Low incidence of human herpesvirus 8 in stem cell collections from myeloma patients. NLM AIDSLINE Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

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Low incidence of human herpesvirus 8 in stem cell collections from myeloma patients.

Bone Marrow Transplant. 1999 Apr;23(8):759-61. Unique Identifier : AIDSLINE MED/99246167
Cull GM; Carter GI; Timms JM; Thomson BJ; Russell NH; Haynes AP; Department of Haematology, University of Nottingham at Nottingham; City Hospital, UK.

Abstract: Human herpesvirus 8 is a gammaherpesvirus which may be implicated in the pathogenesis of multiple myeloma. Viral DNA sequences have been found in the bone marrow, peripheral blood and leukapheresis products of myeloma patients. These findings have significant implications for the use of leukapheresed cells in the transplantation and immunotherapy of myeloma. The studies suggest the cell which harbours the virus may be dendritic in origin. We have previously reported that dendritic cells cultured for use in the clinical setting do not harbour HHV-8. In this study, we examined the leukapheresis products of a larger cohort of myeloma patients for the presence of HHV-8 using a highly sensitive PCR technique. A strong association between HHV-8 and myeloma was not confirmed, with only 4% of the patient samples positive for viral sequences. While further study is needed, the current use of apheresis cells and their cultured progeny in the treatment of myeloma should not be compromised.
Keywords: JOURNAL ARTICLE Adult Aged Female Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells/*VIROLOGY Herpesvirus, Kaposi Sarcoma-Associated/*ISOLATION & PURIF Human Leukapheresis Male Middle Age Multiple Myeloma/*VIROLOGY Polymerase Chain Reaction Transplantation, AutologousKWDjournalarticleadultagedfemalehematopoieticstemcelltransplantationhematopoieticstemcells/KWDvirologyherpesvirus,kaposisarcoma-associated/KWDisolation&purifhumanleukapheresismalemiddleagemultiplemyeloma/KWDvirologypolymerasechainreactiontransplantation,autologous
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