center, School of Medicine, Emory University, Atlanta,; Georgia 30322, USA. fnovembr@rmy.emory.edu; Transfusion of blood from a simian immunodeficiency virus (SIV)- and simian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to AIDS. To investigate the role of SIV in neurologic disease, virus was isolate
Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.: J Virol. 1998 Nov;72(11):8852-60. Unique Identifier : AIDSLINE MED/98440549; Mulloy JC; Kislyakova T; Cereseto A; Casareto L; LoMonico A; Fullen J; Lorenzi MV; Cara A; Nicot C; Giam C; Franchini G; Basic Research Laboratory, Division of Basic Sciences, National; Cancer Institute, Bethesda, Maryland 20892, USA.; jmulloy@helix.nih.gov; Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) transforms human T cells in vitro, and Tax, a potent transactivator of viral and cellular genes, plays a key role in cell immortalization. Tax activity is mediated by interaction with cellular transcription factors including members of the CREB/ATF family, the N
High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells.: J Virol. 1998 Nov;72(11):8873-83. Unique Identifier : AIDSLINE MED/98440551; Mochizuki H; Schwartz JP; Tanaka K; Brady RO; Reiser J; Molecular and Medical Genetics Section, Developmental and; Metabolic Neurology Branch, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Previously we designed novel pseudotyped high-titer replication defective human immunodeficiency virus type 1 (HIV-1) vectors to deliver genes into nondividing cells (J. Reiser, G. Harmison, S. Kluepfel-Stahl, R. O. Brady, S. Karlsson, and M. Schubert, Proc. Natl. Acad. Sci. USA 93:15266-15271, 1996). Since then we ha
Development of a neutralizing antibody response during acute primary human immunodeficiency virus type 1 infection and the emergence of antigenic variants.: J Virol. 1998 Nov;72(11):8943-51. Unique Identifier : AIDSLINE MED/98440558; Lewis J; Balfe P; Arnold C; Kaye S; Tedder RS; McKeating JA; School of Animal and Microbial Sciences, University of Reading,; Reading RG6 2AJ, United Kingdom.; We monitored the primary humoral response to human immunodeficiency virus type 1 infection and showed that, in addition to antibodies to p24 and gp41, antigens which form the basis of most diagnostic assays, the response included a significant antibody response directed to the gp120 region of the infecting viral quasi
Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains.: J Virol. 1998 Nov;72(11):8952-60. Unique Identifier : AIDSLINE MED/98440559; Huang L; Bosch I; Hofmann W; Sodroski J; Pardee AB; Divisions of Cancer Biology, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts 02115, USA.; lhuang@mbccrr.harvard.edu; Chemokine receptors CCR5 and CXCR4 are the primary fusion coreceptors utilized for CD4-mediated entry by macrophage (M)- and T-cell line (T)-tropic human immunodeficiency virus type 1 (HIV-1) strains, respectively. Here we demonstrate that HIV-1 Tat protein, a potent viral transactivator shown to be released as a solu
Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections.: J Virol. 1998 Nov;72(11):8976-87. Unique Identifier : AIDSLINE MED/98440562; Mwaengo DM; Novembre FJ; Division of Microbiology and Immunology, Yerkes Regional Primate; Research Center, Emory University, Atlanta, Georgia 30329, USA.; We have previously described the development of AIDS in a chimpanzee (C499) infected with human immunodeficiency virus type 1 (HIV-1) and the subsequent pathogenic HIV-1 infection in another chimpanzee (C455) transfused with blood from C499 (F. J. Novembre et al., J. Virol. 71:4086-4091, 1997). In the present study, t
Analysis of pol gene heterogeneity, viral quasispecies, and drug resistance in individuals infected with group O strains of human immunodeficiency virus type 1.: J Virol. 1998 Nov;72(11):9002-15. Unique Identifier : AIDSLINE +; Quinones-Mateu ME; Albright JL; Mas A; Soriano V; Arts EJ; Division of Infectious Diseases, Department of Medicine, Case; Western Reserve University, Cleveland, Ohio 44106, USA.; Nucleotide sequences of the reverse transcriptase (RT) coding region have been compared in four new human immunodeficiency virus type 1 (HIV-1) group O isolates. Phylogenetic analysis of this pol region highlights a cluster of these four HIV-1 group O sequences with seven other group O isolates (5% intracluster nucleo
The role of in vitro-induced lymphocyte apoptosis in feline immunodeficiency virus infection: correlation with different markers of disease progression.: J Virol. 1998 Nov;72(11):9025-33. Unique Identifier : AIDSLINE MED/98440566; Holznagel E; Hofmann-Lehmann R; Leutenegger CM; Allenspach K; Huettner S; Forster U; Niederer E; Joller H; Willett BJ; Hummel U; Rossi GL; Schupbach J; Lutz H; Clinical Laboratory, Department of Internal Veterinary Medicine,; University of Zurich, Zurich, Switzerland.; Human immunodeficiency virus infection is characterized by a progressive decline in the number of peripheral blood CD4(+) T lymphocytes, which finally leads to AIDS. This T-cell decline correlates with the degree of in vitro-induced lymphocyte apoptosis. However, such a correlation has not yet been described in feline
Importance of basic residues in the nucleocapsid sequence for retrovirus Gag assembly and complementation rescue.: J Virol. 1998 Nov;72(11):9034-44. Unique Identifier : AIDSLINE MED/98440567; Bowzard JB; Bennett RP; Krishna NK; Ernst SM; Rein A; Wills JW; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.; The Gag proteins of Rous sarcoma virus (RSV) and human immunodeficiency virus (HIV) contain small interaction (I) domains within their nucleocapsid (NC) sequences. These overlap the zinc finger motifs and function to provide the proper density to viral particles. There are two zinc fingers and at least two I domains w
Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients.: J Virol. 1998 Nov;72(11):9045-53. Unique Identifier : AIDSLINE MED/98440568; Power C; McArthur JC; Nath A; Wehrly K; Mayne M; Nishio J; Langelier T; Johnson RT; Chesebro B; Departments of Medical Microbiology, University of Manitoba,; Winnipeg, Manitoba R3E 0W3, Canada. power@ucalgary.ca; Human immunodeficiency virus type 1 (HIV-1) infection of the brain results in viral replication primarily in macrophages and microglia. Despite frequent detection of viral genome and proteins in the brains of AIDS patients with and without HIV dementia , only 20% of AIDS patients be
Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.: J Virol. 1998 Nov;72(11):9054-60. Unique Identifier : AIDSLINE MED/98440569; Kitchen SG; Korin YD; Roth MD; Landay A; Zack JA; Division of Hematology-Oncology, Department of Medicine, UCLA; School of Medicine, Los Angeles, California 90095, USA.; Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells re
A bipartite membrane-binding signal in the human immunodeficiency virus type 1 matrix protein is required for the proteolytic processing of Gag precursors in a cell type-dependent manner.: J Virol. 1998 Nov;72(11):9061-8. Unique Identifier : AIDSLINE MED/98440570; Lee YM; Tian CJ; Yu XF; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.; It is unclear whether proteolytic processing of the human immunodeficiency virus type 1 (HIV-1) Gag protein is dependent on virus assembly at the plasma membrane. Mutations that prevent myristylation of HIV-1 Gag proteins have been shown to block virus assembly and release from the plasma membrane of COS cells but do
Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS.: J Virol. 1998 Nov;72(11):9069-78. Unique Identifier : AIDSLINE MED/98440571; Joag SV; Liu ZQ; Stephens EB; Smith MS; Kumar A; Li Z; Wang C; Sheffer D; Jia F; Foresman L; Adany I; Lifson J; McClure HM; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis and; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City, Kansas 66160,; USA.; The chimeric simian-human immunodeficiency virus SHIVKU-1, bearing the envelope of human immunodeficiency virus type 1 (HIV-1), causes fulminant infection with subtotal loss of CD4(+) T cells followed by development of AIDS in intravaginally inoculated macaques and thus provides a highly relevant model of sexually tra
Studies of the neutralizing activity and avidity of anti-human immunodeficiency virus type 1 Env antibody elicited by DNA priming and protein boosting.: J Virol. 1998 Nov;72(11):9092-100. Unique Identifier : AIDSLINE MED/98440573; Richmond JF; Lu S; Santoro JC; Weng J; Hu SL; Montefiori DC; Robinson HL; Department of Pathology, University of Massachusetts School of; Medicine, Worcester, Massachusetts, USA.; DNA vaccination is an effective means of eliciting strong antibody responses to a number of viral antigens. However, DNA immunization alone has not generated persistent, high-titer antibody and neutralizing antibody responses to human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env). We have previousl
Neurovirulence in feline immunodeficiency virus-infected neonatal cats is viral strain specific and dependent on systemic immune suppression.: J Virol. 1998 Nov;72(11):9109-15. Unique Identifier : AIDSLINE MED/98440575; Power C; Buist R; Johnston JB; Del Bigio MR; Ni W; Dawood MR; Peeling J; Department of Clinical Neurosciences, University of Calgary,; Calgary, Alberta T2N 4N1 Canada. power@ucalgary.ca; Feline immunodeficiency virus (FIV) is a lentivirus that causes immune suppression and neurological disease in cats. Among animal viruses, individual viral strains have been shown to be neurovirulent, but the role of viral strain specificity among lentiviruses and its relationship to systemic immune suppression in the
Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice.: J Virol. 1998 Nov;72(11):9208-16. Unique Identifier : AIDSLINE MED/98440587; Homann D; Tishon A; Berger DP; Weigle WO; von Herrath MG; Oldstone MB; Division of Virology, Department of Neuropharmacology, The; Scripps Research Institute, La Jolla, California 92037, USA.; Adoptive transfer of virus-specific memory lymphocytes can be used to identify factors and mechanisms involved in the clearance of persistent virus infections. To analyze the role of B cells in clearing persistent infection with lymphocytic choriomeningitis virus (LCMV), we used B-cell-deficient muMT/muMT (B-/-) mice.
