1999

Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid.: DNA Cell Biol. 1999 Sep;18(9):663-70. Unique Identifier : AIDSLINE MED/99420146; Feltquate DM; Robinson HL; Department of Pathology, University of Massachusetts Medical; School, Worcester, USA.; We previously showed that intramuscular saline DNA immunizations favor the development of an IgG2a-dominant Th1 immune response, whereas gene gun DNA immunizations stimulate the production of an IgG1-dominant Th2 immune response. Several studies have implicated immunostimulatory CpG sequences as the causative factor i
Dual activity of pyrrolidine dithiocarbamate on kappa B-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA.: Cell Signal. 1999 Jul;11(7):479-89. Unique Identifier : AIDSLINE MED/99334230; Watanabe K; Kazakova I; Furniss M; Miller SC; Signal Transduction Laboratory, SRI International, Menlo Park, CA; 94025, USA.; Pyrrolidine dithiocarbamate (PDTC) has been widely used as an inhibitor of the nuclear factor-kappa B, (NF-kappa B) signalling pathway. Here, we show that kappa B-dependent reporter gene expression induced by low concentrations of 12-O-tetradecanoylphorbol-13-acetate (TPA) is potentiated by PDTC in the human pro-monoc
Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome.: Pediatr Nephrol. 1999 Sep;13(7):586-93. Unique Identifier : AIDSLINE MED/99389603; Ray PE; Liu XH; Xu L; Rakusan T; Center IV, Room R-211, Children's Research Institute, Children's; National Medical Center, 111 Michigan Avenue N.W., Washington, DC; 20010, USA, Pray@cnmc.org; Endothelial injury is the primary pathogenic event leading to the renal thrombotic microangiopathic lesions typical of the hemolytic uremic syndrome (HUS). Basic fibroblast growth factor (bFGF) is an angiogenic growth factor released by injured endothelial cells. In a previous study we have found a significant accumul
The distinct role of CD4+ and CD8+ T-cells during the anti-tumour effects of targeted superantigens.: Br J Cancer. 1999 Sep;81(2):359-66. Unique Identifier : AIDSLINE MED/99424685; Litton MJ; Dohlsten M; Rosendahl A; Ohlsson L; Sogaard M; Andersson J; Andersson U; Department of Immunology, Wenner-Gren's Institute, Stockholm; University, Sweden.; To target T-cells to the tumour area we created a recombinant protein of the bacterial superantigen (SAg) Staphylococcal enterotoxin A (SEA) and the Fab-fragment of a tumour-reactive antibody. This antibody-targeted SAg immunotherapy therapy has been shown to be highly efficient, eliminating > 95% of the pulmonary met
Holistic care.: Nurs Stand. 1999 May 26-Jun 1;13(36):20. Unique Identifier : AIDSLINE MED/99427190; Snee T
The National HIV Nurses' Association.: Nurs Stand. 1999 Jun 9-15;13(38):31. Unique Identifier : AIDSLINE MED/99427119; Shaw T; Welsh L; Foundation of Nursing Studies, London. theresa.shaw@fons.org
T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients.: Schizophr Res. 1999 Jul 27;38(1):61-70. Unique Identifier : AIDSLINE MED/99356618; Sperner-Unterweger B; Whitworth A; Kemmler G; Hilbe W; Thaler J; Weiss G; Fleischhacker WW; Department of Biological Psychiatry, Innsbruck University; Clinics, Austria.; T-cell subsets (CD3+, CD4+, CD8+, NK-cells) and the CD4+/CD8+ ratio were measured in 56 schizophrenic patients admitted to hospital with an acute psychosis. Thirty-five patients with chronic schizophrenia and 21 drug-naive first episode schizophrenic patients were compared with 16 healthy controls. T-cell subsets were
An alternate pathway for type 1 T cell differentiation.: Int Immunol. 1999 Aug;11(8):1185-94. Unique Identifier : AIDSLINE MED/99352249; Feng C; Watanabe S; Maruyama S; Suzuki G; Sato M; Furuta T; Kojima S; Taki S; Asano Y; Department of Microbiology and Immunology, Ehime University; School of Medicine, Shigenobu, Ehime 791-0295, Japan.; IFN-regulatory factor-1 (IRF-1) gene-disrupted mice are defective in IL-12 and IL-18 gene expression at the transcriptional and post-translational level respectively. The mutant mouse mounts a type 2 T cell response upon bacterial infection because of the impaired induction of the IL-12 p40 gene and IFN-gamma-producin
A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes.: Int Immunol. 1999 Aug;11(8):1203-16. Unique Identifier : AIDSLINE MED/99352251; King LB; Tolosa E; Lenczowski JM; Lu F; Lind EF; Hunziker R; Petrie HT; Ashwell JD; Laboratory of Immune Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda MD 20892, USA.; While Jun/Fos-containing transcription factors are known to be necessary for many TCR-mediated events in mature T cells, relatively little is known about their roles in thymocyte development. We have generated transgenic mice that express a trans-dominant-negative mutant of c-Jun (TAM-67) specifically in thymocytes. E
Death by neglect as a deletional mechanism of peripheral tolerance.: Int Immunol. 1999 Aug;11(8):1225-38. Unique Identifier : AIDSLINE MED/99352253; Bertolino P; Trescol-Biemont MC; Thomas J; de St Groth BF; Pihlgren M; Marvel J; Rabourdin-Combe C; Ecole Normale Superieure de Lyon, INSERM U98, 46 Allee; d'Italie, 69364 Lyon Cedex 07, France.; In contrast to most organs, the anatomy of the liver may allow naive CD8(+) T cells to make direct contact with liver parenchymal cells. We have previously shown, using a combination of TCR transgenic T cells specific for H-2 K(b) and hepatocytes expressing a transgenic H-2 K(b) molecule, that hepatocytes can induce a
Autoimmunity to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype.: Int Immunol. 1999 Aug;11(8):1307-12. Unique Identifier : AIDSLINE MED/99352261; Sun B; Sun SH; Chan CC; Wiggert B; Caspi RR; Laboratory of Immunology, and Laboratory of Retinal Cell and; Molecular Biology, National Eye Institute, NIH, Bethesda, MD; 20892, USA.; Susceptible, but not resistant, strains of rodents immunized for induction of experimental autoimmune uveitis (EAU) with the uveitogenic protein interphotoreceptor retinoid-binding protein (IRBP) exhibit a type 1 response at the time of disease expression. Here we investigate the evolution of this response using the p
Peripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression.: Int Immunol. 1999 Aug;11(8):1327-36. Unique Identifier : AIDSLINE MED/99352263; Labalette M; Leteurtre E; Thumerelle C; Grutzmacher C; Tourvieille B; Dessaint JP; Service d'Immunologie, EA 2686, Centre Hospitalier et; Universitaire de Lille, 59045 Lille, France.; At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-)
Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset.: Unique Identifier : AIDSLINE MED/99352264; Perrin G; Schnuriger V; Quiquerez AL; Saas P; Pannetier C; de Tribolet N; Tiercy JM; Aubry JP; Dietrich PY; Walker PR; Laboratory of Tumor Immunology, Division of Oncology, University; Hospital, 1211 Geneva 14, Switzerland.; Anaplastic astrocytoma and glioblastoma are frequent and malignant brain tumors that are infiltrated by T lymphocytes. Whether these cells result from non-specific inflammation following blood-brain barrier disruption or an antigen-driven specific immune response is unknown. In this study, an in-depth characterization
HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes.: Int Immunol. 1999 Aug;11(8):1351-6. Unique Identifier : AIDSLINE MED/99352265; Le Gal FA; Riteau B; Sedlik C; Khalil-Daher I; Menier C; Dausset J; Guillet JG; Carosella ED; Rouas-Freiss N; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM U445, Institut Cochin de Genetique; Moleculaire, 27, rue du Faubourg St Jacques, Universite Rene; Descartes, 75014 Paris, France.; In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8(+) T cells specific for the influenza vi
Effect of nonpolar substitutions of the conserved Phe11 in the fusion peptide of HIV-1 gp41 on its function, structure, and organization in membranes.: Biochemistry. 1999 Aug 31;38(35):11359-71. Unique Identifier : AIDSLINE MED/99400476; Pritsker M; Rucker J; Hoffman TL; Doms RW; Shai Y; Department of Biological Chemistry, Weizmann Institute of; Science, Rehovot, Israel.; The fusion domain of the HIV-1 envelope glycoprotein (gp120-gp41) is a conserved hydrophobic region located at the N-terminus of the transmembrane subunit (gp41). A prominent feature of this domain is a conserved five-residue FLGFL sequence at positions 8-12. Mutation of the highly conserved Phe(11) to Val (F11V), p
Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro.: Biochemistry. 1999 Aug 31;38(35):11501-7. Unique Identifier : AIDSLINE MED/99400492; Hayakawa N; Nozawa K; Ogawa A; Kato N; Yoshida K; Akamatsu Ki; Tsuchiya M; Nagasaka A; Yoshida S; Department of Internal Medicine, Fujita Health University School; of Medicine, Toyoake, Aichi, Japan.; The telomere hypothesis postulates stabilization of telomere length and telomerase activation as key events in cellular immortalization and carcinogeneses. Accordingly, telomerase has been suggested as a novel and highly selective target for design of antitumor drugs. Screening of a chemical library including 16 000 s
Lung allograft dysfunction correlates with gamma-interferon gene expression in bronchoalveolar lavage.: J Heart Lung Transplant. 1999 Jul;18(7):627-36. Unique Identifier : AIDSLINE MED/99379407; Ross DJ; Moudgil A; Bagga A; Toyoda M; Marchevsky AM; Kass RM; Jordan SC; Division of Pulmonary and Critical Care Medicine, Cedars-Sinai; Medical Center Lung and Heart-Lung Transplant Program, Los; Angeles, California, USA. ROSS-D@CSMC.EDU; BACKGROUND: Preceding episodes of acute cellular rejection (ACR) may predispose lung allografts to the subsequent development of irreversible dysfunction or bronchiolitis obliterans syndrome (BOS). Other histologic patterns such as bronchiolitis obliterans with organizing pneumonia (BOOP), organizing pneumonia, lympho
Changing attitudes towards antiretroviral treatment of HIV infection: a prospective study in a sample of Dutch general practitioners.: AIDS Care. 1999 Apr;11(2):141-5. Unique Identifier : AIDSLINE MED/99403865; Reedijk M; Bindels PJ; Mohrs J; Wigersma L; Department of General Practice, Academic Medical Centre,; University of Amsterdam, The Netherlands.; This study investigated the attitude towards antiretroviral therapy (ART) for HIV infection over time, in a sample of Dutch general practitioners (GPs). Twenty-one GPs, of which 16 were practising in Amsterdam, completed multiple questionnaires on HIV-related topics between April 1995 and March 1997. In 1995, only 10%
Use of protease inhibitors among persons with AIDS in Los Angeles County.: AIDS Care. 1999 Apr;11(2):147-55. Unique Identifier : AIDSLINE MED/99403866; Sorvillo F; Kerndt P; Odem S; Castillon M; Carruth A; Contreras R; Los Angeles County Department of Health Services, HIV; Epidemiology Program, California 90005, USA.; sorv100w@wonder.em.cdc.gov; We evaluated the access to, and the factors associated with, protease inhibitor use among persons with AIDS in Los Angeles County. A population-based sample of adult persons with AIDS is routinely interviewed in Los Angeles County and includes a 30% random sample of men who have sex with men and all other persons repo
AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownership.: AIDS Care. 1999 Apr;11(2):157-70. Unique Identifier : AIDSLINE MED/99403867; Siegel JM; Angulo FJ; Detels R; Wesch J; Mullen A; University of California, Los Angeles, USA. jmsiegel@ucla.edu; The impact of pet ownership on depression was tested among a sample of gay and bisexual men (n = 1,872). Multivariate analyses, controlling for demographics and baseline depressive symptomatology, showed that neither pet ownership nor the presence of HIV infection was associated with depression. Depression was influen
Measuring the stress associated with caring for clients with HIV/AIDS.: AIDS Care. 1999 Apr;11(2):171-80. Unique Identifier : AIDSLINE MED/99403868; Niven CA; Knussen C; Department of Nursing and Midwifery, University of Stirling, UK.; The AIDS-stress scale (Pleck et al., 1988) provides measures of the sources of stress faced by health care workers caring for people with AIDS. The aim of the study was to consider the utility of the scale as a means of identifying groups of health care workers who would benefit from intervention. Data were collected
Heterosexual couples confronting the challenges of HIV infection.: AIDS Care. 1999 Apr;11(2):181-93. Unique Identifier : AIDSLINE MED/99403869; VanDevanter N; Thacker AS; Bass G; Arnold M; Columbia University School of Public Health, Division of; Sociomedical Sciences, New York, NY 10032, USA. nlvl@columbia.edu; Couples confronted with HIV infection face significant challenges. Little is known about the impact of HIV on heterosexual couples who account for the vast majority of cases worldwide and an increasing proportion of cases in the USA, especially among women. In this study, analysis of data collected on HIV-discordant c
Women who are HIV infected: the role of religious activity in psychosocial adjustment.: AIDS Care. 1999 Apr;11(2):195-9. Unique Identifier : AIDSLINE MED/99403870; Biggar H; Forehand R; Devine D; Brody G; Armistead L; Morse E; Simon P; Institute for Behavioral Research, University of Georgia, Athens; 30602, USA.; The role of religious activity in the psychosocial adjustment of 205 inner-city African-American women, one-half of whom are HIV infected, was examined. Those who were HIV infected reported praying more but viewed prayer as less effective in coping with a chronic illness. Frequency of prayer predicted optimism about t
'In an important way, I did die': uncertainty and revival in persons living with HIV or AIDS.: AIDS Care. 1999 Apr;11(2):201-19. Unique Identifier : AIDSLINE MED/99403871; Brashers DE; Neidig JL; Cardillo LW; Dobbs LK; Russell JA; Haas SM; Department of Speech Communication, University of Illinois,; Urbana 61801-3631, USA. dbrasher@uiuc.edu; This study reports the revival experiences of persons who once were reconciled to their death from HIV/AIDS but who, as a result of dramatic treatment responses, now believe they may survive (popularly known as the Lazarus Syndrome). A purposive sample of men and women living with HIV infection or AIDS were interviewe
Parallel accounts? Discrepancies between self-report (diary) and recall (questionnaire) measures of the same sexual behaviour.: AIDS Care. 1999 Apr;11(2):221-34. Unique Identifier : AIDSLINE MED/99403872; Coxon AP; University of Essex, Colchester, UK. apmc@essex.ac.uk; Questionnaires and diaries have complementary biases and advantages for obtaining information on sexual behaviour but self-completed sexual diaries have the advantage of reducing retrospective bias. In a validation study of homosexual behaviour, sexual diary counts and subsequent questionnaire estimates (together with
Nature and consequences of stressful life events in homosexual HIV-positive men: a review.: Unique Identifier : AIDSLINE MED/99403873; Nott KH; Vedhara K; Department of Psychology, University Newcastle upon Tyne, UK.; A great deal of research has been conducted into the stressful experiences that befall HIV-infected individuals. In this review we have focused on the work that has been conducted with HIV-positive homosexual males and have examined issues concerning the measurement, nature and consequences of stressful life events. I
UNAIDS/WHO global AIDS statistics.: AIDS Care. 1999 Apr;11(2):253-64. Unique Identifier : AIDSLINE MED/99403874
HIV risk behaviours of current sex workers attending syringe exchange: the experiences of women in five US cities.: AIDS Care. 1999 Jun;11(3):269-80. Unique Identifier : AIDSLINE MED/99403875; Paone D; Cooper H; Alperen J; Shi Q; Des Jarlais DC; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA.; Existing research indicates that sex workers who inject drugs are vulnerable to HIV infection through both risky sexual and drug use practices. This study is the first attempt to learn whether this increased risk persists among current sex workers who participate in syringe exchange programmes (SEPs). With data from i
Factors associated with gay men's sexual behaviours and risk on holiday.: AIDS Care. 1999 Jun;11(3):281-95. Unique Identifier : AIDSLINE MED/99403876; Clift SM; Forrest SP; Centre for Health Education and Research, Canterbury Christ; Church University College, UK. s.m.clift@cant.ac.uk; Findings are presented from a questionnaire survey of 562 gay men resident in southern England on their sexual behaviour in the context of holidays. Data were gathered during summer 1996 by means of a self-completion questionnaire; 395 men reported at least one holiday undertaken in 1996 and the analysis focuses on th
HIV risk behaviours among male-to-female transgenders in comparison with homosexual or bisexual males and heterosexual females.: Unique Identifier : AIDSLINE MED/99403877; Nemoto T; Luke D
Social support and unsupportive social interactions: their association with depression among people living with HIV.: AIDS Care. 1999 Jun;11(3):313-29. Unique Identifier : AIDSLINE MED/99403878; Ingram KM; Jones DA; Fass RJ; Neidig JL; Song YS; Department of Psychology, Virginia Commonwealth University,; Richmond 23284-2018, USA. kingram@saturn.vcu.edu; Although numerous studies of people living with HIV have focused on positive social support, researchers have directed surprisingly little attention to the nature and effects of negative social interactions in this population. Based on data from a diverse sample of people with HIV (N = 271), we conducted a factor anal
Patient satisfaction with HIV service provision in NPMS hospitals: the development of a standard satisfaction questionnaire. NPMS Steering Group.: AIDS Care. 1999 Jun;11(3):331-43. Unique Identifier : AIDSLINE MED/99403879; Beck EJ; Griffith R; Fitzpatrick R; Mandalia S; Carrier J; Conlon C; Mandel B; Ong E; Pozniak A; Tang A; Tomlinson D; Williams I; Department of Epidemiology and Public Health, Imperial College; School of Medicine, (Chelsea and Westminster Hospital), London,; UK. e.beck@ic.ac.uk; A self-completion satisfaction questionnaire evaluating the standard of care of HIV outpatient services was developed as part of the National Prospective Monitoring System on the Use, Cost and Outcome of HIV Service Provision in English Hospitals (NPMS). The questionnaire was designed in conjunction with service users
Use of chart reminders for physicians to promote discussion of advance directives in patients with AIDS.: AIDS Care. 1999 Jun;11(3):345-53. Unique Identifier : AIDSLINE MED/99403880; Walker NM; Mandell KL; Tsevat J; Department of Internal Medicine, University of Cincinnati Medical; Center, Ohio 45267-0535, USA.; To determine if use of a physician chart reminder improves the rate of physician-initiated discussion and subsequent completion of advance directives (ADs) in patients with AIDS, a controlled study was conducted with 74 patients with AIDS and ten physicians providing primary care at a university-based hospital clinic.
Reluctance amongst nurses and doctors to care for and treat patients with HIV/AIDS.: AIDS Care. 1999 Jun;11(3):355-9. Unique Identifier : AIDSLINE MED/99403881; McCann TV; Faculty of Nursing, University of Newcastle, Callaghan, New South; Wales, Australia. vntm@cc.newcastle.edu.au; A survey was carried out, using a questionnaire and semi-structured interviews, to examine why nurses and doctors might be reluctant to care for patients with HIV/AIDS. The findings provided four main themes: perceptions about sexual promiscuity; blaming certain patients with HIV/AIDS; belief in the right to refuse to
Predictors of outpatient medical appointment attendance among persons with HIV.: AIDS Care. 1999 Jun;11(3):361-73. Unique Identifier : AIDSLINE MED/99403882; Catz SL; McClure JB; Jones GN; Brantley PJ; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Milwaukee 53202, USA.; Non-adherence to medical regimens is a critical threat to the health of HIV-infected individuals. Patients who do not adhere to routine medical care cannot fully benefit from the increasingly efficacious treatments available to them. Consistent attendance at medical appointments plays a central role in both prolonging
Young people and HIV in Cambodia: meanings, contexts and sexual cultures.: Unique Identifier : AIDSLINE MED/99403883; Tarr CM; Aggleton P; University of Phnom Penh, Cambodia. Choumeng@camnet.com.kh; Like many other countries in South East Asia, Cambodia is experiencing a rapidly developing AIDS epidemic. Groups reported as being particularly seriously affected include sex workers and their clients. Young people too may be at heightened risk: some young women find sex work a
Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) lipid conjugates as steric barrier molecules in liposomal formulations.: Bioconjug Chem. 1999 Jul-Aug;10(4):653-66. Unique Identifier : AIDSLINE MED/99339826; Ansell SM; Kojic LD; Hankins JS; Sekirov L; Boey A; Lee DK; Bennett AR; Klimuk SK; Harasym TO; Santos ND; Semple SC; Inex Pharmaceuticals Corp., 100-8900 Glenlyon Parkway, Burnaby,; B.C., V5J 5J8, Canada. sansell@inexpharm.com; Lipid conjugates of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) (ATTAn) were synthesized as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives used in liposomal drug delivery systems. The new lipids were shown to be at least equivalent to MePEGA-2000-DSPE in assays designed to evaluate the effe
Overexpression of Fas/CD95 and Fas-induced apoptosis in a patient with idiopathic CD4+ T lymphocytopenia.: Unique Identifier : AIDSLINE MED/99379696; Roger PM; Bernard-Pomier G; Counillon E; Breittmayer JP; Bernard A
Evolution of vaginal Candida species recovered from human immunodeficiency virus-infected women receiving fluconazole prophylaxis: the emergence of Candida glabrata? Terry Beirn Community Programs for Clinical Research in AIDS (CPCRA).: Clin Infect Dis. 1999 May;28(5):1025-31. Unique Identifier : AIDSLINE MED/99379698; Vazquez JA; Sobel JD; Peng G; Steele-Moore L; Schuman P; Holloway W; Neaton JD; Division of Infectious Diseases, Wayne State University School of; Medicine, Detroit, Michigan, USA. jvazquez@oncgate.roc.wayne.edu; The effect of fluconazole prophylaxis on the vaginal flora of 323 human immunodeficiency virus-infected women was evaluated in a multicenter, randomized, double-blind, placebo-controlled trial. Women with CD4 cell counts of
Chronic active hepatitis B exacerbations in human immunodeficiency virus-infected patients following development of resistance to or withdrawal of lamivudine.: Clin Infect Dis. 1999 May;28(5):1032-5. Unique Identifier : AIDSLINE MED/99379699; Bessesen M; Ives D; Condreay L; Lawrence S; Sherman KE; Department of Medicine, University of Colorado Health Sciences; Center, Denver, USA. mary.bessesen@med.va.gov; Lamivudine is a nucleoside analog with activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Patients coinfected with HIV and HBV may have hepatitis flares when lamivudine therapy is discontinued or when resistance of HBV to
Interferon gamma (IFN-gamma) deficiency in generalized Epstein-Barr virus infection with interstitial lymphoid and granulomatous pneumonia, focal cerebral lesions, and genital ulcers: remission following IFN-gamma substitution therapy.: Clin Infect Dis. 1999 May;28(5):1036-42. Unique Identifier : AIDSLINE MED/99379700; Andersson J; Isberg B; Christensson B; Veress B; Linde A; Bratel T; Department of Infectious Diseases, Karolinska Institutet,; Huddinge University Hospital, Stockholm, Sweden.; jan.andersson@infect.hs.sll.se; A 26-year-old previously healthy woman developed granulomatous pneumonitis, encephalitis, and genital ulceration during primary Epstein-Barr virus (EBV) infection. EBV DNA was demonstrated by polymerase chain reaction analysis of serum, lung tissue, and genital ulcer specimens. Serology verified primary EBV infection.
Itraconazole prophylaxis for fungal infections in patients with advanced human immunodeficiency virus infection: randomized, placebo-controlled, double-blind study. National Institute of Allergy and Infectious Diseases Mycoses Study Group.: Unique Identifier : AIDSLINE MED/99379702; McKinsey DS; Wheat LJ; Cloud GA; Pierce M; Black JR; Bamberger DM; Goldman M
A randomized, placebo-controlled study of rifabutin added to a regimen of clarithromycin and ethambutol for treatment of disseminated infection with Mycobacterium avium complex.: Clin Infect Dis. 1999 May;28(5):1080-5. Unique Identifier : AIDSLINE MED/99379707; Gordin FM; Sullam PM; Shafran SD; Cohn DL; Wynne B; Paxton L; Perry K; Horsburgh CR Jr; Veterans Affairs Medical Center and Georgetown University,; Washington, DC, USA.; Current guidelines suggest that disseminated Mycobacterium avium complex (MAC) infection be treated with a macrolide plus ethambutol or rifabutin or both. From 1993 to 1996, 198 AIDS patients with MAC bacteremia participated in a prospective, placebo-controlled trial of clarithromycin (500 mg b.i.d.) plus ethambutol (
Genital ulcers: etiology, clinical diagnosis, and associated human immunodeficiency virus infection in Kingston, Jamaica.: Clin Infect Dis. 1999 May;28(5):1086-90. Unique Identifier : AIDSLINE MED/99379708; Behets FM; Brathwaite AR; Hylton-Kong T; Chen CY; Hoffman I; Weiss JB; Morse SA; Dallabetta G; Cohen MS; Figueroa JP; Department of Medicine, University of North Carolina at Chapel; Hill, USA. BehetsF@aol.com; Individuals presenting consecutively with genital ulcers in Kingston, Jamaica , underwent serological testing for human immunodeficiency virus (HIV) infection, chlamydial infection, and syphilis. Ulcer material was analyzed by multiplex polymerase chain reaction (M-PCR) analysis. D
Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 May;28(5):1095-9. Unique Identifier : AIDSLINE MED/99379710; Dworkin MS; Sullivan PS; Buskin SE; Harrington RD; Olliffe J; MacArthur RD; Lopez CE; Centers for Disease Control and Prevention, National Center for; HIV, STD and TB Prevention, Division of HIV/AIDS; Prevention-Surveillance and Epidemiology, Atlanta, Georgia 30333,; USA. mdd3@cdc.gov; Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in dogs. We identified nine human immunodeficiency virus (HIV)-infected persons with culture-confirmed B. bronchiseptica infections (eight respiratory tract and one disseminated infection). The resp
Treatment of human immunodeficiency virus 1-infected infants and children with the protease inhibitor nelfinavir mesylate.: Clin Infect Dis. 1999 May;28(5):1109-18. Unique Identifier : AIDSLINE MED/99379713; Krogstad P; Wiznia A; Luzuriaga K; Dankner W; Nielsen K; Gersten M; Kerr B; Hendricks A; Boczany B; Rosenberg M; Jung D; Spector SA; Bryson Y; Department of Pediatrics, UCLA, Los Angeles, California,; 90095-3075, USA. pkrogsta@pediatrics.medsch.ucla.edu; An open-label study was conducted of nelfinavir mesylate, given with reverse transcriptase inhibitors to human immunodeficiency virus 1 (HIV-1)-infected infants and children 3 months to 13 years of age. Doses of nelfinavir mesylate of 20-30 mg/kg yielded drug exposures comparable to those seen in adults. The drug was
Progressive multifocal leukoencephalopathy in patients with AIDS receiving highly active antiretroviral therapy.: Clin Infect Dis. 1999 May;28(5):1152-4. Unique Identifier : AIDSLINE MED/99379720; Tantisiriwat W; Tebas P; Clifford DB; Powderly WG; Fichtenbaum CJ; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63108, USA.; Recent reports suggest that human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML) may improve with highly active antiretroviral therapy (HAART). We observed three patients who developed PML while receiving HAART. All patients received HAART for 4-11 months and had low plasma le
Pneumocystis carinii pneumonia mimicking Wegener's granulomatosis.: Clin Infect Dis. 1999 May;28(5):1163-4. Unique Identifier : AIDSLINE MED/99379725; Evans RH; Gelder CM; Smith AP; Freedman AR; Department of Medicine and Infectious Diseases, University; Hospital of Wales, Cardiff.
Two episodes of acute renal failure, rhabdomyolysis, and severe hepatitis in an AIDS patient successively treated with ritonavir and indinavir.: Clin Infect Dis. 1999 May;28(5):1180-1. Unique Identifier : AIDSLINE MED/99379737; Benveniste O; Longuet P; Duval X; Le Moing V; Leport C; Vilde JL; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris, France.; olivier.benveniste@psl.ap-hop-paris.fr
Prospective follow-up of 67 indinavir-experienced human immunodeficiency virus-infected and AIDS patients treated with the ritonavir/saquinavir combination.: Clin Infect Dis. 1999 May;28(5):1184-5. Unique Identifier : AIDSLINE MED/99379741; Lallemand F; Adda N; Schneider V; Jacomet C; Salhi Y; Rozenbaum W; Department of Infectious Diseases, Hospital Rothschild, Paris,; France.
Tropical infectious diseases in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 May;28(5):947-63; quiz 964-5. Unique Identifier : AIDSLINE MED/99379688; Karp CL; Neva FA; Department of Medicine, Johns Hopkins University Schools of; Medicine, and Hygiene and Public Health, Baltimore, Maryland; 21205, USA. ckarp@welchlink.welch.jhu.edu
Acetylator phenotype prevalence in HIV-infected patients without previous trimethoprim-sulfamethoxazole hypersensitivity [letter]: Biomed Pharmacother. 1999 Jun;53(5-6):286-7. Unique Identifier : AIDSLINE MED/99353097; Quirino T; Bonfanti P; Arcidiacono M; Pusterla L; Cagni A; Scaglione F; Milazzo F; This trial was conducted to study the frequency of the slow acetylator phenotype in asymptomatic HIV patients having no previous reaction to sulfa-drugs, and to compare this frequency with the frequency found in healthy controls. Results show that HIV alone is not capable of modifying the acetylator phenotype; the pre
Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance.: Blood. 1999 Sep 1;94(5):1590-600. Unique Identifier : AIDSLINE MED/99409031; Chelucci C; Casella I; Federico M; Testa U; Macioce G; Pelosi E; Guerriero R; Mariani G; Giampaolo A; Hassan HJ; Peschle C; Departments of Hematology-Oncology and Virology, Istituto; Superiore di Sanita, Rome, Italy; and Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, PA 19107-5541, USA.; Human immunodeficiency virus (HIV) entry is mediated not only by the CD4 receptor, but also by interaction with closely related molecules that act as membrane coreceptors. We have analyzed mRNA expression and/or cell membrane exposition of the coreceptors most widely used by diverse HIV-1 strains (CXCR4, CCR5, and CCR
Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells.: Blood. 1999 Sep 1;94(5):1747-54. Unique Identifier : AIDSLINE MED/99409047; Chirivi RG; Taraboletti G; Bani MR; Barra L; Piccinini G; Giacca M; Bussolino F; Giavazzi R; Laboratory of the Biology and Treatment of Metastasis, Mario; Negri Institute for Pharmacological Research, Bergamo, Italy.; Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-
Sensitivity of CD4+ peripheral blood T cells toward spontaneous and CD95 (APO-1/Fas)-induced apoptosis in pediatric human immunodeficiency virus infection [letter]: Blood. 1999 Sep 1;94(5):1829-33. Unique Identifier : AIDSLINE MED/99433224; Bohler T; Debatin KM; Linde R
[Cytogenic characteristics and virogenic status of lymphoid cells from malignant baboon lymphomas]: Vestn Ross Akad Med Nauk. 1999;(7):49-53. Unique Identifier : AIDSLINE MED/99397217; Agrba VZ; Medvedeva NM; Iakovleva LA; Chikobava MG; Araviashvili DE; Timanovskaia VV; Lapin BA; Four lymphoid cell cultures obtained from Papio hamadryads with malignant lymphomas were studied. The cultured cells produced two lymphotropic EBV-like herpes virus of Papio (HVP) and T-lymphotropic monkey retrovirus STLV-1 (HTLV-1 family) or HVP alone. More than 100 subcultured cell lines were shown to remain mixed B
Southern Africa's 'Holocaust': is HIV infection uncontrollable?: Natl Med J India. 1999 May-Jun;12(3):132-3. Unique Identifier : AIDSLINE MED/99422260; Walker AR
Increasing seroprevalence of HIV among high-risk hospitalized patients in Mumbai [letter]: Natl Med J India. 1999 May-Jun;12(3):139-40. Unique Identifier : AIDSLINE MED/99422264; Kamat HA; Koppikar GV; Banker DD
Persistent infection with human T lymphotropic virus type 1 after allogeneic bone marrow transplantation from a seronegative donor [letter]: Bone Marrow Transplant. 1999 Aug;24(3):349. Unique Identifier : AIDSLINE MED/99394753; Kanda Y; Taketazu F; Chiba S; Yazaki Y; Hirai H
Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression.: Lupus. 1999;8(5):384-7. Unique Identifier : AIDSLINE MED/99394769; Huber SA; Kupperman J; Newell MK; Department of Pathology, University of Vermont, Burlington 05405,; USA.; Coxsackievirus B3 (CVB3) induces myocarditis in male BALB/c mice. Female mice are resistant to viral myocarditis, except in the third trimester of pregnancy and postpartum. Cardiac damage is mediated by T lymphocytes activated during virus infection. Th1 (interferon-gamma+) cell responses promote cardiac injury, while
[Tracing infants born to HIV positive mothers (letter)]: Arch Pediatr. 1999 Aug;6(8):902-3. Unique Identifier : AIDSLINE MED/99401628; Herve F; Chaux MC; Smail A; Dollfus C; Courpotin C
An autopsy case of primary nodal plasmacytoma associated with Sjogren's syndrome [letter]: Pathol Int. 1999 Jun;49(6):577-9. Unique Identifier : AIDSLINE MED/99398193; Watanabe K; Yatabe Y; Narita M; Ogawa T; Mori N; An 81-year-old man with a 1 year history of Sjogren s syndrome and hypergammaglobulinemic purpura was admitted because of high fever and lymphadenopathy. Primary nodal plasmacytoma was suggested from the microscopic and immunohistochemical findings of an inguinal lymph node biopsy specimen. Although chemotherapy achie
Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA.: Brain Pathol. 1999 Jul;9(3):481-93. Unique Identifier : AIDSLINE MED/99343431; Tsunoda I; Tolley ND; Theil DJ; Whitton JL; Kobayashi H; Fujinami RS; Department of Neurology, University of Utah School of Medicine,; Salt Lake City 84132, USA.; Theiler s murine encephalomyelitis virus (TMEV) infection and relapsing-remitting experimental allergic encephalomyelitis (R-EAE) have been used to investigate the viral and autoimmune etiology of multiple sclerosis (MS), a possible Th1-type mediated disease. DNA immunization is a novel vaccination strategy in which f
Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.: Brain Pathol. 1999 Jul;9(3):609-10. Unique Identifier : AIDSLINE MED/99343440; Karpinski NC; Yaghmai R; Barba D; Hansen LA; Department of Pathology (Neuropathology), UCSD Medical Center,; San Diego, CA, USA.; A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slend
Diagnosis of esophageal ulcers in acquired immunodeficiency syndrome.: Semin Gastrointest Dis. 1999 Jul;10(3):85-92. Unique Identifier : AIDSLINE MED/99362048; Monkemuller KE; Wilcox CM; Department of Medicine, University of Alabama at Birmingham,; 35294-0007, USA.; The esophagus is one of the most common sites of gastrointestinal involvement in human immunodeficiency virus (HIV)-infected patients, with at least 30% of the patients having esophageal symptoms at some point during the course of HIV infection. Esophageal ulcers are commonly caused by infections such as
The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.: J Mol Med. 1999 Jun;77(6):495-504. Unique Identifier : AIDSLINE MED/99402049; Hinuma S; Onda H; Fujino M; Discovery Research Division, Takeda Chemical Industries, Ltd.,; Tsukuba, Ibaraki, Japan. Hinuma_Shuji@takeda.co.jp; Various sorts of bioactive molecules including hormones, neurotransmitters, and chemokines transmit signals into cells by binding to so-called seven-transmembrane-domain receptors (7TMRs). The recent progress in cDNA and genome DNA analyses has brought the discovery of numerous genes encoding ligand-unknown orphan 7
Chemokine gene expression in human oral mucosa.: Eur J Oral Sci. 1999 Aug;107(4):231-5. Unique Identifier : AIDSLINE MED/99396013; Zehnder M; Greenspan JS; Greenspan D; Bickel M; Department of Removable Prosthodontics, School of Dental; Medicine, University of Bern, Switzerland.; In order to gain further understanding of the role of chemokines in healthy oral mucosa, we analyzed mRNA expression of the alpha (CXC)-family chemokines IL-8 and GROgamma as well as of the beta (CC)-family chemokines MIP-1alpha, MIP-1beta and MCP-1 in twenty young and healthy subjects with good oral hygiene. Twenty b
Control of cytomegalovirus retinitis after combination antiretroviral therapy.: Acta Ophthalmol Scand. 1999 Aug;77(4):471-3. Unique Identifier : AIDSLINE MED/99391067; Ruhswurm I; Ries E; Krepler K; Derbolav A; Rieger A; Armbruster C; Wedrich A; Department of Ophthalmology, University of Vienna, Medical; School, Austria.; PURPOSE: To report on AIDS patients having combination antiretroviral therapy whose cytomegalovirus ( CMV ) retinitis remained inactive after discontinuation of anti-CMV maintenance therapy. METHODS: We describe the course of C
Emergency department characteristics of male sexual assault.: Acad Emerg Med. 1999 Aug;6(8):792-8. Unique Identifier : AIDSLINE MED/99391191; Pesola GR; Westfal RE; Kuffner CA; Department of Emergency Medicine, Saint Vincent's Hospital, New; York, NY 10011, USA.; OBJECTIVE: To characterize the nature, frequency, and treatment of male sexual assault encountered by physicians in an ED. A minor objective compared the lengths of time the victim knew the assailant between males and females to determine whether there were differences between male and female victims. METHODS: Retrosp
Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women.: Nat Med. 1999 Sep;5(9):1004-9. Unique Identifier : AIDSLINE MED/99401079; Wang Y; Tao L; Mitchell E; Bravery C; Berlingieri P; Armstrong P; Vaughan R; Underwood J; Lehner T; Department of Immunobiology, Guy's, King's and St. Thomas'; Medical and Dental Schools at Guy's Hospital, Medical School; Building, 3rd Floor, London SE1 9RT, UK.; We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of CD8 cell-derived suppr
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library [see comments]: Nat Med. 1999 Sep;5(9):1026-31. Unique Identifier : AIDSLINE MED/99401082; Wong FS; Karttunen J; Dumont C; Wen L; Visintin I; Pilip IM; Shastri N; Pamer EG; Janeway CA Jr; Section of Immunobiology, Yale School of Medicine, 310 Cedar; Street, New Haven, Connecticut 06520-8011, USA.; susan.wong@yale.edu; Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed at an early age by an immune process that involves both CD4 and CD8 T lymphocytes. The identification of autoantigens in diabetes is very important for the design of antigen-specific immunotherapy. By screening
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells.: Nat Med. 1999 Sep;5(9):1039-43. Unique Identifier : AIDSLINE MED/99401084; Tomazin R; Boname J; Hegde NR; Lewinsohn DM; Altschuler Y; Jones TR; Cresswell P; Nelson JA; Riddell SR; Johnson DC; Department of Molecular Microbiology & Immunology, Oregon Health; Sciences University, Portland, Oregon 97201, USA.; Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes life-threatening disease in patients who are immunosuppressed for bone marrow or tissue transplantation or who have AIDS (ref. 1). HCMV establishes lifelong latent infections and, after periodic reactivation from
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.: Nat Med. 1999 Sep;5(9):1048-51. Unique Identifier : AIDSLINE MED/99401086; Schuetz JD; Connelly MC; Sun D; Paibir SG; Flynn PM; Srinivas RV; Kumar A; Fridland A; Department of Pharmaceutical Sciences, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; john.schuetz@stjude.org; Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART) (ref. 1). Six reverse transcriptase inhibitors have been approved for human use: azidothymidine; 2 3 -dideoxycytidine; 2 3 -dideoxyinosin
Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: applications for universal detection and quantitation.: Nat Med. 1999 Sep;5(9):1081-5. Unique Identifier : AIDSLINE MED/99401093; Lu W; Cao L; Ty L; Arlie M; Andrieu JM; Laboratoire d'Oncologie et Virologie Moleculaires, Hopital; Laennec, Faculte de Medecine Necker, Universite Rene; Descartes-Paris V, 75007 Paris, France.
Uganda gives lessons in stemming the AIDS epidemic [editorial]: Nat Med. 1999 Sep;5(9):963. Unique Identifier : AIDSLINE MED/99401044
HIV-1 Nef protein: An invitation to a kill [news; comment]: Nat Med. 1999 Sep;5(9):985-6. Unique Identifier : AIDSLINE MED/99401070; Cullen BR
Spotting a killer's target in autoimmune diabetes [news; comment]: Nat Med. 1999 Sep;5(9):992-3. Unique Identifier : AIDSLINE MED/99401075; Benoist C; Mathis D
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages [see comments]: Nat Med. 1999 Sep;5(9):997-103. Unique Identifier : AIDSLINE MED/99401078; Swingler S; Mann A; Jacque J; Brichacek B; Sasseville VG; Williams K; Lackner AA; Janoff EN; Wang R; Fisher D; Stevenson M; University of Massachusetts Medical Center, Program in Molecular; Medicine, 373 Plantation Street, Worcester, Massachusetts 01605,; USA.; Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to promote the infection of macrophages. Here we demonstrate that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory
A new look at hypersensitivity pneumonitis.: Curr Opin Pulm Med. 1999 Sep;5(5):299-304. Unique Identifier : AIDSLINE MED/99390635; Ando M; Suga M; Kohrogi H; First Department of Internal Medicine, Kumamoto University School; of Medicine, Japan.; Hypersensitivity pneumonitis is an immunologically induced lung disease. Although both immune complex-mediated immune response and T cell-mediated immune response are involved in the pathogenesis of the disease, recent studies show the latter mechanism to be more important. As for T cell-mediated immune response, Th1/
On down-regulation of the immune response to metastatic malignant melanoma.: Unique Identifier : AIDSLINE MED/99405747; H~akansson A; Gustafsson B; Krysander L; Hjelmqvist B; Rettrup B; H~akansson L; Department of Oncology, University Hospital, Linkoping, Sweden.; annika.hakansson@lio.se; Treatment of metastatic malignant melanoma with interferon alpha (IFNalpha) results in objective remission in approximately 15% of patients. In a previous investigation, we found that about 50% of the patients achieved at least minor or short-lived remissions. In some tumours extensive areas of regressive tumour chang
Immunoregulation in pancreatic cancer patients.: Cancer Immunol Immunother. 1999 Aug;48(5):270-9. Unique Identifier : AIDSLINE MED/99405749; Plate JM; Shott S; Harris JE; Section of Medical Oncology, Department of Medicine,; Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612,; USA. jplate@sispro.sis.rpslmc.edu; Metastatic pancreatic cancer is one of the most aggressive cancer known in man yet specific antitumor immunity has been demonstrated in lymph nodes draining the sites of pancreatic tumors. Despite this immunity, pancreatic cancer patients suffer a quick demise. To further define tumor immunity in patients with metasta
Punctate outer retinal toxoplasmosis in an HIV-positive child.: Ocul Immunol Inflamm. 1999 Jun;7(2):93-5. Unique Identifier : AIDSLINE MED/99350660; Moraes HV Jr; Federal University of Rio de Janeiro, University Hospital,; Department of Ophthalmology, Brazil Rio de Janeiro.; haroldjr@alternex.com.br; PURPOSE: To discover whether the outer layer of the retina can be the site for toxoplasmosis in AIDS patients. METHODS: An HIV-positive child, who previously had a normal ocular examination, was reexamined three months later. This examination showed outer retinal lesions compatible with toxoplasmosis and positive IgM
Cluster formation by protein kinase Ctheta during murine T cell activation: effect of age.: Cell Immunol. 1999 Jul 10;195(1):28-36. Unique Identifier : AIDSLINE MED/99365230; Yang D; Miller RA; Department of Pathology, University of Michigan, Ann Arbor,; Michigan, 48109-0940, USA.; Protein kinase Ctheta; (PKCtheta;) is thought to play an important role in T cell activation, in that exposure of cloned T cells to antigen-presenting cells bearing agonist peptides, but not antagonist peptides, leads to clustering of PKCtheta; molecules in the section of the T cell plasma membrane that is in contact
Bovine insulin and porcine or human insulin prime distinct CD4(+) T cell subsets in C57BL/6 mice.: Cell Immunol. 1999 Jul 10;195(1):66-74. Unique Identifier : AIDSLINE MED/99365234; Long SA; Zimecki M; Kapp JA; Department of Ophthalmology, Emory University, Atlanta, Georgia,; 30322, USA.; H-2(b) mice produce insulin-specific antibody when injected with bovine but not porcine or human insulin. Nevertheless, CD4(+) T cells have been cloned from C57BL/6 mice primed with porcine, human, and bovine insulin. Here we tested the hypothesis that CD4(+) T cells from C57BL/6 mice primed with porcine or human insu
Prevalence of sinonasal symptoms in patients with HIV infection.: Am J Rhinol. 1999 May-Jun;13(3):203-8. Unique Identifier : AIDSLINE MED/99320536; Porter JP; Patel AA; Dewey CM; Stewart MG; Bobby R. Alford Department of Otorhinolaryngology and; Communicative Sciences, Baylor College of Medicine, Houston,; Texas 77030, USA.; Infection with the human immunodeficiency virus (HIV) is increasing in prevalence, and disease patterns are changing as patient survival lengthens. The purpose of this cross-sectional epidemiological study was to assess the prevalence and severity of self-reported symptoms of otolaryngologic disease in a group of pati
Structural and functional characterization of an epitope in the conserved C-terminal region of HIV-1 gp120.: J Pept Res. 1999 Jul;54(1):32-42. Unique Identifier : AIDSLINE MED/99376198; Ferrer M; Sullivan BJ; Godbout KL; Burke E; Stump HS; Godoy J; Golden A; Profy AT; van Schravendijk MR; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, MA 02138, USA.; Through an integrated study of the reactivity of a monoclonal antibody, 803-15.6, with synthetic peptides and native recombinant HIV-1 envelope glycoprotein gp120, we have obtained structure-functional information on a region of rgp120 not yet elucidated by X-ray crystallography. mAb 803-15.6 binds with high affinity
Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets.: Biol Blood Marrow Transplant. 1999;5(3):123-32. Unique Identifier : AIDSLINE MED/99320129; Johnson BD; Becker EE; Truitt RL; Department of Pediatrics, Medical College of Wisconsin, Milwaukee; 53226, USA. bjohnson@mcw.edu; Infusions of donor leukocytes have been given to allogeneic bone marrow recipients after transplant to treat leukemia relapse. Treatment with these delayed infusions of donor cells has been called delayed or donor leukocyte infusion (DLI). While graft-vs.-host disease (GVHD) has typically been less severe than expecte
Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals.: Biol Blood Marrow Transplant. 1999;5(3):162-72. Unique Identifier : AIDSLINE MED/99320133; Banda NK; Simon GR; Sipple JD; Terrell KL; Archer P; Shpall EJ; Akkina RK; Myers AM; Harrison GS; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA. nirmal.banda@uchsc.edu; Pancytopenia as a consequence of bone marrow abnormalities is commonly seen in HIV-infected individuals. To examine the effect that HIV-1 has on hematopoietic cells, we compared hematopoietic properties of bone marrow samples from HTV+ patients at various stages of disease with bone marrow samples from uninfected dono
Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells.: Clin Cancer Res. 1999 Jun;5(6):1281-8. Unique Identifier : AIDSLINE MED/99316772; Chikamatsu K; Nakano K; Storkus WJ; Appella E; Lotze MT; Whiteside TL; DeLeo AB; University of Pittsburgh Cancer Institute, Pennsylvania 15213,; USA.; CTLs recognizing the HLA-A2.1-restricted, wild-type sequence p53 epitopes p53(149-157) and p53(264-272) were generated from CD8-enriched populations of nonadherent peripheral blood lymphocytes (PBLs) obtained from healthy donors. The PBLs were restimulated in vitro with peptide-pulsed granulocyte macrophage colony-sti
Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1221-2. Unique Identifier : AIDSLINE MED/99403425; Jamison J; Gilloteaux J; Nassiri MR; Tsai CC; Summers J; Department of Urology, Summa Health System/N.E. Ohio Universities; College of Medicine, Rootstown 44272, USA.; Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleola
Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1483-4. Unique Identifier : AIDSLINE MED/99403436; Kvasyuk EI; Mikhailopulo IA; Suhadolnik RJ; Henderson EE; Muto NF; Iacono KT; Homon J; Pfleiderer W; Institute of Bioorganic Chemistry, Byelorussian Academy of; Sciences, Minsk, Belarus.; Some new 2 ,5 -oligonucleotide trimers containing 5 -terminal 5 -amino-5 -deoxy- and 5 -amino-3 ,5 -dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.
Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier : AIDSLINE MED/99403447; Gottikh MB; Volkov EM; Romanova EA; Oretskaya TS; Shabarova ZA; A.N. Belozersky Institute of Physical Chemical Biology, Lomonosov; Moscow State University, Russia.; This investigation is devoted to design of short switch oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5 - and/or 3 -terminal positions or on
Binding of chemically-modified oligonucleotides to the double-stranded stem of an RNA hairpin.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1647-50. Unique Identifier : AIDSLINE MED/99403448; Aupeix K; Toulme JJ; INSERM U 386, IFR Pathologies Infectieuses, Universite Victor; Segalen, Bordeaux, France.; We monitored the binding of triplex-forming oligopyrimidines to the double-stranded stem of the RNA hairpin responsible for the gag-pol frameshift in HIV-1. Whereas the substitution of 5, propynyl-C for C had a limited effect, the use of a Peptide Nucleic Acid 12mer led to a drastic reduction in the stability of the o
Antisense oligodeoxynucleotide complementary to CXCR4 mRNA block replication of HIV-1 in COS cells.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1705-8. Unique Identifier : AIDSLINE MED/99403459; Kusunoki A; Wada A; Kurosaki N; Kimura T; Takai K; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.; CXCR4 is both a chemokine receptor and an entry co-receptor for the T-cell line-adapted human immunodeficiency virus type 1 (HIV-1). To find a more efficacious therapeutic treatment of acquired immunodeficiency syndrome, we examined the effects of antisense oligonucleotides on CXCR4 production. COS cells, stably expre
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1717-8. Unique Identifier : AIDSLINE MED/99403462; Brodin P; Gottikh M; Auclair C; Mouscadet JF; CNRS-UMR 1772, Institut Gustave Roussy, Villejuif, France.; HIV-1 DNA integration is carried out by integrase, a viral protein which binds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations of mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which were designed to form
Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method.: Eur J Pharm Sci. 1999 Aug;8(4):269-81. Unique Identifier : AIDSLINE MED/99356107; Wulff M; Alden M; Department of Pharmaceutical Chemistry, Physical and Inorganic; Chemistry, Box 574, Biomedical Center, Uppsala University, S-751; 23, Uppsala, Sweden.; The melting method was investigated as a possible method for producing drug-cyclodextrin (CD) inclusion compounds in a carrier. Various solid dispersions of alpha-, beta- and gamma-CD in polyethylene glycol (PEG) 6000 with and without the addition of 5% w/w indomethacin or griseofulvin were prepared using the original
Manipulation of powder characteristics by interactions at the solid-liquid interface: 1-sulphadiazine.: Eur J Pharm Sci. 1999 Aug;8(4):283-90. Unique Identifier : AIDSLINE MED/99356108; Hammouda YE; El-Khordagui LK; Darwish IA; El-Kamel AH; Department of Pharmaceutics, University of Alexandria,; Alexandria, Egypt.; A solvent-treatment technique aiming at manipulating the properties of powdered materials is reported. Potentials of the technique were assessed using sulphadiazine (SD). A suspension of the drug in a preselected solvent (5% aqueous ammonia solution) was stirred under controlled conditions. The solvent was subsequentl
Correlation of anti-HIV activity with structure: use of electrostatic potential and conformational analysis.: Bioorg Med Chem Lett. 1999 Jul 19;9(14):1963-8. Unique Identifier : AIDSLINE MED/99378172; Mickle T; Nair V; Department of Chemistry, The University of Iowa, Iowa City 52242,; USA.; Electrostatic potential distribution, 3-D electron density shapes, and conformational analysis were used to correlate anti-HIV activity or inactivity of AZT , (-) carbovir, oxetanocin A, and 16 isomeric dideoxynucleosides of different families. The str
4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.: Bioorg Med Chem Lett. 1999 Jul 19;9(14):2019-24. Unique Identifier : AIDSLINE MED/99378182; Ellsworth EL; Domagala J; Prasad JV; Hagen S; Ferguson D; Holler T; Hupe D; Graham N; Nouhan C; Tummino PJ; Zeikus G; Lunney EA; Department of Chemistry, Parke-Davis Pharmaceutical Research; Division of the Warner-Lambert Company, Ann Arbor, MI 48105, USA.; 5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1 , and S2 pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S1 and S2 pockets have provide
Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia.: Cancer Chemother Pharmacol. 1999;44(4):303-6. Unique Identifier : AIDSLINE MED/99376759; Lopez AM; Wallace L; Dorr RT; Koff M; Hersh EM; Alberts DS; Department of Medicine, College of Medicine, University of; Arizona, Tucson, AZ 85724, USA.; PURPOSE: Chemotherapeutic regimens that utilize fluorouracil, cytarabine, and doxorubicin have been shown to cause a dermatologic syndrome known as hand-foot syndrome, or palmar-plantar erythrodysesthesia syndrome (PPES). Pegylated liposomal doxorubicin has proven effective in the treatment of AIDS-related Kaposi s sa
[Long-term effect of lamivudine treatment in chronic hepatitis B virus infection]: Unique Identifier : AIDSLINE MED/99418037; Yao G; Wang B
[Recent advance in neuroimmunology]: Rinsho Shinkeigaku. 1998 Dec;38(12):993-6. Unique Identifier : AIDSLINE MED/99278953; Arimura K; Osame M; 3rd Department of Interna Medicine, Faculty of Medicine,; Kagoshima University.; Many important reports have been published during these several years in Japan in the field of neuroimmunology. Serum vascular endothelial factor (VEGF) levels in Crow-Fukase (POEMS) syndrome were about 15 to 30 times than those in the control subjects and other neurological disorde
[A case of limbic encephalitis associated with breast cancer developed in an HTLV-1 carrier]: Rinsho Shinkeigaku. 1999 May;39(5):555-9. Unique Identifier : AIDSLINE MED/99352948; Kikuchi A; Chida K; Misu T; Okita N; Takase S; Nagata T; Sakai K; Itoyama Y; Department of Neurology, Kohnan Hospital.; We here present a case of 44-year-old woman, a carrier of human T-lymphotrophic virus type-1 (HTLV-1), who suffered from limbic encephalitis and breast cancer. In December 1997, the patient s behavior became abnormal. Three weeks later, she became markedly forgetful. At that time neurological examinations revealed tha
Mediastinal lymphadenitis due to cryptococcal infection in HIV-positive patients on highly active antiretroviral therapy [letter]: Chest. 1999 Sep;116(3):848-9. Unique Identifier : AIDSLINE MED/99420058; Lanzafame M; Trevenzoli M; Carretta G; Lazzarini L; Vento S; Concia E
Prospective study of healing time after hemorrhoidectomy: influence of HIV infection, acquired immunodeficiency syndrome, and anal wound infection.: Dis Colon Rectum. 1999 Sep;42(9):1140-4. Unique Identifier : AIDSLINE MED/99424872; Morandi E; Merlini D; Salvaggio A; Foschi D; Trabucchi E; I Department of Surgery, Institute of Biomedical Science L.; Sacco, University of Milan, Italy.; PURPOSE: Hemorrhoids and rectal diseases are very frequent in HIV-positive patients, especially in those with homosexual habits. This study was designed to compare posthemorrhoidectomy healing time in such patients, and evaluate the role of various factors related to their HIV-positive status. METHODS: The study invol
Changing epidemiology of anorectal melanoma.: Dis Colon Rectum. 1999 Sep;42(9):1203-8. Unique Identifier : AIDSLINE MED/99424882; Cagir B; Whiteford MH; Topham A; Rakinic J; Fry RD; Department of Surgery, Jefferson Medical College, Thomas; Jefferson University Hospital, Philadelphia, Pennsylvania 19107,; USA.; PURPOSE: We reviewed 117 cases of anorectal melanoma to better define epidemiologic and survival characteristics of this rare neoplasm. METHODS: The National Cancer Institute Surveillance, Epidemiology, and End Results database covering the period 1973 through 1992 was used. This represents 9.5 percent of the
Nutritional status of adult inpatients in Bujumbura, Burundi (impact of HIV infection).: Eur J Clin Nutr. 1999 Jul;53(7):579-82. Unique Identifier : AIDSLINE MED/99379482; Niyongabo T; Henzel D; Ndayishimyie JM; Melchior JC; Ndayiragije A; Ndihokubwayo JB; Nikoyagize E; Rwasa T; Aubry P; Larouze B; Departement de Medecine Interne, CHU de Bujumbura, Burundi.; OBJECTIVE: To determine the prevalence and analyse the characteristics and causes of malnutrition among inpatients in an HIV highly endemic area. DESIGN: Prospective cross-sectional study. SETTING: Department of Internal Medicine, University Hospital, Bujumbura, Burundi . SUBJECTS:
Rare AIDS-defining diseases in the Swiss HIV Cohort Study.: Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):399-402. Unique Identifier : AIDSLINE MED/99369020; Burckhardt B; Sendi P; Pfluger D; Zimmerli W; Nuesch R; Bucher HC; Drewe J; Gyr N; Battegay M; Outpatient Department of Internal Medicine, University of Basel,; Switzerland.; The objective of this study was to investigate the spectrum and frequency of rare AIDS-defining diseases in the Swiss HIV Cohort Study. AIDS-defining diseases contributing less than 1% to the absolute number of all recorded AIDS-defining diseases in at least one of five periods (1988-1990, 1991-1992, 1993-1994, 1995-1
Usefulness of genotypic analysis of resistance to nucleoside analogues in the clinical setting.: Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):448-9. Unique Identifier : AIDSLINE MED/99369030; Perez-Olmeda M; Rodriguez-Rosado R; Gomez-Cano M; Briones C; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.; The introduction of drug resistance testing during clinical care of patients infected with the human immunodeficiency virus (HIV) is still a matter for discussion. Thirty-seven HIV-infected subjects who had positive plasma viraemia despite undergoing antiretroviral therapy were tested for the presence of genotypic mut
Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia.: Eur J Pharmacol. 1999 Jun 18;374(2):309-13. Unique Identifier : AIDSLINE MED/99349635; Boddeke EW; Meigel I; Frentzel S; Biber K; Renn LQ; Gebicke-Harter P; Department of Medical Physiology, University of Groningen,; Netherlands. h.w.g.m.boddeke@med.rug.nl; Functional expression of CX3CR1, a recently discovered receptor for the chemokine fractalkine, was investigated in cultured rat microglia. Reverse transcriptase polymerase chain reaction (PCR) experiments show abundant expression of fractalkine receptor mRNA in microglia. mRNA expression of fractalkine was undetectabl
Simulation studies of phase III clinical trials to test the efficacy of a candidate HIV-1 vaccine.: Epidemiol Infect. 1999 Aug;123(1):65-88. Unique Identifier : AIDSLINE MED/99415584; Desai KN; Boily MC; Masse BR; Alary M; Anderson RM; CHA-Pavillon St-Sacrement, Groupe de recherche en; epidemiologie, Quebec, Quebec, Canada.; One question of particular importance in phase III HIV vaccine trials is the choice of efficacy measure (EM) to validly and precisely estimate the true vaccinal efficacy. Traditional EMs, based on hazard rate ratio (HRR) or cumulative incidence ratio (CIR) are time-sensitive to mode of vaccine action and population he
Risk factors for monoinfections and coinfections with HIV, hepatitis B and hepatitis C viruses in northern Spanish prisoners.: Epidemiol Infect. 1999 Aug;123(1):95-102. Unique Identifier : AIDSLINE MED/99415586; Pallas J; Farinas-Alvarez C; Prieto D; Llorca J; Delgado-Rodriguez M; Provincial Prison, Santander, Spain.; A cross-sectional study was conducted in prisons of Cantabria (northern Spain ) from June 1992 to December 1994. Inmates were asked to participate in a survey on prevalence and risk factors for monoinfections and coinfections with HIV, HBV and HCV. Crude and multiple odds ratios of r
Parentification and its impact on adolescent children of parents with AIDS.: Fam Process. 1999 Summer;38(2):193-208. Unique Identifier : AIDSLINE MED/99336058; Stein JA; Riedel M; Rotheram-Borus MJ; Department of Psychology, University of California, Los Angeles; 90095-1563, USA. jastein@ucla.edu; Parentification refers to children or adolescents assuming adult roles before they are emotionally or developmentally ready to manage those roles successfully. We assess predictors and outcomes of parentification among adolescent children of Parents with AIDS (PWAs) in two phases. In Phase 1, relationships among paren
Seroprevalence of syphilis, human immunodeficiency virus type-1, and hepatitis B virus infections among pregnant women in Turkey.: Int J Gynaecol Obstet. 1999 Aug;66(2):171-2. Unique Identifier : AIDSLINE MED/99396418; Nas T; Taner MZ; Yildiz A; Gazi University Hospital, Besevler, Ankara, Turkey.
Human immunodeficiency virus infection in pregnant women in Nigeria.: Int J Gynaecol Obstet. 1999 Aug;66(2):183-4. Unique Identifier : AIDSLINE MED/99396423; Sagay AS; Imade GE; Nwokedi EE; Department of Obstetrics and Gynaecology, Jos University Teaching; Hospital, Nigeria. sagays@unijos.edu.ng
Onset of type 1 diabetes: a dynamical instability.: Diabetes. 1999 Sep;48(9):1677-85. Unique Identifier : AIDSLINE MED/99408471; Freiesleben De Blasio B; Bak P; Pociot F; Karlsen AE; Nerup J; Niels Bohr Institute, Copenhagen, Denmark.; Type 1 diabetes is a disease characterized by progressive loss of beta-cell function due to an autoimmune reaction affecting the islets of Langerhans. It is now generally accepted that cytokines are implicated in the pathogenesis of autoimmune diseases. Animal studies have shown that interleukin-1beta, tumor necrosis
Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.: Diabetes. 1999 Sep;48(9):1713-9. Unique Identifier : AIDSLINE MED/99408476; Murray AG; Nelson RC; Rayat GR; Elliott JF; Korbutt GS; Department of Medicine, University of Alberta, Edmonton, Canada.; amurray@mercury.uah.ualberta.ca; Xenotransplantation of porcine tissue to human recipients promises to alleviate the organ shortage. Human antibody-mediated and cell-mediated immune responses against porcine grafts, however, represent barriers to successful xenotransplantation. We compared neonatal porcine islet cells (NPICs) and neonatal porcine spl
Protection against HIV infection for medical trainees outside the United States.: Fam Med. 1999 Jul-Aug;31(7):495-500. Unique Identifier : AIDSLINE MED/99354263; Markle WH; Department of Family Medicine and Clinical Epidemiology,; University of Pittsburgh, USA. whm@mars.upmc.edu; BACKGROUND AND OBJECTIVES: The increase in HIV infection rates around the world has created concern among medical educators for the safety of students and residents taking overseas electives. In some areas, the HIV adult positivity rate is 15%-20% or higher. Medical schools and residency programs need to make policies
Clinical application of adoptive immunotherapy and IL-2 for the treatment of advanced digestive tract cancer.: Hepatogastroenterology. 1999 May;46 Suppl 1:1274-9. Unique Identifier : AIDSLINE MED/99357043; Ueda Y; Yamagishi H; Tanioka Y; Fujiwara H; Fuji N; Itoh T; Fujiki H; Yoshimura T; Oka T; Second Department of Surgery, Kyoto Prefectural University of; Medicine, Japan.; BACKGROUND/AIMS: We investigated the clinical efficacy of systemic and locoregional adoptive immunotherapy (AIT) with or without interleukin-2 ( IL-2 ) against solid metastatic lesions from digestive tract cancer, which are refractory to conventional chemotherapy or radi
Enteric pathogens in southern Indian HIV-infected patients with & without diarrhoea.: Indian J Med Res. 1999 Mar;109:85-9. Unique Identifier : AIDSLINE MED/99419587; Mukhopadhya A; Ramakrishna BS; Kang G; Pulimood AB; Mathan MM; Zachariah A; Mathai DC; Wellcome Trust Research Laboratory, Department of; Gastrointestinal Sciences, Christian Medical College Hospital,; Vellore.; This study was undertaken to determine the carriage rate of various enteric pathogens in southern Indian patients with HIV infection, both with and without diarrhoea. Stool from 111 consecutive HIV-positive patients (50 without and 61 with diarrhoea) was examined by microscopy and culture. Jejunal biopsy and fluid exa
Repetition of the mother-infant dyad and the process of dying in the psychotherapy of an HIV-positive man.: J Am Acad Psychoanal. 1999 Summer;27(2):191-203. Unique Identifier : AIDSLINE MED/99390719; Des Rosiers P; McGill University, Department of Psychiatry.
A new potent HIV-1 reverse transcriptase inhibitor. A synthetic peptide derived from the interface subunit domains.: J Biol Chem. 1999 Aug 27;274(35):24941-6. Unique Identifier : AIDSLINE MED/99386978; Morris MC; Robert-Hebmann V; Chaloin L; Mery J; Heitz F; Devaux C; Goody RS; Divita G; Biophysics Department, Centre de Recherches de Biochimie; Macromoleculaire, CNRS, 1919 Route de Mende, 34283 Montpellier,; Cedex 5, France.; The biologically relevant and active forms of human immunodeficiency viruses type 1 and 2 reverse transcriptase found in infectious virions are heterodimers produced in a two-step dimerization process. Dimerization involves first the rapid association of the two subunits, followed by a slow conformational change yield
Self-association of Puralpha is mediated by RNA.: J Cell Biochem. 1999 Sep 1;74(3):334-48. Unique Identifier : AIDSLINE MED/99341941; Gallia GL; Darbinian N; Johnson EM; Khalili K; Center for NeuroVirology and NeuroOncology, MCP Hahnemann; University, Philadelphia, Pennsylvania 19102, USA.; The 322 amino acid cellular protein, Puralpha, is a sequence-specific single-stranded DNA-binding protein implicated in control of transcription and replication. Previous studies have demonstrated that the interaction between Puralpha and its target DNA sequence results in the formation of multimeric complexes. In thi
Detection of dendritic cells in the non-obese diabetic (NOD) mouse islet pancreas infiltrate is correlated with Th2-cytokine production.: J Cell Biochem. 1999 Sep 1;74(3):447-57. Unique Identifier : AIDSLINE MED/99341950; Papaccio G; De Luca A; De Luca B; Pisanti FA; Zarrilli S; Institute of Histology and Embryology, School of Medicine, Second; University of Naples, 80138 Naples, Italy. gpapacc@tin.it; We investigate the role played by dendritic cells (DCs) in the non-obese diabetic (NOD) mouse pancreas. The early peri-islet, nondestructive infiltration phase, and intra-islet, destructive infiltration phase, which immediately precedes overt diabetes, are studied. Results show that infiltrating cells are Ia-b, ICAM-1
American Academy of Dermatology 1999 Awards for Young Investigators in Dermatology. Active transcription of human herpesvirus 8 cellular homologue genes and HIV-1 tat in various forms of Kaposi's sarcoma.: J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):458-9. Unique Identifier : AIDSLINE MED/99430845; Moore AY; The University of Texas Medical Branch at Galveston, USA.
Striae formation in two HIV-positive persons receiving protease inhibitors.: J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):467-9. Unique Identifier : AIDSLINE MED/99389770; Darvay A; Acland K; Lynn W; Russell-Jones R; Department of Dermatology, Ealing Hospital, London, United; Kingdom.; Steroidal side effects such as buffalo hump and visceral abdominal fat accumulation have been reported in association with protease inhibitors . We report two cases of severe disfiguring striae formation in patients with HIV who recently started
Oral candidiasis in children with immune suppression: clinical appearance and therapeutic considerations.: ASDC J Dent Child. 1999 May-Jun;66(3):161-6, 154. Unique Identifier : AIDSLINE MED/99405268; Flaitz CM; Hicks MJ; Department of Stomatology, University of Texas-Houston Health; Science Center, USA.; Children and adolescents with immune compromise and suppression are particularly susceptible to the development of oral candidiasis. In fact, oral candidiasis is the most common oral manifestation in HIV-infected children. Oral candidiasis has been linked to a depressed immune system, more rapid progression to AIDS, m
The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease.: J Am Coll Cardiol. 1999 Sep;34(3):857-65. Unique Identifier : AIDSLINE MED/99411771; Bowles NE; Kearney DL; Ni J; Perez-Atayde AR; Kline MW; Bricker JT; Ayres NA; Lipshultz SE; Shearer WT; Towbin JA; Department of Pediatrics, Baylor College of Medicine, Houston,; Texas 77030, USA.; OBJECTIVES: The aim of this study was to investigate the frequency of viral nucleic acid detection in the myocardium of human immunodeficiency virus (HIV)-infected children to determine whether an association exists with the development of heart disease. BACKGROUND: As improved medical interventions increase the life
Nevirapine-induced cutaneous hypersensitivity reactions and successful tolerance induction.: J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):504-5. Unique Identifier : AIDSLINE MED/99382355; Demoly P; Messaad D; Fabre J; Reynes J; Bousquet J; Department of Maladies Respiratoires, Institut National de la; Sante et de la Recherche Medicale U454-IFR3, Hopital Arnaud de; Villeneuve, and Centre Hospitalier Universitaire, Montpellier,; France.
Measurement of body composition in people with HIV/AIDS: a comparison of bioelectrical impedance and skinfold anthropometry with dual-energy x-ray absorptiometry.: J Am Diet Assoc. 1999 Sep;99(9):1109-11. Unique Identifier : AIDSLINE MED/99420513; Batterham MJ; Garsia R; Greenop P; Department of Nutrition and Dietetics, Royal Prince Alfred; Hospital, Camperdown, NSW, Australia.
[Orbital lymphoma and AIDS. Apropos of a case]: J Fr Ophtalmol. 1999 May;22(5):594-8. Unique Identifier : AIDSLINE MED/99346478; Than-Trong T; Morel X; D'Hermies F; Dighiero P; Le Tourneau A; Audouin J; Diebold J; Delmer A; Zittoun R; Renard G; Service d'ophtalmologie du Pr. Renard, Hotel Dieu, Paris.; We report the case of a 33-year-old HIV-seropositive male who had a large cell Epstein-Barr virus-associated non-Hodgkin s orbital lymphoma. A thorough medical examination enabled us to find on thoracic CT-scan a mediastinal lymph node involvement as large as 18 cm in diameter. The regression of the tumor was dramatic
The effects of HIV viral load on the phagocytic activity of monocytes activated with lipopolysaccharide from oral microorganisms.: Immunopharmacol Immunotoxicol. 1999 Aug;21(3):421-38. Unique Identifier : AIDSLINE MED/99395566; Baqui AA; Meiller TF; Zhang M; Falkler WA Jr; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore 21201, USA.; A study was undertaken to determine whether viral load status in HIV+ patients has any potential effect on monocyte phagocytic function both before and after challenge of the monocytes with lipopolysaccharide (LPS) isolated from oral microorganisms. LPS of two putative periodontal pathogens Porphyromonas gingivalis (P
[The disinfection of non-autoclavable hysteroscopes in gynecology. Proposition of a protocol and organization of its management]: J Gynecol Obstet Biol Reprod (Paris). 1999 Jul;28(4):381-3. Unique Identifier : AIDSLINE MED/99409439; Cravello L; Cailleux J; Roger V; Bretelle F; Blanc B; Service de Gynecologie-Obstetrique B, Hopital de la; Conception, Marseille.; Iatrogenic infections may result from diagnostic hysteroscopy in case of non autoclavable equipment (such as fibrohysteroscopes) and because of new infectious agents (such as HIV, hepatitis, ...). The equipment should be completely and thoroughly disinfected according to the manufacturer s instructions to prevent infe
The role of HBV DNA quantitative PCR in monitoring the response to interferon treatment in chronic hepatitis B virus infection.: J Hepatol. 1999 Jun;30(6):965-9. Unique Identifier : AIDSLINE MED/99332804; Nagata I; Colucci G; Gregorio GV; Cheeseman P; Williams R; Mieli-Vergani G; Vergani D; Institute of Hepatology, University College London Medical School; and Hospital, Denmark Hill, UK.; BACKGROUND/AIMS: To investigate whether the measurement of HBV DNA by quantitative polymerase chain reaction (PCR) is helpful in monitoring response to interferon treatment in chronic hepatitis B virus infection, we have determined sequentially serum levels of HBV DNA during and up to 18 months after treatment, in 10
Treatment of T lymphocytes with 8-methoxypsoralen plus ultraviolet A induces transient but biologically active Th1-skewing cytokine production.: J Invest Dermatol. 1999 Aug;113(2):202-8. Unique Identifier : AIDSLINE MED/99399290; Tokura Y; Seo N; Yagi H; Wakita H; Moriwaki S; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; 8-Methoxypsoralen plus ultraviolet A light is suggested to shift T lymphocytes from Th2 to Th1 cells. To clarify this issue, we examined the effects of 8-methoxypsoralen/ultraviolet A on the expression/production of cytokines in peripheral blood mononuclear cells from normal subjects and a Sezary syndrome patient. 8-M
[Evaluation of a new screening assay kit for the combined detection of HIV p24 antigen and antibody--comparison of the performance of the new kit and HIV antibody assay kits]: Kansenshogaku Zasshi. 1999 Jul;73(7):681-8. Unique Identifier : AIDSLINE MED/99411018; Hayashi T; Watanabe S; Kondo M; Saito T; Imai M; Department of Virology, Kanagawa Prefectural Public Health; Laboratory.; DUO is an automated HIV infection screening test kit based on the combined detection of p24 Ag and anti-HIV-1 and anti-HIV-2 IgG in human sera or plasma using the ELFA technique (Enzyme-Linked Fluorescent Assay). The performance of DUO was compared with that of HIV-1/HIV-2 3rd generation EIA plus and particle agglutin
[Granular lymphocyte-proliferative disorder following initiation of protease inhibitor therapy in a patient with acquired immunodeficiency syndrome]: Kansenshogaku Zasshi. 1999 Jul;73(7):702-6. Unique Identifier : AIDSLINE MED/99411021; Tanaka K; Honda J; Shiraishi K; Jojima H; Tanaka M; Okubo Y; Fukahori S; Fujimatsu Y; Oizumi K; First Department of Internal Medicine, Kurume University School; of Medicine.; The authors experienced granular lymphocyte-proliferative disorder (GLPD) with increased lymphocyte and CD4 cell counts after HIV treatment with a protease inhibitor indinavir in a 51-year-old male AIDS patient. GLPD proved to be the chronic type, but
Co-expression of a trans-dominant negative mutant of the human immunodeficiency virus type 1 (HIV-1) Rev protein affects the Rev-dependent splicing pattern and expression of HIV-1 RNAs.: J Gen Virol. 1999 Aug;80 ( Pt 8):1965-74. Unique Identifier : AIDSLINE MED/99394668; Szilvay AM; Boe SO; Kalland KH; Department of Molecular Biology, The Gade Institute, University; of Bergen, Norway. Anne.Szilvay@mbi.uib.no; Trans-dominant negative mutants of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev inhibit the function of wild-type Rev in a dose-dependent manner. This was previously shown to be caused by nuclear retention of the wild-type protein. In the present work, further analysis of the trans-dominant n
Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells.: J Gen Virol. 1999 Aug;80 ( Pt 8):1975-82. Unique Identifier : AIDSLINE MED/99394669; Dumonceaux J; Chanel C; Valente S; Quivet L; Briand P; Hazan U; INSERM Unite 380 Laboratoire de Genetique et Pathologie; Experimentales, Institut Cochin de Genetique Moleculaire,; Paris, France.; A previous report from this laboratory described the isolation of the first CD4-independent human immunodeficiency virus type 1 isolate, m7NDK. This independence of CD4 is due to seven mutations located in the C2, V3 and C3 regions of the gp120 protein. The present report describes the entry features of the m5NDK viru
Manganese cations increase the mutation rate of human immunodeficiency virus type 1 ex vivo.: J Gen Virol. 1999 Aug;80 ( Pt 8):1983-6. Unique Identifier : AIDSLINE MED/99394670; Vartanian JP; Sala M; Henry M; Wain-Hobson S; Meyerhans A; Institut Pasteur, Unite de Retrovirologie Moleculaire, Paris,; France. jpvart@pasteur.fr; Human immunodeficiency virus (HIV) reverse transcription is an error-prone process with an overall mutation rate of approximately 3.4 x 10(-5) per base per replication cycle. This rate can be modulated by changes in different components of the retrotranscription reaction. In particular, in vitro substitution of magnes
Human neutralizing human immunodeficiency virus type 2-specific Fab molecules generated by phage display.: J Gen Virol. 1999 Aug;80 ( Pt 8):1987-93. Unique Identifier : AIDSLINE MED/99394671; Bjorling E; von Garrelts E; Morner A; Ehnlund M; Persson MA; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden. ewa.bjorling@mtc.ki.se; A panel of human immunodeficiency virus type 2 (HIV-2)-neutralizing, recombinant Fab fragments was generated by using the phage display technique. The combinatorial library was derived from an asymptomatic, HIV-2-seropositive individual and constructed on the surface of filamentous phage by using the pComb3 phagemid v
Identification and phylogenetic characterization of a human T-cell leukaemia virus type I isolate from a native inhabitant (Rapa Nui) of Easter Island.: J Gen Virol. 1999 Aug;80 ( Pt 8):1995-2001. Unique Identifier : AIDSLINE GENBANK/AF132300; Ohkura S; Yamashita M; Cartier L; Tanabe DG; Hayami M; Sonoda S; Tajima K; Laboratory of Viral Pathogenesis, Research Center for AIDS,; Institute for Virus Research, Kyoto University, Japan.; Human T-cell leukaemia virus type I (HTLV-I) is endemic in Melanesia, one of the three ethnogeographic regions of the Pacific; in the other two regions, Polynesia and Micronesia , the incidence of the virus is relatively low. In an e
Herpes simplex virus type 1 infection has two separate modes of spread in three-dimensional keratinocyte culture.: J Gen Virol. 1999 Aug;80 ( Pt 8):2149-55. Unique Identifier : AIDSLINE MED/99394690; Hukkanen V; Mikola H; Nykanen M; Syrjanen S; Department of Virology, University of Turku, Finland.; This study describes the outcome of herpes simplex virus type 1 (HSV-1) infection in an organotypic raft culture of spontaneously immortalized HaCat keratinocytes and human fibroblasts, as related to the virus load and epithelial stratification and differentiation. In this model, a confluent monolayer of HaCat keratin
Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor.: J Gen Virol. 1999 Aug;80 ( Pt 8):2205-9. Unique Identifier : AIDSLINE MED/99394696; Roan F; Zimring JC; Goodbourn S; Offermann MK; Winship Cancer Center, Emory University, Atlanta, GA 30322, USA.; Human herpesvirus-8 (HHV-8), a gammaherpesvirus that is thought to be the viral aetiologic agent of Kaposi s sarcoma and primary effusion lymphoma, encodes a homologue to cellular interferon regulatory factors (IRFs). The HHV-8 IRF homologue (vIRF; ORF K9) has previously been shown to inhibit gene induction by interfe
A comparison of HIV/AIDS knowledge among high school freshmen and senior students.: J Community Health Nurs. 1999;16(3):151-63. Unique Identifier : AIDSLINE MED/99407947; Hancock T; Mikhail BI; Santos A; Nguyen A; Nguyen H; Bright D; Kern Medical Center, Bakersfield, California, USA.; Statistical data show that heterosexual transmission of AIDS among teenagers is a significant problem. The purpose of this study was to assess and compare the level of knowledge concerning HIV/AIDS among high school freshmen- and senior-level students and to determine the association between certain demographic variab
Influence of antimicrobial treatment on mortality in septicemia.: J Chemother. 1999 Jun;11(3):179-86. Unique Identifier : AIDSLINE MED/99362031; Behrendt G; Schneider S; Brodt HR; Just-Nubling G; Shah PM; Department of Medicine, Universitatsklinikum, Frankfurt am Main,; Germany.; OBJECTIVE: To determine the influence of antimicrobial therapy and of predisposing illness on the septicemia mortality rate. METHOD: All blood-culture-positive episodes of septicemia in the Department of Medicine at the University Hospital in Frankfurt between 1989 and 1993 were entered on a database. Underlying illne
Cytomegalovirus antigenemia surveillance in the treatment of cytomegalovirus disease in AIDS patients.: J Chemother. 1999 Jun;11(3):195-202. Unique Identifier : AIDSLINE MED/99362034; Carton JA; Rodriguez-Guardado A; Melon S; Maradona JA; De Ona M; Asensi V; Infectious Diseases Department, Hospital Central de Asturias,; Universidad de Oviedo, Spain.; OBJECTIVE: Surveillance of quantitative cytomegalovirus ( CMV ) antigenemia among AIDS patients with CMV treated complications in order to determine its value in assessing the response to treatment and survival. METHODS: A long
Successful treatment of cytomegalovirus colitis with ganciclovir in a patient with adult T cell leukemia lymphoma: case report.: J Chemother. 1999 Jun;11(3):215-9. Unique Identifier : AIDSLINE MED/99362038; Oshima Y; Nishida K; Kawazoye S; Noda T; Arima F; Miyahara M; Higashijima M; Yanaga T; Department of Hematology, Takagi Hospital, Ohkawa-city, Fukuoka,; Japan. oshima@i.kyushu-u.ac.jp; An 84-year-old patient with adult T cell leukemia lymphoma (ATLL) developed diarrhea on day 5 of chemotherapy and was diagnosed with cytomegalovirus ( CMV ) colitis. Sigmoidoscopy revealed multiple superficial erosions surround
Gastric and gingival localization of mucosa-associated lymphoid tissue (MALT) lymphoma. An immunohistochemical, virological and clinical case report.: J Periodontol. 1999 Aug;70(8):914-8. Unique Identifier : AIDSLINE MED/99404551; Margiotta V; Franco V; Rizzo A; Porter S; Scully C; Di Alberti L; Department of Oral Medicine, University of Palermo, Italy.; vamargio@tin.it; Non-Hodgkin s lymphomas (NHL) of the mucosa-associated lymphoid tissue (MALT) are characterized by their mucosal and glandular tissue localization. The case described here falls into the European-American classification of a low-grade B-cell lymphoma of the MALT type, with a gingival lesion 2 years after a gastric les
Telomere dynamics in monkeys: increased cell turnover in macaques infected with chimeric simian-human immunodeficiency viruses.: J Med Primatol. 1999 Feb;28(1):1-10. Unique Identifier : AIDSLINE MED/99299750; Shibata R; Feng YR; Gee D; Norwood D; Xiao X; Zeichner SL; Martin MA; Dimitrov DS; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.; To address the question of how cell turnover is affected by retroviral infections, we used the telomeric terminal restriction fragments (TRFs) as markers of cell replicative history and measured their length in macaques infected with chimeric simian-human immunodeficiency viruses (SHIVs). The TRF lengths of mononuclea
Solution structure of the capsid protein from the human T-cell leukemia virus type-I.: J Mol Biol. 1999 Aug 13;291(2):491-505. Unique Identifier : AIDSLINE PDB/1QRJ; Khorasanizadeh S; Campos-Olivas R; Summers MF; Howard Hughes Medical Institute and Department of Chemistry and; Biochemistry, University of Maryland Baltimore County, Baltimore,; MD, 21250, USA.; The solution structure of the capsid protein (CA) from the human T-cell leukemia virus type one (HTLV-I), a retrovirus that causes T-cell leukemia and HTLV-I-associated myelopathy in humans, has been determined by NMR methods. The protein consists of independent N and C-terminal domains connected by a flexible linker.
Potential use of a caspase against HIV.: JAMA. 1999 Sep 15;282(11):1021-2. Unique Identifier : AIDSLINE MED/99420931; Finkel TH; Division of Basic Sciences, National Jewish Medical and Research; Center, Denver, Colo, USA. finkelt@email.chop.edu
Admission trends in a rural South African hospital during the early years of the HIV epidemic.: JAMA. 1999 Sep 15;282(11):1087-91. Unique Identifier : AIDSLINE MED/99420953; Floyd K; Reid RA; Wilkinson D; Gilks CF; Division of Tropical Medicine, Liverpool School of Tropical; Medicine, England. kfloyd@liverpool.ac.uk; CONTEXT: Few studies have attempted to quantify the effect of the epidemic of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) on demand for health care in developing countries. More data are required to improve understanding of its impact and to guide development of appropriate response st
[Current strategies for treatment of CMV retinitis in patients with AIDS]: Klin Monatsbl Augenheilkd. 1999 Jul;215(1):4-9. Unique Identifier : AIDSLINE MED/99377753; Luke C; Bartz-Schmidt KU; Walter P; Heimann K; Abteilung fur Netzhaut- und Glaskorperchirurgie der; Universitat Koln.; BACKGROUND: CMV retinitis is the most common manifestation of active CMV infection in patients with AIDS. Before ganciclovir became available, the prognosis of CMV retinitis was very poor. Meanwhile a number of strategies for the management of CMV retinitis have
Absence of Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow cells from Japanese myeloma patients [letter]: Leukemia. 1999 Sep;13(9):1465-6. Unique Identifier : AIDSLINE MED/99418726; Harada N; Hata H; Matsuno F; Sonoki T; Kuribayashi N; Matsuzaki H; Mitsuya H
[Dynamics of immunoglobulin production in non infected children born from HIV-1 infected mothers: effect of zidovudine]: Med Clin (Barc). 1999 May 1;112(15):568-71. Unique Identifier : AIDSLINE MED/99293716; Resino S; Gurbindo MD; Bellon JM; Jimenez JL; Leon JA; Navarro J; Munoz-Fernandez MA; Division de Inmunologia, Hospital General Universitario; Gregorio Maranon, Madrid.; BACKGROUND: To evaluate the possible effect of zidovudine (ZDV) on inmunoglobins production in infants born to HIV-1 infected women. SUBJECTS AND METHODS: We have studied the immunoglobulins serum levels in 57 non-infected children born to HIV-infected mothers. The children were divided into two groups: group A, 28 ch
[Anorectal Hodgkin disease in an HIV-infected patient (letter)]: Med Clin (Barc). 1999 May 1;112(15):598-9. Unique Identifier : AIDSLINE MED/99293727; Marquez-Moreno AJ; Rubio-Garrido J; Rueda-Dominguez A; Blanes Berenguel A
[Serious accusations against HIV-positive persons (letter)]: Lakartidningen. 1999 Sep 8;96(36):3759-60. Unique Identifier : AIDSLINE MED/99430178; Backekihl U
Court order for HIV-1 test for baby.: Lancet. 1999 Sep 11;354(9182):884. Unique Identifier : AIDSLINE MED/99418477; Brahams D; Old Square Chambers, Gray's Inn, London, UK.
Efficacy of azithromycin in prevention of Pneumocystis carinii pneumonia: a randomised trial. California Collaborative Treatment Group.: Lancet. 1999 Sep 11;354(9182):891-5. Unique Identifier : AIDSLINE MED/99418479; Dunne MW; Bozzette S; McCutchan JA; Dube MP; Sattler FR; Forthal D; Kemper CA; Havlir D; Pfizer Central Research, Groton, CT 06340, USA. dunnem@pfizer.com; BACKGROUND: Azithromycin in combination with sulphonamides is active against Pneumocystis carinii pneumonia (PCP) in animals. We assessed the clinical efficacy of azithromycin for PCP prophylaxis in human beings. METHODS: We identified HIV-1-infected patients with PCP during a prospective randomised trial comparing az
A neonate with haemorrhagic ascites.: Lancet. 1999 Sep 11;354(9182):914. Unique Identifier : AIDSLINE MED/99418484; Pillay T; Jeena PM; Department of Paediatrics and Child Health, University of Natal,; Medical School, Durban, South Africa. pillayti@med.und.ac.za
UNAIDS to publish HIV-vaccine-trial ethics guidance [news]: Lancet. 1999 Sep 11;354(9182):923. Unique Identifier : AIDSLINE MED/99418493; Ramsay S
Immunisation with gp160 in HIV-1 infection [letter]: Lancet. 1999 Sep 11;354(9182):948; discussion 949. Unique Identifier : AIDSLINE MED/99418508; Fiala C; Stewart GT
Immunisation with gp160 in HIV-1 infection [letter]: Lancet. 1999 Sep 11;354(9182):948-9. Unique Identifier : AIDSLINE MED/99418509; Pontesilli O; Aiuti F
Relationship of hepatitis C viremia to HIV state and to infection by specific hepatitis C genotypes.: Liver. 1999 Aug;19(4):288-93. Unique Identifier : AIDSLINE MED/99387382; Perez-Gracia T; Galan F; Fernandez-Gutierrez C; Giron JA; Rodriguez-Iglesias M; Microbiology Service, Hospital Universitario Puerto Real, Spain.; AIMS/BACKGROUND: This study was undertaken to examine the relationship of hepatitis C (HCV) viremia to human immunodeficiency virus (HIV) infection and to investigate the evidence of infection by specific hepatitis C genotypes. PATIENTS AND METHODS: The analysis of HCV viremia was performed by reverse transcription-po
HBeAg immunostaining of liver tissue in various stages of chronic hepatitis B.: Liver. 1999 Aug;19(4):294-8. Unique Identifier : AIDSLINE MED/99387383; Lindh M; Savage K; Rees J; Garwood L; Horal P; Norkrans G; Dhillon AP; Department of Clinical Virology, Goteborg University, Sweden.; AIMS: We studied the tissue expression of hepatitis B e antigen (HBeAg) in 29 liver biopsies from 27 HBV carriers. METHODS: HBeAg expression was assessed in relation to HBeAg in serum, precore mutations, HBV DNA levels and liver damage as measured by histology activity index. RESULTS: HBeAg in liver tissue was detecte
Screening blood donations for hepatitis C in Central Africa: analysis of a risk- and cost-based decision tree.: Med Decis Making. 1999 Jul-Sep;19(3):296-306. Unique Identifier : AIDSLINE MED/99352122; Cancre N; Bois F; Gresenguet G; Fretz C; Fournel JJ; Belec L; B3E-INSERM U444, Faculte de Medecine St. Antoine, Paris,; France.; Four screening strategies (no testing, HC Abbott, HC Pasteur, and a combined test) for the detection of hepatitis C virus (HCV) antibody in donated blood were considered in a formal decision tree. Decision criteria included residual risk of infection and overall monetary cost. Tree parameters were determined using dat
Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection.: Med Sci Sports Exerc. 1999 Jul;31(7):973-9. Unique Identifier : AIDSLINE MED/99342947; Perna FM; LaPerriere A; Klimas N; Ironson G; Perry A; Pavone J; Goldstein A; Majors P; Makemson D; Talutto C; Schneiderman N; Fletcher MA; Meijer OG; Koppes L; School of Physical Education, Sport Psychology Program, West; Virginia University, Morgantown 26506-6116, USA.; PURPOSE: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was asso
1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. U.S. Public Health Service (USPHS) and Infectious Diseases Society of America (IDSA).: MMWR Morb Mortal Wkly Rep. 1999 Aug 20;48(RR-10):1-59, 61-6. Unique Identifier : AIDSLINE MED/99428016
The AIDS epidemic--considerations for the 21st century.: N Engl J Med. 1999 Sep 30;341(14):1046-50. Unique Identifier : AIDSLINE MED/99417083; Fauci AS; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.; afauci@niaid.nih.gov
Call for governments to back development of AIDS vaccine [news]: Nature. 1999 Sep 2;401(6748):4. Unique Identifier : AIDSLINE MED/99413700; Dickson D
Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells.: Nature. 1999 Sep 2;401(6748):76-9. Unique Identifier : AIDSLINE MED/99413718; Slifka MK; Rodriguez F; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California 92037, USA. mslifka@scripps.edu; CD8-positive T cells protect the body against viral pathogens by two important mechanisms: production of antiviral cytokines and lysis of infected cells. Cytokine production can have both local and systemic consequences, whereas cytolytic activity is limited to infected cells that are in direct contact with T cells. H
Microbiological and radioactive contamination from radioaerosol ventilation scanning: is there a problem?: Nucl Med Commun. 1999 Aug;20(8):755-60. Unique Identifier : AIDSLINE MED/99381191; Brown A; Carter NJ; O'Doherty MJ; Department of Nuclear Medicine, Kent and Canterbury Hospital, UK.; Radioaerosol lung imaging may result in (a) microbiological contamination of nebulizer circuits (a potential hazard to patients if the circuit is re-used), and (b) radioaerosol contamination of the atmosphere (a hazard to staff, particularly if inhaled, ingested or both). Altogether, 138 circuits were assessed for bac
The absence of correlation between immunoregulatory T cells and induced lymphoproliferative response in treated B-chronic lymphocytic leukemia patients.: Panminerva Med. 1999 Jun;41(2):93-7. Unique Identifier : AIDSLINE MED/99409175; Milosevic D; Marinkovic M; Colovic M; Jelic S; Institute for Oncology and Radiology of Serbia, Belgrade,; Yugoslavia.; BACKGROUND: Many data suggest T cell functional impairment in B-cell chronic lymphocytic leukemia (B-CLL). The mechanism responsible for this phenomenon is still unresolved. METHODS: In 88 B-CLL patients (RAI II-IV) the relationship between immunoregulatory T cells and PHA induced lymphoproliferative response (LPR) wa
Serotype distribution and secretory acid proteinase activity of Candida albicans isolated from the oral mucosa of patients with denture stomatitis.: Oral Microbiol Immunol. 1999 Jun;14(3):183-9. Unique Identifier : AIDSLINE MED/99425720; McMullan-Vogel CG; Jude HD; Ollert MW; Vogel CW; Department of Prosthodontics, University Hospital Eppendorf,; Germany.; Denture stomatitis is the most common form of oral Candida infection in humans. In the current study, the distribution of Candida albicans serotype A and B as well as the activity of the secreted acid proteinase were determined in clinical isolates from patients with denture stomatitis. It was found that 70% of indivi
Immunizations for the immunocompromised child.: Pediatr Ann. 1999 Aug;28(8):487-96. Unique Identifier : AIDSLINE MED/99413092; McFarland E; Children's Hospital Immunodeficiency Program, University of; Colorado Health Sciences Center, Denver 80262, USA.; Although immunocompromised children are unlikely to have optimal immune responses to vaccines, some will benefit from immunization. They should receive inactivated vaccines that are routinely recommended for immunocompetent children plus pneumococcal and influenza immunizations. Live viral and bacterial vaccines are c
HIV infection and seizures.: Postgrad Med J. 1999 Jul;75(885):387-90. Unique Identifier : AIDSLINE MED/99403968; Garg RK; Department of Neurology, Banaras Hindu University, Varanasi,; India.; New-onset seizures are frequent manifestations of central nervous system disorders in patients infected with human immunodeficiency virus (HIV). Seizures are more common in advanced stages of the disease, although they may occur early in the course of illness. In the majority of patients, seizures are of the generalis
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.: Pharm Res. 1999 Jul;16(7):1035-40. Unique Identifier : AIDSLINE MED/99378136; Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P; Laboratorium voor Farmacotechnologie en Biofarmacie, O&N,; KULeuven, Belgium.; PURPOSE: To explore the usefulness of fruit extracts as enhancers of the oral absorption of esterase-sensitive prodrugs. METHODS: Inhibition of esterase-mediated degradation by nature-identical fruit extracts was evaluated using 1) p-nitrophenylacetate (model substrate for esterase-activity) in rat intestinal homogena
An epidemiological review of tuberculosis in the Puerto Rican population.: P R Health Sci J. 1999 Jun;18(2):117-22. Unique Identifier : AIDSLINE MED/99390418; Perez-Perdomo R; Perez-Cardona CM; University of Puerto Rico, Graduate School of Public Health,; Department of Biostatistics and Epidemiology, San Juan; 00936-5067. ros_perez@rcmaca.upr.clu.edu; Past and recent developments related with tuberculosis (TB) epidemiology in the island were reviewed. Characteristics of the disease such as surveillance, incidence, mortality and the relation of TB with HIV infection were included. TB remains an important public health problem in
[The efficacy of sequential treatment with amphotericin B-fluorocytosine and fluconazole in cryptococcal meningitis not associated with AIDS (letter)]: Rev Clin Esp. 1999 Jul;199(7):480. Unique Identifier : AIDSLINE MED/99411185; Pintado Garcia V; Martin Davila P; Munoz Labian V; Quereda Rodriguez-Navarro C
[A very, very short of breath HIV-infected patient]: Rev Med Interne. 1999;20 Suppl 2:256s-259s. Unique Identifier : AIDSLINE MED/99351061; Megarbane B; Fromont C; Nion I; Chary I; Axler O; Slama A; Brivet M; Rustin P; Munnich A; Brivet F; Service des urgences medicales et de reanimation medicale,; hopital Antoine-Beclere, Clamart.
[Why to look for vermin?]: Rev Med Interne. 1999;20 Suppl 2:277s-278s. Unique Identifier : AIDSLINE MED/99351068; Ribier G; Schroder S; Ramialison C; Service de medecine interne, CHU de la meynard, Fort de France.
Visit-driven endpoints in randomized HIV/AIDS clinical trials: impact of missing data on treatment difference measured on summary statistics.: Stat Med. 1999 Jul 30;18(14):1803-17; discussion 1819. Unique Identifier : AIDSLINE MED/99337845; Le Corfec E; Chevret S; Costagliola D; INSERM U444, Faculte de Medecine St-Antoine, 27 rue Chaligny,; 75571 Paris Cedex 12, France.; In randomized HIV/AIDS clinical trials, CD4 lymphocyte counts and plasma HIV-1 RNA measurements are often used as endpoints. The comparison between treatment groups is mainly based on a summary measure of outcome, so-called summary statistic. Such analyses are often complicated by missing data occurring as drop-outs.
Estimation of the treatment effect in a clinical trial when recurrent events define the endpoint.: Stat Med. 1999 Jul 30;18(14):1821-9; discussion 1831. Unique Identifier : AIDSLINE MED/99337847; Mahe C; Chevret S; Departement de Biostatistique et Informatique Medicale,; Hopital St-Louis, INSERM U444, 1 avenue Claude Vellefaux, 75475; Paris cedex 10, France.; Recurrent events are frequently encountered in clinical trials when individuals may experience an event more than once. Examples are common in medical research, including infectious episodes, myocardial infarctions and hospital admissions. However, when only the first event is considered, there is a loss of informatio
[Management of professional exposures to blood and other biological liquids contaminated with hepatitis B and C and HIV]: Rev Med Suisse Romande. 1999 Jul;119(7):587-92. Unique Identifier : AIDSLINE MED/99397184; Dubey BR; Telenti A; Francioli P
[Palliative care in non-cancerous diseases]: Rev Prat. 1999 May 15;49(10):1069-72. Unique Identifier : AIDSLINE MED/99414846; Blanchet V; Equipe mobile de soins palliatifs, Hopital Saint-Louis, Paris.; Palliative treatment is instituted at a particular point in the course of a potentially fatal disease. This palliative phase is often less well-defined than in cancer. Treatment mainly aims at slowing the course of the disease and maintaining the best quality of life possible for the patient. Palliative management of
Collaboration between developing and developed countries and between developing countries in occupational health research and surveillance.: Scand J Work Environ Health. 1999 Jun;25(3):296-300. Unique Identifier : AIDSLINE MED/99377992; Partanen TJ; Hogstedt C; Ahasan R; Aragon A; Arroyave ME; Jeyaratnam J; Kurppa K; Loewenson R; Lundberg I; Ngowi AV; Mbakaya CF; Stayner L; Steenland K; Weiderpass E; Wesseling C; Department of Epidemiology and Biostatistics, Finnish Institute; of Occupational Health, Helsinki. timo.partanen@occuphealth.fi; Collaborative occupational health and safety studies between counterparts in developing and developed countries and between developing countries have demonstrated their potential for improving occupational health and safety. Such collaboration in occupational health and safety is encouraged in the development of infra
Race on for local AIDS vaccine [news]: S Afr Med J. 1999 Jun;89(6):582. Unique Identifier : AIDSLINE MED/99372145; Jones JS
All about AIDS [news]: S Afr Med J. 1999 Jun;89(6):583. Unique Identifier : AIDSLINE MED/99372146; Jones JS
AIDS to become notifiable disease? [news]: S Afr Med J. 1999 Jun;89(6):583. Unique Identifier : AIDSLINE MED/99372147; van der Linde I
SAMA Committee wants free AZT for rape survivors [news]: S Afr Med J. 1999 Jun;89(6):584. Unique Identifier : AIDSLINE MED/99372148; van der Linde I
UNAIDS and BMS to combat AIDS [news]: S Afr Med J. 1999 Jun;89(6):585. Unique Identifier : AIDSLINE MED/99372149; van der Linde I
Making AIDS a notifiable disease--is it an appropriate policy for South Africa?: S Afr Med J. 1999 Jun;89(6):609-11. Unique Identifier : AIDSLINE MED/99372152; Abdool Karim SS; Center for Epidemiological Research in South Africa, Medical; Research Council, Durban.
Denying effective antiretroviral drugs to HIV-positive pregnant women--the national government's flawed decision [editorial]: S Afr Med J. 1999 Jun;89(6):621-3. Unique Identifier : AIDSLINE MED/99372155; Lurie M; Lurie P; IJsselmuiden C; Gray G
Mortality in a cohort of children born to HIV-1 infected women from Durban, South Africa.: S Afr Med J. 1999 Jun;89(6):646-8. Unique Identifier : AIDSLINE MED/99372163; Bobat R; Coovadia H; Moodley D; Coutsoudis A; Department of Paediatrics and Child Health, University of Natal.; OBJECTIVES: To describe mortality in a cohort of infants with vertically transmitted HIV-1 infection. PATIENTS AND METHODS: Children of HIV-1 infected women were followed up from birth and a record was made at each visit of growth, development and all illnesses. Details surrounding death were obtained from hospital re
Use of antiviral agents in pregnant women with HIV infection [letter]: S Afr Med J. 1999 Jul;89(7):704. Unique Identifier : AIDSLINE MED/99399310; Nash E; Benatar S; Abratt R; van Zyl Smit R; van Niekerk JP; Meyerson D; Ress S; Kyriacos U; Sanders HR; Stewart C; Peter E
["Safe sex" among HIV-positive heterosexual couples]: Ugeskr Laeger. 1999 Jun 14;161(24):3666-9. Unique Identifier : AIDSLINE MED/99414882; Weis NM; Skinnes L; Vesterdal B; Aabech P; Mathiesen LR; H:S Hvidovre Hospital, infektionsmedicinsk afdeling.; To investigate the use of condoms ( safe sex ) as prevention of transmission with human immuno deficiency virus (hiv) among heterosexual couples, 57 hiv-positive heterosexual patients and their partners if there was one interviewed. Forty-three of the 57 patients were heterosexually infected. Five out of 30 patients i
[Treatment for infertility in HIV positive couples--psychosomatic and ethical considerations]: Zentralbl Gynakol. 1999;121 Suppl 1:50-2. Unique Identifier : AIDSLINE MED/99397010; Siedentopf F; Kentenich H; DRK Frauen- und Kinderklinik, Berlin.
Absence of thallium-201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients.: Acta Neurol Scand. 1999 Aug;100(2):102-5. Unique Identifier : AIDSLINE MED/99369055; Iranzo A; Marti-Fabregas J; Domingo P; Catafau A; Molet J; Moreno A; Pujol J; Matias-Guiu X; Cadafalch J; Department of Neurology, Santa Creu i Sant Pau Hospital,; Autonomous University of Barcelona, Spain.; OBJECTIVE: To evaluate the presence of thallium-201 brain uptake determined by thallium-201 brain SPECT (Tl-201 SPECT) in patients with progressive multifocal leukoencephalopathy (PML) and AIDS. MATERIAL AND METHODS: Six AIDS patients with stereotactic biopsy diagnosis of PML were prospectively evaluated with Tl-201 S
[The treatment of cytomegalovirus retinitis in human immunodeficiency virus infection]: Acta Med Port. 1999 Apr-Jun;12(4-6):203-7. Unique Identifier : AIDSLINE MED/99410937; Rabadao E; Duque V; Melico-Silvestre A; Departamento de Doencas Infecciosas, Hospitais da Universidade; de Coimbra.; Most of the patients with immunodeficiency virus infection (75%-85%) are coinfected with cytomegalovirus . It is estimated that cytomegalovirus disease develops in 45% of them, mainly those presenting low CD4 cell counts (
[Kaposi's sarcoma: a sexually transmitted cancer?]: Actas Urol Esp. 1999 Feb;23(2):89-94. Unique Identifier : AIDSLINE MED/99259655; Sousa Escandon MA; Picallo Sanchez JA; Arguelles Pintos M; Alonso Alonso P; Alvarez Asensio E; Mateos Colino A; Servicio de Urologia, Hospital Comarcal de Monforte, Lugo.; Kaposi s sarcoma is a lymphoproliferative opportunistic tumor associated with acquired immunodeficiency syndrome whose frequency is going down due to the use of combined therapies including proteases and others antivirals. During the last years, it has been postulated that it s origin is in the oncogenic potential of
[Painful erections related to sleeping]: Actas Urol Esp. 1999 Jun;23(6):539-41. Unique Identifier : AIDSLINE MED/99394231; Menendez Lopez V; Mora Rufete A; Prieto Chaparro L; Galan Llopis JA; Fernandez Puentes C; Garcia Lopez F; Servicio de Urologia, Hospital General Universitario de Elche,; Universidad Miguel Hernandez, Alicante.; Case report of sleep-related painful erections in a 34 year-old male with grade C3 HIV infection. Due to severe impairment of the patient s general condition, no proper diagnostic studies were performed to gain deeper knowledge of the symptom s pathological etiology. Empirical therapy was started based on evidence fro
Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs.: Addict Behav. 1999 Jul-Aug;24(4):559-63. Unique Identifier : AIDSLINE MED/99394727; van Ameijden EJ; Langendam MW; Coutinho RA; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; evameijden@GGGD.amsterdam.nl; The present study evaluates the effectiveness of low-threshold methadone maintenance in reducing overdose mortality. In a prospective cohort study conducted in Amsterdam, 498 Dutch injecting drug users (IDU) provided 1,969 person years of follow-up (1989-1995). Forty-four IDU died in this period, 15 due to illicit dru
Reducing HIV risk-associated sexual behavior among African American adolescents: testing the generality of intervention effects.: Am J Community Psychol. 1999 Apr;27(2):161-87. Unique Identifier : AIDSLINE MED/99354430; Jemmott JB 3rd; Jemmott LS; Fong GT; McCaffree K; Princeton University, Department of Psychology, New Jersey; 08544-1010, USA. jemmott@princeton.edu; This randomized controlled trial tested the effects of a theory-based culture-sensitive HIV risk-reduction intervention among 496 inner-city African American adolescents (mean age = 13 years) and examined the generality of its effects as a function of the facilitator s race and gender and the gender composition of the
Risk factors for HIV-1 shedding in semen.: Am J Epidemiol. 1999 Sep 15;150(6):622-31. Unique Identifier : AIDSLINE MED/99418534; Speck CE; Coombs RW; Koutsky LA; Zeh J; Ross SO; Hooton TM; Collier AC; Corey L; Cent A; Dragavon J; Lee W; Johnson EJ; Sampoleo RR; Krieger JN; Department of Epidemiology, University of Washington, Seattle; 98195, USA.; Semen is the body fluid most commonly associated with sexual transmission of human immunodeficiency virus type-1 (HIV-1). Because the male genitourinary tract is distinct immunologically from blood, compartment-dependent factors may determine HIV-1 shedding in semen. To identify these factors, the authors obtained 411
First AIDS vaccine trial in Africa [news]: Am J Nurs. 1999 Jun;99(6):17. Unique Identifier : AIDSLINE MED/99419395
Protease inhibitors--worldwide use? [news]: Am J Nurs. 1999 Jun;99(6):17. Unique Identifier : AIDSLINE MED/99419396
HIV-related pain.: Am J Nurs. 1999 Jun;99(6):20. Unique Identifier : AIDSLINE MED/99419399; Hughes AM; Pasero C; Department of Nursing, San Francisco General Hospital Medical; Center, CA, USA.
Dan and me, taking care of ourselves.: Unique Identifier : AIDSLINE MED/99419408; Rivera B; Emergency Department, Mt. Sinai Medical Center, New York, NY,; USA.
