1999

[Complications with permanent damage in endonasal paranasal sinus operations--more frequent in experienced surgeons?]: Laryngorhinootologie. 1998 Jul;77(7):398-401. Unique Identifier : AIDSLINE MED/98416621; Weber R; Keerl R; Hosemann W; Schauss F; Leuwer R; Draf W; Klinik fur HNO-Krankheiten, Kopf-, Hals- und Plastische; Gesichtschirurgie, Kommunikationsstorungen, Klinikum Fulda.; BACKGROUND: The rate of serious complications in endonasal sinus surgery has not gone down although optical aids are widely used nowadays. Are serious complications caused more often by unexperienced or experienced surgeons using a microscope and/or endoscope? METHODS: We defined serious complications as follows: deat
Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental autoimmune neuritis in Lewis rats.: J Autoimmun. 1998 Aug;11(4):319-27. Unique Identifier : AIDSLINE MED/98451615; Zhu J; Bengtsson BO; Mix E; Ekerling L; Thorell LH; Olsson T; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, Stockholm, Sweden. Jie.Zhu@cnsf.ki.se; 5-Hydroxytryptamine (5-HT) reuptake inhibitors of the zimeldine-type have induced polyneuropathies similar to Guillain-Barre syndrome (GBS) in patients with endogenous depression. Some monoamine neurotransmitters have been shown to affect immune reactions in vivo and in vitro in a concentration-dependent manner. We th
Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats.: J Autoimmun. 1998 Aug;11(4):329-34. Unique Identifier : AIDSLINE MED/98451616; Chelmicka-Schorr E; Wiegmann K; Wollmann R; Arnason BG; Kim DH; Department of Neurology, University of Chicago, 5841 S. Maryland; Avenue, Chicago, IL, 60637, USA.; The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse
AIDS talks for adolescents.: World Health Forum. 1998;19(3):294-7. Unique Identifier : AIDSLINE MED/99002232; Manuel C; Molines C; Dubuc M; San Marco JL; Public Health Laboratory, Faculty of Medicine, Universite Aix; Marseille II, France.; The authors discuss how to conduct information sessions on AIDS prevention for adolescents on the basis of experience gained in Marseilles secondary schools. Precautionary messages have to be conveyed without encouraging irrational fear and intolerance.
The immunology of reproduction: update 1998.: Immunol Today. 1998 Oct;19(10):433-4. Unique Identifier : AIDSLINE MED/99001840; Gupta SK; Gamete Antigen Laboratory, National Institute of Immunology,; Aruna Asaf Ali Marg, New Delhi, India.
Granulomatous inflammation and the transmission of infection: schistosomiasis--and TB too?: Immunol Today. 1998 Oct;19(10):462-7. Unique Identifier : AIDSLINE MED/99001849; Doenhoff MJ; School of Biological Sciences, University of Wales, Bangor,; Gwynedd, UK. m.doenhoff@bangor.ac.uk; Immune-dependent granulomatous inflammation is important in the pathogenesis of both schistosomiasis and tuberculosis. A case has previously been made for a role for schistosome egg-induced granulomas in the onward transmission of infection. Here, Mike Doenhoff suggests that a similar hypothesis applies to tuberculosi
Anti-apoptotic strategies of lymphotropic viruses.: Immunol Today. 1998 Oct;19(10):474-9. Unique Identifier : AIDSLINE MED/99001851; Meinl E; Fickenscher H; Thome M; Tschopp J; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany. ermeinl@viro.med.uni-erlangen.de; Induction of apoptosis of virus-infected cells is an important host cell defence mechanism. However, some viruses have incorporated genes that encode anti-apoptotic proteins or modulate the expression of cellular regulators of apoptosis. Here, Edgar Meinl and colleagues discuss recent evidence that viral interference
Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.: Biofactors. 1998;8(1-2):129-32. Unique Identifier : AIDSLINE MED/98364176; Jareno EJ; Bosch-Morell F; Fernandez-Delgado R; Donat J; Romero FJ; Department of Physiology, School of Medicine and Dentistry,; University of Valencia, Spain.; Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0
Role of cysteine and glutathione in signal transduction, immunopathology and cachexia.: Biofactors. 1998;8(1-2):97-102. Unique Identifier : AIDSLINE MED/98364172; Droge W; Hack V; Breitkreutz R; Holm E; Shubinsky G; Schmid E; Galter D; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Abnormally low plasma cystine levels have been found in the late asymptomatic stage of HIV infection and several other diseases associated with progressive loss of skeletal muscle mass. The phenomenon is commonly associated with a low NK cell activity, skeletal muscle wasting or muscle fatigue and increased rates of u
Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3'-azido-2',3'-dideoxythymidine.: Mol Carcinog. 1998 Sep;23(1):45-51. Unique Identifier : AIDSLINE MED/98437827; Zhang Z; Diwan BA; Anderson LM; Logsdon D; Olivero OA; Haines DC; Rice JM; Yuspa SH; Poirier MC; Laboratory of Cellular Carcinogenesis and Tumor Promotion,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892-4255, USA.; This study was designed to evaluate the potential initiating effects of transplacental 3 -azido-2 ,3 -dideoxythymine ( AZT ) and the role of ras mutational activation in skin tumors induced in a two-stage mouse skin model. In addition, mouse liver and l
Crossregulation between Th1 and Th2 cells.: Crit Rev Immunol. 1998;18(4):275-303. Unique Identifier : AIDSLINE MED/98369814; Morel PA; Oriss TB; Department of Medicine, University of Pittsburgh, PA, USA.; Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2 , IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL
Positive and negative thymocyte selection.: Crit Rev Immunol. 1998;18(4):359-70. Unique Identifier : AIDSLINE MED/98369817; Saito T; Watanabe N; Department of Molecular Genetics, Chiba University, Graduate; School of Medicine, Japan.; T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pT alpha and TCR beta chains, which plays a role in allelic exclusion of TCR beta and promotion from DN to DP transition. During the DP stag
T cells in mouse models of gut inflammation.: Chem Immunol. 1998;71:118-38. Unique Identifier : AIDSLINE MED/98448622; Simpson SJ; de Jong YP; Comiskey M; Terhorst C; Division of Immunology, Beth Israel Deaconess Medical Center,; Boston, Mass., USA.
Th1 and Th2 cells and immunity to intestinal helminths.: Chem Immunol. 1998;71:192-208. Unique Identifier : AIDSLINE MED/98448626; Bancroft AJ; Grencis RK; School of Biological Sciences, University of Manchester, UK.; abancrof@fs1.scg.man.ac.uk
Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent.: DNA Cell Biol. 1998 Sep;17(9):735-42. Unique Identifier : AIDSLINE MED/98449462; Zhang L; Chiu J; Lin JC; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.; Human herpesvirus 8 (HHV-8) is a newly discovered virus closely associated with Kaposi s sarcoma and primary effusion lymphomas. When they occur in patients with AIDS, these B-cell lymphomas frequently harbor another human herpesvirus, Epstein-Barr virus (EBV). To determine the molecular mechanisms of the regulation o
Antiretroviral chemotherapy.: Curr Clin Top Infect Dis. 1998;18:154-79. Unique Identifier : AIDSLINE MED/98452390; Saag MS; Schooley RT; Division of Infectious Diseases, University of Alabama at; Birmingham, USA.
Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma.: Curr Clin Top Infect Dis. 1998;18:237-51. Unique Identifier : AIDSLINE MED/98452394; Ganem D; University of California, San Francisco, USA.
New perspectives in adenoviruses.: Curr Clin Top Infect Dis. 1998;18:286-305. Unique Identifier : AIDSLINE MED/98452397; Lukashok SA; Horwitz MS; Emory University School of Medicine, Division of Infectious; Diseases, Atlanta, Georgia, USA.
Infectious tolerance.: Curr Opin Immunol. 1998 Oct;10(5):518-24. Unique Identifier : AIDSLINE MED/99014155; Cobbold S; Waldmann H; Sir William Dunn School of Pathology, South Parks Road, Oxford,; OX1 3RE, UK. stephen.cobbold@pathology.ox.ac.uk; Infectious tolerance can be induced in many ways, does not require a thymus or clonal deletion and can spread to third-party antigens linked on the same antigen-presenting cell-the process being variously described as linked-, bystanderor epitope-suppression. We here review the evidence concerning the mechanisms invol
Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients. NV15355 Study Team.: AIDS. 1998 Jul 30;12(11):F103-9. Unique Identifier : AIDSLINE MED/98372104; Mitsuyasu RT; Skolnik PR; Cohen SR; Conway B; Gill MJ; Jensen PC; Pulvirenti JJ; Slater LN; Schooley RT; Thompson MA; Torres RA; Tsoukas CM; University of California, Los Angeles, USA.; OBJECTIVE: A Phase II, open-label, randomized, parallel-arm, multicentre trial to compare the antiviral activity and safety of two formulations of saquinavir (SQV), soft gelatin (SQV-SGC) and hard gelatin (SQV-HGC) capsules, in combination with two nucleoside reverse transcriptase inhibitors (NRTI), in antiretroviral-
The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy.: AIDS. 1998 Jul 30;12(11):F111-5. Unique Identifier : AIDSLINE MED/98372105; Hoetelmans RM; Reijers MH; Weverling GJ; ten Kate RW; Wit FW; Mulder JW; Weigel HM; Frissen PH; Roos M; Jurriaans S; Schuitemaker H; de Wolf F; Beijnen JH; Lange JM; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; OBJECTIVE: To investigate the relationship between exposure to antiretroviral drugs and the initial decline of plasma HIV-1 RNA. DESIGN: Open-label study in antiretroviral-naive HIV-1 infected patients using a quadruple drug regimen [nelfinavir (NFV), saquinavir (SQV),
Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy.: AIDS. 1998 Jul 30;12(11):F117-22. Unique Identifier : AIDSLINE MED/98372106; Weverling GJ; Lange JM; Jurriaans S; Prins JM; Lukashov VV; Notermans DW; Roos M; Schuitemaker H; Hoetelmans RM; Danner SA; Goudsmit J; de Wolf F; National AIDS Therapy Evaluation Centre, Department of Internal; Medicine, University of Amsterdam, The Netherlands.; OBJECTIVE: To compare the viral suppression of two antiretroviral regimens using three drugs or five drugs. DESIGN: Two open-label studies using a three-drug (zidovudine, lamivudine and ritonavir ) and a five-drug regimen (zidovudine, lamivudine,
Early reduction of immune activation in lymphoid tissue following highly active HIV therapy.: AIDS. 1998 Jul 30;12(11):F123-9. Unique Identifier : AIDSLINE MED/98372107; Andersson J; Fehniger TE; Patterson BK; Pottage J; Agnoli M; Jones P; Behbahani H; Landay A; Division of Infectious Diseases, Karolinska Institute, Stockholm,; Sweden.; OBJECTIVE: To evaluate immune reconstitution within HIV-infected lymphoid tissue during highly active antiretroviral therapy (HAART). DESIGN AND METHODS: In situ cellular responses were studied in sequential tonsillar biopsies in three asymptomatic HIV-infected (CD4 cells greater than 400 x 10(6)/l) antiretroviral tre
Predictors of long-term response to protease inhibitor therapy in a cohort of HIV-infected patients.: AIDS. 1998 Jul 30;12(11):F131-5. Unique Identifier : AIDSLINE MED/98372108; Casado JL; Perez-Elias MJ; Antela A; Sabido R; Marti-Belda P; Dronda F; Blazquez J; Quereda C; Infectious Diseases Unit, Ramon y Cajal Hospital, Madrid, Spain.; OBJECTIVE: To assess the rate of long-term effectiveness and factors associated with response to protease inhibitor therapy in a cohort of HIV-infected patients. DESIGN AND SETTING: Prospective, non-randomized study in a tertiary care centre. PATIENTS: A total of 400 HIV-infected patients who started on protease inhib
Long-term follow-up of randomized trials of immediate versus deferred zidovudine in symptom-free HIV infection. Joint Concorde and Opal Coordinating Committee [editorial]: AIDS. 1998 Jul 30;12(11):1259-65. Unique Identifier : AIDSLINE MED/98372109
Changes in blood CD8+ lymphocyte activation status and plasma HIV RNA levels during antiretroviral therapy.: AIDS. 1998 Jul 30;12(11):1267-73. Unique Identifier : AIDSLINE MED/98372110; Bouscarat F; Levacher M; Landman R; Muffat-Joly M; Girard PM; Saimot AG; Brun-Vezinet F; Sinet M; INSERM Unite 13, Hopital Bichat-Claude Bernard, Paris, France.; OBJECTIVE: To analyse the relationship between CD8+ lymphocyte phenotype alterations and plasma HIV RNA levels in HIV-infected patients treated with the zidovudine-didanosine combination. METHODS: A total of 30 HIV-infected patients who had never received antiretroviral therapy and who were starting treatment with a c
HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.: AIDS. 1998 Jul 30;12(11):1275-84. Unique Identifier : AIDSLINE MED/98372111; Milani D; Mazzoni M; Zauli G; Mischiati C; Gibellini D; Giacca M; Capitani S; Department of Morphology and Embriology, University of Ferrara,; Italy.; OBJECTIVE: To evaluate the signal transduction potential of HIV-1 Tat in a neuronal cell model. METHODS: The tyrosine phosphorylation levels of the focal adhesion kinase p125FAK and its association with phosphoinositide 3-kinase (PI 3-K) were evaluated in serum-starved rat pheochromocytoma PC12 cells, either treated w
Lack of evidence of a stable viral load set-point in early stage asymptomatic patients with chronic HIV-1 infection.: AIDS. 1998 Jul 30;12(11):1285-9. Unique Identifier : AIDSLINE MED/98372112; Vidal C; Garcia F; Romeu J; Ruiz L; Miro JM; Cruceta A; Soriano A; Pumarola T; Clotet B; Gatell JM; Institut d'Investigacions Biomediques August Pi I Sunyer,; Hospital Clinic, Faculty of Medicine, University of Barcelona,; Spain.; OBJECTIVE: To address the question of whether individuals with chronic HIV-1 infection have a stable viral load set-point and to assess the influence of host and viral factors on the evolution of viral load in a subset of stable asymptomatic patients with a baseline viral load below 5000 copies/ml and CD4+ T-cell coun
Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen. DATRI 010 Study Group. Division of AIDS Treatment Research Initiative.: AIDS. 1998 Jul 30;12(11):1291-300. Unique Identifier : AIDSLINE MED/98372113; Bartlett JA; Wasserman SS; Hicks CB; Dodge RT; Weinhold KJ; Tacket CO; Ketter N; Wittek AE; Palker TJ; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; OBJECTIVE: To evaluate the safety and immunogenicity of a polyvalent (PV) HIV envelope synthetic peptide immunogen, C4-V3. The immunogen comprised four peptides containing T-helper epitopes from the fourth constant region (C4) of gp120 of HIV-1MN, and T-helper, cytotoxic T-lymphocyte HLA-B7-restricted, and B-cell neut
Clinical features and outcome in disseminated mycobacterial diseases in AIDS patients in Taiwan.: AIDS. 1998 Jul 30;12(11):1301-7. Unique Identifier : AIDSLINE MED/98372114; Hsieh SM; Hung CC; Chen MY; Hsueh PR; Chang SC; Luh KT; Department of Internal Medicine, National Taiwan University; Hospital, Taipei.; OBJECTIVE: To describe and compare the clinical features and outcome of disseminated tuberculosis (TB) and Mycobacterium avium complex (MAC) disease in AIDS patients. DESIGN: Prospective cohort study. SETTING: A 1800-bed university teaching hospital, the largest centre for HIV/AIDS patients in
Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen.: AIDS. 1998 Jul 30;12(11):1309-15. Unique Identifier : AIDSLINE MED/98372115; Burman WJ; Stone BL; Rietmeijer CA; Maslow J; Cohn DL; Reves RR; Disease Control Service and the Mycobacteriology Laboratory,; Denver Public Health, Colorado 80204, USA.; OBJECTIVES: To describe the long-term outcomes of treatment of AIDS-related Mycobacterium avium complex (MAC) bacteremia using a standard clarithromycin-based regimen. DESIGN: Retrospective study of patients with MAC bacteremia diagnosed between April 1992 and April 1995. SETTING: An urban AIDS clinic SUBJECTS: One hu
Analysis of life-long strategies to prevent Pneumocystis carinii pneumonia in patients with variable HIV progression rates.: AIDS. 1998 Jul 30;12(11):1317-25. Unique Identifier : AIDSLINE MED/98372116; Wynia MK; Ioannidis JP; Lau J; Division of Clinical Care Research, New England Medical Center; Hospitals, Boston, Massachusetts, USA.; OBJECTIVE: To compare strategies for life-long prophylaxis of Pneumocystis carinii pneumonia (PCP) in a group of AIDS patients with a wide range of disease progression rates. DESIGN: Markov decision models. METHODS: Prophylaxis strategies using high and low doses of trimethoprim-sulfamethoxazole (TS), dapsone, and/or
Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication.: AIDS. 1998 Jul 30;12(11):1327-32. Unique Identifier : AIDSLINE MED/98372117; Cinque P; Vago L; Mengozzi M; Torri V; Ceresa D; Vicenzi E; Transidico P; Vagani A; Sozzani S; Mantovani A; Lazzarin A; Poli G; Division of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.; OBJECTIVE: To investigate whether the CC-chemokine monocyte chemotactic protein (MCP)-1 could play a role in the pathogenesis of HIV infection of the central nervous system. This hypothesis was suggested by previous observations, including our finding of elevated cerebrospinal fluid (CSF) levels of this chemokine in p
Clinical experience with adding delavirdine to combination therapy in patients in whom multiple antiretroviral treatment including protease inhibitors has failed.: AIDS. 1998 Jul 30;12(11):1333-40. Unique Identifier : AIDSLINE MED/98372118; Bellman PC; St Vincent's Hospital and Medical Center, Lenox Hill Hospital,; New York, New York, USA.; OBJECTIVE: To determine the effectiveness and safety of adding delavirdine mesylate to a treatment regimen that included indinavir and nucleoside analog reverse transcriptase inhibitors in patients in whom
Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics.: AIDS. 1998 Jul 30;12(11):1341-6. Unique Identifier : AIDSLINE MED/98372119; Furrer H; Wendland T; Minder C; Christen A; von Overbeck J; Grunow R; Pichler W; Malinverni RP; AIDS Unit, Medical Policlinic, University of Berne, Switzerland.; OBJECTIVES: To study whether syncytium-inducing (SI)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients. DESIGN: Cross-sectional analysis of single centre cohort study data.
Immune markers and viral load after HIV-1 seroconversion as predictors of disease progression in a cohort of haemophilic men.: AIDS. 1998 Jul 30;12(11):1347-52. Unique Identifier : AIDSLINE MED/98372120; Sabin CA; Devereux H; Phillips AN; Janossy G; Loveday C; Lee CA; HIV Research Unit, Department of Primary Care and Population; Sciences, Royal Free Hospital and School of Medicine, London, UK.; OBJECTIVE: To assess the prognostic value of HIV RNA levels measured shortly after HIV seroconversion and whether markers of immune response (CD4+ and CD8+ T-cell counts, IgA and IgG) measured at the same time, continue to provide prognostic information once the HIV RNA level is known. DESIGN AND METHODS: HIV RNA leve
Evaluating the effect of year of seroconversion on HIV progression in cohort studies. Italian Seroconversion Study.: AIDS. 1998 Jul 30;12(11):1353-60. Unique Identifier : AIDSLINE MED/98372121; Cozzi Lepri A; Phillips AN; Pezzotti P; Mocroft A; Sabin CA; Porter K; Rezza G; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University Medical; School, University College London, UK.; OBJECTIVES: To show how a spurious association between the calendar year of seroconversion and HIV progression arises as a result of censoring the follow-up of individuals at their last visit, when the individuals visits are intermittent. DESIGN: A notional cohort of 1140 seroconverters and a cohort study of 1270 HIV
Pediatric AIDS prognosis using somatic growth velocity.: AIDS. 1998 Jul 30;12(11):1361-9. Unique Identifier : AIDSLINE MED/98372122; Carey VJ; Yong FH; Frenkel LM; McKinney RE Jr; Channing Laboratory, Harvard Medical School, Boston,; Massachusetts 02115, USA.; OBJECTIVE: To describe the natural history of somatic growth in HIV infection by constructing age-specific growth velocity norms and to assess specific prognostic information available using these norms. DESIGN: Observations on 1338 HIV-infected children aged 3 months to 15 years who participated in one of four US cli
Modelling the costs of paediatric HIV infection and AIDS: comparison of infected children born to screened and unscreened mothers.: AIDS. 1998 Jul 30;12(11):1371-80. Unique Identifier : AIDSLINE MED/98372123; Sculpher MJ; Gibb D; Ades AE; Ratcliffe J; Duong T; Health Economics Research Group, Brunel University, UK.; OBJECTIVE: To estimate the cost of managing children with HIV/AIDS in the UK from a health service perspective. DESIGN AND METHODS: Epidemiological, resource use and unit cost data were combined within a decision analytic model. A Markov model was developed to predict the prognoses of HIV-infected children under diffe
Prevention of mother-to-child transmission of HIV-1 infection: alternative strategies and their cost-effectiveness.: AIDS. 1998 Jul 30;12(11):1381-8. Unique Identifier : AIDSLINE MED/98372124; Ratcliffe J; Ades AE; Gibb D; Sculpher MJ; Briggs AH; Health Economics Research Group, Brunel University, Uxbridge, UK.; OBJECTIVE: To estimate the cost-effectiveness of alternative interventions to reduce the risk of mother-to-child transmission of HIV. DESIGN: A model capturing the sequential nature of mother-to-child transmission in utero, at delivery and postnatally was used to determine how the effects of bottle-feeding, elective C
Women's preferences regarding the formulation of over-the-counter vaginal spermicides [letter]: AIDS. 1998 Jul 30;12(11):1389-91. Unique Identifier : AIDSLINE MED/98372125; Coggins C; Elias CJ; Atisook R; Bassett MT; Ettiegnene-Traore V; Ghys PD; Jenkins-Woelk L; Thongkrajai E; VanDevanter NL
Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T-cell epitopes presented by HLA-B*2703 and B*2705 [letter]: AIDS. 1998 Jul 30;12(11):1391-3. Unique Identifier : AIDSLINE MED/98372126; Rowland-Jones S; Colbert RA; Dong T; McAdam S; Brown M; Ariyoshi K; Sabally S; Whittle H; McMichael A
Marked hypertriglyceridaemia associated with ritonavir therapy [letter]: AIDS. 1998 Jul 30;12(11):1393-4. Unique Identifier : AIDSLINE MED/98372127; Sullivan AK; Feher MD; Nelson MR; Gazzard BG
Indinavir pharmacokinetics in haemodialysis-dependent end-stage renal failure [letter]: AIDS. 1998 Jul 30;12(11):1395. Unique Identifier : AIDSLINE MED/98372128; Guardiola JM; Mangues MA; Domingo P; Martinez E; Barrio JL
Decreased prevalence of intestinal cryptosporidiosis in HIV-infected patients concomitant to the widespread use of protease inhibitors [letter]: AIDS. 1998 Jul 30;12(11):1395-7. Unique Identifier : AIDSLINE MED/98372129; Le Moing V; Bissuel F; Costagliola D; Eid Z; Chapuis F; Molina JM; Salmon-Ceron D; Brasseur P; Leport C
Two successive HIV contaminations from subjects in the window period [letter]: AIDS. 1998 Jul 30;12(11):1397-8. Unique Identifier : AIDSLINE MED/98372130; Laperche S; Moreau P; Lair J; Courouce AM
Rebound of plasma HIV viral load following prolonged suppression with combination therapy [letter]: AIDS. 1998 Jul 30;12(11):1398-9. Unique Identifier : AIDSLINE MED/98372131; Montaner JS; Harris M; Mo T; Harrigan PR
Ketoacidosis associated with protease inhibitor therapy [letter]: AIDS. 1998 Jul 30;12(11):1399-400. Unique Identifier : AIDSLINE MED/98372132; Besson C; Jubault V; Viard JP; Pialoux G
Safety profile of soft gelatin formulation of saquinavir in combination with nucleosides in a broad patient population. NV15182 Study Team [letter]: AIDS. 1998 Jul 30;12(11):1400-2. Unique Identifier : AIDSLINE MED/98372133; Gill MJ
Reply: Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients [letter]: AIDS. 1998 Jul 30;12(11):1402-3. Unique Identifier : AIDSLINE MED/98372134; Fatkenheuer G; Rockstroh J; Salzberger B
HIV seroprevalence and HIV-1 subtype E among pregnant women in Vientiane, Laos [letter]: AIDS. 1998 Jul 30;12(11):1403. Unique Identifier : AIDSLINE MED/98372135; Loue S; Bounlu K; Pholsena V; Mastro TD
Lack of correlation between V3-loop peptide enzyme immunoassay serologic subtyping and genetic sequencing.: AIDS. 1998 Aug 20;12(12):1405-12. Unique Identifier : AIDSLINE MED/98394543; Nkengasong JN; Willems B; Janssens W; Cheingsong-Popov R; Heyndrickx L; Barin F; Ondoa P; Fransen K; Goudsmit J; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; OBJECTIVE: To compare the performance of V3-loop peptide enzyme immunoassay (PEIA) methodologies from four different laboratories for subtyping HIV-1, and to determine the causes for the lack of correlation between V3-loop PEIA serotyping and subtyping by sequencing. MATERIALS AND METHODS: Synthetic peptides derived f
Structure-based design of peptides that recognize the CD4 binding domain of HIV-1 gp120.: AIDS. 1998 Aug 20;12(12):1413-8. Unique Identifier : AIDSLINE MED/98394544; Fontenot JD; Tan X; Phillips DM; Population Council, Center for Biomedical Research, New York, New; York 10021, USA.; DESIGN: Envelope protein-specific antiviral peptides, called mucibodies, that can specifically recognize and bind to the surface unit protein gp120 of HIV-1 were designed. The initial mucibody binding target was the V3 loop of HIV-1 gp120. Here, the gp120-CD4 binding domain was chosen as the site of mucibody binding.
