Cryptococcosis in children with AIDS.

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Cryptococcosis in children with AIDS.

Clin Infect Dis. 1999 Feb;28(2):309-13. Unique Identifier : AIDSLINE MED/99162012
Abadi J; Nachman S; Kressel AB; Pirofski L; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.

Abstract: We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/microL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of approximately 1% was estimated.

Keywords: JOURNAL ARTICLE Adult Antifungal Agents/THERAPEUTIC USE AIDS-Related Opportunistic Infections/DRUG THERAPY/IMMUNOLOGY/ *PHYSIOPATHOLOGY Child Child, Preschool Cryptococcosis/DRUG THERAPY/IMMUNOLOGY/*PHYSIOPATHOLOGY Human Infant Retrospective Studies Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
990830
A9980946

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