Lymphoepithelial duct lesions in Sjogren-type sialadenitis. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Lymphoepithelial duct lesions in Sjogren-type sialadenitis.

Virchows Arch. 1999 Apr;434(4):315-23. Unique Identifier : AIDSLINE MED/99266973
Ihrler S; Zietz C; Sendelhofert A; Riederer A; Lohrs U; Institute of Pathology, Ludwig Maximilians University of Munich,; Germany.

Abstract: It is not clear, whether the so-called basal cells of the salivary striated ducts are an independent cell-type distinct from myoepithelial cells, making characterization of the cell proliferation typical of the duct lesions in Sjogren-type sialadenitis/benign lymphoepithelial lesion (BLEL) difficult. An immunohistochemical investigation including different cytokeratin subtypes, alpha-actin, Ki-67 and Bcl-2 was directed at the epithelial cytoskeleton in normal parotid parenchyma (n=8), BLEL (n=12), HIV-associated lymphoepithelial cysts (n=8) and palatine tonsils (n=8). There are profound morphological and functional differences between basal and myoepithelial cells in the normal salivary duct. Development of duct lesions in BLEL arises from basal cell hyperplasia of striated ducts with aberrant differentiation into a multi-layered and reticulated epithelium, characterized by profound alteration of the cytokeratin pattern. This functionally inferior, metaplastic epithelium is similar to the lymphoepithelial crypt epithelium of palatine tonsils. The often postulated participation of myoepithelial cells in duct lesions of Sjogren disease/BLEL cannot be supported. We regard the designations lymphoepithelial lesion and lymphoepithelial metaplasia as the most appropriate.
Keywords: JOURNAL ARTICLE Adolescence Adult Aged Biological Markers/ANALYSIS Cytoskeleton/METABOLISM/PATHOLOGY Epithelial Cells/METABOLISM/PATHOLOGY Female Human Hyperplasia HIV Infections/COMPLICATIONS/PATHOLOGY Immunoenzyme Techniques Keratin/ANALYSIS Lymphocele/COMPLICATIONS/PATHOLOGY Male Middle Age Parotid Diseases/METABOLISM/*PATHOLOGY Parotid Gland/METABOLISM/PATHOLOGY Salivary Ducts/METABOLISM/*PATHOLOGY Sialadenitis/METABOLISM/*PATHOLOGY Sjogren's Syndrome/METABOLISM/*PATHOLOGY Tonsil/METABOLISM/PATHOLOGY
990830
A9980927

Copyright © 1999 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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