Thinking critically about delegation.: Am J Nurs. 1999 Jun;99(6):61-2. Unique Identifier : AIDSLINE MED/99419409; Davidson SB; Scott R; Minarik P; School of Nursing, Oregon Health Sciences University, Portland,; USA.
HIV & AIDS. Are you biased?: Am J Nurs. 1999 Sep;99(9):38-9. Unique Identifier : AIDSLINE MED/99419425; Bormann J; Kelly A; University of California at San Diego, USA.
Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.: Ann Intern Med. 1999 Oct 5;131(7):502-6. Unique Identifier : AIDSLINE MED/99423356; Brodine SK; Shaffer RA; Starkey MJ; Tasker SA; Gilcrest JL; Louder MK; Barile A; VanCott TC; Vahey MT; McCutchan FE; Birx DL; Richman DD; Mascola JR; Graduate School of Public Health, San Diego State University,; California 92182-4162, USA.; BACKGROUND: Regular testing of military personnel identifies early HIV infection; this identification provides a sentinel cohort in which to describe the evolving molecular epidemiology of HIV-1 transmission. OBJECTIVE: To describe the prevalence and epidemiologic correlates associated with the acquisition of non-subt
Misdiagnosis of HIV infection [letter]: Ann Intern Med. 1999 Oct 5;131(7):546-7; discussion 547-8. Unique Identifier : AIDSLINE MED/99423376; Palmas W
Misdiagnosis of HIV infection [letter]: Ann Intern Med. 1999 Oct 5;131(7):547; discussion 547-8. Unique Identifier : AIDSLINE MED/99423377; Goodman C; Emmons W; Newton J
Myocardial infarction in HIV-infected men receiving protease inhibitors [letter]: Ann Intern Med. 1999 Oct 5;131(7):548. Unique Identifier : AIDSLINE MED/99423378; Flynn TE; Bricker LA
The use of monoclonal antibody R92F6 and polymerase chain reaction to confirm the presence of parvovirus B19 in bone marrow specimens of patients with acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1999 Sep;123(9):768-73. Unique Identifier : AIDSLINE MED/99387907; Vadlamudi G; Rezuke WN; Ross JW; Cartun RW; Ackroyd R; Knibbs DR; Tsongalis GJ; Department of Pathology, Hartford Hospital, Hartford, CT 061022,; USA.; BACKGROUND: Parvovirus B19 infection is a cause of chronic anemia and red cell aplasia in patients with acquired immunodeficiency syndrome (AIDS) and in other immunocompromised hosts. Anemia in AIDS patients has a multifactorial etiology, with parvovirus B19 infection being an infrequent but nevertheless treatable cau
BK virus renal infection in a patient with the acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1999 Sep;123(9):807-11. Unique Identifier : AIDSLINE MED/99387914; Nebuloni M; Tosoni A; Boldorini R; Monga G; Carsana L; Bonetto S; Abeli C; Caldarelli R; Vago L; Costanzi G; L. Sacco Institute of Biomedical Sciences, Pathology Unit, Milan,; Italy.; BACKGROUND: We describe herein a patient with the acquired immunodeficiency syndrome and renal failure due to biopsy-proven BK virus (BKV) infection. Three months after the diagnosis of the renal viral infection, his condition remained unchanged. Although BKV has previously been shown to be associated with ureteral st
Coinfection of visceral leishmaniasis and Mycobacterium in a patient with acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1999 Sep;123(9):835-7. Unique Identifier : AIDSLINE MED/99387921; Wang J; Vanley C; Miyamoto E; Turner JA; Peng SK; Department of Pathology, Harbor-UCLA Medical Center, University; of California Los Angeles, Torrance, CA 90509, USA.; We report a case of coinfection of visceral leishmaniasis and Mycobacterium avium-intracellulare in the same lesions in the small bowel and bone marrow of a 33-year-old man with acquired immunodeficiency syndrome who complained of abdominal pain and chronic diarrhea. The duodenal mucosa and bone marrow biopsy specimen
Endogenous salivary inhibitors of human immunodeficiency virus.: Unique Identifier : AIDSLINE MED/99329765; Shugars DC; Alexander AL; Fu K; Freel SA; Department of Dental Ecology, School of Dentistry, University of; North Carolina at Chapel Hill, USA.; The human immunodeficiency virus type 1 (HIV-1) is rarely transmitted through salivary secretions, due in part to the presence of endogenous inhibitors. Here, the protective characteristics of the intraoral environment are summarized and inhibitory factors that reduce HIV-1 infectivity in vitro described, focusing on
Clinico-immunopathological alterations of lymph nodes from human immunodeficiency virus-infected patients in northern Thailand.: Asian Pac J Allergy Immunol. 1999 Jun;17(2):85-92. Unique Identifier : AIDSLINE MED/99394419; Bhoopat L; Patanasakpinyo C; Yanaranop M; Bhoopat T; Department of Pathology, Faculty of Medicine, Chiang Mai; University, Thailand.; To determine if the immunopathologic alterations of HIV-infected lymph nodes have any correlation with clinical stages in the northern Thai patients, we conducted a comparative analysis of immunopathologic features of lymph nodes between 25 HIV-infected patients from various clinical categories and 25 non-HIV individu
Risk-benefit assessment of therapies for Mycobacterium avium complex infections.: Drug Saf. 1999 Aug;21(2):137-52. Unique Identifier : AIDSLINE MED/99383284; Griffith DE; Center for Pulmonary Infectious Disease Control, The University; of Texas Health Center at Tyler, 75708, USA. griffith@uthct.edu; Mycobacterium avium complex (MAC) is an important pathogen that can cause chronic lung disease in immunocompetent patients and disseminated disease in patients with the acquired immunodeficiency syndrome (AIDS). Treatment of MAC with antituberculosis drugs was unsatisfactory, but the introduction of the newer macrolid
Drug-induced lymphopenia: focus on CD4+ and CD8+ cells.: Drug Saf. 1999 Aug;21(2):91-100. Unique Identifier : AIDSLINE MED/99383281; Gergely P; Central Laboratory of Immunology, Semmelweis University,; Budapest, Hungary.; Drug-induced lymphopenia is a common adverse event. Some drugs, in particular those used in the treatment of malignancies and autoimmune diseases, inevitably affect the percentages and proportions of lymphocytes in the peripheral blood. Some other drugs exert only minor effects and their clinical relevance cannot be e
Salvage treatment against human immunodeficiency virus.: Ann Med. 1999 Aug;31(4):253-60. Unique Identifier : AIDSLINE MED/99408633; Battegay M; Harr T; Sponagel L; Basel Center for HIV-Research, Outpatient Department of Internal; Medicine, University Hospital Basel, Switzerland.; battegaym@ubaclu.unibas.ch; Despite dramatic declines in human immunodeficiency virus (HIV)-associated morbidity and mortality as a result of highly active antiretroviral combination therapies, including protease inhibitors , treatment failure occurs at such high rates as 20-50%. As drug regime
Dietary fatty acids and allergy.: Ann Med. 1999 Aug;31(4):282-7. Unique Identifier : AIDSLINE MED/99408636; Kankaanpaa P; Sutas Y; Salminen S; Lichtenstein A; Isolauri E; Department of Biochemistry and Food Chemistry, University of; Turku, Finland. pasi.kankaanpaa@utu.fi; The increase in the prevalence of atopic diseases has recently been linked to altered consumption of polyunsaturated fatty acids (PUFAs). As typical Western diets contain almost 10 times more linoleic acid (18:2 omega-6) than alpha-linolenic acid (18:3 omega-3), it is the metabolism of the former that predominates. Su
Healthy gut microflora and allergy: factors influencing development of the microbiota.: Ann Med. 1999 Aug;31(4):288-92. Unique Identifier : AIDSLINE MED/99408637; Kirjavainen PV; Gibson GR; Department of Biochemistry and Food Chemistry, University of; Turku, Finland. pirkka.kirjavainen@utu.fi; In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de
Treatment outcome in presumed and confirmed AIDS-related primary cerebral lymphoma.: Eur J Cancer. 1999 Apr;35(4):601-4. Unique Identifier : AIDSLINE MED/99422302; Bower M; Fife K; Sullivan A; Kirk S; Phillips RH; Nelson M; Gazzard BG; Department of Oncology, Chelsea & Westminster Hospital, London,; U.K. m.bower@cxwms.ac.uk; A retrospective analysis identified 38 HIV seropositive patients with a diagnosis of presumed (n = 26) or confirmed (n = 12) primary cerebral lymphoma (PCNSL). All patients had failed to respond to empirical antitoxoplasma therapy and the clinical diagnosis of PCNSL was confirmed by brain biopsy (n = 4), cerebrospinal
Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer.: Eur J Cancer. 1999 May;35(5):721-6. Unique Identifier : AIDSLINE MED/99434655; Diederichsen AC; Zeuthen J; Christensen PB; Kristensen T; Department of Clinical Immunology, Odense University Hospital,; Denmark. a.diederichsen@winsloew.ou.dk; Using flow cytometry, we studied the phenotype of tumour infiltrating lymphocytes (TILs) in 41 enzymatically dissociated colorectal cancers and compared this to the expression of HLA class I and II and CD80 on tumour cells. We studied the possible enzymatic damage to various surface markers after enzymatic dissociatio
Blood safety in the Americas.: Epidemiol Bull. 1999 Jun;20(2):8-9. Unique Identifier : AIDSLINE MED/99407941
Changes in incarcerated adolescents' human immunodeficiency virus knowledge and selected behaviors from 1988 to 1996.: J Adolesc Health. 1999 Sep;25(3):182-6. Unique Identifier : AIDSLINE MED/99402479; Lanier MM; Pack RP; DiClemente RJ; College of Health and Public Affairs, University of Central; Florida, Orlando 32816, USA.; Data were collected from juveniles in Alabama and Florida correctional facilities. The samples were closely demographically matched. Analysis indicated significant increases in knowledge about human immunodeficiency virus between 1988 and 1996 and increased sexual risk behaviors. Knowledge levels were lower for ethnic
HIV prevention in street youth.: J Adolesc Health. 1999 Sep;25(3):187-98. Unique Identifier : AIDSLINE MED/99402480; Walters AS; Department of Psychology, Hobart and William Smith Colleges,; Geneva, New York 14456, USA.; Homeless adolescents have remained an underserved population throughout the human immunodeficiency/acquired immune deficiency syndrome epidemic. This article reviews the recent literature investigating human immunodeficiency virus (HIV) risk behavior among street youth. Prevalence rates of both adolescent homelessness
Hematopoietic donor chimerism and graft-versus-myeloma effect in relapse of multiple myeloma after allogeneic bone marrow transplantation.: Ann Hematol. 1999 Aug;78(8):376-9. Unique Identifier : AIDSLINE MED/99389592; Keil F; Kalhs P; Chen X; Haas OA; Fritsch G; Chott A; Lechner K; Moser K; Ackermann J; Rabitsch W; Worel N; Mannhalter C; Greinix HT; Department of Medicine 1, Bone Marrow Transplantation Unit,; University of Vienna, Austria. felix.keil@akh-wien.ac.at; A large group of patients relapsing after allogeneic bone marrow transplantation (BMT) have obtained remission after infusion of leukocytes from their original donor, suggesting a graft-versus-myeloma effect. However, side effects such as graft-versus-host disease and myelosuppression are severe, and sometimes fatal,
High-dose natural interferon-alpha therapy for chronic hepatitis C with a high viral load: predictors of efficacy. The Aomori, Akita and Iwate Areas Viral Hepatitis Research Group.: J Gastroenterol Hepatol. 1999 Jul;14(7):675-81. Unique Identifier : AIDSLINE MED/99366824; Komatsu M; Suto T; Ishikawa K; Sato S; First Department of Internal Medicine, Akita University School of; Medicine, Akita City, Japan.; BACKGROUND: The effectiveness of interferon against hepatitis C has been found to be greatly affected by viral factors. However, few controlled interferon trials have involved seemingly intractable cases of chronic hepatitis C. METHODS: In 44 patients with high hepatitis C virus RNA levels (> or = 10(5) copies/mL), we
Focal brain lesions in acquired immunodeficiency syndrome: DNA diagnosis and further monitoring [editorial; comment]: Intern Med. 1999 Jul;38(7):521. Unique Identifier : AIDSLINE MED/99361707; Kira J
Detection of Toxoplasma gondii, Epstein-Barr virus, and JC virus DNAs in the cerebrospinal fluid in acquired immunodeficiency syndrome patients with focal central nervous system complications [see comments]: Intern Med. 1999 Jul;38(7):556-62. Unique Identifier : AIDSLINE MED/99361714; Tachikawa N; Goto M; Hoshino Y; Gatanaga H; Yasuoka A; Wakabayashi T; Katano H; Kimura S; Oka S; Iwamoto A; AIDS Clinical Center, International Medical Center of Japan,; Tokyo.; OBJECT: Toxoplasmic encephalitis (TE), primary central nervous system lymphoma (PCNSL) and progressive multifocal leukoencephalopathy (PML) are major central nervous system (CNS) diseases in patients with acquired immunodeficiency syndrome (AIDS). We assessed the diagnostic value of polymerase chain reaction (PCR) in
Fat-free mass in chronic illness: comparison of bioelectrical impedance and dual-energy x-ray absorptiometry in 480 chronically ill and healthy subjects.: Nutrition. 1999 Sep;15(9):668-76. Unique Identifier : AIDSLINE MED/99396942; Pichard C; Kyle UG; Slosman DO; Division of Clinical Nutrition, Geneva University Hospital,; Switzerland. pichard@cmu.unige.ch; Assessment of fat-free mass (FFM) and fat mass in ambulatory and hospitalized patients permits optimal adaptation of nutrition support. Recent methods for the determination of FFM are dual-energy x-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA). The purpose of this study was to determine if the BI
Selenium and HIV infection [editorial]: Nutrition. 1999 Sep;15(9):719-20. Unique Identifier : AIDSLINE MED/99396951; Constans J; Conri C; Sergeant C
[Hematologic abnormalities and immunodepression in HIV/AIDS- related pulmonary tuberculosis]: Bull Soc Pathol Exot. 1999 Jul;92(3):161-3. Unique Identifier : AIDSLINE MED/99401660; Hane AA; Thiam D; Cissokho S; Kabou F; Ndiaye M; Diop S; Ba O; Fall K; Diop BM; Ndir M; Diedhiou A; Toure-Fall AO; Diakhate L; Clinique de pneumologie, CHU Fann, Dakar, Senegal.; Our objectives were to describe hemato-immunological abnormalities encountered in tuberculosis patients HIV seropositive (TBVIH+, n = 67) or not (TBVIH-, n = 39) and in HIV asymptomatic patients (aSVIH+, n = 40). We found: a great reduction of mean value of RBC and Hb in TBVIH+ and TBVIH-; a reduction of mean value of
Pneumocystis carinii infection in human immunodeficiency virus-positive patients.: Br J Biomed Sci. 1999;56(1):39-48. Unique Identifier : AIDSLINE MED/99422582; Looney WJ; Windsor JJ; Institute of Medical Microbiology, University of Berne,; Switzerland.; Pneumocystis carinii is a ubiquitous, atypical unicellular fungus. P. carinii pneumonia (PCP) is responsible for considerable morbidity and mortality in acquired immune deficiency syndrome (AIDS) patients, and is the leading complication in advanced human immunodeficiency virus (HIV) infection. Many different host (ma
Human herpes virus 8 (HHV8) serology in allogeneic bone marrow transplant recipients.: Bone Marrow Transplant. 1999 Aug;24(4):351-4. Unique Identifier : AIDSLINE MED/99398156; Rosenzwajg M; Fery N; Bons V; Damaj G; Gluckman E; Gluckman J; Service d'Immunologie Biologique, Hopital de la; Pitie-Salpetriere, Paris, France.; Human herpes virus 8 (HHV8) may be sexually transmitted, but transmission via blood cells has not yet been excluded. We used a modified immunofluorescence assay to detect Ab to HHV8 latency-associated nuclear Ag in sera of 200 allogeneic BMT recipients and their related donors. In control subjects, Ab were found in 85
VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death.: Brain Res. 1999 Aug 14;838(1-2):27-36. Unique Identifier : AIDSLINE MED/99376697; Brenneman DE; Hauser J; Spong CY; Phillips TM; Pert CB; Ruff M; Section on Developmental and Molecular Pharmacology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD 20892, USA.; dbrenn@codon.nih.gov; Vasoactive intestinal peptide (VIP) and DAPTA (D-ala(1)-peptide T-amide, a gp120-derived octapeptide homologous to VIP) prevent neuronal cell death produced by five variants of HIV-1 (human immunodeficiency virus) envelope protein (gp120). VIP or DAPTA treatment of astrocyte cultures resulted in the release of macroph
Evaluation of IgE-sensitization to fungi in HIV-positive patients with eczematous skin reactions.: Ann Allergy Asthma Immunol. 1999 Aug;83(2):153-9. Unique Identifier : AIDSLINE MED/99408467; Nissen D; Nolte H; Permin H; Heinig J; Skov PS; Norn S; Department of Infectious Diseases, National University Hospital,; Copenhagen, Denmark.; BACKGROUND: Human immunodeficiency virus infection is associated with declining immune function and polyclonal B-cell activation leading to elevated IgE-levels. In selected patient categories, increased total IgE may be associated with allergic diseases. Furthermore, a significant number of patients with low CD4+ cell
Low IgG3 and high IgG4 subclass levels in children with advanced human immunodeficiency virus-type 1 infection and elevated IgE levels.: Ann Allergy Asthma Immunol. 1999 Aug;83(2):160-4. Unique Identifier : AIDSLINE MED/99408468; de Martino M; Rossi ME; Azzari C; Chiarelli F; Galli L; Vierucci A; Department of Medicine, Section of Pediatrics, University of; Chieti, Italy.; BACKGROUND: IgG3 and IgG4 levels are not always changed in children perinatally infected with human immunodeficiency virus-type 1 (HIV-1). Elevated IgE levels hallmark the TH1 to TH2 switch occurring in advanced infection and such an unbalanced cytokine network may affect the IgG subclass production. OBJECTIVE: To exa
An effective strategy of human tumor vaccine modification by coupling bispecific costimulatory molecules.: Cancer Gene Ther. 1999 May-Jun;6(3):254-62. Unique Identifier : AIDSLINE MED/99285706; Haas C; Herold-Mende C; Gerhards R; Schirrmacher V; German Cancer Research Center, Tumor Immunology Program,; Heidelberg.; A new, generally applicable procedure is described for the introduction of defined costimulatory molecules into human cancer cells to increase their T-cell stimulatory capacity. The procedure involves infection with Newcastle disease virus to mediate the cell surface binding of costimulatory molecules (e.g., specially
A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T cell repertoire.: Mol Med. 1998 Dec;4(12):783-94. Unique Identifier : AIDSLINE MED/99153953; Batliwalla FM; Bateman BA; Serrano D; Murray D; Macphail S; Maino VC; Ansel JC; Gregersen PK; Armstrong CA; North Shore University Hospital-NYU School of Medicine, 350; Community Drive, Manhasset, New York, USA.; BACKGROUND: The development of effective adjuvant therapies for the treatment of high-risk melanoma patients is critical for the prevention of metastatic disease and improvement of patient survival. Active specific immunotherapy has been tested as an adjuvant treatment in numerous clinical trials with overall limited,
A novel 5 displacement spin-labeling technique for electron paramagnetic resonance spectroscopy of RNA.: RNA. 1999 Sep;5(9):1158-66. Unique Identifier : AIDSLINE MED/99424536; Macosko JC; Pio MS; Tinoco I Jr; Shin YK; Department of Chemistry, University of California, Berkeley,; Lawrence Berkeley National Laboratory 94720-1460, USA.; An RNA spin-labeling technique was developed using the well-characterized interaction between the HIV Rev peptide and the Rev response element (RRE) RNA as a model system. Spin-labeled RNA molecules were prepared by incorporating guanosine monophosphorothioate (GMPS) at the 5 end using T7 RNA polymerase and then cova
Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding.: RNA. 1999 Sep;5(9):1222-34. Unique Identifier : AIDSLINE MED/99424542; Jossinet F; Paillart JC; Westhof E; Hermann T; Skripkin E; Lodmell JS; Ehresmann C; Ehresmann B; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, Strasbourg, France.; Retroviruses encapsidate their genome as a dimer of homologous RNA molecules noncovalently linked close to their 5 ends. The dimerization initiation site (DIS) of human immunodeficiency virus type 1 (HIV-1) RNA is a hairpin structure that contains in the loop a 6-nt self-complementary sequence flanked by two 5 and o
[Prevalence of tuberculosis and HIV infections among participants in an intravenous drug user risk-control program]: Rev Esp Salud Publica. 1999 May-Jun;73(3):375-81. Unique Identifier : AIDSLINE MED/99409230; Alvarez Rodriguez M; Godoy Garcia P; Programa de reduccion de riesgos para UDVP, Servei Obert de; Lleida.; BACKGROUND: To determine the prevalence of tuberculosis and HIV infection in addition to the related factors among a population of participants in the risk control program in the town of Lleida. METHODS: The sample was comprised of the newly-enrolled participants in the program in April-June 1996, among whom a questio
Successful intrathecal ethanol block for intractable spasticity of AIDS-related progressive multifocal leukoencephalopathy.: Spinal Cord. 1999 Jun;37(6):450-2. Unique Identifier : AIDSLINE MED/99359225; Asensi V; Asensi JM; Carton JA; Maradona JA; Ona M; Arechaga C; Infectious Diseases Unit, Hospital Central de Asturias, Oviedo; University Medical School, Spain.; OBJECTIVE: To study the efficacy of intrathecal ethanol block to relieve intractable spasticity in AIDS-related progressive multifocal leukoencephalopathy (PML) when long-term intrathecal baclofen infusion cannot be used. METHODS: A 33-year-old man with AIDS-related PML developed very severe spastic paraparesis (Ashwo
Review: neuronal injury in HIV infection.: J Neurovirol. 1999 Aug;5(4):327-41. Unique Identifier : AIDSLINE MED/99391512; Petito CK; Kerza-Kwiatecki AP; Gendelman HE; McCarthy M; Nath A; Podack ER; Shapshak P; Wiley CA; Department of Pathology, Miami, Florida, USA.
Association of human herpesvirus 6 with the demyelinative lesions of progressive multifocal leukoencephalopathy.: J Neurovirol. 1999 Aug;5(4):363-73. Unique Identifier : AIDSLINE MED/99391515; Mock DJ; Powers JM; Goodman AD; Blumenthal SR; Ergin N; Baker JV; Mattson DH; Assouline JG; Bergey EJ; Chen B; Epstein LG; Blumberg BM; Department of Medicine/Infectious Diseases, University of; Rochester School of Medicine and Dentistry, NY 14642, USA.; Progressive Multifocal Leukoencephalopathy (PML) is a primary demyelinating disease of the central nervous system occurring almost exclusively in individuals with impaired cell-mediated immunity. The JC polyoma virus has been accepted as the etiologic agent ofPML. Using a two-step in-situ polymerase chain reaction pro
Prolonged survival without neurological improvement in patients with AIDS-related progressive multifocal leukoencephalopathy on potent combined antiretroviral therapy.: J Neurovirol. 1999 Aug;5(4):421-9. Unique Identifier : AIDSLINE MED/99391521; Gasnault J; Taoufik Y; Goujard C; Kousignian P; Abbed K; Boue F; Dussaix E; Delfraissy JF; Department of Internal Medicine, Hopital Universitaire de; Bicetre, Kremlin-Bicetre, France.; To evaluate the benefit of combined antiretroviral therapy including protease inhibitors (CART) on survival time and neurological progression in patients with AIDS-related progressive multifocal leukoencephalopathy (PML), 81 consecutive PML cases, collected between
Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals.: J Neurovirol. 1999 Aug;5(4):430-5. Unique Identifier : AIDSLINE MED/99391522; Koralnik IJ; Schmitz JE; Lifton MA; Forman MA; Letvin NL; Department of Neurology, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, Massachusetts 02215, USA.; While it has been suggested that JC virus (JCV) migrates in B-lymphocytes from the kidney to the central nervous system where it initiates demyelination, this phase of JCV pathogenesis has not been systematically explored. To determine the peripheral blood cell subpopulation(s) infected with JCV, monocytes, granulocyt
Tuberculosis acquired in laboratories and necropsy rooms.: Commun Dis Public Health. 1999 Sep;2(3):161-7. Unique Identifier : AIDSLINE MED/99420728; Collins CH; Grange JM; Imperial College School of Medicine, National Heart and Lung; Institute, London.; The resurgence of tuberculosis, and the increasing number of cases that are HIV-related and/or multidrug resistant, has renewed interest in the occupational hazards posed by tuberculosis to staff in laboratories and necropsy rooms. A search undertaken using Medline and Pre-Medline identified few comprehensive reviews:
Poor hepatitis B vaccine coverage in injecting drug users: England, 1995 and 1996 [see comments]: Commun Dis Public Health. 1999 Sep;2(3):174-7. Unique Identifier : AIDSLINE MED/99420730; Lamagni TL; Davison KL; Hope VD; Luutu JW; Newham JA; Parry JV; Gill ON; PHLS Communicable Disease Surveillance Centre, London.; tlamagni@phls.nhs.uk; Self-reported data on vaccination status collected in 1995 and 1996 from seven of the 39 drug agencies in England that took part in the unlinked anonymous HIV prevalence monitoring programme of injecting drug users were analysed to estimate hepatitis B vaccine coverage in this population. Twenty-seven per cent (374/13
Herpetic whitlow in an AIDS patient.: J Eur Acad Dermatol Venereol. 1999 May;12(3):241-2. Unique Identifier : AIDSLINE MED/99390746; Garcia-Plata MD; Moreno-Gimenez JC; Velez Garcia A; Valverde Blanco F; Fernandez Roldan JC; Seccion de Dermatologia del Hospital Universitario Reina; Sofia, Cordoba, Spain.; This case confirms that cutaneous herpes simplex virus (HSV) infections in many AIDS patients is important not only for the difficulty in diagnosis of herpetic lesions, but also for the possibility that co-infection by HSV and HIV can adversely affect prognosis in these patients.
Primary cutaneous Aspergillosis in a patient with acquired immunodeficiency syndrome [letter]: J Eur Acad Dermatol Venereol. 1999 May;12(3):268-70. Unique Identifier : AIDSLINE MED/99390755; Borbujo J; Jara M; Barros C; Amor E; Fortes D
Hepatitis C: epidemiology and review of complementary/alternative medicine treatments.: Altern Med Rev. 1999 Aug;4(4):220-38. Unique Identifier : AIDSLINE MED/99398870; Patrick L; Hepatitis C is emerging as a serious worldwide problem. In the United States the current mortality figures may triple in the next ten years, rivaling HIV. The disease has a latency of 10-30 years and symptoms or signs may not appear until cirrhosis is evident. Adequate diagnosis, inclu
Primary effusional lymphoma: A new non-Hodgkin s lymphoma entity.: Pathol Oncol Res. 1999;5(2):87-9. Unique Identifier : AIDSLINE MED/99322388; Matolcsy A; University Medical School of Pecs, Department of Pathology; Szigeti ut 12, Pecs, H-7624, Hungary. amatolc@pathology.pote.hu; A distinct non-Hodgkin s lymphoma (NHL) entity that grow in the body cavities as lymphomatous effusions in the absence of clinically identifiable tumor masses has been defined as primary effusional lymphoma (PEL). This lymphoma characterized by distinetive morphology, immunophenotype, genotype and association with Kap
Home parenteral nutrition: a transatlantic view [editorial; comment]: Clin Nutr. 1999 Jun;18(3):131-3. Unique Identifier : AIDSLINE MED/99388138; Howard L
Home parenteral nutrition in adults: a european multicentre survey in 1997. ESPEN-Home Artificial Nutrition Working Group [see comments]: Clin Nutr. 1999 Jun;18(3):135-40. Unique Identifier : AIDSLINE MED/99388139; Bakker H; Bozzetti F; Staun M; Leon-Sanz M; Hebuterne X; Pertkiewicz M; Shaffer J; Thul P; Department of Gastroenterology, Hopital Erasme, B1070 Bruxelles,; Belgium.; A retrospective survey on home parenteral nutrition (HPN) in Europe was performed from January to December 1997. Data were compared to a similar study performed in 1993. A questionnaire of HPN practice was designed by the members of the ESPEN-HAN group. This involved adult patients (older than 16 years) newly register
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.: Antivir Chem Chemother. 1999 Jul;10(4):211-7. Unique Identifier : AIDSLINE MED/99408616; Chimirri A; Grasso S; Monforte P; Rao A; Zappala M; Monforte AM; Pannecouque C; Witvrouw M; Balzarini J; De Clercq E; Dipartimento Farmaco-Chimico, Universita di Messina, Italy.; Using a known human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI), 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole (TBZ NSC 625487) as the lead structure for drug design, a series of novel 1H,3H-thiazolo[3,4-a]benzimidazole derivatives substituted on the benzene
Incidence of presumed cytomegalovirus retinitis in HIV-infected pediatric patients.: J Aapos. 1999 Aug;3(4):245-9. Unique Identifier : AIDSLINE MED/99404878; Du LT; Coats DK; Kline MW; Rosenblatt HM; Bohannon B; Contant CF Jr; Zhong YX; Brown B; Steinkuller PG; Paysse EA; Baylor College of Medicine, Texas Children's Hospital, Department; of Ophthalmology, USA.; INTRODUCTION: Large population studies of adult patients suggest an incidence of cytomegalovirus ( CMV ) retinitis as high as 19% to 20% as a late complication of adult HIV infection. We conducted this prospective study of a la
Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection [see comments]: Circ Res. 1999 Sep 17;85(6):551-8. Unique Identifier : AIDSLINE MED/99419308; Opavsky MA; Penninger J; Aitken K; Wen WH; Dawood F; Mak T; Liu P; Centre for Cardiovascular Research, The Toronto Hospital,; University of Toronto, Toronto, Ontario, Canada.; Viral myocarditis is an important cause of heart failure and dilated cardiomyopathy. T lymphocytes are implicated in myocardial damage in murine models of coxsackievirus B3 (CVB3) myocarditis. We used knockout mice lacking CD4 (CD4(-/-)), CD8 (CD8(-/-)), both coreceptors (CD4(-/-)CD8(-/-)), or the T-cell receptor beta
The immune system in viral myocarditis: maintaining the balance [editorial; comment]: Circ Res. 1999 Sep 17;85(6):559-61. Unique Identifier : AIDSLINE MED/99419309; Knowlton KU; Badorff C
Images in cardiovascular medicine. Fungal whip beats the heart.: Circulation. 1999 Sep 14;100(11):1249. Unique Identifier : AIDSLINE MED/99414138; Roman AR; Rodriguez-Bailon I; Gomez-Doblas JJ; Virgen de la Victoria University Hospital, Malaga, Spain.; megasevilla@interbook.net
A pilot study of low-dose fludarabine in membranous nephropathy refractory to therapy.: Clin Nephrol. 1999 Aug;52(2):67-75. Unique Identifier : AIDSLINE MED/99408093; Boumpas DT; Tassiulas IO; Fleisher TA; Vaughan E; Piscitelli S; Kim Y; Pucino F; Balow JE; Austin HA; Arthritis and Rheumatism Branch, National Institute of Arthritis; and Musculoskeletal and Skin Diseases, National Institutes of; Health, Bethesda, Maryland 20892, USA.; BACKGROUND: Lymphocytes are believed to play a role in the induction and perpetuation of membranous nephropathy. Fludarabine is a purine nucleoside analog with selective activity against both dividing and resting lymphocytes. We evaluated the tolerance, toxicity, pharmacokinetics, immunologic, and clinical effects of
Urinary stones [editorial; comment]: Curr Opin Urol. 1999 Jul;9(4):315-7. Unique Identifier : AIDSLINE MED/99388759; Marberger M
Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients.: Clin Pharmacokinet. 1999 Jul;37(1):75-86. Unique Identifier : AIDSLINE MED/99381091; Gieschke R; Fotteler B; Buss N; Steimer JL; F. Hoffmann-La Roche, Basel, Switzerland.; OBJECTIVE: The aim of this study was to confirm the most appropriate dosage of a new soft gelatin capsule (SGC) formulation of the HIV protease inhibitor saquinavir by investigating the relationships between systemic (plasma) exposure to saquinavir and plasma HIV RNA and CD4+ cell counts using empirical mathematical m
Giant cell arteritis can be associated with T4-lymphocytic alveolitis.: Clin Rheumatol. 1999;18(4):330-3. Unique Identifier : AIDSLINE MED/99396251; Blockmans D; Knockaert D; Bobbaers H; Department of General Internal Medicine, University Hospital; Gasthuisberg, Leuven, Belgium.; We describe three patients with histologically proven giant cell arteritis who presented with respiratory complaints. In one patient, dry cough and dyspnoea dominated the clinical picture. In the other two patients, a diagnosis of giant cell arteritis was readily suspected by the presence of typical complaints, althou
Efficacy and adverse effects of higher dose amphotericin B monotherapy for cryptococcal meningitis in patients with advanced HIV infection.: Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1998 Dec;31(4):233-9. Unique Identifier : AIDSLINE MED/99424483; Hsieh SM; Hung CC; Chen MY; Hsueh PR; Chang SC; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, ROC.; Treatment with a low daily dose of amphotericin B (0.4 mg/kg) in AIDS patients with cryptococcal meningitis has been associated with low efficacy and high mortality. We report our successful clinical experiences on a higher daily dose of amphotericin B (0.8-1.0 mg/kg) monotherapy in treating cryptococcal meningitis fr
[Clinical evaluation and immunomodulatory study of cefodizime]: Chung Hua Nei Ko Tsa Chih. 1997 Nov;36(11):759-63. Unique Identifier : AIDSLINE MED/99381257; Li G; Zhang Y; Ji M; Institute of Antibiotics, Shanghai Medical University.; To investigate the efficacy, safety and immunomodulating activities of cefodizime in immunocompromised patients with infections, we carried out a randomized controlled prospective study of cefodizime vs ceftizoxime in 107 patients. The total effective cure rate and bacterial eradication rate were 87.3%, 61.8% and 89.3
Disposition and biotransformation of the antiretroviral drug nevirapine in humans.: Drug Metab Dispos. 1999 Aug;27(8):895-901. Unique Identifier : AIDSLINE MED/99350239; Riska P; Lamson M; MacGregor T; Sabo J; Hattox S; Pav J; Keirns J; Department of Drug Metabolism and Pharmacokinetics, Boehringer; Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877,; USA. priska@rdg.boehringer-ingelheim.com; The pharmacokinetics and biotransformation of the antiretroviral agent nevirapine (NVP) after autoinduction were characterized in eight healthy male volunteers. Subjects received 200-mg NVP tablets once daily for 2 weeks, followed by 200 mg twice dail
Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction.: Drug Metab Dispos. 1999 Aug;27(8):902-8. Unique Identifier : AIDSLINE MED/99350240; Kumar GN; Dykstra J; Roberts EM; Jayanti VK; Hickman D; Uchic J; Yao Y; Surber B; Thomas S; Granneman GR; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064, USA.; ABT-378 is a potent in vitro inhibitor of the HIV protease and is currently being developed for coadministration with another HIV protease inhibitor, ritonavir, as an oral therapeutic treatment for HIV infection. In the present study, the effect of ritonavir, a potent inhibitor of cytochrome P-450 (CYP) 3A, on the in
Disposition of cosalane, a novel anti-HIV agent, in isolated perfused rat livers.: Drug Metab Dispos. 1999 Aug;27(8):947-50. Unique Identifier : AIDSLINE MED/99350247; Udata C; Mitra AK; Badr MZ; Division of Pharmaceutical Sciences, School of Pharmacy,; University of Missouri-Kansas City, Kansas City, Missouri; 64108-2792, USA.; Cosalane is a potent inhibitor of HIV replication with a broad range of activity. In this study, the hepatic disposition of cosalane was investigated with a noncirculating isolated perfused rat liver technique. When 6 microM cosalane was infused into livers from untreated rats, the drug was highly extracted by the liv
Liquid chromatography/mass spectrometry and high-field nuclear magnetic resonance characterization of novel mixed diconjugates of the non-nucleoside human immunodeficiency virus-1 reverse transcriptase inhibitor, efavirenz.: Drug Metab Dispos. 1999 Sep;27(9):1045-56. Unique Identifier : AIDSLINE MED/99391715; Mutlib AE; Chen H; Nemeth G; Gan LS; Christ DD; Drug Metabolism and Pharmacokinetics Section, DuPont; Pharmaceuticals Company, Stine-Haskell Research Center, Newark,; Delaware 19714, USA. abdul.mutlib@dupontpharma.com; Efavirenz ( Sustiva ) is a potent and specific inhibitor of the HIV-1 reverse transcriptase and is approved for the treatment of HIV infection. The metabolism of efavirenz in different
Modulation of rat cytochrome P-450 by an investigational HIV protease inhibitor.: Drug Metab Dispos. 1999 Sep;27(9):972-6. Unique Identifier : AIDSLINE MED/99391703; Nishime JA; Wang RW; Lin JH; Chiba M; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; Previous studies in vitro have revealed that L-754,394, an HIV protease inhibitor, is a potent suicide inhibitor of cytochrome P-450 enzymes. The present report examines the effect of chronic treatment of L-754,394 on hepatic cytochrome P-450s in adult male rats. L-754,394 was administered orally once a day for 7 days
Activated sulfonamides are cleaved by glutathione-S-transferases.: Drug Metab Dispos. 1999 Sep;27(9):986-91. Unique Identifier : AIDSLINE MED/99391706; Koeplinger KA; Zhao Z; Peterson T; Leone JW; Schwende FS; Heinrikson RL; Tomasselli AG; Protein Science, Pharmacia & Upjohn, Incorporated, Kalamazoo,; Michigan, USA.; In preclinical pharmacokinetic studies and in in vitro rat, dog, and human primary hepatocyte incubations, the sulfonamide (-NH-SO(2)-) bond of a potent inhibitor of the HIV-1 protease containing the p-cyanopyridinyl moiety (PNU-109112), undergoes metabolic cleavage to form the corresponding amine metabolite (PNU-1430
Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides.: Drug Metab Dispos. 1999 Sep;27(9):992-8. Unique Identifier : AIDSLINE MED/99391707; Zhao Z; Koeplinger KA; Peterson T; Conradi RA; Burton PS; Suarato A; Heinrikson RL; Tomasselli AG; Drug Metabolism, Pharmacia & Upjohn, Incorporated, Kalamazoo,; Michigan, USA.; The mechanism of sulfonamide cleavage of PNU-109112, a potent HIV-1 protease inhibitor, by glutathione-S-transferase (GST) was investigated in the presence of reduced GSH. GST-catalyzed sulfonamide cleavage takes place via the nucleophilic attack of GSH on the pyridine moiety of the substrate with formation of the GS-
Level of education and injecting drug use among African Americans.: Drug Alcohol Depend. 1999 Jun 1;55(1-2):177-82. Unique Identifier : AIDSLINE MED/99328612; Obot IS; Hubbard S; Anthony JC; Department of Mental Hygiene, School of Hygiene and Public; Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Drawing upon a nationally representative survey sample of African American (AA) drug injectors and non-injectors, this study tests for a suspected causal association between dropping out of school and the occurrence of injecting drug use (IDU), which remains a major cause of human immunodeficiency virus (HIV) transmis
Health-related service utilization and HIV risk behaviors among HIV infected injection drug users and crack smokers.: Drug Alcohol Depend. 1999 Jun 1;55(1-2):69-78. Unique Identifier : AIDSLINE MED/99328601; Booth RE; Kwiatkowski CF; Weissman G; Department of Psychiatry, University of Colorado School of; Medicine, Denver 80211, USA. boothr@uchsc.edu; This study was designed to assess utilization of health-related services and HIV risk related behaviors by HIV infected drug users one year prior to and two years following the availability of Ryan White Title I funding. Using a cross-sectional design, a total of 777 drug injectors and crack smokers from five US citie
Lamivudine. A review of its therapeutic potential in chronic hepatitis B.: Drugs. 1999 Jul;58(1):101-41. Unique Identifier : AIDSLINE MED/99368806; Jarvis B; Faulds D; Adis International Limited, Auckland, New Zealand.; demail@adis.co.nz; Lamivudine is a deoxycytidine analogue that is active against hepatitis B virus (HBV). In patients with chronic hepatitis B, lamivudine profoundly suppresses HBV replication. Clinically significant improvements in liver histology and biochemical param
Study of the aetiologic agents of meningitis in Kumasi, Ghana, with special reference to Cryptococcal neoformans.: East Afr Med J. 1998 Sep;75(9):516-9. Unique Identifier : AIDSLINE MED/99422721; Frimpong EH; Lartey RA; Department of Clinical Microbiology, School of Medical Sciences,; University of Science and Technology, Kumasi, Ghana.; OBJECTIVE: To evaluate the importance of Cryptococcus neoformans, an opportunistic in meningitis, in healthy and HIV infected patients in Kumasi, Ghana . DESIGN: A prospective study; isolating the aetiologic agents of meningitis from cerebrospinal fluid (CSF) using standard methods.
Chemoprophylaxis for tuberculosis in HIV-infected individuals in sub-Saharan Africa.: East Afr Med J. 1998 Sep;75(9):520-7. Unique Identifier : AIDSLINE MED/99422722; Nuwaha F; Department of Community Health, Mbarara University, Uganda.; OBJECTIVE: To examine the role of chemoprophylaxis as a public health strategy for the control of tuberculosis in sub-Saharan Africa. DATA SOURCES: Published literature regarding efficacy, cost-effectiveness and operational feasibility of chemoprophylaxis programmes. STUDY SELECTION: Studies mainly published from coun
Assessment of behavioural risk factors associated with HIV infection among youth in Moshi rural district, Tanzania.: East Afr Med J. 1998 Sep;75(9):528-32. Unique Identifier : AIDSLINE MED/99422723; Tengia-Kessy A; Msamanga GI; Moshiro CS; Department of Community Health, Muhimbili University College of; Health Sciences, Dar es Salaam, Tanzania.; To determine behavioural risk factors associated with human immunodeficiency virus (HIV) seropositivity among 1104 youth aged 15-24 years we conducted a cross-sectional survey in Moshi rural district in northern Tanzania . Information was obtained about sociodemographic characteri
Paediatric malignancies in Tanzania.: East Afr Med J. 1998 Sep;75(9):533-5. Unique Identifier : AIDSLINE MED/99422724; Carneiro PM; Kalokola FM; Kaaya EE; Department of Surgery, Muhimbili University College of Health; Sciences, Dar es Salaam, Tanzania.; Using the Tanzania Cancer Registry, the pattern of childhood malignancies up to the age of 15 years over a period of 22 years (1973-1995) was analysed. Lymphomas were most frequent (38.9%) followed by soft tissue sarcomas (13.1%), retinoblastomas (11.1%) and squamous cell carcino
A rapid method for determination of the relative copy number of HTLV-I proviral genome in HTLV-I carriers and adult T-cell leukemia patients by polymerase chain reaction.: Haematologia (Budap). 1999;29(4):265-76. Unique Identifier : AIDSLINE MED/99364777; Hori T; Kikuchi H; Ohtsuka E; Ono K; Saburi Y; Nasu M; The Second Department of Internal Medicine, Oita Medical; University, Hasama-machi, Japan.; Ten adult T-cell leukemia (ATL) patients and 11 asymptomatic human T-cell leukemia virus type I (HTLV-I) carriers were examined by polymerase chain reaction (PCR) assay with a reduced sensitivity to evaluate its utility in detecting the relative copy number of the HTLV-I genome in clinical samples. Differences in the
[Use of flow cytometry in evaluation of cellular changes in interstitial lung diseases]: Folia Med Cracov. 1997;38(3-4):69-115. Unique Identifier : AIDSLINE MED/99410998; Kopinski P; Zaklad Patofizjologii Klinicznej Katedra Patofizjologii Collegium; Medicum UJ.; Flow cytometry (FC) usefulness for pulmonary reactive cell changes examination in interstitial lung diseases was assessed. Bronchoalveolar lavage (BAL) lymphocyte direct (two-color and three-color) phenotyping was carried out in 63 patients with sarcoidosis (subdivided according to the disease radiological stage and s
Relative abilities of 4-1BB (CD137) and CD28 to co-stimulate the response of cytokine deflected Th1 and Th2 cells.: Immunobiology. 1999 Jun;200(2):246-63. Unique Identifier : AIDSLINE MED/99344621; Vinay DS; Kwon BS; Department of Microbiology and Immunology, Indiana University; School of Medicine and Walther Oncology Center, Indianapolis,; USA.; In this report we show that allo-stimulated naive CD4+ cells when cultured in IL-2 , IFN-gamma, IL-12 and anti-IL-4 differentiated into Th1 cells expressing very low amounts of 4-1BB molecule, but high amounts of CD28. By contrast, allo-stimulated naive CD4+ cells cultu
Oral tolerance by a high dose OVA in BALB/c mice is more pronounced and persistent in Th2-mediated immune responses than in Th1 responses.: Immunobiology. 1999 Jun;200(2):264-76. Unique Identifier : AIDSLINE MED/99344622; Kang B; Kim KM; Kang CY; Laboratory of Immunology, College of Pharmacy, Seoul National; University, Korea.; Oral administration of antigen induces an antigen-specific immunologic tolerance and many studies are being carried out to apply this phenomenon to the treatment of autoimmune diseases. In this study, we investigated long-term Th1 and Th2 tolerance in mice given a high dose of orally administered Ovalbumin (OVA). Feed
Early rheumatoid arthritis is associated with diminished numbers of TH1 cells in stimulated peripheral blood.: Immunobiology. 1999 Jun;200(2):290-4. Unique Identifier : AIDSLINE MED/99344624; Mangge H; Felsner P; Herrmann J; el-Shabrawi Y; Liebmann P; Schauenstein K; Department of Laboratory Medicine (Blocklabor III), University of; Graz, School of Medicine, Austria. harald.mangge@kfunigraz.ac.at; Rheumatoid arthritis (RA) has been associated with an altered TH1/TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokines. A group of 10 patients suffering from initial stage
Longitudinal study of antibody reactivity against HIV-1 envelope and a peptide representing a conserved site on Gp41 in HIV-1-infected patients.: Immunobiology. 1999 Jun;200(2):295-305. Unique Identifier : AIDSLINE MED/99344625; Muhlbacher M; Spruth M; Siegel F; Zangerle R; Dierich MP; Institut fur Hygiene, Universitat Innsbruck, Austria.; This study was designed to distinguish between antibodies in HIV-1-infected patients directed against epitopes accessible on the native HIV-1 envelope (Env) complex and non-native Env epitopes. Peptide p#13 (Env. aa642-673) containing the neutralising 2F5 epitope and recombinant soluble glycoprotein 160 (rsgp160) were
Characterization of the memory/activated T cells that mediate the long-lived host response against tuberculosis after bacillus Calmette-Guerin or DNA vaccination.: Immunology. 1999 Aug;97(4):573-81. Unique Identifier : AIDSLINE MED/99388387; Silva CL; Bonato VL; Lima VM; Faccioli LH; Leao SC; Department of Parasitology, Microbiology and Immunology, School; of Medicine of Ribeirao Preto, University of Sao Paulo.; The memory/activated T cells, which mediate the long-lived host response against tuberculosis, in mice immunized with either bacillus Calmette-Guerin (BCG) or mycobacterium heat-shock protein 65 (hsp 65) antigen expressed from plasmid DNA (DNA-hsp 65), were characterized. Protection against Mycobacterium tuberculosis
Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses.: Immunology. 1999 Aug;97(4):588-94. Unique Identifier : AIDSLINE MED/99388389; Mountford AP; Coulson PS; Cheever AW; Sher A; Wilson RA; Wynn TA; Department of Biology, The University of York, York, UK.; An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated as an environment in which to analyse a role for interleukin-12 (IL-12) in the differentiation of T-helper 1 (Th1) and Th2 subsets. Specifically, mice deficient for the interferon-gamma receptor (IFN-gammaR-/-) were us
A bone marrow-derived stroma cell line, ST2, can support the differentiation of fetal thymocytes from the CD4+ CD8+ double negative to the CD4+ CD8+ double positive differentiation stage in vitro.: Immunology. 1999 Aug;97(4):672-8. Unique Identifier : AIDSLINE MED/99388400; Tong J; Kishi H; Matsuda T; Muraguchi A; Department of Immunology, Faculty of Medicine, Toyama Medical and; Pharmaceutical University, Sugitani, Toyama, Japan.; T-cell precursors differentiate into mature T cells predominantly in the thymus. However, it has also been reported that T-cell precursors mature in extrathymic organs such as the liver, bone marrow, or intestines. In order to investigate the nature of the extrathymic microenvironment that supports T-cell maturation,
Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen.: Immunology. 1999 Aug;97(4):679-85. Unique Identifier : AIDSLINE MED/99388401; Roberts AI; Brolin RE; Ebert EC; Department of Medicine, Robert Wood Johnson Medical School, New; Brunswick, NY, USA.; Intraepithelial lymphocytes (IELs) from human intestinal epithelium are memory CD8+ T cells that bind to epithelial cells through human mycosal lymphocyte (HML)-1 and to mesenchymal cells through very late activation antigen-4 (VLA-4). Their binding of extracellular matrix proteins and the mechanism involved were test
Seroprevalence of HIV infection among jail inmates in Orissa.: Indian J Med Res. 1999 Jun;109:199-201. Unique Identifier : AIDSLINE MED/99420769; Pal BB; Acharya AS; Satyanarayana K; Clinical Pathology and Microbiology Division, Regional Medical; Research C (ICMR), Chandrasekharpur, Bhubaneswar.; Seroprevalence of human immunodeficiency virus (HIV) infection was carried out in three prisons in Orissa from March 1994 to December 1995. All the prisoners of Indian origin (300), housed in these jails tested negative for HIV infection. On the other hand, 33.8 per cent (26/77) of jail inmates from foreign countries
Identification of amino acid residues of the T-cell epitope of Mycobacterium tuberculosis alpha antigen critical for Vbeta11(+) Th1 cells.: Infect Immun. 1999 Sep;67(9):4312-9. Unique Identifier : AIDSLINE MED/99386814; Kariyone A; Higuchi K; Yamamoto S; Nagasaka-Kametaka A; Harada M; Takahashi A; Harada N; Ogasawara K; Takatsu K; Department of Immunology, Institute of Medical Science,; University of Tokyo, Minato-ku, Japan.; Stimulation of Mycobacterium tuberculosis-primed lymph node cells from C57BL/6 mice with alpha antigen (also known as antigen 85B and MPT59) induced cell proliferation, production of interleukin 2 and gamma interferon, and expansion of Vbeta11(+) CD4(+) T cells in conjunction with antigen-presenting cells in an I-A(b)
Down-regulation of Th2 responses by Brucella abortus, a strong Th1 stimulus, correlates with alterations in the B7.2-CD28 pathway.: Infect Immun. 1999 Sep;67(9):4418-26. Unique Identifier : AIDSLINE MED/99386828; Agranovich I; Scott DE; Terle D; Lee K; Golding B; Laboratory of Plasma Derivatives, Division of Hematology, Center; for Biologics Evaluation and Research, U.S. Food and Drug; Administration, Bethesda, Maryland 20852, USA.; Down-regulation of the Th2-like response induced by ovalbumin-alum (OVA/alum) immunization by heat-killed Brucella abortus was not reversed by anti-IL-12 antibody treatment or in gamma interferon (IFN-gamma) knockout mice, suggesting that induction of Th1 cytokines was not the only mechanism involved in the B. abortus
Role of Mycoplasma penetrans endonuclease P40 as a potential pathogenic determinant.: Unique Identifier : AIDSLINE MED/99386832; Bendjennat M; Blanchard A; Loutfi M; Montagnier L; Bahraoui E; Laboratory of Immunovirology UFR SVT, University of Paul; Sabatier, 31062 Toulouse, France.; Recently, we reported the purification to homogeneity and characterization of Ca(2+)- and Mg(2+)-dependent endonuclease P40 produced by Mycoplasma penetrans (M. Bendjennat, A. Blanchard, M. Loutfi, L. Montagnier, and E. Bahraoui, J. Bacteriol. 179; 2210-2220, 1997), a mycoplasma which was isolated for the first time f
Polarization of the immune response to the single immunodominant epitope of p38, a major Schistosoma mansoni egg antigen, generates Th1- or Th2-type cytokines and granulomas.: Infect Immun. 1999 Sep;67(9):4570-7. Unique Identifier : AIDSLINE MED/99386848; Chen Y; Boros DL; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; In schistosomiasis mansoni, helminth eggs secrete soluble egg antigens (SEA) that induce T-cell-mediated granulomatous tissue responses. The cloned 38-kDa peptide (p38) of SEA was shown to induce and elicit Th1-type responsiveness in H-2(k) mice. Subsequently, the immunodominant T-cell epitope (P4) of p38 was shown to
Immunization of mice with a TolA-like surface protein of Trypanosoma cruzi generates CD4(+) T-cell-dependent parasiticidal activity.: Infect Immun. 1999 Sep;67(9):4603-12. Unique Identifier : AIDSLINE GENBANK/AF099099; Quanquin NM; Galaviz C; Fouts DL; Wrightsman RA; Manning JE; Department of Molecular Biology and Biochemistry, University of; California, Irvine, California 92697-3900, USA.; The gene family encoding a trypomastigote-specific protein restricted to the part of the flagellum in contact with the cell body of the trypomastigote form of Trypanosoma cruzi has been isolated, characterized, and expressed in a baculovirus expression system. The gene family contains three tandemly repeated members t
Genetic control of schistosome infections by the SM1 locus of the 5q31-q33 region is linked to differentiation of type 2 helper T lymphocytes.: Infect Immun. 1999 Sep;67(9):4689-92. Unique Identifier : AIDSLINE MED/99386863; Rodrigues V Jr; Piper K; Couissinier-Paris P; Bacelar O; Dessein H; Dessein AJ; Laboratorio de Imunologia, Faculdade de Medicina do Triangulo; Mineiro, 30, Frei Paulino, 38025-160, Uberaba, MG, Brazil.; Human susceptibility to Schistosoma mansoni infections is controlled by the SM1 locus on chromosome 5 in q31-q33. This genetic region encodes cytokines which regulate the development of helper T lymphocytes. In the present work, a clonal analysis of CD4(+) T lymphocytes of homozygous resistant and homozygous susceptib
Observed differences in virulence-associated phenotypes between a human clinical isolate and a veterinary isolate of Mycobacterium avium.: Infect Immun. 1999 Sep;67(9):4895-901. Unique Identifier : AIDSLINE MED/99386892; Birkness KA; Swords WE; Huang PH; White EH; Dezzutti CS; Lal RB; Quinn FD; Division of AIDS, STD and TB Laboratory Research, National Center; for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Mycobacterium avium, the most common opportunistic pathogen in patients with AIDS, is frequently isolated from a variety of environmental sources, but rarely can these environmental isolates be epidemiologically linked with isolates known to cause human disease. Using a number of in vitro tissue culture assays, we fou
Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB/c mice infected with Leishmania major.: Infect Immun. 1999 Sep;67(9):4939-44. Unique Identifier : AIDSLINE MED/99386901; Santiago HC; Oliveira MA; Bambirra EA; Faria AM; Afonso LC; Vieira LQ; Gazzinelli RT; Department of Biochemistry and Immunology-ICB, Federal University; of Minas Gerais, 31270-910 Belo Horizonte, Brazil.; Lesion size, cellular infiltration, and tissue parasitism in the footpads of BALB/c mice infected with Leishmania major were all dramatically inhibited during acute but not chronic infection with Toxoplasma gondii. Similarly, acute but not chronic toxoplasmosis at the time of infection with L. major had a strong inhib
Lymphocyte subsets in conjunctival mucosa-associated-lymphoid-tissue after exposure to retinal-S-antigen.: Int Ophthalmol. 1998-99;22(2):77-80. Unique Identifier : AIDSLINE MED/99399744; Gormley PD; Powell-Richards AO; Azuara-Blanco A; Donoso LA; Dua HS; Larry A. Donoso Laboratory for Eye Research, Queen's Medical; Centre, University Hospital, Nottingham, UK.; PURPOSE: To evaluate the immune cell subsets in conjunctival mucosa-associated-lymphoid-tissue (C-MALT) following challenge with antigen. METHODS: Ten adult female Lewis rats were studied. Five rats received one drop (5 microL) of retinal S-antigen (500 microg/mL in phosphate buffered saline, PBS) instilled into the l
T-cell-mediated immune responses in alloepithelial rejection after murine keratoepithelioplasty.: Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2590-7. Unique Identifier : AIDSLINE MED/99437353; Miyazaki D; Inoue Y; Yao YF; Okada AA; Shimomura Y; Hayashi K; Tano Y; Ohashi Y; Department of Ophthalmology, Osaka University Medical School,; Suita, Japan.; PURPOSE: To evaluate the role of delayed-type hypersensitivity (DTH) and cytotoxic T-lymphocyte (CTL) responses on alloepithelial rejection in a murine keratoepithelioplasty model. METHODS: C3H/He mouse corneal lenticules were grafted around the limbus in BALB/c mice, and alloepithelial rejection was assessed by micro
Protection against murine cytomegalovirus retinitis by adoptive transfer of virus-specific CD8+ T cells.: Unique Identifier : AIDSLINE MED/99437355; Bigger JE; Tanigawa M; Thomas CA 3rd; Atherton SS; PURPOSE: Human cytomegalovirus retinitis, the most common ophthalmic infection of AIDS patients, has been modeled in BALB/c mice infected with murine cytomegalovirus by the supraciliary route. A series of depletion and adoptive transfer studies was performed to determine whether ad
Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice.: Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2614-21. Unique Identifier : AIDSLINE MED/99437356; Yamada J; Kurimoto I; Streilein JW; Kyoto Prefectural University, Japan.; PURPOSE: To determine, with the use of mice genetically deficient in expression of CD4 or CD8 molecules, which T cells are responsible for rejection of orthotopic corneal allografts in mice. METHODS: Corneas were prepared from major histocompatibility complex (MHC)-only incompatible, minor histocompatibility (H)- only
An immunohistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese diabetic (NOD) mice during disease acceleration with cyclophosphamide.: Histochem J. 1999 May;31(5):303-14. Unique Identifier : AIDSLINE MED/99388961; Reddy S; Yip S; Karanam M; Poole CA; Ross JM; Department of Paediatrics, University of Auckland School of; Medicine, New Zealand.; Cyclophosphamide has been used to accelerate and synchronize diabetes in non-obese diabetic (NOD) mice. It was injected to 70-day-old female NOD mice and its effect on the progression of insulitis studied at days 0, 4, 7, 11 and at onset of diabetes. Pancreatic sections were also examined for the influx of CD4 and CD8
The human uniqueness of HIV: innate immunity and the viral Tat protein.: Hum Immunol. 1999 Aug;60(8):631-9. Unique Identifier : AIDSLINE MED/99368164; Rodman TC; Sullivan JJ; Bai X; Winston R; Laboratory of Bacterial Pathogenesis, Rockefeller University, New; York, NY 10021, USA.; We have previously reported, and confirm here, that the human innate system of natural antibodies includes two, each of which is reactive, presumably by happenstance, with a specific sequence of HIV Tat protein. Comparison of cohorts of HIV+ and normal (HIV-) sera indicate that, following a period of post-infection la
CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.: Hum Immunol. 1999 Aug;60(8):652-64. Unique Identifier : AIDSLINE MED/99368166; Ou D; Jonsen LA; Metzger DL; Tingle AJ; Department of Paediatrics, Faculty of Medicine, University of; British Columbia, Vancouver, Canada.; To fully characterize human glutamic acid decarboxylase (GAD)65 protein T-cell epitopes associated with insulin-dependent diabetes mellitus (IDDM), CTL clones specific to GAD65 protein antigens were isolated from two congenital rubella syndrome (CRS)-associated IDDM patients. Overlapping nonamer T-cell epitopes recogn
Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis.: Hum Immunol. 1999 Aug;60(8):677-87. Unique Identifier : AIDSLINE MED/99368168; Yacyshyn B; Maksymowych W; Bowen-Yacyshyn MB; Department of Medicine, University of Alberta, Edmonton, Canada.; bruce.yacyshyn@ualberta.ca; The clinical benefit of Cyclosporine A (CsA) in IBD is controversial. Drugs including CsA are substrates of the P-glycoprotein-170 (Pgp-170) cell surface pump. Although the mechanism of action of CsA is complex, we determined that Pgp-170 might be expressed differentially between these two diseases. Intra-epithelial,
Benign parotid hypertrophy on +HIV patients: limited late failures after external radiation.: Int J Radiat Oncol Biol Phys. 1999 Sep 1;45(2):451-5. Unique Identifier : AIDSLINE MED/99415511; Beitler JJ; Smith RV; Brook A; Edelman M; Sharma A; Serrano M; Silver CE; Davis LW; Department of Radiation Oncology, Montefiore Medical Center,; Bronx, NY, USA. JBeitler92@alumni.gsb.columbia.edu; PURPOSE: Although 8-10 Gy of external radiation therapy for +HIV associated parotid hypertrophy has achieved high response rates, the responses were transient with only 1/12 of patients retaining cosmetic control at median follow-up procedures of 9.5 months. Retreatment for failures after 8-10 Gy has also been unsatis
The role of splenic irradiation in treating HIV-associated immune thrombocytopenia.: Int J Radiat Oncol Biol Phys. 1999 Sep 1;45(2):457-60. Unique Identifier : AIDSLINE MED/99415512; Blauth J; Fisher S; Henry D; Nichini F; Department of Radiation Oncology, Graduate Hospital,; Philadelphia, PA, USA.; PURPOSE: To evaluate our experience in treating patients with HIV-associated thrombocytopenia using splenic irradiation. METHODS AND MATERIALS: From 1993 to 1998, 10 patients with HIV-related immune thrombocytopenia (ITP) were treated in our department with low-dose splenic irradiation. All patients had either failed
Healthy pets, healthy people.: J Am Vet Med Assoc. 1999 Aug 1;215(3):335-8. Unique Identifier : AIDSLINE MED/99363827; Wong SK; Feinstein LH; Heidmann P; School of Veterinary Medicine, Tufts University, North Grafton,; Mass. 01536, USA.; Zoonoses, diseases that can be transmitted from animals to humans, can pose serious health risks to immunocompromised people. Although pets can carry zoonoses, owning and caring for animals can benefit human health. Information exists about preventing transmission of zoonoses, but not all physicians and veterinarians
The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells.: J Biol Chem. 1999 Sep 10;274(37):26259-65. Unique Identifier : AIDSLINE MED/99403069; Campbell NA; Kim HS; Blumberg RS; Mayer L; Division of Clinical Immunology, Mount Sinai Medical Center, New; York, New York 10029, USA. nicola@gene.com; Previous studies have shown that normal intestinal epithelial cells (IECs) are able to selectively activate CD8(+) T cells with suppressor activity, inducing proliferation associated with the activation of both the CD8-associated kinase p56(lck) and the T cell receptor (TCR)-associated kinase p59(fyn). This process ap
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.: J Biol Chem. 1999 Sep 10;274(37):26321-8. Unique Identifier : AIDSLINE MED/99403077; Van Orden K; Giebler HA; Lemasson I; Gonzales M; Nyborg JK; Department of Biochemistry and Molecular Biology, Colorado State; University, Fort Collins, Colorado 80523-1870, USA.; The pleiotropic cellular coactivator CREB binding protein (CBP) plays a critical role in supporting p53-dependent tumor suppressor functions. p53 has been shown to directly interact with a carboxyl-terminal region of CBP for recruitment of the coactivator to p53-responsive genes. In this report, we identify the KIX do
Soluble Rous sarcoma virus reverse transcriptases alpha, alphabeta, and beta purified from insect cells are processive DNA polymerases that lack an RNase H 3' --> 5' directed processing activity.: J Biol Chem. 1999 Sep 10;274(37):26329-36. Unique Identifier : AIDSLINE MED/99403078; Werner S; Wohrl BM; Max-Planck-Institut fur molekulare Physiologie, Abteilung; Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund,; Germany.; Reverse transcriptase (RT) isolated from Rous sarcoma virus (RSV) consists of heterodimeric RTalphabeta, RTalpha, and RTbeta. The alpha subunit (63 kDa) contains an N-terminal polymerase and a C-terminal RNase H domain. The N terminus of beta (95 kDa) corresponds to alpha with the integrase domain attached to the C te
SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.: J Biol Chem. 1999 Sep 10;274(37):26579-83. Unique Identifier : AIDSLINE MED/99403111; Briggs SD; Smithgall TE; Eppley Institute for Research in Cancer and the Department of; Pathology and Microbiology, University of Nebraska Medical; Center, Omaha, Nebraska 68198, USA.; Biochemical and structural studies of Src and related kinases demonstrate that two intramolecular interactions suppress kinase activity. These interactions involve binding of the SH2 domain to a phosphotyrosine residue in the C-terminal tail and association of the SH3 domain with a polyproline type II helix formed by
Evaluation of new quantitative assays for diagnosis and monitoring of cytomegalovirus disease in human immunodeficiency virus-positive patients.: J Clin Microbiol. 1999 Oct;37(10):3124-32. Unique Identifier : AIDSLINE MED/99419127; Pellegrin I; Garrigue I; Binquet C; Chene G; Neau D; Bonot P; Bonnet F; Fleury H; Pellegrin JL; Laboratoire de Virologie, Centre Hospitalier Regional et; Universite Victor Segalen, Bordeaux, France.; isabelle.pellegrin@chu-aquitaine.fr; Cobas Amplicor CMV Monitor (CMM) and Quantiplex CMV bDNA 2.0 (CMV bDNA 2.0), two new standardized and quantitative assays for the detection of cytomegalovirus (CMV) DNA in plasma and peripheral blood leukocytes (PBLs), respec
Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine.: J Clin Microbiol. 1999 Oct;37(10):3338-47. Unique Identifier : AIDSLINE MED/99419164; Allen MI; Gauthier J; DesLauriers M; Bourne EJ; Carrick KM; Baldanti F; Ross LL; Lutz MW; Condreay LD; Department of Virology, Inc., Research Triangle Park, North; Carolina 27709-3398, USA. mia46935@glaxowellcome.com; Two novel assays, a restriction fragment length polymorphism (RFLP) assay and an assay based on the 5 -nuclease activity of Taq DNA polymerase, were developed for screening viral variants in lamivudine-treated patients sera containing
Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis.: J Clin Microbiol. 1999 Oct;37(10):3405-8. Unique Identifier : AIDSLINE MED/99419182; Muller FM; Kasai M; Francesconi A; Brillante B; Roden M; Peter J; Chanock SJ; Walsh TJ; Immunocompromised Host Section, Pediatric Oncology Branch,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892, USA. fmmueller@mail.uni-wuerzberg.de; We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecul
Natural history of intestinal microsporidiosis among patients infected with human immunodeficiency virus.: J Clin Microbiol. 1999 Oct;37(10):3421-2. Unique Identifier : AIDSLINE MED/99419187; Dascomb K; Clark R; Aberg J; Pulvirenti J; Hewitt RG; Kissinger P; Didier ES; LSU School of Medicine, Tulane School of Public Health and; Tropical Medicine, New Orleans, Louisiana, USA.; A chart review of 73 human immunodeficiency virus (HIV)-infected patients with enteric microsporidiosis was conducted to define the natural history of microsporidiosis. A substantial proportion of patients remained symptomatic after 6 months (54.8% with persistent diar
T cell response to myelin basic protein before and after treatment with interferon beta in multiple sclerosis.: J Neuroimmunol. 1999 Sep 1;99(1):91-6. Unique Identifier : AIDSLINE MED/99424500; Ristori G; Montesperelli C; Gasperini C; Battistini L; Borsellino G; Buttinelli C; Cannoni S; Perna A; Pozzilli C; Salvetti M; Department of Neurological Sciences, Universita La Sapienza,; Rome, Italy. md0914@mclink.it; Studies on the in vivo effects of interferon-beta (IFNbeta) therapy on autoreactive T cells have never been carried out in multiple sclerosis (MS). We investigated the T cell response to myelin basic protein (MBP), before and after IFN-beta therapy, raising MBP-specific T cell lines (TCL) from the peripheral blood of
Effect of staphylococcal enterotoxin B injection on the development of experimental autoimmune encephalomyelitis: influence of cytokine and inducible nitric oxide synthase production.: J Neuroimmunol. 1999 Oct 29;99(2):157-68. Unique Identifier : AIDSLINE MED/99433789; Kuschnaroff LM; Overbergh L; Sefriouni H; Sobis H; Vandeputte M; Waer M; Laboratory for Experimental Transplantation and Rega Institute,; University of Leuven, Belgium.; Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of Vbeta8 + T-lymphocytes were documented after myelin basic protein immuniza
Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis.: J Neuroimmunol. 1999 Oct 29;99(2):173-82. Unique Identifier : AIDSLINE MED/99433791; Clerici M; Fusi ML; Caputo D; Guerini FR; Trabattoni D; Salvaggio A; Cazzullo CL; Arienti D; Villa ML; Urnovitz HB; Ferrante P; Cattedra di Immunologia, Universita degli Studi di Milano,; Padiglione LITA, Ospedale L. Sacco, Milan, Italy.; mago@imiucca.csi.unimi.it; A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral bloo
Vascular cell adhesion molecule-1-mediated matrix metalloproteinase-2 induction in peripheral blood T cells is up-regulated in patients with HTLV-I-associated myelopathy.: J Neuroimmunol. 1999 Oct 29;99(2):242-7. Unique Identifier : AIDSLINE MED/99433800; Kambara C; Nakamura T; Furuya T; Migita K; Ida H; Kawakami A; Shirabe S; Nakane S; Kinoshita I; Eguchi K; First Department of Internal Medicine, Nagasaki University School; of Medicine, Sakamoto, Japan.; We investigated whether matrix metalloproteinase-2 (MMP-2) is induced in peripheral blood T cells after their contact with tumor necrosis factor-alpha (TNF-alpha)-stimulated glioblastoma cell line (T98G), expressing vascular cell adhesion molecule-1 (VCAM-1), in patients with HTLV-I-associated myelopathy (HAM) compare
Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo [see comments]: J Clin Invest. 1999 Sep;104(5):R7-R11. Unique Identifier : AIDSLINE MED/99417705; Glushakova S; Yi Y; Grivel JC; Singh A; Schols D; De Clercq E; Collman RG; Margolis L; Laboratory of Molecular and Cellular Biophysics, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Many HIV-1 isolates at the late stage of disease are capable of using both CXCR4 and CCR5 in transfected cell lines, and are thus termed dual-tropic. Here we asked whether these dual-tropic variants also use both coreceptors for productive infection in a natural human lymphoid tissue microenvironment, and whether use
The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis [comment]: J Clin Invest. 1999 Sep;104(5):527-9. Unique Identifier : AIDSLINE MED/99417689; Hafler DA; Harvard Medical School and Brigham and Women's Hospital, Harvard; Institutes of Medicine, 77 Avenue Louis Pasteur, Boston,; Massachusetts 02115, USA.
Physiological coreceptor use by dual-tropic HIV-1: one plus one equals one [comment]: J Clin Invest. 1999 Sep;104(5):531-2. Unique Identifier : AIDSLINE MED/99417690; Rollins BJ; Department of Adult Oncology, Dana-Farber Cancer Institute,; Boston Massachusetts 02115, USA. barrett_rollins@dfci.harvard.edu
Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice [see comments]: J Clin Invest. 1999 Sep;104(5):599-610. Unique Identifier : AIDSLINE MED/99417698; Katz-Levy Y; Neville KL; Girvin AM; Vanderlugt CL; Pope JG; Tan LJ; Miller SD; Department of Microbiology-Immunology and Interdepartmental; Immunobiology Center, Northwestern University Medical School,; Chicago, Illinois 60611, USA.; The mechanisms underlying the initiation of virus-induced autoimmune disease are not well understood. Theiler s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a mouse model of multiple sclerosis, is initiated by TMEV-specific CD4(+) T cells targeting virally infected central nervous system-re
Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells.: J Clin Invest. 1999 Sep;104(5):611-8. Unique Identifier : AIDSLINE MED/99417699; Fenard D; Lambeau G; Valentin E; Lefebvre JC; Lazdunski M; Doglio A; Laboratoire de Virologie, Faculte de Medecine, 06107 Nice; cedex 2, France Institut de Pharmacologie Moleculaire et; Cellulaire, 06560 Valbonne, France.; Mammalian and venom secreted phospholipases A(2) (sPLA(2)s) have been associated with a variety of biological effects. Here we show that several sPLA(2)s protect human primary blood leukocytes from the replication of various macrophage and T cell-tropic HIV-1 strains. Inhibition by sPLA(2)s results neither from a viru
Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle.: J Clin Invest. 1999 Sep;104(5):657-67. Unique Identifier : AIDSLINE MED/99417704; Hakonarson H; Maskeri N; Carter C; Chuang S; Grunstein MM; Division of Pulmonary Medicine, Joseph Stokes, Jr. Research; Institute, The Children's Hospital of Philadelphia, University of; Pennsylvania School of Medicine, Philadelphia, Pennsylvania; 19104, USA.; T-helper type 2 (Th2) cytokines have been implicated in the pathogenesis of the pulmonary inflammatory response and altered bronchial responsiveness in allergic asthma. To elucidate the mechanism of Th2-dependent mediation of altered airway responsiveness in the atopic asthmatic state, the expression and actions of sp
The effects of partner insistence of condom usage on perceptions of the partner, the relationship, and the experience.: J Adolesc. 1999 Jun;22(3):355-67. Unique Identifier : AIDSLINE MED/99393565; Hocking JE; Turk D; Ellinger A; Department of Speech Communication, University of Georgia, Athens; 30602-1725, USA.; The present study examined the effects of an individual insisting on condom usage on how he or she is viewed by their partner. Participants were led through a realistic role-play scenario in which, after dating a new partner for a while , they engaged in sexual intercourse. Results were such that after first time sex
Shifts in bovine CD4+ subpopulations increase T-helper-2 compared with T-helper-1 effector cells during the postpartum period.: J Dairy Sci. 1999 Aug;82(8):1696-706. Unique Identifier : AIDSLINE MED/99409464; Shafer-Weaver KA; Corl CM; Sordillo LM; Department of Veterinary Science, Pennsylvania State University,; University Park 16802, USA.; This study determined the cytokine profile of CD4+ T-helper cells to elucidate the specific CD4+ T-helper phenotype during the postpartum period. Peripheral blood mononuclear cells were isolated from cows during periods of increased susceptibility (3 d postpartum, n = 7) and decreased susceptibility (mid- to late lact
The prognostic factors of cryptococcal meningitis in HIV-negative patients.: J Hosp Infect. 1999 Aug;42(4):313-20. Unique Identifier : AIDSLINE MED/99396876; Lu CH; Chang WN; Chang HW; Chuang YC; Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung,; Taiwan.; Seventy-one patients with cryptococcal meningitis, 46 males and 25 females, aged 15-83 years, were included in this study. Their initial clinical manifestations, cerebrospinal fluid (CSF) features, and therapeutic results were analysed. Patients were treated with three different regimens: amphotericin B, fluconazole,
Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4.: J Immunol. 1999 Sep 15;163(6):2977-81. Unique Identifier : AIDSLINE MED/99406783; Bresnahan PA; Yonemoto W; Greene WC; Gladstone Institute of Virology, Department of Medicine,; University of California, San Francisco 94141, USA.; The Nef protein is unique to primate lentiviruses and is closely linked to accelerated pathogenesis in both human and monkey hosts. Nef acts to down-regulate CD4 and MHC class I, two receptors important for immune function. A recent report demonstrated the presence of two tyrosine motifs in SIV Nef that contribute to
A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat.: J Immunol. 1999 Sep 15;163(6):2983-9. Unique Identifier : AIDSLINE MED/99406784; Damoiseaux JG; Cautain B; Bernard I; Mas M; van Breda Vriesman PJ; Druet P; Fournie G; Saoudi A; Department of Internal Medicine, Section Immunology, University; Maastricht, The Netherlands. jgmc.damoiseaux@immuno.unimaas.nl; During their development, immature CD4CD8 double positive thymocytes become committed to either the CD4 or CD8 lineage. The final size of the peripheral CD4 and CD8 T cell compartments depends on thymic output and on the differential survival and proliferation of the respective T cell subsets in the periphery. Our res
Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.: J Immunol. 1999 Sep 15;163(6):2999-3006. Unique Identifier : AIDSLINE MED/99406786; Krummel MF; Heath WR; Allison J; The Walter and Eliza Hall Institute, Royal Melbourne Hospital,; Parkville, Australia. krummel@cmgm.stanford.edu; The role of second signals delivered through B7/CD28 interactions in T cell activation is well documented. However, once CTLs are elicited, TCR-mediated cytotoxicity appears to be uncoupled from the requirement for costimulatory signals. In this study, we show an uncoupling across a broad range of concentrations of pe
Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex.: J Immunol. 1999 Sep 15;163(6):3037-44. Unique Identifier : AIDSLINE MED/99406791; Vila-Coro AJ; Mellado M; Martin de Ana A; Martinez-A C; Rodriguez-Frade JM; Department of Immunology and Oncology, Centro Nacional de; Biotecnologia, Consejo Superior de Investigaciones; Cientificas/Universidad Autonoma de Madrid, Spain.; The trafficking of lymphocyte populations is a complex process controlled by a vast array of molecules. In this process, cells must be able to sense small changes in chemoattractant gradients. Migration through a chemotactic gradient probably employs an on-off mechanism in which chemokine receptor desensitization, int
Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively.: J Immunol. 1999 Sep 15;163(6):3123-30. Unique Identifier : AIDSLINE MED/99406802; Mashikian MV; Ryan TC; Seman A; Brazer W; Center DM; Cruikshank WW; Pulmonary Center, Boston University School of Medicine, MA 02118,; USA.; The ability of HIV-1 gp120 to inhibit chemokine signaling prompted us to determine whether signaling through CD4 by a natural ligand, IL-16, could alter cellular responsiveness to chemokine stimulation. These studies demonstrate that IL-16/CD4 signaling in T lymphocytes results in a selective loss of macrophage-inflam
The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.: J Immunol. 1999 Sep 15;163(6):3131-7. Unique Identifier : AIDSLINE MED/99406803; Dai Z; Arakelov A; Wagener M; Konieczny BT; Lakkis FG; The Carlos and Marguerite Mason Transplantation Research Center,; Renal Division, Department of Medicine, Veterans Affairs Medical; Center, Emory University, Atlanta, GA 30033, USA.; IL-2-dependent, activation-induced T cell death (AICD) plays an important role in peripheral tolerance. Using CD8+ TCR-transgenic lymphocytes (2C), we investigated the mechanisms by which IL-2 prepares CD8+ T cells for AICD. We found that both Fas and TNFR death pathways mediate the AICD of 2C cells. Neutralizing IL-2
Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo.: J Immunol. 1999 Sep 15;163(6):3138-42. Unique Identifier : AIDSLINE MED/99406804; Maldonado MA; MacDonald GC; Kakkanaiah VN; Fecho K; Dransfield M; Sekiguchi D; Cohen PL; Eisenberg RA; Department of Medicine, University of Pennsylvania, Philadelphia; 19104, USA.; We have previously shown that the gld autoimmune syndrome is suppressed in lethally irradiated gld mice reconstituted with a mixture of normal and gld bone marrow (BM). Furthermore, in vivo depletion of normal Thy-1+ cells restores lymphoproliferation and autoantibody production in such chimeras, suggesting that T cel
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.: J Immunol. 1999 Sep 15;163(6):3194-201. Unique Identifier : AIDSLINE MED/99406811; Whitmire JK; Flavell RA; Grewal IS; Larsen CP; Pearson TC; Ahmed R; Emory Vaccine Center, Department of Microbiology and Immunology,; Emory University School of Medicine, Atlanta, GA 30322, USA.; This study documents a striking dichotomy between CD4 and CD8 T cells in terms of their requirements for CD40-CD40 ligand (CD40L) costimulation. CD40L-deficient (-/-) mice made potent virus-specific CD8 T cell responses to dominant as well as subdominant epitopes following infection with lymphocytic choriomeningitis v
Selective retention of activated CD8+ T cells by the normal liver.: J Immunol. 1999 Sep 15;163(6):3202-10. Unique Identifier : AIDSLINE MED/99406812; Mehal WZ; Juedes AE; Crispe IN; Section of Immunobiology, Yale School of Medicine, New Haven, CT; 06520, USA.; Activation-induced cell death resulting in peripheral deletion of CD8+ T cells is associated with the accumulation of large numbers of apoptotic T cells in the liver. The hypothesis that this accumulation results from the intrahepatic trapping of T cells from the circulating pool predicts that the liver should retain
Human fibroblasts transduced with CD80 or CD86 efficiently trans-costimulate CD4+ and CD8+ T lymphocytes in HLA-restricted reactions: implications for immune augmentation cancer therapy and autoimmunity.: J Immunol. 1999 Sep 15;163(6):3239-49. Unique Identifier : AIDSLINE MED/99406817; Smythe JA; Fink PD; Logan GJ; Lees J; Rowe PB; Alexander IE; The Gene Therapy Research Unit, The Children's Medical Research; Institute, The New Children's Hospital, Wentworthville,; Australia. jasons@nch.edu.au; Augmenting immunogenicity by genetically modifying tumor cells to express costimulatory molecules has proven to be a promising therapeutic strategy in murine tumor models and is currently under investigation in human clinical trials for metastatic cancer. However, there are significant technical and logistic problems
Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines.: J Immunol. 1999 Sep 15;163(6):3250-9. Unique Identifier : AIDSLINE MED/99406818; Kohrgruber N; Halanek N; Groger M; Winter D; Rappersberger K; Schmitt-Egenolf M; Stingl G; Maurer D; Division of Immunology, Department of Dermatology, University of; Vienna Medical School, Austria.; Two types of dendritic cells (DC) are circulating in human blood and can be identified by their differential expression of the myeloid Ag CD11c. In this study, we show that CD11c- peripheral blood (PB)-DC correspond to plasmacytoid DC of lymphoid tissue not only by their surface Ag expression profile but, more impress
Selective diapedesis of Th1 cells induced by endothelial cell RANTES.: J Immunol. 1999 Sep 15;163(6):3269-78. Unique Identifier : AIDSLINE MED/99406820; Kawai T; Seki M; Hiromatsu K; Eastcott JW; Watts GF; Sugai M; Smith DJ; Porcelli SA; Taubman MA; Department of Immunology, The Forsyth Institute, Boston, MA; 02115, USA.; Differentiated CD4 T cells can be divided into Th1 and Th2 types based on the cytokines they produce. Differential expression of chemokine receptors on either the Th1-type or the Th2-type cell suggests that Th1-type and Th2-type cells differ not only in cytokine production but also in their migratory capacity. Stimula
Visualization of polyoma virus-specific CD8+ T cells in vivo during infection and tumor rejection.: J Immunol. 1999 Sep 15;163(6):3369-78. Unique Identifier : AIDSLINE MED/99406831; Lukacher AE; Moser JM; Hadley A; Altman JD; Department of Pathology, Emory Vaccine Center, Emory University; School of Medicine, Atlanta, GA 30322, USA. alukach@emory.edu; T cells are critical for clearing infection and preventing tumors induced by polyoma virus, a natural murine papovavirus. We previously identified the immunodominant epitope for polyoma virus-specific CTL in tumor-resistant H-2k mice as the Dk-restricted peptide, MT389-397, derived from the polyoma middle T oncoprotei
Inverted immunodominance and impaired cytolytic function of CD8+ T cells during viral persistence in the central nervous system.: J Immunol. 1999 Sep 15;163(6):3379-87. Unique Identifier : AIDSLINE MED/99406832; Bergmann CC; Altman JD; Hinton D; Stohlman SA; Department of Neurology, University of Southern California School; of Medicine, Los Angeles 90033, USA. cbergman@hsc.usc.edu; Mice infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) clear infectious virus; nevertheless, virus persists in the CNS as noninfectious RNA, resulting in ongoing primary demyelination. Phenotypic and functional analysis of CNS infiltrating cells during acute infection revealed a potent regional
Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection.: J Immunol. 1999 Sep 15;163(6):3403-8. Unique Identifier : AIDSLINE MED/99406835; Flano E; Woodland DL; Blackman MA; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; A CD8+ T cell lymphocytosis in the peripheral blood is associated with the establishment of latency following intranasal infection with murine gammaherpesvirus-68. Remarkably, a large percentage of the activated CD8+ T cells of mice expressing different MHC haplotypes express V beta 4+ TCR. Identification of the ligan
Polarized type 1 cytokine profile in bronchoalveolar lavage T cells of patients with hypersensitivity pneumonitis.: J Immunol. 1999 Sep 15;163(6):3516-23. Unique Identifier : AIDSLINE MED/99406850; Yamasaki H; Ando M; Brazer W; Center DM; Cruikshank WW; First Department of Internal Medicine, Kumamoto University School; of Medicine, Japan.; Hypersensitivity pneumonitis (HP) is characterized by an inflammatory lymphocytic alveolitis comprised of both CD8+ and CD4+ T cells. Animal models suggest that HP is facilitated by overproduction of IFN-gamma, and that IL-10 ameliorates severity of the disease, indicating a Th1-type response. To determine whether a T
Up-regulation of CCR2 chemokine receptor expression and increased susceptibility to the multitropic HIV strain 89.6 in monocytes exposed to glucocorticoid hormones.: J Immunol. 1999 Sep 15;163(6):3524-9. Unique Identifier : AIDSLINE MED/99406851; Penton-Rol G; Cota M; Polentarutti N; Luini W; Bernasconi S; Borsatti A; Sica A; LaRosa GJ; Sozzani S; Poli G; Mantovani A; Department of Immunology and Cell Biology, Istituto di Ricerche; Farmacologiche Mario Negri, Milan, Italy.; Glucocorticoid hormones (GC) are potent antiinflammatory agents widely used in the treatment of diverse human diseases. The present study was aimed at assessing the effect of GC on chemokine receptor expression in human monocytes. Dexamethasone (Dex) up-regulated mRNA expression of the monocyte chemotactic protein (MC
Markers of lymphocyte homing distinguish CD4 T cell subsets that turn over in response to HIV-1 infection in humans.: J Immunol. 1999 Sep 15;163(6):3539-48. Unique Identifier : AIDSLINE MED/99406853; Hengel RL; Jones BM; Kennedy MS; Hubbard MR; McDougal JS; HIV Immunology and Diagnostics Branch, Division of AIDS, National; Center for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; In HIV-1 infection, the abrupt rise in CD4 T cells after effective antiretroviral therapy has been viewed as a measure of HIV-1-related CD4 T cell turnover in the steady state. The early (2-4 wk) response is reportedly dominated by CD4 T cells with a memory (CD45RO) phenotype. It is controversial whether the measureme
Modulation of macrophage and B cell function by glycosaminoglycans.: J Leukoc Biol. 1999 Sep;66(3):391-400. Unique Identifier : AIDSLINE MED/99424627; Wrenshall LE; Stevens RB; Cerra FB; Platt JL; Department of Surgery, University of Minnesota, Minneapolis, USA.; lew@u.washington.edu; There is increasing evidence that the behavior of antigen-presenting cells may be regulated, in part, by the surrounding microenvironment. Components of the microenvironment of solid tissues that might influence antigen-presenting cell functions include glycosaminoglycans. We previously showed that heparan sulfate gly
Regulation of the production of soluble IL-4 receptors in murine cutaneous leishmaniasis. The roles of IL-12 and IL-4.: Unique Identifier : AIDSLINE MED/99424638; Fernandez-Botran R; Chilton PM; Hondowicz BD; Vetvickova J; Yan J; Jones W 3rd; Scott P; Department of Pathology and Laboratory Medicine, University of; Louisville, Kentucky 40292, USA. rafael@louisville.edu; These studies were undertaken with the purpose of elucidating the key signals involved in the regulation of the production of soluble interleukin-4 receptors (sIL-4R) in mice during Th1 and Th2 responses to infection with the parasite Leishmania major. Our results showed that the production of sIL-4R was consistently
Use of recombinant viruses to assess the pattern of early human immunodeficiency virus breakthrough infection in the presence of stavudine.: J Gen Virol. 1999 Sep;80 ( Pt 9):2361-7. Unique Identifier : AIDSLINE MED/99429596; Medina DJ; Tung PP; Strair RK; The Cancer Institute of New Jersey, Robert Wood Johnson School of; Medicine, New Brunswick 08901, USA.; A variety of cell lines were infected with replication-defective recombinant retroviruses in the presence of stavudine ( d4T ). Cells which were infected despite the presence of d4T wer
Sensitivity of human immunodeficiency virus infection to various alpha, beta and gamma chemokines.: J Gen Virol. 1999 Sep;80 ( Pt 9):2369-73. Unique Identifier : AIDSLINE MED/99429597; Greco G; Mackewicz C; Levy JA; Department of Medicine and Cancer Research Institute, University; of California, School of Medicine, San Francisco 94143-1270, USA.; Examination of a large panel of chemokines indicates that in addition to RANTES, MIP-1alpha and MIP-1beta, the beta-chemokine MCP-2 and, to a lesser extent, the gamma-chemokine lymphotactin also show anti-human immunodeficiency virus (HIV) activity in cell culture. The amount of chemokine needed to suppress HIV replic
The appearance of escape variants in vivo does not account for the failure of recombinant envelope vaccines to protect against simian immunodeficiency virus.: J Gen Virol. 1999 Sep;80 ( Pt 9):2375-82. Unique Identifier : AIDSLINE MED/99429598; Almond N; Jenkins A; Jones S; Arnold C; Silvera P; Kent K; Mills KH; Stott EJ; Division of Retrovirology, National Institute of for Biological; Standards and Control, South Mimms, Potters Bar, Herts, UK.; nalmond@nibsc.ac.uk; The presence or evolution of immune escape variants has been proposed to account for the failure of recombinant envelope vaccines to protect macaques against challenge with simian immunodeficiency virus (SIVmac). To address this issue, two groups of three cynomolgus macaques were immunized with recombinant SIV Env vac
DREAM++: flexible docking program for virtual combinatorial libraries.: J Comput Aided Mol Des. 1999 Sep;13(5):513-32. Unique Identifier : AIDSLINE MED/99413030; Makino S; Ewing TJ; Kuntz ID; Department of Pharmaceutical Chemistry, School of Pharmacy,; University of California, San Francisco 94143-0446, USA.; We present a set of programs, DREAM+2 (Docking and Reaction programs using Efficient seArch Methods written in C++), for docking computationally generated ligands into macromolecular binding sites. DREAM++ is composed of three programs: ORIENT++, REACT++ and SEARCH++. The program ORIENT++ positions molecules in a bind
The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro.: J Mol Biol. 1999 Aug 27;291(4):731-44. Unique Identifier : AIDSLINE MED/99384126; Lenzmeier BA; Baird EE; Dervan PB; Nyborg JK; Department of Biochemistry and Molecular Biology, Colorado State; University, Fort Collins, CO, 80523-1870, USA.; The human T-cell leukemia virus type-1 (HTLV-I)-encoded Tax protein enhances viral gene transcription through interaction with three repeated DNA elements located in the viral promoter. These elements, called viral CREs, are composed of an off-consensus eight base-pair cyclic AMP response element (CRE), immediately fl
HIV-1 drug resistance in newly infected individuals [see comments]: JAMA. 1999 Sep 22-29;282(12):1135-41. Unique Identifier : AIDSLINE MED/99429224; Boden D; Hurley A; Zhang L; Cao Y; Guo Y; Jones E; Tsay J; Ip J; Farthing C; Limoli K; Parkin N; Markowitz M; The Aaron Diamond AIDS Research Center, Rockefeller University,; New York, NY 10016, USA.; CONTEXT: There is concern that the widespread use of antiretroviral drugs to treat human immunodeficiency virus 1 (HIV-1) infection may result in the increased transmission of drug-resistant virus. OBJECTIVE: To determine the prevalence of drug resistance-conferring mutations and phenotypic resistance to antiretrovira
Reduced antiretroviral drug susceptibility among patients with primary HIV infection [see comments]: JAMA. 1999 Sep 22-29;282(12):1142-9. Unique Identifier : AIDSLINE MED/99429225; Little SJ; Daar ES; D'Aquila RT; Keiser PH; Connick E; Whitcomb JM; Hellmann NS; Petropoulos CJ; Sutton L; Pitt JA; Rosenberg ES; Koup RA; Walker BD; Richman DD; Department of Medicine, University of California, San Diego, USA.; slittle@ucsd.edu; CONTEXT: The transmission of drug-resistant human immunodeficiency virus (HIV) has been documented, but the prevalence of such transmission is unknown. OBJECTIVE: To assess the spectrum and frequency of antiretroviral susceptibility among subjects with primary HIV infection. DESIGN, SETTING, AND PATIENTS: Retrospectiv
An asymptomatic 41-year-old man with HIV infection, 1 year later.: JAMA. 1999 Sep 22-29;282(12):1176. Unique Identifier : AIDSLINE MED/99429230; Delbanco T; Hartman E
Primary HIV-1 resistance: a new phase in the epidemic? [editorial; comment]: Unique Identifier : AIDSLINE MED/99429231; Pomerantz RJ
[Examination of the posterior eye segment during HIV infection: what is new?]: Klin Monatsbl Augenheilkd. 1999 May;214(5):317-20. Unique Identifier : AIDSLINE MED/99348847; Guex-Crosier Y; Hopital Ophtalmique Jules Gonin, Lausanne.; AIM: A patient was till now considered at high risk of developing a cytomegalovirus retinitis when the CD4+ cells were under 100/mm3. The risk was major when the CD4+ were under 50/mm3. With the onset of a Highly Active Antiretroviral Therapy (HAART) the follow-up of AIDS patients
The status of middle level HIV/STD education as assessed by state and local education agencies.: J Sch Health. 1999 Aug;69(6):239-42. Unique Identifier : AIDSLINE MED/99390384; Wolff WJ; Schoeberlein DR; Essential Strategies, Denver, CO 80248-0022, USA.; estrategies@mindspring.com; During spring 1998 RAD Educational Programs, in cooperation with the National Middle School Association, conducted a needs assessment of middle level HIV/STD prevention programs from the perspective of representatives from state education agencies (SEA) and local education agencies (LEA). Data were collected from 84%
Reliability and validity of French, German, Italian, Dutch, and UK English translations of the Medical Outcomes Study HIV Health Survey.: Med Care. 1999 Sep;37(9):908-25. Unique Identifier : AIDSLINE MED/99421212; Scott-Lennox JA; Wu AW; Boyer JG; Ware JE Jr; Piedmont Research Institute, Inc., Chapel Hill, NC 27514, USA.; OBJECTIVES: Test the reliability and validity of 5 translations of the 34-item version of the MOS HIV for use in multinational clinical trials. RESEARCH DESIGN: Investigators in five countries followed a standardized protocol and recruited HIV+ patients stratified by disease stage: asymptomatic; symptomatic; and AIDS.
[The evolution of AIDS mortality and survival in Barcelona (1981-1997) (see comments)]: Med Clin (Barc). 1999 Jul 10;113(5):169-70. Unique Identifier : AIDSLINE MED/99409508; Garcia de Olalla P; Cayla JA; Brugal MT; Galdos H; Jansa JM; Clos R; Servicio de Epidemiologia, Instituto Municipal de Salud; Publica, Barcelona. polalla@imsb.bcn.es; BACKGROUND: To analyze the evolution of AIDS mortality and survival in Barcelona, Spain . PATIENTS AND METHODS: AIDS-cases registered in Barcelona (Spain) between 1981-1997. Study of mortality and survival probability. RESULTS: Mortality decreased by 55% between 1996-1997. Survival p
[AIDS: more and better life? (editorial; comment)]: Med Clin (Barc). 1999 Jul 10;113(5):171-2. Unique Identifier : AIDSLINE MED/99409509; Castilla J
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial.: Lancet. 1999 Sep 4;354(9181):795-802. Unique Identifier : AIDSLINE MED/99413730; Guay LA; Musoke P; Fleming T; Bagenda D; Allen M; Nakabiito C; Sherman J; Bakaki P; Ducar C; Deseyve M; Emel L; Mirochnick M; Fowler MG; Mofenson L; Miotti P; Dransfield K; Bray D; Mmiro F; Jackson JB; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, MD, USA.; BACKGROUND: The AIDS Clinical Trials Group protocol 076 zidovudine prophylaxis regimen for HIV-1-infected pregnant women and their babies has been associated with a significant decrease in vertical HIV-1 transmission in non-breastfeeding women in developed countries. We compared the safety and efficacy of short-course
Cost effectiveness of single-dose nevirapine regimen for mothers and babies to decrease vertical HIV-1 transmission in sub-Saharan Africa.: Lancet. 1999 Sep 4;354(9181):803-9. Unique Identifier : AIDSLINE MED/99413731; Marseille E; Kahn JG; Mmiro F; Guay L; Musoke P; Fowler MG; Jackson JB; Health Strategies International, Orinda, CA 94563, USA.; emarseille@home.com; BACKGROUND: Identification of economical interventions to decrease HIV-1 transmission to children is an urgent public-health priority in sub-Saharan Africa. We assessed the cost effectiveness of the HIVNET 012 nevirapine regimen. METHODS: We assessed
South Africa to redouble efforts to control the spread of HIV [news]: Lancet. 1999 Sep 4;354(9181):844. Unique Identifier : AIDSLINE MED/99413749; Baleta A
Lipodystrophy in HIV-1-infected patients [letter]: Lancet. 1999 Sep 4;354(9181):867-8. Unique Identifier : AIDSLINE MED/99413765; Mercie P; Tchamgoue S; Dabis F; Pellegrin JL
Lipodystrophy in HIV-1-infected patients [letter]: Lancet. 1999 Sep 4;354(9181):868. Unique Identifier : AIDSLINE MED/99413766; Domingo P; Perez A; Torres OH; Montiel JA; Vazquez G
Spinal tuberculosis in adults. A study of 103 cases in a developed country, 1980-1994.: Medicine (Baltimore). 1999 Sep;78(5):309-20. Unique Identifier : AIDSLINE MED/99428860; Pertuiset E; Beaudreuil J; Liote F; Horusitzky A; Kemiche F; Richette P; Clerc-Wyel D; Cerf-Payrastre I; Dorfmann H; Glowinski J; Crouzet J; Bardin T; Meyer O; Dryll A; Ziza JM; Kahn MF; Kuntz D; Viggo Petersen Center, Lariboisiere Teaching Hospital, Paris.; edouard.pertuiset@wanadoo.fr; Spinal tuberculosis (TB) accounts for about 2% of all cases of TB. New methods of diagnosis such as magnetic resonance imaging (MRI) or percutaneous needle biopsy have emerged. Two distinct patterns of spinal TB can be identified, the classic form, called spondylodiscitis (SPD) in this article, and an increasingly com
Antenatal screening for HIV in Australia: time to revise policies?: Med J Aust. 1999 Aug 16;171(4):201-3. Unique Identifier : AIDSLINE MED/99424024; Ziegler JB; Paediatric HIV Service, Sydney Children's Hospital, NSW.; J.Ziegler@unsw.edu.au
Membrane compatibility and clearance of hepatitis C virus in chronic dialysis patients [letter]: Nephron. 1999;82(4):358. Unique Identifier : AIDSLINE MED/99380457; Adorati M; Pipan C; Botta G
Morphological correlates of neurological dysfunction in macaques infected with neurovirulent simian immunodeficiency virus.: Neuropathol Appl Neurobiol. 1999 Aug;25(4):285-94. Unique Identifier : AIDSLINE MED/99406949; Raghavan R; Cheney PD; Raymond LA; Joag SV; Stephens EB; Adany I; Pinson DM; Li Z; Marcario JK; Jia F; Wang C; Foresman L; Berman NE; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis, Department; of Microbiology, Kansas City, Kansas, USA.; The pattern of neurological disease caused by human immunodeficiency virus (HIV) infection of the central nervous system (CNS) was investigated using a macaque model of acquired immune defiency syndrome (AIDS). Seven of nine macaques inoculated with neurovirulent simian imunodeficiency virus (SIVmac ) developed AIDS w
Reduction in human immunodeficiency virus patient hospitalizations and nontraumatic mortality after adoption of highly active antiretroviral therapy.: Unique Identifier : AIDSLINE MED/99425628; Baum SE; Morris JT; Gibbons RV; Cooper R; Highly active antiretroviral therapy (HAART) has been recommended for human immunodeficiency virus (HIV)-positive patients with a detectable viral load; it typically consists of two reverse
Cervical dysplasia in women with HIV [news]: Nurse Pract. 1999 Aug;24(8):79-80, 82, 84-5. Unique Identifier : AIDSLINE MED/99406226; Goodman L; Croke V; Rodman A; Alexander MK; Prevention of cervical cancer in HIV-positive women is possible through regular cervical cytological screening for early detection and a variety of effective treatment options for dysplasia. Women with HIV infection continue to have an increased rate of CIN, and cervical dysplasia appears to recur more frequently and
Averting needle sticks.: Nursing. 1999 Aug;29(8):28. Unique Identifier : AIDSLINE MED/99434598; Jagger J; Perry J; International Healthcare Worker Safety Center, University of; Virginia, Charlottesville, Va., USA.
[Level of HHV-6A antibodies in symptomless HIV infection as well as in the course of AIDS]: Orv Hetil. 1999 Aug 22;140(34):1881-5. Unique Identifier : AIDSLINE MED/99432588; Ongradi J; Banhegyi D; Marodi CL; Nagy K; Csiszar A; Horvath A; Orszagos Bor- es Nemikortani Intezet, Budapest.; HHV-6A in vitro augments expression of CD4 molecules on the surface of immune cells, facilitates HIV replication and cell death in dual infections. It is hardly known whether these processes take place in vivo; does HHV-6A enhance HIV infection and AIDS progression? To study HHV-6A fresh infections and reactivation, I
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo.: Oncogene. 1999 Aug 12;18(32):4598-605. Unique Identifier : AIDSLINE MED/99398595; Majello B; Napolitano G; Giordano A; Lania L; Department of Genetics, Molecular and General Biology, University; of Naples 'Federico II' and International Institute of Genetics; and Biophysics, CNR, Naples, Italy.; The CDK9 kinase in association with Cyclin T is a component of the transcription positive-acting complex pTEFb which facilitates the transition from abortive to productive transcription elongation by phosphorylating the carboxyl-terminal domain of RNA polymerase II. The Cyclin T1/CDK9 complex is implicated in Tat tran
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.: Oncogene. 1999 Aug 12;18(32):4616-25. Unique Identifier : AIDSLINE MED/99398597; Ariumi Y; Masutani M; Copeland TD; Mimori T; Sugimura T; Shimotohno K; Ueda K; Hatanaka M; Noda M; Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto; 606-8507, Japan.; It has been suggested that DNA-dependent protein kinase (DNA-PK) is a central component of DNA double-strand-break repair. The mechanism of DNA-PK action, however, has not been fully understood. Poly(ADP-ribose) polymerase (PARP) is another nuclear enzyme which has high affinity to DNA ends. In this study, we analysed
Long-term nonprogressors with HIV disease.: Nurs Res. 1999 Sep-Oct;48(5):242-9. Unique Identifier : AIDSLINE MED/99423099; Barroso J; Department of Adult and Geriatric Health, University of North; Carolina at Chapel Hill School of Nursing, 27599, USA.; BACKGROUND: Although biomedical research is being conducted on long-term nonprogressors with HIV disease, there is relatively little research on the psychosocial factors influencing this phenomenon. OBJECTIVE: To describe the perceptions of long-term nonprogressors of their HIV disease and its course. METHOD: A natura
Prophylaxis to combat HIV infection after sexual exposure.: Nurs Times. 1999 Jun 9-15;95(23):44-5. Unique Identifier : AIDSLINE MED/99427216; Hayter M; Department of Community, Primary and Public Health Nursing,; University of Sheffield.; This article explores the use of drugs to treat patients who have recently been exposed to HIV. Known as postsexual exposure prophylaxis, this emerging practice has been accused of creating a number of problems for HIV prevention. However, there is a case that PSEP can make a significant contribution to HIV prevention
A study of cutaneous tuberculosis in children.: Pediatr Dermatol. 1999 Jul-Aug;16(4):264-9. Unique Identifier : AIDSLINE MED/99398617; Ramesh V; Misra RS; Beena KR; Mukherjee A; Department of Dermatology and Venereology and Institute of; Pathology (ICMR), Safdarjang Hospital, New Delhi, India.; Sixty-three children out of a total of 199 patients seen with cutaneous tuberculosis during a 7-year period were included in this study. Culture was positive in only four, and the diagnosis was based on clinical examination, tuberculin reaction, histopathology, and response to antitubercular therapy. Forty had lupus v
[Comparison of infectious complications of long-term and short-term central venous catheterization]: Presse Med. 1999 Sep 4;28(25):1347-51. Unique Identifier : AIDSLINE MED/99436749; Guiguet M; Barbut F; Meynard JL; Raynaud F; Fort MM; Chandon M; Isnard F; Frottier J; Offenstadt G; CLIN, Hopital St Antoine, Paris. guiguet@b3e.jussieu.fr; OBJECTIVES: Risk factors for infectious complications of central venous catheters (CVC) were compared between CVC used for short and long periods to identify patients at risk. PATIENTS AND METHODS: A prospective study was conducted over a 6 month period in two general intensive care units (87 patients with short durat
[Changes in the production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-2 in relation to the immunity in patients with pulmonary tuberculosis]: Probl Tuberk. 1999;(4):31-5. Unique Identifier : AIDSLINE MED/99409202; Knoring VE; Simbirtsev AS; Sakharova IIa; Rekstina TA; Davydova NI; Kotov AIu; Kalinina NM; Pigareva NV; Leonchenko EM; The specific features of production of IL-1 beta, TNF-alpha, IL-2 were studied in 74 patients with various forms of tuberculosis by taking into account the magnitude of an immunological response. Tuberculin, phytohemagglutinin, prodigiosine were used as inducers of the
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32. Unique Identifier : AIDSLINE PDB/1QE1; Sarafianos SG; Das K; Clark AD Jr; Ding J; Boyer PL; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine (CABM) and Rutgers; University Chemistry Department, 679 Hoes Lane, Piscataway, NJ; 08854-5638, USA.; An important component of triple-drug anti-AIDS therapy is 2 , 3 -dideoxy-3 -thiacytidine ( 3TC , lamivudine). Single mutations at residue 184 of the reverse transcriptase (RT) in HIV cause high-level resistance to 3TC and contribute to the failure of a
The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme [see comments]: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10118-22. Unique Identifier : AIDSLINE MED/99398672; Freire E; Department of Biology and Biocalorimetry Center, Johns Hopkins; University, Baltimore, MD 21218, USA. ef@jhu.edu; The interaction of a ligand with a protein occurs at a local site (the binding site) and involves only a few residues; however, the effects of that interaction are often propagated to remote locations. The chain of events initiated by binding provides the basis for fundamental biological phenomena such as allosterism,
Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex.: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10367-72. Unique Identifier : AIDSLINE MED/99398714; Wang CY; Sawyer LS; Murthy KK; Fang X; Walfield AM; Ye J; Wang JJ; Chen PD; Li ML; Salas MT; Shen M; Gauduin MC; Boyle RW; Koup RA; Montefiori DC; Mascola JR; Koff WC; Hanson CV; United Biomedical Inc., 25 Davids Drive, Hauppauge, NY 11788,; USA. pr@unitedbiomedical.com; mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell
Systemic mycobacterioses in AIDS patients as determined by blood cultures on biphasic medium.: Rev Argent Microbiol. 1999 Apr-Jun;31(2):53-7. Unique Identifier : AIDSLINE MED/99354391; Aily DC; Camargo SS; Paro HS; Passos CA; Coelho AG; Sato DN; Shikama ML; Silva RR; Ueki SY; Divisao dos Laboratorios Regionais, Setor de Micobacterias,; Instituto Adolfo Lutz, Sao Paulo, Brasil.; Bacteremia due to mycobacteria can occur in AIDS patients in whom a rapid diagnosis is extremely important in order to plan a therapeutic conduct. Blood culture of mycobacteria using a biphasic system was set up in the Regional Laboratories of the Adolfo Lutz Institute, SP (Campinas, Ribeirao Preto, Santo Andre, Santo
Pneumocystis carinii pneumonia in HIV-infected patients: effect of steroid therapy on surfactant level.: Respir Med. 1999 Jun;93(6):373-8. Unique Identifier : AIDSLINE MED/99394083; Dichter JR; Lundgren JD; Nielsen TL; Jensen BN; Schattenkerk J; Benfield TL; Lawrence M; Shelhamer J; Critical Care Medicine Department, NIH, Bethesda, MD 20892, USA.; Previous studies have suggested alterations in pulmonary surfactant lipid in the setting of Pneumocystis carinii pneumonia in HIV-infected patients. Because pulmonary surfactant lipid is composed of a variety of lipid products and because other phospholipids might be present in bronchoalveolar lavage (BAL) lipid deter
[Contribution of clinical epidemiology to the management of HIV infections]: Rev Med Interne. 1999 Aug;20(8):681-92. Unique Identifier : AIDSLINE MED/99409540; Morlat P; Chene G; Service de medecine interne et maladies infectieuses, hopital; Saint-Andre, Bordeaux, France.; INTRODUCTION: The objective of this publication is to make clinicians more aware of clinical epidemiology through our experience in the field of human immunodefiency virus (HIV) infection. CURRENT KNOWLEDGE AND KEY POINTS: Clinical epidemiology is aimed at studying diagnostic, therapeutic and prognostic aspects of dis
[Pulmonary malacoplakia caused by Rhodococcus equi in AIDS: a case report]: Rev Pneumol Clin. 1999 Jun;55(3):171-4. Unique Identifier : AIDSLINE MED/99416307; Goupil F; Foulet A; Maillard H; Varache N; Varache C; Plat M; Kaswin R; Minaud B; Lebas FX; Service de Pneumologie, C.H. Le Mans.; We describe the observation of a right upper lobe consolidation with cavitation produced by Rhodococcus equi in a patient suffering from AIDS. The inefficacy of a prolonged antimicrobial therapy adapted against R. equi led to a right upper lobectomy. The histopathology showed a pseudotumoral mass, with dense infiltrat
[Multiple and bilateral nodular opacities revealing primary pulmonary lymphoma of the Burkitt-like type in AIDS]: Rev Pneumol Clin. 1999 Jun;55(3):182-6. Unique Identifier : AIDSLINE MED/99416309; Debat Zoguereh D; Ravaux I; Horshowski N; Gallais H; Service de Medecine Interne et des Maladies Infectieuses,; Hopital de la Conception, Marseille, France.; We report the observation of AIDS patient with a history of cough, dyspnea, fever, cachexia and bilateral nodular opacities at the chest X-ray. Infectious etiologies were initially suspected but the recovery was not obtained with their treatment. Only lung biopsy established the precise diagnosis of primary pulmonary
[Excessive watery diarrhea and pronounced fatigue due to Cyclospora cayetanensis infection in an HIV infected traveler returning from the tropics]: Schweiz Med Wochenschr. 1999 Aug 21;129(33):1158-61. Unique Identifier : AIDSLINE MED/99438883; Mosimann M; Nguyen XM; Furrer H; Ambulatorium fur Infektionskrankheiten, Inselspital Bern.; We report the case of a 46-year-old HIV-1 infected patient who acquired a Cyclopsora cayetanensis infection during travel to southeast Asia. He developed excessive watery diarrhoea and pronounced fatigue, which resolved after treatment with cotrimoxazole. The term Cyclospora cayetanensis was first suggested in 1993 fo
[Pastoral care for AIDS patients]: Servir. 1998 Mar-Apr;46(2):92-3. Unique Identifier : AIDSLINE MED/98326166; Ennis G
Hypercalcemia as an early sign of lymphoma in a patient with acquired immunodeficiency syndrome (AIDS).: South Med J. 1999 Sep;92(9):924-6. Unique Identifier : AIDSLINE MED/99426462; Al-Tawfiq JA; Cushing HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis, USA.; Hypercalcemia is uncommon in patients infected with the human immunodeficiency virus (HIV). It has been described in association with cytomegalovirus infection, Pneumocystis carinii pneumonia, granulomatous diseases, and lymphoma. However, symptomatic hypercalcemia as an early sign
Rapid respiratory deterioration and sudden death due to disseminated cryptococcosis in a patient with the acquired immunodeficiency syndrome.: South Med J. 1999 Sep;92(9):927-9. Unique Identifier : AIDSLINE MED/99426463; Penmetsa S; Rose TA; Crook ED; Department of Medicine, University of Mississippi Medical Center,; Jackson 39216, USA.; We report the case of a patient with the acquired immunodeficiency syndrome (AIDS) whose death occurred within 30 hours of hospitalization due to disseminated cryptococcosis, manifested by dizziness, cough, and shortness of breath. The clinical picture was consistent with pneumocystis pneumonia, and antibiotic therapy
[Anti-HB-core antibodies as a surrogate marker in blood donors (letter)]: Sangre (Barc). 1999 Jun;44(3):240-1. Unique Identifier : AIDSLINE MED/99411204; Blejer JL; Saguier MC; Salamone HJ
[Burkitt leukemia as the presenting form of acquired immunodeficiency syndrome. Description of 2 cases (letter)]: Sangre (Barc). 1999 Jun;44(3):242-3. Unique Identifier : AIDSLINE MED/99411207; Gracia A; Gimenez F; Gimenez MJ; Lopez F
Ocular disease in AIDS.: Springer Semin Immunopathol. 1999;21(2):161-77. Unique Identifier : AIDSLINE MED/99386039; Kuo I; Rao NA; Doheny Eye Institute, Department of Ophthalmology, USC School of; Medicine, Los Angeles 90033, USA.
