Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides.

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1717-8. Unique Identifier : AIDSLINE MED/99403462
Brodin P; Gottikh M; Auclair C; Mouscadet JF; CNRS-UMR 1772, Institut Gustave Roussy, Villejuif, France.

Abstract: HIV-1 DNA integration is carried out by integrase, a viral protein which binds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations of mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which were designed to form an alternate strand triple helix with the U5 LTR end containing two adjacent purine tracts on opposite strands 5'-GGAAAATCTCT-3'/3'-CCTTTTAGAGA-5'.
Keywords: JOURNAL ARTICLE Base Sequence HIV Long Terminal Repeat HIV-1/*PHYSIOLOGY Oligonucleotides/*PHARMACOLOGY Support, Non-U.S. Gov't Virus Integration/*DRUG EFFECTSKWDjournalarticlebasesequencehivlongterminalrepeathiv-1/KWDphysiologyoligonucleotides/KWDpharmacologysupport,non-uKWDsKWDgov'tvirusintegration/KWDdrugeffects
991230
A99C0990

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