Improved detection of HIV-2 proviral DNA in dually seroreactive individuals by PCR.: AIDS. 1998 Aug 20;12(12):1419-25. Unique Identifier : AIDSLINE MED/98394545; Ishikawa K; Fransen K; Ariyoshi K; Nkengasong JN; Janssens W; Heyndrickx L; Whittle H; Diallo MO; Ghys PD; Coulibaly IM; Greenberg AE; Piedade J; Canas-Ferreira W; van der Groen G; Institute of Tropical Medicine, Antwerp, Belgium.; OBJECTIVE: To improve the detection rate of HIV-2 proviral DNA in primary uncultured peripheral blood mononuclear cells (PBMC) of HIV-2-seroreactive and HIV-1-HIV-2 dually seroreactive individuals. MATERIALS AND METHODS: Two newly designed HIV-2 PCR primer pairs in the long terminal repeat (LTR) gag and gag-pol region
Cytotoxic T-cell responses to HIV-1 reverse transcriptase, integrase and protease.: AIDS. 1998 Aug 20;12(12):1427-36. Unique Identifier : AIDSLINE MED/98394546; Haas G; Samri A; Gomard E; Hosmalin A; Duntze J; Bouley JM; Ihlenfeldt HG; Katlama C; Autran B; Department of Molecular Biology, Max-Planck-Institut fur; Infektionsbiologie, Berlin, Germany.; OBJECTIVES: To determine immunodominant regions and new epitopes for cytotoxic T cells (CTL) directed against the HIV-1 pol products reverse transcriptase (RT), integrase and protease in a large cohort of patients at different stages of disease. DESIGN AND METHODS: Cross-sectional analysis of 98 patients from the Fren
Impairment of B-lymphocyte differentiation induced by dual triggering of the B-cell antigen receptor and CD40 in advanced HIV-1-disease.: AIDS. 1998 Aug 20;12(12):1437-49. Unique Identifier : AIDSLINE MED/98394547; Conge AM; Tarte K; Reynes J; Segondy M; Gerfaux J; Zembala M; Vendrell JP; Centre National Recherche Scientifique, Laboratoire d'Immunologie; des Infections Retrovirales, Institut de Biologie, Montpellier,; France.; OBJECTIVE: This study was performed to investigate the hyporeactivity of purified B lymphocytes from HIV-1-infected patients. DESIGN: Given the importance of the B-cell Ag receptor (BCR) and CD40 in B-lymphocyte activation, we assessed the capacity of purified peripheral blood B lymphocytes from HIV-1-infected patient
Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease.: AIDS. 1998 Aug 20;12(12):1451-7. Unique Identifier : AIDSLINE MED/98394548; Sterling TR; Moore RD; Graham NM; Astemborski J; Vlahov D; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; OBJECTIVE: To determine the relationship between Mycobacterium tuberculosis infection and disease and subsequent disseminated M. avium complex (MAC) disease in HIV-infected persons. DESIGN: A prospective observational cohort study. SETTING: The AIDS Linked to the Intravenous Experience (ALIVE) cohort of injecting drug
Early regression of cervical lesions in HIV-seropositive women receiving highly active antiretroviral therapy.: AIDS. 1998 Aug 20;12(12):1459-64. Unique Identifier : AIDSLINE MED/98394549; Heard I; Schmitz V; Costagliola D; Orth G; Kazatchkine MD; INSERM U 430 and Universite Pierre et Marie Curie, Hopital; Broussais, Paris, France.; OBJECTIVE: Advanced HIV disease is associated with a high prevalence of cervical squamous intra-epithelial lesions (SIL) and of infection with oncogenic human papillomavirus (HPV) genotypes. Triple-combination antiretroviral therapy results in decreased plasma HIV viral load, increased CD4 cell counts and partial rest
Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy.: AIDS. 1998 Aug 20;12(12):1465-74. Unique Identifier : AIDSLINE MED/98394550; Race E; Gilbert SM; Sheldon JG; Rose JS; Moffatt AR; Sitbon G; Dissanayeke SR; Cammack N; Duncan IB; Department of Virology, Roche Discovery Welwyn, Welwyn Garden; City, Hertfordshire, UK.; OBJECTIVES: Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine ( ddC ), to determine the influence of such changes on viral phenotype and response to treatment. D
Kaposi's sarcoma in HIV infection: impact on opportunistic infections and survival.: AIDS. 1998 Aug 20;12(12):1475-81. Unique Identifier : AIDSLINE MED/98394551; Brodt HR; Kamps BS; Helm EB; Schofer H; Mitrou P; Medizinische Klinik III/Infektiologie, Frankfurt, Germany.; OBJECTIVE: To determine the effect of Kaposi s sarcoma on survival of HIV-infected patients. METHODS: Retrospective cohort study to compare the survival of 241 HIV-infected homosexual patients with Kaposi s sarcoma (cases) with that of 241 HIV-infected homosexual patients without Kaposi s sarcoma (control subjects) bu
Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen.: AIDS. 1998 Aug 20;12(12):1483-90. Unique Identifier : AIDSLINE MED/98394552; Notermans DW; Goudsmit J; Danner SA; de Wolf F; Perelson AS; Mittler J; Department of Human Retrovirology, University of Amsterdam, The; Netherlands.; OBJECTIVES AND DESIGN: The dynamics uf viral decline following the initiation of antiretroviral treatment were studied in 29 HIV-1-infected patients participating in a two-arm trial comparing immediate (group A: ritonavir , zidovudine and lamivudine) a
HIV combination therapy: partial immune restitution unmasking latent cryptococcal infection.: AIDS. 1998 Aug 20;12(12):1491-4. Unique Identifier : AIDSLINE MED/98394553; Woods ML 2nd; MacGinley R; Eisen DP; Allworth AM; Infectious Diseases Unit, Wattlebrae, Royal Brisbane Hospital,; Herston, Queensland, Australia.; OBJECTIVE: To describe two cases of cryptococcal meningitis and one re-exacerbation of Cryptococcus-associated meningitis occurring in temporal association with commencement of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection (CD4 cells
A randomized trial of the effect of ritonavir in maintaining quality of life in advanced HIV disease. Advanced HIV Disease Ritonavir Study Group.: AIDS. 1998 Aug 20;12(12):1495-502. Unique Identifier : AIDSLINE MED/98394554; Cohen C; Revicki DA; Nabulsi A; Sarocco PW; Jiang P; Community Research Initiative of New England, Brookline,; Massachusetts, USA.; BACKGROUND: The aim of treatment for HIV disease is prolonging survival and improvement in health-related quality of life. Ritonavir is a potent, orally bioavailable HIV protease inhibitor with demonstrated impact on surrogate endpoints, AIDS-defining
Preventing Mycobacterium avium complex in patients who are using protease inhibitors: a cost-effectiveness analysis.: AIDS. 1998 Aug 20;12(12):1503-12. Unique Identifier : AIDSLINE MED/98394555; Bayoumi AM; Redelmeier DA; Department of Medicine, University of Toronto, Canada.; BACKGROUND: Practice guidelines recommending Mycobacterium avium complex (MAC) prophylaxis for patients with HIV disease were based on clinical trials in which individuals did not receive protease inhibitors . OBJECTIVE: To estimate the cost-effectiveness of strategi
An open randomized controlled trial of zidovudine plus lamivudine versus stavudine plus lamivudine.: AIDS. 1998 Aug 20;12(12):1513-9. Unique Identifier : AIDSLINE MED/98394556; Foudraine NA; de Jong JJ; Jan Weverling G; van Benthem BH; Maas J; Keet IP; Jurriaans S; Roos MT; Vandermeulen K; de Wolf F; Lange JM; Department of Public Health and Environment, Academic Medical; Centre, University of Amsterdam, The Netherlands.; OBJECTIVE: To compare the antiretroviral effect and safety of zidovudine (ZDV)-lamivudine ( 3TC ) with that of stavudine (
Effect of HIV-specific immune-based therapy in subjects infected with HIV-1 subtype E in Thailand.: AIDS. 1998 Aug 20;12(12):1521-7. Unique Identifier : AIDSLINE MED/98394557; Churdboonchart V; Moss RB; Sirawaraporn W; Smutharaks B; Sutthent R; Jensen FC; Vacharak P; Grimes J; Theofan G; Carlo DJ; Mahidol University, Phayathai, Bangkok, Thailand.; OBJECTIVE: To examine the effect of treatment with an inactivated, gp120-depleted, HIV-1 immunogen (Remune) in 30 Thai subjects infected with HIV-1 subtype E. DESIGN: Sixty-week open-label study. METHODS: Thirty HIV-positive volunteers with CD4 cell counts > or = 300 x 10(6)/l were given intramuscular injections of Re
Social network dynamics and HIV transmission.: AIDS. 1998 Aug 20;12(12):1529-36. Unique Identifier : AIDSLINE MED/98394558; Rothenberg RB; Potterat JJ; Woodhouse DE; Muth SQ; Darrow WW; Klovdahl AS; Department of Family and Preventive Medicine, Emory University; School of Medicine, Atlanta, GA 30303-3219, USA.; OBJECTIVE: To prospectively study changes in the social networks of persons at presumably high risk for HIV in a community with low prevalence and little endogenous transmission. METHODS: From a cohort of 595 persons at high risk (prostitutes, injecting drug users, and sexual partners of these persons) and nearly 6000
The incubation period to AIDS in injecting drug users estimated from prevalent cohort data, accounting for death prior to an AIDS diagnosis.: AIDS. 1998 Aug 20;12(12):1537-44. Unique Identifier : AIDSLINE MED/98394559; Hendriks JC; Satten GA; van Ameijden EJ; van Druten HA; Coutinho RA; van Griensven GJ; Department of Public Health, Municipal Health Service, Amsterdam,; The Netherlands.; OBJECTIVE: To estimate the incubation-period distribution (time from seroconversion to AIDS) accounting for death before an AIDS diagnosis (DBAD) in a cohort of injecting drug users (IDU) in Amsterdam, The Netherlands and to compare these estimates with those previously obtain
Sensitivity and specificity of a qualitative RNA detection assay to diagnose HIV infection in young infants. Perinatal AIDS Collaborative Transmission Study.: AIDS. 1998 Aug 20;12(12):1545-9. Unique Identifier : AIDSLINE MED/98394560; Simonds RJ; Brown TM; Thea DM; Orloff SL; Steketee RW; Lee FK; Palumbo PE; Kalish ML; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To evaluate the sensitivity and specificity of an RNA detection assay for diagnosing perinatal HIV infection. METHODS: Plasma and serum specimens taken during the first 3 months of life from HIV-infected and uninfected children enrolled in a cohort study were assayed for HIV RNA using the qualitative nuclei
Taenia crassiceps cysticercosis and AIDS [letter]: AIDS. 1998 Aug 20;12(12):1551-2. Unique Identifier : AIDSLINE MED/98394561; Maillard H; Marionneau J; Prophette B; Boyer E; Celerier P
Combination antiretroviral therapy for HIV infection: policies and practices [letter]: AIDS. 1998 Aug 20;12(12):1552-3. Unique Identifier : AIDSLINE MED/98394562; Lansky A; Ward JW; Jones JL
Serum antibodies to dietary antigens in patients with HIV-1 infection [letter]: AIDS. 1998 Aug 20;12(12):1553-5. Unique Identifier : AIDSLINE MED/98394563; Wahnschaffe U; Zippel T; Schmidt W; Schneider T; Schulzke JD; Riecken EO; Ullrich R
Once weekly azithromycin as prophylaxis against recurrence of non-tuberculous mycobacterial infections in HIV-1-positive individuals [letter]: AIDS. 1998 Aug 20;12(12):1555-7. Unique Identifier : AIDSLINE MED/98394564; Moyle GJ; Gill J; Nelson M
Decline of anti-DP107 antibody associated with clinical progression [letter]: AIDS. 1998 Aug 20;12(12):1557-9. Unique Identifier : AIDSLINE MED/98394565; Hattori T; Komoda H; Pahwa S; Tateyama M; Zhang X; Xu Y; Oguma S; Tamamura H; Fujii N; Fukutake K; Uchiyama T
Partner notification in newly diagnosed HIV-positive patients [letter]: AIDS. 1998 Aug 20;12(12):1559-60. Unique Identifier : AIDSLINE MED/98394566; Elliott SA; Ahmad S; Ross JD
Who may be engaging in high-risk sex due to medical treatment advances? [letter]: AIDS. 1998 Aug 20;12(12):1560-1. Unique Identifier : AIDSLINE MED/98394567; Remien RH; Wagner G; Carballo-Dieguez A; Dolezal C
Four novel cytotoxic T-lymphocyte epitopes in the highly conserved major homology region of HIV-1 Gag, restricted through B*4402, B*1801, A*2601, B*70 (B*1509) [letter]: AIDS. 1998 Aug 20;12(12):1561-3. Unique Identifier : AIDSLINE MED/98394568; Ogg GS; Dong T; Hansasuta P; Dorrell L; Clarke J; Coker R; Luzzi G; Conlon C; McMichael AP; Rowland-Jones S
HIV-1 subtypes in Santiago, Chile [letter]: AIDS. 1998 Aug 20;12(12):1563-5. Unique Identifier : AIDSLINE MED/98394569; Desgranges C; Fillon S; Letourneur F; Buzelay L; Sepulveda C; Guzman MA; Afani A; Barin F; Saragosti S
HIV-1 group O virus infection in Abidjan, Cote d'Ivoire [letter]: AIDS. 1998 Aug 20;12(12):1565-6. Unique Identifier : AIDSLINE MED/98394570; Nkengasong J; Sylla-Koko F; Peeters M; Ellenberger D; Sassan-Morokro M; Ekpini RA; Msellati P; Greenberg AE; Combe P; Rayfield M
Distribution of pyranocoumarins in Calophyllum cordato-oblongum.: Phytochemistry. 1998 Oct;49(4):995-8. Unique Identifier : AIDSLINE MED/99004414; Dharmaratne HR; Mayuri Sajeevani JR; Marasinghe GP; Shantha Ekanayake EM; Natural Products Programme, Institute of Fundamental Studies,; Kandy, Sri Lanka.; Twigs of Calophyllum cordato-oblongum have been shown to contain a new pyranocoumarin, the methyl ether of cordatolide B, three reported pyranocoumarins, cordato-oblongic acid, friedelin, canophyllol and taraxerol. Buds of this species contained large quantities of pyranocoumarins and a small amount of sitosterol. Thi
Effects of beta2 adrenoceptor agonists on T-cell subpopulations.: APMIS. 1998 Sep;106(9):849-57. Unique Identifier : AIDSLINE MED/99023597; Holen E; Elsayed S; Allergy Research Group, Department of Clinical Biochemistry,; University Hospital, Bergen, Norway.; The aim of the present communication is to determine the effects of beta2 adrenoceptor agonists on growth and cytokine secretion using allergen-specific T cells. Four beta2 adrenoceptor agonists were administered at therapeutically relevant doses (salbutamol 1-2 microM; salmeterol 0.03-0.06 microM; terbutaline 0.56-1.