Can blood transfusion transmit disease-producing genes? [editorial]: Transfusion. 1999 Aug;39(8):795-800. Unique Identifier : AIDSLINE MED/99431437; Dzik WH; Okayama A
Comparative evaluation of 14 immunoassays for detection of antibodies to the human T-lymphotropic virus types I and II using panels of sera from Sweden and West Africa.: Transfusion. 1999 Aug;39(8):845-51. Unique Identifier : AIDSLINE MED/99431445; Andersson S; Thorstensson R; Ramirez KG; Krook A; von Sydow M; Dias F; Biberfeld G; Swedish Institute for Infectious Disease Control, Solna.; soren.andersson@orebroll.se; BACKGROUND: A new generation of assays for the detection of human T-lymphotropic virus types I and II (HTLV-I/II) antibodies has been released. These assays incorporate HTLV-I- and HTLV-II-specific antigens, and some are based on new assay principles. Comparative evaluation data that include these new as well as previ
Absence of human T-lymphotropic virus type I tax sequences in a population of normal blood donors in the Baltimore, MD/Washington, DC, area: results from a multicenter study.: Transfusion. 1999 Aug;39(8):904-9. Unique Identifier : AIDSLINE MED/99431454; Cowan EP; Nemo GJ; Williams AE; Alexander RK; Vallejo A; Hewlett IK; Lal RB; Dezzutti CS; Gallahan D; George K; Pancake BA; Zucker-Franklin D; McCurdy PR; Tabor E; Transfusion Medicine Scientific Research Group, National Heart,; Lung, and Blood Institute, Bethesda, Maryland, USA.; cowan@cber.fda.gov; BACKGROUND: It was reported recently that sequences corresponding to the human T-lymphotropic virus type I (HTLV-I) tax gene were detected in peripheral blood mononuclear cells from 8 to 11 percent of healthy blood donors without detectable antibodies to HTLV-I. A multicenter blind study was conducted to determine if
Autologous blood use in percutaneous nephrolithotomy.: Urology. 1999 Sep;54(3):444-9. Unique Identifier : AIDSLINE MED/99402336; Stoller ML; Lee KL; Schwartz BF; Viele MK; Department of Urology, University of California, San Francisco; 94143-0738, USA.; OBJECTIVES: Preoperative autologous blood (AUB) donation has decreased patient exposure to allogenic blood (ALB) products and associated infectious risk. The risk of contracting hepatitis C and human immunodeficiency virus is 1 in 103,000 and 1 in 678,000, respectively, after receiving 1 U ALB. Elective surgical proce
[Basic results of studying the problem of "AIDS" since 1997]: Vopr Virusol. 1998 Nov-Dec;43(6):244-7. Unique Identifier : AIDSLINE MED/99418149; Pokrovskii VI; Kraevskii AA; Pokrovskii VV; Uryvaev LV; Matsevich GR; Iurin OG; Galegov GA; Reshetnikova LN
[Genetic characteristics of variants of human immunodeficiency virus type 1, causing an epidemic among substance abusers in Commonwealth of Independent States countries]: Vopr Virusol. 1998 Nov-Dec;43(6):253-6. Unique Identifier : AIDSLINE MED/99418151; Bobkov AF; Pokrovskii VV; Selimova LM; Ladnaia NN; Kazennova EV; Bobkova MR; Khanina TA; Kravchenko AV; Iurin OG; Saukhat SR; Gag/env nucleotide sequences of human immunodeficiency virus type 1 (HIV-1) variants detected in drug users in Russia , Ukraine , and Belarus are analyzed. Two HIV-1 subtypes A and B circulate in this risk gr
[Biological properties of primary HIV-1 isolates with varying serotype]: Vopr Virusol. 1998 Nov-Dec;43(6):256-61. Unique Identifier : AIDSLINE MED/99418152; Pashkova TA; Iaroslavtseva NG; Shchelkanov MIu; Papuashvili MN; Sakhuriia IB; Kornilaeva GV; Karamov EV; Russian HIV variants with common (rapid/high SI and slow/low NSI) and rare (slow/low SI and rapid/high NSI) phenotypes are described. SI variants demonstrate a higher p24 concentration level than serotype-independent NSI. The majority of SI variants belonging to A, B, and C serotypes were isolated from patients with m
[Achievements in drug therapy of HIV infection and AIDS, presented at the 12th International Conference on AIDS]: Vopr Virusol. 1998 Nov-Dec;43(6):285-6. Unique Identifier : AIDSLINE MED/99418158; Galegov GA
Drug use and syphilis. Co-factors for HIV transmission among commercial sex workers in Guyana.: West Indian Med J. 1999 Jun;48(2):52-6. Unique Identifier : AIDSLINE MED/99422270; Persaud NE; Klaskala W; Tewari T; Shultz J; Baum M; Ministry of Health, Guyana.; A cross-sectional survey was conducted among 124 street- and brothel-based female commercial sex workers (CSWs) in Georgetown in January and February 1997 to determine the seroprevalence of human immunodeficiency virus (HIV) infection and describe the sexual practices and drug use patterns. Their median age was 30 yea
Drug use, sexual behaviour and HIV risk of the homeless in Port-of-Spain, Trinidad.: West Indian Med J. 1999 Jun;48(2):57-60. Unique Identifier : AIDSLINE MED/99422271; Reid SD; Department of Psychiatry, University of the West Indies, Faculty; of Medical Sciences, Mount Hope, Trinidad and Tobago.; Data were collected from 88 homeless persons in Port-of- Spain , Trinidad to assess HIV risk. 68% of the sample were engaging in unprotected sex with multiple partners, 25% were exchanging sex for m
Host-pathogen relationship: evasion from control [editorial]: Wien Klin Wochenschr. 1999 Jun 4;111(11):417-8. Unique Identifier : AIDSLINE MED/99348976; Dierich MP
Dynamics of immune escape in HIV infection.: Unique Identifier : AIDSLINE MED/99348977; Wodarz D; Nowak MA; The dynamics between pathogens and the immune system involve complicated interactions of many different components and this makes the use of mathematical models necessary to provide a correct interpretation of empirical results as well as to generate new insights and hypotheses. We demonstrate this approach by discuss
The V3 loop based multi-epitope polypeptide TAB9 adjuvated with montanide ISA720 is highly immunogenic in nonhuman primates and induces neutralizing antibodies against five HIV-1 isolates.: Vaccine. 1999 May 4;17(18):2311-9. Unique Identifier : AIDSLINE MED/99330394; Gomez CE; Navea L; Lobaina L; Dubed M; Exposito N; Soto A; Duarte CA; Departamento de SIDA, Centro de Ingenieria Genetica y; Biotecnologia, Ciudad Habana, Cuba. carlos.duarte@cigb.edu.cu; In a previous work we selected montanide ISA720 (M-ISA720) among different adjuvants for the vaccination with a V3 loop based multi-epitope polypeptide TAB9. In this paper we present the evaluation of the toxicity and immunogenicity of this formulation in non-human primates. TAB9 in M-ISA720 was highly immunogenic in
Interleukin (IL)-4, IL-10 and IL-12 profile in serum of patients with alveolar echinococcosis.: Acta Trop. 1999 Jul 30;73(2):165-74. Unique Identifier : AIDSLINE MED/99392725; Wellinghausen N; Gebert P; Kern P; Section of Infectious Diseases and Clinical Immunology,; University of Ulm, Germany.; Alveolar echinococcosis (AE), caused by Echinococcus multilocularis (E.m.), provokes a characteristic immune response. Based mainly on in vitro studies, Th2 dominated immunity is associated with increased susceptibility to disease, while Th1 cell activation is assumed to induce protective immunity. We investigated ser
HIV screening [news]: Am Fam Physician. 1999 Sep 1;60(3):1023. Unique Identifier : AIDSLINE MED/99426413; Rose VL
FDA warning on HIV tests purchased on the Internet [news]: Am Fam Physician. 1999 Sep 1;60(3):1026, 1029. Unique Identifier : AIDSLINE MED/99426414; Rose VL
Evaluation and treatment of weight loss in adults with HIV disease.: Am Fam Physician. 1999 Sep 1;60(3):843-54, 857-60. Unique Identifier : AIDSLINE MED/99426399; Williams B; Waters D; Parker K; Department of Medicine, University of New Mexico School of; Medicine, Albuquerque 87131, USA.; Weight loss late in the course of human immunodeficiency virus (HIV) disease is common and often multifactorial. Increased energy expenditure in response to opportunistic disease, as well as to HIV infection itself, can lead to protein-calorie malnutrition similar to that observed in starvation. Weight loss of as litt
HIV testing in substance abusers.: Am J Drug Alcohol Abuse. 1999 May;25(2):269-80. Unique Identifier : AIDSLINE MED/99321083; Samet JH; Mulvey KP; Zaremba N; Plough A; Department of Medicine, Boston Medical Center, Boston University; School of Medicine, Massachusetts, USA. jsamet@bu.edu; HIV testing among substance abusers in the United States is a significant public and individual health issue in need of further examination. We analyzed interview data gathered over 15 months in 1992 and 1993 from 2315 patients on presentation for addiction treatment to determine the f
Longitudinal changes in sexual risk behavior among HIV+ and HIV- male injecting drug users.: Am J Drug Alcohol Abuse. 1999 May;25(2):281-303. Unique Identifier : AIDSLINE MED/99321084; Dolezal C; Meyer-Bahlburg HF; Liu X; Ehrhardt AA; Exner TM; Rabkin JG; Gorman JM; Marder K; Stern Y; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute and Columbia University, New York 10032,; USA.; Injecting drug users (IDUs) play a prominent role in the transmission of human immunodeficiency virus (HIV), particularly in urban areas such as New York City, where they comprise nearly half of all adult acquired immunodeficiency syndrome (AIDS) cases. Intervention studies have demonstrated that IDUs are responsive t
Trichomoniasis in pregnant human immunodeficiency virus-infected and human immunodeficiency virus-uninfected congolese women: prevalence, risk factors, and association with low birth weight.: Am J Obstet Gynecol. 1999 Sep;181(3):656-62. Unique Identifier : AIDSLINE MED/99417455; Sutton MY; Sternberg M; Nsuami M; Behets F; Nelson AM; St Louis ME; Division of STD Prevention, National Center for HIV, Centers for; Disease Control, Atlanta, GA 30333, USA.; OBJECTIVE: We sought to assess the prevalence of and risk factors for vaginal trichomoniasis in human immunodeficiency virus-infected and human immunodeficiency virus-uninfected pregnant Congolese women and its relationship to pregnancy outcomes. STUDY DESIGN: We performed a nested case-control study of 215 infected a
The use of human immunodeficiency virus postexposure prophylaxis after successful artificial insemination.: Am J Obstet Gynecol. 1999 Sep;181(3):760-1. Unique Identifier : AIDSLINE MED/99417475; Bloch M; Carr A; Vasak E; Cunningham P; Smith D; A case is reported of a woman who was exposed to human immunodeficiency virus through self-insemination. She was artificially inseminated with fresh semen obtained from a gay man in whom HIV seroconversion was taking place. Postexposure prophylaxis with antiretrovirals was initiated 10 days later, and despite successf
Activation of infiltrating cytotoxic T lymphocytes and lymphoma cell apoptotic rates in gastric MALT lymphomas. Differences between high-grade and low-grade cases.: Am J Pathol. 1999 Sep;155(3):823-9. Unique Identifier : AIDSLINE MED/99419279; Guidoboni M; Doglioni C; Laurino L; Boiocchi M; Dolcetti R; Division of Experimental Oncology 1,(*) Centro di Riferimento; Oncologico, Aviano, Italy Belluno City Hospital, Belluno, Italy.; In this study, we have characterized infiltrating T lymphocytes from 13 low-grade and 17 high-grade primary gastric MALT lymphomas by immunohistochemistry, with particular regard to the presence, activation, and topographic distribution of cytotoxic effectors. Although the prevalence of CD4+ and CD8+ cells was similar
Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations.: Am J Pathol. 1999 Sep;155(3):941-7. Unique Identifier : AIDSLINE MED/99419291; Chu PG; Chang KL; Chen WG; Chen YY; Shibata D; Hayashi K; Bacchi C; Bacchi M; Weiss LM; Division of Pathology, City of Hope National Medical Center,; Duarte, California 91010-0269, USA.; Different ethnic groups with a high human leukocyte antigen (HLA)-A11 prevalence have been shown to experience a high rate of Epstein-Barr virus (EBV) infection, EBV-associated malignancies, and Epstein-Barr nuclear antigen (EBNA)-4 mutations. The epitopes 399-408 and 416-424 of EBNA-4 are major antigenic epitopes tha
Clinical and biological characteristics of human immunodeficiency virus-infected and uninfected intravascular drug users in Ho Chi Minh City, Vietnam.: Am J Trop Med Hyg. 1999 Sep;61(3):420-4. Unique Identifier : AIDSLINE MED/99426271; Follezou JY; Lan NY; Lien TX; Lafon ME; Tram LT; Hung PV; Aknine X; Lowenstein W; Ngai NV; Theodorou I; Delfraissy JF; Debre P; Fleury HJ; Barre-Sinoussi F; Chi NH; Centre Hospitalo-Universitaire Pitie-Salpetriere, Paris,; France.; To define the medical characteristics of intravascular drug users in Ho Chi Minh City, Vietnam , we examined 280 men, of whom 235 were infected with human immunodeficiency virus (HIV), being treated in a rehabilitation center. The patients used mainly opium, often in shooting galle
ISA assay for retroviruses [news]: Anal Chem. 1999 Aug 1;71(15):512A. Unique Identifier : AIDSLINE MED/99378505
Human T-cell lymphotrophic virus type-I tax gene induces secretion of human macrophage inflammatory protein-1alpha.: Unique Identifier : AIDSLINE MED/99393322; Sharma V; May CC; Department of Biology, University of West Florida, Pensacola,; Florida, 32514, USA. vsharma@uwf.edu; Human T-cell lymphotropic virus I (HTLV-I) encodes for a 40-kDa protein, Tax, which is important for the immortalization of T cells. Tax has been shown to transactivate several cellular genes. In this study, we show that MIP-1alpha is selectively expressed and secreted in the tax transfected Jurkat cell line upon mito
Proteolytic fragments of anti-HIV and anti-tumor proteins MAP30 and GAP31 are biologically active.: Biochem Biophys Res Commun. 1999 Sep 7;262(3):615-23. Unique Identifier : AIDSLINE MED/99400421; Huang PL; Sun Y; Chen HC; Kung HF; Lee-Huang S; American Biosciences, New York, New York, 10021, USA.; We analyzed the structural and functional organization of anti-HIV and anti-tumor proteins MAP30 and GAP31 by limited proteolysis with endopeptidases Lys-C and Glu-C (V8). MAP30 and GAP31 are resistant to proteolytic digestion under conditions of as much as 5% (w/w) proteases. In the presence of 10% (w/w) protease, th
Collateral resistance of a dideoxycytidine-resistant cell line to 5-fluoro-2'-deoxyuridine.: Biochem Biophys Res Commun. 1999 Sep 7;262(3):657-60. Unique Identifier : AIDSLINE MED/99400429; Agarwal RP; Han T; Fernandez M; Department of Medicine (M-862), University of Miami School of; Medicine, Miami, Florida, 33101, USA.; ragarwal@mednet.med.miami.edu; Exposure of a human lymphocytic cell line, H9 cells, to 0.5 microM and 5.0 microM dideoxycytidine ( ddC ) resulted in isolation of ddC-resistant H9-ddC0.5w and H9-ddC5.0w cell lines. In addition, these cell lines were also resistant to azidothymidine an
$156 million budget increase to fight HIV/AIDS in African American & other minority communities.: World. 1998 Dec;(No 92):1. Unique Identifier : AIDSLINE AIDS/99704455; A series of initiatives was established to invest $156 million in efforts to fight HIV/AIDS in minority populations, where AIDS is still a leading cause of death among men and women between 25 and 44 years of age. The initiatives will target specific communities and includes technical assistance and increased access t
Study of drug resistance in "naive" patients.: World. 1998 Dec;(No 92):7. Unique Identifier : AIDSLINE AIDS/99704456; A study called AVG-US-03 is measuring the extent of drug-resistant HIV virus in treatment-naive patients, using genotypic and phenotypic testing. Location sites for this trial are listed. Contact information is provided.
IL-2 plus HAART reduces HIV in immune system "hiding places".: World. 1998 Dec;(No 92):7. Unique Identifier : AIDSLINE AIDS/99704457; A study performed at the National Institute of Allergy and Infectious Diseases (NIAID) showed that a treatment combining highly active antiretroviral therapy (HAART) with Interleukin-2 ( IL-2 ) was successful in reducing the amount of HIV in resting CD4+ T-cells in patie
Reaching out: the BP helpline.: Body Posit. 1998 Nov;XI(11):12-6. Unique Identifier : AIDSLINE AIDS/99704458; Vazquez-Pacheco R; The Body Positive Helpline is one of the oldest AIDS hotlines in New York. It was founded in the late 1980s by a grant given to Body Positive. The types of calls received by the helpline have greatly changed since the earlier days when resources were scarce. Calls used to have a sense of urgency and desperation, and o
Lifeline: Samaritans of New York.: Body Posit. 1998 Nov;XI(11):18-21. Unique Identifier : AIDSLINE AIDS/99704459; Foley D; The Samaritans of New York is a suicide prevention hotline operated by a group of 90 trained volunteers. The hotline handles approximately 40,000 calls per year ranging from people who are facing serious illnesses to people who are deeply depressed about personal situations. Every call is strictly confidential, and al
Balancing act: the ultimate balance nutrition consulting center.: Body Posit. 1998 Nov;XI(11):28-31. Unique Identifier : AIDSLINE AIDS/99704460; Engle L; Nutritional issues often complicate health care but are very important in HIV treatment where diet can play a strong role in drug absorption and effectiveness. A Canadian company has started a for-fee nutritional counseling service called Ultimate Balance. The nutritionists at Ultimate Balance require medical disclosu
Dangerous liaisons: rape and HIV.: Body Posit. 1998 Nov;XI(11):32-7. Unique Identifier : AIDSLINE AIDS/99704461; Hoskins VM; Rape crisis intervention teams provide support and counseling to people who have been victimized by rape or sexual assault. The group from the Mount Sinai Rape Crisis Intervention Program describes how counselors act as advocates for the victim by answering questions and providing emotional support. The group is troub
A sampler of hotlines and helplines.: Body Posit. 1998 Nov;XI(11):38-9. Unique Identifier : AIDSLINE AIDS/99704462; A wide variety of hotlines and helplines exist in New York City and nationally. Sixteen hotlines and helplines are described. Information is provided on the types of clients each hotline or helpline target. Hours of operation and contact information are included.
Maintaining HIV therapies: adherence conference excerpts--part 2 of 3.: Body Posit. 1998 Nov;XI(11):40-2 contd. Unique Identifier : AIDSLINE AIDS/99704463; Marer M; St Luke's / Roosevelt HIV Center, New York, NY.; A seminar hosted by Body Positive and the Clinical Education Initiative at Mount Sinai Medical Center discussed the problems with adhering to HIV therapies. Such problems include difficulties in tolerating treatments and unpleasant side effects. Two case studies are presented. One describes the problems in adhering to
FDA approves efavirenz. Food and Drug Administration.: BETA. 1998 Oct;:3. Unique Identifier : AIDSLINE AIDS/99704464; Highleyman L; The Food and Drug Administration ( FDA ) approved DuPont Pharma s new non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz ( Sustiva , DMP-266).
Advocates call for fair drug pricing.: BETA. 1998 Oct;:3. Unique Identifier : AIDSLINE AIDS/99704465; Highleyman L; The Fair Price Working Group has called on Glaxo Wellcome and DuPont Pharma to reduce the prices of their new drugs to prices which are similar to other drugs in the same class. The group noted that AIDS Drug Assistance Programs (ADAPs) and Medicaid are already financially
Expanded access program begins.: BETA. 1998 Oct;:3. Unique Identifier : AIDSLINE AIDS/99704466; Highleyman L; Vertex Pharmaceuticals has begun enrollment for an expanded access program for amprenavir ( Agenerase , 141W94). There are three treatment options for this program, including one that evaluates amprenavir in combination with other
Twice-daily Indinavir dosing not recommended.: BETA. 1998 Oct;:4. Unique Identifier : AIDSLINE AIDS/99704467; Highleyman L; Merck and Company has announced that it is discontinuing trials for the twice-daily dosage of Indinavir ( Crixivan ). Study results indicate that the experimental regimen was not as eff
Ritonavir manufacturing problems.: BETA. 1998 Oct;:4. Unique Identifier : AIDSLINE AIDS/99704468; Highleyman L; Abbott Laboratories has not yet been able to resolve manufacturing difficulties with its protease inhibitor Ritonavir ( Norvir ); the problem invol
Protease inhibitors may be associated with premature births.: BETA. 1998 Oct;:4. Unique Identifier : AIDSLINE AIDS/99704469; Highleyman L; The National Institutes of Health (NIH) announced that it has temporarily suspended enrollment of pregnant women into perinatal trials of protease inhibitors because protease inhibitors may increase the risk of premature births. Enrollment was halted for Pediatric A
FDA approves fomivirsen, famciclovir, and Thalidomide. Food and Drug Administration.: BETA. 1998 Oct;:5. Unique Identifier : AIDSLINE AIDS/99704470; Highleyman L; The FDA has recently approved three new drugs. Fomivirsen (Vitravene), developed by Isis Pharmaceuticals , was approved as a treatment for cytomegalovirus ( CMV
California increases ADAP funding; SFAF now an ADAP site.: BETA. 1998 Oct;:6. Unique Identifier : AIDSLINE AIDS/99704471; Highleyman L; The California budget approved by Governor Pete Wilson included a $30 million increase for the AIDS Drug Assistance Program (ADAP) funding, which pays for HIV/AIDS drugs for uninsured and underinsured patients. The increase brings the total ADAP funding to $122 million, allowing California to nearly double the number
Hydroxyurea.: BETA. 1998 Oct;:7. Unique Identifier : AIDSLINE AIDS/99704472; Gortner C; Hydroxyurea, developed as a treatment for cancer and sickle-cell anemia, continues to demonstrate promise as a component of anti-HIV regimens. Its most common side effect is bone marrow suppression, which can lead to low blood cell counts. For people intolerant or resistant to various anti-HIV drugs, a possible treatm
FddA: antiretroviral in development.: BETA. 1998 Oct;:7-8. Unique Identifier : AIDSLINE AIDS/99704473; Hanna L; The experimental reverse transcriptase inhibitor FddA (lodenosine) has shown promise in early studies. The drug was originally developed by the National Cancer Institute (NCI) and appears to have little in vitro cross-resistance with other drugs in its class, including
ABT-378: a second generation protease inhibitor.: BETA. 1998 Oct;:8, 55. Unique Identifier : AIDSLINE AIDS/99704474; Highleyman L; ABT-378 is a second generation protease inhibitor currently undergoing clinical trials. It was developed by Abbott Laboratories and does not yet have a brand or generic name. ABT-378 was engineered to overcome some of the problems associated with the
A new approach to initial antiretroviral therapy: protease-sparing combination regimens.: BETA. 1998 Oct;:9-13. Unique Identifier : AIDSLINE AIDS/99704475; Hanna L; Some physicians are beginning to prescribe potent drug cocktails that do not include protease inhibitors . This is a departure from the standard treatment that has included protease inhibitors since their introduction in recent years. Protease inhibitors remain among
Highlights on women and pregnancy from the 12th World AIDS Conference.: BETA. 1998 Oct;:14-7. Unique Identifier : AIDSLINE AIDS/99704476; Mirken B; Women s issues were prominently featured at the 12th World AIDS Conference, and considerable attention was given to treatments that aim to prevent vertical HIV transmission. The results of a short-course AZT intervention and its effect on vertical tra
Tuberculosis.: BETA. 1998 Oct;:18-25. Unique Identifier : AIDSLINE AIDS/99704477; Highleyman L; Approximately one-third of the world s population is infected with tuberculosis (TB), and TB kills more people worldwide than any other infectious disease. TB infection, however, is not the same as active TB disease. Nine out of ten people with healthy immune systems who are infected with TB do not develop active TB d
Vaccine news from the 12th World AIDS Conference.: BETA. 1998 Oct;:26-9. Unique Identifier : AIDSLINE AIDS/99704478; Mirken B; Researchers at the 12th World AIDS Conference were more optimistic than they had been about vaccine studies. The development of a preventive vaccine is being seen as a critical issue, with the majority of new HIV infections occurring in the nations where people cannot afford highly active antiretroviral therapy (HAART
Post-exposure prophylaxis: still more questions than answers.: BETA. 1998 Oct;:29-32. Unique Identifier : AIDSLINE AIDS/99704479; Mirken B; For the first time, the World AIDS Conference included a session devoted to the issue of post-exposure prophylaxis (PEP). PEP has been used regularly for healthcare workers since 1996, when the Centers for Disease Control and Prevention (CDC) published data showing a 79 percent lower rate of seroconversion among worke
Open clinical trials for HIV/AIDS treatments.: BETA. 1998 Oct;:56-8. Unique Identifier : AIDSLINE AIDS/99704480; Stephenson K; Clinical trials for HIV/AIDS treatments are described. The information provided includes the purpose of the study, the requirements to qualify as a participant, and the length of the study. Information was drawn from an on-line database called Trials Search, the most comprehensive source for clinical trials informatio
Appeals court set to re-examine dental bias case.: AIDS Policy Law. 1998 Oct 30;13(20):1, 10, 12. Unique Identifier : AIDSLINE AIDS/99704481; The First U.S. Circuit Court of Appeals will be re-reviewing the case of Randon Bragdon, a dentist accused of violating the rights of Sidney Abbott, because he preferred to treat her in a hospital, rather than in his dental office. The results of the case could have important ramifications for both health care provide
Panel urges universal testing of pregnant women for HIV.: AIDS Policy Law. 1998 Oct 30;13(20):1, 8-9. Unique Identifier : AIDSLINE AIDS/99704482; A panel at the Institute of Medicine has produced a report urging that HIV tests be given to every pregnant woman and that testing become a regular part of prenatal care. A patient would be notified of the mandatory HIV test, but written consent would not be required. The panel also urged that standard pre-test counse
Judge lets plaintiff use pseudonym in 'regarded as' case.: AIDS Policy Law. 1998 Oct 30;13(20):2. Unique Identifier : AIDSLINE AIDS/99704483; U.S. District Judge Laonie M. Brinkema is permitting an HIV-negative patient to use a pseudonym in her lawsuit against a Virginia obstetrician-gynecologist. The judge warned Dr. Michael W. Corbin and his lawyer that they would be facing sanctions if they continued using the patient s real name in court filings, which
Funding bill contains extra spending on HIV care programs.: AIDS Policy Law. 1998 Oct 30;13(20):3. Unique Identifier : AIDSLINE AIDS/99704484; Congress is working on an omnibus appropriations bill which will fund key government programs, including AIDS-related programs. The 3000 page bill increases funding for the Ryan White CARE Act, partially due to a need by AIDS Drug Assistance Programs (ADAPs). In addition, AIDS Action and the Congressional Black Caucus
Debate continues over how States should track HIV cases.: AIDS Policy Law. 1998 Oct 30;13(20):4-5. Unique Identifier : AIDSLINE AIDS/99704485; The Washington State Board of Health is moving toward an HIV surveillance program that tracks HIV by using the names of those who test positive. Anonymous testing would still be allowed, but once a person sought treatment, their name would be entered into a state registry. Advocacy groups consider the move a setback s
High court considers whether ADA claims must be arbitrated.: AIDS Policy Law. 1998 Oct 30;13(20):6. Unique Identifier : AIDSLINE AIDS/99704486; The U.S. Supreme Court has been asked to decide whether labor agreements which require arbitration to resolve disputes, deprive individual members of their right to sue their employers under the Americans with Disabilities Act. The case involves an unemployed longshoreman named Ceasar Wright who was injured in 1992 an
Supreme Court to tackle ADA/social security conflict.: AIDS Policy Law. 1998 Oct 30;13(20):7. Unique Identifier : AIDSLINE AIDS/99704487; The Supreme Court is scheduled to hear arguments involving Leonard C. McNemar who claims that he lost his job because he has AIDS. Originally, the Third U.S. Circuit Court of Appeals ruled that he was barred from suing because he had accepted disability payments while waiting for the Equal Employment Opportunity Commi
Bragdon gains allies in his argument on 'direct threat'.: AIDS Policy Law. 1998 Oct 30;13(20):11. Unique Identifier : AIDSLINE AIDS/99704488; Dentist Randon Bragdon has gained some support from the medical community in his claim that HIV poses a direct threat to health care workers. Bragdon was at a disadvantage earlier in the case when the patient s position had more support than Bragdon s position. However, support appears to have shifted so that both par
Illinois adopts 'actual exposure' rule for distress claims.: AIDS Policy Law. 1998 Oct 30;13(20):13. Unique Identifier : AIDSLINE AIDS/99704489; The Illinois Supreme Court has ruled that plaintiffs must prove actual exposure to HIV if they hope to recover damages in fear-of-AIDS lawsuits. Most state courts accept that as the standard for determining if a claim is legitimate. Two cases were addressed in the ruling. In one case, Eileen Majca sued Dr. Steven Beek
Supreme Court declines appeal of surgical technician.: AIDS Policy Law. 1998 Oct 30;13(20):14. Unique Identifier : AIDSLINE AIDS/99704490; The U.S. Supreme Court declined to hear a case of a man who lost his job as a surgical technician because he has HIV. William Mauro sued the Borgess Medical Center for removing him from his job, charging violations of the American with Disabilities Act and the Federal Rehabilitation Act. The hospital contended that Ma
Hawaii enacts new law to test sexual assailants.: AIDS Policy Law. 1998 Oct 30;13(20):14. Unique Identifier : AIDSLINE AIDS/99704491; Hawaii has enacted a new law to enable victims of sexual assaults to obtain court orders that mandate HIV testing of the attackers. Senate Bill 1273 requires that victims are offered counseling and the right to have the attacker tested if found guilty of specific sexual offenses. This bill applies to juveniles and adu
Experts failed to justify testing of man who bit officer.: AIDS Policy Law. 1998 Oct 30;13(20):15. Unique Identifier : AIDSLINE AIDS/99704492; A man charged with biting a police officer will not have to undergo HIV testing, because the prosecutor failed to prove the likelihood that the man s saliva touched the officer. James J. Johnson bit the officer on the leg, and although the skin was broken, the officer was wearing duty pants and long underwear, and the
Partner notification.: AIDS Policy Law. 1998 Oct 30;13(20):16. Unique Identifier : AIDSLINE AIDS/99704493; The Association of State and Territorial Health Officials (ASTHO) supports partner notification, but is troubled by the methods advocated by the HIV Partner Protection Act (H.R. 4431). H.R. 4431 is a one-size-fits-all solution that requires all states to adopt programs to notify the sex or needle-sharing partners of
Fight over needles.: AIDS Policy Law. 1998 Oct 30;13(20):16. Unique Identifier : AIDSLINE AIDS/99704494; The governor of New Jersey and her AIDS advisory committee are in disagreement over the best way to prevent HIV infection among injection drug users. Gov. Christie Whitman is opposed to needle exchange programs, but an ad hoc advisory committee is pushing for both needle exchanges and the legalization of over-the-coun
Stigma law.: AIDS Policy Law. 1998 Oct 30;13(20):16. Unique Identifier : AIDSLINE AIDS/99704495; Massachusetts enacted a law, called House No. 2099, that relieves real estate brokers from liability for not disclosing the history of a property to a potential buyer. The statute says that certain information does not need to be disclosed in a real estate transaction. Such information includes whether any previous oc
T-20--a fusion drug, first of several to come.: Treat Update. 1998 Dec;10(10):2. Unique Identifier : AIDSLINE AIDS/99704496; Researchers at Trimeris Inc. have developed and tested a small molecule, called T-20, which prevents HIV from attaching to cells. Preliminary results show a dramatic decline in HIV levels, and the drug appears to have low toxicity. T-20 is given via infusion, although other companies are developing similar compounds t
Viral load--how low is best?: Treat Update. 1998 Dec;10(10):2-3. Unique Identifier : AIDSLINE AIDS/99704497; Antiviral therapy aims to suppress HIV to undetectable levels, and technology to measure these levels is constantly improved. Chiron 3 and similar tests can now detect viral loads as low as 50 copies. Viral load tests have also been valuable in assessing the effectiveness of antiviral drugs. An alliance of mathematici
Maintaining a low viral load with Nevirapine?: Treat Update. 1998 Dec;10(10):3-4. Unique Identifier : AIDSLINE AIDS/99704498; A study called INCAS enrolled 150 treatment-naive subjects. Half of the subjects had CD4+ counts of 370 and a viral load of about 32,000 copies. Subjects were divided into groups that received AZT and Nevirapine, ddI and Nevirapine, or AZT with ddI an
Macrophages--promise and peril.: Treat Update. 1998 Dec;10(10):4-5. Unique Identifier : AIDSLINE AIDS/99704499; Anti-HIV agents can suppress virus levels in blood and lymph nodes by inhibiting HIV from making infected T-cells into virus producers. However, anti-HIV agents are not as effective in suppressing viral replication in cells that are known as macrophages (macs). HIV-infected macs do not die as quickly as infected T-cel
Evolving strategies to attack hepatitis C.: GMHC Treat Issues. 1998 Dec;12(12):1-5. Unique Identifier : AIDSLINE AIDS/99704500; Norton M; Hepatitis C (HCV) was known as either non-A, non-B, or transfusion-associated hepatitis prior to 1989. Today, 4 million Americans are infected with the virus, and up to 10,000 Americans die each year from HCV complications. HCV is now the leading cause of liver cancer and the most common reason for liver transplants.
Soaring prices, soaring sales.: GMHC Treat Issues. 1998 Dec;12(12):5-7. Unique Identifier : AIDSLINE AIDS/99704501; Grinberg L; DuPont Pharmaceuticals and Glaxo Wellcome began marketing two new drugs, and the pricing of the drugs started a controversy. DuPont s efavirenz (
Wrapping up the 105th Congress.: GMHC Treat Issues. 1998 Dec;12(12):7-8. Unique Identifier : AIDSLINE AIDS/99704502; Link D; The 105th Congress was one of the most fiercely partisan in memory. It approved historic increases in AIDS funding, wrestled through the Clinton impeachment process, and saw dramatic changes in leadership. Virtually all legislative activity related to HIV funding occurred just before the election, in an omnibus budget
Are echinacea and HIV not a good mix?: Treat Update. 1999 Feb;11(1):3. Unique Identifier : AIDSLINE AIDS/99704503; Echinacea is an extract from a North American plant and is often used to treat infections, especially the common cold. Because it is able to stimulate the immune system, some people with HIV/AIDS have considered using it as a part of their treatment regimen. However, study results indicate that echinacea weakens the i
Study finds NAC fails to prevent Bactrim/Septra hypersensitivity.: Treat Update. 1999 Feb;11(1):4-5. Unique Identifier : AIDSLINE AIDS/99704504; Bactrim/Septra is a drug used for treating and preventing PCP (Pneumocystis carinii pneumonia) and toxoplasmosis. However, people with HIV are more likely to develop hypersensitivity reactions to Bactrim/Septra. NAC (N-acetyl-cysteine) is being studied to determine if its detoxifying properties could reduce the risk o
Stroke in pediatric HIV infection [letter]: Pediatr Neurol. 1999 Aug;21(2):588. Unique Identifier : AIDSLINE MED/99392820; Legido A; Lischner HW; de Chadarevian JP; Katsetos CD
Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy.: Am J Reprod Immunol. 1999 Jul;42(1):1-13. Unique Identifier : AIDSLINE MED/99358392; Chaouat G; Cayol V; Mairovitz V; Dubanchet S; Hopital Antoine Beclere, Clamart, France.; PROBLEM: Th2 cytokines and Fas/Fas ligand interactions are proposed to be part of the placental barrier that contribute to the success of allogeneic pregnancy. To fully understand the role regulation of Th2 cytokines, we must isolate and identify the cells that produce them. We also need to assess the requirement for
[Improvement of lipodystrophy associated with protease inhibitors (news)]: Boll Chim Farm. 1999 Apr;138(4):192-3. Unique Identifier : AIDSLINE MED/99351231
Characteristics of persons with mental retardation and HIV/AIDS infection in a statewide Medicaid population.: Am J Ment Retard. 1999 Jul;104(4):356-63. Unique Identifier : AIDSLINE MED/99378956; Walkup J; Sambamoorthi U; Crystal S; Institute for Health, Health Care Policy, and Aging Research,; Rutgers University, New Brunswick, NJ 08901-1293, USA.; Walkup@rci.rutgers.edu; Very little is known about the characteristics of people with mental retardation who are infected with HIV. Using a datafile created by a match between the New Jersey HIV and AIDS Registry file through March 1996 and the New Jersey Medicaid eligibility file for the period August 1993 to March 1996, we identified the l
Descending necrotizing mediastinitis: a retrospective surgical experience.: Eur J Cardiothorac Surg. 1999 Aug;16(2):200-5. Unique Identifier : AIDSLINE MED/99413431; Sancho LM; Minamoto H; Fernandez A; Sennes LU; Jatene FB; Thoracic Surgery Division, Hospital das Clinicas, University of; Sao Paulo Medical Center, SP, Brazil.; OBJECTIVE: Descending necrotizing mediastinitis (DNM) is a primary complication of cervical or odontogenical infections that can spread to the mediastinum through the anatomic cervical spaces. We reviewed the last 10 years of our surgical experience in DNM and commented on early diagnosis and aggressive surgical treat
[A case of encephalomyeloneuritis and HTLV-I infection]: No To Shinkei. 1999 Aug;51(8):723-8. Unique Identifier : AIDSLINE MED/99407796; Tateyama M; Saito H; Okita N; Kobayashi K; Takase S; Itoyama Y; Department of Neurology, Konan Hospital, Japan.; The patient, a 65-year-old woman, had liver cirrhosis, and had blood transfusion at the age of 49 and 56. Early in September, 1989, she gradually developed numbness of the legs, staggering gait, and apathy with hallucination. In October, she became incontinent and unable to stand, and was admitted to Konan Hospital. O
Antigenic stimulation in T-cell cultures in cardiomyopathies: differences in cytokine profiles.: Eur J Immunogenet. 1999 Aug;26(4):285-91. Unique Identifier : AIDSLINE MED/99386343; Boura P; Lefkos N; Boudonas G; Kountouras J; Zacharioudaki E; Efthimiadis A; Tsapas G; 2nd Dept of Internal Medicine, Aristotle University of; Thessaloniki, Hippokration Hospital, Greece.; Immune-mediated mechanisms are involved in the pathogenesis of cardiomyopathies. In this study, we investigate which pattern of immune response (Th1 or Th2) lies behind these diseases by analysing the basic cytokines secreted from PHA-cultured T lymphocytes and determining what differences, if any, exist between dilat
Surveillance of sexually transmitted infections: fit for purpose? [comment]: Int J STD AIDS. 1999 Aug;10(8):493-4. Unique Identifier : AIDSLINE MED/99397698; Catchpole MA; Harris JR; Renton A; Hickman M; Communicable Disease Surveillance Centre, London, UK.
Palliative care and AIDS: 2--Gastrointestinal symptoms.: Int J STD AIDS. 1999 Aug;10(8):495-505; quiz 506-7. Unique Identifier : AIDSLINE MED/99397699; Meyer M; Princess Alice Hospice, Esher, Surrey, UK.; With the use of more intensive antiretroviral therapies (highly-active antiretroviral therapy, HAART) particularly in first world countries, reductions in the mortality and morbidity of HIV infection are being seen. However, though the prevalence of symptoms may change, symptom control does continue to be a problem fo
Universal prophylaxis for Chlamydia trachomatis and anaerobic vaginosis in women attending for suction termination of pregnancy: an audit of short-term health gains.: Int J STD AIDS. 1999 Aug;10(8):508-13. Unique Identifier : AIDSLINE MED/99397700; Blackwell AL; Emery SJ; Thomas PD; Wareham K; Singleton Hospital, Swansea NHS Trust, UK.; A previous study of infection and morbidity in 400 women attending for termination of pregnancy (TOP) had shown that 32 (8%) harboured cervical Chlamydia trachomatis and 112 (28%) had anaerobic (bacterial) vaginosis (AV). Fifty-three per cent of the women with preoperative C. trachomatis had AV. Thirty of the 32 women
Long-term immunotherapy in HIV infection, combined with short-term antiretroviral treatment.: Int J STD AIDS. 1999 Aug;10(8):514-21. Unique Identifier : AIDSLINE MED/99397701; Bratt G; Eriksson LE; Sandstrom E; Gilljam G; Hinkula J; Albert J; Redfield R; Wahren B; Karolinska Institute, Department of Gay Men's Health Clinic,; Venhalsan at Stockholm Soder Hospital, Sweden.; Forty asymptomatic HIV-infected individuals with CD4+ lymphocyte levels above 400x10(6)/l were immunized over 5 years with recombinant envelope glycoprotein gp160 (rgp160). After 5 years there was a trend towards more non-progressors in the immunized group as compared to the matched controls. Since immunizations could
Seroprevalence of herpes simplex virus type 2 antibodies in an STD clinic in Paris.: Int J STD AIDS. 1999 Aug;10(8):522-6. Unique Identifier : AIDSLINE MED/99397702; Janier M; Lassau F; Bloch J; Spindler E; Morel P; Gerard P; Aufrere A; STD Clinic, Hopital Saint-Louis, Paris, France.; Our objective was to evaluate the seroprevalence of herpes simplex virus (HSV)-2 and HSV-1 in a population of men and women attending the STD clinic of Hopital St-Louis (Paris, France ). Four hundred and eighty-seven patients (264 men and 223 women) were tested for HSV-2 and HSV-1 a
Diagnostic tests and specimens used to screen for Chlamydia trachomatis in genitourinary medicine clinics in the United Kingdom.: Int J STD AIDS. 1999 Aug;10(8):527-30. Unique Identifier : AIDSLINE MED/99397703; David LM; Department of Genitourinary Medicine, George Eliot Hospital,; Nuneaton, Warwickshire, UK. Loay.David@GEH-TR.WMIDS.NHS.UK; This questionnaire study looked at the diagnostics tests and specimens used to screen for Chlamydia trachomatis in UK genitourinary medicine (GUM) clinics. Replies were received from 70% (185/265) of clinics. Half used only one site to screen women. One-third took anal swabs from patients who had anal sex and 10% took
Post-traumatic stress disorder in female survivors of rape attending a genitourinary medicine clinic: a pilot study.: Int J STD AIDS. 1999 Aug;10(8):531-5. Unique Identifier : AIDSLINE MED/99397704; Petrak JA; Campbell EA; Ambrose King Centre, Royal London Hospital, Whitechapel, UK.; ambrose.king@dial.pipex.com; This study describes psychological symptomatology including post-traumatic stress disorder (PTSD) in 19 women attending a specialist sexual assault service within a genitourinary medicine (GUM) clinic. Women were interviewed within one year post-rape (mean = 12 weeks) using standardized questionnaires for PTSD and oth
Contact tracing for gonorrhoea in homosexual and heterosexual men.: Int J STD AIDS. 1999 Aug;10(8):536-8. Unique Identifier : AIDSLINE MED/99397705; Rogstad KE; Clementson C; Ahmed-Jushuf IH; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Central Sheffield University Hospitals Trust, UK.; We aimed to determine whether the success of partner notification for gonorrhoea in men was affected by sexual orientation. Analysis of standard clinic and health adviser records of all male patients found to be infected with gonorrhoea between October 1992 and September 1993 were carried out. Of the 278 cases of gono
Nursing in genitourinary medicine: 10 years on from the Monks Report. The membership of GUNA. Genito-Urinary Nurses Association.: Int J STD AIDS. 1999 Aug;10(8):539-42. Unique Identifier : AIDSLINE MED/99397706; Sutton A; Kingsland T; Ross S; Burke M; Gray T; Jenkins J; GUNA, HIV Liaison Nurse, Guest Hospital, Dudley, West Midlands,; UK.; Various reports and surveys since 1988 have highlighted differences in gradings and diversity of roles and responsibilities of nurses in genitourinary medicine (GUM). In addition there was no method of defining how many nurses work in the speciality. Therefore the Genito-Urinary Nurses Association (GUNA) undertook a s
HIV/STD: the women to blame? Knowledge and attitudes among STD clinic attendees in the second decade of HIV/AIDS.: Int J STD AIDS. 1999 Aug;10(8):543-7. Unique Identifier : AIDSLINE MED/99397707; Rakwar J; Kidula N; Fonck K; Kirui P; Ndinya-Achola J; Temmerman M; International Centre for Reproductive Health, University of; Ghent, Belgium.; We aimed to determine the knowledge and attitudes towards HIV/STDs among women attending an STD clinic by interviewing 520 randomly selected women. Nearly all had heard of HIV/AIDS/STDs, with posters, pamphlets and the radio being the main source of their information. The years of schooling was the only predictive fac
Male polyurethane condoms do not enhance brief HIV-STD risk reduction interventions for heterosexually active men: results from a randomized test of concept.: Int J STD AIDS. 1999 Aug;10(8):548-53. Unique Identifier : AIDSLINE MED/99397708; Kalichman SC; Cherry C; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA.; The current study examined the effects of a brief HIV risk reduction intervention for men. Participants were recruited (n = 108) from an urban public health clinic and randomly assigned to one of 3 experimental intervention conditions: (1) 3 h HIV-STD risk reduction behavioural skills building latex condom interventio
An audit of diagnostic coding in genitourinary medicine clinics. Trent Region Genitourinary Medicine Audit Group [see comments]: Int J STD AIDS. 1999 Aug;10(8):554-6. Unique Identifier : AIDSLINE MED/99397709; Carlin EM; Rogstad KE; Department of Genitourinary Medicine, The King's Mill Centre for; Health Care Services, Sutton-in-Ashfield, Nottinghamshire, UK.; The KC60 diagnostic code information provides an epidemiological monitor of sexually transmitted infection (STI) and a means of standardizing clinical workload in genitourinary medicine (GUM) departments. We aimed to assess the coding process and its uniformity within the Trent region by means of a confidential self-a
Nandrolone decanoate; use in HIV-associated lipodystrophy syndrome: a pilot study [letter]: Int J STD AIDS. 1999 Aug;10(8):558. Unique Identifier : AIDSLINE MED/99397710; Gold J; Batterham M
vpu transmembrane peptide structure obtained by site-specific fourier transform infrared dichroism and global molecular dynamics searching.: Biophys J. 1999 Sep;77(3):1594-601. Unique Identifier : AIDSLINE MED/99396619; Kukol A; Arkin IT; Cambridge Center for Molecular Recognition, Department of; Biochemistry, University of Cambridge, Cambridge CB2 1GA,; England.; The recently developed method of site-directed Fourier transform infrared dichroism for obtaining orientational constraints of oriented polymers is applied here to the transmembrane domain of the vpu protein from the human immunodeficiency virus type 1 (HIV-1). The infrared spectra of the 31-residue-long vpu peptide r
Proteolytic activity in infected and noninfected insect cells: degradation of HIV-1 Pr55gag particles.: Biotechnol Bioeng. 1999 Oct 20;65(2):133-43. Unique Identifier : AIDSLINE MED/99387939; Cruz PE; Martins PC; Alves PM; Peixoto CC; Santos H; Moreira JL; Carrondo MJ; Instituto de Biologia Experimental e Tecnologica/Instituto de; Tecnologia Quimica e Biologica, IBET/ITQB, Apartado 12, P-2780; Oeiras, Portugal.; In this work the proteolytic activity in the supernatant and inside insect cells in culture was evaluated for different multiplicities of infection (MOI) and times of infection (TOI). Several methods to detect proteolytic activity in insect cells were tested and that using fluorescein thiocyanite-casein as a substrate
Signals involved in CD4/CD8 lineage commitment: current concepts and potential mechanisms.: Semin Immunol. 1999 Aug;11(4):273-81. Unique Identifier : AIDSLINE MED/99371715; Singer A; Bosselut R; Bhandoola A; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Building 10 Room 4B36, Bethesda,; Maryland 20892, USA.; A competent immune system requires that mature T cells express TCR and CD4/CD8 coreceptors with matching MHC specificities. Such matching of TCR and coreceptor specificity is induced in the thymus at the CD4(+)8(+)stage of development and is referred to as lineage commitment. The process by which immature CD4(+)8(+)th
Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s).: Semin Immunol. 1999 Aug;11(4):293-303. Unique Identifier : AIDSLINE MED/99371717; Poussier P; Julius M; Department of Medicine, The Arthritis and Immune Disorder; Research Centre, University of Toronto, Toronto, Ontario, M5S; 1A8, Canada.; The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCRgammadelta or T
Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes.: Blood. 1999 Sep 15;94(6):1890-8. Unique Identifier : AIDSLINE MED/99408728; Chantry D; Romagnani P; Raport CJ; Wood CL; Epp A; Romagnani S; Gray PW; ICOS Corp, Bothell, WA, USA.; Macrophage-derived chemokine (MDC) is a recently identified CC chemokine that is a potent chemoattractant for dendritic cells, natural killer (NK) cells, and the Th2 subset of peripheral blood T cells. In normal tissues, MDC mRNA is expressed principally in the thymus. Immunohistochemical analysis performed on 5 human
CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.: Unique Identifier : AIDSLINE MED/99408729; Blanpain C; Migeotte I; Lee B; Vakili J; Doranz BJ; Govaerts C; Vassart G; Doms RW; Parmentier M; CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV). Chemokines constitute a rapidly growing family of proteins and
Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils.: Blood. 1999 Sep 15;94(6):2065-71. Unique Identifier : AIDSLINE MED/99408747; Jundt F; Anagnostopoulos I; Bommert K; Emmerich F; Muller G; Foss HD; Royer HD; Stein H; Dorken B; Universitatsklinikum Charite, Robert-Rossle-Klinik, Humboldt; University of Berlin, Berlin, Germany. fjundt@mdc-berlin.de; Hodgkin s disease is histopathologically characterized by the relative scarcity of neoplastic Hodgkin and Reed-Sternberg cells and for yet unknown reasons by an abundant reactive background of T lymphocytes and often eosinophils. Eotaxin is a CC-chemokine attracting eosinophils and T helper 2 (Th2) cells in allergic i
A novel Epstein-Barr virus-like virus, HV(MNE), in a Macaca nemestrina with mycosis fungoides.: Blood. 1999 Sep 15;94(6):2090-101. Unique Identifier : AIDSLINE MED/99408750; Rivadeneira ED; Ferrari MG; Jarrett RF; Armstrong AA; Markham P; Birkebak T; Takemoto S; Johnson-Delaney C; Pecon-Slattery J; Clark EA; Franchini G; National Cancer Institute, Basic Research Laboratory, Bethesda,; MD; the Leukaemia Research Fund Virus Centre, Department of; Veterinary Pathology, University of Glasgow, Glasgow, UK.; Epstein-Barr virus (EBV) infection of humans has been associated with the development of lymphoid malignancies mainly of B-cell lineage, although occasionally T-cell lymphomas have been reported. We describe here the characterization of a novel EBV-like virus (HV(MNE)) isolated from a simian T-cell lymphotropic virus
An interdisciplinary mock trial involving pharmacy, law, and ethics.: Ann Pharmacother. 1999 Jul-Aug;33(7-8):850-8. Unique Identifier : AIDSLINE MED/99394827; Broeseker AE; Jones MM; Department of Pharmacy Practice, McWhorter School of Pharmacy,; Samford University, Birmingham, AL 35229, USA.; aebroese@samford.edu; OBJECTIVE: To describe an innovative, interdisciplinary approach to illustrate the relationship between healthcare ethics and law. METHODS: A mock trial was created for students enrolled in the Samford University McWhorter School of Pharmacy and Department of Paralegal Education. The trial served as the starting point
Hyperlipidemia associated with protease inhibitor therapy.: Ann Pharmacother. 1999 Jul-Aug;33(7-8):859-63. Unique Identifier : AIDSLINE MED/99394828; Echevarria KL; Hardin TC; Smith JA; South Texas Veterans Health Care System, San Antonio, USA.; kechev@parknet.pmh.org; OBJECTIVE: To report a case of extreme hyperlipidemia associated with protease inhibitor-based antiretroviral therapy and review the relevant literature concerning lipid abnormalities with HIV infection and antiretroviral therapy. CASE SUMMARY: A 35-year-old HIV-infected man developed a serum cholesterol of 1472 mg/dL
Focal hepatic lesions on magnetic resonance imaging induced by trimethoprim/sulfamethoxazole in HIV infection [letter]: Ann Pharmacother. 1999 Sep;33(9):1007-8. Unique Identifier : AIDSLINE MED/99420256; Takahashi T; Taguchi H; Nakamura T; Yoshikawa K; Iwamoto A
Discontinuation rates for protease inhibitor regimens containing ritonavir 600 mg versus ritonavir 400 mg plus saquinavir 400 mg.: Ann Pharmacother. 1999 Sep;33(9):899-905. Unique Identifier : AIDSLINE MED/99420236; Rublein JC; Eron JJ Jr; Butts JD; Raasch RH; University of North Carolina Hospitals and Clinics, Chapel Hill; 27514, USA.; OBJECTIVE: A retrospective study was performed to determine whether twice-daily ritonavir 400 mg plus twice-daily saquinavir 400 mg (ritonavir 400/saquinavir 400) was better tolerated than ritonavir 600 mg twice daily (ritonavir 600). A secondary objective was to determine whether the rate of discontinuation due to th
Pharmacologic considerations for therapeutic success with antiretroviral agents.: Ann Pharmacother. 1999 Sep;33(9):989-95. Unique Identifier : AIDSLINE MED/99420253; Fletcher CV; Department of Experimental and Clinical Pharmacology, University; of Minnesota, Minneapolis 55455, USA. fletc001@tc.umn.edu; OBJECTIVE: To explore pharmacologic elements that contribute to therapeutic success with agents used for the treatment of HIV infection. DATA SOURCES: Primary articles were identified through MEDLINE (January 1990-January 1999) and secondary sources. Conference abstracts were selected by review of published proceeding
Pattern of defervescence in response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis and advanced human immunodeficiency virus infection.: J Formos Med Assoc. 1999 Aug;98(8):550-5. Unique Identifier : AIDSLINE MED/99432526; Hsieh SM; Sheng WH; Chen MY; Hung CC; Chang SC; Section of Infectious Disease, National Taiwan University; Hospital, Taipei.; The pattern of fever response to empiric anti-tuberculosis therapy in patients with tuberculosis (TB) and human immunodeficiency virus (HIV) infection, and the relationship between fever response patterns and anti-TB drug susceptibility profiles of Mycobacterium tuberculosis isolates are rarely described. In this stud
Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study. Swiss HIV Cohort Study.: BMJ. 1999 Jul 3;319(7201):23-4. Unique Identifier : AIDSLINE MED/99321598; Ledergerber B; Telenti A; Egger M; Division of Infectious Diseases, Department of Medicine,; University Hospital Zurich, CH-8091 Zurich, Switzerland.