The 5' and 3' TAR elements of human immunodeficiency virus exert effects at several points in the virus life cycle.: J Virol. 1998 Nov;72(11):9217-23. Unique Identifier : AIDSLINE MED/98440588; Das AT; Klaver B; Berkhout B; Department of Human Retrovirology, University of Amsterdam,; Academic Medical Center, Amsterdam, The Netherlands.; The human immunodeficiency virus type 1 RNA genome contains a terminal repeat (R) sequence that encodes the TAR hairpin motif, which has been implicated in Tat-mediated activation of transcription. More recently, a variety of other functions have been proposed for this structured RNA element. To determine the replicat
Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1.: J Virol. 1998 Nov;72(11):9307-12. Unique Identifier : AIDSLINE MED/98440599; Zhang L; He T; Huang Y; Chen Z; Guo Y; Wu S; Kunstman KJ; Brown RC; Phair JP; Neumann AU; Ho DD; Wolinsky SM; The Aaron Diamond AIDS Research Center, The Rockefeller; University, New York, New York 10016, USA. izhang@adarc.org; We tested chemokine receptor subset usage by diverse, well-characterized primary viruses isolated from peripheral blood by monitoring viral replication with CCR1, CCR2b, CCR3, CCR5, and CXCR4 U87MG.CD4 transformed cell lines and STRL33/BONZO/TYMSTR and GPR15/BOB HOS.CD4 transformed cell lines. Primary viruses were iso
The C-terminal half of the human immunodeficiency virus type 1 Gag precursor is sufficient for efficient particle assembly.: J Virol. 1998 Nov;72(11):9313-7. Unique Identifier : AIDSLINE MED/98440600; Borsetti A; Ohagen A; Gottlinger HG; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, and Department of Pathology, Harvard Medical School,; Boston, Massachusetts 02215, USA.; Human immunodeficiency virus type 1 particle assembly is directed by the Gag polyprotein Pr55(gag), the precursor for the matrix (MA), capsid (CA), and nucleocapsid proteins of the mature virion. We now show that CA sequences N terminal to the major homology region (MHR), which form a distinct domain, are dispensable
Level of ICAM-1 surface expression on virus producer cells influences both the amount of virion-bound host ICAM-1 and human immunodeficiency virus type 1 infectivity.: J Virol. 1998 Nov;72(11):9329-36. Unique Identifier : AIDSLINE MED/98440603; Paquette JS; Fortin JF; Blanchard L; Tremblay MJ; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire de Quebec, Pavillon CHUL, and Departement de; Biologie Medicale, Faculte de Medecine, Universite Laval,; Ste-Foy, Quebec, Canada G1V 4G2.; Using virions harvested from 293T cells stably expressing either low or high levels of surface ICAM-1, we determined that the number of virus-embedded host ICAM-1 proteins is positively influenced by the expression level of ICAM-1 on virus producer cells. Moreover, the increase in virion-bound host cell membrane ICAM-
Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.: J Virol. 1998 Nov;72(11):9337-44. Unique Identifier : AIDSLINE MED/98440604; Zhang YJ; Dragic T; Cao Y; Kostrikis L; Kwon DS; Littman DR; KewalRamani VN; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York University School of Medicine, New York, New York 10016,; USA.; We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could uti
CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.: J Virol. 1998 Nov;72(11):9345-7. Unique Identifier : AIDSLINE MED/98440605; Sylwester AW; Grivel JC; Fitzgerald W; Rossio JL; Lifson JD; Margolis LB; Laboratory of Cellular and Molecular Biophysics, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892-1855, USA.; We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions
Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNA.: J Virol. 1998 Nov;72(11):9353-8. Unique Identifier : AIDSLINE MED/98440607; Rong L; Liang C; Hsu M; Kleiman L; Petitjean P; de Rocquigny H; Roques BP; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, Montreal, Quebec, Canada H3T 1E2.; To study the initiation of human immunodeficiency virus type 1 reverse transcription, we have used the viral nucleocapsid protein (NC7) to anneal tRNA3Lys primer onto viral genomic RNA and have then eliminated NC7 from this primer-template complex by digestion with proteinase K and phenol-chloroform extraction of resi
Mapping of epitopes exposed on intact human immunodeficiency virus type 1 (HIV-1) virions: a new strategy for studying the immunologic relatedness of HIV-1.: J Virol. 1998 Nov;72(11):9384-91. Unique Identifier : AIDSLINE MED/98440613; Nyambi PN; Gorny MK; Bastiani L; van der Groen G; Williams C; Zolla-Pazner S; Department of Pathology, New York University Medical Center, New; York, New York 10016, USA.; To study the antigenic conservation of epitopes of human immunodeficiency virus type 1 (HIV-1) isolates of different clades, the abilities of human anti-HIV-1 gp120 and gp41 monoclonal antibodies (MAbs) to bind to intact HIV-1 virions were determined by a newly developed virus-binding assay. Eighteen human anti-HIV MA
The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein.: J Virol. 1998 Nov;72(11):9396-9. Unique Identifier : AIDSLINE MED/98440615; Colgin MA; Nyborg JK; Department of Biochemistry and Molecular Biology, Colorado State; University, Fort Collins, Colorado 80523-1870, USA.; Tax, the transforming protein of human T-cell leukemia virus type 1 (HTLV-1), is required for strong activation of HTLV-1 transcription. This activation is mediated through interaction with the KIX domain of the cellular coactivator CREB binding protein (CBP). In this study we examined the possibility that the Tax-KIX
US AIDS research office chief: intensify vaccine, prevention research [news]: JAMA. 1998 Oct 14;280(14):1211-3. Unique Identifier : AIDSLINE MED/99000325; Stephenson J
Multistate evaluation of anonymous HIV testing and access to medical care. Multistate Evaluation of Surveillance of HIV (MESH) Study Group.: JAMA. 1998 Oct 28;280(16):1416-20. Unique Identifier : AIDSLINE MED/99015620; Bindman AB; Osmond D; Hecht FM; Lehman JS; Vranizan K; Keane D; Reingold A; Primary Care Research Center, San Francisco General Hospital, and; Department of Medicine, University of California, 94110, USA.; bindman@itsa.ucsf.edu; CONTEXT: Infection with the human immunodeficiency virus (HIV) is the only infectious disease for which anonymous testing is publicly funded, an exception that has been controversial. OBJECTIVE: To assess whether anonymous HIV testing was associated with earlier HIV testing and HIV-related medical care than confidenti
Effect of HIV reporting by name on use of HIV testing in publicly funded counseling and testing programs.: JAMA. 1998 Oct 28;280(16):1421-6. Unique Identifier : AIDSLINE MED/99015621; Nakashima AK; Horsley R; Frey RL; Sweeney PA; Weber JT; Fleming PL; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA. a1n1@cdc.gov; CONTEXT: Policies requiring confidential reporting by name to state health departments of persons infected with the human immunodeficiency virus (HIV) have potential to cause some of them to avoid HIV testing. OBJECTIVE: To describe trends in use of HIV testing services at publicly funded HIV counseling and testing si
From the Food and Drug Administration.: JAMA. 1998 Nov 4;280(17):1472. Unique Identifier : AIDSLINE MED/99025588; Nightingale SL
Sex at risk: politically or factually correct? [letter]: JAMA. 1998 Nov 4;280(17):1482. Unique Identifier : AIDSLINE MED/99025596; Brody S
Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators.: JAMA. 1998 Nov 4;280(17):1497-503. Unique Identifier : AIDSLINE MED/99025602; Detels R; Munoz A; McFarlane G; Kingsley LA; Margolick JB; Giorgi J; Schrager LK; Phair JP; School of Public Health, University of California, Los Angeles; 90095-1772, USA. detels@ucla.edu; CONTEXT: Time to development of acquired immunodeficiency syndrome (AIDS) and time to death have been extended with the increased use of combination therapy and protease inhibitors . Cohort studies following up person
Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.: JAMA. 1998 Nov 11;280(18):1590-5. Unique Identifier : AIDSLINE MED/99036147; Shlay JC; Chaloner K; Max MB; Flaws B; Reichelderfer P; Wentworth D; Hillman S; Brizz B; Cohn DL; Denver Community Programs for Clinical Research on AIDS, Colo,; USA. jshlay@dhha.org; CONTEXT: Peripheral neuropathy is common in persons infected with the human immunodeficiency virus (HIV) but few data on symptomatic treatment are available. OBJECTIVE: To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related
The reliability of muscle function analysis using different methods of stimulation.: JPEN J Parenter Enteral Nutr. 1998 Sep-Oct;22(5):331-4. Unique Identifier : AIDSLINE MED/98409419; Brooks SD; Gerstman, BB; Sucher KP; Kearns PJ; California Institute for Medical Research and Department of; Medicine, Santa Clara Valley Medical Center, San Jose 95128, USA.; BACKGROUND: The purpose of our study was to determine the reliability of nonvolitional muscle function analysis (MFA) by determining the day-to-day and within-day reliability of conventional electrical stimulation and a newer, magneto-electrical stimulation method, using standard laboratory methodology. METHODS: Ten h
Prevalence of hepatitis B, C and HIV virus infection among beta thalassaemia major patients [letter]: JPMA J Pak Med Assoc. 1998 Mar;48(3):87. Unique Identifier : AIDSLINE MED/98456367; Shamsi T; Ahmed A; Taj Z; Vajid MA; Hassan F
[Molecular medicine of chemokine receptors]: Nippon Rinsho. 1998 Jul;56(7):1807-12. Unique Identifier : AIDSLINE MED/98367379; Hirai K; Department of Bioregulatory Function, University of Tokyo School; of Medicine.; Chemokines belong to a family of small secreted proteins that play essential roles in the recruitment and activation of leukocytes at the sites of inflammation. Thirteen chemokine receptors have already been cloned and shown to be organized with a structure of seven-transmembrane-domain receptors, a structure typical
Advanced testicular germ cell tumor in a hemophilic patient with human immunodeficiency virus infection.: Jpn J Clin Oncol. 1998 Sep;28(9):567-70. Unique Identifier : AIDSLINE MED/99009427; Kageyama Y; Kihara K; Tosaka A; Nagai H; Ishizaka K; Tsujii T; Oshima H; Department of Urology, Tokyo Medical and Dental University School; of Medicine, Japan. kageyys.uro@med.tmd.ac.jp; A stage IIIB anaplastic seminoma which occurred in an HIV-infected hemophilia is reported. The patient with hemophilia A was 36 years old and had been seropositive for HIV antibody for 3 years. Inguinal orchiectomy and subsequent chemoradiotherapy for retroperitoneal lymphadenopathy were performed and a marker negativ
[A case of AIDS with pleuropulmonary tuberculosis in which PCR was useful in making definitive diagnosis]: Kekkaku. 1998 Jul;73(7):491-5. Unique Identifier : AIDSLINE MED/98411899; Ohtomo K; Sugawara I; Masunaga A; Research Institute of Tuberculosis, Japan Anti-Tuberculosis; Association, Tokyo, Japan.