Sticky-end PCR: new method for subcloning.: Biotechniques. 1998 Aug;25(2):206-8. Unique Identifier : AIDSLINE MED/98380586; Zeng G; Georgetown University Medical Center Washington, DC, USA.
Fission yeast expression vectors adapted for positive identification of gene insertion and green fluorescent protein fusion.: Biotechniques. 1998 Sep;25(3):438-40, 442, 444. Unique Identifier : AIDSLINE GENBANK/AF064067; Zhao Y; Elder RT; Chen M; Cao J; Children's Memorial Institute of Education and Research, Chicago,; IL 60614, USA.; A pYZ series of fission yeast expression vectors, derivatives of the pREP series, was designed to allow positive identification of cloned gene insertion and fusion to the green fluorescent protein (GFP) gene for in vivo analysis of gene expression. To validate this new vector system, the human immunodeficiency virus t
Quantitation of mixed-base populations of HIV-1 variants by automated DNA sequencing with BODIPY dye-labeled primers.: Biotechniques. 1998 Sep;25(3):446-7, 450-2, 454, passim. Unique Identifier : AIDSLINE MED/98435191; Metzker ML; Ansari-Lari MA; Liu XM; Holder DJ; Gibbs RA; Baylor College of Medicine, Houston, TX, USA.; Direct DNA sequencing of human immunodeficiency virus type 1 (HIV-1) pol and env gene regions was characterized for accuracy and precision. Restricted maximum likelihood (REML) analysis of molecular clone reconstruction experiments using a primer-walking strategy showed that the BODIPY and BODIPY energy-transfer (BET)
Mutation typing using electrophoresis and gel-immobilized Acrydite probes.: Biotechniques. 1998 Sep;25(3):516-21. Unique Identifier : AIDSLINE MED/98435197; Kenney M; Ray S; Boles TC; Mosaic Technologies, Inc., Boston, MA, USA.; A new electrophoresis technology for hybridization-based sequence detection and mutation typing is described. Intrinsic to this approach is copolymerization of specially modified oligonucleotide probes directly into polyacrylamide gels. Electrophoresis of single-stranded samples through gels containing specific immobi
A protocol-contract for opioid use in patients with chronic pain not due to malignancy.: J Clin Anesth. 1998 Aug;10(5):435-43. Unique Identifier : AIDSLINE MED/98368010; Kirkpatrick AF; Derasari M; Kovacs PL; Lamb BD; Miller R; Reading A; Department of Anesthesiology, University of South Florida College; of Medicine, Tampa 33612-4799, USA.; The legal, psychosocial, and medical factors that we believe have contributed to the success of our protocol-contract in prescribing opioids to patients with chronic pain not due to malignancy are outlined. These factors may be applicable to the treatment of a variety of chronic nonmalignant pain syndromes such as pos
Development and testing of an HIV-risk screening instrument for use in health care settings.: Am J Prev Med. 1998 Aug;15(2):103-13. Unique Identifier : AIDSLINE MED/98379287; Gerbert B; Bronstone A; McPhee S; Pantilat S; Allerton M; Division of Behavioral Sciences, School of Dentistry, University; of California, San Francisco 94111, USA.; OBJECTIVE: To develop and test a brief, reliable, and valid HIV-risk screening instrument for use in primary health care settings. DESIGN: A two-phase study: (1) developing a self-administered HIV-risk screening instrument, and (2) testing it with a primary care population, including testing the effect of confidential
Comparison of simulated patient and didactic methods of teaching HIV risk assessment to medical residents.: Am J Prev Med. 1998 Aug;15(2):114-9. Unique Identifier : AIDSLINE MED/98379288; Madan AK; Caruso BA; Lopes JE; Gracely EJ; Department of Surgery, Tulane University Medical Center, New; Orleans, Louisiana 70112, USA.; INTRODUCTION: Physicians need to be well trained in HIV risk assessment interview skills. Little has been written in the literature concerning training methods for this specialized interview. METHODS: One model to teach the HIV risk assessment interview has been developed and has been used to teach third-year medical
Post-exposure prophylaxis for HIV infection in gay and bisexual men. Implications for the future of HIV prevention.: Am J Prev Med. 1998 Aug;15(2):120-7. Unique Identifier : AIDSLINE MED/98379289; Kalichman SC; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA.; OBJECTIVE: To assess the psychological and behavioral characteristics of gay and bisexual men who intend to use antiretroviral post-exposure prophylaxis (PEP) to prevent HIV infection. METHODS: Gay and bisexual men who had not tested HIV seropositive and were not in long-term exclusive sexual relationships (n = 327) c
Fine specificity of anti-V3 antibodies induced in chimpanzees by HIV candidate vaccines.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1023-34. Unique Identifier : AIDSLINE MED/98382243; Coeffier E; Girard M; Barre-Sinoussi F; Meignier B; Muchmore E; Fultz PN; LeClerc C; Unite de Biologie des Regulations Immunitaires, Institut; Pasteur, Paris, France. coeffier@pasteur.fr; The fine specificity of the anti-V3 antibody responses induced in chimpanzees immunized by various human immunodeficiency type 1 (HIV-1) candidate vaccines and challenged by heterologous strains of HIV-1 was analyzed by enzyme-linked immunosorbent assay (ELISA) and Pepscan epitope mapping. Two chimpanzees immunized wi
Neutralizing antibodies administered before, but not after, virulent SHIV prevent infection in macaques.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1035-43. Unique Identifier : AIDSLINE MED/98382244; Foresman L; Jia F; Li Z; Wang C; Stephens EB; Sahni M; Narayan O; Joag SV; Department of Microbiology, University of Kansas Medical Center,; Kansas City 66160-7424, USA.; By subcutaneous inoculation of SHIV(KU-2) in the hands of macaques, we developed a model of human immunodeficiency virus type-1 (HIV-1) occupational infection due to needle-stick injury and used the model to determine whether neutralizing serum to SHIV administered before or after virus inoculation could either preven
Failure of SIVmac to be neutralized in macrophage cultures is unique to SIVmac and not observed with neutralization of SHIV or HIV-1.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1045-51. Unique Identifier : AIDSLINE MED/98382245; Zhuge W; Jia F; Stephens EB; Li Z; Wang C; Joag SV; Narayan O; Department of Microbiology, Molecular Genetics and Immunology,; University of Kansas Medical Center, Kansas City 66160-7424, USA.; wzhuge@kumc.edu; Except during acutely lethal infection, macaques infected with SIVmac251 produce antibodies that neutralize the virus in CEMx174 cells, macaque PBMC and macrophage cultures. In a previous report, we had shown that whereas neutralization of the SIVmac251 was complete in lymphocyte cultures, protected macrophages had
Cellular proviral HIV type 1 DNA load persists after long-term RT-inhibitor therapy in HIV type 1 infected persons.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1053-8. Unique Identifier : AIDSLINE MED/98382246; Bruisten SM; Reiss P; Loeliger AE; van Swieten P; Schuurman R; Boucher CA; Weverling GJ; Huisman JG; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Department of Clinical Viro-Immunology, Amsterdam.; In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine ( AZT ) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanos
Impaired fitness of foscarnet-resistant strains of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1059-64. Unique Identifier : AIDSLINE MED/98382247; Tachedjian G; Mellors JW; Bazmi H; Mills J; National Centre in HIV Virology Research, Macfarlane Burnet; Centre for Medical Research, Fairfield, Australia.; Foscarnet (PFA) is a pyrophosphate analogue antiviral active against human immunodeficiency virus (HIV-1) and herpesviruses. Strains of HIV-1 resistant to PFA have mutations in the HIV-1 reverse transcriptase (RT). We examined the influence of PFA resistance mutations, in different genetic backgrounds, on HIV-1 replic
Increased cerebrospinal fluid ganglioside GD3 concentrations as a marker of microglial activation in HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1065-9. Unique Identifier : AIDSLINE MED/98382248; Andersson LM; Fredman P; Lekman A; Rosengren L; Gisslen M; Department of Infectious Diseases, Institute of Clinical; Neuroscience, Goteborg University, Sweden.; Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the infectious course. The predominant, productively infected cell type within the CNS is the microglial cell. We have analyzed the cerebrospinal fluid (CSF) levels of the ganglioside GD3, a microglia/macrophage and astrocyte
Cardiac involvement in the acquired immunodeficiency syndrome: a multicenter clinical-pathological study. Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS Investigators.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1071-7. Unique Identifier : AIDSLINE MED/98382249; Barbaro G; Di Lorenzo G; Grisorio B; Barbarini G; Department of Emergency Medicine University La Sapienza, Rome,; Italy.; The heart is frequently involved in the acquired immunodeficiency syndrome (AIDS). This study was planned to assess the prevalence of cardiac involvement in a large and selected population of patients who died of AIDS. Of 440 AIDS patients who underwent autopsy, cardiac involvement was documented in 82 patients. Dilat
Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1079-85. Unique Identifier : AIDSLINE MED/98382250; Novitsky VA; Montano MA; Essex M; Harvard AIDS Institute, Department of Immunology and Infectious; Diseases, Harvard School of Public Health, Boston, Massachusetts; 02115, USA.; Phylogenetic characterization of primary isolates from 17 HIV-1-infected individuals within a recent epidemic in the city of Odessa, Ukraine was conducted. The isolates were drawn from two time periods, 1993 and 1996. The 1996 isolates coincided with the first apparent expansion o
Feline immunodeficiency virus is shed in semen from experimentally and naturally infected cats.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1087-92. Unique Identifier : AIDSLINE MED/98382251; Jordan HL; Howard J; Barr MC; Kennedy-Stoskopf S; Levy JK; Tompkins WA; Harvard Medical School, Division of Viral Pathogenesis, Beth; Israel Deaconess Medical Center, Boston, Massachusetts 02215,; USA.; Although a laboratory isolate of feline immunodeficiency virus (FIV), FIV-NCSU1, has been transmitted by artificial insemination in domestic cats, transmission by naturally infected males during mating has not been reported. In order to determine whether virus shedding in semen is unique to the NCSU1 isolate, we analy
Identification of novel human endogenous retroviral sequences belonging to the HERV-K family.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1093-8. Unique Identifier : AIDSLINE MED/98382252; Zsiros J; Jebbink MF; Voute PA; Berkhout B; Department of Pediatric Oncology, Academic Medical Center,; University of Amsterdam, The Netherlands.
HIV type 1 subtypes of nonhemophiliac patients in Japan.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1099-103. Unique Identifier : AIDSLINE MED/98382253; Kitsutani PT; Naganawa S; Shiino T; Matsuda M; Honda M; Yamada K; Taki M; Sugiura W; National Institute of Infectious Diseases, AIDS Research Center,; Tokyo, Japan.
Human immunodeficiency virus type 1 subtypes B and C detected in New Zealand.: AIDS Res Hum Retroviruses. 1998 Aug 10;14(12):1105-8. Unique Identifier : AIDSLINE MED/98382254; Dwyer DE; Herring BL; Ge YC; Bolton WV; Ellis-Pegler RB; Thomas M; Schroeder BA; Croxson MC; Cunningham AL; Mullins JI; Saksena NK; Centre for Virus Research, Westmead Institutes of Health; Research, ICPMR, Westmead Hospital, Australia.; dominicd@westmed.wh.usyd.edu.au
HIV and AIDS information on the Internet.: J Am Acad Nurse Pract. 1998 Apr;10(4):173-4. Unique Identifier : AIDSLINE MED/99018359; Korn K; Student Health Service, University of South Dakota, Vermillion,; USA.
[Idiopathic CD4+ lymphocytopenia: a clinico-immunological syndrome of uncertain significance (editorial; comment)]: Ann Ital Med Int. 1997 Oct-Dec;12(4):197-8. Unique Identifier : AIDSLINE MED/98446749; Dammacco F
Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers.: Br J Clin Pharmacol. 1998 Aug;46(2):111-6. Unique Identifier : AIDSLINE MED/98389211; Ouellet D; Hsu A; Qian J; Locke CS; Eason CJ; Cavanaugh JH; Leonard JM; Granneman GR; Abbott Laboratories, Abbott Park, IL 60064-3500, USA.; AIMS: To assess the effects of the protease inhibitor ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers. METHODS: This was an open-label, single centre study in 23 subjects who received two single doses of oral contr
Costs and cost-effectiveness of new technologies in cancer.: Cancer Treat Res. 1998;97:25-36. Unique Identifier : AIDSLINE MED/98377266; Waters TM; Institute for Health Services Research & Policy Studies,; Northwestern University, Evanston, IL 60208, USA.