UK inquiry should establish why contaminated blood products were given to people with haemophilia [letter]: BMJ. 1999 Jul 3;319(7201):52-3. Unique Identifier : AIDSLINE MED/99321611; Pappenheim K
Targets for antenatal HIV testing announced.: Commun Dis Rep CDR Wkly. 1999 Aug 20;9(34):297, 300. Unique Identifier : AIDSLINE MED/99432495
Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease.: Am J Respir Crit Care Med. 1999 Sep;160(3):866-72. Unique Identifier : AIDSLINE MED/99403228; Tanaka E; Kimoto T; Tsuyuguchi K; Watanabe I; Matsumoto H; Niimi A; Suzuki K; Murayama T; Amitani R; Kuze F; Department of Infectious Diseases, Faculty of Medicine, Kyoto; University, Kyoto, Japan.; We have investigated the efficacy of a clarithromycin-containing four-drug regimen for Mycobacterium avium complex (MAC) pulmonary disease in 46 patients without acquired immunodeficiency syndrome (AIDS). The patients were 14 males and 32 females with a mean age of 60.9 +/- 11.5 yr. Patients received 10 mg/kg/d of cla
Induction of lymphocytic inflammatory changes in lung interstitium by human T lymphotropic virus type I.: Am J Respir Crit Care Med. 1999 Sep;160(3):995-1000. Unique Identifier : AIDSLINE MED/99403248; Kawakami K; Miyazato A; Iwakura Y; Saito A; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; kawakami@med.u-ryukyu.ac.jp; Human T lymphotropic virus type I (HTLV-I) is the etiological agent of adult T cell leukemia, and reports suggest that several other clinical conditions are associated with HTLV-I infection, including myelopathy and inflammatory pulmonary diseases. However, the clinical entity of HTLV-I-associated lung disease remains
[The effect of nutritional management on the mortality of malnourished children, uninfected and infected with the human immunodeficiency virus]: Sante. 1999 May-Jun;9(3):163-7. Unique Identifier : AIDSLINE MED/99407069; Beau JP; Imboua-Coulibaly L; Du Lou AD; IRD, 04 BP 293, Abidjan 04, Cote d'Ivoire.; Weight loss is a major complication in children infected with HIV. Very few studies have focused on the nutritional management of malnourished HIV-positive children, particularly in developing countries, although there have been some studies in adults. Therefore, the aim of this retrospective study was to evaluate, as
[Maternal HIV infection and the anthropometric characteristics of children at birth in Burkina Faso. DITRAME Study Group]: Sante. 1999 May-Jun;9(3):173-7. Unique Identifier : AIDSLINE MED/99407071; Sombie I; Nacro B; Tiendrebeogo S; Dao B; Cartoux M; Meda N; Ky-Zerbo O; Dabis F; Mandelbrot L; Van de Perre P; Centre Muraz, OCCGE, 01 BP 153, Bobo-Dioulasso 01, Burkina Faso.; The aim of this study was to investigate the relationship between maternal HIV status and the anthropometric characteristics of children at birth. A cross-sectional study was conducted in Bobo-Dioulasso from January 1995 to May 1996. We included all mother-child pairs seen postpartum for whom the HIV status of the mot
[Representations of mother to child transmission of AIDS, perception of the risk and health information messages in Burkina Faso]: Sante. 1999 May-Jun;9(3):195-9. Unique Identifier : AIDSLINE MED/99407075; Taverne B; Institut de recherche pour le developpement (IRD), Laboratoire; population environnement, Universite de Provence, place; Victor-Hugo, 13391 Marseille Cedex 3, France.; In Burkina Faso , in rural Mossi areas, popular contemporary representations of the transmission of HIV from mother to child are based on the idea that the disease is in the blood and that the fetus is conceived by mixing the blood of its parents. Infection of the child is seen
HHV-8 and multistep tumorigenesis [letter]: Trends Microbiol. 1999 Aug;7(8):310-2. Unique Identifier : AIDSLINE MED/99362807; Ensoli B; Sturzl M
Cellular immune responses of a Senegalese community recently exposed to Schistosoma mansoni: correlations of infection level with age and inflammatory cytokine production by soluble egg antigen-specific cells.: Trop Med Int Health. 1999 Aug;4(8):530-43. Unique Identifier : AIDSLINE MED/99428864; Marguerite M; Gallissot MC; Diagne M; Moreau C; Diakkhate MM; Roberts M; Remoue F; Thiam A; Decam C; Rogerie F; Cottrez F; Neyrinck JL; Butterworth AE; Sturrock RF; Piau JP; Daff B; Niang M; Wolowczuk I; Riveau G; Auriault C; Capron A; Laboratoire de SOR, Programme ESPOIR, Saint-Louis, Senegal.; A recently reported epidemic of Schistosoma mansoni infection in Senegal provided an opportunity to study the dynamics of the development of immunity to human schistosomiasis. We report here on the cell-mediated immune response in a population of 99 females and 95 males, with part
[Effect of dietary arginine on peripheral blood Th/Ts ratio and survival rate in severe burned rats]: Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1997 May;13(3):199-201. Unique Identifier : AIDSLINE MED/99381307; Chen Y; Fang Y; Ge S; Burns Center of People's Liberation Army, Changhai Hospital,; Second Military Medical University, Shanghai.; The effect of supplemental dietary arginine on dynamic changes in peripheral blood Th/ Ts ratio and survival rate were studied in burned rats (30% TBSA III degree). The results are as follows: 1. Th/Ts ratio dropped on the 3rd day and showed a trough value 10 days postburn. 2. Arginine could prevent the falling of Th/
Failure of double protease inhibitor therapy as a salvage therapy for HIV-infected patients resistant to conventional triple therapy.: Eur J Med Res. 1999 Jul 28;4(7):271-4. Unique Identifier : AIDSLINE MED/99356021; Rockstroh JK; Altfeld M; Kupfer B; Kaiser R; Fatkenheuer G; Salzberger B; Schneweis KE; Spengler U; Department of Medicine, Sigmund-Freud-Strasse 25, D-53105 Bonn,; Germany. EurJMedRes@t-online.de; A therapeutic dilemma arises once HIV-infected patients develop a break-through of HIV-replication under potent antiretroviral therapy. Therefore, we studied whether patients (n = 12) who failed double nucleoside reverse transcriptase (NRTI) plus indinavi
Dopamine systems in human immunodeficiency virus-associated dementia.: Neuropsychiatry Neuropsychol Behav Neurol. 1999 Jul;12(3):184-92. Unique Identifier : AIDSLINE MED/99383803; Lopez OL; Smith G; Meltzer CC; Becker JT; Department of Neurology, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; OBJECTIVE: To provide an update of the neurobiologic basis of human immunodeficiency virus (HIV)-associated dementia (HAD), with emphasis on the relationship between dopamine (DA) system dysfunction and behavioral manifestations. BACKGROUND: HIV has a propensity to invade subcortic
[AIDS and sexually transmitted diseases in the Americas (letter)]: Rev Panam Salud Publica. 1999 Sep;6(3):215-9. Unique Identifier : AIDSLINE MED/99446297; This document provides a brief review of the situation of HIV/aids and of sexually transmitted infections (STIs) in the Americas. Among the subjects covered are appropriate care models for HIV/aids, including access to antiretroviral drugs; preventing transmission from mother to child; improved activities for preventi
Graft-facilitating doses of ex vivo activated gammadelta T cells do not cause lethal murine graft-vs.-host disease.: Biol Blood Marrow Transplant. 1999;5(4):222-30. Unique Identifier : AIDSLINE MED/99392771; Drobyski WR; Majewski D; Hanson G; Department of Medicine, Medical College of Wisconsin, Milwaukee,; USA.; The purpose of this study was to examine the ability of gamma(delta) T cells to cause graft-vs.-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) and to determine whether these cells offered any therapeutic advantages relative to alphabeta T cells. Due to the paucity of naive gamma(delta) T cells
Effect of tauroursodeoxycholic acid on ALT, GGT and viral load in patients with hepatitis C virus-related chronic hepatitis with reference to the genotype [letter]: Ital J Gastroenterol Hepatol. 1999 Jun-Jul;31(5):427. Unique Identifier : AIDSLINE MED/99399626; Belloni G; Ferrari L; Balduzzi C; Barbieri F; Insolia R; Klersy C
An improved method for dissociation and aggregate culture of human fetal brain cells in serum-free medium.: Brain Res Brain Res Protoc. 1999 Jul;4(2):156-64. Unique Identifier : AIDSLINE MED/99377289; Barnea A; Roberts J; Department of Obstetrics and Gynecology, The University of Texas; Southwestern Medical Center at Dallas, Dallas, TX 75235-9032,; USA. ayalla.barnea@email.swmed.edu; Moscona, in the early sixties [A.A. Moscona, Recombination of dissociated cells and the development of cell aggregates, in: B.M. Willmer (Ed.), Cells and Tissues in Culture, Academic Press, New York, 1965, pp. 489-529.] [16], discovered that aggregation of dissociated cells is a property of embryonal cells. Several fe
[HIV-1 env glycoprotein gp120 and gp160 expressed in vaccinia virus system and their antigenicity analysis]: Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1997 Apr;19(2):120-6. Unique Identifier : AIDSLINE MED/99382882; Chen Y; Garcia R; Baralle FE; Institute of Medical Biology, CAMS, Kunming.; Human immunodeficiency virus type 1 (HIV-1) is the principal causative agent of AIDS that is an important concerns to human being health. The most important antigen of HIV-1 is its envelope glycoprotein gp160 (gp120 + gp41). By means of genetic engineering techniques, HIV-1 gp120 and gp160 were constructed and express
HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness.: J Biomed Sci. 1999 Sep-Oct;6(5):298-305. Unique Identifier : AIDSLINE MED/99425436; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; Amsterdam, The Netherlands. b.berkhout@amc.uva.nl; The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to
Purification of RBF-2, a transcription factor with specificity for the most conserved cis-element of naturally occurring HIV-1 LTRs.: J Biomed Sci. 1999 Sep-Oct;6(5):320-32. Unique Identifier : AIDSLINE MED/99425439; Estable MC; Hirst M; Bell B; O'Shaughnessy MV; Sadowski I; Department of Biochemistry and Molecular Biology, Faculty of; Medicine, University of British Columbia, Vancouver, B.C.,; Canada.; The combination of high turnover and error-prone reverse transcription results in naturally occurring human immunodeficiency virus-1 long terminal repeats that differ considerably from the prototype sequence. Although no transcription-factor-binding site escapes mutation, the only mutated site that appears to be invar
Organization of HIV-1 pol is critical for Pol polyprotein processing.: J Biomed Sci. 1999 Sep-Oct;6(5):333-41. Unique Identifier : AIDSLINE MED/99425440; Chang YY; Yu SL; Syu WJ; Institute of Microbiology and Immunology, National Yang Ming; University, Taipei, Taiwan, ROC.; The HIV pol sequentially encodes protease (PR), reverse transcriptase (RT), and integrase (IN) from the 5 -3 direction. We explored the significance of this gene arrangement. All six possible gene dispositions were examined. In two situations where PR was removed from the leading place and no two genes were in their
Novel vaginal controlled-delivery systems incorporating coprecipitates of nonoxynol-9.: Pharm Dev Technol. 1999 Aug;4(3):421-30. Unique Identifier : AIDSLINE MED/99363132; Digenis GA; Nosek D; Mohammadi F; Darwazeh NB; Anwar HS; Zavos PM; Division of Medicinal Chemistry and Pharmaceutics, College of; Pharmacy, University of Kentucky, Lexington 40536-0082, USA.; The purpose of this study was to formulate Nonoxynol-9 (N-9) into a solid coprecipitate form which can be used in preparing pharmaceutically attractive and nonirritating vaginal controlled-release delivery systems (DDSs) such as gelatin capsules (HGC) and tablets. N-9 was coprecipitated with polyvinylpyrrolidone (PVP)
Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease.: Bioorg Med Chem Lett. 1999 Aug 16;9(16):2431-6. Unique Identifier : AIDSLINE MED/99404532; Shultz MD; Chmielewski J; Department of Chemistry, Purdue University, West Lafayette, IN; 47907, USA.; The importance of each side chain of a cross-linked interfacial peptide inhibitor of HIV-1 protease was evaluated using an alanine scanning approach. Whereas the parent inhibitor has an IC50 value of 350 nM, values for the mutations reported here range from 280-9200 nM. The relative importance or each residue was thus
Motor-evoked potentials: unusual findings.: Clin Neurophysiol. 1999 Sep;110(9):1641-5. Unique Identifier : AIDSLINE MED/99406146; Ugawa Y; Kanazawa I; Department of Neurology, Graduate School of Medicine, University; of Tokyo, Japan. ugawa-tky@umin.ac.jp; OBJECTIVE: The aims of this study were to present rare findings of motor evoked potentials (MEPs) in 3 patients with spastic paraparesis and to show that careful interpretation is indispensable in experiments done with very high intensity stimulation. METHODS: The conduction along several segments of the descending tr
Atypical presentation of herpes simplex virus in a patient with chronic lymphocytic leukemia.: Cutis. 1999 Aug;64(2):123-5. Unique Identifier : AIDSLINE MED/99396838; Brown TS; Callen JP; Department of Medicine, University of Louisville, Kentucky 40202,; USA.; Perianal infections caused by herpes simplex virus are common in immunocompromised patients. The cutaneous presentation in these patients is often atypical, overlaps with the clinical features of other diseases, poses a difficulty in diagnosis, and responds poorly to treatment. An immunocompromised patient with chroni
An infectious mononucleosis-like syndrome induced by minocycline: a third pattern of adverse drug reaction.: Cutis. 1999 Aug;64(2):91-6. Unique Identifier : AIDSLINE MED/99396830; Lupton JR; Figueroa P; Tamjidi P; Berberian BJ; Sulica VI; Department of Dermatology, George Washington University Medical; Center, Washington, DC 20037, USA.; A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne. His illness was also characterized by a palpable spleen tip, marked lower extremity and scrotal edema, and generalized lymph
Management of multidrug-resistant tuberculosis.: Chemotherapy. 1999;45 Suppl 2:3-11. Unique Identifier : AIDSLINE MED/99380058; Iseman MD; Clinical Mycobacteriology Service, The Division of Infectious; Diseases, National Jewish Medical and Research Center, Denver, CO; 80206, USA.; Drug-resistant tuberculosis (TB) originally is the product of inadequate therapy; this may entail noncompliance with treatment, interrupted drug supplies, or inappropriate prescription. Patients may sequentially acquire resistance to several drugs through repetition of this process. Loss of activity of the major drugs
Is inhaled corticosteroid useful as adjunctive management in tuberculous pyrexia?: Drugs Exp Clin Res. 1999;25(4):179-84. Unique Identifier : AIDSLINE MED/99370863; Yew WW; Chau CH; Lee J; Leung CK; Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China.; Systemic corticosteroid is currently the standard adjunctive therapy for tuberculous pyrexia. A preliminary prospective open study to examine the efficacy of inhaled budesonide at a dose of 2,400 micrograms daily in the management of this condition was performed. Out of nine non-HIV infected patients with tuberculous
Drug and alcohol consumption and sexual risk behaviour among young adults: results from a national survey.: Drug Alcohol Depend. 1999 Aug 2;56(1):47-53. Unique Identifier : AIDSLINE MED/99389188; Castilla J; Barrio G; Belza MJ; de la Fuente L; Secretaria del Plan Nacional sobre Sida, Ministerio de Sanidad y; Consumo, Madrid, Spain. jcastill@isciii.es; To study the association of the consumption of alcohol and other psychoactive drugs with sexual risk behaviour for HIV infection, data from a representative sample of the Spanish population aged 18-39 years were analysed. A national household survey was carried out in 1996 using a combination of face-to-face interview
Methadone treatment in Spain, 1994.: Drug Alcohol Depend. 1999 Aug 2;56(1):61-6. Unique Identifier : AIDSLINE MED/99389190; Domingo-Salvany A; Perez K; Torrens M; Bravo MJ; Anto JM; Alonso J; Institut Municipal d'Investigacio Medica, Barcelona, Spain.; adomingo@imim.es; The objective of this study was to describe the methadone treatment (MT) network in Spain , and to evaluate compliance with criteria known to influence the spread of human immunodeficiency virus (HIV). During the last 3 months of 1994, a mailed questionnaire was sent to the coordinat
[HIV: fusion inhibitors as the new therapeutic approach (news)]: Dtsch Med Wochenschr. 1999 Sep 10;124(36):A19-20. Unique Identifier : AIDSLINE MED/99436734
[A new drug in HIV infections authorized (news)]: Dtsch Med Wochenschr. 1999 Sep 10;124(36):A20. Unique Identifier : AIDSLINE MED/99436735
Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct.: Unique Identifier : AIDSLINE MED/99421686; Adelson ME; Martinand-Mari C; Iacono KT; Muto NF; Suhadolnik RJ; Fels Institute for Cancer Research, Department of Biochemistry,; Temple University School of Medicine, Philadelphia, PA, USA.; Current strategies against the human immunodeficiency virus type 1 (HIV-1), including nucleoside analogues and protease inhibitors , have limited effectiveness as shown by the evolution of resistant retroviral strains and the presence of latent HIV-1 reservoirs. Ther
Effect of substrate residues on the P2' preference of retroviral proteinases.: Eur J Biochem. 1999 Sep;264(3):921-9. Unique Identifier : AIDSLINE MED/99421700; Boross P; Bagossi P; Copeland TD; Oroszlan S; Louis JM; Tozser J; Department of Biochemistry, University Medical School of Debreen,; Hungary.; The substrate sequence requirements for preference toward P2 Glu residue by human immunodeficiency virus type 1 (HIV-1) proteinase were studied in both the matrix protein/ capsid protein (MA/CA) and CA/p2 cleavage site sequence contexts. These sequences represent typical type 1 (-aromatic*Pro-) and type 2 (-hydrophob
Pseudomonas aeruginosa bacteremia in patients infected with human immunodeficiency virus type 1.: Eur J Clin Microbiol Infect Dis. 1999 Jul;18(7):473-7. Unique Identifier : AIDSLINE MED/99409749; Vidal F; Mensa J; Martinez JA; Almela M; Marco F; Gatell JM; Richart C; Soriano E; Jimenez de Anta MT; Department of Internal Medicine, Hospital Universitari de; Tarragona JOAN XXIII, Faculty of Medicine and Health Sciences,; University Rovira i Virgili, Tarragona, Spain.; fvidal@galenics.com; A prospective analysis of 43 episodes of Pseudomonas aeruginosa bacteremia in HIV-1-infected subjects was performed and the results compared with the incidence and outcome of Pseudomonas aeruginosa bacteremia in other high-risk patients, such as transplant recipients, leukemia patients, or patients hospitalized in the
Candidemia in HIV-infected subjects.: Eur J Clin Microbiol Infect Dis. 1999 Jul;18(7):478-83. Unique Identifier : AIDSLINE MED/99409750; Tumbarello M; Tacconelli E; de Gaetano Donati K; Morace G; Fadda G; Cauda R; Department of Infectious Diseases, Catholic University, Rome,; Italy.; The epidemiological features of 37 episodes of candidemia in HIV-infected subjects were analysed in a retrospective matched case-control study conducted over an 8-year period (1990-1997). Univariate analysis identified eight risk factors that were significantly associated with candidemia (P
Favourable effect of chemotherapy on clinical symptoms and human herpesvirus-8 DNA load in a patient with Kaposi's sarcoma presenting with fever and anemia.: Eur J Clin Microbiol Infect Dis. 1999 Jul;18(7):499-502. Unique Identifier : AIDSLINE MED/99409754; Prins JM; Sol CJ; Renwick N; Goudsmit J; Veenstra J; Reiss P; Department of Internal Medicine, Academic Medical Center,; University of Amsterdam, The Netherlands. j.m.prins@amc.uva.nl; The case of a patient infected with human immunodeficiency virus type 1 (HIV-1) with Kaposi s sarcoma who presented with fever of unknown origin, severe anemia, thrombocytopenia and hypoalbuminemia but only limited involvement of the skin is presented. Chemotherapy directed at Kaposi s sarcoma resulted in resolution o
Sensory dysfunction in HTLV-I-associated myelopathy/tropical spastic paraparesis. A comprehensive neurophysiological study.: Eur Neurol. 1999 Jul;42(1):17-22. Unique Identifier : AIDSLINE MED/99323869; Castillo JL; Cea JG; Verdugo RJ; Cartier L; Department of Neurology, Hospital del Salvador, Faculty of; Medicine, University of Chile, Santiago, Chile.; We performed a comprehensive clinical and neurophysiological evaluation of function of the large- and small-caliber afferent pathways in 29 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Sensory symptoms, particularly cutaneous paresthesias, were present in 11 (37.9%) patients. On e
Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-1alpha/LD78alpha.: FEBS Lett. 1999 Aug 27;457(2):219-22. Unique Identifier : AIDSLINE MED/99402926; Xin X; Shioda T; Kato A; Liu H; Sakai Y; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Tokyo, Japan.; We compared the anti-HIV-1 activity of CC-chemokine LD78beta with that of MIP-1alpha, another CC-chemokine which shows 94% sequence homology with LD78beta. Despite its close similarity to MIP-1alpha, the anti-HIV-1 activity of LD78beta appeared to be nearly 10 times higher than that of MIP-1alpha. Mutagenesis of MIP-1
Inhibition of infection of incoming HIV-1 virus by RNA-cleaving DNA enzyme.: FEBS Lett. 1999 Sep 17;458(2):151-6. Unique Identifier : AIDSLINE MED/99412182; Zhang X; Xu Y; Ling H; Hattori T; Division of Allergy and Infectious Diseases, Department of; Internal Medicine, Graduate School of Medicine, Tohoku; University, Sendai, Japan.; Nine different DNA enzymes (DzV3-n, n=1-9) targeting the V3 loop region of HIV-1 HXB2 were synthesized. One of those, DzV3-9, efficiently cleaved the target in the conserved sequence in the RNA transcript in vitro. DzV3-9 was stable in the cells and inhibited replication of both NL432 and SF162 strains in U87 cells ex
Differential down-regulation of CD95 or CD95L in chronically HIV-infected cells of monocytic or lymphocytic origin: cellular studies and molecular analysis by quantitative competitive RT-PCR.: FEBS Lett. 1999 Sep 17;458(2):209-14. Unique Identifier : AIDSLINE MED/99412194; Pinti M; Pedrazzi J; Benatti F; Sorrentino V; Nuzzo C; Cavazzuti V; Biswas P; Petrusca DN; Mussini C; De Rienzo B; Cossarizza A; Department of Internal Medicine, Infectious Disease Clinics,; University of Modena, Reggio Emilia School of Medicine, Italy.; We analysed the expression of CD95/CD95L in two widely used models for studying the cellular effects of chronic infection with human immunodeficiency virus type 1 (HIV-1), i.e. ACH-2 cells, derived from the lymphocytic cell line A301, and U1, derived from monocytic U937 cells. A301 and ACH-2 mounted the same amount of
Calorie restriction increases Fas/Fas-ligand expression and apoptosis in murine splenic lymphocytes.: FEBS Lett. 1999 Sep 17;458(2):231-5. Unique Identifier : AIDSLINE MED/99412198; Reddy Avula CP; Muthukumar A; Fernandes G; Division of Clinical Immunology, Department of Medicine, The; University of Texas Health Science Center at San Antonio; 78229-3900, USA.; One-month-old male ICR mice were fed a nutritionally adequate, semipurified diet, either ad libitum (AL) or calorie restricted (CR) (40% less food) for 6 months and were killed to obtain spleens. Flow cytometric analysis revealed increased proportions of both CD4+ and CD8+ T cells in CR-fed mice compared to AL-fed mic
Isolation of two subpopulations of Mycobacterium avium within human macrophages.: FEMS Microbiol Lett. 1999 Sep 1;178(1):19-26. Unique Identifier : AIDSLINE MED/99413216; Bermudez LE; Wu M; Miltner E; Inderlied CB; Kuzell Institute for Arthritis and Infectious Diseases,; California Pacific Medical Center Research Institute, San; Francisco 94115, USA. luizb@cooper.cpmc.org; Mycobacterium avium is an intracellular pathogen that is associated with disseminated infection in acquired immunodeficiency syndrome (AIDS) patients. Human monocyte-derived macrophages were infected with M. avium strain 101 and a quinolone (Bay y 3118) was used at 8 micrograms ml-1, a concentration that kills growing
[Obstetric characteristics of adolescent pregnancy]: Unique Identifier : AIDSLINE MED/99434405; Villanueva LA; Perez Fajardo MM; Martinez Ayala H; Garcia Lara E; Hospital General Dr. Manuel Gea Gonzalez, Secretaria de Salud,; Mex., D.F.; Obstetrical characteristics of pregnant adolescents. The aim of the present study was to determine the obstetrical characteristics of pregnant adolescents and to evaluate if the high risk comes from biological factors associate to their age or not. The obstetrical complications and the perinatal results were not diffe
Atypical clinical presentation of visceral leishmaniasis.: Haematologica. 1999 Aug;84(8):750. Unique Identifier : AIDSLINE MED/99388046; Hernandez JA; Bosch MA; Sauca G; Servei de Laboratori, Ctra Cicera s/n, 08304 Mataro, Barcelona,; Spain.
Role of Leishmania donovani and its lipophosphoglycan in CD4+ T-cell activation-induced human immunodeficiency virus replication.: Infect Immun. 1999 Oct;67(10):5258-64. Unique Identifier : AIDSLINE MED/99426822; Wolday D; Akuffo H; Demissie A; Britton S; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; Chronic immune activation by coinfecting pathogens has been suggested as a cofactor in human immunodeficiency virus (HIV) disease progression, particularly in the setting of developing countries. Here, we used in vivo-infected mononuclear cells to examine the role of the protozoan parasite Leishmania donovani and its
Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid.: Infect Immun. 1999 Oct;67(10):5345-51. Unique Identifier : AIDSLINE MED/99426833; San Mateo LR; Toffer KL; Orndorff PE; Kawula TH; Department of Microbiology and Immunology, University of North; Carolina School of Medicine, Chapel Hill, North Carolina 27599,; USA.; Haemophilus ducreyi causes chancroid, a sexually transmitted cutaneous genital ulcer disease associated with increased heterosexual transmission of human immunodeficiency virus. H. ducreyi expresses a periplasmic copper-zinc superoxide dismutase (Cu, Zn SOD) that protects the bacterium from killing by exogenous supero
Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.: Infect Immun. 1999 Oct;67(10):5372-8. Unique Identifier : AIDSLINE MED/99426837; Brady MT; O'Neill SM; Dalton JP; Mills KH; Infection and Immunity Group, Department of Biology, National; University of Ireland, Maynooth, County Kildare, Ireland.; Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell vaccine (Pw) induces a potent Th1 response, which confers a high level of protection against bacter
Expression of Chlamydia psittaci- and human immunodeficiency virus-derived antigens on the cell surface of Lactobacillus fermentum BR11 as fusions to bspA.: Infect Immun. 1999 Oct;67(10):5486-9. Unique Identifier : AIDSLINE MED/99426854; Turner MS; Giffard PM; Centre for Molecular Biotechnology, School of Life Sciences,; Queensland University of Technology, Brisbane, Queensland 4001,; Australia.; The basic surface protein, BspA, has been used as a fusion partner to direct peptide antigens from the human immunodeficiency virus gp41 protein and the Chlamydia psittaci OmpA protein to the cell surface of Lactobacillus fermentum BR11. BspA has potential utility in the construction of live vaccines and diagnostic re
Beta-estradiol-induced decrease in IL-12 and TNF-alpha expression suppresses macrophage functions in the course of Listeria monocytogenes infection in mice.: Int J Immunopharmacol. 1999 Aug;21(8):481-97. Unique Identifier : AIDSLINE MED/99385720; Salem ML; Matsuzaki G; Madkour GA; Nomoto K; Department of Immunology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan.; Mice treated with a contraceptive dose of beta-estradiol (E2) demonstrated changes in their macrophage (Mphi) number and functions. While E2 increased and decreased the Mphi number in PBMC and PEC respectively, it enhanced the in vitro phagocytosis of FITC-labeled beads by both cells. E2 treatment also enhanced the ph
The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass.: Int J Immunopharmacol. 1999 Aug;21(8):531-40. Unique Identifier : AIDSLINE MED/99385724; Hamano K; Gohra H; Katoh T; Fujimura Y; Zempo N; Esato K; First Department of Surgery, Yamaguchi University School of; Medicine, Ube, Japan.; The aim of this study was to determine whether the preoperative administration of lentinan, which is used clinically to activate T cell function in cancer patients, prevents the impairment of lymphocyte function after cardiopulmonary bypass (CPB). A total of 25 adults undergoing coronary artery bypass grafting were en
Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi.: Int J Epidemiol. 1999 Aug;28(4):769-75. Unique Identifier : AIDSLINE MED/99408586; Ioannidis JP; Taha TE; Kumwenda N; Broadhead R; Mtimavalye L; Miotti P; Yellin F; Contopoulos-Ioannidis DG; Biggar RJ; HIV Research Branch, Division of AIDS, National Institute of; Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.; jioannid@otenet.gr; BACKGROUND: Large simple trials which aim to study therapeutic interventions and epidemiological associations of human immunodeficiency virus (HIV) infection, including perinatal transmission, in Africa may have substantial rates of loss to follow-up. A better understanding of the characteristics and the impact of wom
Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses.: Hum Immunol. 1999 Jul;60(7):533-61. Unique Identifier : AIDSLINE MED/99353314; Lederman S; Suciu-Foca N; Department of Medicine and Pathology, Columbia University, New; York, NY 10032, USA. sl11@columbia.edu; An individual s set of polymorphic HLA class II and I molecules is known to select the T cell repertoire in the thymus and to present processed antigenic peptides (pAg) to mature peripheral CD4+ T helper (Th) and CD8+ T cytotoxic (Th) cells in the periphery. This review highlights new studies which address how antigen
Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells.: Hum Immunol. 1999 Jul;60(7):568-74. Unique Identifier : AIDSLINE MED/99353316; Liu Z; Tugulea S; Cortesini R; Lederman S; Suciu-Foca N; Department of Pathology, College of Physicians & Surgeons of; Columbia University, New York, NY 10032, USA.; Understanding the mechanism which underlies the induction of immunologic tolerance is crucial to the development of strategies for treatment of autoimmune diseases and allograft rejection. Although the concept that T suppressor cells (Ts) downregulate the immune response has long been accepted, the existence of a dist
A comparative evaluation of Etest and broth microdilution methods for fluconazole and itraconazole susceptibility testing of Candida spp.: J Antimicrob Chemother. 1999 Apr;43(4):477-81. Unique Identifier : AIDSLINE MED/99277878; Martin-Mazuelos E; Gutierrez MJ; Aller AI; Bernal S; Martinez MA; Montero O; Quindos G; Servicio de Microbiologia Clinica, Hospital Universitario de; Valme, Sevilla, Spain.; The Etest strip is a promising tool of broad application in clinical microbiology. The method provides MIC readings and is easier to perform than broth microdilution. We carried out a study to compare the MICs of fluconazole and itraconazole obtained by the Etest with those obtained by broth microdilution, performed a
Dr. Linda McGhee. Fayetteville physician first in her field.: J Ark Med Soc. 1999 Sep;96(4):127-8. Unique Identifier : AIDSLINE MED/99430163; May P
Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1.: J Cell Sci. 1999 Jul;112 ( Pt 14):2369-80. Unique Identifier : AIDSLINE MED/99310808; Rosorius O; Reichart B; Kratzer F; Heger P; Dabauvalle MC; Hauber J; Institute for Clinical and Molecular Virology, University; Erlangen-Nurnberg, Schlossgarten 4, D-91054 Erlangen, Germany.; Eukaryotic initiation factor 5A (eIF-5A) is the only cellular protein known to contain the unusual amino acid hypusine. The exact in vivo function of eIF-5A, however, is to date unknown. The finding that eIF-5A is an essential cofactor of the human immunodeficiency virus type 1 (HIV-1) Rev RNA transport factor suggest
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy [see comments]: J Clin Invest. 1999 Sep;104(6):R13-8. Unique Identifier : AIDSLINE MED/99423696; Ortiz GM; Nixon DF; Trkola A; Binley J; Jin X; Bonhoeffer S; Kuebler PJ; Donahoe SM; Demoitie MA; Kakimoto WM; Ketas T; Clas B; Heymann JJ; Zhang L; Cao Y; Hurley A; Moore JP; Ho DD; Markowitz M; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex drug regimens can prove problematic, and subjects may temporarily discontinue HAART for variable periods. We studied 6 HIV
The challenge of immune control of immunodeficiency virus [comment]: J Clin Invest. 1999 Sep;104(6):677-8. Unique Identifier : AIDSLINE MED/99423680; Richman D
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.: J Clin Invest. 1999 Sep;104(6):777-85. Unique Identifier : AIDSLINE MED/99423691; Chiaramonte MG; Donaldson DD; Cheever AW; Wynn TA; Schistosomiasis Immunology and Pathology Unit, Laboratory of; Parasitic Diseases, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; In schistosomiasis, chronic parasite egg-induced granuloma formation can lead to tissue destruction and fibrosis, which causes much of the morbidity and mortality associated with this disease. Here we show the importance of IL-13 in the pathogenesis of schistosomiasis, and demonstrate, perhaps for the first time, the
Single-dose pharmacokinetics of valganciclovir in HIV- and CMV-seropositive subjects.: J Clin Pharmacol. 1999 Aug;39(8):800-4. Unique Identifier : AIDSLINE MED/99363075; Jung D; Dorr A; Roche Global Development, Palo Alto, California, USA.; As a result of the low oral bioavailability of ganciclovir, a prodrug was developed to improve the bioavailability of ganciclovir. This study was designed to investigate the fasting, single-dose pharmacokinetics as well as the absolute and relative bioavailability of a valine ester prodrug of ganciclovir, valganciclov
The effect of azithromycin on the pharmacokinetics of indinavir.: J Clin Pharmacol. 1999 Aug;39(8):842-6. Unique Identifier : AIDSLINE MED/99363081; Foulds G; LaBoy-Goral L; Wei GC; Apseloff G; Department of Clinical Pharmacology, Pfizer Central Research,; Groton, Connecticut 06340, USA.; This study was performed to examine the effect of the coadministration of azithromycin on the pharmacokinetics of the protease inhibitor indinavir ( Crixivan ). In an open-label, parall
Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction [editorial]: J Clin Psychopharmacol. 1999 Aug;19(4):293-6. Unique Identifier : AIDSLINE MED/99367066; Greenblatt DJ; von Moltke LL; Daily JP; Harmatz JS; Shader RI
A descriptive analysis of students seeking HIV antibody testing at a university health service [see comments]: Unique Identifier : AIDSLINE MED/99414817; Anastasi MC; Sawyer RG; Pinciaro PJ; Department of Health Education at the University of Maryland,; College Park, USA.; The authors describe 255 students who voluntarily sought human immunodeficiency (HIV) antibody testing at a university health center. Fifty-nine percent of the students were women, their average age was 22.6 years, and they had low reported rates of unintended pregnancy and sexually transmitted diseases (STDs). Nearly
The development of CD4+ T effector cells during the type 2 immune response.: Immunol Res. 1999;20(1):55-65. Unique Identifier : AIDSLINE MED/99396059; Gause WC; Ekkens M; Nguyen D; Mitro V; Liu Q; Finkelman FD; Greenwald RJ; Urban JF; Department of Microbiology and Immunology, Uniformed Services; University of the Health Sciences, Bethesda, MD 20814, USA.; wgause@usuhs.mil; Multiple pathways may be involved in the development of interleukin 4 (IL-4) producing T helper (Th) cells and the associated type 2 immune response. Increasing evidence suggests that the strength of signals delivered to the T cell may favor the development of the type 2 response. In contrast, antigen-presenting cell-
Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans.: Immunol Res. 1999;20(1):67-78. Unique Identifier : AIDSLINE MED/99396060; Bagenstose LM; Salgame P; Monestier M; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; Human exposure to certain compounds or therapeutic drugs can result in the development of an autoimmune syndrome. Mercury (Hg) induced autoimmunity is one of the few animal models in which administration of a chemical induces a specific loss of tolerance to self-antigens. After receiving subtoxic doses of Hg or other
Association between condom use and HIV infection: a randomised study of self reported condom use measures.: J Epidemiol Community Health. 1999 Jul;53(7):417-22. Unique Identifier : AIDSLINE MED/99422403; Weir SS; Roddy RE; Zekeng L; Ryan KA; Family Health International, Durham, NC 27709, USA.; STUDY OBJECTIVE: To compare the association between different measures of condom use and prevalent HIV infection. DESIGN: Randomised cross sectional study to assess association between HIV infection and different measures of self reported condom use. Female sex workers were randomised to one of five different face to
Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes [comment]: Unique Identifier : AIDSLINE MED/99406768; Wang JM; Oppenheim JJ; Laboratory of Molecular Immunoregulation, Division of Basic; Sciences, National Cancer Institute-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702-1201, USA.; wangji@mail.ncifcrf.gov
The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains [see comments]: J Exp Med. 1999 Sep 6;190(5):597-605. Unique Identifier : AIDSLINE MED/99406769; Alfano M; Schmidtmayerova H; Amella CA; Pushkarsky T; Bukrinsky M; Picower Institute for Medical Research, Manhasset, New York; 11030, USA.; Infection of target cells by HIV-1 requires initial binding interactions between the viral envelope glycoprotein gp120, the cell surface protein CD4, and one of the members of the seven-transmembrane G protein-coupled chemokine receptor family. Most primary isolates (R5 strains) use chemokine receptor CCR5, but some p
Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice.: J Exp Med. 1999 Sep 6;190(5):607-15. Unique Identifier : AIDSLINE MED/99406770; Iijima H; Takahashi I; Kishi D; Kim JK; Kawano S; Hori M; Kiyono H; Department of Mucosal Immunology, Research Institute for; Microbial Diseases, Osaka University, Japan.; T cell receptor alpha chain-deficient (TCR-alpha(-/-)) mice are known to spontaneously develop inflammatory bowel disease (IBD). The colitis that develops in these mice is associated with increased numbers of T helper cell (Th)2-type CD4(+)TCR-betabeta (CD4(+)betabeta) T cells producing predominantly interleukin (IL)-
Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo.: J Exp Med. 1999 Sep 6;190(5):617-27. Unique Identifier : AIDSLINE MED/99406771; Nishimura T; Iwakabe K; Sekimoto M; Ohmi Y; Yahata T; Nakui M; Sato T; Habu S; Tashiro H; Sato M; Ohta A; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Tokai University School of; Medicine, Isehara, Japan.; The role of T helper type 1 (Th1) and Th2 cells in tumor immunity was investigated using Th cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice. Although Th1 cells exhibited stronger cytotoxicity than Th2 cells, both cell types completely eradicated tumors when transferred into mice bearing A20
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.: J Exp Med. 1999 Sep 6;190(5):705-15. Unique Identifier : AIDSLINE MED/99406778; Pittet MJ; Valmori D; Dunbar PR; Speiser DE; Lienard D; Lejeune F; Fleischhauer K; Cerundolo V; Cerottini JC; Romero P; Division of Clinical Onco-Immunology, Ludwig Institute for Cancer; Research, Lausanne Branch, Centre Hospitalier Universitaire; Vaudois, Switzerland.; Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specific cytolytic T lymphocytes (CTLs). In this paper, we enumerated and c
Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy.: J Exp Med. 1999 Sep 6;190(5):725-32. Unique Identifier : AIDSLINE MED/99406780; Zhang L; Lewin SR; Markowitz M; Lin HH; Skulsky E; Karanicolas R; He Y; Jin X; Tuttleton S; Vesanen M; Spiegel H; Kost R; van Lunzen J; Stellbrink HJ; Wolinsky S; Borkowsky W; Palumbo P; Kostrikis LG; Ho DD; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed alpha1 circle) of T cell receptor rearrangement. By studying 532 normal individuals, we found that alpha1 cir
Steatosis and intrahepatic hepatitis C virus in chronic hepatitis.: Unique Identifier : AIDSLINE MED/99389789; Fujie H; Yotsuyanagi H; Moriya K; Shintani Y; Tsutsumi T; Takayama T; Makuuchi M; Matsuura Y; Miyamura T; Kimura S; Koike K; Hepatic steatosis has been reported as one of the characteristics which discriminates hepatitis C from other forms of hepatitis, besides lymphoid follicles and bile duct damage. However, it is unclear whether or not the presence of hepatitis C virus (HCV) itself is associated with the development of steatosis. The pos
Comparative studies on neutralisation of primary HIV-1 isolates by human sera and rabbit anti-V3 peptide sera.: J Med Virol. 1999 Oct;59(2):169-79. Unique Identifier : AIDSLINE MED/99389794; Lawoko AL; Johansson B; Hjalmarsson S; Christensson B; Ljungberg B; Al-Khalili L; Sjolund M; Pipkorn R; Fenyo EM; Blomberg J; Section of Virology, Department of Medical Microbiology, Lund; University, Lund, Sweden. alex.lawoko@alinks.se; IgG binding to V3 peptides and serum neutralising responses were studied in four HIV-1 infected individuals with progressive disease over a period of 31-70 months. The 18-20 mer peptides comprised residues 299-317 (numbering of HIV1 MN) in the N-terminal half of the V3 loop of the envelope glycoprotein gp120 and were
Sequence requirements for incorporation of human immunodeficiency virus gag-beta-galactosidase fusion proteins into virus-like particles.: J Med Virol. 1999 Oct;59(2):180-8. Unique Identifier : AIDSLINE MED/99389795; Wang CT; Lai HY; Yang CC; Institute of Clinical Medicine, National Yang-Ming University; School of Medicine, and Department of Medical Research and; Education, Veterans General Hospital-Taipei, Taiwan, Republic of; China. ctwang@vghtpe.gov.tw; The incorporation of human immunodeficiency virus type 1 (HIV-1) Gag-beta-galactosidase (Gag-beta-gal; GBG) fusion proteins into HIV virus-like particles in the presence of HIV Gag proteins was studied. HIV Gag-beta-gal fusion constructs were cotransfected individually into COS7 cells with or without an HIV Gag protei
Human immunodeficiency viruses type 1 subtypes circulating in Sspain.: J Med Virol. 1999 Oct;59(2):189-93. Unique Identifier : AIDSLINE MED/99389796; Holguin A; Rodes B; Dietrich U; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.; Genetic subtypes of Human immunodeficiency viruses type 1 (HIV-1) were investigated in 101 HIV-1-infected individuals living in Spain from 1993 to 1998. Samples selected randomly from the HIV clinic population included 29 Spanish native born subjects (28.7%) and 72 foreigners (71.3%
Nucleotide sequence analysis of human T-cell lymphotropic virus type I pX and LTR regions from patients with sicca syndrome.: J Med Virol. 1999 Oct;59(2):245-55. Unique Identifier : AIDSLINE MED/99389806; Beby-Defaux A; Frugier F; Bourgoin A; Moynet D; Hajjar C; Sainte-Foie S; Guillemain B; Agius G; Laboratoire de Microbiologie B, EA 1720 Interactions Agents; Infectieux-Hotes, Centre Hospitalier Universitaire, Poitiers,; France.; Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia (ATL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). Other inflammatory disorders may occur in HTLV-I-infected patients, such as sicca syndrome resembling Sjogren s syndrome. The sicca syndrome may be the
Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.: Unique Identifier : AIDSLINE MED/99429287; Haughey NJ; Holden CP; Nath A; Geiger JD; Department of Pharmacology and Therapeutics, University of; Manitoba Faculty of Medicine, Winnipeg, Canada.; HIV-1 infection commonly leads to neuronal cell death and a debilitating syndrome known as AIDS-related dementia complex. The HIV-1 protein Tat is neurotoxic, and because cell survival is affected by the intracellular calcium concentration ([Ca2+]i), we determined mechanisms by whi
Influence of comorbidity and severity on the clinical outcome of bacteremic pneumococcal pneumonia treated with beta-lactam monotherapy.: J Chemother. 1999 Aug;11(4):266-72. Unique Identifier : AIDSLINE MED/99392797; Garau J; Aguilar L; Rodriguez-Creixems M; Dal-re R; Perez-Trallero E; Rodriguez M; Bouza E; Department of Medicine, Hospital Mutua de Terrassa, Barcelona,; Spain.; The influence of the severity of pneumonia and comorbidity factors, as predictors of clinical outcome, was assessed in patients with microbiologically documented pneumococcal bacteremic pneumonia treated with penicillin or third generation cephalosporin monotherapy in a 5-year retrospective study. Among 288 patients a
Oropharyngeal samples for genotyping and monitoring response to treatment in AIDS patients with Pneumocystis carinii pneumonia.: J Med Microbiol. 1999 Oct;48(10):897-905. Unique Identifier : AIDSLINE MED/99438984; Tsolaki AG; Miller RF; Wakefield AE; Department of Paediatrics, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford.; A nested PCR, amplifying a portion of the gene encoding the mitochondrial large subunit ribosomal RNA (mt LSU rRNA) of Pneumocystis carinii sp. f. hominis was applied to oropharyngeal samples obtained on repeated occasions from 12 HIV-infected patients with P. carinii pneumonia (PCP) to monitor response to anti-P. car
Functional antibody response to human cytomegalovirus in immunocompetent and HIV-1 infected individuals with antibodies that inhibit virus penetration into cells and intercellular transmission of viral infection.: Unique Identifier : AIDSLINE MED/99438990; Alberola J; Tamarit A; Navarro D; Antibodies mediating post-attachment virus neutralisation (PN), inhibition of human cytomegalovirus (HCMV)-induced cell fusion in the glioblastoma cell line U373 (IF) and global neutralising activity (NA) were quantified in sera from healthy immunocompetent individuals, asymptomati
Motor skill impairment in SIV-infected rhesus macaques with rapidly and slowly progressing disease.: J Med Primatol. 1999 Jun;28(3):105-17. Unique Identifier : AIDSLINE MED/99402096; Marcario JK; Raymond LA; McKiernan BJ; Foresman LL; Joag SV; Raghavan R; Narayan O; Cheney PD; Department of Molecular and Integrative Physiology, University of; Kansas Medical Center, Kansas City 66160, USA.; A number of studies have shown that simian immunodeficiency virus (SIV) infection in rhesus macaques parallels many aspects of HIV disease in humans. The purpose of this study was to further characterize the rhesus macaque infected with neurovirulent SIV as a model of neuroAIDS. Using a motor skill task, our objective
Neutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm).: J Med Primatol. 1999 Jun;28(3):97-104. Unique Identifier : AIDSLINE MED/99402095; Gicheru MM; Otsyula M; Spearman P; Graham BS; Miller CJ; Robinson HL; Haigwood NL; Montefiori DC; Institute of Primate Research, National Museums of Kenya,; Nairobi.; This study assessed the magnitude and cross-reactivity of the neutralizing antibody response generated by natural SIV infection in wild-caught African green monkeys. Neutralizing antibodies of variable potency, sometimes exceeding a titer of 1:1,000, were detected in 20 of 20 SIV-seropositive African green monkeys in
Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.: J Virol. 1999 Oct;73(10):7965-71. Unique Identifier : AIDSLINE MED/99412308; Aubagnac S; Brahic M; Bureau JF; Unite des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724; Paris Cedex 15, France.; Theiler s virus causes a persistent infection and a demyelinating disease of mice which is a model for multiple sclerosis. Susceptibility to viral persistence maps to several loci, including the interferon gamma locus. Inactivating the gene coding for the interferon gamma receptor makes 129/Sv mice susceptible to pers
CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir.: J Virol. 1999 Oct;73(10):7972-80. Unique Identifier : AIDSLINE MED/99412309; Moir S; Lapointe R; Malaspina A; Ostrowski M; Cole CE; Chun TW; Adelsberger J; Baseler M; Hwu P; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Human immunodeficiency virus type 1 (HIV-1) replicates primarily in lymphoid tissues where it has ready access to activated immune competent cells. We used one of the major pathways of immune activation, namely, CD40-CD40L interactions, to study the infectability of B lymphocytes isolated from peripheral blood mononuc
Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.: J Virol. 1999 Oct;73(10):7981-7. Unique Identifier : AIDSLINE MED/99412310; Tsukahara T; Kannagi M; Ohashi T; Kato H; Arai M; Nunez G; Iwanaga Y; Yamamoto N; Ohtani K; Nakamura M; Fujii M; Department of Immunotherapeutics, Medical Research Division,; Tokyo Medical and Dental University, Tokyo 113, Japan.; Human T-cell leukemia virus type 1 (HTLV-1) Tax is thought to play a pivotal role in immortalization of T cells. We have recently shown that the expression of Tax protected the mouse T-cell line CTLL-2 against apoptosis induced by interleukin-2 ( IL-2 ) deprivation and c
The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule.: J Virol. 1999 Oct;73(10):8035-9. Unique Identifier : AIDSLINE MED/99412317; Furchner M; Erickson AL; Allen T; Watkins DI; Sette A; Johnson PR; Walker CM; Children's Research Institute, Children's Hospital, Inc.,; Department of Pediatrics, College of Medicine and Public Health,; The Ohio State University, Columbus, Ohio, USA.; Cytotoxic T lymphocyte (CTL) responses against the simian immunodeficiency virus (SIV) envelope and Gag proteins were monitored in a Mamu-A*01-positive rhesus macaque infected with SIVsmE660. Peripheral blood mononuclear cells (PBMC) cultured with synthetic peptides spanning the entire gp160 and Gag coding region reco
Separate assembly and transport domains within the Gag precursor of Mason-Pfizer monkey virus.: J Virol. 1999 Oct;73(10):8073-82. Unique Identifier : AIDSLINE MED/99412321; Sakalian M; Hunter E; Department of Microbiology, The University of Alabama at; Birmingham, Birmingham, Alabama 35294, USA.; Mason- Pfizer monkey virus (M-PMV), the prototypical type D retrovirus, assembles immature capsids within the cytoplasm of the cell prior to plasma membrane interaction. Several mutants of M-PMV Gag have been described which display altered transport, assembly, or both. In
Efficiency and fidelity of full-site integration reactions using recombinant simian immunodeficiency virus integrase.: J Virol. 1999 Oct;73(10):8104-11. Unique Identifier : AIDSLINE MED/99412324; Goodarzi G; Pursley M; Felock P; Witmer M; Hazuda D; Brackmann K; Grandgenett D; Institute for Molecular Virology, St. Louis University Health; Sciences Center, St. Louis, Missouri 63110, USA.; Full-site integration by recombinant wild-type and mutant simian immunodeficiency virus (SIV) integrase (IN) was investigated with linear retrovirus-like DNA (469 bp) as a donor substrate and circular DNA (2,867 bp) as a target substrate. Under optimized conditions, recombinant SIV IN produced donor-target products co
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs.: J Virol. 1999 Oct;73(10):8112-9. Unique Identifier : AIDSLINE MED/99412325; Kusuhara K; Anderson M; Pettiford SM; Green PL; Department of Microbiology and Immunology, Vanderbilt University; School of Medicine, Nashville, Tennessee 37232-2363, USA.; The human T-cell leukemia virus (HTLV) Rex protein is essential for efficient expression of the viral structural and enzymatic gene products. In this study, we assessed the role of the HTLV-2 rex gene in viral RNA expression and Gag protein production. Following transfection of human JM4 T cells with wild-type and rex
Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication.: J Virol. 1999 Oct;73(10):8120-6. Unique Identifier : AIDSLINE MED/99412326; Kolchinsky P; Mirzabekov T; Farzan M; Kiprilov E; Cayabyab M; Mooney LJ; Choe H; Sodroski J; Department of Cancer, Dana-Farber Cancer Institute, Children's; Hospital, Harvard Medical School, Boston, Massachusetts 02115,; USA.; The gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and chemokine receptors on the target cell. Primary, clinical HIV-1 isolates require interaction with CD4 to allow gp120 to bind the CCR5 chemokine receptor efficiently. We adapted a prim
Intracellular interaction of simian immunodeficiency virus Gag and Env proteins.: J Virol. 1999 Oct;73(10):8138-44. Unique Identifier : AIDSLINE MED/99412328; Vincent MJ; Melsen LR; Martin AS; Compans RW; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.; In polarized epithelial cells, the assembly and release of human immunodeficiency virus type 1 (HIV-1) occur at the basolateral side of the plasma membrane, and the site of assembly is determined by the site of expression of the Env protein. In order to investigate whether the expression of the Env proteins exclusivel
Bovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model.: J Virol. 1999 Oct;73(10):8160-6. Unique Identifier : AIDSLINE MED/99412331; Kucerova L; Altanerova V; Altaner C; Boris-Lawrie K; Cancer Research Institute, Slovak Academy of Sciences, SK-833 91; Bratislava, Slovakia.; Infection with a replication-competent bovine leukemia virus structural gene vector (BLV SGV) is an innovative vaccination approach to prevent disease by complex retroviruses. Previously we developed BLV SGV that constitutively expresses BLV gag, pol, and env and related cis-acting sequences but lacks tax, rex, RIII,
Search for the mechanism of genetic variation in the pro gene of human immunodeficiency virus.: J Virol. 1999 Oct;73(10):8167-78. Unique Identifier : AIDSLINE MED/99412332; Rouzine IM; Coffin JM; Department of Molecular Biology and Microbiology, School of; Medicine, Tufts University, Boston, Massachusetts 02111, USA.; irouzine@emerald.tufts.edu; To study the mechanism of evolution of the human immunodeficiency virus (HIV) protease gene (pro), we analyzed a database of 213 pro sequences isolated from 11 HIV type 1-infected patients who had not been treated with protease inhibitors . Variation in pro is restri
Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited.: J Virol. 1999 Oct;73(10):8179-84. Unique Identifier : AIDSLINE MED/99412333; Kern F; Surel IP; Faulhaber N; Frommel C; Schneider-Mergener J; Schonemann C; Reinke P; Volk HD; Institut fur Medizinische Immunologie, Medizinische Fakultat; der Humboldt-Universitat zu Berlin (Charite), 10098 Berlin,; Germany. florian.kern@charite.de; Cell-mediated immunity plays an essential role in the control of infection with the human cytomegalovirus (HCMV). However, only a few CD8(+)-T-cell epitopes are known, with the majority being contained in the pp65 phosphoprotein, which is believed to dominate the CD8(+)-T-cell resp
Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques.: J Virol. 1999 Oct;73(10):8201-15. Unique Identifier : AIDSLINE MED/99412336; Polacino PS; Stallard V; Klaniecki JE; Pennathur S; Montefiori DC; Langlois AJ; Richardson BA; Morton WR; Benveniste RE; Hu SL; Regional Primate Research Center, University of Washington,; Seattle, USA.; We previously showed that envelope (gp160)-based vaccines, used in a live recombinant virus priming and subunit protein boosting regimen, protected macaques against intravenous and intrarectal challenges with the homologous simian immunodeficiency virus SIVmne clone E11S. However, the breadth of protection appears to
Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization.: J Virol. 1999 Oct;73(10):8216-26. Unique Identifier : AIDSLINE MED/99412337; Hung CS; Vander Heyden N; Ratner L; Departments of Medicine, Pathology, and Molecular Microbiology,; Washington University School of Medicine, St. Louis, Missouri; 63110, USA.; Human immunodeficiency virus type 1 (HIV-1) infection of CD4(+) lymphocytes and macrophages involves interaction of the surface subunit of the envelope protein (gp120) with coreceptors. Isolates have been found with specific tropism for macrophages and/or T-cell lines, through the utilization of chemokine receptor CCR
Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia.: Unique Identifier : AIDSLINE MED/99412341; Zheng J; Ghorpade A; Niemann D; Cotter RL; Thylin MR; Epstein L; Swartz JM; Shepard RB; Liu X; Nukuna A; Gendelman HE; Chemokine receptors pivotal for human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes and macrophages (CCR3, CCR5, and CXCR4) are expressed on neural cells (microglia, astrocytes, and/or neurons). It is these cells which are damaged during progressive HIV-1 infection of the central nervous system. We th
Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6.: J Virol. 1999 Oct;73(10):8268-78. Unique Identifier : AIDSLINE MED/99412342; Wan X; Wang H; Nicholas J; Molecular Virology Laboratories, Department of Oncology, Johns; Hopkins University School of Medicine, Baltimore, Maryland 21231,; USA.; Human herpesvirus 8 (HHV-8) has been associated with classical, endemic (African), and AIDS-related Kaposi s sarcoma (KS), body cavity-based primary effusion lymphomas, and multicentric Castleman s disease (MCD). HHV-8 encodes a functional homologue of interleukin-6 (IL-6), a cytokine that promotes the growth of KS an
Diminished rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes.: J Virol. 1999 Oct;73(10):8279-89. Unique Identifier : AIDSLINE MED/99412343; Ludwig E; Silberstein FC; van Empel J; Erfle V; Neumann M; Brack-Werner R; Institute of Molecular Virology, GSF-National Research Center for; Environment and Health, D-85764 Neuherberg, Germany.; Astrocytes are target cells for human immunodeficiency virus type 1 (HIV-1) in the central nervous system with attenuated virus replication in vivo and in vitro. In infected astrocytes, viral gene expression is restricted mainly to nonstructural (early) viral components like Nef, suggesting inhibition of Rev-dependent
trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant.: J Virol. 1999 Oct;73(10):8290-302. Unique Identifier : AIDSLINE MED/99412344; Chen SS; Lee SF; Chuang CK; Raj VS; Division of Infectious Diseases, Institute of Biomedical; Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.; schen@ibms.sinica.edu.tw; We previously reported that a human immunodeficiency virus type 1 (HIV-1) envelope (Env) mutant with the whole cytoplasmic domain deleted, denoted mutant TC, is able to dominantly interfere with wild-type (wt) virus infectivity. In the present study, the feasibility of developing a dominant negative mutant-based genet
Protection by live, attenuated simian immunodeficiency virus against heterologous challenge.: J Virol. 1999 Oct;73(10):8356-63. Unique Identifier : AIDSLINE MED/99412351; Wyand MS; Manson K; Montefiori DC; Lifson JD; Johnson RP; Desrosiers RC; Primedica, Worcester, Massachusetts 01608, USA.; We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Delta3, which is missing nef and vpr genes, to protect against challenge by heterologous strains SHIV89.6p and SIVsmE660. SHIV89.6p is a pathogenic, recombinant SIV in which the envelope gene has been replace
Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1.: J Virol. 1999 Oct;73(10):8364-70. Unique Identifier : AIDSLINE MED/99412352; Schonning K; Lund O; Lund OS; Hansen JE; Laboratory for Infectious Diseases 144, Hvidovre Hospital,; DK-2650 Hvidovre, Denmark. krs@dadlnet.dk; In order to study the stoichiometry of monoclonal antibody (MAb) neutralization of T-cell line-adapted human immunodeficiency virus type 1 (HIV-1) in antibody excess and under equilibrium conditions, we exploited the ability of HIV-1 to generate mixed oligomers when different env genes are coexpressed. By the coexpres
The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.: J Virol. 1999 Oct;73(10):8371-83. Unique Identifier : AIDSLINE MED/99412353; Kirchhoff F; Munch J; Carl S; Stolte N; Matz-Rensing K; Fuchs D; Haaft PT; Heeney JL; Swigut T; Skowronski J; Stahl-Hennig C; Institute for Clinical and Molecular Virology, University of; Erlangen-Nuernberg, 91054 Erlangen, Germany.; fkkirchh@viro.med.uni-erlangen.de; The nef gene of the pathogenic simian immunodeficiency virus (SIV) 239 clone was replaced with primary human immunodeficiency virus type 1 (HIV-1) nef alleles to investigate whether HIV-1 Nef can substitute for SIV Nef in vivo. Initially, two rhesus macaques were infected with the chimeric viruses (Nef-SHIVs). Most of
Regulation of bovine leukemia virus tax and pol mRNA levels by interleukin-2 and -10.: Unique Identifier : AIDSLINE MED/99412359; Pyeon D; Splitter GA; Recently, particular cytokines have been identified to affect progression of a variety of diseases and retrovirus infections.
Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.: J Virol. 1999 Oct;73(10):8448-56. Unique Identifier : AIDSLINE MED/99412362; Sharma PL; Crumpacker CS; Division of Infectious Disease, Beth Israel Deaconess Medical; Center, Boston, Massachusetts 02215, USA.; psharma@caregroup.harvard.edu; We previously showed that a didanosine-selected mutation in pNL4-3 background conferred a replication disadvantage on human immunodeficiency virus type 1, resulting in a loss of replication fitness. This work has been extended by showing that a recombinant virus with the HXBc2 backbone and reverse transcriptase (RT) f
Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein.: J Virol. 1999 Oct;73(10):8527-40. Unique Identifier : AIDSLINE MED/99412371; Burniston MT; Cimarelli A; Colgan J; Curtis SP; Luban J; Departments of Microbiology, Columbia University, College of; Physicians and Surgeons, New York, New York 10032, USA.; The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein directs the formation of virions from productively infected cells. Many gag mutations disrupt virion assembly, but little is known about the biochemical effects of many of these mutations. Protein-protein interactions among Gag monomers are believed to be
Inhibition of human immunodeficiency virus type 1 infectivity by the gp41 core: role of a conserved hydrophobic cavity in membrane fusion.: J Virol. 1999 Oct;73(10):8578-86. Unique Identifier : AIDSLINE MED/99412376; Ji H; Shu W; Burling FT; Jiang S; Lu M; Department of Biochemistry, Weill Medical College of Cornell; University, New York, New York 10021, USA.; The gp41 envelope protein of human immunodeficiency virus type 1 (HIV-1) contains an alpha-helical core structure responsible for mediating membrane fusion during viral entry. Recent studies suggest that a conserved hydrophobic cavity in the coiled coil of this core plays a distinctive structural role in maintaining t
Initial binding of murine leukemia virus particles to cells does not require specific Env-receptor interaction.: J Virol. 1999 Oct;73(10):8599-611. Unique Identifier : AIDSLINE MED/99412378; Pizzato M; Marlow SA; Blair ED; Takeuchi Y; Chester Beatty Laboratories, Institute of Cancer Research, London; SW3 6JB, United Kingdom.; The initial step of virus-cell interaction was studied by immunofluorescence microscopy. Single particles of murine leukemia virus (MLV) vectors and human immunodeficiency virus (HIV) were visualized by immunofluorescence. Fluorescent dots representing single virions could be localized by staining of capsid proteins (
Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj.: J Virol. 1999 Oct;73(10):8630-9. Unique Identifier : AIDSLINE MED/99412381; Hodge S; de Rosayro J; Glenn A; Ojukwu IC; Dewhurst S; McClure HM; Bischofberger N; Anderson DC; Klumpp SA; Novembre FJ; Departments of Microbiology and Immunology, University of; Rochester Medical Center, Rochester, New York, USA.; The fatal disease induced by SIVsmmPBj4 clinically resembles endotoxic shock, with the development of severe gastrointestinal disease. While the exact mechanism of disease induction has not been fully elucidated, aspects of virus biology suggest that immune activation contributes to pathogenesis. These biological char
Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: evidence for frequent in vivo recombination events in the evolution of regional populations.: J Virol. 1999 Oct;73(10):8720-31. Unique Identifier : AIDSLINE MED/99412391; Morris A; Marsden M; Halcrow K; Hughes ES; Brettle RP; Bell JE; Simmonds P; Department of Medical Microbiology, University of Edinburgh,; Edinburgh EH8 9AG, Edinburgh EH4 2XU, United Kingdom.; In addition to immunodeficiency, human immunodeficiency virus type 1 (HIV-1) can cause cognitive impairment and dementia through direct infection of the brain. To investigate the adaptive process and timing of HIV-1 entry into the central nervous system, we carried out an extensive
Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells.: J Virol. 1999 Oct;73(10):8813-6. Unique Identifier : AIDSLINE MED/99412401; Powell SK; Artlip M; Kaloss M; Brazinski S; Lyons R; McGarrity GJ; Otto E; Genetic Therapy, Inc., a Novartis Company, Gaithersburg, Maryland; 20878, USA. sharon.powell@pharma.novartis.com; Retroviral vectors for gene therapy are designed to minimize the occurrence of replication-competent retrovirus (RCR); nonetheless, it is possible that a vector-derived RCR could establish an infection in a patient. Since the efficacy of antiretroviral agents can be impacted by interactions between virus, host cell, a
Association of Nef with the human immunodeficiency virus type 1 core.: J Virol. 1999 Oct;73(10):8824-30. Unique Identifier : AIDSLINE MED/99412403; Kotov A; Zhou J; Flicker P; Aiken C; Department of Microbiology and Immunology, Vanderbilt University; School of Medicine, Nashville, Tennessee, USA.; Highly conserved among primate lentiviruses, the human immunodeficiency virus type 1 (HIV-1) Nef protein enhances viral infectivity by an unknown mechanism. Nef-defective virions are blocked at a stage of the HIV-1 life cycle between entry and reverse transcription, possibly virus uncoating. Nef is present in purified
Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.: J Virol. 1999 Oct;73(10):8831-6. Unique Identifier : AIDSLINE MED/99412404; Liu H; Wu X; Xiao H; Kappes JC; Departments of Medicine, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; Integrase (IN) is the only retroviral enzyme necessary for the integration of retroviral cDNA into the host cell s chromosomes. The structure and function of IN is highly conserved. The human immunodeficiency virus type 2 (HIV-2) IN has been shown to efficiently support 3 processing and strand transfer of HIV-1 DNA s
Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo.: J Virol. 1999 Oct;73(10):8873-9. Unique Identifier : AIDSLINE MED/99412411; Etemad-Moghadam B; Sun Y; Nicholson EK; Karlsson GB; Schenten D; Sodroski J; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Department of Pathology, Harvard Medical School,; Boston, Massachusetts 02115, USA.; In vivo passage of a simian-human immunodeficiency virus (SHIV-89.6) generated a virus, SHIV-89.6P, that exhibited increased resistance to some neutralizing antibodies (G. B. Karlsson et al., J. Exp. Med. 188:1159-1171, 1998). Here we examine the range of human immunodeficiency virus type 1 (HIV-1) neutralizing antibo
[B-cell, T-cell surface phenotypes and epitopes in autoimmune thyroid diseases]: Nippon Rinsho. 1999 Aug;57(8):1743-8. Unique Identifier : AIDSLINE MED/99412741; Nishiya K; Kaneda T; Hashimoto K; Second Department of Internal Medicine, Kochi Medical School.; Autoimmune thyroid diseases (AITD) are categorized as organ specific autoimmune diseases, including Graves disease (GD), Hashimoto s thyroiditis and idiopathic myxoedema. In this article, B-, T-cell surface phenotypes and epitopes in AITD were reviewed. It has been reported that the proportion and absolute number of
[AIDS and tuberculosis in the light of spreading drug abuse]: Klin Med (Mosk). 1999;77(2):7-12. Unique Identifier : AIDSLINE MED/99309551; Volkova KI; Kokosov AN
The influence of perceived responsibility and personality characteristics on the emotional and behavioral reactions to people with AIDS.: J Soc Psychol. 1999 Aug;139(4):487-95. Unique Identifier : AIDSLINE MED/99386213; Steins G; Weiner B; Department of Psychology, Universitat Bielefeld, Germany.; gsteins@hrz.uni-bielefeld.de; The present study examined the effect of a target s personality and responsibility for a misdeed on a perceiver s emotions and behavior by determining the variables impact on the perceiver s emotional reactions and willingness to help the target. A total of 134 Germans and 171 Americans were given information about t
Inverse association between BCG immunisation and intestinal nematode infestation among HIV-1-positive individuals in Uganda [letter]: Lancet. 1999 Sep 18;354(9183):1000-1. Unique Identifier : AIDSLINE MED/99429475; Elliott AM; Nakiyingi J; Quigley MA; French N; Gilks CF; Whitworth JA; Exposure to infections in infancy may induce a sustained bias in the immune response. In our study, previous BCG immunisation was associated with a reduced prevalence of intestinal nematode infection.
Indian government re-evaluates AIDS control [news]: Lancet. 1999 Sep 18;354(9183):1010. Unique Identifier : AIDSLINE MED/99429485; Sharma DC
WHO gives southeast Asia a health warning [news]: Lancet. 1999 Sep 18;354(9183):1010. Unique Identifier : AIDSLINE MED/99429486; Kumar S
Cysteine, glutathione (GSH) and zinc and copper ions together are effective, natural, intracellular inhibitors of (AIDS) viruses.: Med Hypotheses. 1999 Jun;52(6):529-38. Unique Identifier : AIDSLINE MED/99387590; Sprietsma JE; Sprietsma MBS, Bennekom, The Netherlands.; Sufficient essential nutrients such as methionine, cysteine, copper, selenium, zinc and vitamins C and E are indispensable for the maintenance of optimal (immune) cell functions. Parasitic organisms such as protozoa, fungi, bacteria and viruses also depend on these essential nutrients for their multiplication and func
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis hypothesis. A shift of homologous peptides pairs, central nervous system (CNS)/HTLF-1, HTLV-1/thymus, thymus/CNS, in a thymus-like CNS environment, underlies the pathogenesis of HAM/TSP.: Med Hypotheses. 1999 Jun;52(6):595-604. Unique Identifier : AIDSLINE MED/99387600; Plumelle Y; Department of Hematobiology, University Hospital, Fort de France,; Martinique, FWI. ffhemato@sasi.fr; Determinants shared by thymus, brain and HTLV-1 induce lymphocytic neurotropism and demyelinization in HAM/TSP, within the framework thymus-like brain environment. The disease evolves in two phases. The first phase of the disease would be dependent on CD4 T-lymphocytes specific for thymic autoantigens, reactivated by
[Intestinal lymphoma. A long diagnostic path (clinical conference)]: Med Klin. 1999 Jun 15;94(6):345-52. Unique Identifier : AIDSLINE MED/99349212; Raab N; Heller T; Kroger J; Freund M; Nizze H; Rolfs A; Liebe S; Lohr M; Abteilung fur Gastroenterologie, Klinik fur Innere Medizin,; Universitat Rostock.; CASE REPORT: We describe the case of a 43-year-old patient with a Burkitt lymphoma in the small intestine, who initially presented with abdominal discomfort, weight loss, constipation and neurological symptoms. DIAGNOSIS: In terms of differential diagnosis other inflammatory and tumorous diseases had to be considered.
Neurobehavioral effects of perinatal AZT exposure in Sprague-Dawley adult rats.: Neurotoxicol Teratol. 1999 Jul-Aug;21(4):359-63. Unique Identifier : AIDSLINE MED/99367091; Busidan Y; Dow-Edwards DL; Department of Physiology/Pharmacology, State University of New; York, Health Science Center, Brooklyn 11203, USA.; Since AZT (azidothymidine, zidovudine, ZDV) has become the standard of care for preventing human immunodeficiency virus transmission during pregnancy, we conducted a study to assess the possible long-term neurobehavioral effects of AZT, using a rat mo
Neurobehavioral effects of prenatal lamivudine (3TC) exposure in preweaning mice.: Neurotoxicol Teratol. 1999 Jul-Aug;21(4):365-73. Unique Identifier : AIDSLINE MED/99367092; Calamandrei G; Venerosi A; Branchi I; Valanzano A; Puopolo M; Alleva E; Comparative Psychology Section, Laboratorio di Fisiopatologia di; Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy.; gemma@iss.it; The present study provides a characterization of the behavioral changes induced in preweaning mice by prenatal exposure to lamivudine ( 3TC ), an antiviral drug recently entered in the clinical practice to treat HIV patients. Pregnant CD1 mice were give
Innocents abroad? The ethics of international research.: Minn Med. 1999 Jul;82(7):28-9. Unique Identifier : AIDSLINE MED/99360211; Kahn J; Mastroianni A; Center for Bioethics, University of Minnesota, USA.
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.: Mol Pharmacol. 1999 Oct;56(4):693-704. Unique Identifier : AIDSLINE MED/99426952; Saboulard D; Naesens L; Cahard D; Salgado A; Pathirana R; Velazquez S; McGuigan C; De Clercq E; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Leuven, Belgium.; The phosphoramidate triester prodrugs of anti-human HIV 2 , 3 -dideoxynucleoside analogs (ddN) represent a convenient approach to bypass the first phosphorylation to ddN 5 -monophosphate (ddNMP), resulting in an improved formation of ddN 5 -triphosphate and, hence, higher antiviral efficacy. Although phosphoramidate d
A 60 kD heat-shock protein-like molecule interacts with the HIV transmembrane glycoprotein gp41.: Mol Immunol. 1999 Jun;36(9):619-28. Unique Identifier : AIDSLINE MED/99428161; Speth C; Prohaszka Z; Mair M; Stockl G; Zhu X; Jobstl B; Fust G; Dierich MP; Institute for Hygiene and Ludwig Boltzmann-Institute for AIDS; Research, Innsbruck, Austria. cornelia.speth@uibk.ac.at; The heat-shock protein hsp60 is typically found in mitochondria, but, in smaller amounts, also in the cell cytoplasm and associated with the cell membrane. Since heat-shock proteins are known to interact with a variety of molecules and since purified HIV-1 particles were described to contain hsp60 molecules, we tested
Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment [see comments]: N Engl J Med. 1999 Oct 14;341(16):1174-9. Unique Identifier : AIDSLINE MED/99435541; van Rie A; Warren R; Richardson M; Victor TC; Gie RP; Enarson DA; Beyers N; van Helden PD; Department of Pediatrics and Child Health, University of; Stellenbosch, Tygerberg, South Africa.; BACKGROUND: For decades it has been assumed that postprimary tuberculosis is usually caused by reactivation of endogenous infection rather than by a new, exogenous infection. METHODS: We performed DNA fingerprinting with restriction-fragment-length polymorphism analysis on pairs of isolates of Mycobacterium tuberculos
Growth hormone therapy in adults and children.: N Engl J Med. 1999 Oct 14;341(16):1206-16. Unique Identifier : AIDSLINE MED/99435546; Vance ML; Mauras N; Department of Internal Medicine, University of Virginia Medical; Center, Charlottesville 22908, USA.
Effect of highly active antiretroviral therapy on thrombocytopenia in patients with HIV infection [letter]: N Engl J Med. 1999 Oct 14;341(16):1239-40. Unique Identifier : AIDSLINE MED/99435559; Arranz Caso JA; Sanchez Mingo C; Garcia Tena J
HHV-8 peripheral-blood viral load and the titer of antibodies against HHV-8 [letter]: N Engl J Med. 1999 Oct 14;341(16):1241-2. Unique Identifier : AIDSLINE MED/99435561; Campbell TB; Borok M; Gwanzura L
Exhaustive docking of molecular fragments with electrostatic solvation.: Proteins. 1999 Oct 1;37(1):88-105. Unique Identifier : AIDSLINE MED/99382454; Majeux N; Scarsi M; Apostolakis J; Ehrhardt C; Caflisch A; Department of Biochemistry, University of Zurich, Zurich,; Switzerland.; A new method is presented for docking molecular fragments to a rigid protein with evaluation of the binding energy. Polar fragments are docked with at least one hydrogen bond with the protein while apolar fragments are positioned in the hydrophobic pockets. The electrostatic contribution to the binding energy, which c
HIV evolutionary genetics [comment]: Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10559-61. Unique Identifier : AIDSLINE MED/99415893; Rodrigo AG
The molecular clock of HIV-1 unveiled through analysis of a known transmission history [see comments]: Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10752-7. Unique Identifier : AIDSLINE GENBANK/U68521; Leitner T; Albert J; Theoretical Biology and Biophysics, Group T-10, MS K710, Los; Alamos National Laboratory, Los Alamos, NM 87545, USA.; tkl@biochem.kth.se; Detailed knowledge about the rate and mode of the genetic variation is vital for understanding how HIV-1 induces disease and develops resistance as well as for studies on the molecular epidemiology and origin of the virus. To unveil the molecular clock of HIV-1 we analyzed a unique set of viruses from a known transmis
Linkage disequilibrium test implies a large effective population number for HIV in vivo [see comments]: Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10758-63. Unique Identifier : AIDSLINE MED/99415932; Rouzine IM; Coffin JM; Molecular and Microbiology Department, Tufts University, 136; Harrison Street, Boston MA 02111, USA. irouzine@emerald.tufts.edu; The effective size of the HIV population in vivo, although critically important for the prediction of appearance of drug-resistant variants, is currently unknown. To address this issue, we have developed a simple virus population model, within which the relative importance of stochastic factors and purifying selection
Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.: Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10842-7. Unique Identifier : AIDSLINE MED/99415946; Cohen SS; Li C; Ding L; Cao Y; Pardee AB; Shevach EM; Cohen DI; Dermatology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892, USA.; HIV infection is accompanied by an early immune dysfunction limiting host control of virus and likely contributing to difficulties in achieving a successful vaccine against HIV. We report here that the HIV Tat protein is strongly immunosuppressive, both immediately after immunization of mice with soluble protein (sTat
Knowledge of laws regulating issues related to HIV and AIDS: development of the HIV/AIDS and the law scale.: Psychol Rep. 1999 Jun;84(3 Pt 2):1345-53. Unique Identifier : AIDSLINE MED/99407338; Paniagua FA; Black SA; O'Boyle M; Jones P; Department of Psychiatry and Behavioral Sciences, University of; Texas Medical Branch, Galveston 77555-0425, USA.; fpaniagu@utmb.edu; 42 middle-aged and older adults, ranging in age from 51 to 85 years, completed 10 items dealing with the assessment of knowledge regarding laws regulating issues related to HIV and AIDS. Participants also completed 40 items involving knowledge of risks for HIV infection. The Cronbach coefficient alpha and test-retest
Reproductive health in Southeast Asia.: Public Health Rep. 1999 Jul-Aug;114(4):374-6. Unique Identifier : AIDSLINE MED/99429249; Bennett T; School of Public Health, UNC-Chapel Hill, NC 27599, USA.; trude_bennett@unc.edu
Pulmonary malignancies in the immunocompromised patient.: Respiration. 1999;66(4):289-309. Unique Identifier : AIDSLINE MED/99391900; Cadranel J; Naccache J; Wislez M; Mayaud C; Service de Pneumologie et de Reanimation Respiratoire, AP-HP; Hopital Tenon et Laboratoire de Biologie cellulaire et; d'Immunopathologie pulmonaire UPRES EA 1531, Universite Paris; VI, Paris, France.; Clinicians should be familiar with immunodeficiency-related malignancies, as their incidence is expected to increase further with the rise in the number and survival of immunocompromised patients. The most common malignancies affecting the lungs in those patients are Kaposi s sarcoma,
[Subcortical dementia in HTLV-I tropical spastic paraparesis. Study of 43 cases]: Rev Med Chil. 1999 Apr;127(4):444-50. Unique Identifier : AIDSLINE MED/99380909; Cartier L; Gormaz A; Departamento de Ciencias Neurologicas, Universidad de Chile.; BACKGROUND: Central nervous system damage associated to HTLV-I does not limit itself to the spinal cord, but also involves subcortical structures, producing cognitive impairment and behavioral changes which eventually could conform a new form of subcortical dementia . AIM: To study
View from the top of a biomedical empire [interview by Eliot Marshall]: Science. 1999 Sep 10;285(5434):1654-6. Unique Identifier : AIDSLINE MED/99444732; Varmus H
Ambitious clinical trial stirs debate [news]: Science. 1999 Sep 24;285(5436):2039; 2041-2. Unique Identifier : AIDSLINE MED/99446769; Cohen J
AIDS researchers blast NIH peer review plan [news]: Science. 1999 Sep 24;285(5436):2047. Unique Identifier : AIDSLINE MED/99446771; Marshall E
Opening the AIDS door [editorial; comment]: Southeast Asian J Trop Med Public Health. 1998 Sep;29(3):427-8. Unique Identifier : AIDSLINE MED/99364646; Kidson C
From research to practice: use of short course zidovudine to prevent mother-to-child HIV transmission in the context of routine health care in Northern Thailand [see comments]: Southeast Asian J Trop Med Public Health. 1998 Sep;29(3):429-42. Unique Identifier : AIDSLINE MED/99364647; Thaineua V; Sirinirund P; Tanbanjong A; Lallemant M; Soucat A; Lamboray JL; Office of the Inspector General, Ministry of Public Health,; Nonthaburi, Thailand.; Thailand has made remarkable progress in battling the HIVepidemic, as the decreases in HIV prevalence and changes in sexual behavior attest. Yet, in Phayao, a northern province severely affected by HIV, approximately 280 HIV-infected women, or 5% of all pregnant women, gave birth
Response to JE vaccine among HIV-infected children, Bangkok, Thailand.: Southeast Asian J Trop Med Public Health. 1998 Sep;29(3):443-50. Unique Identifier : AIDSLINE MED/99364648; Rojanasuphot S; Shaffer N; Chotpitayasunondh T; Phumiamorn S; Mock P; Chearskul S; Waranawat N; Yuentrakul P; Mastro TD; Tsai TF; National Institute of Health, Department of Medical Sciences,; Ministry of Public Health, Nonthaburi, Thailand.; Since 1990, Japanese encephalitis (JE) vaccine has been part of EPI in northern Thailand , where there is a high prevalence of JE and HIV infection. To evaluate the immunogenicity and safety of JE vaccine among HIV-infected children, we conducted a retrospective study of HIV-infec
The reference range of CD4+ and CD8+ T-lymphocytes in healthy non-infected infants born to HIV-1 seropositive mothers; a preliminary study at Siriraj Hospital.: Southeast Asian J Trop Med Public Health. 1998 Sep;29(3):453-63. Unique Identifier : AIDSLINE MED/99364650; Likanonsakul S; Wasi C; Thepthai C; Sutthent R; Louisirirotchanakul S; Chearskul S; Vanprapa N; Lebnark T; Bamrasnaradura Hospital, Department of Communicable Disease; Control, Ministry of Public Health, Nonthaburi, Thailand.; The results of CD4+, CD8+ T-lymphocyte values as percentage, number, and ratio were studied in infants aged 1 to 29 months. The 283 subsequent blood samples from 89 infants born to HIV-1 seropositive mothers were investigated. From 208 sequential samples of 70 healthy non-infected infants, the reference values of CD4+
[Health education and prevention of AIDS]: Srp Arh Celok Lek. 1999 May-Jun;127(5-6):196-201. Unique Identifier : AIDSLINE MED/99430215; Cucic V; Blegovic V; Vukovic D; Institut za socijalnu medicinu, statistiku i istrazivanja u; zdravstvu Medicinski fakultet, Beograd.
Recording sexual behavior: comparison of recall questionnaires with a coital diary.: Sex Transm Dis. 1999 Aug;26(7):374-80. Unique Identifier : AIDSLINE MED/99385811; Ramjee G; Weber AE; Morar NS; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Durban, South Africa.; OBJECTIVE: To compare sexual behavior data obtained using a weekly-recall questionnaire, a daily-recall questionnaire, and a coital diary. DESIGN: Cross-sectional survey of female sex workers from KwaZulu-Natal, South Africa between August and October 1998. METHODS: In this study,
Trichomonas vaginalis as a cause of urethritis in Malawian men [see comments]: Sex Transm Dis. 1999 Aug;26(7):381-7. Unique Identifier : AIDSLINE MED/99385812; Hobbs MM; Kazembe P; Reed AW; Miller WC; Nkata E; Zimba D; Daly CC; Chakraborty H; Cohen MS; Hoffman I; Department of Medicine, The University of North Carolina at; Chapel Hill, 27599, USA.; BACKGROUND AND OBJECTIVES: Trichomonas vaginalis is one of the most common sexually transmitted infections. In Malawi , rates of trichomoniasis in women are high. The prevalence of T. vaginalis infection in men is expected to be high but has not previously been documented. GOALS: We
Perceived monogamy and type of clinic as barriers to seeking care for suspected STD or HIV infection: results from a brief survey of low-income women attending Women, Infants, and Children (WIC) clinics in Missouri.: Sex Transm Dis. 1999 Aug;26(7):399-403. Unique Identifier : AIDSLINE MED/99385816; Crosby RA; Yarber WL; Meyerson B; Behavioral Interventions and Research Branch, Division of STD; Prevention, National Center for HIV, STD, and TB Prevention,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; BACKGROUND AND OBJECTIVES: Barriers to seeking care for sexually transmitted diseases (STDs) have not been assessed for low-income women. We sought to determine barriers to seeking care for STDs among women receiving Women, Infants, and Children (WIC) benefits in 21 Missouri counties. GOAL OF THIS STUDY: Provide infor
Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and HIV infection among drug users attending an STD/HIV prevention and needle-exchange program in Quebec City, Canada.: Sex Transm Dis. 1999 Aug;26(7):410-20. Unique Identifier : AIDSLINE MED/99385818; Poulin C; Alary M; Bernier F; Ringuet J; Joly JR; Unite de Recherche en Sante Publique, Centre Hospitalier; Universitaire de Quebec, Quebec, Canada.; OBJECTIVES: To determine the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and human immunodeficiency virus (HIV) infection among injection and noninjection drug users in Quebec City and to identify associated risk factors. STUDY DESIGN: Cross-sectional study of 738 drug users attending a sexually transm
The role of social work in HIV/AIDS clinical trials.: Soc Work Health Care. 1999;29(1):35-56. Unique Identifier : AIDSLINE MED/99409854; Williams JK; Boykin F; HIV Counseling Program, Clinical Center, National Institutes of; Health, Bethesda, MD 20892, USA. jwilliams@nih.gov; The social worker can facilitate screening, retention and patient adherence in HIV/AIDS clinical trials. This paper introduces the process and its key vocabulary, and uses three case studies to demonstrate how social workers can assist clients who may wish to participate in, or are already enrolled in a clinical trial
The role of the supervisor in training social workers treating HIV infected persons in a hospital.: Soc Work Health Care. 1999;29(1):57-74. Unique Identifier : AIDSLINE MED/99409855; Itzhaky H; Atzmon R; School of Social Work, Bar-Ilan University, Ramat Gan, Israel.; The role of social workers working with HIV infected persons in hospitals is complex and laden with sources of professional stress, including those related to the hospital framework and environment and personal stress related to patients, their families, and the workers themselves. The paper identifies these factors o
Effect of a single or repeated dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell subpopulations in the Long-Evans rat.: Toxicol Lett. 1999 Sep 20;109(1-2):97-104. Unique Identifier : AIDSLINE MED/99442193; Huang W; Koller LD; College of Veterinary Medicine, Oregon State University,; Corvallis, 97331, USA.; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in adverse effects on the immune system of experimental animals. The purpose of this study was to compare the effects of a single and repeated dosing of TCDD on splenic T-cell subpopulations in Long Evans rats 9 days post-exposure to TCDD. A single dose (25 m
Economic issues and antiretroviral therapy in developing countries.: Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):1-3. Unique Identifier : AIDSLINE MED/99422443; Forsythe S; Gilks C; HIV/AIDS Work Programme, Liverpool School of Tropical Medicine,; UK. forsythe@liv.ac.uk
Delayed-type hypersensitivity reactions to Onchocerca volvulus antigens in exposed and non-exposed African individuals.: Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):103-5. Unique Identifier : AIDSLINE MED/99422472; Burchard GD; Brattig NW; Kruppa TF; Horstmann RD; Tropical Medicine Section, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany. burchard@bni.uni-hamburg.de; Although considered of critical importance, the mode of helper T-lymphocyte function in Onchocerca volvulus infection is still unclear including the role of the Th1/Th2 dichotomy. We studied the delayed-type hypersensitivity (DTH) reaction, which is the classical Th1 response, to O. volvulus antigens in Africans expos
HIV-2 status in southern India.: Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):30-1. Unique Identifier : AIDSLINE MED/99422452; Kannangai R; Ramalingam S; Castillo RC; Babu PG; John TJ; Sridharan G; Schwartz DH; Department of Clinical Virology, Christian Medical College; Hospital, Vellore, India.
Tuberculosis in health care workers in Malawi.: Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):32-5. Unique Identifier : AIDSLINE MED/99422453; Harries AD; Nyirenda TE; Banerjee A; Boeree MJ; Salaniponi FM; National Tuberculosis Control Programme, Community Health Science; Unit, Lilongwe, Malawi.; Although sub-Saharan Africa has the highest rates of tuberculosis (TB) and human immunodeficiency virus (HIV) infection in the world, the rates of TB amongst its health care workers (HCWs) are poorly documented. We therefore conducted a country-wide investigation. All district/government and mission hospitals in
Antifungal susceptibilities of Cryptococcus neoformans in north-east Thailand.: Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):96-7. Unique Identifier : AIDSLINE MED/99422469; Wuthiekanun V; Howe PA; Simpson AJ; Smith MD; Walsh AL; Angus BJ; Rajchanuwong A; White NJ; Faculty of Tropical Medicine, Mahidol University, Bangkok,; Thailand.
Seroprevalence of hepatitis B and C, and human immunodeficiency type 1 viruses in a rural population from the Republic of Equatorial Guinea.: Trans R Soc Trop Med Hyg. 1999 May-Jun;93(3):250-2. Unique Identifier : AIDSLINE MED/99422419; Basaras M; Santamaria A; Sarsa M; Gutierrez E; de Olano Y; Cisterna R; Departamento de Microbiologia, Facultad de Medicina, Universidad; del Pais Vasco, Bilbao, Spain. oipbaibm@lg.ehu.es; The seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) markers was evaluated in a group of 2042 subjects from a rural area in the Republic of Equatorial Guinea , to obtain a better understanding of the transmission pat
Epidemiology of histoplasmosis in the French West Indies (Martinique).: Trans R Soc Trop Med Hyg. 1999 May-Jun;93(3):264-7. Unique Identifier : AIDSLINE MED/99422423; Garsaud P; Boisseau-Garsaud AM; Desbois N; Verneuil L; Cales-Quist D; Helenon R; Jouannelle A; Delord JM; Sobesky G; Panelatti G; Departement d'Information Medicale, Centre Hospitalier; Universitaire de Fort de France, Martinique, French West Indies.; garsaud@sasi.fr; The Caribbean islands are presumed to be an endemic zone for Histoplasma capsulatum infection, but no epidemiological studies have been done in this area. Our purpose was to report the epidemiology of histoplasmosis from 1991 to 1997 in the French West Indies (
HIV and tuberculosis in rural sub-Saharan Africa: a cohort study with two year follow-up.: Trans R Soc Trop Med Hyg. 1999 May-Jun;93(3):287-93. Unique Identifier : AIDSLINE MED/99422429; Kelly PM; Cumming RG; Kaldor JM; Department of Public Health and Community Medicine, University of; Sydney, NSW, Australia. paul.kelly@casrdh.health.nt.gov.au; The objective was to examine the effect of HIV seropositivity on outcomes in tuberculosis (TB) patients in a rural African setting, including rates of TB relapse, other morbid events and mortality. The study setting was a district level hospital in Mzuzu, Malawi . Adult TB patients
Lamivudine therapy of hepatitis B virus-related liver disease: cirrhosis, posttransplantation recurrence, and de novo infection.: Transplant Proc. 1999 Sep;31(6):2457-8. Unique Identifier : AIDSLINE MED/99430456; Barcena R; Dominguez-Antonaya M; Lopez-Sanroman A; Martinez-Turnes A; Urman J; del Campo S; Moreno N; Hospital Ramon y Cajal, Servicio Gastroenterologia, Madrid,; Spain.
Serum levels of xenoantibodies in different groups of patients awaiting transplantation.: Transplant Proc. 1999 Sep;31(6):2631-2. Unique Identifier : AIDSLINE MED/99430538; Ramos A; Escallada R; Echevarria S; Pastor JM; Ruiz JC; de Francisco AL; Cotorruelo JG; Fleitas MG; Arias M; Nephrology Unit, H.U. Marques de Valdecilla, Santander, Spain.
HIV-1 infection induces differentiation of immature neural cells through autocrine tumor necrosis factor and nitric oxide production.: Unique Identifier : AIDSLINE MED/99428756; Obregon E; Punzon C; Fernandez-Cruz E; Fresno M; Munoz-Fernandez MA; Immature neural cell lines could be productively infected by HIV-1. Interestingly, this infection was associated with a differentiation to a mature neuronal phenotype, characterized by the expression of mature neurofilaments and cell adhesion molecules, intercellular cell adhesion molecule-1, and vascular cell adhesio
Differential regulation of CC chemokine gene expression in human immunodeficiency virus-infected myeloid cells.: Virology. 1999 Sep 1;261(2):205-15. Unique Identifier : AIDSLINE MED/99428757; Genin P; Mamane Y; Kwon H; LePage C; Wainberg MA; Hiscott J; Lady Davis Institute for Medical Research, McGill University,; Montreal, H3T 1E2, Canada.; The importance of chemokine expression on HIV infection has been emphasized by the discovery that infection of CD4(+) T cells by M-tropic strains of HIV-1 is antagonized by the chemokines RANTES, MIP-1alpha, and MIP-1beta, which are natural ligands of CCR5, a major coreceptor for macrophagetropic (M-tropic) isolates o
Natural variation of equine infectious anemia virus Gag protein cytotoxic T lymphocyte epitopes.: Virology. 1999 Sep 1;261(2):242-52. Unique Identifier : AIDSLINE MED/99428760; Zhang W; Auyong DB; Oaks JL; McGuire TC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington 99164-7040, USA.; Two defined cytotoxic T lymphocyte (CTL) epitopes from equine infectious anemia virus (EIAV)-infected horses, equine leukocyte alloantigen (ELA)-A5.1-restricted epitope 18a, and ELA-A9-restricted epitope 28b-1 were evaluated for conservation among three wild-type EIAV strains. Epitope 18a variation occurred in all thr
Drug network characteristics as a predictor of cessation of drug use among adult injection drug users: a prospective study.: Am J Drug Alcohol Abuse. 1999 Aug;25(3):463-73. Unique Identifier : AIDSLINE MED/99399988; Latkin CA; Knowlton AR; Hoover D; Mandell W; Department of Health Policy and Management, The Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA. clatkinjhsph.edu.; Few studies have examined recovery from opiate and cocaine dependence without treatment, referred to as natural recovery, spontaneous recovery, and spontaneous remission. The present study examined the relationship between network characteristics and cessation of heroin, cocaine, and crack use in a sample of und
Methamphetamine use and sexual and injection risk behaviors among out-of-treatment injection drug users.: Am J Drug Alcohol Abuse. 1999 Aug;25(3):475-93. Unique Identifier : AIDSLINE MED/99399989; Molitor F; Ruiz JD; Flynn N; Mikanda JN; Sun RK; Anderson R; California Department of Health Services, Office of AIDS, USA.; fmolitor@ucdavis.edu; Our primary objective was to examine the relationship between methamphetamine use and sexual risk-taking behaviors--number of sexual partners, frequency of sexual behaviors with regular and casual partners, trading money or drugs for sex, and condom use--among male and female out-of-treatment injection drug users (OTI
Modified therapeutic community for homeless mentally ill chemical abusers: emerging subtypes.: Am J Drug Alcohol Abuse. 1999 Aug;25(3):495-515. Unique Identifier : AIDSLINE MED/99399990; De Leon G; Sacks S; Staines G; McKendrick K; Center for Therapeutic Community Research, National Development; and Research Institutes, Incorporated, New York, New York, USA.; This paper is one of a series reporting on a clinical field trial evaluating the efficacy of the modified therapeutic community (TC) approach for the treatment of homeless mentally ill chemical abusers (MICAs). The social and psychological characteristics of the treatment sample were described in an earlier paper; the
Beyond HIV viral load testing [news]: Ann Intern Med. 1999 Oct 19;131(8):637-8. Unique Identifier : AIDSLINE MED/99441166; Kane B
A new contained human immunodeficiency virus type 1 host cell system for evaluation of antiviral activities of interferons and other agents in vitro.: Antiviral Res. 1999 Jul;42(3):177-87. Unique Identifier : AIDSLINE MED/99371130; Moussazadeh M; Hua J; Sidhu MK; Zhao XX; Fitzgibbon JE; Liao MJ; Rashidbaigi A; Interferon Sciences Inc., New Brunswick, NJ 08901, USA.; HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and rev (TART) genes of
Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.: Antiviral Res. 1999 Jul;42(3):189-96. Unique Identifier : AIDSLINE MED/99371131; Cardona VM; Ayi AI; Aubertin AM; Guedj R; Laboratoire de Chimie Bio-Organique CNRS ESA 6001, Universite de; Nice-Sophia Antipolis, Faculte des Sciences, Nice, France.; Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues ( AZT and d4T ) were prepared as potential prodrugs of the bio-active free nucleotide and they were evaluated fo
Anti-HIV activity of amphotericin B-cholesteryl sulfate colloidal dispersion in vitro.: Antiviral Res. 1999 Jul;42(3):197-209. Unique Identifier : AIDSLINE MED/99371132; Konopka K; Guo LS; Duzgunes N; Department of Microbiology, University of the Pacific School of; Dentistry, San Francisco, CA 94115, USA.; We examined whether the anti-HIV-1 activity of the polyene antibiotic Amphotericin B (AMB) is retained following incorporation into sterically stabilized Stealth liposomes (L-AMB) with prolonged circulation in vivo, or cholesteryl sulfate colloidal dispersions (CD-AMB). The effects of the different preparations on a
Lipoproteins account for part of the broad non-specific antiviral activity of human serum.: Antiviral Res. 1999 Jul;42(3):211-8. Unique Identifier : AIDSLINE MED/99371133; Singh IP; Chopra AK; Coppenhaver DH; Ananatharamaiah GM; Baron S; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555-1019, USA.; Several antiviral substances have been detected in human serum but few have been shown to possess broad antiviral activity. These broadly active antiviral molecules could be of significance as innate defense mechanisms. We have previously identified and characterized a broadly antiviral glycoprotein, UTI3, which accou
GB virus C/hepatitis G virus infection in HIV infected patients with haemophilia despite treatment with virus inactivated clotting factor concentrates.: Arch Dis Child. 1999 May;80(5):429-32. Unique Identifier : AIDSLINE MED/99386590; Woelfle J; Berg T; Bialek R; Keller KM; Effenberger W; Wagner N; Department of Paediatrics, Children's Hospital, University of; Bonn, 53113 Bonn, Germany.; AIM: To determine the frequency of GB virus C (GBV-C)/hepatitis G virus (HGV) infection before and after switch to the use of virus inactivated concentrates in haemophiliac patients infected with human immunodeficiency virus (HIV). PATIENTS AND METHODS: Initial and follow up sera from 49 children with haemophilia were
Recombinant vaccinia viruses expressing an immunodominant epitope of HIV-1 envelope protein within an influenza hemagglutinin cassette predominantly prime epitope-specific CD8(+) CTL.: Arch Virol. 1999;144(8):1469-85. Unique Identifier : AIDSLINE MED/99415684; Chiba M; Takahashi H; Kato K; Nakagawa Y; Fukushima T; Iinuma H; Nerome K; Medical Development Department of the Nisshin Oil Mills, Ltd.,; Yokohama, Japan.; We constructed recombinant vaccinia viruses (RVV) expressing a 15-residue peptide (P18IIIB; RIQRGPGRAFVTIGK) of gp160 envelope protein from a human immunodeficiency virus type-1 (HIV-1) IIIB isolate using an H1 influenza virus hemagglutinin (HA) gene cassette. Immunofluorescent tests with antisera against both H1N1 in
Syringohydromyelia or HTLV-I-associated myelopathy/tropical spastic paraparesis. A diagnostic challenge. Case report.: Arq Neuropsiquiatr. 1999 Jun;57(2A):284-7. Unique Identifier : AIDSLINE MED/99341042; Araujo A de Q; Leite AC; De Oliveira AL; Afonso CR; Pies J; HTLV Unit, Evandro Chagas Hospital, FIOCRUZ, RJ, Brasil.; Human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the most common chronic myelopathy in Brazil . We present the case of a 53 year old man that fulfilled the diagnostic criteria for HAM/TSP but had at the magnetic resonanc
[Internal carotid bilateral occlusion, meningovascular syphilis and AIDS: case report]: Arq Neuropsiquiatr. 1999 Jun;57(2A):311-6. Unique Identifier : AIDSLINE MED/99341048; Lambrecht F; De Sa DS; Koerbel A; Tamanini A; Machareth SL; Scola RH; Teive HG; Werneck LC; Departamento de Clinica Medica, Hospital de Clinicas,; Universidade Federal do Parana, Brasil.; We report a case of bilateral occlusion of internal carotid arteries, presenting with right hemiparesis and hypoesthesia, associated to meningovascular syphilis in a patient with AIDS. CT scan showed few small hypodense lesions, with a predominance on the left side, and the angiography showed bilateral occlusion of th
Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.: Biochem Pharmacol. 1999 Sep 15;58(6):935-50. Unique Identifier : AIDSLINE MED/99437445; Ekholm D; Mulloy JC; Gao G; Degerman E; Franchini G; Manganiello VC; Pulmonary-Critical Care Medicine Branch, National Heart, Lung and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892-1434, USA.; Intracellular cyclic AMP, determined in part by cyclic nucleotide phosphodiesterases (PDEs), regulates proliferation and immune functions in lymphoid cells. Total PDE, PDE3, and PDE4 activities were measured in phytohemagglutinin (PHA)-activated peripheral blood mononuclear cells (PBMC-PHA), normal natural killer (NK)
Catastrophe model for the exposure to blood-borne pathogens and other accidents in health care settings.: Accid Anal Prev. 1999 Nov;31(6):739-49. Unique Identifier : AIDSLINE MED/99415271; Guastello SJ; Gershon RR; Murphy LR; Department of Psychology, Marquette University, Milwaukee, WI; 53201-1881, USA. 6155guastell@vms.csd.mu.edu; Catastrophe models, which describe and predict discontinuous changes in system state variables, were used to model the exposure to blood and bodily fluids and more conventional occupational accidents among 1708 health care workers. Workers at three hospitals completed a survey measuring HIV-relevant exposures (needles
Disappearance of hepatitis B virus core deletion mutants and successful combined kidney/liver transplantation in a patient treated with lamivudine.: Transpl Int. 1999;12(4):283-7. Unique Identifier : AIDSLINE MED/99391597; Meisel H; Preikschat P; Reinke P; Hocher B; Budde K; Bechstein WO; Neuhaus P; Kruger DH; Neumayer HH; Department of Medical Virology, Charite, Humboldt Universitat; Berlin, Augustenburger Platz 1, D-13 353 Berlin, Germany.; Hepatitis B virus (HBV) core deletion variants with enhanced viral replication are associated with rapid deterioration of liver function in renal allograft recipients. Antiviral agents such as famciclovir and lamivudine offer new treatment strategies for these patients. Appearance, accumulation and persistence of HBV
Thymic involution and HIV progression [letter]: Immunol Today. 1999 Sep;20(9):429. Unique Identifier : AIDSLINE MED/99393353; Beltz L
Comparative tolerability of therapies for cytomegalovirus retinitis.: Drug Saf. 1999 Sep;21(3):203-24. Unique Identifier : AIDSLINE MED/99415339; Walmsley S; Tseng A; Immunodeficiency Clinic, The Toronto Hospital, Department of; Medicine, University of Toronto, Ontario, Canada.; swalmsley@torhosp.toronto.on.ca; Cytomegalovirus ( CMV ) retinitis is a potentially sight-threatening complication of advanced HIV infection. The acute infection can be controlled with one of several therapies, including intravenous ganciclovir, foscarnet or cidofovir, slow release ganciclovir in
FUO and AIDS.: Curr Clin Top Infect Dis. 1999;19:1-15. Unique Identifier : AIDSLINE MED/99401697; Sepkowitz KA; Cornell University Medical College, New York, New York, USA.
