Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.

Curr Opin Immunol. 1998 Aug;10(4):444-9. Unique Identifier : AIDSLINE MED/98390161
Zajac AJ; Murali-Krishna K; Blattman JN; Ahmed R; Emory Vaccine Center, Emory University School of Medicine,; Atlanta, GA 30322, USA.

Abstract: The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Chronic Disease CD4-Positive T-Lymphocytes/*IMMUNOLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY Human Lymphocyte Transformation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Vaccination Viral Vaccines/*THERAPEUTIC USE Virus Diseases/DRUG THERAPY/*IMMUNOLOGYKWDjournalarticlereviewreview,tutorialanimalchronicdiseasecd4-positivet-lymphocytes/KWDimmunologycd8-positivet-lymphocytes/KWDimmunologyhumanlymphocytetransformationsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
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