Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas.

AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1199-203. Unique Identifier : AIDSLINE MED/98407609
Ellerbrok H; Fleischer C; Salemi M; Reinhardt P; Ludwig WD; Vandamme AM; Pauli G; Department of Virology, Robert Koch Institut, Berlin, Germany.

Abstract: In most parts of Europe only a limited number of sporadic cases of HTLV-I infections have been identified. So far, the few cases found in Germany have always been linked to individuals with relations to endemic areas. Here we report the first HTLV-I infection from a German ATL patient without any known risk for HTLV-I infection and with no relations to known endemic areas. The DNA sequence of the provirus was determined, and a phylogenetic analysis based on the LTR sequence established a close relationship with HTLV-I sequences previously found in two Romanian patients. Our data suggest the existence of a previously unrecognized cluster of HTLV-I infections in southeastern or central Europe.
Keywords: JOURNAL ARTICLE Adult Case Report DNA, Viral/ANALYSIS Female Germany/EPIDEMIOLOGY Human HTLV-I/*GENETICS/*ISOLATION & PURIF HTLV-I Infections/EPIDEMIOLOGY/*VIROLOGY Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/VIROLOGY Phylogeny Polymerase Chain Reaction/*METHODS Sequence Analysis, DNAKWDjournalarticleadultcasereportdna,viral/analysisfemalegermany/epidemiologyhumanhtlv-i/KWDgenetics/KWDisolation&purifhtlv-iinfections/epidemiology/KWDvirologyleukemia-lymphoma,t-cell,acute,htlv-i-associated/virologyphylogenypolymerasechainreaction/KWDmethodssequenceanalysis,dna
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A9920915

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