Infectious arthritis and immune dysfunction.: Curr Opin Rheumatol. 1998 Jul;10(4):B139-46. Unique Identifier : AIDSLINE MED/98392726
Bacterial arthritis.: Curr Opin Rheumatol. 1998 Jul;10(4):330-4. Unique Identifier : AIDSLINE MED/98392715; Ike RW; Rheumatology Division, University of Michigan Medical Center, Ann; Arbor 48109-0358, USA.; Reports pertinent to bacterial arthritis in 1997 included two large, multi-year surveys of joint infection in patients from defined European health districts, noting trends including the declining incidence of gonococcal arthritis and an increasing number of prosthetic joint infections. Children with infected joints g
Retrovirus-associated rheumatic syndromes.: Curr Opin Rheumatol. 1998 Jul;10(4):347-54. Unique Identifier : AIDSLINE MED/98392718; Herrmann M; Neidhart M; Gay S; Hagenhofer M; Kalden JR; Friedrich-Alexander University of Erlangen-Nuremberg, Department; of Internal Medicine III, Germany.; The influence of environmental factors in the initiation of autoimmune rheumatic diseases is still under debate. Infections with viruses (e.g., retroviruses) or expression of gene products encoded by endogenous retroviruses are believed to contribute to both loss of tolerance for autoantigens and immunosuppression. In
Recommendations on the safe and effective use of short-course ZDV for prevention of mother-to-child transmission of HIV.: Wkly Epidemiol Rec. 1998 Oct 9;73(41):313-20. Unique Identifier : AIDSLINE MED/99011670
In it together.: Nurs Stand. 1998 Aug 12-18;12(47):18. Unique Identifier : AIDSLINE MED/98424703; Pinching A; Medical College of St Bartholomew's Hospital.
Low CD4 counts rather than superantigenic-like effects account for differences in expressed T-cell receptor (TCR) repertoires between HIV-1 seropositive long-term non-progressors and individuals with progressive disease.: Br J Haematol. 1998 Sep;102(5):1187-96. Unique Identifier : AIDSLINE MED/98423966; Westby M; Vaughan AN; Balotta C; Galli M; Clerici M; Dalgleish AG; Division of Oncology, Cellular and Molecular Sciences, St; George's Hospital Medical School, London, UK.; Analysis of HIV-infected individuals who have stable CD4 counts many years after seroconversion may provide an insight as to how the host s immune system can successfully control HIV infection. In this study we analysed the T-cell receptor (TCR) Vbeta repertoire in 13 HIV+ individuals, seven of whom were classed as lo
Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles.: Br J Haematol. 1998 Sep;102(5):1314-22. Unique Identifier : AIDSLINE MED/98423984; Molldrem JJ; Jiang YZ; Stetler-Stevenson M; Mavroudis D; Hensel N; Barrett AJ; Department of Blood and Marrow Transplantation, University of; Texas M. D. Anderson Cancer Center, Houston 77030, USA.; We have demonstrated that 44% of myelodysplastic syndrome (MDS) patients with cytopenia have a haematological response to antithymocyte globulin (ATG). Three ATG responders and two non-responders with refractory anaemia were further studied for lymphocyte-mediated inhibition of bone marrow using a standard CFU-GM assa
Dendritic cells derived from bone marrow and CD34+ selected blood progenitor cells of myeloma patients, cultured in serum-free media, do not contain the Kaposi sarcoma herpesvirus genome.: Br J Haematol. 1998 Sep;102(5):1338-40. Unique Identifier : AIDSLINE MED/98423989; Mitterer M; Mair W; Gatti D; Sheldon J; Vachula M; Coser P; Schultz TF; Department of Haematology and Bone Marrow Transplantation Centre,; Bozen/Bolzano, Italy.; The aim of our study was to test if dendritic cells contain the KSHV genome. CD34+ peripheral blood progenitor cells (PBPC) and bone marrow mononuclear cells were cultured in X-VIVO 15 medium supplemented with GM-CSF and TNF-alpha in gas-permeable containers. Dendritic cells were identified morphologically and immunop
Development of autoantibodies and factor VIII inhibitor in an HIV-infected haemophiliac following treatment with combination anti-retroviral therapy [letter]: Br J Haematol. 1998 Sep;102(5):1382-3. Unique Identifier : AIDSLINE MED/98423999; Evans GD; Mendelson GM; Lever AM; Baglin TP
Two cases of cerebral aneurysms in HIV+ children.: Pediatr Neurosurg. 1998 Jan;28(1):31-4. Unique Identifier : AIDSLINE MED/98376112; Fulmer BB; Dillard SC; Musulman EM; Palmer CA; Oakes J; Division of Neurosurgery, University of Alabama at Birmingham,; USA.; Two cases of fusiform cerebral aneurysms in human immunodeficiency virus (HIV) positive children are presented. To our knowledge, only 9 patients with this association have been reported. One of our patients represents the first report of a patient with an aneurysm associated with varicella-zoster vasculitis. One pati
The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin.: Ann Oncol. 1998 Jul;9(7):711-6. Unique Identifier : AIDSLINE MED/98411752; Berry G; Billingham M; Alderman E; Richardson P; Torti F; Lum B; Patek A; Martin FJ; Department of Surgical Pathology, Stanford University, CA, USA.; BACKGROUND: Pegylated liposomal doxorubicin (PL-DOX) has been shown in preclinical models to induce less cardiotoxicity than non-liposomal doxorubicin. Endomyocardial biopsy is a highly sensitive and specific method for detecting anthracycline-induced cardiac damage. PATIENTS AND METHODS: Myocardial tissue from ten KS
Increased frequency of CD8 positive gamma/delta T-lymphocytes (CD8+ gamma/delta+) in unmedicated schizophrenic patients: relation to impairment of the blood-brain barrier and HLA-DPA*02011 [letter]: Schizophr Res. 1998 Jun 22;32(1):69-71. Unique Identifier : AIDSLINE MED/98354794; Muller N; Schlesinger BC; Hadjamu M; Riedel M; Schwarz M; Ackenheil M; Wank R; Gruber R
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4.: Int Immunol. 1998 Aug;10(8):1017-26. Unique Identifier : AIDSLINE MED/98389080; Liu L; Rich BE; Inobe J; Chen W; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, MA 02115, USA.; A number of observations indicate that exposure to IL-4 is essential for the priming of Th2-type effector T cells and that exposure to IL-12 is essential for the priming of Th1-type effector T cells. However, the initial source of IL-4 in the early immune response has not been clearly identified. Dendritic cells (DC)
Analysis of the TCR Vgamma repertoire in healthy donors and HIV-1-infected individuals.: Int Immunol. 1998 Aug;10(8):1067-75. Unique Identifier : AIDSLINE MED/98389085; Wesch D; Hinz T; Kabelitz D; Department of Immunology, Paul-Ehrlich-Institute, Langen,; Germany.; During the course of infection with HIV-1, striking alterations in the subset distribution of peripheral blood gammadelta T cells are observed. While TCR Vdelta2 expression dominates among peripheral blood gammadelta T cells in healthy adults, there is a clear preponderance of Vdelta1 cells in HIV-1-infected persons.
Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process.: Int Immunol. 1998 Aug;10(8):1203-10. Unique Identifier : AIDSLINE MED/98389100; Kametani Y; Goto H; Kobori A; Sato T; Ando K; Hozumi K; Nishimura T; Saito T; Yamamoto T; Habu S; Department of Immunology, Tokai University School of Medicine,; Kanagawa, Japan.; Antigen stimulation via TCR in mature T cells provides rapid induction of tyrosine phosphorylation of intracellular substrates including ZAP-70. To study the potential involvement of tyrosine phosphorylation in CD4+CD8+ [double-positive (DP)] thymocytes in the positive selection process in vivo, we isolated and analyz
The effect of pregnancy on survival in women infected with HIV: a systematic review of the literature and meta-analysis.: Br J Obstet Gynaecol. 1998 Aug;105(8):827-35. Unique Identifier : AIDSLINE MED/98417456; French R; Brocklehurst P; Department of Sexually Transmitted Diseases, The Mortimer Market; Centre, London, UK.; OBJECTIVE: To investigate the effect of pregnancy on disease progression and survival in women infected with HIV by a systematic review of the literature and meta-analysis. METHODS: Appropriate publications were identified using electronic and hand searching of relevant journals from 1983 to 1996. Studies were include
The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis.: Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. Unique Identifier : AIDSLINE MED/98417457; Brocklehurst P; French R; National Perinatal Epidemiology Unit, Radcliffe Infirmary,; Oxford, UK.; OBJECTIVE: To investigate the association between maternal HIV infection and perinatal outcome by a systematic review of the literature and meta-analysis. METHODS: Appropriate publications were identified using electronic and hand searching of relevant journals from 1983 to 1996. Studies were included in the review if
Women's knowledge and attitudes, and the acceptability of voluntary antenatal HIV testing.: Br J Obstet Gynaecol. 1998 Aug;105(8):849-54. Unique Identifier : AIDSLINE MED/98417458; Duffy TA; Wolfe CD; Varden C; Kennedy J; Chrystie IL; Women's Services, Guy's and St Thomas' Hospitals Trust, London,; UK.; OBJECTIVE: To assess pregnant women s knowledge of, and attitudes towards, antenatal HIV testing, and its acceptability to them. SETTING: Antenatal clinic at Guy s Hospital, London, six community antenatal clinics and a midwifery group practice. POPULATION: Eight hundred and forty-three women attending the antenatal c
The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability.: Biochemistry. 1998 Sep 29;37(39):13710-9. Unique Identifier : AIDSLINE MED/98426068; Gonzalez ME; Carrasco L; Centro de Biologia Molecular CSIC-UAM, Universidad Autonoma de; Madrid, Cantoblanco, Spain. megonzalez@cbm.uam.es; Infection of T lymphocytes by the human immunodeficiency virus causes drastic alterations in the intracellular cation content of the infected cells. The human immunodeficiency virus type 1 genome encodes several accessory proteins, including Vpu, an integral membrane protein that forms ion channels in planar lipid bil
Effects of secondary structure on DNA and RNA cleavage by diplatinum(II).: Biochemistry. 1998 Sep 29;37(39):13736-43. Unique Identifier : AIDSLINE MED/98426071; Carter PJ; Breiner KM; Thorp HH; Department of Chemistry, University of North Carolina, Chapel; Hill 27599-3290, USA.; The photochemistry of Pt2(pop)44- with nucleic acids has been studied using radiolabeled oligomers of DNA and RNA and high-resolution electrophoresis (pop is P2O5H22-). Photolysis of Pt2(pop)44- with duplex DNA produces an even cleavage ladder and relatively little enhancement of cleavage upon treatment with piperidin
Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR).: Biochemistry. 1998 Sep 29;37(39):13816-26. Unique Identifier : AIDSLINE MED/98426080; Wu S; Kumar KU; Kaufman RJ; The Howard Hughes Medical Institute, Department of Biological; Chemistry, University of Michigan Medical Center, Ann Arbor; 48109, USA.; The interferon-inducible, double-stranded (ds) RNA-dependent protein kinase (PKR) regulates protein synthesis initiation by phosphorylating the alpha-subunit of eukaryotic translation initiation factor 2 (eIF-2). The amino-terminal half of PKR contains two dsRNA binding domains, and the kinase domain resides in the ca
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.: Biochemistry. 1998 Sep 29;37(39):13835-45. Unique Identifier : AIDSLINE MED/98426082; Ridky TW; Kikonyogo A; Leis J; Gulnik S; Copeland T; Erickson J; Wlodawer A; Kurinov I; Harrison RW; Weber IT; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; A series of mutations, first identified in protease inhibitor-resistant HIV-1 viral isolates, were introduced into HIV-1 PR as individual substitutions. Mutants containing R8K, V32I, V82T, I84V, G48V/L90M, or V82T/I84V substitutions were analyzed for differences in substrate preference and catalytic efficiency using a
The dimerization domain of potato spindle tuber viroid, a possible hallmark for infectious RNA.: Biochemistry. 1998 Oct 6;37(40):14098-107. Unique Identifier : AIDSLINE MED/98434382; Gast FU; Kempe D; Sanger HL; Institut fur Biochemie, Justus-Liebig-Universitat Giessen,; Germany. Frank-Ulrich.Gast@chemie.bio.uni-giessen.de; Covalently closed circular (+) RNA of the potato spindle tuber viroid (PSTVd) can efficiently dimerize noncovalently upon heating and slow cooling in the presence of monovalent cations or Mg2+. In vitro transcription of subgenomic fragments reveals that the ability to dimerize resides in the upper strand of its self
Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance.: Biochemistry. 1998 Oct 6;37(40):14189-94. Unique Identifier : AIDSLINE MED/98434393; Vaccaro JA; Anderson KS; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06520-8066, USA.; There is a lack of correlation between biochemical studies and the observed clinical resistance of AIDS patients on long-term AZT therapy. Mutant HIV-1 reverse transcriptase in the viral isolates from these patients shows a 100-fold decrease in sensit
Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules.: Biochemistry. 1998 Oct 6;37(40):14204-12. Unique Identifier : AIDSLINE MED/98434395; Mei HY; Cui M; Heldsinger A; Lemrow SM; Loo JA; Sannes-Lowery KA; Sharmeen L; Czarnik AW; Department of Chemistry, Parke-Davis Pharmaceutical Research,; Division of Warner-Lambert Company, Ann Arbor, Michigan 48106,; USA. Houng-Yau.Mei@wl.com; TAR RNA represents an attractive target for the intervention of human immunodeficiency virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule inhibitors of the HIV-1 Tat-TAR interaction that target the RNA, not the protein. The chemical structures and RNA binding characteristics of t
Actinomycin D inhibition of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase and nucleocapsid protein.: Biochemistry. 1998 Oct 6;37(40):14213-21. Unique Identifier : AIDSLINE MED/98434396; Davis WR; Gabbara S; Hupe D; Peliska JA; Department of Biological Chemistry, University of Michigan; Medical School, Ann Arbor 48109-0606, USA.; Actinomycin D was found to be a potent inhibitor of HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions. Using an oligonucleotide model system, actinomycin D inhibition of DNA strand transfer was examined to elucidate the mechanism of inhibition and further define the mechanism of DNA strand transfer.
