Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase (review). NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase (review).

Viral Immunol. 1998;11(4):167-81. Unique Identifier : AIDSLINE MED/99203068
Menendez-Arias L; Mas A; Domingo E; Centro de Biologia Molecular "Severo Ochoa", CSIC-Universidad; Autonoma de Madrid, Cantoblanco, Spain.

Abstract: Cytotoxic T lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) infection. CTL responses have been demonstrated for most of the HIV gene products, predominantly gag, pol, and env-encoded proteins, and also for the regulatory proteins Nef, Tat, Vif, or Rev. The HIV-1 reverse transcriptase (RT), which derives from expression of the pol gene, is an important target of cellular immune responses in infected individuals. More than 40 different peptides containing RT-specific CTL epitopes have been identified. The most conserved and frequently detected are located in the 'fingers' and 'palm' subdomains of the enzyme, but other epitopes have been found in the 'thumb' and 'connection' subdomains as well as in the RNase H domain. Studies on the sequence variability and functional role of amino acids forming CTL epitopes are relevant for addressing important questions relative to viral escape from immmune control and the future design of anti-AIDS vaccines.
Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Amino Acid Sequence Animal AIDS Vaccines Drug Design Epitopes, T-Lymphocyte/IMMUNOLOGY Human HIV Infections/*IMMUNOLOGY HIV-1 Reverse Transcriptase/GENETICS/*IMMUNOLOGY Molecular Sequence Data Mutation Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/*IMMUNOLOGY Viral Proteins/IMMUNOLOGYKWDjournalarticlereviewreview,tutorialaminoacidsequenceanimalaidsvaccinesdrugdesignepitopes,t-lymphocyte/immunologyhumanhivinfections/KWDimmunologyhiv-1reversetranscriptase/genetics/KWDimmunologymolecularsequencedatamutationsupport,non-uKWDsKWDgov'tt-lymphocytes,cytotoxic/KWDimmunologyviralproteins/immunology
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A9981023

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