A replication study of Reducing the Risk, a theory-based sexuality curriculum for adolescents.: J Sch Health. 1998 Aug;68(6):243-7. Unique Identifier : AIDSLINE MED/98386467; Hubbard BM; Giese ML; Rainey J; Dept. of Health Sciences, University of Central Arkansas, Conway; 72035, USA.; Reducing the Risk is a theory-based, sexuality education curriculum shown to influence the knowledge and behaviors of secondary students. This study determined whether the behavioral effects of the curriculum could be duplicated in a southern, rural state. In a quasiexperimental design, pretest and posttest inventorie
Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs.: J Surg Res. 1998 Oct;79(2):115-20. Unique Identifier : AIDSLINE MED/98432969; Tyler DS; Stanley SD; Bartlett JA; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Lymphocytes from HIV-1-seropositive and -seronegative individuals were examined to determine whether HIV-1 infection interfered with the ability to generate a lymphokine-activated killer (LAK) cell response. Following a 3-day ex vivo incubation in the presence of 1000 U/ml of recombinant interleukin-2, lymphocytes fro
The dynamics of drug action on the within-host population growth of infectious agents: melding pharmacokinetics with pathogen population dynamics.: J Theor Biol. 1998 Oct 7;194(3):313-39. Unique Identifier : AIDSLINE MED/98453587; Austin DJ; White NJ; Anderson RM; Wellcome Trust Centre for the Epidemiology of Infectious; Diseases, University of Oxford, South Parks Road, Oxford, OX1; 3PS, U.K. daren.austin@zoology.ox.ac.uk; The use of simple mathematical models to study the kinetics of drug action and decay within vertebrate hosts has a long history with a major objective being to derive drug dosage regimens that optimize efficacy and minimize toxicity to the patient. Mathematical models of the relationship between dosage, route of deliv
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).: Leukemia. 1998 Oct;12(10):1507-17. Unique Identifier : AIDSLINE MED/98437882; Drexler HG; Uphoff CC; Gaidano G; Carbone A; DSMZ-German Collection of Microorganisms and Cell Cultures,; Department of Human and Animal Cell Cultures, Braunschweig.; Primary effusion lymphoma (PEL; also known as body cavity-based lymphoma) is recognized as a new and unique lymphoma entity occurring predominantly, but not exclusively in human immunodeficiency virus (HIV)-seropositive patients with acquired immunodeficiency syndrome (AIDS). PEL grows exclusively in body cavities as
CD57+/CD28- T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis.: Leukemia. 1998 Oct;12(10):1573-82. Unique Identifier : AIDSLINE MED/98437892; Van den Hove LE; Van Gool SW; Vandenberghe P; Boogaerts MA; Ceuppens JL; Laboratory of Experimental Immunology, Faculty of Medicine,; Catholic University of Leuven, Belgium.; Three-color flow cytometry immunophenotyping revealed significant increases of CD57+ and CD28- cells among both circulating CD4+ and CD8+ T lymphocytes of untreated hemato-oncological patients (n = 54) as compared to healthy donors (n = 55), with CD57 and CD28 expression on the patients T cells being largely reciproc
A novel single cell PCR assay: detection of human T lymphotropic virus type I DNA in lymphocytes of patients with adult T cell leukemia.: Leukemia. 1998 Oct;12(10):1645-50. Unique Identifier : AIDSLINE MED/98437902; Miyagi T; Murakami K; Sawada T; Taguchi H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; The abnormal lymphocytes in adult T cell leukemia (ATL) reveal a peculiar morphology that is characterized by indented or lobulated nuclei. While human T lymphotropic virus type I (HTLV-I) is thought to be integrated in ATL cells, the correlation between the nuclear irregularities and HTLV-I infection is obscure. We h
Conventional and genetic laboratory tests used to guide antimicrobial therapy.: Mayo Clin Proc. 1998 Oct;73(10):1007-21. Unique Identifier : AIDSLINE MED/99004021; Cockerill FR 3rd; Division of Clinical Microbiology, Mayo Clinic Rochester,; Minnesota 55905, USA.; Detection of antimicrobial resistance is important so that clinicians can make rational decisions about optimal antimicrobial therapy for their patients. During the past decade, new types of antimicrobial resistance have emerged, some of which present new challenges for the clinical microbiology laboratory. In most ca
Age-related loss of immunoregulatory function in peripheral blood CD8 T cells.: Mech Ageing Dev. 1998 Jul 15;103(3):235-54. Unique Identifier : AIDSLINE MED/98389294; Crisi GM; Chen LZ; Huang C; Thorbecke GJ; Department of Pathology and Kaplan Comprehensive Cancer Center,; New York University School of Medicine, NY 10016, USA.; CD8+ T cells from young individuals become inhibitory for the (Staphylococcus aureus + interleukin 2)-induced differentiation of autologous B cells into immunoglobulin secreting cells (ISC) after exposure to pokeweed mitogen (PWM), dimaprit or intracellular cAMP raising agents, such as forskolin or dibutyryl-cAMP. In
Determinants of home health visit length: results of a multisite prospective study.: Med Care. 1998 Oct;36(10):1500-14. Unique Identifier : AIDSLINE MED/99008474; Payne SM; Thomas CP; Fitzpatrick T; Abdel-Rahman M; Kayne HL; Case Western Reserve University, Cleveland, OH 44109-1998, USA.; OBJECTIVES: The authors (1) compare visit length across four categories of skilled nursing home health visits which reflect recent changes in home health casemix-AIDS-related, hospice/terminal (HT), intravenous (IV) therapy, and maternal and child health (MCH)-with general adult medical/surgical (MS) visits and (2) id
[Detection of bacteremia in patients discharged from an emergency unit: study of 61 cases]: Med Clin (Barc). 1998 Sep 5;111(6):201-4. Unique Identifier : AIDSLINE MED/99005653; Tudela P; Queralt C; Gimenez M; Carreres A; Tor J; Sopena N; Valencia J; Unidad de Urgencias, Servicio de Microbiologia, Badalona,; Barcelona.; BACKGROUND: To know the prevalence, the clinical and microbiological characteristics of bacteremia episodes detected on discharged patients at the emergency unit, as well as the accordance of diagnostics and the predicting factors. PATIENTS AND METHODS: We analysed the cases with bacteria detected on discharged patien
[Evolution of the prevalence of HIV-1 infection in drug addicts in the Community of Madrid (1985-1986)]: Med Clin (Barc). 1998 Sep 12;111(7):257-8. Unique Identifier : AIDSLINE MED/99005669; Sopelana P; Carrascosa C; Garcia-Benito P; Servicio Regional de Salud, Hospital Psiquiatrico de Madrid.; BACKGROUND: To evaluate the evolution of the HIV infection in the drug addicts of Madrid. PATIENTS AND METHODS: Data of 2,234 patients that entered for the first time in a Psychiatric Hospital Detoxication Unit of Madrid from October 1985 to december 1996 were recorded. RESULTS: There was a reduction of the percentage
[HIV infection in mental disease: a new group with risk behaviors (editorial)]: Med Clin (Barc). 1998 Sep 19;111(8):292-3. Unique Identifier : AIDSLINE MED/99028242; Ayuso Mateos JL
[Ochrobactrum anthropi bacteremia in a patient with AIDS (letter)]: Med Clin (Barc). 1998 Sep 19;111(8):318. Unique Identifier : AIDSLINE MED/99028249; Torres L; Arazo P; Seoane A; Marco ML
[Treatment of HIV infections--an update. The easy work is done--the difficult is still to be done]: Lakartidningen. 1998 Oct 14;95(42):4562-4. Unique Identifier : AIDSLINE MED/99031550; Sonnerborg A; Pehrsson P; Infektionskliniken, Huddinge sjukhus.