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.: Biochemistry. 1998 Oct 13;37(41):14394-403. Unique Identifier : AIDSLINE PDB/R1RT4SF; Ren J; Esnouf RM; Hopkins AL; Warren J; Balzarini J; Stuart DI; Stammers DK; Laboratory of Molecular Biophysics, Oxford, UK.; The carboxanilides are nonnucleoside inhibitors (NNIs) of HIV-1 reverse transcriptase (RT), of potential clinical importance. The compounds differ in potency and in their retention of potency in the face of drug resistance mutations. Whereas UC-84, the prototype compound, only weakly inhibits many RTs bearing single p
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.: Biochemistry. 1998 Oct 20;37(42):14683-91. Unique Identifier : AIDSLINE PDB/0000; Arold S; O'Brien R; Franken P; Strub MP; Hoh F; Dumas C; Ladbury JE; Centre de Biochimie Structurale, UMR C9955 CNRS, U414 INSERM,; Universite Montpellier 1, France.; Understanding the issue of specificity imposed in the interactions of SH3 domains has largely been addressed in studies investigating the interaction of proline-rich amino acid sequences derived from potential ligands for these domains. Although the interaction with this motif forms an essential platform in the bindin
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.: Biochemistry. 1998 Oct 27;37(43):15042-9. Unique Identifier : AIDSLINE MED/99007120; Ala PJ; Huston EE; Klabe RM; Jadhav PK; Lam PY; Chang CH; Experimental Station, DuPont Pharmaceuticals, Wilmington,; Delaware 19880, USA.; The long-term therapeutic benefit of HIV antiretroviral therapy is still threatened by drug-resistant variants. Mutations in the S1 subsite of the protease are the primary cause for the loss of sensitivity toward many HIV protease inhibitors , including our first-gen
A polyethylene glycol copolymer for carrying and releasing multiple copies of cysteine-containing peptides.: Bioconjug Chem. 1998 Sep-Oct;9(5):612-7. Unique Identifier : AIDSLINE MED/98407922; Huang SY; Pooyan S; Wang J; Choudhury I; Leibowitz MJ; Stein S; Center for Advanced Biotechnology and Medicine and Chemistry; Department, Rutgers University, New Brunswick, New Jersey; 08903-2101, USA.; Two different methods were developed to prepare an adduct of a poly(ethylene glycol)-lysine copolymer with either cysteamine or 1-amino-2-methyl-2-propanethiol. Cysteine-containing peptides could then be disulfide-linked to the thiol groups on the polymer in a facile manner. In the described procedures, a coupling rat
[Disseminated histoplasmosis in AIDS patients. A study of 2 cases and review of the Spanish literature]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):316-21. Unique Identifier : AIDSLINE MED/99026409; Benito N; Garcia Vazquez E; Blanco A; de Gorgolas M; Gadea I; Escalonilla P; Fernandez Guerrero ML; Division de Enfermedades Infecciosas, (Servicio de Medicina; Interna), Fundacion Jimenez Diaz, Universidad Autonoma de; Madrid.; The characteristics of two cases of histoplasmosis in AIDS patients in our institution are presented together with a review of the 11 cases published in Spain since 1988 in addition to the current knowledge on histoplasmosis in patients with human immunodeficiency virus infection (H
[Infection by Pseudomonas aeruginosa in patients with human immunodeficiency virus infection. Descriptive study of 35 cases]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):322-7. Unique Identifier : AIDSLINE MED/99026410; Elvira J; Lopez-Suarez A; Clavo A; Pina JM; Segura E; Perez-Guzman E; Giron JA; Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta; del Mar, Cadiz.; OBJECTIVE: Analysis of the spectrum of diseases attributed to Pseudomonas aeruginosa in patients with coinfection with the immunodeficiency virus (HIV). METHODS: Retrospective study of 35 cases of coinfection with P. aeruginosa-HIV, attended from 1985 until 1995. Analysis of putative factors implicated in mortality se
[Fibrin-ring granulomas in an AIDS patient and disseminated infection by Mycobacterium avium-intracellulare (letter)]: Enferm Infecc Microbiol Clin. 1998 Aug-Sep;16(7):343-4. Unique Identifier : AIDSLINE MED/99026415; Payeras A; Torres JJ; Andreu H; Bassa A; Bosch MA; Buades J
Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy.: Hum Gene Ther. 1998 Jul 20;9(11):1627-42. Unique Identifier : AIDSLINE MED/98357534; Marasco WA; Chen S; Richardson JH; Ramstedt U; Jones SD; Department of Cancer Immunology & AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, MA 02115, USA.
Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen.: Hum Gene Ther. 1998 Aug 10;9(12):1719-29. Unique Identifier : AIDSLINE MED/98386036; Sallberg M; Hughes J; Javadian A; Ronlov G; Hultgren C; Townsend K; Anderson CG; O'Dea J; Alfonso J; Eason R; Murthy KK; Jolly DJ; Chang SM; Mento SJ; Milich D; Lee WT; Chiron Technologies Center for Gene Therapy, San Diego, CA; 92121-1204, USA.; Cytotoxic T lymphocyte (CTL) activity and CD4+ helper T cell responses to the hepatitis B virus (HBV) core antigen (HBcAg) have been implicated in clearance of acute and chronic HBV infections. We showed that intramuscular injections of a novel recombinant retroviral vector expressing an HBcAg-neomycin phosphotransfer
DNA vaccination for leishmaniasis [comment]: Hum Gene Ther. 1998 Sep 1;9(13):1849-50. Unique Identifier : AIDSLINE MED/98412454; Paillard F
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.: Hum Gene Ther. 1998 Sep 1;9(13):1885-98. Unique Identifier : AIDSLINE MED/98412458; Harrod KS; Hermiston TW; Trapnell BC; Wold WS; Whitsett JA; Division of Pulmonary Biology, Children's Hospital Medical; Center, Cincinnati, OH 45229, USA.; Herein, we report that the adenovirus E3-14.7K protein inhibits the inflammatory response to adenovirus in transgenic mice in which the E3-14.7K gene was selectively expressed in the respiratory epithelium, using the human surfactant protein C (SP-C) promoter. E3-14.7K mRNA and protein were detected specifically in th
Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis [see comments]: Hum Gene Ther. 1998 Sep 1;9(13):1899-907. Unique Identifier : AIDSLINE MED/98412459; Walker PS; Scharton-Kersten T; Rowton ED; Hengge U; Bouloc A; Udey MC; Vogel JC; Dermatology Branch, NCI, National Institutes of Health, Bethesda,; MD 20892, USA.; Genetic immunization is a promising gene therapy approach for the prevention and treatment of infectious disease. Plasmid DNA expressing genes of pathogens is directly introduced into host cells and specific cell-mediated and/or humoral immune responses are elicited against the encoded protein. Leishmaniasis is a sign
Photo quiz. Chronic cutaneous verrucous varicella-zoster infection.: Clin Infect Dis. 1998 Aug;27(2):259, 380-1. Unique Identifier : AIDSLINE MED/98375638; Berger AA; Anekthananon T; Bonnez W; Evans T; Department of Medicine, University of Rochester Medical Center,; New York, USA.
Herpes simplex virus infections of the central nervous system in human immunodeficiency virus-infected patients: clinical management by polymerase chain reaction assay of cerebrospinal fluid.: Clin Infect Dis. 1998 Aug;27(2):303-9. Unique Identifier : AIDSLINE MED/98375645; Cinque P; Vago L; Marenzi R; Giudici B; Weber T; Corradini R; Ceresa D; Lazzarin A; Linde A; Department of Infectious Diseases, Scientific Institute San; Raffaele, Milan, Italy.; A duplex polymerase chain reaction (PCR) assay for DNA from herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) was applied to cerebrospinal fluid (CSF) from 918 human immunodeficiency virus (HIV)-infected patients with neurological symptoms. HSV-1 or HSV-2 (HSV-1/2) DNA was found in 19 patients (2%). For the 258 patie
Cytomegalovirus polyradiculopathy in patients with AIDS.: Clin Infect Dis. 1998 Aug;27(2):345-52. Unique Identifier : AIDSLINE MED/98375650; Anders HJ; Goebel FD; Medizinische Poliklinik, Ludwig-Maximilian University, Munich,; Germany.; Using the MEDLINE database, we evaluated 103 cases of AIDS-related cytomegalovirus ( CMV ) polyradiculopathy (PRP). In 13% of cases, PRP was the initial manifestation of AIDS. Hyporeflexia was present in 100% of cases; lower li
Report of invasive Rhodococcus equi infections in Taiwan, with an emphasis on the emergence of multidrug-resistant strains.: Clin Infect Dis. 1998 Aug;27(2):370-5. Unique Identifier : AIDSLINE MED/98375654; Hsueh PR; Hung CC; Teng LJ; Yu MC; Chen YC; Wang HK; Luh KT; Department of Laboratory Medicine, National Taiwan University; Hospital, Taipei, Taiwan.; From November 1995 to October 1997, seven patients with invasive infections due to Rhodococcus equi were treated in Taiwan . Four patients had pulmonary lesions, and one each of the remaining three patients had a recurrent Port-A-Cat
Detection of Enterocytozoon bieneusi in two human immunodeficiency virus-negative patients with chronic diarrhea by polymerase chain reaction in duodenal biopsy specimens and review.: Clin Infect Dis. 1998 Aug;27(2):394-8. Unique Identifier : AIDSLINE MED/98375660; Gainzarain JC; Canut A; Lozano M; Labora A; Carreras F; Fenoy S; Navajas R; Pieniazek NJ; da Silva AJ; del Aguila C; Servicio de Medicina Interna, Hospital Santiago Apostol,; Vitoria, Spain.; Intestinal microsporidiosis has been associated traditionally with severely immunocompromised patients with AIDS. We describe two new cases of intestinal microsporidiosis due to Enterocytozoon bieneusi in human immunodeficiency virus-negative adults. Both patients pres
An open-label pilot study of the efficacy and tolerability of once-daily didanosine versus twice-daily didanosine.: Clin Infect Dis. 1998 Aug;27(2):400-1. Unique Identifier : AIDSLINE MED/98375662; Keiser P; Turner D; Ramilo O; Kvanli MB; Smith JW; Nassar N; University of Texas Southwestern Medical Center at Dallas, USA.
Clinical problems posed by multiresistant nonfermenting gram-negative pathogens.: Clin Infect Dis. 1998 Aug;27 Suppl 1:S117-24. Unique Identifier : AIDSLINE MED/98376539; Quinn JP; Department of Medicine, University of Illinois at Chicago,; College of Medicine, USA.; In this review I will briefly survey the role of Pseudomonas aeruginosa, Acinetobacter baumanii, Stenotrophomonas maltophilia, and Burkholderia cepacia as opportunistic pathogens. A common feature of these organisms is intrinsic resistance to multiple antibiotics. All of these organisms can be recovered from the envir
[Discriminative value for AIDS case of erythrocyte sedimentation rate, immunoglobulins IgA and IgM, and beta 2-microglobulin in combination with the CD4+ lymphocyte count]: An Med Interna. 1998 Aug;15(8):411-4. Unique Identifier : AIDSLINE MED/98453706; Perez de Oteyza C; Menendez Martinez MA; Muro Garcia R; Perez Aznar C; Barberan Lopez J; Departamento de Medicina Interna, Hospital Militar Universitario; Gomez Ulla, Universidad Complutense, Madrid.; OBJECTIVE: To establish the probability to discriminate the evolution to AIDS case in relation to the common laboratory parametres in the follow-up of the HIV infection. MATERIAL AND METHODS: We have studied a cohort of 118 patients (1986-95) with HIV infection, 14 of them (12%) had clinical criteria for AIDS (CDC/9
[Tuberculosis and HIV infection. Clinical characteristics and diagnosis]: An Med Interna. 1998 Aug;15(8):415-20. Unique Identifier : AIDSLINE MED/98453707; Lado Lado FL; Barrio Gomez E; Cabarcos Ortiz de Barron A; Carballo Arceo E; Sanchez Leira J; Perez del Molino ML; Antunez Lopez JR; Servicio de Medicina Interna, Complexo Hospitalario; Universitario, Facultad de Medicina, Santiago de Compostela, La; Coruna.; OBJECTIVE: To analyze the clinical characteristics and diagnose of tuberculosis in patients infected by human immunodeficiency virus in our setting. METHODS: We have revised the clinical, microbiological and histological characteristics of 92 cases diagnosed tuberculosis in seropositive patients, during a span time of
[Which are the vaccines that human immunodeficiency virus infected patients must receive?]: An Med Interna. 1998 Aug;15(8):439-42. Unique Identifier : AIDSLINE MED/98453713; Valencia Ortega ME; Gonzalez Lahoz JM; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; Patients with aids are at increased risk of opportunistic and non opportunistic infections. It is now known that the incidence can be reduced by prophylactic measures and/or the use of vaccines. HIV infection produces an elevated frequency of severe pneumococcal disease with a rate of bacteriemia caused by Streptococc
Construction of a continuous stopping boundary from an alpha spending function.: Biometrics. 1998 Sep;54(3):1061-71. Unique Identifier : AIDSLINE MED/98422646; Betensky RA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA. betensky@sdac.harvard.edu; Lan and DeMets (1983, Biometrika 70, 659-663) proposed a flexible method for monitoring accumulating data that does not require the number and times of analyses to be specified in advance yet maintains an overall Type I error, alpha. Their method amounts to discretizing a preselected continuous boundary by clumping th
Statistical methods for assessing differential vaccine protection against human immunodeficiency virus types.: Biometrics. 1998 Sep;54(3):799-814. Unique Identifier : AIDSLINE MED/98422632; Gilbert PB; Self SG; Ashby MA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) is extremely diverse. In assessing the utility of an HIV-1 vaccine, an important issue is the possibility of differential protection. We discuss statistical methods of inferring how the vaccine efficacy may vary with viral type from data that would be collected from a ra
A semiparametric Bayesian approach to the random effects model.: Biometrics. 1998 Sep;54(3):921-38. Unique Identifier : AIDSLINE MED/98422636; Kleinman KP; Ibrahim JG; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; In longitudinal random effects models, the random effects are typically assumed to have a normal distribution in both Bayesian and classical models. We provide a Bayesian model that allows the random effects to have a nonparametric prior distribution. We propose a Dirichlet process prior for the distribution of the ra
Approaches for optimal sequential decision analysis in clinical trials.: Biometrics. 1998 Sep;54(3):964-75. Unique Identifier : AIDSLINE MED/98422639; Carlin BP; Kadane JB; Gelfand AE; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55455, USA. brad@muskie.biostat.umn.edu; Unlike traditional approaches, Bayesian methods enable formal combination of expert opinion and objective information into interim and final analyses of clinical trial data. However, most previous Bayesian approaches have based the stopping decision on the posterior probability content of one or more regions of the pa
Estimating a treatment effect from multidimensional longitudinal data.: Biometrics. 1998 Sep;54(3):976-88. Unique Identifier : AIDSLINE MED/98422640; Gray SM; Brookmeyer R; Department of Biostatistics, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.; gray@jhu.edu; Multidimensional longitudinal data result when researchers measure an outcome through time that is quantified by many different response variables. These response variables are often defined on different numerical scales. The objective of this paper is to present a method to summarize and estimate an overall treatment
Effects of the ribavirin-interferon alpha combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients.: Cytokine. 1998 Aug;10(8):635-44. Unique Identifier : AIDSLINE MED/98390177; Martin J; Navas S; Quiroga JA; Pardo M; Carreno V; Department of Hepatology, Fundacion Jimenez Diaz, Madrid,; Spain.; The effects of ribavirin and interferon (IFN) alpha have been investigated on cultured peripheral blood mononuclear cells, obtained from 15 patients with chronic hepatitis C virus (HCV) infection. At clinically relevant serum concentrations achieved during therapeutic administration, ribavirin did inhibit moderately t
Fine needle aspiration (FNA) in HIV+ patients [comment]: Cytopathology. 1998 Aug;9(4):219-21. Unique Identifier : AIDSLINE MED/98376550; Buley ID; Department of Cellular Pathology, John Radcliffe Hospital,; Oxford, UK.
