CD4+ and CD8+ T cell subset distribution in the blood of small-bowel-grafted rats: modification during graft-versus-host disease. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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CD4+ and CD8+ T cell subset distribution in the blood of small-bowel-grafted rats: modification during graft-versus-host disease.

Transpl Int. 1998;11 Suppl 1:S467-71. Unique Identifier : AIDSLINE MED/98329743
Marni A; Forti D; Fulgenzi A; Corsi M; Cazzulani A; Ferrero ME; Department of Surgery Pizzamiglio II, Ospedale Niguarda, Milan,; Italy.

Abstract: We studied the modifications of blood T cell distribution following small-bowel allografting in rats under different experimental conditions. Group 1: ACI (RT1a) rats were used as small-bowel donors for ACI x Wistar (RT1y) F1 hybrid rats (WAF1) in which graft-versus-host disease (GVHD) developed. Group 2: WAF1 rats were used as small-bowel donors to ACI rats which developed rejection. Group 3: WAF1 rats received small bowel from ACI rats hyperimmunized for 10 days (by grafting them with WAF1 skin) and GVHD developed. Group 4: Wistar rats received small bowel from ACI rats hyperimmunized for 10 days (by Wistar skin) and bidirectional GVHD and rejection were assured. A second set of the same groups which were continuously administered with cyclosporine (15 mg/kg per day s.c. for 15 consecutive days) was also studied. Recipient peripheral blood lymphocytes, obtained at 7 and 15 days following small-bowel transplantation, were stained with monoclonal antibodies anti-rat CD4 and CD8 and then analyzed in an automated flow cytometer. A significant major reduction of CD4+/CD8+ T cell ratios was shown in rats that developed simultaneous GVHD and rejection with respect to ungrafted rats.
Keywords: JOURNAL ARTICLE Animal *CD4-CD8 Ratio Graft vs Host Disease/*BLOOD/IMMUNOLOGY Graft Rejection/*BLOOD/IMMUNOLOGY Intestine, Small/*IMMUNOLOGY/*TRANSPLANTATION Male Rats Rats, Inbred ACI Rats, WistarKWDjournalarticleanimalKWDcd4-cd8ratiograftvshostdisease/KWDblood/immunologygraftrejection/KWDblood/immunologyintestine,small/KWDimmunology/KWDtransplantationmaleratsrats,inbredacirats,wistar
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