[Lipodystrophy--an adverse effect of protease inhibitors used against HIV infection? Concern about negative delayed effects of this break-through]: Lakartidningen. 1998 Oct 14;95(42):4616-7. Unique Identifier : AIDSLINE MED/99031559; Morfeldt L; Jonsson B; Regnstrom J; Infektionskliniken, Danderyd/Karolinska sjukhuset, Stockholm.
Surrogacy in HIV-1 clinical trials [comment]: Lancet. 1998 Feb 21;351(9102):536-7. Unique Identifier : AIDSLINE MED/99027377; Pozniak A; Department of HIV and Genitourinary Medicine, King's College; Hospital, London, UK.
Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. Advanced HIV Disease Ritonavir Study Group [see comments]: Lancet. 1998 Feb 21;351(9102):543-9. Unique Identifier : AIDSLINE MED/99027382; Cameron DW; Heath-Chiozzi M; Danner S; Cohen C; Kravcik S; Maurath C; Sun E; Henry D; Rode R; Potthoff A; Leonard J; Department of Medicine, University of Ottawa, Ottawa General; Hospital, Ontario, Canada.; BACKGROUND: Ritonavir is a potent, orally bioavailable inhibitor of HIV-1 protease. We undertook an international, multicentre, randomised, double-blind, placebo-controlled trial of ritonavir in patients with HIV-1 infection and CD4-lymphocyte counts
Nevirapine-associated Stevens-Johnson syndrome [letter]: Lancet. 1998 Feb 21;351(9102):567. Unique Identifier : AIDSLINE MED/99027388; Warren KJ; Boxwell DE; Kim NY; Drolet BA
Syphilis in prostitutes from Eastern Europe [letter]: Lancet. 1998 Feb 21;351(9102):572. Unique Identifier : AIDSLINE MED/99027395; Smacchia C; Parolin A; Di Perri G; Vento S; Concia E
Public warned about HIV-1-positive prostitute in Italy [news]: Lancet. 1998 Feb 21;351(9102):580. Unique Identifier : AIDSLINE MED/99027399; Simini B
Perinatal HIV-1 transmission discussed in Geneva [news; comment]: Lancet. 1998 Jul 4;352(9121):39. Unique Identifier : AIDSLINE MED/99015354; Bradbury J; McCarthy M
US Court rules HIV infection confers disability [news]: Lancet. 1998 Jul 4;352(9121):45. Unique Identifier : AIDSLINE MED/99015357; McCarthy M
Disease surveillance at district level: a model for developing countries.: Lancet. 1998 Jul 4;352(9121):58-61. Unique Identifier : AIDSLINE MED/99015366; John TJ; Samuel R; Balraj V; John R; Department of Clinical Virology, Christian Medical College; Hospital, Vellore, Tamil Nadu, India.; For over a decade we have maintained within a district of 5 million people, a system of prompt reporting of cases of childhood vaccine-preventable diseases, encephalitis, meningitis, hepatitis, and rabies; together with a sentinel laboratory surveillance of cholera, typhoid fever, malaria, HIV infection and antimicrob
African traditional medicine--potential route for viral transmission? [letter]: Lancet. 1998 Jul 4;352(9121):71. Unique Identifier : AIDSLINE MED/99015382; Jolles S; Jolles F
Men in India respond to HIV-1 education [news]: Lancet. 1998 Oct 3;352(9134):1124. Unique Identifier : AIDSLINE MED/99012944; Wunsch H
US Senate moves to broaden HIV-1 payment [news]: Lancet. 1998 Oct 3;352(9134):1128. Unique Identifier : AIDSLINE MED/99012948; Droste TM
Amsterdam Duration of Antiretroviral Medication (ADAM) study [letter]: Lancet. 1998 Oct 3;352(9134):1149. Unique Identifier : AIDSLINE MED/99012963; Torres RA; Bellman PC; Barr M
Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease. Immunology Study Group of Spanish EARTH-1 Study [letter]: Lancet. 1998 Oct 10;352(9135):1194-5. Unique Identifier : AIDSLINE MED/98449272; Plana M; Garcia F; Gallart T; Miro JM; Gatell JM
Voluntary blood tests for Canadian doctors? [news]: Lancet. 1998 Oct 10;352(9135):1205. Unique Identifier : AIDSLINE MED/98449282; Kondro W
Antiretroviral treatment [letter]: Lancet. 1998 Oct 10;352(9135):1224-5. Unique Identifier : AIDSLINE MED/98449296; Boelaert JR; Sperber K
British HIV Association guidelines [letter]: Lancet. 1998 Oct 10;352(9135):1226. Unique Identifier : AIDSLINE MED/98449298; Hay P; Mitchla Z
British HIV Association guidelines [letter]: Lancet. 1998 Oct 10;352(9135):1226-7. Unique Identifier : AIDSLINE MED/98449299; Montaner JS; Raboud J; Rae S; Vella S
Zidovudine and confusion in urinary metabolic screening [letter]: Lancet. 1998 Oct 10;352(9135):1227. Unique Identifier : AIDSLINE MED/98449301; Sewell AC
Concern voiced over "dry sex" practices in South Africa [news]: Lancet. 1998 Oct 17;352(9136):1292. Unique Identifier : AIDSLINE MED/99002522; Baleta A
IOM recommends routine HIV tests in pregnancy [news]: Lancet. 1998 Oct 17;352(9136):1294. Unique Identifier : AIDSLINE MED/99002523; Droste TM
An HIV vaccine: how long must we wait? [editorial]: Lancet. 1998 Oct 24;352(9137):1323. Unique Identifier : AIDSLINE MED/99017247
Different HIV-1 strains found in semen and blood [news]: Lancet. 1998 Oct 24;352(9137):1363. Unique Identifier : AIDSLINE MED/99017271; Birchard K
Access to treatment for HIV in developing countries; statement from international seminar on access to treatment for HIV in developing countries, London, June 5 and 6, 1998. UK NGO AIDS Consortium Working Group on Access to Treatment for HIV in Developing Countries.: Lancet. 1998 Oct 24;352(9137):1379-80. Unique Identifier : AIDSLINE MED/99017276; Compared with those in industrialised countries, people in developing countries have little access to treatment for HIV infection, or for many other diseases including cancer, tuberculosis, and malaria. Although attention has been paid to areas such as provision of essential drugs, strengthening of infrastructures and
Fat accumulation and HIV-1 protease inhibitors [letter]: Lancet. 1998 Oct 24;352(9137):1392. Unique Identifier : AIDSLINE MED/99017293; Stricker RB; Goldberg B
In-vivo anti-CD3-induced HIV-1 viraemia [letter]: Lancet. 1998 Oct 31;352(9138):1446. Unique Identifier : AIDSLINE MED/99023155; Brinkman K; Huysmans F; Galama JM; Boucher CA
[Cytomegalovirus retinitis in patients with human immunodeficiency virus infection]: Lijec Vjesn. 1998 May;120(5):106-10. Unique Identifier : AIDSLINE MED/98420610; Mesaric B; Begovac J; Ugrinovic N; Babic K; Lisic M; Klinika za infektivne bolesti Dr. Fran Mihaljevic, Zagreb.; Cytomegalovirus retinitis (CMVR) is a common opportunistic infection and a major cause of blindness in patients with AIDS. The aim of this study was to determine the frequency, clinical course and outcome of CMVR in patients treated at the University Hospital of Infectious Diseases Dr. Fran Mihaljevic in Zagreb in t
Anticonvulsant phenytoinergic pharmacophores and anti-HIV activity--preliminary evidence for the dual requirement of the 4-aminophthalimide platform and the N-(1-adamantyl) substitution for antiviral properties.: Life Sci. 1998;63(19):PL267-74. Unique Identifier : AIDSLINE MED/99021066; Vamecq J; Van derpoorten K; Poupaert JH; Balzarini J; De Clercq E; Stables JP; INSERM-CHRU de Lille, Domaine du CERTIA, Villeneuve d'Ascq,; France.; This work is aimed at further exploring the concept that phenytoin-related compounds might present with an anti-HIV potential. We screened for anti-HIV activity, selected compounds whose structural design rests on pharmacophores successfully shown to convey phenytoinergic anticonvulsant activity. We determined the cor
HIV/AIDS and human rights in prison. The Costa Rican experience.: Med Law. 1998;17(2):197-210. Unique Identifier : AIDSLINE MED/98430299; Valerio Monge CJ; HIV and AIDS issues deal directly with Human Rights and Public Health. Four basic principles have been acknowledged internationally in connection with HIV/AIDS: Autonomy, confidentiality, right to health and non-discrimination. According to these principles, it is not possible to adopt illegal or unethical measures to
Expanding the newborn screen: terrific or troubling?: MCN Am J Matern Child Nurs. 1998 Sep-Oct;23(5):266-71. Unique Identifier : AIDSLINE MED/98419227; Kunk RM; NICU, Winchester Medical Center in Winchester, Virginia, USA.; rkunk@shentel.net; Amid controversy about cost-benefit ratios and ethical issues of discrimination and presumed consent, individual U.S. states are on the verge of expanding the newborn screen. The success of population-based newborn screening for genetic and metabolic disorders has been called the miracle of our times. Rapid scientific
[Cytomegalovirus polyradiculomyelopathy in AIDS]: Medicina (B Aires). 1998;58(2):135-40. Unique Identifier : AIDSLINE MED/98371519; Jayaweera DT; Cassetti LI; Espinoza L; Lopardo GD; Hansman-Whiteman ML; Scerpella EG; Department of Medicine, University of Miami School of Medicine,; Florida, USA.; To evaluate the efficacy of ganciclovir, foscarnet, or the combination of both for the treatment of cytomegalovirus polyradiculomyelopathy (CMV-PRAM), we reviewed the records of seven patients with AIDS, diagnosed with CMV-PRAM. Muscle strength was graded according to the Medical R
[Resistance and multiresistance to antitubercular drugs in Argentina and in other Latin American countries]: Medicina (B Aires). 1998;58(2):202-8. Unique Identifier : AIDSLINE MED/98371531; de Kantor IN; Latini O; Barrera L; Organizacion Panamericana de la Salud (OPS/OMS), Buenos Aires,; Argentina. ikantorp@overnet.com.ar; Resistance of Mycobacterium tuberculosis to both isoniazid (INH) and rifampicin (RPM), the most important antituberculosis drugs, with or without simultaneous resistance to other drugs, is known as multidrug resistance (MDR). It is the main obstacle to attain the cure of patients by the specific treatment, and a threa
[Dendritic cells and their role in pathology]: Medicina (B Aires). 1998;58(2):209-18. Unique Identifier : AIDSLINE MED/98371532; Coronato S; Laguens GE; Spinelli OM; Salas MA; Di Girolamo W; Catedra de Patologia B, Facultad de Ciencias Medicas,; Universidad Nacional de La Plata, Argentina.; The aim of this review is to update the knowledge on dendritic cells (CD), as potent antigen-presenting cells (APC) expressing class II major histocompatibility (MHC) antigen. The different types of DC are derived from a common bone marrow precursor. They differentiate and migrate to lymphoid and non-lymphoid tissues
Structure-based prediction of binding affinities and molecular design of peptide ligands.: Methods Enzymol. 1998;295:100-27. Unique Identifier : AIDSLINE MED/98422610; Luque I; Freire E; Department of Biology, Johns Hopkins University, Baltimore,; Maryland 21218, USA.
