Case of the month: March 1999--A 26 year old HIV positive male with dura based masses. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.

Brain Pathol. 1999 Jul;9(3):609-10. Unique Identifier : AIDSLINE MED/99343440
Karpinski NC; Yaghmai R; Barba D; Hansen LA; Department of Pathology (Neuropathology), UCSD Medical Center,; San Diego, CA, USA.

Abstract: A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slender nuclei, consistent with leiomyomas. Both tumors were positive for Epstein Barr virus by in situ hybridization. This case report serves to emphasize the importance of considering soft tissue tumors such as leiomyoma in the differential diagnosis of mass lesions that occur in the central nervous system in AIDS and discusses the role of EBV in tumorigenesis.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Actins/METABOLISM Adult Brain Neoplasms/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGY Case Report Herpesvirus 4, Human/ISOLATION & PURIF Human Immunohistochemistry In Situ Hybridization Leiomyoma/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGY Magnetic Resonance Imaging Male Meningeal Neoplasms/*COMPLICATIONS/METABOLISM/PATHOLOGY/VIROLOGYKWDjournalarticleacquiredimmunodeficiencysyndrome/KWDcomplicationsactins/metabolismadultbrainneoplasms/KWDcomplications/metabolism/pathology/virologycasereportherpesvirus4,human/isolation&purifhumanimmunohistochemistryinsituhybridizationleiomyoma/KWDcomplications/metabolism/pathology/virologymagneticresonanceimagingmalemeningealneoplasms/KWDcomplications/metabolism/pathology/virology
991230
A99C1021

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .