A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.

J Virol. 1997 Dec;71(12):9764-9. Unique Identifier : AIDSLINE MED/98037693
Desrosiers RC; Sasseville VG; Czajak SC; Zhang X; Mansfield KG; Kaur A; Johnson RP; Lackner AA; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.

Abstract: A herpesvirus that is related to but distinct from the Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.
Keywords: *Herpesviridae Infections/VETERINARY *Herpesvirus, Kaposi Sarcoma-Associated *Macaca mulatta/VIROLOGY *Rhadinovirus/ISOLATION & PURIF *Sarcoma, Kaposi/VIROLOGY *Tumor Virus Infections/VETERINARYKWDherpesviridaeinfections/veterinaryKWDherpesvirus,kaposisarcoma-associatedKWDmacacamulatta/virologyKWDrhadinovirus/isolation&purifKWDsarcoma,kaposi/virologyKWDtumorvirusinfections/veterinary
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M9831167

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