Protective immunity induced by live attenuated simian immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Protective immunity induced by live attenuated simian immunodeficiency virus.

Curr Opin Immunol. 1998 Aug;10(4):436-43. Unique Identifier : AIDSLINE MED/98390160
Johnson RP; Desrosiers RC; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, MA 01772, USA.; pjohnson@warren.med.harvard.edu

Abstract: Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Antibody Formation Gene Products, nef Human Immunity, Cellular Macaca Mutagenesis Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PREVENTION & CONTROL Sterilization SIV/GENETICS/*IMMUNOLOGY Vaccination Vaccines, Attenuated/IMMUNOLOGY Viral Interference Viral Vaccines/*IMMUNOLOGYKWDjournalarticlereviewreview,tutorialanimalantibodyformationgeneproducts,nefhumanimmunity,cellularmacacamutagenesissimianacquiredimmunodeficiencysyndrome/immunology/KWDprevention&controlsterilizationsiv/genetics/KWDimmunologyvaccinationvaccines,attenuated/immunologyviralinterferenceviralvaccines/KWDimmunology
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