Human immunodeficiency virus-associated fever of unknown origin: a study of 70 patients in the United States and review. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Human immunodeficiency virus-associated fever of unknown origin: a study of 70 patients in the United States and review.

Clin Infect Dis. 1999 Feb;28(2):341-5. Unique Identifier : AIDSLINE MED/99162016
Armstrong WS; Katz JT; Kazanjian PH; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0378, USA.

Abstract: To characterize the clinical features of human immunodeficiency virus (HIV)-associated fever of unknown origin (FUO) in the United States, we performed a retrospective analysis of cases that fulfilled specific criteria (published by Durack and Street in 1991) at two medical centers in the United States between 1992 and 1997. Seventy cases met criteria for HIV-associated FUO; the mean CD4 cell count was 58/mm3, and the mean duration of fever was 42 days. A cause of FUO was found in 56 of the 70 cases; 43 were of a single etiology, and in 13 cases multiple conditions were established. The most common diagnoses were disseminated Mycobacterium avium infection (DMAC; 31%), Pneumocystis carinii pneumonia (13%), cytomegalovirus infection (11%), disseminated histoplasmosis (7%), and lymphoma (7%). In this United States series, FUO occurs most often in the late stage of HIV infection, individual cases often have multiple etiologies, and DMAC is the most common diagnosis.
Keywords: JOURNAL ARTICLE REVIEW REVIEW OF REPORTED CASES Adult AIDS-Related Opportunistic Infections/*ETIOLOGY Female Fever of Unknown Origin/*ETIOLOGY Human Male Middle Age Retrospective Studies United StatesKWDjournalarticlereviewreviewofreportedcasesadultaids-relatedopportunisticinfections/KWDetiologyfemalefeverofunknownorigin/KWDetiologyhumanmalemiddleageretrospectivestudiesunitedstates
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