Iritis associated with intravenous cidofovir. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Iritis associated with intravenous cidofovir.

Ann Pharmacother. 1999 Feb;33(2):167-71. Unique Identifier : AIDSLINE MED/99181902
Tseng AL; Mortimer CB; Salit IE; The Toronto Hospital, Faculty of Pharmacy, University of Toronto,; Ontario, Canada. atseng@torhosp.toronto.on.ca

Abstract: OBJECTIVE: To report two patients with AIDS and cytomegalovirus retinitis who developed iritis after receiving intravenous cidofovir. Both experienced recurrent symptoms upon rechallenge. CASE SUMMARIES: Two HIV-positive patients with cytomegalovirus retinitis infections previously controlled with intravenous ganciclovir or foscarnet were treated with intravenous cidofovir. Symptoms of iritis developed after the second or third dose of cidofovir. One patient experienced symptoms unilaterally, while the other patient had bilateral symptoms. In both patients, the iritis resolved with topical ophthalmic therapy, but recurred following subsequent infusions of cidofovir. Therapy with cidofovir was discontinued, and no further recurrences of iritis were noted. One patient had post-inflammatory fixed dilated pupils. CONCLUSIONS: Iritis can uncommonly occur in patients receiving intravenous cidofovir and oral probenecid. With prompt drug discontinuation and administration of topical corticosteroids and/or mydriatic agents, symptoms are usually reversible.
Keywords: JOURNAL ARTICLE Adult Antiviral Agents/*ADVERSE EFFECTS AIDS-Related Opportunistic Infections/*DRUG THERAPY Case Report Cytomegalovirus Retinitis/*DRUG THERAPY Cytosine/*ANALOGS & DERIVATIVES/ADVERSE EFFECTS Human Infusions, Intravenous Iritis/*CHEMICALLY INDUCED Male Organophosphorus Compounds/*ADVERSE EFFECTSKWDjournalarticleadultantiviralagents/KWDadverseeffectsaids-relatedopportunisticinfections/KWDdrugtherapycasereportcytomegalovirusretinitis/KWDdrugtherapycytosine/KWDanalogs&derivatives/adverseeffectshumaninfusions,intravenousiritis/KWDchemicallyinducedmaleorganophosphoruscompounds/KWDadverseeffects
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