Cytotoxic T cell responses to intracellular pathogens. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Cytotoxic T cell responses to intracellular pathogens.

Curr Opin Immunol. 1998 Aug;10(4):471-7. Unique Identifier : AIDSLINE MED/98390165
Stenger S; Modlin RL; Institut fur Klinische Mikrobiologie, Immunologie und Hygiene,; Universitat Erlangen, Germany.

Abstract: Host defense against intracellular pathogens is thought to require cytotoxic T cells. Recent studies have investigated the impact of host cell lysis and cytokine production by cytotoxic T lymphocytes on the fate of intracellular pathogens. The identification of two mechanisms of lysis induced by cytotoxic T lymphocytes--the granule exocytosis pathway and the Fas-FasL interaction--have provided new insight into the role of cytotoxic T lymphocyters in immunity to infection.
Keywords: JOURNAL ARTICLE Animal Antigens, CD95/IMMUNOLOGY Cytotoxicity, Immunologic CD8-Positive T-Lymphocytes/IMMUNOLOGY Human Intracellular Fluid Membrane Glycoproteins/IMMUNOLOGY Mice T-Lymphocytes, Cytotoxic/*IMMUNOLOGY Tuberculosis/IMMUNOLOGYKWDjournalarticleanimalantigens,cd95/immunologycytotoxicity,immunologiccd8-positivet-lymphocytes/immunologyhumanintracellularfluidmembraneglycoproteins/immunologymicet-lymphocytes,cytotoxic/KWDimmunologytuberculosis/immunology
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