The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration.

AIDS. 1999 Mar 11;13(4):487-94. Unique Identifier : AIDSLINE MED/99211234
Hoffman IF; Jere CS; Taylor TE; Munthali P; Dyer JR; Wirima JJ; Rogerson SJ; Kumwenda N; Eron JJ; Fiscus SA; Chakraborty H; Taha TE; Cohen MS; Molyneux ME; University of North Carolina, Division of Infectious Diseases,; Chapel Hill, USA. hoffmani@med.unc.edu

Abstract: OBJECTIVES: This study was undertaken to determine the relative effect of malaria infection on HIV concentration in blood plasma, and prospectively to monitor viral concentrations after antimalarial therapy. DESIGN: A prospective, double cohort study was designed to compare the blood HIV-1 RNA concentrations of HIV-positive individuals with and without acute malaria illness. Subjects were followed for 4 weeks after successful malaria therapy, or for 4 weeks from enrollment (controls). METHODS: Malawian adults with symptomatic Plasmodium falciparum parasitemia (malaria group) and asymptomatic, aparasitemic blood donors (control group) were tested for HIV-1 antibodies to identify appropriate study groups. The malaria group received antimalarial chemotherapy only and were followed with sequential blood films. In both groups, blood plasma HIV-1 RNA viral concentrations were determined at enrollment and again at 1, 2 and 4 weeks. RESULTS: Forty-seven malaria patients and 42 blood donors were enrolled. At enrollment blood plasma HIV-1 RNA concentrations were approximately sevenfold higher in patients with malaria than in blood donors (medians 15.1 x 10(4) and 2.24 x 10(4) copies/ml, respectively, P = 0.0001). No significant changes in median HIV-1 concentrations occurred in the 21 blood donors followed to week 4 (P = 0.68). In the 27 subjects successfully treated for malaria who were followed to week 4, a reduction in plasma HIV-1 RNA was observed from a median of 19.1 x 10(4) RNA copies/ml at enrollment, to 12.0 x 10(4) copies/ml at week 4, (P = 0.02). Plasma HIV-1 concentrations remained higher in malaria patients than controls (median 12.0 x 10(4) compared with 4.17 x 10(4) copies/ml, P = 0.086). CONCLUSIONS: HIV-1 blood viral burden is higher in patients with P. falciparum malaria than in controls and this viral burden can, in some patients, be partly reduced with antimalarial therapy.
Keywords: JOURNAL ARTICLE Adult Animal AIDS-Related Opportunistic Infections/DRUG THERAPY/*VIROLOGY Female Human *HIV-1/GENETICS Malaria, Falciparum/DRUG THERAPY/*VIROLOGY Male Prospective Studies RNA, Viral/BLOOD Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Viral LoadKWDjournalarticleadultanimalaids-relatedopportunisticinfections/drugtherapy/KWDvirologyfemalehumanKWDhiv-1/geneticsmalaria,falciparum/drugtherapy/KWDvirologymaleprospectivestudiesrna,viral/bloodsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
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A9980986

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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