Breaking the nexus between asthma and atopy [editorial]: Med J Aust. 1998 Oct 5;169(7):354-5. Unique Identifier : AIDSLINE MED/99020086; Holt PG; Sly PD
Thalidomide.: Med Lett Drugs Ther. 1998 Oct 23;40(1038):103-4. Unique Identifier : AIDSLINE MED/99031140
Role of curdlan sulfate in the production of beta-chemokines and interleukin-16.: Med Microbiol Immunol (Berl). 1998 Jun;187(1):43-8. Unique Identifier : AIDSLINE MED/98420429; Naito T; Takeda-Hirokawa N; Kaneko H; Sekigawa I; Matsumoto T; Hashimoto H; Kaneko Y; Department of General Medicine, Juntendo University School of; Medicine, Tokyo, Japan.; The blocking effect of curdlan sulfate (CRDS) on human immunodeficiency virus (HIV) infection has been thought to be related to inhibition of the binding of HIV-1 envelope glycoprotein (gp120) and CD4 molecules. However, recent reports have indicated that blocking the binding of gp120 to CD4 by CRDS only makes a small
[Candida albicans morphotypes and in vitro adhesivity to cells of the human oral mucosa in HIV-positive and AIDS patients after exposure of blastospores to fluconazole. II]: Minerva Stomatol. 1998 Jul-Aug;47(7-8):293-7. Unique Identifier : AIDSLINE MED/99009757; Spadari E; Arosio M; Malighetti V; Bellotti MG; Artini MZ; Spadari F; Riviera L; Istituto di Microbiologia Medica, Universita degli Studi,; Milano.; BACKGROUND: Oro-pharyngeal candidosis is a frequently initial clinical manifestation of HIV infection and the adhesive properties of Candida spp. represent a very important pathogenicity factor. METHODS: In this study the adhesivity rate of Candida albicans to the oral epithelial cells of 33 HIV-positive patients and
Prevention and treatment of tuberculosis among patients infected with human immunodeficiency virus: principles of therapy and revised recommendations. Centers for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1998 Oct 30;47(RR-20):1-58. Unique Identifier : AIDSLINE MED/99025615; These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States . The most notable changes in these guidelines reflect both the findin
[Host reactions affect cancer progression]: Nippon Geka Gakkai Zasshi. 1998 Jul;99(7):452-6. Unique Identifier : AIDSLINE MED/98414943; Ohtani H; Tohoku University School of Medicine, Sendai, Japan.; The tumor-host relationship is one of the factors determining the biological behavior of malignant tumors. In colon cancer, the costimulatory molecules B7-1/B7-2 are expressed by macrophages distributed along the invasive margin (tumor-host interface). T-lymphocytes are also distributed in the same area with direct ce
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.: Mol Cell Biol. 1998 Oct;18(10):5888-98. Unique Identifier : AIDSLINE MED/98414605; Li W; Jiang YX; Zhang J; Soon L; Flechner L; Kapoor V; Pierce JH; Wang LH; Laboratory of Cellular and Molecular Biology, National Cancer; Institute, Bethesda, Maryland 20892, USA. Liwe@dc37a.nci.nih.gov; To investigate the potential role of protein kinase C-delta (PKC-delta) in insulin-like growth factor I receptor (IGF-IR)-mediated cell transformation, an oncogenic gag-IGF-IR beta-fusion receptor lacking the entire extracellular domain, which was designated NM1, and a full-length IGF-IR were coexpressed with either w
Mycoplasma fermentans DNA is infrequently detected in urine specimens from renal transplant recipients.: Mol Cell Probes. 1998 Aug;12(4):201-6. Unique Identifier : AIDSLINE MED/98396283; Coutlee F; Saint-Louis G; Voyer H; Daloze P; Ghadirian P; Departement de Microbiologie-Immunologie, Universite de; Montreal, Que., Canada.; Mycoplasma fermentans is a likely causative agent of HIV-associated nephropathy. In a pilot study, M. fermentans DNA was detected with polymerase chain reaction (PCR) in urine samples from renal allograft recipients; nine (39.1%) out of 23 renal allograft recipients (most of whom had chronic allograft rejection) and n
Direct quantitation of HIV by flow cytometry using branched DNA signal amplification.: Mol Cell Probes. 1998 Aug;12(4):243-7. Unique Identifier : AIDSLINE MED/98396290; Van Cleve M; Ostrerova N; Tietgen K; Cao W; Chang C; Collins ML; Kolberg J; Urdea M; Lohman K; Becton Dickinson Immunocytometry Systems, San Jose, CA 95131,; USA.; Adaptation of the branched DNA signal amplification technology to flow cytometry has resulted in a quantitative nuclei-acid assay with significant advantages over the microwell-based format. In this assay, microbeads, rather than microwell plates, are derivatized with nucleic-acid capture probes and the derivatized be
Parkinsonism with HIV infection.: Mov Disord. 1998 Jul;13(4):684-9. Unique Identifier : AIDSLINE MED/98349564; Mirsattari SM; Power C; Nath A; Department of Internal Medicine, University of Manitoba,; Winnipeg, Canada.; We describe six patients with parkinsonism and another 10 patients with parkinsonian features with human immunodeficiency virus (HIV) infection. In 50% of these patients, the symptoms were precipitated by neuroleptics. In the remaining patients, no obvious cause other than HIV infection was identified. Discontinuation
Maintenance antiretroviral therapies in HIV infected patients with undetectable plasma HIV RNA after triple-drug therapy. AIDS Clinical Trials Group Study 343 Team [see comments]: N Engl J Med. 1998 Oct 29;339(18):1261-8. Unique Identifier : AIDSLINE MED/99000298; Havlir DV; Marschner IC; Hirsch MS; Collier AC; Tebas P; Bassett RL; Ioannidis JP; Holohan MK; Leavitt R; Boone G; Richman DD; University of California, San Diego, and the San Diego Veterans; Affairs Medical Center, 92103, USA.; BACKGROUND: Combination antiretroviral therapy with indinavir , zidovudine, and lamivudine can suppress the level of human immunodeficiency virus (HIV) RNA in plasma below the threshold of detection for two years or more. We investigated whether a less
A randomized trial of three maintenance regimens given after three months of induction therapy with zidovudine, lamivudine, and indinavir in previously untreated HIV-1-infected patients. Trilege (Agence Nationale de Recherches sur le SIDA 072) Study Team [see comments]: N Engl J Med. 1998 Oct 29;339(18):1269-76. Unique Identifier : AIDSLINE MED/99000299; Pialoux G; Raffi F; Brun-Vezinet F; Meiffredy V; Flandre P; Gastaut JA; Dellamonica P; Yeni P; Delfraissy JF; Aboulker JP; Hopital de l'Institut Pasteur and Assistance Publique-Hopitaux; de Paris, France.; BACKGROUND: The long-term effectiveness of potent three-drug antiretroviral regimens for the treatment of human immunodeficiency virus type 1 (HIV-1) infection is limited by problems related to compliance and tolerability. We investigated whether two-drug maintenance therapy would suppress viral replication after a th
Images in clinical medicine. Lipodystrophy associated with an HIV-protease inhibitor.: N Engl J Med. 1998 Oct 29;339(18):1296. Unique Identifier : AIDSLINE MED/99000303; Carr A; Cooper DA; St. Vincent's Hospital, Sydney, Australia.
Images in clinical medicine. Buffalo hump in a patient with the acquired immunodeficiency syndrome.: N Engl J Med. 1998 Oct 29;339(18):1297. Unique Identifier : AIDSLINE MED/99000304; Aboulafia DM; Bundow D; Virginia Mason Clinic, Seattle, WA 98111, USA.
Therapeutic strategies for HIV infection--time to think hard [editorial; comment]: N Engl J Med. 1998 Oct 29;339(18):1319-21. Unique Identifier : AIDSLINE MED/99000307; Cooper DA; Emery S
Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients [see comments]: N Engl J Med. 1998 Nov 5;339(19):1358-63. Unique Identifier : AIDSLINE MED/99006596; Regamey N; Tamm M; Wernli M; Witschi A; Thiel G; Cathomas G; Erb P; Institute for Medical Microbiology, University of Basel,; Switzerland.; BACKGROUND: Human herpesvirus 8 (HHV-8) has been detected in all forms of Kaposi s sarcoma, including transplantation-associated Kaposi s sarcoma. To investigate the possibility of transmission of HHV-8 through allografts, we measured the seroprevalence of HHV-8 before and after renal transplantation. METHODS: Using a
Human herpesvirus 8--let the transplantation physician beware [editorial; comment]: N Engl J Med. 1998 Nov 5;339(19):1391-2. Unique Identifier : AIDSLINE MED/99006603; Ho M
Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus [see comments]: N Engl J Med. 1998 Nov 12;339(20):1409-14. Unique Identifier : AIDSLINE MED/99015390; Wade NA; Birkhead GS; Warren BL; Charbonneau TT; French PT; Wang L; Baum JB; Tesoriero JM; Savicki R; AIDS Institute, New York State Department of Health, Albany; 12237, USA.; BACKGROUND: The Pediatric AIDS Clinical Trials Group Protocol 076 reported a reduction in the rate of perinatal transmission of the human immunodeficiency virus (HIV) from 25.5 percent to 8.3 percent with a three-part regimen of zidovudine given ante partum, intra partum, and to the newborn. We examined the effects of
Short (and shorter) courses of zidovudine [editorial; comment]: N Engl J Med. 1998 Nov 12;339(20):1467-8. Unique Identifier : AIDSLINE MED/99015398; McIntosh K
Combination therapy for hepatitis C infection [editorial; comment]: N Engl J Med. 1998 Nov 19;339(21):1549-50. Unique Identifier : AIDSLINE MED/99025357; Liang TJ
[Assisted suicide after discharge from the psychiatric clinic]: Nervenarzt. 1997 Nov;68(11):903-6. Unique Identifier : AIDSLINE MED/98403271; Frei A; Hoffmann-Richter U; Bullinger A; Finzen A; Psychiatrische Universitatsklinik, Basel.; Assisted suicide has become a topic often and controversally discussed in international literature. Psychiatry and mentally ill, however, have been neglected, probably because the question of competence of judgement and will are a major issue in this matter. Two cases are reported, one of a 60-year old man and a women
Acute, relapsing brain oedema with diffuse blood-brain barrier alteration and axonal damage in the acquired immunodeficiency syndrome.: Neuropathol Appl Neurobiol. 1998 Jun;24(3):209-16. Unique Identifier : AIDSLINE MED/98382914; Gray F; Belec L; Chretien F; Dubreuil-Lemaire ML; Ricolfi F; Wingertsmann L; Poron F; Gherardi R; Laboratoire de Neuropathologie, Faculte de Medecine; Paris-Ouest, Garches, France.; A 38-year-old homosexual male with AIDS suffered four neurological episodes including headaches, confusion, visual impairment, memory disturbances, and dysarthria which resolved spontaneously in a few days. He was admitted to hospital during a fifth episode. Neurological examination revealed a cerebellar syndrome. Gen
The human immunodeficiency virus-1 envelope protein gp120 binds through its V3 sequence to the glycine site of N-methyl-D-aspartate receptors mediating noradrenaline release in the hippocampus.: Neuroscience. 1998 Nov;87(1):147-57. Unique Identifier : AIDSLINE MED/98387603; Pattarini R; Pittaluga A; Raiteri M; Department of Experimental Medicine, University of Genoa, Italy.; Recent results show that the HIV-1 protein gp120 can enhance N-methyl-D-aspartate receptor-mediated release of noradrenaline from CNS nerve endings. We now investigate the mechanism of this action, including the structural determinants of the gp120 effect and the nature of its binding sites. The N-methyl-D-aspartate-e
Elevated serum and CSF levels of soluble CD30 during clinical remission in multiple sclerosis.: Neurology. 1998 Oct;51(4):1156-60. Unique Identifier : AIDSLINE MED/98452807; McMillan SA; McDonnell GV; Douglas JP; Droogan AG; Hawkins SA; Regional Immunology Service, Royal Group of Hospitals, Belfast,; Northern Ireland.; OBJECTIVE: To ascertain the presence of the Th2 response in MS patients by evaluating the level of soluble (s) CD30 across the clinical spectrum of MS and during relapse and remission. BACKGROUND: MS is considered a T-cell-mediated disorder with the immune attack dominated by a Thl cytokine response. Elevated levels o
Dual infective pathology in patients with cryptococcal meningitis.: Neurology. 1998 Oct;51(4):1213-5. Unique Identifier : AIDSLINE MED/98452826; Silber E; Sonnenberg P; Koornhof HJ; Morris L; Saffer D; Department of Neurology, Baragwanath Hospital and University of; the Witwatersrand, Johannesburg, South Africa.; Coinfection of the nervous system by two distinct nonviral organisms is uncommon and often undiagnosed. Medical teaching emphasizes that a single pathologic process should be sought; however, in the presence of severe immunocompromise this approach may not hold true. We describe seven HIV-1 seropositive patients with
Evaluation and management of intracranial mass lesions in AIDS: Report of the Quality Standards Subcommittee of the American Academy of Neurology [letter]: Neurology. 1998 Oct;51(4):1232; discussion 1233-4. Unique Identifier : AIDSLINE MED/98452839; Gildenberg PL
Evaluation and management of intracranial mass lesions in AIDS: Report of the Quality Standards Subcommittee of the American Academy of Neurology [letter]: Neurology. 1998 Oct;51(4):1232; discussion 1233-4. Unique Identifier : AIDSLINE MED/98452838; Goldman HB
Evaluation and management of intracranial mass lesions in AIDS: Report of the Quality Standards Subcommittee of the American Academy of Neurology [letter]: Neurology. 1998 Oct;51(4):1232-3; discussion 1233-4. Unique Identifier : AIDSLINE MED/98452840; Brew BJ
Evaluation and management of intracranial mass lesions in AIDS: Report of the Quality Standards Subcommittee of the American Academy of Neurology [letter]: Neurology. 1998 Oct;51(4):1233-4. Unique Identifier : AIDSLINE MED/98452841; Antinori A
Human immunodeficiency virus (HIV) education and HIV risk behavior: a survey of rapid deployment troops.: Mil Med. 1998 Oct;163(10):672-6. Unique Identifier : AIDSLINE MED/99011634; Nannis ED; Schneider S; Jenkins PR; Sharp-Breslau E; Daniell FD; McKee KT Jr; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, MD 20852, USA.; A paper-and-pencil questionnaire was administered to 1,377 U.S. Army troops from rapid deployment units at Fort Bragg, North Carolina. This yielded 1,368 surveys available for analysis. The primary goal of the survey was to evaluate this group s experience with the Army human immunodeficiency virus (HIV) education pro
Epstein-Barr-virus-induced interstitial nephritis in an HIV-positive patient with progressive renal failure.: Nephrol Dial Transplant. 1998 Jul;13(7):1849-52. Unique Identifier : AIDSLINE MED/98345071; Frazao JM; Elangovan L; Felsenfeld AJ; Stanley TM; Cohen AH; Department of Medicine, West Los Angeles Veterans Affairs Medical; Center, CA 90073, USA.
The nef protein of the human immunodeficiency virus type 1 (HIV-1) inhibits a large-conductance potassium channel in human glial cells.: Neurosci Lett. 1998 Jul 17;251(1):1-4. Unique Identifier : AIDSLINE MED/98378252; Kort JJ; Jalonen TO; Department of Medicine, Albany Medical College, NY 12208, USA.; jkort@ccgateway.amc.edu; The Nef protein of human immunodeficiency virus type 1 (HIV-1) is abundantly expressed in HIV-1-infected astrocytes and shares amino acid sequence homology to alpha-scorpion toxins which bind to potassium channels. Here we report effects of recombinant Nef and alpha-scorpion toxins on membrane potassium transport in h
Postsexual exposure prophylaxis [news]: Nurse Pract. 1998 Aug;23(8):70, 72-3. Unique Identifier : AIDSLINE MED/98384715; Klaus BD; Grodesky MJ
HIV infection in women in New Zealand [news]: N Z Med J. 1998 Aug 28;111(1072):329. Unique Identifier : AIDSLINE MED/98438780
Successful pregnancy in an adolescent with perinatally acquired human immunodeficiency virus.: Obstet Gynecol. 1998 Oct;92(4 Pt 2):711. Unique Identifier : AIDSLINE MED/98435707; Crane S; Sullivan M; Feingold M; Kaufman GE; Department of Infectious Disease, Boston Medical Center,; Massachusetts, USA.
