AIDS-related malignancies. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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AIDS-related malignancies.

Ann Med. 1998 Aug;30(4):323-44. Unique Identifier : AIDSLINE MED/98455152
Smith C; Lilly S; Mann KP; Livingston E; Myers S; Lyerly HK; Miralles GD; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.

Abstract: In the US over one million persons are currently infected with the HIV, over half a million have had AIDS, and over 300,000 have died from AIDS. Worldwide, it is estimated that more than 17 million people are currently infected with HIV, and over 1,200,000 cases of AIDS have been reported to the World Health Organization. By some estimates, up to 40% of patients with AIDS will ultimately develop some form of cancer. Non-Hodgkin's lymphoma, Kaposi's sarcoma and invasive cervical cancer have a higher incidence in persons with HIV infection and all three are AIDS-defining illnesses. In addition, several reports suggest that a number of other malignancies may occur at an increased incidence in persons with HIV infection, including squamous-cell carcinoma of the head, neck and anus, plasmacytoma, melanoma, small-cell lung cancer, basal-cell cancer, and germ-cell tumours. Clinicians should become familiar with HIV-related malignancies as their incidence is expected to further increase as more effective therapies for HIV and associated opportunistic infections allow patients to live longer in an advanced state of immunodeficiency. In the current article, we will review the clinical and therapeutic aspects of the most common AIDS-related malignancies including non-Hodgkin's and Hodgkin's lymphomas, Kaposi's sarcoma and anogenital epithelial neoplasias.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Acquired Immunodeficiency Syndrome/*COMPLICATIONS Female Human *Lymphoma, AIDS-Related Male *Sarcoma, Kaposi *Urogenital NeoplasmsKWDjournalarticlereviewreview,tutorialacquiredimmunodeficiencysyndrome/KWDcomplicationsfemalehumanKWDlymphoma,aids-relatedmaleKWDsarcoma,kaposiKWDurogenitalneoplasms
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