Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier : AIDSLINE MED/99403447
Gottikh MB; Volkov EM; Romanova EA; Oretskaya TS; Shabarova ZA; A.N. Belozersky Institute of Physical Chemical Biology, Lomonosov; Moscow State University, Russia.

Abstract: This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5'- and/or 3'-terminal positions or one of the pyrimidine heterocyclic bases are developed.
Keywords: JOURNAL ARTICLE Base Sequence HIV Integrase Inhibitors/CHEMISTRY/*PHARMACOLOGY HIV Long Terminal Repeat HIV-1/*GENETICS Intercalating Agents/*CHEMISTRY Oligonucleotides/*CHEMISTRY Support, Non-U.S. Gov't Virus Integration/*DRUG EFFECTSKWDjournalarticlebasesequencehivintegraseinhibitors/chemistry/KWDpharmacologyhivlongterminalrepeathiv-1/KWDgeneticsintercalatingagents/KWDchemistryoligonucleotides/KWDchemistrysupport,non-uKWDsKWDgov'tvirusintegration/KWDdrugeffects
991230
A99C0993

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1999. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1999. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .