Binding of chemically-modified oligonucleotides to the double-stranded stem of an RNA hairpin. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Binding of chemically-modified oligonucleotides to the double-stranded stem of an RNA hairpin.

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1647-50. Unique Identifier : AIDSLINE MED/99403448
Aupeix K; Toulme JJ; INSERM U 386, IFR Pathologies Infectieuses, Universite Victor; Segalen, Bordeaux, France.

Abstract: We monitored the binding of triplex-forming oligopyrimidines to the double-stranded stem of the RNA hairpin responsible for the gag-pol frameshift in HIV-1. Whereas the substitution of 5, propynyl-C for C had a limited effect, the use of a Peptide Nucleic Acid 12mer led to a drastic reduction in the stability of the oligomer/RNA complex.
Keywords: JOURNAL ARTICLE Base Sequence Frameshifting, Ribosomal Fusion Proteins, gag-pol/GENETICS HIV-1/GENETICS *Nucleic Acid Conformation Oligonucleotides/*CHEMISTRY RNA, Double-Stranded/*CHEMISTRY RNA, Viral/CHEMISTRY Support, Non-U.S. Gov'tKWDjournalarticlebasesequenceframeshifting,ribosomalfusionproteins,gag-pol/geneticshiv-1/geneticsKWDnucleicacidconformationoligonucleotides/KWDchemistryrna,double-stranded/KWDchemistryrna,viral/chemistrysupport,non-uKWDsKWDgov't
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