Fine needle aspiration (FNA) in HIV+ patients: results from a series of 655 aspirates [see comments]: Cytopathology. 1998 Aug;9(4):222-9. Unique Identifier : AIDSLINE MED/98376551; Ellison E; Lapuerta P; Martin SE; Department of Pathology, University of Southern California, Los; Angeles 90033, USA.; There are many selected small series or case reports of FNAs in patients with HIV infection, but large series are rare and epidemic s characteristics have evolved over time. The current study, from a large public hospital in the USA, included women as well as men, hetero- and homosexuals, in-patients and out-patients,
Diagnostic utility of fine needle aspiration (FNA) cytology in HIV-infected patients with lymphadenopathy [see comments]: Cytopathology. 1998 Aug;9(4):230-9. Unique Identifier : AIDSLINE MED/98376552; Reid AJ; Miller RF; Kocjan GI; Department of Sexually Transmitted Diseases, University College; London Medical School, UK.; Sixty-five FNA cytology procedures were performed on lymph nodes in 52 HIV+ patients. Cervical lymph nodes were the commonest site of FNA cytology investigation (54%). The diagnoses were persistent generalized lymphadenopathy (38%), infection (17%), and malignancy (11%). Diagnosis could not be rendered in 25% of FNA c
Captopril prevents nephropathy in HIV-transgenic mice.: J Am Soc Nephrol. 1998 Aug;9(8):1441-7. Unique Identifier : AIDSLINE MED/98361131; Bird JE; Durham SK; Giancarli MR; Gitlitz PH; Pandya DG; Dambach DM; Mozes MM; Kopp JB; Division of Cardiovascular Drug Discovery, Bristol-Myers Squibb,; Princeton, New Jersey 08543, USA.; Transgenic mice (T26) bearing the envelope, regulatory, and accessory genes of HIV- I develop renal disease resembling human HIV-associated nephropathy (HIVAN). Effects of vehicle (VEH) and the angiotensin-converting enzyme inhibitor captopril (CAP) were examined in wild-type (WT) or T26 mice treated from 7 to 100 d o
Hepatitis viruses under immunosuppressive agents.: J Gastroenterol Hepatol. 1998 Jan;13(1):14-20. Unique Identifier : AIDSLINE MED/98407584; Liaw YF; Liver Research Unit, Chang Gung Memorial Hospital and Medical; College, Taipei, Taiwan.; Clinical and experimental studies have shown that T cell-mediated immune mechanisms are involved in the pathogenesis of hepatitis B virus (HBV) and hepatitis C virus infection. Immunosuppressants may impair T cell function and thereby reduce immune-mediated hepatocytolysis and virus clearance. In addition, corticoster
Diagnostic value of anti-hepatitis D virus (HDV) antibodies revisited: a study of total and IgM anti-HDV compared with detection of HDV-RNA by polymerase chain reaction.: J Gastroenterol Hepatol. 1998 Jan;13(1):57-61. Unique Identifier : AIDSLINE MED/98407591; Huang YH; Wu JC; Sheng WY; Huo TI; Chang FY; Lee SD; Department of Medicine, Veterans General Hospital-Taipei and; National Yang-Ming University School of Medicine, Taiwan,; Republic of China.; A high serum titre (> or = 1000 or > or = 5000) of total antibody to hepatitis D virus (anti-HDV) and positive for immunoglobulin (Ig)M anti-HDV have been used to represent HDV replication, while reverse transcription-polymerase chain reaction (RT-PCR) is currently the most sensitive assay for detecting HDV viraemia.
Prospective follow-up study of hepatitis C virus infection in patients undergoing maintenance haemodialysis: comparison among haemodialysis units.: J Gastroenterol Hepatol. 1998 Jun;13(6):604-9. Unique Identifier : AIDSLINE MED/98381193; Kobayashi M; Tanaka E; Oguchi H; Hora K; Kiyosawa K; Second Department of Internal Medicine, Shinshu University School; of Medicine, Matsumoto, Japan.; A prospective follow-up study on hepatitis C virus (HCV) infection was conducted in seven haemodialysis units from April 1990 to March 1995. A total of 634 patients were undergoing maintenance haemodialysis in the seven units. Of those, 302 patients participated in the follow-up study; 179 were initially HCV antibody
Hepatobiliary tuberculosis.: J Gastroenterol Hepatol. 1998 Aug;13(8):833-9. Unique Identifier : AIDSLINE MED/98405587; Alvarez SZ; Department of Medicine, Faculty of Medicine and Surgery,; University of Santo Tomas, Manila, Philippines.; sza@i-manila.com.ph; Tuberculosis is known to involve the liver in different ways. The term hepatobiliary tuberculosis refers to the localized form of hepatic tuberculosis as a distinct clinical entity, with signs and symptoms related to the hepatobiliary tract. Its clinical features and the different diagnostic aids used in its diagnosis
Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections.: Semin Immunol. 1998 Oct;10(5):383-90. Unique Identifier : AIDSLINE MED/99017922; Biron CA; Department of Molecular Microbiology and Immunology, Division of; Biology and Medicine, Brown University, Providence, RI 02912,; USA.; Innate cytokine responses are important mediators of early defense against infections. Certain of their effects can be delivered directly to activate protective mechanisms in infected cells. Others activate innate immune cells, including natural killer (NK) cells and macrophages, to mediate defense. Still others shape
Bridging the gap: reflections on the 12th World Aids Conference [editorial]: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):17-8. Unique Identifier : AIDSLINE MED/98414892; Sowell R
Revision of HIV center medical staging scale.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):19-23. Unique Identifier : AIDSLINE MED/98414893; McCain NL; Lyon DE; Higginson R; Settle J; Robins JL; Fisher EJ; School of Nursing, Virginia Commonwealth University, Richmond; 23298, USA. nmccain@hsc.vcu.edu; HIV-related symptomatology represents both an indirect measure of immune functioning and a clinically significant indicator of disease progression. The most widely used classification system for HIV-related symptomatology is the Center for Disease Control (CDC) system. Although the CDC scale has widely recognized clin
Improved gastrointestinal tolerance and palatability of didanosine in adults by the use of pediatric power formulation.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):27-31. Unique Identifier : AIDSLINE MED/98414894; Dodge RT; Shipp KW; Miralles GD; Duke University Medical Center, Division of Infectious Diseases,; Durham, North Carolina, USA. robert.dodge@duke.edu; Administration of didanosine (ddI) as buffered tablets is complicated by its poor palatability. The tolerance and palatability of pediatric powder ddI in an adult population of subjects with HIV infection as compared with buffered ddI tablets was compared. Twenty HIV-infected, were enrolled in a randomized crossover t
Triazole therapy for mucocutaneous candidiasis in HIV-infected patients.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):36-44. Unique Identifier : AIDSLINE MED/98414895; Thomas CJ; University of Alabama at Birmingham, Department of Medicine, USA.; Mucocutaneous candidiasis, such as oropharyngeal candidiasis, esophageal candidiasis, and vulvovaginal candidiasis, are common problems in patients with HIV infection. These conditions adversely affect patient quality of life and morbidity status. New oral triazole agents provide improved treatment options for patient
Factors associated with vaginal yeast infections in HIV-positive women.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):47-52. Unique Identifier : AIDSLINE MED/98414896; Williams AB; Andrews S; Tashima K; Mezger J; Yu C; Yale School of Nursing, New Haven, CT 06536-0740, USA.; To better understand factors associated with symptomatic and asymptomatic vulvovaginal candidiasis, including the role of immune compromise and patient self-report, a cross-sectional analysis of factors associated with the isolation of yeast from vaginal swabs and clinical diagnosis of Candida vaginitis (CV) among 184
Nursing practice for HIV/AIDS fever care: a descriptive study.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):53-60. Unique Identifier : AIDSLINE MED/98414897; Jones SG; HIV Critical Pathways Program, Mount Sinai Medial Center, Miami; Beach, Florida, USA.; Nurses often perceive fever in relation to the impact it has on specific patient populations. Fever in HIV/AIDS patients is a common symptom. This descriptive study explored how nurses in AIDS care defined and described fever in HIV/AIDS patients and used nursing interventions for fever management. Seventy-five regist
Practice what we preach? HIV knowledge, beliefs, and behaviors of adolescents and adolescent peer educators.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):61-72. Unique Identifier : AIDSLINE MED/98414898; Villarruel AM; Jemmolt LS; Howard M; Taylor L; Bush E; University of Pennsylvania, School of Nursing, USA.; The purpose of this article is to (a) describe the knowledge, beliefs, and sexual behaviors of urban adolescents and adolescent peer educators, and (b) identify elements needed to design effective HIV/AIDS prevention programs for out-of-school youth. Thirty-three predominantly African American adolescents (female = 14
HIV/AIDS in migrant and seasonal farm workers.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):80-3. Unique Identifier : AIDSLINE MED/98414899; Aranda-Naranjo B; Gaskins S; University of Texas, Health Sciences Center at San Antonio, USA.
Clinicians' antiretroviral medications guide.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):84-6. Unique Identifier : AIDSLINE MED/98414900; Martin JE; Pindaro C; HIV Out-patient Clinic, Medical Center of Louisiana, New Orleans,; USA.
Reviewing the literature.: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):87-9. Unique Identifier : AIDSLINE MED/98414901; Sharts-Hopko NC; Villanova University, College of Nursing, USA.
Group sex in gay men: its meaning and HIV prevention implications [letter]: J Assoc Nurses AIDS Care. 1998 Sep-Oct;9(5):90-1. Unique Identifier : AIDSLINE MED/98414902; Simmons P
[Immunoenzyme system for detection of antibodies in their complexes with HIV-1 antigens]: Biull Eksp Biol Med. 1998 Aug;126(8):189-92. Unique Identifier : AIDSLINE MED/98450397; Abelian AV; Shchelkanov MIu; Burunova VV; Kabdulova DO; Karamov EV
Burnout as a clinical entity--its importance in health care workers.: Occup Med (Oxf). 1998 May;48(4):237-50. Unique Identifier : AIDSLINE MED/99016804; Felton JS; Department of Medicine, University of California, Irvine, USA.; Burnout, viewed as the exhaustion of physical or emotional strength as a result of prolonged stress or frustration, was added to the mental health lexicon in the 1970s, and has been detected in a wide variety of health care providers. A study of 600 American workers indicated that burnout resulted in lowered productio
Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses.: Blood. 1998 Oct 15;92(8):2668-71. Unique Identifier : AIDSLINE MED/98438319; Bonecchi R; Sozzani S; Stine JT; Luini W; D'Amico G; Allavena P; Chantry D; Mantovani A; Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.; Macrophage-derived chemokine (MDC) is a CC chemokine that recognizes the CCR4 receptor and is selective for T helper 2 (Th2) versus T helper 1 (Th1) cells. The present study was designed to investigate the effect of the prototypic Th2/Th1 cytokines, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma), on the product
Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected.: Blood. 1998 Oct 15;92(8):2681-7. Unique Identifier : AIDSLINE MED/98438321; Tisdale JF; Stewart AK; Dickstein B; Little RF; Dube I; Cappe D; Dunbar CE; Brown KE; Hematology Branch, National Heart, Lung and Blood Institute,; Bethesda, MD, USA.; Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig et al, Science 276:1851, 1997). We sought to confirm these observation
Flow cytometry in situ polymerase chain reaction as an innovative approach to HIV-1 proviral DNA detection.: Eur J Histochem. 1998;42(2):137-41. Unique Identifier : AIDSLINE MED/98397537; Gibellini D; Zauli G; Re MC; Furlini G; La Placa M; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; In situ polymerase chain reaction represents an intriguing method to couple the sensitivity of PCR technology with the preservation of cell morphology. The target of this technique is the detection of specific DNA or retrotranscribed RNA inside the cell. In this brief report, we describe an in situ polymerase chain re
Viral inactivation of human bone tissue using supercritical fluid extraction.: ASAIO J. 1998 Jul-Aug;44(4):289-93. Unique Identifier : AIDSLINE MED/98346484; Fages J; Poirier B; Barbier Y; Frayssinet P; Joffret ML; Majewski W; Bonel G; Larzul D; Ecole des Mines, Albi, France.; A new bone tissue process using supercritical carbon dioxide fluid extraction (SFE) has been evaluated for its ability to inactivate or eliminate viruses. Four viruses, human immunodeficiency virus type 1 (HIV-1), Sindbis virus, polio Sabin type I virus, and pseudorabies virus (PRV), were exposed to four different pro
Flow cytometry analysis of peripheral blood lymphocytes from patients with bullous pemphigoid.: Dermatology. 1998;197(2):137-40. Unique Identifier : AIDSLINE MED/98402414; Jouen-Beades F; Joly P; Heron F; Paris E; Lauret P; Tron F; Groupe de Recherche en Immunopathologie, Institut Federatif de; Recherche Multidisciplinaire sur les Peptides, Rouen, France.; BACKGROUND: Bullous pemphigoid (BP) is an autoimmune disease observed in elderly subjects in which alteration of peripheral blood lymphocyte subset repartition has been described. OBJECTIVE: To evaluate peripheral blood lymphocyte subsets from BP patients and identify immunologic changes that can be assigned either to
HIV-Associated eosinophilic folliculitis and follicular mucinosis.: Dermatology. 1998;197(2):178-80. Unique Identifier : AIDSLINE MED/98402423; Buezo GF; Fraga J; Abajo P; Rios L; Dauden E; Garcia-Diez A; Department of Dermatology, Hospital Universitario de la Princesa,; Universidad Autonoma, Madrid, Spain.; The term HIV-associated eosinophilic folliculitis (EF) designates an idiopathic dermatitis that appears in HIV-infected patients with different clinical manifestations but with a distinctive histological feature characterized by a predominantly eosinophilic infiltrate in the follicular infundibula. On the other side,
Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1.: Mamm Genome. 1998 Oct;9(10):849-52. Unique Identifier : AIDSLINE GENBANK/AF016898; Meyer NP; Johansen LM; Tae HJ; Budde PP; Williams KL; Taparowsky EJ; Department of Biological Sciences, Purdue University, West; Lafayette, Indiana 47907-1392, USA.
Influence of delayed viral production on viral dynamics in HIV-1 infected patients.: Math Biosci. 1998 Sep;152(2):143-63. Unique Identifier : AIDSLINE MED/98453897; Mittler JE; Sulzer B; Neumann AU; Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National; Laboratory, MS-K710, NM 87545, USA. jmittler@t10.lanl.gov; We present and analyze a model for the interaction of human immunodeficiency virus type 1 (HIV-1) with target cells that includes a time delay between initial infection and the formation of productively infected cells. Assuming that the variation among cells with respect to this intracellular delay can be approximat
Protease inhibitors in antiviral therapy of paediatric HIV disease [letter]: Acta Paediatr. 1998 Jul;87(7):814-6. Unique Identifier : AIDSLINE MED/98387716; Manfredi R; Monari P; Donzelli C; Furlini G; Re MC; Chiodo F
Similar birthweight in children born to HIV-2 infected and HIV-negative women in Guinea-Bissau [letter]: Acta Paediatr. 1998 Jul;87(7):816-7. Unique Identifier : AIDSLINE MED/98387717; Norrgren H; Andersson S; Dias F; Alves A; Naucler A; Biberfeld G
Apathy, depression, and cognitive performance in HIV-1 infection.: J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):320-9. Unique Identifier : AIDSLINE MED/98371829; Castellon SA; Hinkin CH; Wood S; Yarema KT; Department of Psychology, University of California-Los Angeles; 90024, USA. scastell@ucla.edu; The authors examined the relationship between apathy, depression, and cognitive performance in 48 HIV-1-seropositive and 21 seronegative (control) subjects, using reaction time (RT) and working memory tasks. Apathy, but not depression, was associated with working memory deficits among HIV-seropositive subjects. The co
Neurobehavioral correlates of perceived mental and motor slowness in HIV infection and AIDS.: J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):343-50. Unique Identifier : AIDSLINE MED/98371832; Lopez OL; Wess J; Sanchez J; Dew MA; Becker JT; Department of Neurology, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; The authors assessed 72 human immunodeficiency virus (HIV)-infected patients with a self-rating slowness scale (SRSS) concerning mental and motor slowness in their activities of daily living. In order to understand the relationship between complaints of slowness and predictor variables, the investigators developed a p
Expression and purification of HIV-I p15NC protein in Escherichia coli.: Protein Expr Purif. 1998 Oct;14(1):54-64. Unique Identifier : AIDSLINE MED/98432900; Ozturk DH; Erickson-Viitanen S; Virology Department, The DuPont Merck Pharmaceutical Company,; Experimental Station, Building E336/1B, Wilmington, Delaware,; 19880-0336, USA. derya.h.ozturk@dupontpharma.com; An efficient method for the expression and purification of nucleocapsid precursor protein (p15NC) from HIV-I (BH 10 isolate) was developed and used to obtain large quantities of this viral protein for structural studies, protein biochemistry, and high-throughput screening efforts. We have engineered an existing p15NC
Effect of promoters and signal sequences on the production of secreted HIV-1 gp120 protein in the baculovirus system.: Protein Expr Purif. 1998 Oct;14(1):8-12. Unique Identifier : AIDSLINE MED/98432894; Golden A; Austen DA; van Schravendijk MR; Sullivan BJ; Kawasaki ES; Osburne MS; Procept, Inc., 840 Memorial Drive, Cambridge, Massachusetts,; 02139, USA.; We compared insect cell production levels of secreted HIV-1 gp120 glycoprotein encoded by five different baculovirus expression constructs. Combinations consisting of one of two baculovirus promoters (very late or hybrid late/very late) and one of three different signal sequences [human tissue plasminogen activator (t
Hyperthyroidism due to lymphoma involving the thyroid gland in a patient with acquired immunodeficiency syndrome: case report and review of the literature.: Thyroid. 1998 Aug;8(8):673-7. Unique Identifier : AIDSLINE MED/98407380; Samuels MH; Launder T; Division of Endocrinology, Metabolism, and Clinical Nutrition,; Oregon Health Sciences University, Portland 97201, USA.; A 31-year old woman with acquired immunodeficiency syndrome (AIDS) and a history of lymphoma presented with a 2-week history of severe hyperthyroid symptoms and new-onset neck swelling. On physical examination, she was found to be clinically hyperthyroid, with a markedly enlarged, diffuse, tender goiter. Thyroid funct
Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice.: Int Arch Allergy Immunol. 1998 Sep;117 Suppl 1:14-9. Unique Identifier : AIDSLINE MED/98432878; Kasai M; Kumano K; Kurasawa K; Nakao A; Saito Y; Iwamoto I; Department of Internal Medicine II, Chiba University School of; Medicine, Chiba City, Japan.; To determine whether the costimulatory signal via CD28/B7 interaction is required for causing allergic inflammation, we examined the effect of administration of CTLA4-Ig, a fusion protein of the extracellular domain of CTLA4 and human IgG1-constant region, at the time of sensitization, on antigen-induced eosinophil in
The involvement of CD80 and CD86 costimulatory molecules in the induction of eosinophilia in mice infected with Nippostrongylus brasiliensis.: Int Arch Allergy Immunol. 1998 Sep;117 Suppl 1:2-4. Unique Identifier : AIDSLINE MED/98432875; Huang Y; Watanabe N; Ohtomo H; Department of Tropical Medicine, Jikei University School of; Medicine, Tokyo, Japan.; The costimulatory signal provided by the interaction between CD28 and its ligands, CD80 and CD86, is critical for T cell activation. The requirement of CD80 and CD86 in T cell activation for eosinophilia and IgE production was examined in mice infected with the nematode parasite Nippostrongylus brasiliensis. Combined
Infection rates are still rising [letter]: Can Fam Physician. 1998 Sep;44:1800, 1803. Unique Identifier : AIDSLINE MED/99006087; Salmon B
Oral manifestations of human immunodeficiency virus-infected patients in Taiwan.: J Formos Med Assoc. 1998 Sep;97(9):600-5. Unique Identifier : AIDSLINE MED/99011619; Chiang CP; Chueh LH; Lin SK; Chen MY; School of Dentistry, College of Medicine, National Taiwan; University, Taipei, Taiwan.; To understand the characteristic clinical features of human immunodeficiency virus (HIV)-related oral lesions and determine the prevalence of various oral lesions in HIV-infected patients in Taiwan , we conducted a cross-sectional st
Informed consent. Policy has loopholes [letter]: BMJ. 1998 Oct 3;317(7163):949. Unique Identifier : AIDSLINE MED/99023101; Winter AJ; Mullis D; Radcliffe KW
Commission set up to deal with HIV infected doctors in Spain [news]: BMJ. 1998 Oct 10;317(7164):970. Unique Identifier : AIDSLINE MED/99023107; Bosch X
AIDS deaths fall by nearly one half [news]: BMJ. 1998 Oct 17;317(7165):1032. Unique Identifier : AIDSLINE MED/99033882; Gottlieb S
South African AIDS plan criticised [news]: BMJ. 1998 Oct 17;317(7165):1032. Unique Identifier : AIDSLINE MED/99033883; Sidley P
Oral treatment for hepatitis B gets approval in the United States [news]: BMJ. 1998 Oct 17;317(7165):1034. Unique Identifier : AIDSLINE MED/99033884; Josefson D
Factors associated with gonorrhoea in men aware of being positive for HIV infection: case-control study.: BMJ. 1998 Oct 17;317(7165):1052-3. Unique Identifier : AIDSLINE MED/98447548; Sadiq ST; Copas AJ; Johnson AM; Mortimer Market Centre, Camden and Islington Community NHS Trust,; London WC1E 6AU. tsadi@msn.com
Vaginal viricides-another way to tackle HIV transmission.: BMJ. 1998 Oct 17;317(7165):1053. Unique Identifier : AIDSLINE MED/98447549; Berger A
Post-exposure prophylaxis against HIV infection is hard to supply for expatriate staff [letter]: BMJ. 1998 Oct 17;317(7165):1084. Unique Identifier : AIDSLINE MED/98447571; Logie A
Socially desirable response tendency as a correlate of accuracy of self-reported HIV serostatus for HIV seropositive injection drug users.: Addiction. 1998 Aug;93(8):1191-7. Unique Identifier : AIDSLINE MED/99031443; Latkin CA; Vlahov D; Department of Health Policy and Management, Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA. clatkin@ihsph.edu; AIMS: This study examined the accuracy of self-reported HIV serostatus for injection drug users and the predictive validity of a measure of social desirability to detect inaccurate self-reports. DESIGN: Participants in the ALIVE study were provided testing for HIV antibodies and counseling every 6 months. In the separ
Adult T-cell leukemia/lymphoma in London: clinical experience of 21 cases.: Leuk Lymphoma. 1998 Sep;31(1-2):177-85. Unique Identifier : AIDSLINE MED/98385681; Pawson R; Richardson DS; Pagliuca A; Kelsey SM; Hoque S; Breuer J; Newland AC; Mufti GJ; Department of Hematological Medicine, King's College Hospital; School of Medicine and Dentistry, London, UK.; Adult T-cell leukemia/lymphoma (ATLL) is uncommon in the United Kingdom and has so far been restricted to people of Afro-Caribbean extraction. Between 1981 and 1995, 21 cases presented to 2 inner London teaching hospitals where 17% of the population are of Afro-Caribbean origin. Clinic
BCL-6 in aids-related lymphomas: pathogenetic and histogenetic implications.: Leuk Lymphoma. 1998 Sep;31(1-2):39-46. Unique Identifier : AIDSLINE MED/98385667; Gaidano G; Capello D; Gloghini A; Pastore C; Migliazza A; Quattrone S; Savinelli F; Buonaiuto D; Cilia AM; Perin T; Pasqualucci L; Canzonieri V; Saglio G; Dalla-Favera R; Carbone A; Department of Medical Sciences, University of Torino at Novara,; Italy. gaidano@med.no.unipmn.it; AIDS-related non-Hodgkin s lymphomas (AIDS-NHL) are classified into Burkitt s lymphoma, diffuse large cell lymphoma (DLCL), and body cavity based lymphoma. The molecular pathogenesis of AIDS-NHL is complex and involves the genetic alteration of several cancer related genes, including the BCL-6 proto-oncogene. BCL-6 en
HIV-1 reverse transcriptase is capable of elongating derivatives of sequence specific noncomplementary oligodeoxynucleotides.: Biochem Mol Biol Int. 1998 Aug;45(5):857-64. Un