Cytomegalovirus: disease syndromes and treatment.: Curr Clin Top Infect Dis. 1999;19:16-29. Unique Identifier : AIDSLINE MED/99401698; Drew WL; Lalezari JP; Laboratory Medicine and Medicine, University of California, San; Francisco, USA.
Rhodococcus equi infections: clinical features and laboratory diagnosis.: Curr Clin Top Infect Dis. 1999;19:198-215. Unique Identifier : AIDSLINE MED/99401707; Cornish N; Washington JA; Methodist and Children's Hospitals, Omaha, Nebraska, USA.
Human immunodeficiency virus disease in the era of HAART: a reevaluation of the mucocutaneous manifestations.: Curr Clin Top Infect Dis. 1999;19:252-86. Unique Identifier : AIDSLINE MED/99401710; Johnson RA; Beth Israel Deaconess Medical Center, Division of Dermatology,; Boston, Massachusetts, USA.
Efficacy of a five-drug combination including ritonavir, saquinavir and efavirenz in patients who failed on a conventional triple-drug regimen: phenotypic resistance to protease inhibitors predicts outcome of therapy.: Unique Identifier : AIDSLINE MED/99376517; Piketty C; Race E; Castiel P; Belec L; Peytavin G; Si-Mohamed A; Gonzalez-Canali G; Weiss L; Clavel F; Kazatchkine MD; Unite d'Immunologie, Hopital Broussais and Universite Pierre; et Marie Curie, Paris, France.; OBJECTIVE: to assess the safety and efficacy of a combination of ritonavir , efavirenz and two recycled nucleosides in patients who failed on a conventional triple-drug regimen includi
Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy.: AIDS. 1999 Jul 30;13(11):F79-86. Unique Identifier : AIDSLINE MED/99376518; Garcia F; Plana M; Vidal C; Cruceta A; O'Brien WA; Pantaleo G; Pumarola T; Gallart T; Miro JM; Gatell JM; Infectious Diseases Unit, Institut d'Investigacions Biomediques; August Pi I Sunyer Hospital Clinic, Faculty of Medicine,; University of Barcelona, Spain.; BACKGROUND: This study addresses the dynamic of viral load rebound and immune system changes in a cohort of eight consecutive HIV-1-infected patients in very early stages [all the patients were taking highly active antiretroviral therapy (HAART} and were recruited in the coordinating center from a larger study] who de
Virological and immunological responses to once-daily dosing of didanosine in combination with stavudine. AI454-143 Team.: AIDS. 1999 Jul 30;13(11):F87-93. Unique Identifier : AIDSLINE MED/99376519; Mobley JE; Pollard RB; Schrader S; Adler MH; Kelleher T; McLaren C; Cooper Green Hospital, Birmingham, AL, USA.; OBJECTIVE: To compare the antiviral activity of once-daily didanosine (ddI) and twice-daily ddI in combination with stavudine ( d4T ). DESIGN: Randomized, double-blind, multicenter stud
AIDS vaccine research in Asia: needs and opportunities. Report from a UNAIDS/WHO/NIID meeting Tokyo, 28-30 October 1998.: AIDS. 1999 Jul 30;13(11):UNAIDS 1-UNAIDS 13. Unique Identifier : AIDSLINE MED/99376513; A meeting was organized by the Joint United Nations Programme on HIV/AIDS ( UNAIDS ), the World Health Organisation (WHO) and the Japanese National Institute of Infectious Diseases (NIID) with the following objectives: (i) to discuss public health and economic rationale to accelerate
The International Conference on AIDS. Why we chose South Africa.: AIDS. 1999 Jul 30;13(11):11-2. Unique Identifier : AIDSLINE MED/99376516; Wainberg MA; Kallings LO; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Canada.
Epidemiological and clinical aspects of the metabolic complications of HIV infection the fat redistribution syndrome [editorial]: AIDS. 1999 Jul 30;13(11):1287-93. Unique Identifier : AIDSLINE MED/99376520; Wanke CA
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.: AIDS. 1999 Jul 30;13(11):1295-303. Unique Identifier : AIDSLINE MED/99376521; Andersson J; Behbahani H; Lieberman J; Connick E; Landay A; Patterson B; Sonnerborg A; Lore K; Uccini S; Fehniger TE; Department of Infectious Diseases, Karolinska Institutet,; Huddinge University Hospital, Stockholm, Sweden.; BACKGROUND: Residual HIV-1-infected cells are poorly eliminated from lymphoid tissue (LT) reservoirs by effector cytotoxic T lymphocytes (eCTL) despite antiretroviral therapy. Perforin and granzyme A (grA) constitute major effector molecules within eCTL granules that induce apoptosis and lysis of virally infected cell
HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS.: AIDS. 1999 Jul 30;13(11):1305-11. Unique Identifier : AIDSLINE MED/99376522; Abebe A; Demissie D; Goudsmit J; Brouwer M; Kuiken CL; Pollakis G; Schuitemaker H; Fontanet AL; Rinke de Wit TF; Ethiopian-Netherlands AIDS Research Project, Ethiopian Health and; Nutrition Research Institute, Addis Ababa. enarp@telecom.net.et; OBJECTIVE: To assess syncytium-inducing (SI) and non-syncytium-inducing (NSI) frequencies, coreceptor usage and gp120 V3 sequences of HIV-1 isolates from Ethiopian AIDS patients. PATIENTS: Cross-sectional study on 48 hospitalized AIDS patients (CD4 T cells
Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus-coinfected patients.: AIDS. 1999 Jul 30;13(11):1313-22. Unique Identifier : AIDSLINE MED/99376523; Woitas RP; Rockstroh JK; Beier I; Jung G; Kochan B; Matz B; Brackmann HH; Sauerbruch T; Spengler U; Department of Internal Medicine I, University of Bonn, Germany.; woitas@uni-bonn.de; OBJECTIVE: Epidemiological data indicate that hepatitis C virus (HCV) infection runs a more rapid and severe course of disease in HIV-coinfected patients, probably because of an altered immune response. DESIGN: We investigated whether HCV-specific cytokine responses are affected by HIV coinfection. METHODS: Using trip
Compartmentalization of the IgG immune response to HIV-1 in breast milk.: AIDS. 1999 Jul 30;13(11):1323-31. Unique Identifier : AIDSLINE MED/99376524; Becquart P; Hocini H; Garin B; Sepou A; Kazatchkine MD; Belec L; Unite INSERM U430, Hopital Broussais, Paris, France.; OBJECTIVE: To evaluate the IgG immune response to HIV-1 in colostrum. METHODS: Paired serum and colostrum were collected from 16 asymptomatic HIV-1-infected women. IgG to gp160 and to four peptides (gp41 immunodominant DI domain, gp41/Id; EDLKWA epitope of DIII domain, gp41/K; gp120 C-terminus, gp120/Ct; V3 loop, gp12
Reduction of IFN-gamma and IL-2 production by peripheral lymphocytes of HIV-exposed seronegative subjects.: AIDS. 1999 Jul 30;13(11):1333-6. Unique Identifier : AIDSLINE MED/99376525; Nicastri E; Sarmati L; Ercoli L; Mancino G; D'Ambrosio E; d'Ettorre G; Mastroianni CM; Vullo V; Andreoni M; Infectious Diseases Department, University of Rome Tor Vergata,; Italy.; OBJECTIVES: In order to evaluate the role played by cytokine profile as a co-factor involved in the resistance to HIV infection in couples serodiscordant for HIV, we studied HIV-seronegative subjects with multiple unprotected sexual exposures. DESIGN AND METHODS: Twenty-one HIV-exposed seronegative subjects (HEPS), th
Detectable HIV-1 RNA at levels below quantifiable limits by amplicor HIV-1 monitor is associated with virologic relapse on antiretroviral therapy.: AIDS. 1999 Jul 30;13(11):1337-42. Unique Identifier : AIDSLINE MED/99376526; Pilcher CD; Miller WC; Beatty ZA; Eron JJ; Department of Medicine, University of North Carolina at Chapel; Hill, 27599-7030, USA.; OBJECTIVE: To assess the clinical significance of HIV-1 RNA levels detectable using the Amplicor HIV-1 Monitor method but
Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential.: AIDS. 1999 Jul 30;13(11):1343-9. Unique Identifier : AIDSLINE MED/99376527; Keulen W; van Wijk A; Schuurman R; Berkhout B; Boucher CA; Department of Virology, Eijkman-Winkler Institute, University; Hospital of Utrecht, The Netherlands.; OBJECTIVE: Anti HIV-1 therapy with nucleoside reverse transcriptase inhibitors can select for drug-resistant reverse transcriptase variants with altered enzyme properties. Some of the mutations, e.g. Met184Val and Met184Ile, result in an increase in polymerase fidelity of the enzyme as measured in biochemical assays;
Elevated resting energy expenditure among HIV-seropositive persons receiving highly active antiretroviral therapy.: AIDS. 1999 Jul 30;13(11):1351-7. Unique Identifier : AIDSLINE MED/99376528; Shevitz AH; Knox TA; Spiegelman D; Roubenoff R; Gorbach SL; Skolnik PR; Department of Family Medicine and Community Health, Tufts; University School of Medicine, Boston, Massachusetts, USA.; OBJECTIVES: To ascertain the relationships between resting energy expenditure (REE), HIV RNA in plasma, and highly active antiretroviral therapy (HAART). DESIGN: Cross-sectional analysis using data of a large cohort study of nutrition in relation to HIV disease. METHODS: HIV RNA in plasma, REE, fat-free mass (FFM), an
Fasting hyperinsulinemia and increased waist-to-hip ratios in non-wasting individuals with AIDS.: AIDS. 1999 Jul 30;13(11):1359-65. Unique Identifier : AIDSLINE MED/99376529; Shikuma CM; Waslien C; McKeague J; Baker N; Arakaki M; Cui XW; Souza S; Imrie A; Arakaki R; Pacific Biomedical Research Center, Department of Medicine of the; John A. Burns School of Medicine, University of Hawaii-Manoa,; Honolulu, USA.; OBJECTIVE: To identify metabolic and body composition changes associated with HIV-1 infection in a cross-sectional study of individuals stratified by immunologic status and body mass. DESIGN: Metabolic abnormalities including glucose intolerance and changes in body morphology have recently been described in HIV-1-infe
Prevention of disseminated Mycobacterium avium complex infection with reduced dose clarithromycin in patients with advanced HIV disease.: AIDS. 1999 Jul 30;13(11):1367-72. Unique Identifier : AIDSLINE MED/99376530; Hewitt RG; Papandonatos GD; Shelton MJ; Hsiao CB; Harmon BJ; Kaczmarek SR; Amsterdam D; Department of Medicine, State University of New York at Buffalo,; USA.; OBJECTIVE: To evaluate the ability of once daily reduced dose clarithromycin to prevent disseminated Mycobacterium avium complex (dMAC) infection in patients with advanced HIV disease. DESIGN: Non-randomized, retrospective study. SETTING: Outpatient clinic of an urban university-affiliated municipal hospital. PATIENTS
A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution.: AIDS. 1999 Jul 30;13(11):1373-5. Unique Identifier : AIDSLINE MED/99376531; Roubenoff R; Weiss L; McDermott A; Heflin T; Cloutier GJ; Wood M; Gorbach S; Department of Community Health, Tupper Research Institute, Tufts; University School of Medicine, Jean Mayer USDA Human Nutrition; Research Center on Aging at Tufts University, Boston, MA 02111,; USA. roubenoff@hnrc.tufts.edu; OBJECTIVE: Body fat redistribution ( lipodystrophy ), with gain in abdominal and trunk fat, and decline in facial and limb fat, is a newly recognized problem in patients with HIV infection that has been linked to use of HIV-1 protease inhibitors . Increased abdominal
Maternal viral load and vertical transmission of HIV-1: an important factor but not the only one. The European Collaborative Study.: AIDS. 1999 Jul 30;13(11):1377-85. Unique Identifier : AIDSLINE MED/99376532; OBJECTIVES: To investigate the association between maternal RNA load, risk of vertical transmission of HIV-1, and other variables. METHODS: Plasma or serum samples from mothers of 373 children, enrolled in the prospective European Collaborative Study, were collected around time of delivery, and HIV-RNA quantified usin
New HIV cases attributable to syphilis in the USA: estimates from a simplified transmission model.: AIDS. 1999 Jul 30;13(11):1387-96. Unique Identifier : AIDSLINE MED/99376533; Chesson HW; Pinkerton SD; Irwin KL; Rein D; Kassler WJ; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; OBJECTIVE: Because syphilis can raise the likelihood of HIV transmission and acquisition, syphilis prevention in the USA has the potential benefit of reducing the number of new cases of HIV. We developed a simplified transmission model to estimate the annual number and cost of new, heterosexually-acquired HIV cases in
Low and stable HIV infection rates in Senegal: natural course of the epidemic or evidence for success of prevention?: AIDS. 1999 Jul 30;13(11):1397-405. Unique Identifier : AIDSLINE MED/99376534; Meda N; Ndoye I; M'Boup S; Wade A; Ndiaye S; Niang C; Sarr F; Diop I; Carael M; Centre MURAZ, Organisation de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies, Bobo-Dioulasso,; Burkina Faso, West Africa.; OBJECTIVES: To document the level of HIV infection in Senegal and also to review evidence of the impact of efforts in prevention, developed by the National AIDS Control Programme and the Civil Society, on the level of the HIV epidemic. METHODS: Research, compilation and critical r
Sexual risk behaviour among gay men in a relationship.: AIDS. 1999 Jul 30;13(11):1407-11. Unique Identifier : AIDSLINE MED/99376535; Elford J; Bolding G; Maguire M; Sherr L; Department of Primary Care and Population Sciences and Royal Free; Centre for HIV Medicine, Royal Free and University College; Medical School, University College London, UK.; OBJECTIVE: To examine whether gay men in a relationship have adopted negotiated safety as an HIV risk reduction strategy. METHODS: A confidential, anonymous questionnaire was completed by 1004 gay men attending gyms in central London in September-October 1997. Information was sought on sociodemographic characteristics
HLA-A*1101-restricted cytotoxic T lymphocyte recognition of HIV-1 Pol protein [letter]: AIDS. 1999 Jul 30;13(11):1413-4. Unique Identifier : AIDSLINE MED/99376536; Fukada K; Chujoh Y; Tomiyama H; Miwa K; Kaneko Y; Oka S; Takiguchi M
Sex differences in HIV-1 viral load and TNF-alpha plasmatic level? [letter]: AIDS. 1999 Jul 30;13(11):1414-5. Unique Identifier : AIDSLINE MED/99376537; Saves M; Morlat P; Chene G; Dumon B; Peuchant E
Improved estimates for HIV-1 clearance rate and intracellular: Unique Identifier : AIDSLINE MED/99376538
Use of a new 'less-sensitive enzyme immunoassay' testing strategy to identify recently infected persons in a Brazilian prison: estimation of incidence and epidemiological tracing [letter]: AIDS. 1999 Jul 30;13(11):1417-8. Unique Identifier : AIDSLINE MED/99376539; Diaz RS; Kallas EG; Castelo A; Rawal BD; Busch MP
The impact of highly active antiretroviral therapy on HIV-related hospitalizations in 17 county hospitals in Catalonia, Spain. Catalonian County Hospitals HIV Infection Study Group [letter]: AIDS. 1999 Jul 30;13(11):1418-9. Unique Identifier : AIDSLINE MED/99376540; Altes J; Guadarrama M; Force L; Tapiz A; Vilaro J; Garcia I
Abacavir rechallenge has to be avoided in case of hypersensitivity reaction [letter]: AIDS. 1999 Jul 30;13(11):1419-20. Unique Identifier : AIDSLINE MED/99376541; Escaut L; Liotier JY; Albengres E; Cheminot N; Vittecoq D
Agranulocytosis induced by abacavir [letter]: AIDS. 1999 Jul 30;13(11):1420-1. Unique Identifier : AIDSLINE MED/99376542; Tikhomirov V; Namek K; Hindes R
Severe acute pancreatitis related to the use of nelfinavir in HIV infection: report of a case with positive rechallenge [letter]: AIDS. 1999 Jul 30;13(11):1421-3. Unique Identifier : AIDSLINE MED/99376543; Di Martino V; Ezenfis J; Benhamou Y; Bernard B; Opolon P; Bricaire F; Poynard T
Substituting nevirapine for protease inhibitors because of intolerance [letter]: AIDS. 1999 Jul 30;13(11):1423-4. Unique Identifier : AIDSLINE MED/99376544; Dieleman JP; Gyssens IC; Sturkenboom MJ; Niesters HG; van der Ende ME
Atorvastatin for protease inhibitor-related hyperlipidaemia [letter]: AIDS. 1999 Jul 30;13(11):1424-5. Unique Identifier : AIDSLINE MED/99376545; Murillas J; Martin T; Ramos A; Portero JL
Deep venous thrombosis and megestrol in patients with HIV infection [letter]: AIDS. 1999 Jul 30;13(11):1425-6. Unique Identifier : AIDSLINE MED/99376546; Force L; Barrufet P; Herreras Z; Bolibar I
Contrast-enhancing progressive multifocal leukoencephalopathy as an immune reconstitution event in AIDS patients [letter]: AIDS. 1999 Jul 30;13(11):1426-8. Unique Identifier : AIDSLINE MED/99376547; Collazos J; Mayo J; Martinez E; Blanco MS
Public attitudes towards needle exchange programs [letter]: AIDS. 1999 Jul 30;13(11):1428-9. Unique Identifier : AIDSLINE MED/99376548; Quinn SC
Long-term antiretroviral combination therapy including lamivudine in HIV-1 infected women during pregnancy [letter]: AIDS. 1999 Jul 30;13(11):1430-1. Unique Identifier : AIDSLINE MED/99376549; Grubert TA; Wintergerst U; Lutz-Friedrich R; Belohradsky BH; Rolinski B
Reply: Treatment of tuberculosis in HIV-infected patients [letter]: AIDS. 1999 Jul 30;13(11):1431-2. Unique Identifier : AIDSLINE MED/99376550; Pozniak AL; Ormerod LP; Miller R
IAS position paper on prevention of HIV 1 mother-to-child transmission. International Aids Society.: AIDS. 1999 Jul 30;13(11):5-9. Unique Identifier : AIDSLINE MED/99376514
HIV and AIDS in Asia--the current state of affairs.: AIDS. 1999 Jul 30;13(11):9-10. Unique Identifier : AIDSLINE MED/99376515; Brown T; East-West Center, Honolulu, Hawaii, USA.
Mucosal infection and vaccination against feline immunodeficiency virus.: J Biotechnol. 1999 Aug 20;73(2-3):213-21. Unique Identifier : AIDSLINE MED/99416398; Stokes CR; Finerty S; Gruffydd-Jones TJ; Sturgess CP; Harbour DA; Division of Molecular and Cellular Biology, University of; Bristol, UK. chris.stokes@bris.ac.uk; Feline immunodeficiency virus (FIV) infection is a naturally occurring lentiviral infection of cats which progresses to immunodeficiency in a manner strikingly similar to that observed in HIV infection in man. The rectal and cervico-vaginal mucosae are common routes of transmission of HIV and it has been shown that th
Expression of bcl-2 protein in lymphocytes of patients with laryngeal carcinoma.: Eur Arch Otorhinolaryngol. 1999;256(6):299-302. Unique Identifier : AIDSLINE MED/99385238; Klatka J; Rolinski J; Kupisz K; Klonowski S; Skomra D; Otolaryngology Department, Medical Academy, Lublin, Poland.; The aim of this study was to evaluate the expression of bcl-2 protein in lymphocytes of the peripheral blood of patients with laryngeal carcinoma. The protein product of the proto-oncogene bcl-2 is a physiological inhibitor of apoptosis or programmed cell death. Since we believe that apoptosis is involved in the regul
The macroimportance of the pulmonary immune microenvironment.: Am J Respir Cell Mol Biol. 1999 Sep;21(3):298-302. Unique Identifier : AIDSLINE MED/99391615; Lee NA; Lee JJ; Department of Biochemistry and Molecular Biology, Samuel C.; Johnson Medical Research Building, Mayo Clinic Scottsdale,; Scottsdale, Arizona, USA. nlee@mayo.edu
Cytokine gene therapy of mesothelioma. Immune and antitumor effects of transfected interleukin-12.: Am J Respir Cell Mol Biol. 1999 Sep;21(3):347-56. Unique Identifier : AIDSLINE MED/99391621; Caminschi I; Venetsanakos E; Leong CC; Garlepp MJ; Robinson BW; Scott B; Department of Medicine, University of Western Australia;; Australian Neuromuscular Research Institute, Queen Elizabeth II; Medical Centre, Nedlands, Australia.; Malignant mesothelioma (MM) is a solid tumor of the mesothelium for which there is no curative treatment. MM appears to be sensitive to immunotherapeutic approaches, and one of the most powerful immunomodulatory cytokines with antitumor effects is interleukin (IL)-12. We have previously shown in a murine model of MM t
[Otomastoiditis by Aspergillus fumigatus in a patient with AIDS [letter]]: Acta Otorrinolaringol Esp. 1999 Apr;50(3):247-8. Unique Identifier : AIDSLINE MED/99460028; Lizarralde E; Teira R; Zubero Z; Baraia-Etxaburo J; Fiz J; Santamaria JM
Elusive realities: a perspective on the Chicago retrovirus meeting.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1149-50. Unique Identifier : AIDSLINE MED/99408504; Harris PJ; US Bioscience, Inc., W. Conshohocken, Pennsylvania 19428, USA.; pamela.harris@usbio.com
HIV type 1 tat gene heteroduplex mobility assay as a tool to establish epidemiologic relationships among HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1151-6. Unique Identifier : AIDSLINE MED/99408505; Diaz RS; De Oliveira CF; Pardini R; Operskalski E; Mayer AJ; Busch MP; Blood Centers of the Pacific, Irwin Center, San Francisco,; California 94118, USA.; Molecular biology techniques are increasingly used to study the molecular epidemiology of infectious diseases. Most of these methods are expensive and labor-intensive. The human immunodeficiency virus (HIV) has substantial genomic variation, such that HIVs from different individuals are genetically diverse, although m
Genetic similarity of HIV type 1 subtype E in a recent outbreak among injecting drug users in northern Vietnam to strains in Guangxi Province of southern China.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1157-68. Unique Identifier : AIDSLINE +; Kato K; Shiino T; Kusagawa S; Sato H; Nohtomi K; Shibamura K; Nguyen TH; Pham KC; Truong XL; Mai HA; Hoang TL; Bunyaraksyotin G; Fukushima Y; Honda M; Wasi C; Yamazaki S; Nagai Y; Takebe Y; Laboratory of Molecular Virology and Epidemiology, AIDS Research; Center, National Institute of Infectious Disease, Tokyo, Japan.; To investigate the molecular epidemiology of a recent HIV-1 outbreak in northern Vietnam and its relation to the epidemic in surrounding areas, we analyzed 17 HIV-positive blood specimens from 3 heterosexuals, 2 sexually transmitted disease patients, and 12 injecting drug users (I
Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1169-79. Unique Identifier : AIDSLINE MED/99408507; Haslett PA; Klausner JD; Makonkawkeyoon S; Moreira A; Metatratip P; Boyle B; Kunachiwa W; Maneekarn N; Vongchan P; Corral LG; Elbeik T; Shen Z; Kaplan G; The Laboratory of Cellular Physiology and Immunology, The; Rockefeller University, New York, New York 10021, USA.; hasletp@rockvax.rockefeller.edu; We performed a placebo-controlled study to evaluate the effects of immunomodulatory treatment with thalidomide on HIV levels, TNF-alpha levels, and immune status of 31 HIV-infected individuals, after temporary suppression of viral replication with antiretroviral drugs. Treatment with a combination of zidovudine and la
The rabbit study: ritonavir and saquinavir in combination in saquinavir-experienced and previously untreated patients.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1181-9. Unique Identifier : AIDSLINE MED/99408508; Churchill DR; Pym AS; Galpin S; Foxall R; Stainsby C; Clarke JR; Kaye S; Bloor S; Larder BA; Wills B; Sun E; Babiker AG; Back DJ; Weber JN; Division of Medicine, Imperial College School of Medicine, St.; Mary's Hospital, London, UK. DuncanChurchill@ukf.net; Thirteen protease inhibitor-naive patients with HIV-1 infection, and 12 patients with a median of 58 months prior treatment with saquinavir (SQV) monotherapy, were treated with SQV (400 mg twice daily) and ritonavir (RIT, 500 mg twice daily) in a stud
Rapid screening of phenotypic resistance to nevirapine by direct analysis of HIV type 1 reverse transcriptase activity in plasma.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1191-200. Unique Identifier : AIDSLINE MED/99408509; Vazquez-Rosales G; Garcia Lerma JG; Yamamoto S; Switzer WM; Havlir D; Folks TM; Richman DD; Heneine W; HIV and Retrovirology Branch, Division of AIDS, STD, and TB; Laboratory Research, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Drug susceptibility testing for the clinical management of human immunodeficiency virus type 1 (HIV-1)-infected persons is often curtailed because such testing is expensive and time consuming. We describe a non-culture-based phenotypic assay for the rapid analysis of HIV-1 resistance to
Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1201-8. Unique Identifier : AIDSLINE MED/99408510; Xiao L; Weiss SH; Qari SH; Rudolph D; Zhao C; Denny TN; Hodge T; Lal RB; HIV and Retrovirology Branch, Division of AIDS, STD, TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; It is known that certain individuals remain persistently seronegative despite repeated exposure to HIV-1. Studies have shown that some exposed uninfected (EU) individuals who are homozygous for a 32-bp deletion in the CCR5 gene are resistant to infection with non-syncytium-inducing (R5) viruses. In the present investi
Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1209-18. Unique Identifier : AIDSLINE MED/99408511; Blazquez MV; Macho A; Ortiz C; Lucena C; Lopez-Cabrera M; Sanchez-Madrid F; Munoz E; Departamento de Fisiologia e Immunologia, Universidad de; Cordoba, Cordoba, Spain.; The HIV-1 Tat protein, essential for HIV-1 gene expression and viral replication, is known to be secreted by infected cells and has pleiotropic effects on various cell functions. It seems that extracellular Tat may exert its functions on cellular targets by at least two different mechanisms, namely, by adsorptive endo
Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors.: AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1219-28. Unique Identifier : AIDSLINE MED/99408512; Betts MR; Krowka JF; Kepler TB; Davidian M; Christopherson C; Kwok S; Louie L; Eron J; Sheppard H; Frelinger JA; Department of Microbiology and Immunology, University of North; Carolina at Chapel Hill, 27599, USA.; HIV-1-specific cytotoxic T cell (CTL) activity has been suggested to correlate with protection from progression to AIDS. We have examined the relationship between HIV-specific CTL activity and maintenance of peripheral blood CD4+ T lymphocyte counts and control of viral load in 17 long-term survivors (LTSs) of HIV-1 i
HIV/AIDS risks among Native American drug users: key findings from focus group interviews and implications for intervention strategies.: AIDS Educ Prev. 1999 Aug;11(4):279-92. Unique Identifier : AIDSLINE MED/99424140; Baldwin JA; Trotter RT 2nd; Martinez D; Stevens SJ; John D; Brems C; Flagstaff Multicultural AIDS Prevention Project, Northern Arizona; University, Flagstaff 86011, USA. Julie.Baldwin@nau.edu; A multisite study funded through the National Institute on Drug Abuse and the Office of Research on Minority Health was conducted in 1996 to determine the HIV/AIDS prevention needs of Native American out-of-treatment drug users. In an effort to recommend directions for HIV/AIDS prevention programming, one component of
HIV risk reduction in outpatient drug abuse treatment: individual and geographic differences.: AIDS Educ Prev. 1999 Aug;11(4):293-306. Unique Identifier : AIDSLINE MED/99424141; Broome KM; Joe GW; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Fort Worth 76129, USA. ibr@tcu.edu; In the national Drug Abuse Treatment Outcome Studies (DATOS), many clients in outpatient methadone treatment (OMT) and outpatient drug-free (ODF) modalities were admitted with multiple sex and needle-risk behaviors, but they reduced these risks significantly during treatment. Using hierarchical linear model regression
Physicians' transmission prevention assessment and counseling practices with their HIV positive patients.: AIDS Educ Prev. 1999 Aug;11(4):307-20. Unique Identifier : AIDSLINE MED/99424142; Gerbert B; Brown B; Volberding P; Cooke M; Caspers N; Love C; Bronstone A; Department of Dental Public Health and Hygiene, University of; California San Francisco 94111, USA. gerbert@itsa.ucsf.edu; Physicians can help prevent transmission of HIV by assessing HIV positive patients for risky sexual and needle-sharing behaviors, and by providing risk reduction counseling. From 1995 to 1997, we gathered data on the HIV transmission prevention assessment and counseling practices of 44 San Francisco Bay area physician
Traumatic stress in HIV-infected women.: AIDS Educ Prev. 1999 Aug;11(4):321-30. Unique Identifier : AIDSLINE MED/99424143; Kimerling R; Calhoun KS; Forehand R; Armistead L; Morse E; Morse P; Clark R; Clark L; University of Georgia, Athens, USA. rachelk@itsa.ucsf.edu; This study assesses the prevalence of specific traumatic stressors that meet criterion A for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of posttraumatic stress disorder (PTSD) and symptoms of PTSD in a representative sample of HIV-infected women. The study also assesses the impact of
Are African American women worried about getting AIDS? A qualitative analysis.: AIDS Educ Prev. 1999 Aug;11(4):331-42. Unique Identifier : AIDSLINE MED/99424144; Cummings GL; Battle RS; Barker JC; Krasnovsky FM; Department of Epidemiology and Biostatistics, University of; California San Francisco 94143-0850, USA.; The aims of this study were to explore and describe AIDS-related worry among African American women and determine whether AIDS risk behaviors were associated with women s AIDS-related worry status. Of 142 women interviewed, 36% (n = 51) expressed some worry about getting AIDS, compared to 64% (n = 91) who did not expr
The association between characteristics of dating relationships and condom use among heterosexual young adults.: AIDS Educ Prev. 1999 Aug;11(4):343-52. Unique Identifier : AIDSLINE MED/99424145; Civic D; Center for Health Studies, Group Health Cooperative of Puget; Sound, Seattle, WA 98101, USA. civic.d@ghc.org; Although there is some evidence that relationship-level factors influence sexual behavior, they have received far less attention than individual-level factors as potential correlates of condom use. This study surveyed 210 undergraduate men and women to examine the association between relationship characteristics and c
Knowledge of HIV/AIDS among health care workers in China.: AIDS Educ Prev. 1999 Aug;11(4):353-63. Unique Identifier : AIDSLINE MED/99424146; Wu Z; Qi G; Zeng Y; Detels R; National Center for AIDS Prevention and Control, Chinese Academy; of Preventive Medicine, Beijing, China.; This study was designed to assess knowledge of AIDS among health professionals in China via a cross-sectional survey. A self-administered questionnaire requesting demographic characteristics and basic AIDS knowledge was given to health professionals in 11 provinces, cities, and auto
Geographical variations in AIDS knowledge and attitude among adolescent girls of Jamaica.: AIDS Educ Prev. 1999 Aug;11(4):364-72. Unique Identifier : AIDSLINE MED/99424147; Warren C; Research and Planning Services, Intl., Washington, DC 20033-0651,; USA.; This article examines geographical differences in AIDS knowledge and attitudes. Data from a survey of 900 adolescent girls in the Caribbean nation of Jamaica indicate significant differences across geography in AIDS knowledge and attitude. Adolescent girls in more central areas ha
Overexpression of monocyte-derived cytokines in active psoriasis: a relation to coexistent arthropathy.: J Dermatol Sci. 1999 Sep;21(1):63-70. Unique Identifier : AIDSLINE MED/99396270; Nishibu A; Han GW; Iwatsuki K; Matsui T; Inoue M; Akiba H; Kaneko R; Kaneko F; Department of Dermatology, Fukushima Medical University School of; Medicine, Japan.; An overexpression of inflammatory cytokines has been found in the lesional skin as well as peripheral blood in patients with psoriasis, although its etiological significance is not yet understood. In order to evaluate the cell type responsible for the elevated cytokines in the peripheral blood, we investigated cytokin
Characterization of the noncovalent complex of human immunodeficiency virus glycoprotein 120 with its cellular receptor CD4 by matrix-assisted laser desorption/ionization mass spectrometry.: Biochemistry. 1999 Sep 7;38(36):11734-40. Unique Identifier : AIDSLINE MED/99444097; Borchers C; Tomer KB; Laboratory of Structural Biology, National Institute of; Environmental Health Sciences, National Institutes of Health,; Research Triangle Park, North Carolina 27709, USA.; The initial event in infection by the human immunodeficiency virus type 1 (HIV-1) is the interaction of the viral envelope glycoprotein (HIV-gp120) with its primary cellular receptor, the glycoprotein CD4. Molecular structure information about the HIV-gp120/CD4 complex can provide information relevant to an understand
Flow cytometric analysis of thymocyte subpopulations in mice after whole-body X-irradiation.: J Vet Med Sci. 1999 Jun;61(6):709-12. Unique Identifier : AIDSLINE MED/99352497; Oka S; Kubo K; Matsuyama S; Takamori Y; Department of Veterinary Medicine, College of Agriculture, Osaka; Prefecture University, Japan.; To determined the cellular kinetics of thymocyte subpopulations in DBA1 mice after whole-body 6.8 Gy X-irradiation, they were analyzed for the expression of several cell surface antigens using flow cytometry. The results show that i) The majority of thymocytes rapidly depleted by irradiation was CD4+8+ cells. ii) radi
[Lumbosacral polyradiculomyelitis caused by herpes simplex virus (HSV) in a patient with AIDS]: An Med Interna. 1999 Aug;16(8):417-9. Unique Identifier : AIDSLINE MED/99437067; Miguelez M; Correa-Nazco VJ; Linares M; Laynez P; Gonzalez M; Martinez A; Servicio de Medicina Interna, Hospital Nuestra Senora de la; Candelaria, Santa Cruz de Tenerife.; To our knowledge this is the first description of lumbosacral polyradiculopathy produced by herpes simplex virus (HSV) without coinfection by cytomegalovirus ( CMV ) in a patient with HIV infection. The acute lumbosacral polyra
[Lumbosacral and meningeal polyradicular disease in a patient with HIV infection (letter)]: An Med Interna. 1999 Aug;16(8):435-6. Unique Identifier : AIDSLINE MED/99437073; Parra Rodenas JV; Riera Ayora M; Ronda Gasulla A; Herrera Ballester A
[Primary tuberculous psoas abscess in a patient with HIV infection (letter)]: An Med Interna. 1999 Aug;16(8):437-8. Unique Identifier : AIDSLINE MED/99437076; Salcedo M; Carmena J; Tornero C; Pons E
Impairment of HIV polymorphonuclear leukocyte transmigration across T84 cell monolayers: an alternative mechanisms for increased intestinal bacterial infections in AIDS?: Eur Cytokine Netw. 1999 Sep;10(3):373-82. Unique Identifier : AIDSLINE MED/99406364; Hofman P; Fischer F; Far DF; Selva E; Battaglione V; Bayle J; Rossi B; INSERM U. 364, Faculte de Medecine, avenue de Valombrose, 06107; Nice Cedex 01, France. hofman@unice.fr; Our objective was to study the influence of HIV infection of polymorphonuclear leukocytes (PMN) on transepithelial migration. To date, reports of functional PMN chemotaxis in AIDS are contradictory. This is the first attempt to assess this function via an in vitro model allowing transmigration of neutrophils through a
Lymphocyte subpopulations anomalies in lung cancer patients and relationship to the stage of disease.: In Vivo. 1999 May-Jun;13(3):205-9. Unique Identifier : AIDSLINE MED/99388784; Mazzoccoli G; Balzanelli M; Giuliani A; De Cata A; La Viola M; Carella AM; Bianco G; Tarquini R; Department of Internal Medicine, Regional General Hospital Casa; Sollievo della Sofferenza, Rotondo, Italy.; BACKGROUND: The host immune response is important in the natural history of neoplastic disease. In order to evaluate alterations of immune function associated with cancer we analyzed the nyctohemeral profile of lymphocyte subpopulations in peripheral blood of cancer patients. The study was carried out on seven healthy
Immunosuppression and reactivation of hepatitis B in the lamivudine era: opportunities for prevention and exploitation? [editorial; comment]: J Gastroenterol Hepatol. 1999 Aug;14(8):741-4. Unique Identifier : AIDSLINE MED/99410149; Farrell GC
Case report: lamivudine therapy for submassive hepatic necrosis due to reactivation of hepatitis B following chemotherapy [see comments]: J Gastroenterol Hepatol. 1999 Aug;14(8):801-3. Unique Identifier : AIDSLINE MED/99410158; Maguire CM; Crawford DH; Hourigan LF; Clouston AD; Walpole ET; Powell EE; Department of Gastroenterology and Hepatology, Princess Alexandra; Hospital, Brisbane, Queensland, Australia.; This report describes the case of a 53-year-old woman who developed severe hepatitis following chemotherapy for breast carcinoma. The patient was hepatitis B surface antigen positive, e antigen negative and e antibody positive and had high levels of hepatitis B virus-DNA. Liver biopsy revealed submassive hepatic necro
Case report: dramatic response to lamivudine therapy following corticosteroid priming in chronic hepatitis B [see comments]: J Gastroenterol Hepatol. 1999 Aug;14(8):804-6. Unique Identifier : AIDSLINE MED/99410159; Liaw YF; Chien RN; Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung; University, Taipei, Taiwan. liveryfl@tp.silkera.net; A 21 year-old male patient with chronic hepatitis B was treated with lamivudine 150 mg daily after withdrawal of a short course of oral prednisolone (30 mg daily for 3 weeks, 15 mg daily for 1 week). Serum hepatitis B virus (HBV)-DNA increased during prednisolone pretherapy and serum alanine aminotransferase (ALT) was
Stories of violence and shame [editorial]: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):15-6. Unique Identifier : AIDSLINE MED/99322861; Sowell RL
Two cultures, one epidemic.: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):19-26. Unique Identifier : AIDSLINE MED/99322862; Hall CM; Nokes KM; Hunter College, CUNY, Hunter-Bellevue School of Nursing, USA.; HIV infection is a global epidemic, and health care providers involved in HIV/AIDS care must be aware of how communities with different cultures, values, beliefs, and resources are coping. This article describes a 3-month volunteer experience with the Shona people of Zimbabwe , Af
HIV, pregnancy, and zidovudine: what do women know?: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):41-7. Unique Identifier : AIDSLINE MED/99322863; Vitiello MA; Smeltzer SC; HIV/AIDS Specialized Programs, Visiting Nurse Association of; Central Jersey Foundation, Inc., USA.; AIDS is a major cause of death among women and children, representing the fourth leading cause of death among women ages 25 to 44 and the seventh leading cause of death among children ages 1 to 4 in the United States . In 1994, National Institutes of Health announced the findings of the
Intervention for hyperlipidemia associated with protease inhibitors.: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):55-69. Unique Identifier : AIDSLINE MED/99322864; Melroe NH; Kopaczewski J; Henry K; Huebsch J; In the past 3 years, treatment for HIV infection has significantly improved the prognosis for HIV-infected persons. The administration of protease inhibitors for the treatment of HIV infection has had a significant role in the reduction of AIDS-related complications
A case study: the use of cidofovir for the management of progressive multifocal leukoencephalopathy.: Unique Identifier : AIDSLINE MED/99322865
Adherence to combination therapy in persons living with HIV: balancing the hardships and the blessings.: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):75-84. Unique Identifier : AIDSLINE MED/99322866; Erlen JA; Mellors MP; Center for Research in Chronic Disorders, School of Nursing,; University of Pittsburgh, USA.; Evidence from clinical trials demonstrates the benefits of combination therapy in persons living with HIV (PLWHIV); however, there is little information about the patient s experience when taking a complex regimen. Thus, the primary purpose of this preliminary study wa
Chicago ANAC nurses find mock drug trial informative--and fun!: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):85-7. Unique Identifier : AIDSLINE MED/99322867; Despotes J; Berger B
Hemophilia: a story of success--disaster and the perseverance of the human spirit, Part 2.: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):88-92. Unique Identifier : AIDSLINE MED/99322868; Dubin CS
Depressive symptoms and HIV disease.: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):93-4. Unique Identifier : AIDSLINE MED/99322869; Moneyham L; University of South Carolina, College of Nursing, USA.
HCFA mandates Medicaid reimbursement for AIDS wasting drug [news]: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):95. Unique Identifier : AIDSLINE MED/99322870
Patient's adherence to antiretroviral medications to control HIV disease [letter]: J Assoc Nurses AIDS Care. 1999 Jul-Aug;10(4):96-7. Unique Identifier : AIDSLINE MED/99322871; Raper J
[Client anxiety from awareness of personal HIV risk and relation to taking HIV test at public health centers in Japan]: Nippon Koshu Eisei Zasshi. 1999 Apr;46(4):275-88. Unique Identifier : AIDSLINE MED/99420719; Takahashi S; Yamazaki Y; Kawata C; Department of Health Sociology, Graduate School of Medicine,; University of Tokyo.; Clients taking HIV antibody tests at public health centers (PHCs) in Japan were surveyed in autumn of 1995 centered on 17 PHCs selected by a snow-ball sampling method in domestic PHCs. The anonymous self-administered questionnaires were given out by PHC s medical doctors or public h
[The establishment of screening system for HIV and Chlamydia trachomatis antibodies among pregnant women in Nagasaki]: Nippon Koshu Eisei Zasshi. 1999 Apr;46(4):304-10. Unique Identifier : AIDSLINE MED/99420722; Yamamoto T; Kusano Y; Moji K; Moriuchi R; Kurokawa K; Kubota K; Mizota T; Katamine S
[The survey of HIV infection among clients of foreign female prostitutes in Tokyo Metropolitan]: Nippon Koshu Eisei Zasshi. 1999 Aug;46(8):638-43. Unique Identifier : AIDSLINE MED/99426039; Ichikawa S; Ohya H; Kihara M; Sankary TM; Kihara M; Imai M; Kondo M; Kanagawa Prefectural College of Nursing and Medical Technology.; OBJECTIVES: It is important to elucidate the risks to foreign female prostitutes of HIV infection from their clients. We determined the prevalence of HIV among clients of foreign female prostitutes using anonymous testing of condom semen samples. METHODS: A total of 250 client condom semen samples were collected with
The role of the membrane-spanning domain sequence in glycoprotein-mediated membrane fusion.: Mol Biol Cell. 1999 Sep;10(9):2803-15. Unique Identifier : AIDSLINE MED/99402792; Taylor GM; Sanders DA; Department of Biological Sciences, Purdue University, West; Lafayette, Indiana 47907-1392, USA.; The role of glycoprotein membrane-spanning domains in the process of membrane fusion is poorly understood. It has been demonstrated that replacing all or part of the membrane-spanning domain of a viral fusion protein with sequences that encode signals for glycosylphosphatidylinositol linkage attachment abrogates membr
Transfusion-associated graft-versus-host disease: an in situ hybridization analysis of the infiltrating donor-derived cells in the cutaneous lesion.: Dermatology. 1999;199(1):20-4. Unique Identifier : AIDSLINE MED/99379925; Tanei R; Ohta Y; Ishihara S; Katsuoka K; Yokono H; Motoori T; Department of Dermatology, School of Medicine, Kitasato; University, Kanagawa, Japan.; BACKGROUND: Acute graft-versus-host disease (GVHD) can occur after a blood transfusion. OBJECTIVE: In order to elucidate the pathomechanisms responsible for transfusion-associated GVHD, infiltrating donor-derived cells in a cutaneous lesion were analyzed. METHODS: A skin sample obtained from a 69-year-old woman who de
Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells.: Dermatology. 1999;199(1):25-30. Unique Identifier : AIDSLINE MED/99379926; Yawalkar N; Reimers A; Hari Y; Hunziker T; Gerber H; Muller U; Pichler W; Institute of Immunology and Allergology, Inselspital Bern,; Switzerland.; BACKGROUND: Previous reports indicate that various drugs may induce linear IgA bullous dermatosis (LABD). The role of T cells and T-cell-derived cytokines in the pathomechanism of such skin lesions, however, has remained unclear. OBJECTIVE: To describe a case of LABD induced by ceftriaxone and metronidazole in an 80-y
Relationship between the clinical efficacy of pentoxifylline treatment and elevation of serum T helper type 2 cytokine levels in patients with human T-lymphotropic virus type I-associated myelopathy.: Intern Med. 1999 Sep;38(9):717-21. Unique Identifier : AIDSLINE MED/99408179; Fujimoto T; Nakamura T; Furuya T; Nakane S; Shirabe S; Kambara C; Hamasaki S; Yoshimura T; Eguchi K; First Department of Internal Medicine, Nagasaki University.; OBJECT: Previously, we reported the efficacy of pentoxifylline (PTX) treatment in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). Here, we clarify the relationship between the clinical efficacy of PTX treatment and elevation of T helper type 2 (Th2) cytokine levels in HAM patients. PATIENTS AND
Correlation between increased cortisol:DHEA ratio and malnutrition in HIV-positive men.: Nutrition. 1999 Jul-Aug;15(7-8):534-9. Unique Identifier : AIDSLINE MED/99350982; Christeff N; Melchior JC; Mammes O; Gherbi N; Dalle MT; Nunez EA; Laboratoire de Biochimie Endocrinienne et Biochimie B, Faculte; de Medecine et Hopital X. Bichat, Paris, France.; Malnutrition in HIV-infected patients is characterized by a loss of both fat-free mass (FFM) and fat mass (FM). Glucocorticoids and androgens change during the course of the infection and may play a key role in the protein balance. The serum concentrations of cortisol, adrenal (DHEA and DHEA sulfate) and gonadal andro
Therapy for HIV: restoring the balance? [editorial]: Nutrition. 1999 Jul-Aug;15(7-8):590-1. Unique Identifier : AIDSLINE MED/99350992; Macallan DC
Outcome measures for nutritional research in HIV/AIDS.: Nutrition. 1999 Jul-Aug;15(7-8):638-40. Unique Identifier : AIDSLINE MED/99351002; Keithley JK; Swanson B; Rush University College of Nursing, Chicago, IL 60612, USA.; jkeithley@rushu.rush.edu
[White-noise field campimetry in HIV+ patients]: Ophthalmologe. 1999 Jul;96(7):437-42. Unique Identifier : AIDSLINE MED/99409165; Hettesheimer H; Erb C; Schiefer U; Zrenner E; Abteilung fur Pathophysiologie des Sehens und; Neuroophthalmologie, Universitats-Augenklinik Tubingen.; PURPOSE: The first morphological changes in eyes with HIV infection are microvascular disease of the retina with cotton-wool spots and microaneurysms. The study was performed to find out if evidence of disturbances of ocular microcirculation can be established by non-invasive methods. PATIENTS AND METHODS: Twenty-seve
Regulation of NF-kappaB by the HTLV-1 Tax protein.: Gene Expr. 1999;7(4-6):233-45. Unique Identifier : AIDSLINE MED/99366836; Li XH; Gaynor RB; Department of Medicine, Harold Simmons Cancer Center, University; of Texas Southwestern Medical Center, Dallas 75235-8594, USA.; The Tax protein encoded by the human T-cell leukemia virus type 1 (HTLV-1) activates viral gene expression via the ATF/CREB pathway. Tax also induces a variety of cellular genes through activation of the transcription factor NF-kappaB. The ability of Tax to activate the NF-kappaB pathway plays an essential role in HTL
HIV infection of placental macrophages: effect on the secretion of HIV stimulatory cytokines.: Cell Mol Biol (Noisy-le-grand). 1999 Jun;45(4):423-31. Unique Identifier : AIDSLINE MED/99359136; Plaud-Valentin M; Delgado R; Garcia V; Zorrilla C; Gandia J; Melendez-Guerrero LM; Department of Microbiology and Medical Zoology, University of; Puerto Rico, School of Medicine, 00936-5067, USA.; Vertical transmission of HIV-1 can occur at three different stages: during gestation, delivery and breast feeding. To determine the role of cytokines in vertical transmission of HIV during gestation, we studied the secretion of IL-1beta, TNF-alpha and IL-6 from in vitro infected and Mock-infected placental macrophages
Empirical power for distribution-free tests of incomplete longitudinal data with applications to AIDS clinical trials.: J Biopharm Stat. 1999 Aug;9(3):401-16. Unique Identifier : AIDSLINE MED/99400007; Kuhn AM; DeMasi RA; Becton Dickinson Microbiology Systems, Sparks, Maryland; 21152-0999, USA.; The design of AIDS clinical trials is of growing importance. These studies tend to be longitudinal and typically involve missing data. HIV-1 RNA is a common endpoint for these studies and is inherently non-normal, although viral load can be measured only within certain bounds, resulting in censored data. We compared s
Functional screening of an asthma QTL in YAC transgenic mice.: Nat Genet. 1999 Oct;23(2):241-4. Unique Identifier : AIDSLINE MED/99438404; Symula DJ; Frazer KA; Ueda Y; Denefle P; Stevens ME; Wang ZE; Locksley R; Rubin EM; Genome Science Department, Lawrence Berkeley National Laboratory,; Berkeley, California 94720, USA.; Many quantitative trait loci (QTLs) contributing to genetically complex conditions have been discovered, but few causative genes have been identified. This is mainly due to the large size of QTLs and the subtle connection between genotype and quantitative phenotype associated with these conditions. Transgenic mice hav
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Aug 27;9(35):317-8. Unique Identifier : AIDSLINE MED/99436688
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Sep 24;9(39):353-4. Unique Identifier : AIDSLINE MED/99440259
[Women, the forgotten ones in AIDS research]: Infirm Que. 1999 Jan-Feb;6(3):41-4. Unique Identifier : AIDSLINE MED/99329576; Gendron C; Carrier M; Faculte des sciences infirmieres de l'Universite Laval.
Changing conditions and treatments in a dynamic cohort of ambulatory HIV patients: the HIV outpatient study (HOPS).: Ann Epidemiol. 1999 Aug;9(6):349-57. Unique Identifier : AIDSLINE MED/99402519; Moorman AC; Holmberg SD; Marlowe SI; Von Bargen JC; Yangco BG; Palella FJ; Ward DJ; Loveless MO; Fuhrer J; Joseph P; Alexander WA; Aschman DJ; Centers for Disease Control and Prevention, Atlanta, GA 30033,; USA.; PURPOSE: Most HIV-infected persons are now treated as ambulatory patients. Obtaining continually updated data about these patients changing conditions, therapies, and reimbursement is essential to health care provision and planning. The systematic tracking of patient medical and laboratory information in an ongoing c
IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses.: Br J Pharmacol. 1999 Jul;127(6):1295-304. Unique Identifier : AIDSLINE MED/99396467; Hasko G; Szabo C; Inotek Corp., 100 Cummings Center, Beverly, Massachusetts 01915,; USA. ghasko@inotekcorp.com; Interleukin-12 (IL-12) is a pivotal cytokine in driving the immune system towards a T helper (Th)1 type response and preventing a Th2 type immune profile. Therefore, IL-12 is indispensable in the defense against certain, mainly intracellular pathogens, but overproduction of this cytokine is crucially involved in the e
Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response.: Cell Transplant. 1999 Jul-Aug;8(4):365-73. Unique Identifier : AIDSLINE MED/99405821; Simeonovic CJ; Townsend MJ; Karupiah G; Wilson JD; Zarb JC; Mann DA; Young IG; Division of Molecular Medicine, The John Curtin School of Medical; Research, The Australian National University, Canberra, ACT.; Charmaine.Simeonovic@anu.edu.au; The rejection mechanisms for fetal proislet allografts and pig proislet xenografts in mice are characterized by different intragraft cytokine mRNA profiles and cellular responses. Allograft rejection is predominantly CD8 T-cell-dependent and is associated with a Th1-type cytokine pattern (i.e., IFN-gamma,
On the locus of morphological effects in spoken-word recognition: before or after lexical identification?: Brain Lang. 1999 Jun 1-15;68(1-2):46-53. Unique Identifier : AIDSLINE MED/99365057; Greber C; Frauenfelder UH; Laboratoire de Psycholinguistique Experimentale, Universite de; Geneve, Geneva, Switzerland. greber@vonneumann.cog.jhu.edu; The temporal locus of morphological decomposition in spoken-word recognition was explored in three experiments in which French participants detected the initial CV (LA) or CVC (LAV) in matched monomorphemic pseudosuffixed (lavande) and polymorphemic-suffixed (lavage) carrier words. The proportion of foil trials was in
Feline immunodeficiency virus envelope protein (FIVgp120) causes electrophysiological alterations in rats.: Brain Res. 1999 Jul 31;836(1-2):203-9. Unique Identifier : AIDSLINE MED/99346016; Prospero-Garcia O; Huitron-Resendiz S; Casalman SC; Sanchez-Alavez M; Diaz-Ruiz O; Navarro L; Lerner DL; Phillips TR; Elder JH; Henriksen SJ; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA. opg@servidor.unam.mx; Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco
Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CN