Association between a defective CCR-5 gene and progression to disease in HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Association between a defective CCR-5 gene and progression to disease in HIV infection.

AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1229-34. Unique Identifier : AIDSLINE MED/98435934
Balfe P; Churcher Y; Penny M; Easterbrook PJ; Goodall RL; Galpin S; Gotch F; Daniels RS; McKeating JA; Department of Virology, UCLMS, London, UK. p.balfe@ucl.ac.uk

Abstract: We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-5 delta32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 delta32 heterozygotes within the cohort compared with a control population of blood donors was observed. An association between progression rate and CCR-5 delta32 heterozygosity was observed. Furthermore, analysis of proviral DNA V3 sequences from a subset of the cohort predicted that the majority of individuals (39 of 44) were infected with viruses predicted to utilize the beta-chemokine receptor CCR-5. The marked association between CCR-5 genotype and disease progression observed in this study may be a consequence of the predicted low frequency of CXCR-4-utilizing viruses present within the selected cohort.
Keywords: JOURNAL ARTICLE Alleles Amino Acid Sequence Chemokines/BLOOD Cohort Studies Consensus Sequence Disease Progression Heterozygote Human HIV Antibodies/BLOOD HIV Envelope Protein gp120/GENETICS HIV Envelope Protein gp160/GENETICS HIV Infections/*GENETICS/IMMUNOLOGY/*PHYSIOPATHOLOGY *HIV Long-Term Survivors *HIV-1 Molecular Sequence Data Peptide Fragments/GENETICS Receptors, CCR5/*GENETICS/IMMUNOLOGY Support, Non-U.S. Gov't Time FactorsKWDjournalarticleallelesaminoacidsequencechemokines/bloodcohortstudiesconsensussequencediseaseprogressionheterozygotehumanhivantibodies/bloodhivenvelopeproteingp120/geneticshivenvelopeproteingp160/geneticshivinfections/KWDgenetics/immunology/KWDphysiopathologyKWDhivlong-termsurvivorsKWDhiv-1molecularsequencedatapeptidefragments/geneticsreceptors,ccr5/KWDgenetics/immunologysupport,non-uKWDsKWDgov'ttimefactors
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Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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