Manipulation of powder characteristics by interactions at the solid-liquid interface: 1-sulphadiazine. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Manipulation of powder characteristics by interactions at the solid-liquid interface: 1-sulphadiazine.

Eur J Pharm Sci. 1999 Aug;8(4):283-90. Unique Identifier : AIDSLINE MED/99356108
Hammouda YE; El-Khordagui LK; Darwish IA; El-Kamel AH; Department of Pharmaceutics, University of Alexandria,; Alexandria, Egypt.

Abstract: A solvent-treatment technique aiming at manipulating the properties of powdered materials is reported. Potentials of the technique were assessed using sulphadiazine (SD). A suspension of the drug in a preselected solvent (5% aqueous ammonia solution) was stirred under controlled conditions. The solvent was subsequently removed and the material dried. The effect of experimental variables such as stirring speed and time, powder/solvent ratio and inclusion of additives (Tween 80, sodium chloride and PVP) on the properties of solvent treated SD was assessed. Data obtained were compared with those for SD recrystallized under identical conditions. Solvent treatment of SD in the absence of additives resulted in a limited change in crystal morphology as indicated by SEM. This was associated with improved flowability and a limited reduction in dissolution rate relative to untreated SD. On the other hand, recrystallized SD exhibited superior flowability but a considerably low dissolution rate. Solvent treatment of SD in the presence of 2% PVP produced a microgranular directly compressible material.
Keywords: JOURNAL ARTICLE Anti-Infective Agents/*CHEMISTRY Chemistry, Pharmaceutical/*METHODS Pharmaceutic Aids/CHEMISTRY Polysorbates/CHEMISTRY Povidone/CHEMISTRY Powders/CHEMISTRY Sodium Chloride/CHEMISTRY Solutions Solvents Sulfadiazine/*CHEMISTRY Surface Properties Surface-Active Agents/CHEMISTRY Tablets/CHEMISTRYKWDjournalarticleanti-infectiveagents/KWDchemistrychemistry,pharmaceutical/KWDmethodspharmaceuticaids/chemistrypolysorbates/chemistrypovidone/chemistrypowders/chemistrysodiumchloride/chemistrysolutionssolventssulfadiazine/KWDchemistrysurfacepropertiessurface-activeagents/chemistrytablets/chemistry
991230
A99C0988

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