Telemedicine diagnosis of eye disorders by direct ophthalmoscopy. A pilot study.: Ophthalmology. 1998 Oct;105(10):1907-14. Unique Identifier : AIDSLINE MED/99003631; Marcus DM; Brooks SE; Ulrich LD; Bassi FH; Laird M; Johnson M; Newman C; Department of Ophthalmology, Medical College of Georgia, Augusta; 30912-3400, USA.; OBJECTIVE: To report a pilot study of telemedical direct ophthalmoscopy in the diagnosis of acquired immune deficiency syndrome (AIDS)-related retinopathy in a human immunodeficiency virus (HIV)-positive population and in the diagnosis of glaucoma, cataract, and retinopathy in a diabetic population. DESIGN: Prospectiv
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.: Oncogene. 1998 Aug 20;17(7):913-8. Unique Identifier : AIDSLINE MED/98451288; Kumar A; Dhawan S; Aggarwal BB; Department of Molecular Oncology, The University of Texas MD; Anderson Cancer Center, Houston 77030, USA.; Most inflammatory agents activate nuclear transcription factor-kappaB (NF-kappaB) which results in expression of genes for cytokines, adhesion molecules, and enzymes involved in amplification and perpetuation of inflammation. Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) is an active component from the roots of Poly
Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer.: Otolaryngol Head Neck Surg. 1998 Oct;119(4):412-7. Unique Identifier : AIDSLINE MED/98453265; Tisch M; Heimlich F; Daniel V; Opelz G; Maier H; Department of Otorhinolaryngology-Head and Neck Surgery, Armed; Forces Hospital, Ulm, Germany.; The effects of locoregional postoperative radiation therapy (60 Gy on average) on cellular immunity were investigated in 11 patients with squamocellular carcinomas of the oral cavity, pharynx, or larynx. During radiation treatment, the total lymphocyte counts, CD8+ T-lymphocyte count, and especially CD4+ T-lymphocyte
The effect of anti-IL-10 on proliferation and cytokine production in human schistosomiasis: fresh versus cryopreserved cells.: Parasite Immunol. 1998 Jul;20(7):345-9. Unique Identifier : AIDSLINE MED/98382924; Grogan JL; Kremsner PG; Deelder AM; Yazdanbakhsh M; Department of Parasitology, Leiden University, Lieden University; Medical Centre, The Netherlands.; In this study we neutralized endogenous IL-10 in PBMC from individuals chronically infected with Schistosoma haematobium by using anti-IL-10 MoAbs, and examined the effect and adult worm antigen (AWA)-specific responses in both fresh or cryopreserved cells. Anti-IL-10 alone increased background proliferation of PBMC,
Murine immune responses to Schistosoma haematobium and the vaccine candidate rSh28GST.: Parasite Immunol. 1998 Aug;20(8):359-67. Unique Identifier : AIDSLINE MED/98440768; Lane A; Boulanger D; Riveau G; Capron A; Wilson RA; Department of Biology, University of York, PO BOX 373, York YO1; 5YW, UK.; Longitudinal studies of Schistosoma haematobium infection in CBA mice revealed a progressive down-regulation of cellular immune responses, as measured by mitogenic and antigenic stimulation of in vitro lymphocyte cultures. Antigen-stimulated production of the Th1 cytokine IFN-gamma by splenocytes increased progressive
T cell responses in coinfection with Onchocerca volvulus and the human immunodeficiency virus type 1.: Parasite Immunol. 1998 Sep;20(9):431-9. Unique Identifier : AIDSLINE MED/98440653; Sentongo E; Rubaale T; Buttner DW; Brattig NW; Department of Helminthology, Bernhard Nocht Institute for; Tropical Medicine, Hamburg, Germany.; Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda . To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and c
[Topicality of serologic screening of human immunodeficiency virus infections in adults]: Pathol Biol (Paris). 1998 Jan;46(1):61-6. Unique Identifier : AIDSLINE MED/98442074; Dubrous P; Koeck JL; Coulot P; Blanchard de Vaucouleurs A; Laboratoire de Sero-Immuno-Hematologie, Centre de Transfusion; Sanguine des Armees Jean Julliard, Clamart, France.; Enzyme immunoassay is the basic method for the detection of antibodies to the Human Immunodeficiency Virus (HIV). In spite of the apparent facility of the serological screening, the difficulties are real at all stages of the analysis. Specimen treatment needs defined rules to avoid contamination. The products authoriz
[Contribution of ParaSight F to the diagnosis of Plasmodium falciparum malaria]: Pathol Biol (Paris). 1998 May;46(5):301-6. Unique Identifier : AIDSLINE MED/98442025; Bellagra N; Ajana F; Caillaux M; Service de Parasitologie-Mycologie, Centre Hospitalier de; Tourcoing, France.; The ParaSight F is a new diagnostic test for Plasmodium falciparum infections and is based on the detection of a trophozoite-derived antigen, the histidine rich protein II (HRP-II). To assess the usefulness of this test, we conducted a prospective study and analyzed 62 blood specimens from 38 patients, using thin bloo
Oropharyngeal candidiasis in AIDS patients from Abidjan (Ivory Coast): antifungal susceptibilities and multilocus enzyme electrophoresis analysis of Candida albicans isolates.: Pathol Biol (Paris). 1998 May;46(5):307-14. Unique Identifier : AIDSLINE MED/98442026; Nebavi F; Arnavielhe S; Le Guennec R; Menan E; Kacou A; Combe P; Aoussi E; Mallie M; Kone M; Bastide JM; Laboratoire d'Immunologie et Parasitologie, Faculte de; Pharmacie, Montpellier, France.; Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used to investigate the Candida albicans strain diversity in twenty nine AIDS patients from Abidjan ( Ivory Coast ). All patients were monitored for a first episode of oropharyngeal candi
[Multifocal tuberculosis. Apropos of 49 cases in the midwest region. GERICCO (Group for Epidemiology and Research in Clinical Infections of the Central West of France), 1991-1993.: Pathol Biol (Paris). 1998 Jun;46(6):375-9. Unique Identifier : AIDSLINE MED/98442000; Denis-Delpierre N; Merrien D; Billaud E; Besnier JM; Duhamel E; Hutin P; Andrieux F; Delaunay C; Rogez JP; Arsac P; Chennebault JM; Raffi F; Service de Medecine Interne, Maladies Infectieuses et; Tropicales, Hotel Dieu, CHU Nantes, France.; Diffuse or multifocal tuberculosis (TB) accounts for 9% to 10% of cases of extrapulmonary TB and carries a poor prognosis with a mortality rate of 16% to 25%. Forty-nine cases of multifocal TB defined as involvement of two extrapulmonary sites with or without pulmonary TB were reviewed. Mean patient age (+/- SD) was 5
[Systematic detection of toxigenic strains of Clostridium difficile--is it useful?]: Pathol Biol (Paris). 1998 Jun;46(6):395-7. Unique Identifier : AIDSLINE MED/98442003; Honderlick P; Cahen P; Service de Microbiologie, Hopital Foch, Suresnes, France.; The incidence of Clostridium difficile (Cd) infection is rising and Cd in fact is now endemic in many hospitals. During the past 4 years we analyzed our data concerning diarrhea caused by Cd in our 700 beds hospital. A positive case was defined as a Cd cytotoxine positive with or without positive culture for Cd. In th
[Effects of double and triple antiretroviral agents on the HCV viral load in patients coinfected with HIV and HCV]: Pathol Biol (Paris). 1998 Jun;46(6):412-5. Unique Identifier : AIDSLINE MED/98442007; Gavazzi G; Richallet G; Morand P; Bouchard O; Bosseray A; Leclercq P; Micoud M; Service de Medecine Interne et Maladies Infectieuses, CHU A.; Michallon, Grenoble, France.; HIV infection accelerates natural course of HCV infection, but impact of antiretroviral treatment on HCV infection is not well known. The aim of this study is to compare the change of HCV viral load in patients on combination of 2 nucleoside analogues and in patients on combination of 2 nucleoside analogues and protea
[Invasive pulmonary aspergillosis in AIDS]: Pathol Biol (Paris). 1998 Jun;46(6):416-7. Unique Identifier : AIDSLINE MED/98442008; Darras-Joly C; Lucet JC; Laissy JP; Chochillon C; Casalino E; Joly V; Matheron S; Bouvet E; Service de Medecine Interne, Hopital Pitie-Salpetriere,; Paris, France.; Risk factor for invasive pulmonary aspergillosis in HIV-negative patients include neutropenia, corticosteroid therapy, and chemotherapy. Corresponding risk factors in HIV-positive patients have not yet been reported. A case-control study was conducted at the Bichat-Claude Bernard Teaching Hospital, Paris,
[Importance of antiproteases in the treatment of microsporidia and/or cryptosporidia infections in HIV-seropositive patients]: Pathol Biol (Paris). 1998 Jun;46(6):418-9. Unique Identifier : AIDSLINE MED/98442009; Bobin S; Bouhour D; Durupt S; Boibieux A; Girault V; Peyramond D; Service des Maladies Infectieuses et Tropicales, Hopital; Croix-Rousse, Lyon, France.; Diarrhea due to infection with Microsporidium (M) or Cryptosporidium (C) raises significant therapeutic challenges in HIV-infected patients. The usefulness of protease inhibitor therapy was evaluated in 20 HIV-positive patients with positive tests for M and/or C. There were 17 men and three women with a mean age of 42
[Clinical importance of the quantification of HIV-1 RNA in cerebrospinal fluid for the diagnosis of HIV encephalitis]: Pathol Biol (Paris). 1998 Jun;46(6):423-5. Unique Identifier : AIDSLINE MED/98442011; Bossi P; Dupre S; Dupin N; Coutellier A; Bricaire F; Lubetzki C; Katlama C; Calvez V; Service de Virologie, Hopital Pitie-Salpetriere, Paris,; France.; We evaluated prospectively the HIV-1 RNA level in CSF as a marker of HIV encephalitis diagnosis. 110 HIV-1 infected patients (mean age: 39 years; sex-ratio M/F: 94/16) were tested for HIV-1 RNA in plasma and CSF. Lumbar punctures were performed to explore cognitive deficit, seizure or fever. HIV encephalitis was diagn
Cryptococcal myositis: a case report and review of the literature.: Pathology. 1998 Aug;30(3):316-7. Unique Identifier : AIDSLINE MED/98442337; O'Neill KM; Ormsby AH; Prayson RA; Department of Neurology, Cleveland Clinic Foundation, Ohio, USA.; Only rare cases of cryptococcal myositis have been previously reported in the literature. All of these cases have occurred in the setting of human immunodeficiency virus (HIV) infection. We report a case of cryptococcal myositis diagnosed premortem on a needle biopsy in a heart transplant patient undergoing immunosupp
Neurologic complications of HIV infections in children.: Pediatr Ann. 1998 Oct;27(10):635-9. Unique Identifier : AIDSLINE MED/99014977; Zuckerman GB; Sanchez JL; Conway EE Jr; Department of Pediatrics, Robert Wood Johnson Medical School, New; Brunswick, New Jersey, USA.
CD28 expression in pediatric human immunodeficiency virus infection.: Pediatr Res. 1998 Aug;44(2):265-8. Unique Identifier : AIDSLINE MED/98366485; Niehues T; Ndagijimana J; Horneff G; Wahn V; Department of Pediatrics, Heinrich Heine University Dusseldorf,; Germany.; Increased apoptosis of lymphocytes represents a key event of immune destruction in HIV infection. In this study it was investigated at which stage of the disease and in which T lymphocyte subpopulation (CD4+ or CD8+) protection against apoptosis may be lost as measured by decreased CD28 expression. In 26 HIV-infected
Pediatric visceral leishmaniasis in southern France.: Pediatr Infect Dis J. 1998 Aug;17(8):701-4. Unique Identifier : AIDSLINE MED/98392945; Minodier P; Piarroux R; Garnier JM; Unal D; Perrimond H; Dumon H; Service of Pediatrics, CHU Nord, Marseille, France. c gire@ ap hm; fr; PURPOSE: The purposes of this study were to describe the characteristics of pediatric visceral leishmaniasis in southern France and to evaluate a new scheme of therapy. METHODS: Hospital records of 59 children with visceral leishmaniasis were retrospectively reviewed. The period of
Early experience with protease inhibitors in human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1998 Aug;17(8):728-38. Unique Identifier : AIDSLINE MED/98392950; Saez-Llorens X; Ramilo O; Division of Infectious Diseases, Hospital del Nino, Panama City,; Panama.
Neuroimaging findings in children perinatally infected with the human immunodeficiency virus.: Pediatr Infect Dis J. 1998 Aug;17(8):753-4. Unique Identifier : AIDSLINE MED/98392956; Johann-Liang R; Lin K; Cervia J; Stavola J; Noel G; Pediatric Infectious Diseases, Cornell University Medical; College, New York, NY 10021, USA. rjohannliang@pol.net
Effect of superimposed infections on viral replication in human immunodeficiency virus type 1-infected children.: Pediatr Infect Dis J. 1998 Aug;17(8):755-7. Unique Identifier : AIDSLINE MED/98392957; Marchisio P; Esposito S; Zanchetta N; Tornaghi R; Gismondo MR; Principi N; Pediatric Department 4, University of Milan Medical School,; Italy. march@imiucca.csi.unimi.it
The influence of 3TC-resistance mutations E89G and M184V in the human immunodeficiency virus reverse transcriptase on mispair extension efficiency.: Nucleic Acids Res. 1998 Oct 1;26(19):4389-94. Unique Identifier : AIDSLINE MED/98416195; Hamburgh ME; Drosopoulos WC; Prasad VR; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461,; USA.; Two nucleoside analog resistance mutations in HIV-1 reverse transcriptase (RT), E89G and M184V, were previously shown to increase the dNTP insertion fidelity of HIV-1 RT. However, forward mutation assays using a lacZ alpha reporter gene have revealed a lack of impact on the overall error rate of these variants. In an
Is it over yet? Hope or hype: status of the HIV/AIDS pandemic.: Nurs Outlook. 1998 Jul-Aug;46(4):155-6. Unique Identifier : AIDSLINE MED/98411848; Miramontes HM; Corless IB; International Center for HIV/AIDS Research and Clinical Training,; School of Nursing, University of California, San Francisco, USA.
Cinderella no more [interview by Rebecca Coombes]: Nurs Times. 1998 Jun 3-9;94(22):16-7. Unique Identifier : AIDSLINE MED/98352410; Dicks B
Thalidomide: is it any wonder?: Nurs Times. 1998 Aug 26-Sep 1;94(34):14-5. Unique Identifier : AIDSLINE MED/99007715; Hampshire M
[Myelodysplastic syndromes (MDS): definition, classification and clinical course]: Pol Arch Med Wewn. 1998 Feb;99(2):96-103. Unique Identifier : AIDSLINE MED/98351128; Kotlarek-Haus S; Katedra i Klinika Hematologii i Chorob Rozrostowych, Akademii; Medycznej we Wroclawiu.
Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients.: Peptides. 1998;19(6):1099-104. Unique Identifier : AIDSLINE MED/98366118; Catania A; Garofalo L; Cutuli M; Gringeri A; Santagostino E; Lipton JM; Third Division of Internal Medicine, IRCCS Ospedale Maggiore,; Milano, Italy. Anna.Catania@unimi.it; Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1-39)], alpha-melanocyte-stimulating hormone [alpha-MSH (1-13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interleukin 1 (IL
Primary pulmonary hypertension associated with human immunodeficiency virus infection.: Postgrad Med J. 1998 Jul;74(873):400-4. Unique Identifier : AIDSLINE MED/99016292; Golpe R; Fernandez-Infante B; Fernandez-Rozas S; Respiratory Section, University Hospital Marques de Valdecilla,; Santander, Spain.; Several cardiorespiratory diseases can complicate human immunodeficiency virus infection. Primary pulmonary hypertension is a rare clinical disorder which carries a bad prognosis. More than 90 cases of HIV-associated primary pulmonary hypertension have been reported to date. Although its pathogenesis remains unknown,
Therapeutic opportunities from the pharmacological manipulation of the Fas system.: Pharmacol Res. 1998 Jul;38(1):1-34. Unique Identifier : AIDSLINE MED/98362477; Maggi CA; Direzione Discovery, Menarini Ricerche, Florence, Italy.
[Septic arthritis in AIDS. 10 cases (letter)]: Presse Med. 1998 Mar 21;27(11):521. Unique Identifier : AIDSLINE MED/98441077; Bileckot R; Missengue A
[Antibodies against cytomegalovirus and risk of hepatitis C (letter)]: Presse Med. 1998 Apr 4;27(13):617. Unique Identifier : AIDSLINE MED/98441051; Moncharmont P; Degottex J; Rigal D
[5th Conference on Opportunistic Retrovirus Infections in HIV: contribution of anti-retroviral combinations]: Presse Med. 1998 Apr 4;27(13):622-3. Unique Identifier : AIDSLINE MED/98441053; Granier F; Valantin MA; CHU Pitie-Salpetriere-Paris.
[Osteoarticular Mycobacterium xenopi infection]: Presse Med. 1998 May 2-9;27(17):800-3. Unique Identifier : AIDSLINE MED/98440997; Ollagnier E; Fresard A; Guglielminotti C; Carricajo A; Mosnier JF; Alexandre C; Lucht F; Service de Rhumatologie, Hopital de Bellevue, CHU de; Saint-Etienne.; BACKGROUND: Mycobacterium xenopi is a potential pathogen for man and can cause bone and joint infections, particularly spondylodiscitis. Most cases of infection occur in fragilized patients and are found more and more often in AIDS patients. CASE REPORT: A 41-year-old HIV+ woman developed cervical spondylodiscitis due
[HIV arthritis: an entity apart from HIV infection (letter)]: Presse Med. 1998 May 2-9;27(17):806-7. Unique Identifier : AIDSLINE MED/98441000; Bileckot R; Mouaya A
[Anterior uveitis in HIV-infected patients. 3 cases in patients treated with an antiprotease]: Presse Med. 1998 May 16;27(18):844-8. Unique Identifier : AIDSLINE MED/98440981; Fournier S; Deplus S; Janier M; Poinsignon Y; Decazes JM; Modai J; Clinique de Maladies Infectieuses et tropicales, Hopital Saint; Louis, Paris.; OBJECTIVES: Uveitis is an ocular manifestation rarely observed in HIV-infected patients. We observed three cases of anterior uveitis without progressive retinitis in HIV patients receiving antiprotease treatment. CASE REP