Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus.

Endocrinology. 1997 Dec;138(12):5505-10. Unique Identifier : AIDSLINE MED/98049405
Nguyen TM; Pavlovitch J; Papiernik M; Guillozo H; Walrant-Debray O; Pontoux C; Garabedian M; CNRS, URA 583, Universite Paris V, Hopital Saint-Vincent de Paul,; France.

Abstract: This study examines the influence of chronic retroviral infection of mice with a LPBM5 virus mixture on the paracrine system involving immune cells and 1,25-(OH)2D3 in the spleen. Plasma ionized calcium, 25-(OH)D and 1,25-(OH)2D of infected mice were unchanged. In contrast, the specific binding of 1,25-(OH)2D3 to spleen cytosol and the number of monocyte/macrophages expressing 1,25-(OH)2D3 receptors (VDR) were markedly increased. The retroviral infection also influenced the local production of 1,25-(OH)2D3 in the spleen. It did not alter this production in monocyte/macrophages but increased that in isolated T cells. Isolated B cells in control mice did not produce 1,25-(OH)2D3, but they increased the ability of isolated T cells to produce this metabolite during coculture incubations. Infection altered this cell interaction as 1,25-(OH)2D3 production in infected T cells decreased when these cells were cocultured with infected B cells. Thus, chronic retroviral infection alters both the local vitamin D metabolism and VDR expression by immune cells in mice. These findings suggest close local interactions between 1,25-(OH)2D3 and immune system activation during retroviral infection.
Keywords: *Calcitriol/METABOLISM *Murine Acquired Immunodeficiency Syndrome/METABOLISM *Receptors, Cell Surface/METABOLISM *Spleen/METABOLISMKWDcalcitriol/metabolismKWDmurineacquiredimmunodeficiencysyndrome/metabolismKWDreceptors,cellsurface/metabolismKWDspleen/metabolism
980330
M9831196

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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