Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors.

Clin Immunol Immunopathol. 1997 Dec;85(3):320-3. Unique Identifier : AIDSLINE MED/98063352
Rusconi S; Berlusconi A; Papagno L; Colombo MC; De Maddalena C; Riva A; Bagnarelli P; Balotta C; Galli M; Istituto di Malattie Infettive, Universita di Milano, Ospedale Luigi; Sacco, Italy. rusconi@imiucca.csi.unimi.it

Abstract: With the aim of evaluating the specific pattern of in vitro antibody production (IVAP) in human immunodeficiency virus type 1 HIV-1)-infected long-term non-progressors (LTNPs), we tested 20 subjects who had remained asymptomatic for more than 8 years with a CD4+ cell count higher than 500/microliter and 59 patients at different stages of HIV-1 infection as controls. In cell cultures, IVAP was detected in 14 out of 20 LTNPs (70%), in 5 out of 6 recent seroconverters (83%), and in all the other control patients. Anti-p24 antibody production was significantly lower in LTNPs than in asymptomatic patients with a more recent infection. Recent seroconverters and patients with AIDS did not produce anti-p24 antibodies (P = 0.02). Anti-gp160 antibodies were produced by peripheral blood mononuclear cells from LTNPs in 12/20 cases. CD4+ cell count was significantly higher in IVAP-negative than in IVAP-positive LTNPs (P = 0.013), while the viral load was not significantly different. Specific anti-HIV-1 antibody production did not seem to be a correlate of long-term nonprogression.
Keywords: *Acquired Immunodeficiency Syndrome/IMMUNOLOGY *CD4 Lymphocyte Count *HIV Antibodies/BLOOD *HIV-1/IMMUNOLOGYKWDacquiredimmunodeficiencysyndrome/immunologyKWDcd4lymphocytecountKWDhivantibodies/bloodKWDhiv-1/immunology
980330
M9831198

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